Suranganie Dharmawardhane
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Most Influential Person Now
Sri Lankan biochemist
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Suranganie Dharmawardhanebiology Degrees
Biology
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Biochemistry
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#2674
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Biology
Suranganie Dharmawardhane's Degrees
- Bachelors Chemistry University of Colombo
- PhD Biochemistry University of Colombo
Why Is Suranganie Dharmawardhane Influential?
(Suggest an Edit or Addition)According to Wikipedia, Suranganie Dharmawardhane Flanagan is a Sri Lankan molecular biologist and biochemist. She is a professor of biochemistry at the University of Puerto Rico School of Medicine. Education In 1980, Dharmawardhane completed a B.S. at University of Colombo. She earned a M.S. at Northeastern University in 1984. She completed a Ph.D. at University of Massachusetts Amherst in 1987. Her dissertation was titled Light-stimulated transplasmalemma electron transport in oat mesophyll cells. She conducted postdoctoral training at Albert Einstein College of Medicine under .
Suranganie Dharmawardhane's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of an actin-binding protein from Dictyostelium as elongation factor 1a (1990) (344)
- Regulation of macropinocytosis by p21-activated kinase-1. (2000) (303)
- Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells (1997) (249)
- Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase* (2012) (188)
- Targeting Rac and Cdc42 GTPases in Cancer. (2018) (150)
- Flavonoid effects relevant to cancer. (2002) (135)
- Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. (2008) (131)
- Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells (2005) (130)
- Isolation of an abundant 50,000-dalton actin filament bundling protein from Dictyostelium amoebae. (1990) (111)
- Localization of p21‐activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils (1999) (109)
- Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. (2007) (97)
- Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells. (2005) (95)
- Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols (2009) (93)
- Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade (2016) (87)
- Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein (2016) (87)
- Compartmentalization and actin binding properties of ABP-50: the elongation factor-1 alpha of Dictyostelium. (1991) (85)
- Mechanisms of amoeboid chemotaxis: an evaluation of the cortical expansion model. (1990) (78)
- Individual and combined soy isoflavones exert differential effects on metastatic cancer progression (2010) (70)
- Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation (1989) (68)
- Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer (2012) (63)
- Ganoderma lucidum (Reishi) Inhibits Cancer Cell Growth and Expression of Key Molecules in Inflammatory Breast Cancer (2011) (62)
- Changes in the association of actin-binding proteins with the actin cytoskeleton during chemotactic stimulation of Dictyostelium discoideum. (1989) (59)
- In vitro analysis of the invasive phenotype of SUM 149, an inflammatory breast cancer cell line (2005) (58)
- The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model (2014) (56)
- Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer (2017) (56)
- A Far-red Fluorescent Contrast Agent to Image Epidermal Growth Factor Receptor Expression (2004) (55)
- Targeting Rac and Cdc42 GEFs in Metastatic Cancer (2020) (50)
- Rho GTPases and leukocyte cytoskeletal regulation (1997) (39)
- Novel inhibitors of Rac1 in metastatic breast cancer. (2010) (36)
- Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. (2013) (35)
- Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice (2013) (35)
- Molecular optical imaging of therapeutic targets of cancer. (2006) (35)
- Regulatory role of the G alpha 1 subunit in controlling cellular morphogenesis in Dictyostelium. (1994) (30)
- BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion. (2015) (26)
- Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer. (2018) (26)
- The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G* (2012) (23)
- Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry. (2015) (22)
- Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium. (1992) (21)
- Triterpene saponins from Silphium radula. (2008) (21)
- Development of EHop-016: a small molecule inhibitor of Rac. (2013) (20)
- Protective effects of eicosapentaenoic acid in adipocyte-breast cancer cell cross talk. (2019) (16)
- Analysis of cell movement and signalling during ring formation in an activated G alpha1 mutant of Dictyostelium discoideum that is defective in prestalk zone formation. (1997) (16)
