Sucharit Bhakdi

Q: What Schools Are Affiliated With Sucharit Bhakdi

Sucharit Bhakdi is affiliated with the following schools: University of Freiburg, University of Mainz, University of Strasbourg, University of Newcastle , Kiel University, University of Giessen, University of Bonn

Sucharit Bhakdi's AcademicInfluence.com Rankings

Sucharit Bhakdi

Biology

#4851

World Rank

#7183

Historical Rank

Microbiology

#255

World Rank

#296

Historical Rank

biology Degrees

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Biology

Sucharit Bhakdi's Degrees

Doctorate Medicine University of Bonn
PhD Microbiology University of Bonn

Why Is Sucharit Bhakdi Influential?

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According to Wikipedia, Sucharit Bhakdi is a retired Thai-German microbiologist. In 2020 and 2021 Bhakdi became a prominent source of misinformation about the COVID-19 pandemic, claiming that the pandemic was "fake" and that COVID-19 vaccines were going to decimate the world's population.

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Sucharit Bhakdi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Alpha-toxin of Staphylococcus aureus. (1991) (708)
Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement. (2006) (467)
Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. (1998) (394)
Mechanism of membrane damage by streptolysin-O (1985) (390)
Complement and atherogenesis: binding of CRP to degraded, nonoxidized LDL enhances complement activation. (1999) (388)
Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores (1986) (346)
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O (2001) (311)
Stimulation of monokine production by lipoteichoic acids (1991) (308)
On the mechanism of membrane damage by Staphylococcus aureus alpha- toxin (1981) (307)
Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins (1996) (291)
Potassium‐inhibited processing of IL‐1 beta in human monocytes. (1995) (275)
Damage to mammalian cells by proteins that form transmembrane pores. (1987) (256)
Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation (1994) (248)
Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium. (1986) (236)
Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence (1997) (227)
On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety (1995) (217)
Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion. (1998) (210)
Membrane damage by complement. (1983) (208)
Immunopathogenesis of Atherosclerosis: Endotoxin Accelerates Atherosclerosis in Rabbits on Hypercholesterolemic Diet (2000) (207)
Protein sorting in Plasmodium falciparum-infected red blood cells permeabilized with the pore-forming protein streptolysin O. (1996) (183)
Staphylococcus aureus alpha-toxin. Dual mechanism of binding to target cells. (1991) (181)
Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. (1999) (175)
Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes (1989) (174)
Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions (1993) (167)
Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization (1998) (167)
Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion. (1997) (166)
Staphylococcal α Toxin (2000) (164)
Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles. (1981) (160)
Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits. (1989) (160)
Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesions (1990) (153)
Deposition of terminal C5b-9 complement complexes on erythrocytes and leukocytes during cardiopulmonary bypass. (1988) (150)
Damage to cell membranes by pore-forming bacterial cytolysins. (1988) (144)
Effects of Escherichia coli hemolysin on human monocytes. Cytocidal action and stimulation of interleukin 1 release. (1990) (141)
Elimination of a bacterial pore‐forming toxin by sequential endocytosis and exocytosis (2009) (140)
Enzyme-linked immunoassay for detection of PCR-amplified DNA of legionellae in bronchoalveolar fluid (1995) (140)
Potent leukocidal action of Escherichia coli hemolysin mediated by permeabilization of target cell membranes (1989) (138)
Susceptibility testing of Candida albicans and Aspergillus species by a simple microtiter menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay (1995) (134)
Minimal requirements for exocytosis. A study using PC 12 cells permeabilized with staphylococcal alpha-toxin. (1985) (133)
Possible Protective Role for C-Reactive Protein in Atherogenesis: Complement Activation by Modified Lipoproteins Halts Before Detrimental Terminal Sequence (2004) (128)
Phosphatidylserine exposure is required for ADAM17 sheddase function (2016) (123)
Staphylococcal α toxin promotes blood coagulation via attack on human platelets (1988) (123)
Molecular architecture of a toxin pore: a 15‐residue sequence lines the transmembrane channel of staphylococcal alpha‐toxin. (1996) (122)
Escherichia coli haemolysin forms voltage-dependent ion channels in lipid membranes. (1987) (122)
Noncytolytic terminal complement complexes may serve as calcium gates to elicit leukotriene B4 generation in human polymorphonuclear leukocytes. (1986) (121)
Application of C1-Esterase Inhibitor During Reperfusion of Ischemic Myocardium: Dose-Related Beneficial Versus Detrimental Effects (2001) (119)
