Stuart Linn
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Chemistry Biology
Stuart Linn's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Stuart Linn's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. (2004) (3219)
- DNA damage and oxygen radical toxicity. (1988) (1994)
- Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. (1988) (1437)
- DNA modification and restriction. (1969) (569)
- Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide* (1997) (556)
- Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide (1987) (378)
- A human RNA polymerase II complex associated with SRB and DNA-repair proteins (1996) (368)
- Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide (1986) (345)
- Sequence-specific DNA Cleavage by Fe2+-mediated Fenton Reactions Has Possible Biological Implications* (1999) (329)
- DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair* (2002) (243)
- DNA N-glycosylases and UV repair (1980) (234)
- Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E. (1993) (217)
- Escherichia coli xth mutants are hypersensitive to hydrogen peroxide (1983) (207)
- Purification and properties of the recBC DNase of Escherichia coli K-12. (1972) (206)
- Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T. (1993) (205)
- Implication of Mammalian Ribosomal Protein S3 in the Processing of DNA Damage (*) (1995) (179)
- Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form. (1962) (175)
- DNA repair synthesis in human fibroblasts requires DNA polymerase delta. (1988) (173)
- Mutations Specific to the Xeroderma Pigmentosum Group E Ddb− Phenotype* (1996) (168)
- Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. (1995) (167)
- An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts. (1976) (152)
- Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. (1988) (148)
- Human Damage-specific DNA-binding Protein p48 (2000) (146)
- Hydroxymethyluracil DNA glycosylase in mammalian cells. (1984) (143)
- Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA. (1994) (142)
- DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells. (1990) (133)
- Oxidative Damage to DNA Constituents by Iron-mediated Fenton Reactions (1996) (131)
- Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA. (1980) (130)
- AN ENDONUCLEASE FROM NEUROSPORA CRASSA SPECIFIC FOR POLYNUCLEOTIDES LACKING AN ORDERED STRUCTURE. I. PURIFICATION AND PROPERTIES OF THE ENZYME. (1965) (128)
- Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells. (1981) (126)
- Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein. (1994) (123)
- 5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide. (1982) (122)
- Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts. (1976) (119)
- Endonuclease from Escherichia coli that acts specifically upon duplex DNA damaged by ultraviolet light, osmium tetroxide, acid, or x-rays. (1977) (118)
- Characterization of a large form of DNA polymerase delta from HeLa cells that is insensitive to proliferating cell nuclear antigen. (1989) (116)
- An endonuclease activity from Escherichia coli absent from certain rec- strains. (1970) (115)
- Endonuclease V of Escherichia coli. (1977) (110)
- HOST SPECIFICITY OF DNA PRODUCED BY Escherichia coli, XI. In vitro MODIFICATION OF PHAGE FD REPLICATIVE FORM (1968) (107)
- The Naturally Occurring Mutants of DDB Are Impaired in Stimulating Nuclear Import of the p125 Subunit and E2F1-Activated Transcription (1999) (107)
- Damaged DNA-binding Protein DDB Stimulates the Excision of Cyclobutane Pyrimidine Dimers in Vitro in Concert with XPA and Replication Protein A* (2001) (103)
- DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen (2004) (101)
- Purification of All Forms of HeLa Cell Mitochondrial DNA and Assessment of Damage to It Caused by Hydrogen Peroxide Treatment of Mitochondria or Cells (*) (1995) (98)
- The mechanisms of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites. (1988) (97)
- Partial purification and characterization of four endodeoxyribonuclease activities from Escherichia coli K-12. (1974) (95)
- The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. I. Purification, subunit structure, and catalytic properties of the modification methylase. (1972) (94)
