Sündüz Keleş
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Professor of Statistics and Biostatistics, University of Wisconsin
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Sündüz Keleşmathematics Degrees
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Statistics
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Why Is Sündüz Keleş Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sündüz Keleş is a Turkish statistician specializing in statistical methods in genomics. She is a professor of statistics and of biostatistics and medical informatics at the University of Wisconsin–Madison. Her research has included the development of the FreeHi-C system for generating synthetic Hi-C data.
Sündüz Keleş's Published Works
Published Works
- Sparse partial least squares regression for simultaneous dimension reduction and variable selection (2010) (743)
- Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. (2009) (344)
- Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma (2010) (274)
- GATA Switches as Developmental Drivers* (2010) (250)
- The bone morphogenetic protein 1/Tolloid-like metalloproteinases. (2007) (235)
- Asymptotic Optimality of Likelihood-Based Cross-Validation (2004) (208)
- Rho directs widespread termination of intragenic and stable RNA transcription (2009) (185)
- Effects of Sleep and Wake on Oligodendrocytes and Their Precursors (2013) (172)
- Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. (2012) (172)
- Genome-scale Analysis of Escherichia coli FNR Reveals Complex Features of Transcription Factor Binding (2013) (164)
- Chemical-genomic dissection of the CTD code (2010) (162)
- Sparse Partial Least Squares Classification for High Dimensional Data (2010) (162)
- Identification of regulatory elements using a feature selection method (2002) (128)
- A Statistical Framework for the Analysis of ChIP-Seq Data (2011) (118)
- Autophagy Driven by a Master Regulator of Hematopoiesis (2011) (112)
- Transcription of histone gene cluster by differential core-promoter factors. (2007) (106)
- Expression Quantitative Trait Loci Mapping With Multivariate Sparse Partial Least Squares Regression (2009) (104)
- Expression Profiling of GABAergic Motor Neurons in Caenorhabditis elegans (2005) (104)
- Normalization of ChIP-seq data with control (2012) (98)
- Genetic framework for GATA factor function in vascular biology (2011) (97)
- Dynamic Regulation of Schwann Cell Enhancers after Peripheral Nerve Injury* (2015) (92)
- Discovering Transcription Factor Binding Sites in Highly Repetitive Regions of Genomes with Multi-Read Analysis of ChIP-Seq Data (2011) (91)
- Supervised Detection of Conserved Motifs in DNA Sequences with Cosmo (2007) (83)
- Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve (2012) (80)
- Perspectives on ENCODE (2020) (79)
- Detecting differential binding of transcription factors with ChIP-seq (2012) (78)
- Recurrent events analysis in the presence of time‐dependent covariates and dependent censoring (2004) (77)
- Differential Sox10 genomic occupancy in myelinating glia (2015) (77)
- Identification of Estrogen Receptor Dimer Selective Ligands Reveals Growth-Inhibitory Effects on Cells That Co-Express ERα and ERβ (2012) (75)
- Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis (2008) (66)
- Multiple Testing Methods For ChIP - Chip High Density Oligonucleotide Array Data (2006) (66)
- Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes (2015) (66)
- atSNP: transcription factor binding affinity testing for regulatory SNP detection (2015) (66)
- Regulatory motif finding by logic regression (2004) (65)
- Dynamic Changes in Nucleosome Occupancy Are Not Predictive of Gene Expression Dynamics but Are Linked to Transcription and Chromatin Regulators (2012) (64)
- jMOSAiCS: joint analysis of multiple ChIP-seq datasets (2013) (60)
- Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. (2020) (60)
- Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond (2018) (59)
- Framework for kernel regularization with application to protein clustering. (2005) (59)
- Residual‐based tree‐structured survival analysis (2002) (57)
- O2 availability impacts iron homeostasis in Escherichia coli (2017) (56)
- Novel TRF1/BRF target genes revealed by genome‐wide analysis of Drosophila Pol III transcription (2007) (50)
- Research resource: global identification of estrogen receptor β target genes in triple negative breast cancer cells. (2013) (49)
- Exploratory and Confirmatory Gene Expression Profiling of mac1Δ* (2004) (48)
- Mixture Modeling for Genome‐Wide Localization of Transcription Factors (2007) (47)