Infectious complications during neutropenia subsequent to peripheral blood stem cell transplantation (1997) (118)
Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits. (1998) (116)
Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells. (1997) (114)
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide. (1996) (113)
Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathy. (2002) (112)
A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes (1993) (110)
Evidence That Clustered Phosphocholine Head Groups Serve as Sites for Binding and Assembly of an Oligomeric Protein Pore* (2006) (109)
Staphylococcal alpha-toxin-induced PGI2 production in endothelial cells: role of calcium. (1985) (105)
Selective killing of human monocytes and cytokine release provoked by sphingomyelinase (beta-toxin) of Staphylococcus aureus (1996) (105)
Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation. (2000) (104)
Early accumulation of the terminal complement-complex in the ischaemic myocardium after reperfusion. (1994) (104)
Complement lysis: a hole is a hole. (1991) (104)
Role of C-Reactive Protein in Atherogenesis: Can the Apolipoprotein E Knockout Mouse Provide the Answer? (2005) (102)
Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits (2009) (101)
Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O. (2006) (101)
Correlation between toxin binding and hemolytic activity in membrane damage by staphylococcal alpha-toxin (1984) (101)
Molecular nature of the complement lesion. (1978) (101)
Immunohistochemical study of the C5b-9 complex of complement in human kidneys. (1986) (100)
Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion (1989) (98)
Isolation and identification of two hemolytic forms of streptolysin-O (1984) (97)
Pore-forming toxins activate MAPK p38 by causing loss of cellular potassium. (2009) (95)
Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor (1996) (95)
Atherogenic properties of enzymatically degraded LDL: selective induction of MCP-1 and cytotoxic effects on human macrophages. (1998) (93)
Staphylococcal alpha-toxin: formation of the heptameric pore is partially cooperative and proceeds through multiple intermediate stages. (1997) (93)
Alpha-toxin of Staphylococcus aureus (1991) (90)
Helicobacter pylori: Clonal Population Structure and Restricted Transmission within Families Revealed by Molecular Typing (2000) (88)
Production of listeriolysin by beta-hemolytic strains of Listeria monocytogenes (1986) (87)
Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. (1997) (87)
Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs. (1990) (85)
Effects of Escherichia coli hemolysin on endothelial cell function (1990) (85)
Enzymatically modified, nonoxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell monolayers. (1999) (82)
Subcytocidal Attack by Staphylococcal Alpha-Toxin Activates NF-κB and Induces Interleukin-8 Production (2001) (81)
Early albumin infusion improves global and local hemodynamics and reduces inflammatory response in hemorrhagic shock (2002) (78)
C5b-9 assembly: average binding of one C9 molecule to C5b-8 without poly-C9 formation generates a stable transmembrane pore. (1986) (77)
Specific non-opiate binding sites for human β-endorphin on the terminal complex of human complement (1982) (76)
Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formation (1994) (76)
Potassium Regulates IL-1β Processing Via Calcium-Independent Phospholipase A21 (2000) (75)
Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. (1991) (75)
Coupling of Cholesterol and Cone-shaped Lipids in Bilayers Augments Membrane Permeabilization by the Cholesterol-specific Toxins Streptolysin O and Vibrio cholerae Cytolysin* (2001) (75)
Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium. (1984) (75)
Cytocidal effects of Escherichia coli hemolysin on human T lymphocytes (1993) (74)
Complement Lysis: the Ultrastructure and Orientation of the C5b‐9 Complex on Target Sheep Erythrocyte Membranes (1978) (73)
Mechanism of complement cytolysis and the concept of channel-forming proteins. (1984) (73)
Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin (1987) (71)
Detection of amphiphilic proteins and peptides in complex mixtures. Charge-shift crossed immunoelectrophoresis and two-dimensional charge-shift electrophoresis. (1977) (71)
Early Diagnosis of Acanthamoeba Infection during Routine Cytological Examination of Cerebrospinal Fluid (2006) (70)
Superoxide generation by human neutrophils induced by low doses of Escherichia coli hemolysin (1991) (70)
Recovery of human fibroblasts from attack by the pore-forming α-toxin of Staphylococcus aureus (1994) (69)
Quantitative measurement of SC5b‐9 and C5b‐9(m) in infarcted areas of human myocardium (1990) (68)
The Streptococcal Exotoxin Streptolysin O Activates Mast Cells To Produce Tumor Necrosis Factor Alpha by p38 Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Pathways (2003) (68)
Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes. (1988) (68)
Quantitative study of the binding and hemolytic efficiency of Escherichia coli hemolysin (1989) (66)
Expression of active streptolysin O in Escherichia coli as a maltose-binding-protein--streptolysin-O fusion protein. The N-terminal 70 amino acids are not required for hemolytic activity. (1996) (65)
Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs. (1989) (65)
Enzymatic Modification of Low-Density Lipoprotein in the Arterial Wall: A New Role for Plasmin and Matrix Metalloproteinases in Atherogenesis (2004) (65)
Mode of primary binding to target membranes and pore formation induced by Vibrio cholerae cytolysin (hemolysin). (1997) (64)
Potent membrane-permeabilizing and cytocidal action of Vibrio cholerae cytolysin on human intestinal cells (1997) (64)
Resealing of large transmembrane pores produced by streptolysin O in nucleated cells is accompanied by NF‐κB activation and downstream events (2002) (63)
Infarct size measurement by triphenyltetrazolium chloride staining versus in vivo injection of propidium iodide. (1997) (63)
Interaction of Escherichia coli hemolysin with biological membranes. A study using cysteine scanning mutagenesis. (2001) (63)
Relative inefficiency of terminal complement activation. (1988) (62)
Influence of the terminal complement-complex on reperfusion injury, no-reflow and arrhythmias: a comparison between C6-competent and C6-deficient rabbits. (1996) (62)
Permeabilization of the erythrocyte membrane with streptolysin O allows access to the vacuolar membrane of Plasmodium falciparum and a molecular analysis of membrane topology. (1997) (62)
Beyond cholesterol: the enigma of atherosclerosis revisited (2004) (61)
Complement complex C5b-8 induces PGI2 formation in cultured endothelial cells. (1987) (61)
Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries. (1987) (61)
Staphylococcus aureus alpha-toxin attack on human platelets promotes assembly of the prothrombinase complex. (1990) (60)
Pore‐forming Staphylococcus aureus α‐toxin triggers epidermal growth factor receptor‐dependent proliferation (2006) (60)
Binding and partial inactivation of Staphylococcus aureus alpha-toxin by human plasma low density lipoprotein. (1983) (60)
Characterization of Vibrio cholerae El Tor cytolysin as an oligomerizing pore-forming toxin (1995) (59)
Membrane-penetrating Domain of Streptolysin O Identified by Cysteine Scanning Mutagenesis* (1996) (58)
Separation of EDTA-extractable erythrocyte membrane proteins by isoelectric focussing linked to electrophoresis in sodium dodecyl sulfate (1974) (58)
Enzymatically Modified Nonoxidized Low-Density Lipoprotein Induces Interleukin-8 in Human Endothelial Cells: Role of Free Fatty Acids (2002) (58)
Interaction of complement S-protein with thrombin-antithrombin complexes: a role for the S-protein in haemostasis. (1985) (57)
The hemolysin of escherichia coli (1988) (56)
Binding of Escherichia coli Hemolysin and Activation of the Target Cells Is Not Receptor-dependent* (2005) (56)
vacA Genotypes and Genetic Diversity in Clinical Isolates of Helicobacter pylori (1998) (56)
Streptolysin O: a proposed model of allosteric interaction between a pore-forming protein and its target lipid bilayer. (1998) (56)
Membrane damage by pore-forming bacterial cytolysins. (1986) (56)
Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes. (2011) (56)
[Microbial toxins]. (1998) (55)
Why Escherichia coli α‐hemolysin induces calcium oscillations in mammalian cells‐the pore is on its own (2006) (54)
Potential protective role of apoprotein J (clusterin) in atherogenesis: Binding to enzymatically modified low-density lipoprotein reduces fatty acid-mediated cytotoxicity (2008) (54)
Immunohistochemical study of complement S protein (Vitronectin) in normal and diseased human kidneys: relationship to neoantigens of the C5b-9 terminal complex. (1989) (54)
Kinetics of streptolysin O self-assembly. (1995) (53)
Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane Fluidity* (2011) (53)
Use of a monoclonal antibody to determine the mode of transmembrane pore formation by streptolysin O (1986) (53)
Sensitive ELISA for quantitating the terminal membrane C5b-9 and fluid-phase SC5b-9 complex of human complement. (1987) (52)
Complement and atherogenesis: the unknown connection. (1998) (51)
Different forms of streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: cleavage by streptococcal cysteine protease (1995) (51)
Complement lysis: evidence for an amphiphilic nature of the terminal membrane C5b-9 complex of human complement. (1978) (51)
Staphylococcal α‐toxin: repair of a calcium‐impermeable pore in the target cell membrane (2000) (50)
Complement activation and attack on autologous cell membranes induced by streptolysin-O (1985) (50)
On the cause and nature of C9-related heterogeneity of terminal complement complexes generated on target erythrocytes through the action of whole serum. (1984) (50)
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunoblotting as a serological tool in the diagnosis of syphilitic infections (1985) (50)
Isolation of the terminal complement complex from target sheep erythrocyte membranes. (1976) (50)
Antagonistic effects of fluconazole and 5-fluorocytosine on candidacidal action of amphotericin B in human serum (1994) (50)
Sphingolipid transport from the trans‐Golgi network to the apical surface in permeabilized MDCK cells (1992) (49)
Subhemolytic doses of Escherichia coli hemolysin evoke large quantities of lipoxygenase products in human neutrophils. (1991) (49)
Flow cytometric assay for quantifying opsonophagocytosis and killing of Staphylococcus aureus by peripheral blood leukocytes (1992) (49)
Two-dimensional separation of erythrocyte membrane proteins. (1975) (49)
Interaction of the Vibrio cholerae cytolysin (VCC) with cholesterol, some cholesterol esters, and cholesterol derivatives: a TEM study. (2002) (47)
Recovery of human fibroblasts from attack by the pore-forming alpha-toxin of Staphylococcus aureus. (1994) (47)
N-terminal amino acid analysis reveal peptide heterogeneity in major electrophoretic protein components of erythrocyte ghosts. (1973) (46)
Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis. (1991) (45)
Identification of a putative membrane-inserted segment in the alpha-toxin of Staphylococcus aureus. (1994) (45)
Immunochemical analyses of membrane-bound complement. Detection of the terminal complement complex and its similarity to "intrinsic" erythrocyte membrane proteins. (1975) (44)
Streptolysin O: inhibition of the conformational change during membrane binding of the monomer prevents oligomerization and pore formation. (1999) (44)
Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases (2005) (43)
A simple immunoradiometric assay for the terminal SC5b-9 complex of human complement. (1983) (43)
Stable and Unstable Amoxicillin Resistance inHelicobacter pylori: Should Antibiotic Resistance Testing Be Performed Prior to Eradication Therapy? (1999) (42)
Fluid-phase SC5b-8 complex of human complement: generation and isolation from serum. (1981) (42)
Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186. (1993) (41)
Binding, oligomerization, and pore formation by streptolysin O in erythrocytes and fibroblast membranes: detection of nonlytic polymers (1995) (41)
Colorimetric susceptibility testing for Aspergillus fumigatus: comparison of menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide and Alamar blue tests (1996) (41)
Staphylococcal alpha-toxin: the role of the N-terminus in formation of the heptameric pore -- a fluorescence study. (1997) (41)
A Cellular Metalloproteinase Activates Vibrio cholerae Pro-cytolysin* (2004) (41)
Preparation and isolation of specific antibodies to complement components. (1983) (40)
Novel aspect of amphotericin B action: accumulation in human monocytes potentiates killing of phagocytosed Candida albicans (1994) (40)
CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b-9 attack, in human atherosclerotic lesions. (1992) (40)
Complement and atherosclerosis-united to the point of no return? (2013) (40)
No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice (2007) (40)
ADAM10 sheddase activation is controlled by cell membrane asymmetry (2019) (39)
Quantitative analysis of opsonophagocytosis and of killing of Candida albicans by human peripheral blood leukocytes by using flow cytometry (1991) (39)
Enzymatically Modified LDL Induces Cathepsin H in Human Monocytes: Potential Relevance in Early Atherogenesis (2003) (38)
Streptolysin O‐permeabilized granulocytes shed L‐selectin concomitantly with ceramide generation via neutral sphingomyelinase (2000) (38)
Platelet‐associated complement C3 in thrombocytopenic states (1983) (38)
Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation* (2012) (38)
Terminal membrane C5b-9 complex of human complement: transition from an amphiphilic to a hydrophilic state through binding of the S protein from serum (1982) (38)
Freeze-fracture analysis of the membrane lesion of human complement (1983) (37)
Leukotriene and hydroxyeicosatetraenoic acid generation elicited by low doses of Escherichia coli hemolysin in rabbit lungs (1990) (36)
The plasma membrane: Penultimate regulator of ADAM sheddase function. (2017) (36)
Membrane changes induced by exposure of Escherichia coli to human serum (1983) (36)
Human hyperimmune globulin protects against the cytotoxic action of staphylococcal alpha-toxin in vitro and in vivo (1989) (36)
Isolation of Abiotrophia adiacens from a Brain Abscess Which Developed in a Patient after Neurosurgery (1999) (36)
The terminal membrane C5b-9 complex of human complement. Evidence for the existence of multiple protease-resistant polypeptides that form the trans-membrane complement channel. (1980) (35)
Deposition of the terminal C5b‐9 complement complex on erythrocytes by human red cell autoantibodies (1983) (35)
C1‐Esterase‐Inhibitor Treatment at Early Reperfusion of Hemorrhagic Shock Reduces Mesentery Leukocyte Adhesion and Rolling (2001) (35)
Helicobacter sp. strain Mainz isolated from an AIDS patient with septic arthritis: case report and nonradioactive analysis of 16S rRNA sequence (1994) (35)
Formation of transmural complement pores in serum-sensitive Escherichia coli (1987) (35)
Possible involvement of terminal complement complex in active Heymann nephritis. (1985) (35)
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin (1994) (33)
Induction of severe vascular leakage by low doses of Escherichia coli hemolysin in perfused rabbit lungs. (1992) (33)