- AN ENDONUCLEASE FROM NEUROSPORA CRASSA SPECIFIC FOR POLYNUCLEOTIDES LACKING AN ORDERED STRUCTURE. II. STUDIES OF ENZYME SPECIFICITY. (1965) (92)
- Modulation of the action of the recBC enzyme of Escherichia coli K-12 by Ca2+. (1979) (91)
- Identification and Cloning of Two Histone Fold Motif-containing Subunits of HeLa DNA Polymerase ε* (2000) (90)
- The gamma protein specified by bacteriophage gamma. Structure and inhibitory activity for the recBC enzyme of Escherichia coli. (1975) (88)
- Revised nomenclature for eukaryotic DNA polymerases. (1990) (87)
- Nuclear Transport of Human DDB Protein Induced by Ultraviolet Light* (2000) (82)
- Further characterization of a cell-free system for measuring replicative and repair DNA synthesis with cultured human fibroblasts and evidence for the involvement of DNA polymerase alpha in DNA repair. (1979) (80)
- How many pols does it take to replicate nuclear DNA? (1991) (77)
- Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48DDB2 and p53 (2003) (76)
- Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system. (1996) (76)
- Human DNA Polymerase ε Colocalizes with Proliferating Cell Nuclear Antigen and DNA Replication Late, but Not Early, in S Phase* 210 (2002) (75)
- Excision repair and DNA synthesis with a combination of HeLa DNA polymerase beta and DNase V. (1983) (74)
- Reinvestigation of the classification of five cell strains of xeroderma pigmentosum group E with reclassification of three of them. (2000) (73)
- Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA. (1990) (72)
- Biochemical heterogeneity in xeroderma pigmentosum complementation group E. (1992) (70)
- Localization of Fe2+ at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe2+ and H2O2 (2001) (70)
- Selective inhibition of the dnase activity of the recBC enzyme by the DNA binding protein from Escherichia coli. (1976) (69)
- The mechanism of degradation of duplex deoxyribonucleic acid by the recBC enzyme of Escherichia coli K-12. (1974) (69)
- A unified mechanism for the nuclease and unwinding activities of the recBC enzyme of Escherichia coli. (1982) (69)
- DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites. (1979) (67)
- On the recognition and cleavage mechanism of Escherichia coli endodeoxyribonuclease V, a possible DNA repair enzyme. (1982) (67)
- Fe2+, Fe3+, and oxygen react with DNA-derived radicals formed during iron-mediated Fenton reactions. (1996) (66)
- The recBC deoxyribonuclease of Escherichia coli K-12. Substrate specificity and reaction intermediates. (1973) (65)
- A Plant Phytotoxin, Solanapyrone A, Is an Inhibitor of DNA Polymerase β and λ* (2002) (63)
- Further characterization of human fibroblast apurinic/apyrimidinic DNA endonucleases. The definition of two mechanistic classes of enzyme. (1980) (62)
- The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. (1972) (61)
- Purification and Properties of the γ-Protein Specified by Bacteriophage λ: An Inhibitor of the Host RecBC Recombination Enzyme (1973) (60)
- Toxicity, Mutagenesis and Stress Responses Induced in Escherichia Coli by Hydrogen Peroxide (1987) (60)
- Effects of Hydrogen Peroxide upon Nicotinamide Nucleotide Metabolism in Escherichia coli (2003) (59)
- Isolation and characterization of two chondroitin lyases from Bacteroides thetaiotaomicron (1983) (59)
- Electron microscopic studies of the mechanism of action of the restriction endonuclease of Escherichia coli B. (1979) (58)
- The DNA restriction endonuclease of Escherichia coli B. I. Studies of the DNA translocation and the ATPase activities. (1985) (56)
- Human endonuclease specific for apurinic/apyrimidinic sites in DNA. Partial purification and characterization of multiple forms from placenta. (1977) (55)
- Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase. (2002) (55)
- MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. (2000) (54)
- Dehydroaltenusin, a Mammalian DNA Polymerase α Inhibitor* (2000) (53)
- Oxidative Damage to DNA Constituents by Iron-mediated Fenton Reactions (1996) (53)
- The Deoxyribonucleases of Escherichia coli (1982) (50)
- Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km. (1978) (49)
- Purification, cDNA Cloning, and Gene Mapping of the Small Subunit of Human DNA Polymerase ε* (1997) (49)
- Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases. (2002) (48)
- Basal transcriptional regulation of human damage-specific DNA-binding protein genes DDB1 and DDB2 by Sp1, E2F, N-myc and NF1 elements. (2003) (46)
- The DNA restriction endonuclease of Escherichia coli B. II. Further studies of the structure of DNA intermediates and products. (1985) (46)
- Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties. (1987) (45)
- An endonuclease from mitochondria of Neurospora crassa. (1966) (44)
- 13 recBC-like Enzymes: Exonuclease V Deoxyribonucleases (1981) (44)
- Characterization of the action of Escherichia coli DNA polymerase I at incisions produced by repair endodeoxyribonucleases. (1982) (44)
- DNA Repair Synthesis in Human Fibroblasts Requires DNA Polymerase 6 * (43)
- Petasiphenol: A DNA Polymerase λ Inhibitor† (2002) (42)
- Steady-state and time-resolved fluorescence studies indicate an unusual conformation of 2-aminopurine within ATAT and TATA duplex DNA sequences. (2003) (40)
- Purification and properties of a single strand-specific endonuclease from mouse cell mitochondria. (1986) (40)
- A reduced rate of bulky DNA adduct removal is coincident with differentiation of human neuroblastoma cells induced by nerve growth factor (1988) (40)
- Changes in DNA polymerases alpha, beta, and gamma during the replicative life span of cultured human fibroblasts. (1982) (40)
- Isolation of an altered form of DNA polymerase I from Escherichia coli cells induced for recA/lexA functions. (1982) (40)
- 9 Nucleases Involved in DNA Repair (1982) (39)
- A critical review of permeabilized cell systems for studying mammalian DNA repair. (1990) (39)
- A cell-free assay measuring repair DNA synthesis in human fibroblasts. (1978) (38)
- DNA-repair reactions by purified HeLa DNA polymerases and exonucleases. (1988) (38)
- Characterization of a Schizosaccharomyces pombeStrain Deleted for a Sequence Homologue of the Human Damaged DNA Binding 1 (DDB1) Gene* (2002) (37)
- Gap-filling DNA synthesis by HeLa DNA polymerase alpha in an in vitro base excision DNA repair scheme. (1984) (37)
- IN VIVO EXCISION OF PYRIMIDINE DIMERS IS MEDIATED BY A DNA N‐GLYCOSYLASE IN MICROCOCCUS LUTEUS BUT NOT IN HUMAN FIBROBLASTS (1982) (37)
- A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor. (2003) (36)
- Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. (2007) (36)
- Excision repair of pyrimidine dimers from simian virus 40 minichromosomes in vitro. (1984) (36)
- Stimulation of human DNA polymerase ϵ by MDM2 (2003) (35)
- Localization of Fe(2+) at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe(2+) and H2O2. (2001) (35)
- [31] An endonuclease from Neurospora crassa specific for polynucleotides lacking an ordered structure (1967) (35)
- DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells. (1987) (35)
- Characterization of an endonuclease associated with the drug resistance plasmid pKM101 (1977) (34)
- Characterization of DNA polymerase I*, a form of DNA polymerase I found in Escherichia coli expressing SOS functions. (1985) (34)
- Preferential binding and structural distortion by Fe2+ at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences (2005) (34)
- Uncoupling of the recBC ATPase from DNase by DNA crosslinked with psoralen. (1972) (34)
- The deoxyribonucleic acid modification and restriction enzymes of Escherichia coli B. II. Purification, subunit structure, and catalytic properties of the restriction endonuclease. (1972) (33)
- A human RNA polymerase II complex associated with SRB and DNA-repair proteins (1996) (32)
- Host range, immunity and antigenic properties of lambdoid coliphage HK97. (1980) (32)
- Human uracil DNA N-glycosidase: studies in normal and repair defective cultured fibroblasts (1978) (32)
- Studies of the murine DDB1 and DDB2 genes. (2000) (31)
- DNA polymerases alpha and delta are immunologically and structurally distinct. (1989) (30)
- Host-Controlled Modification and Restriction of Bacteriophage T7 by Escherichia coli B (1973) (30)
- Recognition site of Escherichia coli B restriction enzyme on phi XsB1 and simian virus 40 DNAs: an interrupted sequence. (1978) (29)
- Analysis of the mammalian recombination protein complex RC-1. (1996) (28)
- Purification and characterization of UV endonucleases I and II from murine plasmacytoma cells. (1989) (27)
- Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation. (2000) (26)
- DNA repair in cultured mouse cells of increasing population doubling level. (1984) (25)
- Studies of DNA polymerases alpha and beta from cultured human cells in various replicative states (1986) (25)
- Fidelity of fractionated deoxyribonucleic acid polymerases from human placenta. (1980) (24)
- Stimulation of human DNA polymerase epsilon by MDM2. (2003) (23)
- Further characterization of a depurinated DNA-purine base insertion activity from cultured human fibroblasts. (1979) (23)
- De novo and maintenance DNA methylation by a mouse plasmacytoma cell DNA methyltransferase. (1988) (23)
- Purification of mammalian polymerases: DNA polymerase epsilon. (1995) (22)
- The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases. (2003) (22)
- Proteolysis of the human DNA polymerase ε catalytic subunit by caspase-3 and calpain specifically during apoptosis (2000) (21)
- Apurinic/apyrimidinic endonuclease activities appear normal in the CHO-cell ethyl methanesulfonate-sensitive mutant, EM9. (1984) (21)
- ACUTE AND SUBCHRONIC TOXICITY OF 2‐AMINO‐2‐HYDROXYMETHYL‐1,3‐PROPANEDIOL (1961) (21)
- The fate of p21CDKN1A in cells surviving UV-irradiation. (2005) (20)
- Further Characterization of HeLa DNA Polymerase ε (*) (1995) (18)
- Methylated oligonucleotides derived from bacteriophage fd RF‐DNA modified in vitro by E. coli B modification methylase (1973) (17)
- Further characterization of HeLa DNA polymerase epsilon. (1995) (16)
- Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains (2001) (16)
- Purification and properties of the gamma-protein specified by bacteriophage lambda: an inhibitor of the host RecBC recombination enzyme. (1973) (16)
- Stimulation of DNA Polymerase α Activity by Cdk2-Phosphorylated Rb Protein (2001) (15)
- Host-controlled restriction and modification enzymes of Escherichia coli B. (1974) (14)
- Detecting DNA damage caused by iron and hydrogen peroxide. (1994) (12)
- A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. (2002) (12)
- Efficiency of formation of pyrimidine dimers in SV40 chromatin in vitro. (1981) (12)
- Survival of apurinic SV40 DNA in the d-complementation group of xeroderma pigmentosum. (1979) (11)
- 9 Type I Restriction Enzymes (1981) (11)
- Mechanisms of action of the type-I restriction endonuclease, ecoB, and the recBC DNase from Escherichia coli. (1979) (11)
- The release of oligonucleotides by the Escherichia coli B restriction endonuclease. (1976) (10)
- DNA polymerases a, 6, and E: Three distinct enzymes from HeLa cells (10)
- XP43TO, previously classified as xeroderma pigmentosum Group E, should be reclassified as xeroderma pigmentosum variant. (2001) (10)
- 8 Deoxyribonucleases: Survey and Perspectives (1981) (10)
- Selective inhibition by harmane of the apurinic apyrimidinic endonuclease activity of phage T4-induced UV endonuclease. (1981) (10)
- Petasiphenol: a DNA polymerase lambda inhibitor. (2002) (9)
- ELECTRON MICROSCOPY OF E. coli recBC ENZYME REACTION INTERMEDIATES (1980) (9)
- MICROASSAY OF TRIS(HYDROXYMETHYL)AMINOMETHANE APPLICABLE TO BLOOD AND URINE (1961) (9)
- Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis. (2000) (9)
- Selective immunoneutralization of the multiple activities of Escherichia coli DNA polymerase I supports the model for separate active sites and indicates a complex 5' to 3' exonuclease. (1992) (9)
- ENZYMES FROM HUMAN FIBROBLASTS FOR THE REPAIR OF AP DNA (1978) (8)
- Location and nucleotide sequence of the site on SV40 DNA methylated by the ECO B modification methylase. (1974) (8)
- Coliphage HK243: Biological and Physicochemical Characteristics (1980) (7)
- Levels of uracil DNA glycosylase and AP endonuclease in murine B- and T-lymphocytes do not change with age. (1986) (7)
- The 1978 Nobel prize in physiology or medicine. (1978) (7)
- Assay for type II restriction endonucleases using the Escherichia coli recBC DNase and duplex circular DNA. (1980) (7)
- [2] Strategies and considerations for protein purifications (1990) (6)
- Strategies and considerations for protein purifications. (2009) (6)
- recBC deoxyribonuclease of Escherichia coli K-12 (1973) (6)
- WORKSHOP SUMMARY: ENZYMOLOGY OF BASE EXCISION REPAIR (1978) (6)
- In Vitro Studies of the gam Gene Product of Bacteriophage λ (1974) (6)
- Enzymatic Studies of Base Excision Repair in Cultured Human Fibroblasts and in Escherichia coli (1981) (6)
- Purification and properties of Escherichia coli endodeoxyribonuclease V. (1980) (6)
- Strategies and considerations for protein purifications. (1990) (6)
- Cisplatin-induced alterations in the expression of the mRNAs for UV-damage recognition protein. (1996) (5)
- APPENDIX B Tabulation of Some Well-characterized Enzymes with Deoyribonuclease Activity (1982) (5)
- Stimulation of DNA polymerase alpha activity by cdk2-phosphorylated Rb protein. (2001) (4)
- DNA polymerase I modulates inducible stable DNA replication in Escherichia coli (1992) (4)
- Molecular structure of exonuclease I from Escherichia coli B. (1974) (3)
- A Reduced Rate of Bulky DNA (3)
- Stimulation of human DNA polymerase e by MDM 2 (3)
- Restriction fragment analysis for differentiation of indistinguishable temperate coliphages. (1982) (3)
- A sulphoquinovosyl diacylglycerol is a DNA polymerase e inhibitor (3)
- Nucleases as reagents in the study of nucleic acid structure. (1965) (3)
- The degradation of duplex DNA by the recBC DNase of Escherichia coli. (1975) (2)
- Life in the serendipitous lane: excitement and gratification in studying DNA repair. (2012) (2)
- Killing, Stress Responses and Mutagenesis Induced in E. Coli by Hydrogen Peroxide (1989) (1)
- DNA Damage by Iron and Hydrogen Peroxide (1999) (1)
- Enzymes in Nucleic Acid Research. Michel Privat De Garilhe. Hermann, Paris; Holden-Day, San Francisco, 1968. xiv + 393 pp., illus. $16.25. Chemistry of Natural Products (1969) (1)
- APPENDIX C The Nucleases of Escherichia coli (1993) (1)
- Enzymatic studies of DNA repair. (1982) (1)
- y Cdk 2-Phosphorylated Rb Protein (2001) (0)
- Human DNA Polymerase (cid:1) Colocalizes with Proliferating Cell Nuclear Antigen and DNA Replication Late, but Not Early, in S Phase* □ S (2002) (0)
- DNA Polymerase IModulates Inducible Stable DNA Replication inEschenichia coli (1992) (0)
- Radicals in Berkeley? (2015) (0)
- Studies in vitro of the Enzyme Controlled by the recB and recC Genes of Escherichia coli K12 (1973) (0)
- Purification andProperties ofthey-Protein Specified byBacteriophage X: AnInhibitor oftheHostRecBCRecombination Enzyme (1973) (0)
- Iron associates with RTGR-containing sequences in duplex DNA: Implications for gene regulation (1998) (0)
- Bimodal Pattern ofKilling ofDNA-Repair-Defective orAnoxically GrownEscherichia coli byHydrogen Peroxide (1986) (0)
- Studies of HeLa DNA polymerases during excision-repair in vitro with DNA and chromatin substrates. (1984) (0)
- [In vitro modification of the replicative form of fd bacteriophage]. (1969) (0)
- Mending molecules: DNA Damage and Repair Vol. 1: DNA Repair in Prokaryotes and Lower Eukaryotes edited by J.A. Nickoloff and M.F. Hoekstra (1999) (0)
- Transcription of the p 125 Subunit and E 2 F 1-Activated Are Impaired in Stimulating Nuclear Import The Naturally Occurring Mutants of DDB (1999) (0)
- Two DNase-related ATPases of Escherichia coli (1973) (0)
- Eukaryotic DNA Damage Surveillance and Repair, Keith W. Caldecott. Landes/Kluwer, Georgetown, Texas (2004) (2004) (0)
- Mechanisms of dna excision repair of apurinic apyrimidinic sites (1983) (0)
- Lawrence Grossman (1924–2006) (2006) (0)
- In vitro Modifikation der replikativen Form des Bakteriophagen fd (1969) (0)
- Nucleic Acids Research Partial purification and characterization of four en dodeoxyribonuc lease activities from Escherichia coli K-12 (2005) (0)
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