- A single C. elegans PUF protein binds RNA in multiple modes. (2009) (45)
- Impact of Anaerobiosis on Expression of the Iron-Responsive Fur and RyhB Regulons (2015) (45)
- Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress (2016) (43)
- Locus‐wide identification of Egr2/Krox20 regulatory targets in myelin genes (2010) (42)
- Divergence of Pumilio/fem-3 mRNA Binding Factor (PUF) Protein Specificity through Variations in an RNA-binding Pocket* (2011) (40)
- A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets (2008) (39)
- Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome (2016) (38)
- Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites (2015) (38)
- Differentially Methylated Plasticity Genes in the Amygdala of Young Primates Are Linked to Anxious Temperament, an at Risk Phenotype for Anxiety and Depressive Disorders (2014) (37)
- Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22. (2012) (34)
- Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase (2019) (34)
- Predicting gene expression in massively parallel reporter assays: A comparative study (2017) (34)
- Supervised Detection of Regulatory Motifs in DNA Sequences (2003) (34)
- CMARRT: A Tool of Analysis of CHIP-chip Data from Tiling Arrays by Incorporating the Correlation Structure (2007) (33)
- Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism. (2015) (31)
- Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome. (2015) (31)
- Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells (2016) (30)
- GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. (2018) (27)
- Mixture models with multiple levels, with application to the analysis of multifactor gene expression data. (2008) (25)
- Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer (2019) (25)
- Loss-based estimation with cross-validation: applications to microarray data analysis (2003) (24)
- Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress (2016) (23)
- Statistical analysis of ChIP-seq data with MOSAiCS. (2013) (23)
- Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle (2019) (22)
- Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. (2014) (22)
- GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. (2017) (21)
- CTCF loss mediates unique DNA hypermethylation landscapes in human cancers (2020) (21)
- Transient Genotype-by-Environment Interactions Following Environmental Shock Provide a Source of Expression Variation for Essential Genes (2010) (21)
- Angiogenesis Induced by Signal Transducer and Activator of Transcription 5A (STAT5A) Is Dependent on Autocrine Activity of Proliferin* (2011) (20)
- A Non-Homogeneous Hidden-State Model on First Order Differences for Automatic Detection of Nucleosome Positions (2009) (19)
- Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis (2015) (18)
- Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies (2019) (18)
- The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms. (2016) (17)
- atSNP Search: a web resource for statistically evaluating influence of human genetic variation on transcription factor binding (2018) (17)
- Integrative analysis with ChIP-seq advances the limits of transcript quantification from RNA-seq (2016) (17)
- dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data (2013) (16)
- Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories (2020) (16)
- CSI-Tree: a regression tree approach for modeling binding properties of DNA-binding molecules based on cognate site identification (CSI) data (2008) (15)
- A Phylogenetic Mixture Model for the Evolution of Gene Expression (2009) (14)
- A statistical framework for power calculations in ChIP-seq experiments (2014) (13)
- Asymptotically optimal model selection method with right censored outcomes (2004) (13)
- Discovering How Heme Controls Genome Function Through Heme-omics. (2020) (13)
- Estimating Tree-Structured Covariance Matrices via Mixed-Integer Programming (2009) (12)
- GLANET: genomic loci annotation and enrichment tool (2017) (12)
- Perm-seq: Mapping Protein-DNA Interactions in Segmental Duplication and Highly Repetitive Regions of Genomes with Prior-Enhanced Read Mapping (2015) (12)
- Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder (2019) (11)
- Bioinformatic analysis of neural stem cell differentiation. (2007) (11)
- CNV-guided multi-read allocation for ChIP-seq (2014) (10)
- An Introduction to the ‘spls’ Package, Version 1.0 (2008) (10)
- Integrating quantitative information from ChIP-chip experiments into motif finding. (2008) (10)
- MOSAiCS-HMM: A Model-Based Approach for Detecting Regions of Histone Modifications from ChIP-Seq Data (2014) (9)
- FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation (2019) (9)
- Epigenetic and genetic mechanisms in red cell biology (2014) (9)
- The SWI/SNF-Related, Matrix Associated, Actin-Dependent Regulator of Chromatin A4 Core Complex Represses Respiratory Syncytial Virus-Induced Syncytia Formation and Subepithelial Myofibroblast Transition (2021) (9)
- Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (2020) (8)
- Comments on: Augmenting the bootstrap to analyze high dimensional genomic data (2008) (8)
- GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism (2020) (8)
- RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma. (2017) (7)
- Identification of direct transcriptional targets of NFATC2 that promote β-cell proliferation. (2021) (7)
- SURF: integrative analysis of a compendium of RNA-seq and CLIP-seq datasets highlights complex governing of alternative transcriptional regulation by RNA-binding proteins (2020) (7)
- PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability (2021) (7)
- Systematic evaluation of the impact of ChIP-seq read designs on genome coverage, peak identification, and allele-specific binding detection (2016) (6)
- An empirical Bayes test for allelic‐imbalance detection in ChIP‐seq (2018) (6)
- Estimation of the Bivariate Survival Function with Generalized Bivariate Right Censored Data Structures (2003) (5)
- Normalization and De-noising of Single-cell Hi-C Data with BandNorm and 3DVI (2021) (4)
- Annotation Regression for Genome-Wide Association Studies with an Application to Psychiatric Genomic Consortium Data (2016) (3)
- A Linear Mixed Effects Clustering Model for Multi-species Time Course Gene Expression Data 1 (2008) (3)
- Normalization and de-noising of single-cell Hi-C data with BandNorm and scVI-3D (2022) (3)
- eQTL Mapping for Functional Classes of Saccharomyces cerevisiae Genes with Multivariate Sparse Partial Least Squares Regression (2011) (3)
- A Hierarchical Semi-Markov Model for Detecting Enrichment with Application to ChIP-Seq Experiments (2009) (3)
- In Silico Pooling of ChIP-seq Control Experiments (2014) (2)
- FreeHi-C Spike-in Simulations for Benchmarking Differential Chromatin Interaction Detection. (2020) (2)
- Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer (2022) (2)
- RNA-Binding Protein IGF 2 BP 1 in Cutaneous Squamous Cell Carcinoma (2017) (2)
- A Hierarchical Framework for State-Space Matrix Inference and Clustering. (2015) (2)
- Multivariate Boosting for Integrative Analysis of High-Dimensional Cancer Genomic Data (2014) (2)
- Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders (2021) (2)
- INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants (2021) (2)
- scGAD: single-cell gene associating domain scores for exploratory analysis of scHi-C data (2021) (2)
- Data exploration, quality control and statistical analysis of ChIP-exo/nexus experiments (2017) (2)
- PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments (2019) (1)
- Declined presentation hematopoietic signaling mechanism revealed from a stem/progenitor cell cistrome (2015) (1)
- iFunMed: Integrative functional mediation analysis of GWAS and eQTL studies (2019) (1)
- Generative Modeling of Multi-mapping Reads with mHi-C Advances Analysis of High Throughput Genome-wide Conformation Capture Studies (2018) (1)
- Kernel Regularization and Dimension Reduction (2006) (1)
- Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks (2023) (1)
- Annotation Regression for Genome-Wide Association Studies with an Application to Psychiatric Genomic Consortium Data (2017) (1)
- Multiple Tests of Association with Biological (2006) (1)
- jMOSAiCS: joint analysis of multiple ChIP-seq datasets (2013) (1)
- atSNPInfrastructure, a Case Study for Searching Billions of Records While Providing Significant Cost Savings over Cloud Providers (2018) (1)
- Processed data and analysis results for 104 RBPs (2020) (1)
- Unbiased screen of RNA tailing enzymes at single-nucleotide resolution reveals a poly(UG) polymerase required for genome integrity and RNA silencing (2018) (1)
- MLG: multilayer graph clustering for multi-condition scRNA-seq data (2021) (1)
- TRAID-seq: Unbiased analysis of RNA tailing enzyme activity at single-nucleotide resolution (2019) (1)
- Biometrics , 1 – 17 Mixed Effects Tests of Covariance Structure in Neutral Evolution Inference (2012) (0)
- Latent infection of B lymphocytes by Epstein-Barr virus (EBV) in vitro results in their immortalization (2015) (0)