Altered pore-forming properties of proteolytically nicked staphylococcal alpha-toxin. (1993) (33)
Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2. (2000) (33)
[Functions and relevance of the terminal complement sequence]. (1990) (32)
Molecular weight of the membrane C5b-9 complex of human complement: characterization of the terminal complex as a C5b-9 monomer. (1981) (32)
Minimal Requirements for Exocytosis (1985) (32)
Characterization of a Catalase-Negative Methicillin-Resistant Staphylococcus aureus Strain (2007) (31)
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs. (1991) (31)
Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis (2014) (31)
Lumen geometry of ion channels formed by Vibrio cholerae EL Tor cytolysin elucidated by nonelectrolyte exclusion. (2001) (31)
Membrane damage by channel-forming proteins (1983) (31)
Local complement activation, thromboxane-mediated vasoconstriction, and vascular leakage in isolated lungs. Role of the terminal complement sequence. (1989) (30)
Functional similarity between the haemolysins of Escherichia coli and Morganella morganii. (1990) (30)
Correct oligomerization is a prerequisite for insertion of the central molecular domain of staphylococcal alpha-toxin into the lipid bilayer. (1995) (30)
Bacterial Cytolysin Perturbs Round Window Membrane Permeability Barrier In Vivo: Possible Cause of Sensorineural Hearing Loss in Acute Otitis Media (1998) (30)
Vibrio cholerae cytolysin: assembly and membrane insertion of the oligomeric pore are tightly linked and are not detectably restricted by membrane fluidity. (2000) (30)
Mast cells determine the magnitude of bacterial toxin‐induced skin inflammation (2009) (29)
Quantitative immunoelectrophoresis of proteins in human erythrocyte membranes. Analysis of protein bands obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. (1975) (29)
Immunohistochemical analysis of C3 cleavage fragments, factor H, and the C5b-9 terminal complex of complement in de novo membranous glomerulonephritis occurring in patients with renal transplant. (1986) (29)
Immunoelectrophoretic heterogeneity and cross-reactions of individual "spectrin" components isolated by preparative sodium dodecylsulfate-polyacrylamide-gel electrophoresis. (1974) (28)
Membrane insertion of the heptameric staphylococcal alpha-toxin pore. A domino-like structural transition that is allosterically modulated by the target cell membrane. (2001) (28)
Plastic foil technique attenuates inflammation in mesenteric intravital microscopy. (2000) (28)
Pathogenesis of dengue: an alternative hypothesis. (1990) (27)
Plasma C3d/C3 quotient as a parameter for in vivo complement activation. (1984) (27)
Staphylococcus aureus Bicomponent gamma-Hemolysins, HlgA, HlgB, and HlgC, Can Form Mixed Pores Containing All Components (2005) (27)
Rapid preparative isolation of major erythrocyte membrane proteins using polyacrylamide gel electrophoresis in sodium dodecylsulfate. (1975) (27)
Accumulation of Amphotericin B in Human Macrophages Enhances Activity against Aspergillus fumigatus Conidia: Quantification of Conidial Kill at the Single-Cell Level (1998) (27)
Quantitative analysis of the binding and oligomerization of staphylococcal alpha-toxin in target erythrocyte membranes (1987) (27)
Inflammatory lipid mediator generation elicited by viable hemolysin- forming Escherichia coli in lung vasculature (1990) (26)
Proteolytic transformation of SC5b-9 into an amphiphilic macromolecule resembling the C5b-9 membrane attack complex of complement. (1979) (26)
Proteinaceous bacterial toxins and pathogenesis of sepsis syndrome and septic shock: the unknown connection (1994) (26)
Pathogenesis of sepsis syndrome: possible relevance of pore-forming bacterial toxins. (1996) (25)
Identification with monoclonal antibodies of hemolysin produced by clinical isolates of Escherichia coli (1987) (24)
Interaction of human beta-endorphin with nonopiate binding sites on the terminal SC5b-9 complex of human complement. Significance of COOH-terminal beta H-endorphin fragments. (1983) (24)
Identification of a Unique HelicobacterSpecies by 16S rRNA Gene Analysis in an Abdominal Abscess from a Patient with X-Linked Hypogammaglobulinemia (2000) (24)
A simple method for quantitative measurement of C3d in human plasma. (1984) (24)
A Two‐Stage Immunoradiometric Assay with 125I‐Staphylococcal Protein A for the Detection of Antibodies and Complement on Human Blood Cells 1 (1985) (23)
Pore formation by Vibrio cholerae cytolysin follows the same archetypical mode as β‐barrel toxins from gram‐positive organisms (2009) (21)
Possible reason for preferential damage to renal tubular epithelial cells evoked by amphotericin B (1996) (21)
Does complement kill E. coli by producing transmural pores? (1986) (21)
The major "intrinsic" membrane protein of human erythrocytes. Preparative isolation and immunoelectrophoretic analyses. (1976) (21)
Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins. (1983) (20)
Complement-induced changes in the core structure of sheep erythrocyte membranes: a study by freeze-etch electron microscopy. (1974) (20)
Plasma protein loss during surgery: beneficial effects of albumin substitution. (2001) (19)
Case of fatal systemic infection with an Aureobacterium sp.: identification of isolate by 16S rRNA gene analysis (1996) (18)
Anoctamin-6 regulates ADAM sheddase function. (2018) (18)
Analysis of complement C3 activation products in human atherosclerotic lesions. (1991) (17)
Evidence suggesting the occurrence of C3‐independent intravascular immune hemolysis: Reactive hemolysis in vivo (1987) (17)
How membrane asymmetry regulates ADAM17 sheddase function (2016) (17)
GyrA sequence-based typing of Legionella (2000) (17)
Evidence for a two-domain structure of the terminal membrane C5b-9 complex of human complement. (1979) (17)
Re-incorporation of the terminal C5b-9 complement complex into lipid bilayers: formation and stability of reconstituted liposomes. (1980) (17)
Membrane damage by channel-forming proteins: staphylococcal alpha-toxin, streptolysin-O and the C5b-9 complement complex. (1985) (17)
Hydrophilic-amphiphilic transition of the terminal SC5b-8 complement complex through tryptic modification: biochemical and ultrastructural studies. (1982) (16)
Putative identification of an amphipathic α-helical sequence in hemolysin of Escherichia coli (HlyA) involved in transmembrane pore formation (2008) (16)
Pore-forming bacterial toxins and antimicrobial peptides as modulators of ADAM function (2012) (16)
Interaction between erythrocyte membrane proteins and complement components. I. The role os -S-S linkages as revealed by two-dimensional sodium dodecylsulfate-polyacrylamide gel electrophoresis. (1974) (16)
In vivo clearance studies of the terminal fluid-phase complement complex in rabbits. (1989) (16)
Simultaneous identification of campylobacters and prediction of quinolone resistance by comparative sequence analysis (1997) (16)
Pathogenesis of malaria revisited (2012) (15)
Selective permeabilization of infected host cells with pore-forming proteins provides a novel tool to study protein synthesis and viability of the intracellular apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii. (2001) (14)
Pro-inflammatory feedback activation cycle evoked by attack of Vibrio cholerae cytolysin on human neutrophil granulocytes (2008) (14)
Electroimmunoassay-immunoblotting (EIA-IB) for the utilization of monoclonal antibodies in quantitative immunoelectrophoresis: the method and its applications. (1985) (14)
Quantitation of monomeric and oligomeric forms of membrane-bound staphylococcal alpha-toxin by enzyme-linked immunosorbent assay with a neutralizing monoclonal antibody (1987) (13)
Haemolytic ‘efficiency’ of C5b‐9 complexes in drug‐induced immune haemolysis: role of cellular C5b‐9 distribution (1987) (13)
Possible hidden hazards of mass vaccination against new influenza A/H1N1: have the cardiovascular risks been adequately weighed? (2009) (13)
One-step polymerase chain reaction-based typing of Helicobacter pylori vacA gene: association with gastric histopathology (1999) (13)
Use of quantitative microbiological analyses to trace origin of contamination of parenteral nutrition solutions (2012) (13)
Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding (2017) (13)
Decomplementation antigen, a possible determinant of staphylococcal pathogenicity (1985) (13)
Role of ADAM10 and ADAM17 in Regulating CD137 Function (2021) (13)
α-Toxin permeabilized rat pheochromocytoma cells: A new approach to investigate stimulus-secretion coupling (1985) (12)
A simple method for isolating specific antibodies to complement components. (1981) (12)
Pathogenesis of Atherosclerosis: Infectious versus Immune Pathogenesis A New Concept (2000) (12)
Surgical procedure affects physiological parameters in rat myocardial ischemia: need for mechanical ventilation. (1999) (12)
Complement pore genesis observed in erythrocyte membranes by fluorescence microscopic single-channel recording. (1991) (11)
Identification of the membrane penetrating domain of Vibrio cholerae cytolysin as a β‐barrel structure (2005) (11)
Monitoring of detergent binding to amphiphilic proteins by means of micelles containing the hydrophobic dye Sudan Black B. (1980) (11)
Difference in antigenic reactivity and ultrastructure between fluid‐phase C5b‐9 and the C5b‐9 membrane attack complex of human complement (1979) (11)
Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. (2009) (10)
Interaction between erythrocyte membrane proteins and complement components. II. The identification and peptide composition of complement components C3 and C4 desorbed from erythrocyte membranes. (1974) (10)
Surgical procedure affects physiological parameters in rat myocardial ischemia: need for mechanical ventilation. (1999) (10)
Staphylococcal alpha-toxin (2004) (10)
Investigation of Sudan IV staining areas in aortas of infants and children: possible prelesional stages of atherogenesis. (2009) (10)
Infection of the upper extremity byMycobacterium marinum in a 3-year-old boy — Diagnosis by 16S-rDNA analysis (2005) (9)
The cytolytic C5b-9 complement complex: feedback inhibition of complement activation. (1988) (9)
Isolation and partial characterization of staphylococcal decomplementation antigen (1985) (9)
Biotinylation: a simple method for labelling complement component C8 with preservation of functional activity. (1989) (9)
Rapid identification of Mycobacterium marinum by comparative 16S-rRNA-gene analysis in five cases of progredient cutaneous infections (2000) (8)
Enzymatically hydrolyzed low-density lipoprotein modulates inflammatory responses in endothelial cells (2008) (8)
Molecular composition of the terminal membrane and fluid-phase C5b-9 complexes of rabbit complement. Absence of disulphide-bonded C9 dimers in the membrane complex. (1983) (8)
Staphylococcal α-toxin: the role of the N-terminus in formation of the heptameric pore — a fluorescence study1This work contains parts of the M.D. thesis of Judith Pongs.1 (1997) (8)
Functionally inactive S. aureus alpha-toxin containing a single amino acid substitution: potential usefulness as a vaccine. (1994) (8)
Proteomic Profiling of Secreted Proteins for the Hematopoietic Support of Interleukin-Stimulated Human Umbilical Vein Endothelial Cells (2013) (7)
Cysteine-specific radioiodination of proteins with fluorescein maleimide. (1997) (7)
Removal of SDS from proteins for immunochemical analyses: a simple method utilizing ultracentrifugation in sucrose density gradients containing non-ionic detergent. (1980) (7)
Pathogenesis of Atherosclerosis: Infectious versus Immune Pathogenesis (2000) (7)
Detection of Membrane‐Bound Complement Components by Crossed Immunoelectrophoresis of Target Membranes Solubilized with Non‐Ionic Detergent (1975) (7)
Correlation BetweenToxinBinding andHemolytic Activity in MembraneDamagebyStaphylococcal oa-Toxin (1984) (7)
A reason for the cytolytic inefficiency of murine serum. (1987) (7)
Endotoxin accelerates atherosclerosis independent of complement activation. (2009) (7)
Bacteria and bacterial exotoxins induce leukotriene formation from human polymorphonuclear granulocytes. (1983) (6)
In-situ complement activation, pulmonary hypertension and vascular leakage in rabbit lungs--the role of the terminal complement complex. (1989) (6)
Mutagenesis of the ADAM17-phosphatidylserine–binding motif leads to embryonic lethality in mice (2019) (6)
[An alternative hypothesis of the pathogenesis of atherosclerosis]. (1998) (6)
Escherichia coli hemolysin causes thromboxane-mediated hypertension and vascular leakage in rabbit lungs. (1989) (5)
Interaction of human beta-endorphin with the terminal SC5b-9 and "preterminal" SC5b-7 and SC5b-8 complexes of human complement. (1982) (5)
An hypothesis for the immunopathogenesis of atherosclerosis. (2003) (5)
Terminal complement complex and endothelial cells. (1989) (5)
[Immunohistochemical C5b-9-complement complex demonstration in early stages of myocardial necroses using paraffin sections]. (1990) (4)
Scramblases as Regulators of Proteolytic ADAM Function (2022) (4)
Positive camp-phenomenon elicited by coagulase-negative staphylococci (2005) (4)
Bacterial Exotoxins and Sepsis (1994) (4)
Flow cytometric assay for estimating fungicidal activity of Amphotericin B in human serum (2004) (4)
[Molecular basis for the pathogenicity of S. aureus alpha-toxins]. (1984) (3)
Damage to the Host by Channel-Forming Bacterial Toxins (1985) (3)
Proteinaceous bacterial toxins and pathogenesis of sepsis syndrome and septic shock: the unknown connection (2004) (3)
[Studies on cathepsin B': specificity and properties]. (1969) (3)
Bacterial Exotoxins and Vascular Injury (1993) (3)
Pore‐Forming Toxins (2008) (3)
In vivo effects of intravascularly applied Escherichia coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys (1993) (3)
Isolation andIdentification ofTwoHemolytic FormsofStreptolysin-O (1984) (3)
Membrane Insertion of the Heptameric Staphylococcal α-Toxin Pore (2001) (3)
Reaction of partial identity between the C56-9 complex derived from target membranes and from inulin-activated serum. (1977) (3)
Freeze-fracture analysis of the membrane lesion of complement (1982) (3)
A natural auto-inhibitory factor of the terminal complement pathway in serum of Ctenodactylus gondi. (1987) (2)
The Pfizer mRNA vaccine: pharmacokinetics and toxicity (2021) (2)
MEMBRANE DAMAGE BY COMPLEMENT COMPONENTS C5b-C9: BIOCHEMICAL AND ULTRASTRUCTURAL STUDIES (1983) (2)
Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function (2022) (2)
Functions and relevance of the terminal complement sequence (2005) (2)
Prions, mad cow disease, and preventive measures: a critical appraisal (2003) (2)
Bacterial Cytolysins that Form Transmembrane Pores (1987) (1)
AbstractsMolecular properties of fluid-phase SC5b-8 and membrane C5b-8(m) complexes of human complement (1982) (1)
Toxins and their possible role in the pathogenesis of bacterial endocarditis (1987) (1)
Experimental autoimmune neuropathy and anti-gangliosides antibodies (1991) (1)
Melittin Modulates Keratinocyte Function through P2 (2012) (1)
Mechanisms of invasion and persistence of infectious agents (2012) (1)
Pathogenesis of atherosclerosis: an alternative hypothesis (1998) (1)
Some new developments in clinical mycology : applications for flow cytometry (1993) (1)
[40] Incorporation of toxin pores into liposomes (1988) (1)
Human monocytes and polymorphonuclear granulocytes (PMN) differ in their lipid species pattern and their pathologic lipidomic response upon E-LDL loading (2009) (1)
[Structure and mode of action of bacterial toxins]. (1983) (1)
[Mechanism of cell damage by E. coli hemolysin]. (1988) (1)
PCR-amplified DNA of legionellae in Enzyme-linked immunoassay for detection of (1995) (1)
degradation.evoke internucleosomal DNA pores created by staphylococcal alpha-toxin in Novel path to apoptosis: small transmembrane (2013) (0)
Quantitative Analysis ofOpsonophagocytosis andofKilling of Candida albicans byHumanPeripheral BloodLeukocytes by UsingFlowCytometry (2013) (0)
The PrtV protease in Vibrio cholerae influenses expression of the VCC/HlyA cytolytic activity (2010) (0)
The terminal cytolytic C5b-9(m) complex of human complement: Transition from an amphiphilic to a hydrophilic state through binding of the s-protein from serum (1982) (0)
Atherosclerosis: Why the search for a causative infectious agent is not warranted (2000) (0)
Passive hemagglutination test for detection of antibodies to streptolysin O (2005) (0)
Pore-forming bacterial toxins and antimicrobial peptides as modulators of ADAM function (2012) (0)
Table of Contents (1995) (0)
PO12-321 DIFFERENTIAL SUSCEPTIBILITY OF HUMAN GRANULOCYTES AND MACROPHAGES TO ENZYMATICALLY MODIFIED LDL (2007) (0)
The Participation of the Complement System in Atherosclerotic Vascular Disease (1991) (0)
Vibrio cholerae cytolysin causes an inflammatory response in human intestinal cells that is modulated by the protease PrtV secreted by the same bacterium (2009) (0)
Alteration of membrane proteins as a possible cause of stomatocytosis (1974) (0)
Expert statement regarding Comirnaty—COVID-19-mRNA-Vaccine for children (2021) (0)
Stimulation of interleukin-1β release from human monocytes by the action of pore-forming bacterial toxins (1992) (0)
Human Endothelial Cells : Role of Free Fatty Acids Enzymatically Modified Nonoxidized Low-Density Lipoprotein Induces Interleukin-8 in (2002) (0)
Complement Activation andAttack on Autologous CellMembranes Induced byStreptolysin-O (1985) (0)
PO5-154 RABBIT CRP TRANSGENE EXPRESSION CAUSES ACCELERATED ATHEROSCLEROSIS IN MALE LDLR−/− MICE (2007) (0)
PO2-53 APOLIPOPROTEIN J (CLUSTERIN) BINDS TO AND REDUCES CYTOTOXICITY OF ENZYMATICALLY HYDROLYZED LOW DENSITY LIPOPROTEIN (2007) (0)
Bacterial Exotoxins and Acute Lung Failure (1991) (0)
Mechanisms of invasion and persistence of infectious agents (2012) (0)
2 Calcium-Independent Phospholipase A Processing Via b Potassium Regulates IL-1 (2000) (0)
Stimulation of pulmonary vascular arachidonic acid cascade by staphylococcal α-toxin: Inititiation by Ca-flux possibly through transmembrane toxin-channels (1984) (0)
[Presence of the terminal complement activation complex (C5b-9) on cell remnants within connective matrices of normal human kidney]. (1983) (0)
Use of quantitative microbiological analyses to trace origin of contamination of parenteral nutrition solutions (2012) (0)
Pathogenesis of malaria revisited (2012) (0)
Strategies for Survival of Extracellular Pathogens (2002) (0)
Possible Relevance of Bacterial Exotoxins in the Pathogenesis of Septic Shock (2019) (0)
93 CONTRACTILITY AND CORONARY FLOW IN ISOLATED PERFUSED RABBIT HEARTS (1995) (0)
Incorporation of toxin pores into liposomes. (1988) (0)
Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis (2014) (0)
[What constitutes staphylococcal disease?]. (1987) (0)
human interleukin-6 receptor. active form exemplified by studies with the membrane-anchored molecules in biologically metalloproteinases: liberation of Novel pathogenic mechanism of microbial (2013) (0)
Membrane lesion of complement (1980) (0)
Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications (2021) (0)
The cytolytic C 5 b9 complement complex : Feedback inhibition of complement activation ( complement regulation / C 3 convertase formation ) (0)
Response to Letter Regarding Article, “Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits” (2010) (0)
Evidence foratwo-domain structure oftheterminal membrane C5b-9complex ofhumancomplement (1979) (0)
[Immunopathogenesis of atherosclerosis: the Mainz hypothesis]. (2002) (0)
Formation of protein channels in target membranes. (1985) (0)
Déficit homozygote en C6 révélé par une infection à streptocoque A. (1986) (0)
Membrane-Damaging Toxins and Inflammation (1999) (0)
Staphylococcal a-toxin: Oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles (toxin -membrane interaction/hydrophili-amnphiphilic protein transition/transmembrane pore/protein-detergent (0)
efficiency of Escherichia coli hemolysin. Quantitative study of the binding and hemolytic (2013) (0)
PO9-231 ENZYMATICALLY HYDROLYZED LOW DENSITY LIPOPROTEIN MODULATES INFLAMMATORY RESPONSE IN ENDOTHELIAL CELLS (2007) (0)
Quantitative evaluation oftheterminal C5b-9complement complex byELISAinhumanatherosclerotic arteries (1987) (0)
Mechanism of cell lysis caused by Escherichia coli hemolysin (2000) (0)
IL-6 and Its Soluble Receptor Creates an Autocrine Activation Loop by Muscle Cells: Up-Regulation of gp130 Novel Path to Activation of Vascular Smooth (1999) (0)
[Immunopathogenesis of atherosclerosis: the Mainz hypothesis]. (2006) (0)
[Homozygous C6 deficiency disclosed by Streptococcus A infection]. (1986) (0)

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