Steven A. Leadon
American academic
Steven A. Leadon's AcademicInfluence.com Rankings

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Computer Science
Steven A. Leadon's Degrees
- Masters Computer Science Stanford University
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Why Is Steven A. Leadon Influential?
(Suggest an Edit or Addition)According to Wikipedia, Steven A. Leadon is a former professor of radiation oncology at the University of North Carolina. In 2003, a university found that Leadon had fabricated and falsified data in his research on DNA repair. In 2006, the United States Office of Research Integrity came to the same conclusion, saying that "Leadon engaged in scientific misconduct by falsifying DNA samples and constructing falsified figures for experiments done in his laboratory to support claimed findings of defects in a DNA repair process that involved rapid repair of DNA damage in the transcribed strand of active genes, included in four grant applications and in eight publications and one published manuscript".
Steven A. Leadon's Published Works
Published Works
- BRCA1 required for transcription-coupled repair of oxidative DNA damage. (1998) (512)
- Defective Transcription-Coupled Repair of Oxidative Base Damage in Cockayne Syndrome Patients from XP Group G (1997) (310)
- RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome (2000) (247)
- Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. (1993) (217)
- Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage. (1998) (208)
- Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies. (1989) (190)
- Transcription-Coupled Repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome (2005) (187)
- Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor. (1989) (171)
- A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function. (1997) (144)
- Strand-selective repair of DNA damage in the yeast GAL7 gene requires RNA polymerase II. (1992) (128)
- Monoclonal antibody to DNA containing thymine glycol. (1983) (120)
- The Ataxia telangiectasia Gene Product Is Required for Oxidative Stress-induced G1 and G2Checkpoint Function in Human Fibroblasts* (2001) (116)
- Preferential repair of DNA damage on the transcribed strand of the human metallothionein genes requires RNA polymerase II. (1991) (93)
- A rapid and mild procedure for the isolation of DNA from mammalian cells. (1982) (91)
- Symposium overview: genetic polymorphisms in DNA repair and cancer risk. (2002) (89)
- Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing. (1988) (74)
- Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice (1999) (72)
- Differential repair of DNA damage in the human metallothionein gene family (1988) (71)
- Excision repair of aflatoxin B1-DNA adducts in human fibroblasts. (1981) (67)
- Relationship of resistance to oxygen free radicals to CuZn‐superoxide dismutase activity in transgenic, transfected, and trisomic cells (1992) (50)
- Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae. (1998) (47)
- Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair. (1997) (42)
- Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light (1999) (41)
- Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities. (1999) (40)
- Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice (2006) (31)
- The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols. (1995) (29)
- Differential repair of DNA damage in specific nucleotide sequences in monkey cells. (1986) (27)
- Restricted repair of aflatoxin B1 Induced damage In α DNA of monkey cells (1983) (27)
- Enhanced transforming activity of pSV2 plasmids in human cells depends upon the type of damage introduced into the plasmid. (1988) (26)
- Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody. (1986) (22)
- 141 Gemcitabine: In vitro and in vivo evidence of its radiation sensitizing activity and studies using fluorine-19 magnetic resonance spectroscopy to determine an optimal gemcitabine dosing schedule - pre-clinical observations relevant to gemcitabine clinical trials (1997) (21)
- Measuring DNA damage using capillary electrophoresis with laser-induced fluorescence detection. (2000) (20)
- Comparative removal of pyrimidine dimers from human epidermal keratinocytes in vivo and in vitro. (1988) (20)
- Cell-cycle-dependent repair of damage in alpha and bulk DNA of monkey cells. (1986) (18)
- Production and repair of DNA damage in mammalian cells. (1990) (18)
- Ultraviolet irradiation of monkey cells enhances the repair of DNA adducts in alpha DNA. (1984) (17)
- Coal tar residues produce both DNA adducts and oxidative DNA damage in human mammary epithelial cells. (1995) (16)
- Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2. (2000) (16)
- Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair. (1997) (16)
- A novel DNA repair response is induced in human cells exposed to ionizing radiation at the G1/S-phase border. (1996) (15)
- alpha DNA in African green monkey cells is organized into extremely long tandem arrays. (1986) (12)
- Global genome removal of thymine glycol in Escherichia coli requires endonuclease III but the persistence of processed repair intermediates rather than thymine glycol correlates with cellular sensitivity to high doses of hydrogen peroxide. (2002) (11)
- Factors influencing the removal of thymine glycol from DNA in γ-irradiated human cells (2001) (10)
- Relationship between the induction of mitotic gene conversion and the formation of thymine glycols in yeast S. cerevisiae treated with hydrogen peroxide. (1988) (10)
- Defective Repair of Ionizing Radiation Damage in Cockayne's Syndrome and Xeroderma Pigmentosum Group G a (1994) (10)
- Induced repair of DNA double-strand breaks at the G1/S-phase border. (1999) (9)
- Restricted repair of aflatoxin B1 induced damage in alpha DNA of monkey cells. (1983) (8)
- Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody. (1987) (7)
- Immunofluorescence detection of radiation-induced DNA base damage. (2002) (7)
- TP53 is not required for the constitutive or induced repair of DNA damage produced by ionizing radiation at the G1/S-phase border. (1999) (7)
- Transcription-coupled repair: a multifunctional signaling pathway. (2000) (7)
- Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells. (2001) (6)
- Enhanced transforming activity of ultraviolet-irradiated pSV2-gpt is due to damage outside the gpt transcription unit. (1987) (6)
- The effect of gamma-irradiated DNA on the activity of DNA polymerase. (1981) (6)
- Measurement of oxidative DNA damage and repair in specific DNA sequences. (2000) (6)
- Benzo[A]pyrene-induced oxidative DNA damage in human mammary epithelial cells: Effects of metabolic intermediates and arachidonic acid cascade inhibitors (1990) (5)
- DNA Polymerase a and Activity in ?-irradiated HeLa S3 Cells (1981) (2)
- Corrigendum to “Retraction” [DNA Repair 2 (2003) 361] (2003) (1)
- Retraction notice to "The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols" [Mutat. Res. 337 (1995) 169-178]. (2006) (1)
- Repair and Expression of Aflatoxin B 1 -Induced DNA Damage (1983) (1)
- P25 18 WP – STRAND SELECTIVE REPAIR OF DNA DAMAGE IN HUMAN GENES REQUIRES RNA POLYMERASE II (1991) (0)
- Defects in Transcription-Coupled Repair of Oxidative Base Damage in Xeroderma Pigmentosum with Cockayne Syndrome (1997) (0)
- 2222 Title of paper: The induction of P-53 independent programmed cell death (apoptosis) with ionizing radiation and 5-fluorouracil (5-FU) in the HT-29 human colon carcinoma cell line (1996) (0)
- Induction of benzo(a)pyrene metabolism in human mammary epithelial cells by manufactured gas residues (1994) (0)
- DNA polymerase alpha and beta activity in gamma-irradiated HeLa S3 cells. (1981) (0)
- Retraction (2003) (0)
- Immunotoxins and Radionuclide Conjugates for Inhibiting Growth of Ovarian and Breast Cancer Cells That Overexpress HER-2 1 (2000) (0)
- Synergistic Interaction between Anti-p 185 HER-2 Ricin A Chain Immunotoxins and Radionuclide Conjugates for Inhibiting Growth of Ovarian and Breast Cancer Cells That Overexpress HER-21 (2000) (0)
- Global asymptotic coherence in discrete dynamical systems (2006) (0)
- The Production and Repair of Aflatoxin B{sub 1}-induced DNA Damage (1990) (0)
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