- Supplementary Materials for ‘ GLANET : Genomic Loci ANnotation and Enrichment Tool ’ (2017) (0)
- crystal structure of FBF-2 in complex with gld-1 FBEa13 RNA (2012) (0)
- Author response: Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies (2018) (0)
- Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase (2019) (0)
- Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue (2022) (0)
- 1008 – FROM GATA2 HUMAN GENETICS TO LEUKEMIA PREDISPOSITION-GENERATING NETWORKS (2022) (0)
- Statistical Methods for Profiling 3-Dimensional Chromatin Interactions from Repetitive Regions of Genomes (2018) (0)
- crystal structure of FBF-2 in complex with a mutant gld-1 FBEa13 RNA (2012) (0)
- GATA2-Dependent Developmental and Regenerative Networks (2019) (0)
- Exploratory and Confirmatory Gene Expression Profiling of mac1 (cid:1) * □ S (2004) (0)
- FreeHi-C: high fidelity Hi-C data simulation for benchmarking and data augmentation (2019) (0)
- Genome analysis GLANET: genomic loci annotation and enrichment tool (2017) (0)
- Abstract 4434: CTCF acts as a master regulator to direct epigenetic events important for tumor development and progression (2016) (0)
- CSSP : ChIP-Seq Statistical Power (2013) (0)
- SURF: integrative analysis of a compendium of RNA-seq and CLIP-seq datasets highlights complex governing of alternative transcriptional regulation by RNA-binding proteins (2020) (0)
- Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (2020) (0)
- Enhancer mechanisms governing developmental and regenerative hematopoietic programs (2017) (0)
- Transcription and Chromatin Regulators Expression Dynamics but Are Linked to Occupancy Are Not Predictive of Gene Dynamic Changes in Nucleosome (2013) (0)
- AdaLiftOver: high-resolution identification of orthologous regulatory elements with Adaptive liftOver (2022) (0)
- MuDCoD: Multi-Subject Community Detection in Personalized Dynamic Gene Networks from Single Cell RNA Sequencing (2021) (0)
- mHi-C: robust leveraging of multi-mapping reads in Hi-C analysis (2018) (0)
- ccosmo: A stand-along C program for the supervised detection of conserved motifs in DNA sequences. (2006) (0)
- Joint tensor modeling of single cell 3D genome and epigenetic data with Muscle (2023) (0)
- FreeHi-C simulates high-fidelity Hi-C data for benchmarking and data augmentation (2019) (0)
- Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master 1 (2008) (0)
- Declined Presentation: From a hematopoietic stem cell cistrome to novel regulators of hematopoiesis (2014) (0)
- Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (2020) (0)
- Author Correction: Perspectives on ENCODE (2022) (0)
- Correction to: Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny (2020) (0)
- SAMD14 enhancer-mediated hematopoietic stress signaling (2016) (0)
- GATA/Heme Multi-Omics Reveals a Trace Metal-Dependent Erythrocyte Developmental Mechanism (2018) (0)
- Normalization of ChIP-seq data with control (2012) (0)
- Dozer: Debiased personalized gene co-expression networks for population-scale scRNA-seq data (2023) (0)
- INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants (2021) (0)
- Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes (2022) (0)
- Genetic Determinants of the Definitive Hematopoietic Stem/Progenitor Cell Compartment (2012) (0)
- Divergence of PUF protein specificity through variations in an RNA-binding pocket (2012) (0)
- Abstract 2083: A single tyrosine in a PUF RNA binding protein controls its mRNA binding landscape and separates its distinct biological functions (2023) (0)
- Bur1 kinase places new phosphorylation marks in RNA pol II CTD in the 3' region of genes (2010) (0)
- Systematic evaluation of the impact of ChIP-seq read designs on genome coverage, peak identification, and allele-specific binding detection (2016) (0)
- A MAD-Bayes Algorithm for State-Space Inference and Clustering with Application to Querying Large Collections of ChIP-Seq Data Sets (2016) (0)
- CTCF loss mediates unique DNA hypermethylation landscapes in human cancers (2020) (0)
- Enhancing motif finding models using multiple sources of genome-wide data (2011) (0)
- cosmoweb: A web application for the supervised detection of conserved motifs in DNA sequences. (2006) (0)
- Analysis of ChIP-seq Data with ‘ mosaics ’ Package : MOSAiCS and MOSAiCS-HMM (2010) (0)
- Cistrome Control of Hematopoieitic Stem/Progenitor Cell Function (2015) (0)
- Materials to “ A Non-Homogeneous Hidden Markov Model on First Order Differences for Automatic Detection of Nucleosome Positions ” (2008) (0)
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