Susan Band Horwitz
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Chemistry Biology
Susan Band Horwitz's Degrees
- PhD Biochemistry Brandeis University
- Bachelors Chemistry Brooklyn College
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(Suggest an Edit or Addition)Susan Band Horwitz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Promotion of microtubule assembly in vitro by taxol (1979) (3359)
- Taxol stabilizes microtubules in mouse fibroblast cells. (1980) (1902)
- Mechanism of action of taxol. (1992) (703)
- Mechanisms of Taxol resistance related to microtubules (2003) (691)
- Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol. (1991) (689)
- Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. (1997) (600)
- Taxol: an antimitotic agent with a new mechanism of action. (1984) (464)
- Taxol (paclitaxel): mechanisms of action. (1994) (422)
- Mechanisms of Taxol-induced cell death are concentration dependent. (1998) (418)
- Taxol binds to cellular microtubules (1982) (417)
- Taxol: Mechanisms of Action and Resistance a (1986) (394)
- Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. (1981) (360)
- Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins. (1981) (358)
- Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. (1978) (344)
- Properties and products of the degradation of DNA by bleomycin and iron(II). (1978) (302)
- Insights into the mechanism of microtubule stabilization by Taxol (2006) (286)
- Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus. (1989) (283)
- A role for ferrous ion and oxygen in the degradation of DNA by bleomycin. (1976) (265)
- The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. (1988) (258)
- Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics (2001) (256)
- 3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin. (1994) (237)
- A common pharmacophore for cytotoxic natural products that stabilize microtubules. (1999) (219)
- Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells. (2001) (219)
- Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. (1989) (218)
- Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. (2002) (213)
- Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells. (1976) (206)
- Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies. (1977) (200)
- The role of β-tubulin isotypes in resistance to antimitotic drugs (2001) (195)
- Characterization of the Taxol Binding Site on the Microtubule (1999) (190)
- Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol (1999) (186)
- Characterization of the Taxol Binding Site on the Microtubule (1995) (182)
- Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells. (1976) (178)
- Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. (2001) (172)
- Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. (2003) (168)
- Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. (2000) (160)
- A phosphoglycoprotein associated with taxol resistance in J774.2 cells. (1985) (158)
- Biologically active taxol analogues with deleted A-ring side chain substituents and variable C-2' configurations. (1991) (156)
- Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors (2004) (155)
- Effects of camptothecin on the breakage and repair of DNA during the cell cycle. (1973) (155)
- Direct photoaffinity labeling of tubulin with taxol. (1992) (154)
- Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells (1998) (149)
- Mechanism of bleomycin action: in vitro studies. (1981) (144)
- Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners. (1978) (143)
- Gene expression and mitotic exit induced by microtubule-stabilizing drugs. (2003) (142)
- Taxol®: The First Microtubule Stabilizing Agent (2017) (140)
- Studies on camptothecin. I. Effects of nucleic acid and protein synthesis. (1971) (140)
- The Microtubule-destabilizing Activity of Metablastin (p19) Is Controlled by Phosphorylation* (1997) (136)
- Altered Expression of M2, the Class II -Tubulin Isotype, in a Murine J774.2 Cell Line with a High Level of Taxol Resistance (*) (1995) (135)
- Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones (1997) (134)
- Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells (1990) (132)
- Novel molecules that interact with microtubules and have functional activity similar to Taxol. (2001) (131)
- Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin. (1980) (125)
- Phosphorylation of the multidrug resistance associated glycoprotein. (1987) (120)
- A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain. (2000) (118)
- MUTATIONS IN BETATUBULIN MAP TO DOMAINS INVOLVED IN REGULATION OF MICROTUBULE STABILITY IN EPOTHILONE-RESISTANT CELL LINES (2001) (117)
- Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis. (1976) (117)
- REMOTE EFFECTS IN MACROLIDE FORMATION THROUGH RING-FORMING OLEFIN METATHESIS : AN APPLICATION TO THE SYNTHESIS OF FULLY ACTIVE EPOTHILONE CONGENERS (1997) (112)
- Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. (2001) (112)
- Taxol: mechanisms of action and resistance. (1986) (109)
- The Microtubule Stabilizing Agent Discodermolide is a Potent Inducer of Accelerated Cell Senescence (2005) (105)
- The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells. (2001) (104)
- Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin. (1971) (102)
- Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly. (1979) (101)
- Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi. (1981) (99)
- Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity. (1994) (99)
- Structure–Activity Relationship of the Epothilones and the First In Vivo Comparison with Paclitaxel† (1997) (98)
- Differential transport properties of two mdr gene products are distinguished by progesterone. (1990) (98)
- Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes. (1982) (97)
- Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry. (2003) (97)
- Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells (2004) (96)
- Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. (1988) (96)
- Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity. (1979) (96)
- Microtubule arrays in taxol-treated mouse dorsal root ganglion-spinal cord cultures (1981) (95)
- Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus (1990) (94)
- Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins. (1987) (94)
- Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b. (1991) (93)
- Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. (2005) (93)
- P‐glycoprotein transports corticosterone and is photoaffinity‐labeled by the steroid (1992) (92)
- Taxol-induced neuropathy: short-term effects of local injection (1984) (91)
- Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein. (1990) (89)
- Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study. (2002) (88)
- Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer (2010) (86)
- Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes (2016) (85)
- Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. (2007) (84)
- Nature as a remarkable chemist: a personal story of the discovery and development of Taxol (2014) (84)
- Design, synthesis, and biological evaluation of new-generation taxoids. (2008) (82)
- Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins. (1988) (82)
- Preparation and biological activity of taxol acetates. (1984) (81)
- Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. (1987) (81)
- Taxol: a new probe for studying the structure and function of microtubules. (1982) (78)
- Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490. (2002) (77)
- Morphological alterations in dorsal root ganglion neurons and supporting cells of organotypic mouse spinal cord-ganglion cultures exposed to taxol (1983) (77)
- Mössbauer study of iron bleomycin and its activation intermediates. (1983) (76)
- Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle checkpoint, Leading to Aneuploidy (2005) (75)
- Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-Bearing Mice (2006) (72)
- Progesterone regulates the murine multidrug resistance mdr1b gene. (1993) (72)
- Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents (2005) (70)
- The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. (2001) (69)
- Tubulin proteomics: towards breaking the code. (2009) (68)
- Characterization of the association of radiolabeled bleomycin A2 with HeLa cells. (1984) (64)
- Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. (2005) (63)
- Stoichiometry of DNA strand scission and aldehyde formation by bleomycin. (1982) (62)
- The effect of aphidicolin on adenovirus DNA synthesis. (1979) (61)
- Hallmarks of Molecular Action of Microtubule Stabilizing Agents (2011) (60)
- A highly epothilone B–resistant A549 cell line with mutations in tubulin that confer drug dependence (2005) (59)
- HEXITOL DEHYDROGENASES OF BACILLUS SUBTILIS. (1964) (56)
- How to make taxol from scratch (1994) (56)
- Personal recollections on the early development of taxol. (2004) (56)
- The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release. (1986) (56)
- Oxygenated iron bleomycin. A short-lived intermediate in the reaction of ferrous bleomycin with O2. (1979) (56)
- Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. (1993) (55)
- Taxol mediates serine phosphorylation of the 66-kDa Shc isoform. (2000) (54)
- Taxol induces tyrosine phosphorylation of SHC and its association with GRB2 in murine raw 264.7 cells (1997) (54)
- Taxol in ovarian cancer (1993) (54)
- D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes. (1962) (53)
- Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line (1981) (53)
- Identification of the in Vivo Phosphorylation Sites for Acidic-directed Kinases in Murine mdr1b P-glycoprotein* (1997) (53)
- Structural and functional analysis of the mouse mdr1b gene promoter. (1991) (53)
- Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis. (1976) (50)
- Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein. (1998) (49)
- Effects of O2 on the reactions of activated bleomycin. (1982) (49)
- Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines. (2001) (48)
- Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells. (1988) (48)
- Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene. (1993) (46)
- Bleomycin, an inhibitor of vaccinia virus replication. (1974) (45)
- Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. (2009) (43)
- A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin. (2006) (41)
- Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry. (2003) (41)
- A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein. (1995) (41)
- Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics. (2005) (39)
- Reduction of copper(II)-bleomycin: a model for in vivo drug activity. (1982) (38)
- Coordination of transcription factors, NF-Y and C/EBP beta, in the regulation of the mdr1b promoter. (1995) (38)
- Effect of ATP and other nucleotides on the bleomycin-induced degradation of vaccinia virus DNA. (1976) (37)
- Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties (1997) (37)
- Triphenylmethane dyes as inhibitors of reverse transcriptase, ribonucleic acid polymerase, and protein synthesis. Structure-activity relationships. (1975) (36)
- Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. (2005) (35)
- Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines (1999) (35)
- Redox potential of iron-bleomycin. (1981) (34)
- Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells. (2002) (34)
- Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence (2011) (34)
- High expression of class III β-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancer. (2013) (32)
- Effect of light and oxygen on neocarzinostatin stability and DNA-cleaving activity. (1978) (32)
- Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine. (2008) (32)
- Demonstration of nitrogen coordination in metal--bleomycin complexes by electron spin--echo envelope spectroscopy. (1981) (31)
- DNA degradation by manganese(II)-bleomycin plus peroxide (1984) (30)
- Chemical synthesis of radiolabeled bleomycin A2 and its binding to DNA. (1981) (30)
- A comparison of the mechanisms of action of VP-16-213 and podophyllotoxin. (1977) (29)
- Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4. (2012) (29)
- Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro. (1978) (29)
- The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development (2008) (29)
- Stathmin/Op18 is a novel mediator of vinblastine activity (2008) (28)
- Alternate overexpression of two P-glycoprotein [corrected] genes is associated with changes in multidrug resistance in a J774.2 cell line. (1989) (28)
- Effect of alkaline pH on taxol-microtubule interactions. (1991) (27)
- Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells. (1992) (27)
- Wild-type class I β-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a β-tubulin mutation (2007) (27)
- Stimulation of iron(II) bleomycin activity by phosphate-containing compounds. (1985) (27)
- The redox state of activated bleomycin. (1985) (26)
- Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity. (2011) (26)
- Taxol induces the formation of unusual arrays of cellular microtubules in colchicine-pretreated J774.2 cells. (1986) (26)
- Exploiting MEK Inhibitor-Mediated Activation of ERα for Therapeutic Intervention in ER-Positive Ovarian Carcinoma (2013) (26)
- Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide. (2005) (26)
- Use of antibodies to probe membrane glycoproteins associated with drug-resistant J774.2 cells. (1987) (26)
- Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer. (2008) (26)
- Modulation of the function of P-glycoprotein by estramustine. (1994) (25)
- Functional expression of murine multidrug resistance in Xenopus laevis oocytes. (1990) (25)
- Structural Basis of Microtubule Stabilization by Discodermolide (2017) (25)
- The products of the mdr1a and mdr1b genes from multidrug resistant murine cells have similar degradation rates. (1990) (25)
- Antiviral Action of Camptothecin (1972) (24)
- The involvement of a LINE-1 element in a DNA rearrangement upstream of the mdr1a gene in a taxol multidrug-resistant murine cell line. (1992) (24)
- Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. (2009) (24)
- Analysis of MDR1 expression in normal and malignant endometrium by reverse transcription-polymerase chain reaction and immunohistochemistry. (1996) (24)
- Synthesis and Biological Evaluation of Novel 3'-Difluorovinyl Taxoids. (2012) (24)
- Chemosterilant Action of Anthramycin: A Proposed Mechanism (1971) (23)
- Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1–dependent (2010) (23)
- Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules. (1993) (22)
- Expression of phenotypic traits following modulation of colchicine resistance in J774.2 cells (1986) (22)
- 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes (2016) (22)
- Methods in tubulin proteomics. (2010) (22)
- TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas. (2015) (21)
- Proteomics of Cancer Cell Lines Resistant to Microtubule-Stabilizing Agents (2013) (21)
- Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes. (2005) (20)
- Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation. (2007) (20)
- Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids. (2008) (19)
- On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. (2000) (19)
- Taxol induced microtubule formations in fibroblasts of fetal mouse dorsal root ganglion-spinal cord cultures (1982) (19)
- Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone. (2007) (18)
- Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. (2018) (18)
- Taxol binds differentially to flagellar outer doublets and their reassembled microtubules. (1983) (18)
- Mutations in -Tubulin Map to Domains Involved in Regulation of Microtubule Stability in Epothilone- resistant Cell Lines (2001) (18)
- Characterization of two taxol photoaffinity analogues bearing azide and benzophenone-related photoreactive substituents in the A-ring side chain. (1994) (17)
- Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. (2010) (16)
- P‐glycoproteins encoded by mdr 1b in murine gravid uterus and multidrug resistant tumor cell lines are differentially glycosylated (1989) (15)
- Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate (2004) (14)
- Identification of two nuclear protein binding sites and their role in the regulation of the murine multidrug resistance mdr1a promoter. (1994) (14)
- The synthesis and evaluation of 12,13-benzodesoxyepothilone B: A highly convergent route (1999) (14)
- Vinblastine paracrystals from cultured cells are calcium-stable. (1984) (14)
- Coordination of Transcription Factors, NFY and C/EBP, in the Regulation of the mdrl b Promoter' (1995) (13)
- The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells (2010) (13)
- A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis. (1995) (13)
- Transcriptional regulation of the murine multidrug resistance gene mdr1b by progesterone occurs via an indirect mechanism. (1997) (13)
- Gallin (9-(2'-carboxyphenyl)-3,4,5,6-tetrahydroxyxanthene), a new inhibitor of Escherichia coli ribonucleic acid polymerase. (1974) (12)
- Probenecid-resistant J774 cell expression of enhanced organic anion transport by a mechanism distinct from multidrug resistance. (1993) (12)
- Alternate Overexpression of Two Phosphoglycoprotein Genes Is Associated with Changes in Multidrug Resistance in a J774.2 Cell Line (1989) (12)
- Characterization of a human βV‐tubulin antibody and expression of this isotype in normal and malignant human tissue (2012) (12)
- MECHANISM OF THE ANTIVIRAL ACTION OF BLEOMYCIN (1977) (12)
- Posttranslational Modifications of Tubulin (2012) (12)
- Development of two radioimmunoassays to detect paclitaxel in sera and in cerebrospinal, ascitic, and pleural fluids (1997) (12)
- Eribulin disrupts EB1-microtubule plus-tip complex formation (2014) (12)
- Analogs of camptothecin. (1975) (11)
- Remote Effects in Macrolide Formation Through Ring-Forming Olefin Metathesis: An Application to the Synthesis of Fully Active Epothilone Congeners. (1997) (11)
- Interactions of small molecules with nucleic acids. I. Mode of action of anthramycin. (1968) (10)
- The oxidation-reduction potential of copper-bleomycin (1987) (10)
- Germline mutations of the DNA repair pathways in uterine serous carcinoma. (2016) (10)
- In vitro models of multiple drug resistance. (1994) (10)
- Chemosterilization of house flies with anthramycin methyl ether. (1971) (10)
- Molecular/cytogenetic alterations accompanying the development of multidrug resistance in the J774.2 murine cell line. (1988) (9)
- Taxol effects on glia in organotypic mouse spinal cord-DRG cultures. (1985) (9)
- Synthesis of novel taxol analogs and evaluation of their biological activities (1997) (8)
- Diastereoisomers of formaldehyde derivatives of tetrahydrofolic acid and tetrahydroaminopterin. (1969) (8)
- Synthesis and biological activity in the camptothecin series (1973) (8)
- Immunoreactivity to antinucleoside antibodies in camptothecin treated HeLa cells. (1974) (8)
- Inhibition of SV40 DNA synthesis by camptothecin and neocarzinostatin. (1978) (8)
- Domain organization of murine mdr1b P-glycoprotein: the cytoplasmic linker region is a potential dimerization domain. (1997) (7)
- Photoaffinity labeling approach to map the Taxol-binding site on the microtubule. (1998) (7)
- Morphologic alterations in satellite and Schwann cells after exposure of fetal mouse dorsal root ganglia - spinal cord cultures to taxol (1981) (7)
- Advances in Brief Differential Mitotic Responses to Microtubule-stabilizing and-destabilizing Drugs 1 (2002) (7)
- Characterization of the taxol structure-activity profile for the locus of the A-ring side chain (1994) (7)
- Evidence for linear extrachromosomal elements mediating gene amplification in the multidrug-resistant J774.2 murine cell line. (1992) (6)
- Combined MEK and mTOR suppression is synergistic in human NSCLC and is mediated via inhibition of protein translation (2007) (6)
- Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism. (1969) (6)
- 15 – Multidrug Resistance in the Mouse Macrophage-Like Cell Line J774.2 (1988) (6)
- Reduced derivatives of methotrexate. (1968) (6)
- CONFORMATIONAL ANALYSIS OF PODOPHYLLOTOXIN AND ITS CONGENERS. STRUCTURE-ACTIVITY RELATIONSHIP IN MICROTUBULE ASSEMBLY (1979) (5)
- 646 POSTER Insights into the mechanism of microtubule stabilization by Taxol (2006) (4)
- A Role for Iron in the Degradation of DNA by Bleomycin (1979) (4)
- Down-regulation of the mdr gene by thyroid hormone during Xenopus laevis development (1997) (4)
- Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence (2020) (4)
- [31] d-Mannitol 1-phosphate dehydrogenase and d-sorbitol dehydrogenase from Bacillus subtilis (1966) (4)
- Concentric arrays of ordered microtubules alternating with macromolecular layers in neurites of taxol-treated cultures of mouse dorsal root ganglion and spinal cord (1981) (3)
- Ultrastructural effects of colchicine, vinblastine, and taxol in drug-sensitive and multidrug-resistant J 774.2 cells (1989) (3)
- TRIPHENYLMETHANE DYES AS INHIBITORS OF REVERSE TRANSCRIPTASE, RIBONUCLEIC ACID POLYMERASE, AND PROTEIN SYNTHESIS, STRUCTURE‐ACTIVITY RELATIONSHIPS (1975) (3)
- Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners. (2018) (3)
- Abstract B165: The antitumor efficacy of eribulin is mediated via suppression of invasion and profound induction of cell death in triple negative breast cancer. (2013) (3)
- Reflections on My Life with Taxol (2019) (3)
- Protein pathway activation mapping guided biomarker development to identify optimal combinations of MEK inhibitor with PI3K/mTOR pathway inhibitors for the treatment of triple-negative breast cancer. (2013) (2)
- Oxygenated Iron Bleomycin (2002) (2)
- Identification of in vivo phosphorylation sites for basic-directed kinases in murine mdr1b P-glycoprotein by combination of mass spectrometry and site-directed mutagenesis. (1998) (2)
- A conversation with Susan Band Horwitz. (2015) (2)
- Discodermolide and Taxol: A Synergistic Drug Combination in Human Carcinoma Cell Lines (2001) (2)
- Expression of βV-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia (2017) (2)
- Erratum: Alternate overexpression of two P-glycoprotein genes is associated with changes in multidrug resistance in a J774.2 cell line (Vol. 264 (1989) 16054-16058) (1990) (2)
- Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells (1990) (2)
- Taxol-induced microtubule arrays in mouse dorsal root ganglion-spinal cord cultures (1980) (2)
- The microtubule stabilizing agent discodermolide is also a powerful inducer of accelerated senescence (2004) (2)
- Vinca alkaloids. (1991) (2)
- Microtubule Stabilizing Agents (2008) (2)
- Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents (2007) (2)
- Localization of sequences that influence basal and cell type-specific activity of the murine mdr2 promoter. (1996) (2)
- Bruceantin: an inhibitor of protein biosynthesis (1974) (1)
- Abstract 4230: Senescence reversion contributes to acquired drug resistance (2012) (1)
- Tubulin Proteomics in Cancer (2008) (1)
- Degradation of DNA by bleomycin and FE(II) (1977) (1)
- Abstract A33: in ovarian cancer cell lines resistant to microtubule-stabilizing agents, expression of IGF2 and ABCB1 is increased and IGF1R inhibition restores drug sensitivity (2010) (1)
- Antiproliferative activity of a phenolic extract from a native Chilean Amaranthaceae plant in drug-resistant ovarian cancer cell lines (2011) (1)
- A Simple Assay for Bleomycin Activity: Degradation of Radioactive DNA to Acid-Soluble Products (1,2) (1979) (1)
- Total Synthesis and Preliminary Biological Evaluations of 15(R) and 15(S) Aza-dEpoB: A Mitsunobu Inversion at C-15 in Pre-Epothilone Fragments. (2000) (1)
- Structural and Functional Analysis of the Mouse rndrlb Gene Promoter * (2001) (1)
- 12,13 Epoxytrichothecenes and simaroubolides: inhibitors of protein synthesis (1975) (1)
- Abstract 5472: Loss of TSC2 function predicts optimal therapeutic response to combinations of MEK and mTOR inhibitors (2011) (1)
- The electronic structure of iron complexes of bleomycin (1983) (1)
- 1339 – INTERACTION OF BLEOMYCIN WITH DNA (1977) (1)
- Introduction. The novel microtubule inhibitor vinflunine. (2008) (1)
- Taxol: Just how big is its promise? (1993) (0)
- The multidrug transporter p glycoprotein is specifically labeled by an alpha 1 adrenergic photoaffinity probe iodoarylazidoprazosin (1989) (0)
- Abstract IA9-1: Is taxol resistance related to tubulin isotypes? (2010) (0)
- Photoincorporation of a Paclitaxel Photoaffinity Analogue into the N-Terminal 31 Amino Acids of β-Tubulin (1994) (0)
- Heterogeneous forms of p glycoprotein in multidrug resistant j7742 cells (1989) (0)
- TUBULIN PROTEOMICS: TOWARDS BREAKING THE CODE1 (2014) (0)
- Abstract 4687: The PI3K inhibitor GDC-0941 is synergistic with lapatinib, and mediates endocrine sensitivity in uterine papillary serous carcinoma (2014) (0)
- Exome sequencing identifies germline mutations involving novel single nucleotide polymorphisms within DNA repair pathway genes in uterine serous carcinoma (2014) (0)
- Abstract 2678: Molecular signature of drug action for microtubule stabilizing agents (2010) (0)
- Stereoselective Syntheses and Evaluation of Compounds in the 8‐ Desmethylepothilone A Series: Some Surprising Observations Regarding Their Chemical and Biological Properties. (1997) (0)
- Total Synthesis of (‐)‐Epothilone B (VIII): An Extension of the Suzuki Coupling Method and Insights into Structure‐Activity Relationships of the Epothilones. (1997) (0)
- The response of five primary ovarian cancer cell lines to taxol compared to the results of extreme drug resistance (EDR) assays (2005) (0)
- Studies on the mechanism of extrachromosomal gene amplification in tumors (1992) (0)
- Correction: Exploiting MEK Inhibitor-Mediated Activation of ERα for Therapeutic Intervention in ER-Positive Ovarian Carcinoma (2016) (0)
- ANALOGS OF CAMPTOTHECIN (1975) (0)
- Synthesis of Novel Taxol Analogues and Evaluation of Their Biological Activities. (1997) (0)
- Inhibition of insulin-like growth factor signaling in ovarian carcinoma cells significantly potentiates paclitaxel cytotoxicity (2007) (0)
- A New Paclitaxel Photoaffinity Analogue with a 3‐(4‐Benzoylphenyl) propanoyl Probe for Characterization of Drug‐Binding Sites on Tubulin and P‐Glycoprotein. (1996) (0)
- Abstract 2512: Epothilone B enhances surface EpCAM expression in ovarian cancer cells (2010) (0)
- Erratum: Exploiting MEK Inhibitor-Mediated Activation of ERα for Therapeutic Intervention in ER-Positive Ovarian Carcinoma (PLoS ONE (2016) 11, 3 (e0151750), 10.1371/journal.pone.0151750) (2016) (0)
- A Symposium in Honor of Richard G. Powell, a Long-Time Associate Editor of the Journal of Natural Products. (2015) (0)
- Iron Bleomycin: A Hemelike Complex that Catalyzes the Cleavage of DNA by Molecular Oxygen (1982) (0)
- A novel combination of a MEK inhibitor and fulvestrant shows synergistic antitumor activity in estrogen receptor-positive ovarian carcinoma (2011) (0)
- Abstract A35: Proteomic and transcriptional profiling reveal differential responses to combined MEK and PI3K-mTOR network inhibition in basal-like and mesenchymal subtypes of triple negative breast cancer (2015) (0)
- Discodermolide induces ER stress in A549 cells while causing accelerated senescence and cell death (2006) (0)
- The Plant Alkaloids (0)
- The Synthesis and Evaluation of 12,13-Benzodesoxyepothilone B: A Highly Convergent Route. (1999) (0)
- Abstract 1809: Reversal of Taxol resistance in ovarian cancer cell lines by IGF pathway inhibition (2010) (0)
- Abstract 1228: Resistance to discodermolide, a microtubule stabilizing agent and senescence inducer, is 4E-BP1 dependent (2011) (0)
- The PI3K inhibitor GDC-0941 is synergistic with lapatinib and mediates endocrine sensitivity in uterine papillary serous carcinoma via AKT (2014) (0)
- Abstract 2789: Interaction of (+)-discodermolide-Taxol hybrids with microtubules (2012) (0)
- Utilization of Photoaffinity Labeling to Investigate Binding of Microtubule Stabilizing Agents to P-Glycoprotein and β-Tubulin. (2022) (0)
- Abstract 664: Polymerization of human βIII-tubulin is distinct from βI-tubulin in a cell-free system (2011) (0)
- Defining optimal combinations of PI3K/Akt/mTOR and Ras/Raf/MAPK pathway inhibitors for use in endometrial cancer (2014) (0)
- New Generation Taxoids and Hybrids of Microtuble-Stabilizing Anticancer Agents (2001) (0)
- Abstract 833: Photolabeling of β-tubulin isotypes by radiolabeled 2-(m-azidobenzoyl)taxol (2014) (0)
- Abstract 482: Atypical expression of βV-tubulin in secretory cells of the fallopian tube as a biomarker for early dysplasia (2016) (0)
- Abstract 4496: Differential inhibition by microtubule stabilizing agents of 2-(m-azidobenzoyl)Taxol photoaffinity labeling of tubulins from different eukaryotic sources. (2013) (0)
- ISOCAMPTOTHECIN, SYNTHESIS AND BIOLOGICAL ACTIVITY IN THE CAMPTOTHECIN SERIES (1973) (0)
- Microtubule-drug interactions studied by Hydrogen-Deuterium exchange and mass spectrometry. (2006) (0)
- A Role for Progesterone in Multidrug Resistance (1997) (0)
- Taxol and Other Molecules That Interact with Microtubules (2002) (0)
- Multi-targeted Suppression of the RAS-AKT Signaling Network in NSCLC (2007) (0)
- DNA degradation by activated iron-bleomycin (1981) (0)
- Effects of cytochalasins on the macrophage-like cell line J774.16 (1982) (0)
- 35 TAXOL NEUROTOXICITY IN VIVO (1984) (0)
- Abstract 4224: MiR-7 and its novel target regulate sensitivity to microtubule stabilizing agents (2012) (0)
- Biosynthesis of Multidrug Resistance‐Associated Glycoproteins in J774.2 Multidrug Resistant Cells (1987) (0)
- The Rational Design of Antiviral Agents (1971) (0)
- Abstract 4152: Therapeutic targeting of the estrogen receptor in ovarian carcinoma by MEK inhibition (2010) (0)
- 8 Tubulin Proteomics in Cancer (0)
- Tubulin-Eribulin complex (2016) (0)
- Abstract 1229: The next-generation taxanes, SB-T-1214 and SB-CST-10202, exhibit distinct inhibitory effects on photolabeling of β-tubulin from different eukaryotic sources (2016) (0)
- Triphenylmethane dyes as inhibitors of E. coli RNA polymerase (1973) (0)
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What Schools Are Affiliated With Susan Band Horwitz?
Susan Band Horwitz is affiliated with the following schools:
