Suresh H. Moolgavkar

Suresh H. Moolgavkar's AcademicInfluence.com Rankings

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#2610

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#3041

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Epidemiology

#482

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#504

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Suresh H. Moolgavkar

Mathematics

#6717

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#9254

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Statistics

#672

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#757

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Measure Theory

#1542

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#1916

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mathematics Degrees

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Why Is Suresh H. Moolgavkar Influential?

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According to Wikipedia, Suresh H. Moolgavkar is an Indian mathematician and epidemiologist who was at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. He is a Senior Fellow and Research Scientist at Exponent, a consulting firm. Among his many scientific contributions is the development of the two-stage clonal expansion model of carcinogenesis, also known as the Moolgavkar-Venzon-Knudson model, a stochastic cell-level description of carcinogenesis based on Alfred G. Knudson’s two-hit hypothesis. In its original development the TSCE model represents tumor initiation as the first hit, followed by cell proliferation and malignant transformation as the second hit. It has been interpreted as describing the initiation-promotion-progression sequence observed in chemical carcinogenesis and has been applied widely for the analysis of both experimental and epidemiological data for purposes of quantitative risk assessment.

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Suresh H. Moolgavkar's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mutation and cancer: a model for human carcinogenesis. (1981) (1048)
A Method for Computing Profile-Likelihood- Based Confidence Intervals (1988) (534)
Two-event models for carcinogenesis: incidence curves for childhood and adult tumors☆ (1979) (493)
Multistage carcinogenesis and the incidence of colorectal cancer (2002) (349)
Two-stage model for carcinogenesis: Epidemiology of breast cancer in females. (1980) (296)
Two-event model for carcinogenesis: biological, mathematical, and statistical considerations. (1990) (277)
Tobacco control and the reduction in smoking-related premature deaths in the United States, 1964-2012. (2014) (255)
A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor. (1988) (241)
Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973–2005 (2009) (173)
Evidence of Health Impacts of Sulfate-and Nitrate-Containing Particles in Ambient Air (2007) (167)
The multistage theory of carcinogenesis and the age distribution of cancer in man. (1978) (165)
Some Properties of the Hazard Function of the Two‐Mutation Clonal Expansion Model (1997) (164)
Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000 (2012) (161)
Age-specific incidence of cancer: Phases, transitions, and biological implications (2008) (160)
Air Pollution and Daily Mortality in Philadelphia (1995) (153)
A critical review of the evidence on particulate air pollution and mortality. (1996) (152)
Multistage carcinogenesis: population-based model for colon cancer. (1992) (150)
Particulate air pollution and mortality. (1996) (147)
Carcinogenesis modeling: from molecular biology to epidemiology. (1986) (146)
Radon, Cigarette Smoke, and Lung Cancer: A Re‐analysis of the Colorado Plateau Uranium Miners' Data (1993) (143)
Biologically based analysis of the data for the Colorado uranium miners cohort: age, dose and dose-rate effects. (1999) (130)
Air Pollution and Hospital Admissions for Respiratory Causes in Minneapolis‐St. Paul and Birmingham (1997) (120)
Quantitative analysis of enzyme-altered foci in rat hepatocarcinogenesis experiments--I. Single agent regimen. (1990) (116)
Multistage Carcinogenesis and Lung Cancer Mortality in Three Cohorts (2005) (114)
A two-mutation model for radon-induced lung tumors in rats. (1990) (113)
A stochastic two-stage model for cancer risk assessment. II. The number and size of premalignant clones. (1989) (113)
Effect of age on incidence of breast cancer in females. (1979) (112)
Air pollution and daily mortality in three U.S. counties. (2000) (106)
Cancer models. (1990) (103)
Air Pollution and Hospital Admissions for Diseases of the Circulatory System in Three U.S. Metropolitan Areas (2000) (101)
Analysis of the incidence of solid cancer among atomic bomb survivors using a two-stage model of carcinogenesis. (1997) (100)
Analysis of a Historical Cohort of Chinese Tin Miners with Arsenic, Radon, Cigarette Smoke, and Pipe Smoke Exposures Using the Biologically Based Two-Stage Clonal Expansion Model (2001) (96)
Analysis of lung cancer incidence in the nurses’ health and the health professionals’ follow-up studies using a multistage carcinogenesis model (2008) (94)
Cigarette smoking and lung cancer: reanalysis of the British doctors' data. (1989) (93)
Model for human carcinogenesis: action of environmental agents. (1983) (92)
Multistage carcinogenesis and the incidence of human cancer (2003) (88)
Modern Statistical Methods in Chronic Disease Epidemiology. (1988) (81)
Chapter 6: Lung Cancer in Never Smokers: Epidemiology and Risk Prediction Models (2012) (75)
Quantitative analysis of tumor initiation in rat liver: role of cell replication and cell death (apoptosis). (2000) (73)
Air pollution and hospital admissions for chronic obstructive pulmonary disease in three metropolitan areas in the United States. (2000) (73)
Two-stage model of radon-induced malignant lung tumors in rats: effects of cell killing. (1996) (71)
Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. (1996) (69)
Lung cancer rate predictions using generalized additive models. (2005) (68)
A generalized Luria-Delbrück model. (2005) (68)
Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions (2008) (63)
Age effects and temporal trends in adenocarcinoma of the esophagus and gastric cardia (United States) (2006) (63)
Effects of polychlorinated biphenyls in rat liver: quantitative analysis of enzyme-altered foci. (1991) (62)
General relative risk regression models for epidemiologic studies. (1987) (62)
Two-mutation model for carcinogenesis: joint analysis of premalignant and malignant lesions. (1991) (60)
Particulate Air Pollution, Sulfur Dioxide, and Daily Mortality: A Reanalysis of the Steubenville Data (1995) (59)
Confidence Regions in Curved Exponential Families: Application to Matched Case-Control and Survival Studies with General Relative Risk Function (1987) (57)
Stochastic analysis of intermediate lesions in carcinogenesis experiments. (1991) (55)
A cohort analysis of lung cancer and smoking in British males. (1984) (53)
Cohort analysis of malignant melanoma in five countries. (1984) (51)
Systems biological and mechanistic modelling of radiation-induced cancer (2007) (51)
Multistage Models and the Incidence of Cancer in the Cohort of Atomic Bomb Survivors (2002) (50)
Comparing Benefits from Many Possible Computed Tomography Lung Cancer Screening Programs: Extrapolating from the National Lung Screening Trial Using Comparative Modeling (2014) (49)
Smoking and cancers of bladder and pancreas: risks and temporal trends. (1981) (48)
Temporal trends in breast cancer. (1982) (47)
Biopersistence, fiber length, and cancer risk assessment for inhaled fibers. (2001) (47)
A biologically-based dose-response model for developmental toxicology. (1996) (44)
Air Pollution and Daily Mortality in Two U.S. Counties: Season-Specific Analyses and Exposure-Response Relationships (2003) (43)
Diesel Emissions and Lung Cancer : Epidemiology and Quantitative Risk Assessment (1999) (41)
Time-Series Analyses of Air Pollution and Mortality in the United States: A Subsampling Approach (2012) (41)
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on initiation and promotion of GST-P-positive foci in rat liver: A quantitative analysis of experimental data using a stochastic model. (2000) (41)
Quantitative Estimation and Prediction of Human Cancer Risks (1999) (39)
Quantitative Assessment of the Risk of Lung Cancer Associated with Occupational Exposure to Refractory Ceramic Fibers (1999) (37)
Biologically Based Analysis of Lung Cancer Incidence in a Large Canadian Occupational Cohort with Low-Dose Ionizing Radiation Exposure, and Comparison with Japanese Atomic Bomb Survivors (2006) (37)
Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach. (2008) (36)
Epidemiology of mesothelioma of the pericardium and tunica vaginalis testis. (2017) (35)
A review and critique of the EPA's rationale for a fine particle standard. (2005) (35)
Critical considerations in evaluating scientific evidence of health effects of ambient ozone: a conference report (2009) (35)
Comparison of age-specific mortality from breast cancer in males in the United States and Japan. (1978) (34)
LUNG CANCER RISK ASSOCIATED WITH EXPOSURE TO MAN-MADE FIBERS (2000) (34)
Biologically motivated two-stage model for cancer risk assessment. (1988) (34)
Allelic instability in mitosis: a unified model for dominant disorders. (1993) (34)
Gestational mutations and carcinogenesis. (2005) (34)
An Assessment of the Cox Proportional Hazards Regression Model for Epidemiologic Studies (2018) (34)
Modeling epidemiologic studies of occupational cohorts for the quantitative assessment of carcinogenic hazards. (1995) (33)
Growth kinetics of enzyme-altered liver foci in rats treated with phenobarbital or alpha-hexachlorocyclohexane. (1995) (32)
A Geometric Approach to Nonlinear Regression Diagnostics with Applications to matched Case-Control Studies (1984) (32)
Estimation of Unit Risk for Coke Oven Emissions (1998) (30)
Malignant melanoma: dependence of site-specific risk on age. (1984) (30)
Scientific Issues in Quantitative Cancer Risk Assessment (1990) (30)
Diesel Engine Exhaust and Lung Cancer Mortality: Time‐Related Factors in Exposure and Risk (2015) (29)
Interpretation of labeling indices in the presence of cell death. (1992) (29)
Mechanisms of carcinogenesis and biologically based models for estimation and prediction of risk. (1999) (28)
Commentary: Fifty years of the multistage model: remarks on a landmark paper. (2004) (28)
Carcinogenesis models: an overview. (1991) (28)
Validity of geographically modeled environmental exposure estimates (2014) (27)
Nulliparity, decade of first birth, and breast cancer in Connecticut cohorts, 1855 to 1945: an ecological study. (1989) (26)
Long man-made fibers and lung cancer risk. (2001) (25)
Estimation of relative risk from vital data: smoking and cancers of the lung and bladder. (1979) (25)
Assessing the adequacy of the logistic regression model for matched case-control studies. (1985) (24)
Cell proliferation and carcinogenesis models: general principles with illustrations from the rodent liver system. (1993) (23)
Biologically based models for cancer risk assessment: a cautionary note. (1988) (23)
Role of receptors in human and rodent hepatocarcinogenesis. (1995) (23)
A systematic review of occupational exposure to synthetic vitreous fibers and mesothelioma (2014) (22)
The role of promotion in carcinogenesis from protracted high-LET exposure. (2001) (22)
Two stage model for carcinogenesis: number and size distributions of premalignant clones in longitudinal studies. (1999) (22)
Reanalysis of the DEMS Nested Case-Control Study of Lung Cancer and Diesel Exhaust: Suitability for Quantitative Risk Assessment (2015) (22)
[31] Δ 5-3-ketosteroid isomerase of pseudomonas testosteroni (1969) (22)
Potency Factors for Risk Assessment at Libby, Montana (2010) (21)
Biological models of carcinogenesis and quantitative cancer risk assessment. (1994) (21)
Effects of Exposure Uncertainties in the TSCE Model and Application to the Colorado Miners Data (2004) (20)
No association between oral contraceptives and malignant melanomas. (1980) (20)
A Diagnostic Statistic for the Score Test (1985) (19)
Hormones and multistage carcinogenesis. (1986) (19)
Incorporating cell proliferation kinetics into models for cancer risk assessment. (1995) (18)
A 37-year Update on Mortality Patterns in an Expanded Cohort of Vermont Talc Miners and Millers. (2019) (18)
Chapter 8: The FHCRC Lung Cancer Model (2012) (17)
A review and critique of U.S. EPA's risk assessments for asbestos (2014) (17)
Simulating the process of malignant transformation. (1994) (17)
Modulation of liver tumorigenesis in Connexin32-deficient mouse. (2005) (16)
The use of biologically based cancer risk models in radiation epidemiology. (2003) (16)
Biologically based cancer modeling. (1996) (16)
From mechanisms to risk estimation--bridging the chasm. (2004) (16)
Stable parallelizability of lens spaces (1977) (15)
A Poisson process approach for recurrent event data with environmental covariates. (2000) (15)
Testing goodness of fit for stochastic models of carcinogenesis. (2002) (14)
A new perspective of carcinogenesis from protracted high-LET radiation arises from the two-stage clonal expansion model. (2002) (14)
Fine Particles and Mortality (2006) (13)
Myeloid leukaemia following therapy for a first primary cancer. (1991) (12)
Biostatistical issues and concepts in epidemiologic research. (1986) (12)
Cancer mortality and quantitative oil production in the Amazon region of Ecuador, 1990–2010 (2013) (12)
Chapter 15: Impact of Tobacco Control on Lung Cancer Mortality in the United States Over the Period 1975–2000—Summary and Limitations (2012) (11)
Tests of the null hypothesis in case-control studies. (1984) (11)
Smoking, air pollution, and lung cancer risk in the Nurses’ Health Study cohort: time-dependent confounding and effect modification (2020) (10)
Reanalysis of Diesel Engine Exhaust and Lung Cancer Mortality in the Diesel Exhaust in Miners Study Cohort Using Alternative Exposure Estimates and Radon Adjustment (2018) (10)
The power of the European Union protocol to test for carcinogenicity of inhaled fibers. (2001) (10)
12 Stochastic models of carcinogenesis (1991) (9)
Two Mutation Model for Carcinogenesis: Relative Roles of Somatic Mutations and Cell Proliferation in Determining Risk (1990) (9)
Confidence regions for parameters of the proportional hazards model: a simulation study (1987) (9)
Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers. (2012) (9)
Origin-invariant relative risk functions for case-control and survival studies (1988) (8)
Epidemiology of Mesothelioma (2017) (8)
Multistage Models for Cancer Risk Assessment (1989) (8)
Euler characteristics of complete intersections (1976) (8)
The multistage theory of carcinogenesis (1977) (7)
A biologically based model for the analysis of premalignant foci of arbitrary shape. (1996) (7)
Commentary: Multistage carcinogenesis and epidemiological studies of cancer. (2016) (7)
Comments to the SAB on the EPA document EPA/635/R-002A, “Draft Toxicological Review of Libby Amphibole Asbestos” (2012) (7)
Choice of stratification in Poisson process analysis of recurrent event data with environmental covariates (2002) (7)
What Is the Scope of the Journal Risk Analysis (2008) (6)
Pollution analysis flawed by statistical model (2007) (6)
Smoking and Cancers of Bladder and Pancreas: Risks and Temporal Trends (1982) (6)
Chronic Effects of Air Pollution are Probably Overestimated (2015) (6)
Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis (2020) (6)
Recent bioassay results on coal tars and benzo(a)pyrene: implications for risk assessment. (1998) (6)
Re: "Bayesian projections: what are the effects of excluding data from younger age groups?". (2006) (5)
Air Pollution, Pollens, and Admissions for Chronic Respiratory Disease in King County, Washington (2000) (5)
Stochastic cancer models : application to analyses of solid cancer incidence in the cohort of A-bomb survivors : Health effects of low dose radiation (1997) (5)
Future perspectives, unresolved issues and research needs. (1999) (5)
A two-stage carcinogenesis model for risk assessment (1989) (5)
The importance of promotion in lung carcinogenesis for protracted exposures to radon and radon progeny. (2000) (5)
Letter to the Editor: Egilman et. al.'s Misrepresentation of the Fordyce et al. (2019) Vermont Talc Miners and Millers Cohort Study Update. (2019) (5)
Fine Particulate Matter Pollution and Mortality (2016) (5)
On the number of founding germ cells in humans (2005) (5)
Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens (2010) (4)
Review of specific examples of QEP. (1999) (4)
Some problems of inference in cohort studies. (1987) (4)
Principles of the epidemiological approach to QEP. (1999) (4)
Commentary: Frailty and heterogeneity in epidemiological studies. (2015) (4)
Comments on Vimercati et al., 2019, “Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register” (2019) (3)
Multistage models and the A-bomb survivor data: implications for carcinogenic mechanisms? (2000) (3)
A population perspective on multistage carcinogenesis. (1991) (3)
Air pollution and mortality. (1994) (3)
Multistage models for carcinogenesis. (1980) (3)
Analysis of Breast Cancer Incidence Among Atomic Bomb Survivors Using a Two-Stage Model of Carcinogenesis (1997) (3)
Commentary: Multistage carcinogenesis and epidemiological studies of cancer. (2017) (3)
Risk assessment of non-genotoxic carcinogens. (1992) (3)
American Mathematics from 1940 to the Day Before Yesterday (1976) (2)
Comments on papers on U-shaped dose-response relationships for carcinogens (1998) (2)
Does radiation enhance promotion of already-initiated cells in protracted high-LET carcinogenesis via a bystander effect? (2002) (2)
Response to the Commentary of Donald A. Pierce (Radiat. Res. 160, 718–723, 2003) (2004) (2)
Consideration of Copollutants (2000) (2)
Multistage Carcinogenesis: A Unified Framework for Cancer Data Analysis (2020) (2)
On the signature of Fermat surfaces. (1976) (1)
Stochastic description of initiation and promotion in experimental carcinogenesis. (1991) (1)
The Neyman-Scott carcinogenesis model for low-dosage extrapolation (1980) (1)
The role of somatic mutations and cell replication kinetics in quantitative cancer risk assessment. (1991) (1)
Potential funding crisis for the Radiation Effects Research Foundation (2004) (1)
RE: "DIESEL EXHAUST AND LUNG CANCER-AFTERMATH OF BECOMING AN IARC GROUP 1 CARCINOGEN". (2018) (1)
Biologically Based Cancer Risk Assessment Models (2001) (1)
Re: "Combined effect of childbearing, menstrual events, and body size on age-specific breast cancer risk". (1988) (1)
Biological and Mathematical Aspects of Multistage Carcinogenesis (2006) (1)
Experiments with radon and cigarette smoke (1993) (1)
Carcinogenesis models. (1991) (0)
Two-Mutation Carcinogenesis Model† (2014) (0)
Funding crisis at the Radiation Effects Research Foundation (2004) (0)
Gestational Mutations and Carcinogenesis (2011) (0)
Cancer mortality and quantitative oil production in the Amazon region of Ecuador, 1990–2010 (2013) (0)
Mechanisms and shapes of causal exposure-response functions for asbestos in mesotheliomas and lung cancers. (2023) (0)
Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma. (2022) (0)
[Experiments with radon and cigarette smoke]. Progress report (1993) (0)
Response to Dr. Wagner's Letter (2004) (0)
On the existence of a universal germ of deformations for elliptic pseudogroup structures on compact manifolds (1975) (0)
Two-Stage Model for Breast Carcinogenesis in Females: Reply (1981) (0)
Dose–Response Assessment — Quantitative Methods for the Investigation of Dose–Response Relationships (2019) (0)
Mutations and Carcinogenesis (2010) (0)
Response to the Letter of Dr. Sherman and Correction of Error in Radiat. Res. 148, 348-358 (1997) (1998) (0)
Smoking: Lung and Bladder Cancer: Reply (1980) (0)
[From Mouse-to-Man: The Quantitative Assessment of Cancer Risks]: Comment (1988) (0)
BOOK REVIEW: Wings of Death: Nuclear Pollution and Human Health. Chris Busby, Green Audit Books, Aberystwyth, Wales, 1995. No. of pages: ix+340. Price: £10.99. ISBN 1‐897761‐03‐1 (1997) (0)
Dose‚ÄìResponse Assessment ‚Äî Quantitative Methods for the Investigation of Dose‚ÄìResponse Relationships (1998) (0)
Letter to the Editor: Response to Finkelstein Re: . (2020) (0)
COMMENT ON: THE HAZARD FUNCTION OF A TWO-STAGE CARCINOGENESIS MODEL. AUTHORS' REPLY (1999) (0)
Response to Finkelstein Re: the Fordyce et al. Vermont Talc Miners and Millers Cohort Study Update. (2020) (0)
COMMENTS ON PANEL RECOMMENDATIONS TO EPA REGARDING THE DRAFT RISK ASSESSMENT OF LIBBY AMPHIBOLE ASBESTOS – JULY 2012 (2012) (0)
Modern statistical methods in chronic disease epidemiology : proceedings of a conference (1986) (0)
Analysis of radiation effects using a combined cell cycle and multistage carcinogenesis model (2006) (0)
Biologically based multistage modeling of radiation effects (2005) (0)
Pharmacodynamic Models for Cancer Risk Assessment (1992) (0)
Consideration of copollutants. (2000) (0)
Two-Mutation Carcinogenesis Model (2005) (0)
Biostatistics in cancer risk assessment. David G. Hoel and Takashi Yanagawa (eds), Scientist, Inc., Tokyo, 1991. No. of pages: 176. price: $30 (1994) (0)
Response to the Comments of Dr. Zheng (1999) (0)
Age and breast cancer incidence. (1984) (0)

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