- Near real-time in vivo confocal imaging of mouse mammary tumors. (2002) (15)
- Developmentally regulated changes in 1,2-diacylglycerol in Dictyostelium. Regulation by light and G proteins. (1993) (14)
- Spatial and temporal expression of the Dictyostelium discoideum G alpha protein subunit G alpha 2: expression of a dominant negative protein inhibits proper prestalk to stalk differentiation. (1994) (12)
- Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G* (2015) (11)
- Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal alpha-mannosidase gene in Dictyostelium discoideum. (1993) (10)
- In situ analysis of breast cancer progression in murine models using a macroscopic fluorescence imaging system (2006) (10)
- Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry (2019) (7)
- The addition of a pregnenolone pendant group enhances the anticancer properties of titanocene dichloride in a mcf-7 xenograft model. (2014) (6)
- Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer (2021) (6)
- Novel Inhibitors of Rac 1 in Metastatic Breast Cancer (2010) (5)
- Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae (2018) (5)
- Synthesis, Anti-Cancer and Anti-Migratory Evaluation of 3,6-Dibromocarbazole and 5-Bromoindole Derivatives (2019) (4)
- Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice (2020) (4)
- Near real-time in vivo confocal imaging of mouse mammary tumors (2002) (3)
- Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer (2020) (3)
- Downregulation of miR‐155 Contributes to The Anti‐proliferative Effects of The Soy Isoflavone Genistein in Estrogen Receptor Negative Breast Cancer (2015) (2)
- Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women (2021) (2)
- Role of Soy Phytoestrogens Genistein and Daidzein in Focal Adhesion Assembly and Focal Adhesion Kinase Activity in Breast Cancer Cells (2005) (2)
- Rho Family GTPases in Cancer (2021) (2)
- Adipocyte‐Breast Cancer Cell Interactions: Preventive Effects of Omega‐3 Fatty Acids (2015) (1)
- Novel Rac Inhibitors as Targeted Therapeutics for Metastatic Breast Cancer (2018) (1)
- A far‐red fluorescent contrast agent to image epidermal growth factor receptor expression (2004) (1)
- Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico (2020) (1)
- Potential of grape polyphenols as breast cancer therapeutics (2013) (1)
- Sensitization of Anti‐EGFR/HER2 Targeted Therapy Resistance in Breast Cancer Cells by MiRNA Manipulation (2019) (1)
- Abstract A057: Therapeutic potential of genistein via targeting the microRNA miR-155 in breast cancer (2013) (1)
- Regulation of Akt/AMPK/mTOR signaling by grape polyphenols in triple negative breast cancer (2013) (1)
- MicroRNAs as a Novel Mechanism by which Eicosapentaenoic Acid Mediates Inflammation in Diet‐Induced Obesity (2016) (0)
- Abstract 1988: Increased expression of eukaryotic protein synthesis initiation factor eIF4G by the daidzein metabolite equol may contribute to breast cancer malignancy (2012) (0)
- Inhibition of the Rho GTPase Rac by resveratrol may modulate cell surface actin structures in breast cancer cells (2006) (0)
- Abstract 347: Comparative activity of MBQ-167 metabolites in metastatic breast cancer (2022) (0)
- Abstract P2-01-05: MBQ-167 chemosensitizes triple-negative breast cancer cells to current chemotherapies and reduces paclitaxel-induced metastasis (2023) (0)
- Overcoming Resistance to Anti‐EGFR Therapy in Breast Cancer with Rac Inhibitors (2017) (0)
- The dual Rac/Cdc42 inhibitor EHop-167 as a breast cancer therapeutic (2016) (0)
- Abstract 2462: Rac and p-PAK expression among Puerto Rican breast cancer patients (2022) (0)
- Abstract A16: Molecular mechanisms of EGFR therapy resistance in breast cancer cells (2012) (0)
- Abstract A141: A novel inhibitor of malignant signaling in metastatic breast cancer (2015) (0)
- Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer (2021) (0)
- Abstract 2622: Targeting Rac/Cdc42 GTPases to overcome HER2-targeted therapy resistance (2023) (0)
- Abstract 4923: Pharmacokinetics of the metastatic cancer inhibitor MBQ-167 in mice (2018) (0)
- Abstract 1824: Mechanisms of resistance to anti-EGFR/HER2 therapy in breast cancer (2018) (0)
- Abstract B29: Anti-breast cancer effects of the Vav/Rac inhibitor Ehop-016 in the tumor microenvironment (2016) (0)
- Abstract 2185: Efficacy of Rac/Cdc42 inhibitors in multiple cancer models (2019) (0)
- Abstract 2197: Characterization of immunoliposomes as delivery vehicles for the Rac inhibitor Ehop-016 in HER2 type breast cancer (2017) (0)
- Rapid quantification of resveratrol in mouse plasma by ultra high pressure liquid chromatography (UPLC) coupled to tandem mass spectrometry. (2014) (0)
- Abstract 4228: Ganoderma lucidum (Reishi) reduces inflammatory breast cancer progression via protein synthesis inhibition (2011) (0)
- Abstract 181: Discovery of novel targeted therapeutics for metastatic breast cancer (2017) (0)
- Abstract 2142: Dietary grape polyphenol resveratrol regulates Rac activity to increase mammary tumor growth and metastasis (2012) (0)
- Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 (2022) (0)
- Abstract 3994: Anti-metastatic drug MBQ-167 regulates cell polarity via Cdc42 (2018) (0)
- Supercritical Fluid Chromatography‐Tandem Mass Spectrometry Method Development for the Detection of the Rac/Cdc42 inhibitor MBQ‐167 in Mouse Plasma (2017) (0)
- Abstract 2973: Rac inhibitors for cancer therapy (2022) (0)
- Abstract 1905: New targeted therapeutics for gastric cancer (2018) (0)
- Abstract 3076: Characterization of an improved derivative of the Rac/PAK inhibitor EHop-016 in breast cancer (2016) (0)
- Abstract 4390: Dietary soy isoflavone equol promotes breast cancer progression via regulation of protein synthesis initiation (2019) (0)
- Abstract 4185: The novel Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer (2018) (0)
- Bioanalytical Method Development for the Detection of the Rac/Cdc42 Inhibitor MBQ‐167 in Mouse Tissue (2019) (0)
- Prevention of inflammatory breast cancer by Reishi mushroom extract (2007) (0)
- Abstract P5-08-09: Characterization of the Rac/Cdc42 inhibitor MBQ-168 as an anti-cancer compound (2022) (0)
- Abstract 2246: Combined grape polyphenols regulate mammalian target of rapamycin (mTOR) signaling via a dual mechanism of Akt inhibition and AMPK activation (2012) (0)
- Abstract 17: MBQ-167, a Rac/Cdc42 targeted therapeutic, in combination with paclitaxel for TNBC treatment (2020) (0)
- Abstract 4018: Interaction site elucidation of the Rac1/Cdc42 inhibitor, MBQ-167 (2020) (0)
- Abstract 1987: Ganoderma lucidum (Reishi) suppresses key protein synthesis initiation molecules in inflammatory breast cancer (2012) (0)
- The Role of Non‐coding RNAs in Breast Cancer Resistance to EGFR Therapy (2015) (0)
- Award Number: W81XWH-07-1-0330 TITLE: Estrogen and the Dietary Phytoestrogen Tesveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research (2008) (0)
- Abstract 3020: Tumor pharmacokinetics of the metastatic cancer inhibitor MBQ-167 in mice (2020) (0)
- Regulation of the mammalian target of rapamycin signaling by grape polyphenols in breast cancer (766.6) (2014) (0)
- Increased protein synthesis of IRES containing mRNAs, that induce cell survival and proliferation, by the daidzein metabolite equol may contribute to breast cancer malignancy. (2013) (0)
- Characterization of Rac/Cdc42 Inhibitors as Anti‐cancer Compounds (2021) (0)
- Estrogen and the Dietary Phytoestrogen Tesveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research (2009) (0)
- Abstract 4868: Dietary resveratrol promotes breast cancer progression in immunocompromised mice. (2013) (0)
- Abstract A44: Establishment of patient-derived Hispanic gastric cancer xenografts to test targeted therapeutics (2018) (0)
- Validation of Cdc42 Inhibition as the Mechanism of Action of the Anti‐metastatic Drug MBQ‐167, Using Budding Yeast as a Model System (2018) (0)
- Abstract 2483: Rac and Cdc42 Inhibitors in Rheumatoid Arthritis Therapy (2023) (0)
- Rac and Cdc42 Inhibitors in Rheumatoid Arthritis Therapy (2022) (0)
- Abstract 1998: Characterization of immunoliposomes for HER2-targeted delivery of the dual Rac/Cdc42 inhibitor MBQ-167 (2023) (0)
- Abstract P6-21-14: Targeting Rac/Cdc42 in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (2019) (0)
- Abstract 4065: Efficacy of the Rac/Cdc42 inhibitor MBQ-167 in combination therapy with Paclitaxel (2022) (0)
- In Situ Evaluation of the Role of the Small GTPase Rac3 in Breast Cancer Metastasis (2004) (0)
- Abstract 1997: The Rac inhibitors HV-107 and HV-118 as potential therapeutics for metastatic breast cancer (2019) (0)
- Equol increases cancer potential via c-Myc upregulation 1 Equol , an isoflavone metabolite , regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF 4 G (2014) (0)
- Overcoming Therapy Resistance in HER2‐positive Breast Cancer with the Dual Rac/Cdc42 Inhibitor MBQ‐167 (2021) (0)
- Determination of Rac inhibitor Ehop‐016 in mouse plasma by ultra‐performance liquid chromatography tandem mass spectrometry (987.2) (2014) (0)
- Award Number: W81XWH-07-1-0330 TITLE: Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Metastasis (2011) (0)
- Abstract 4390: Non-coding RNAs in EGFR therapy resistance in breast cancer (2014) (0)
- Abstract B011: Rac and Cdc42 inhibition in the tumor microenvironment as a strategy to prevent metastasis (2023) (0)
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Suranganie Dharmawardhane is affiliated with the following schools:
