Susan L. Swain | Academic Influence

Susan L. Swain's AcademicInfluence.com Rankings

Susan L. Swain

Biology

#4958

World Rank

#7313

Historical Rank

#1779

USA Rank

Immunology

#261

World Rank

#272

Historical Rank

#65

USA Rank

biology Degrees

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Biology

Susan L. Swain's Degrees

Bachelors Biology University of California, Berkeley
PhD Immunology Stanford University

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Why Is Susan L. Swain Influential?

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According to Wikipedia, Susan L. Swain is a professor of pathology and former director and president of the Trudeau Institute, NY. She was president of the American Association of Immunologists in 2004/5. Biography Swain was born in Columbus, Ohio. Her father was a professor of mathematics; her mother, a journalist. She attended Oberlin College, majoring in biology, and received her Ph.D. in immunology from Harvard Medical School. In 1976 she took her first academic appointment as lecturer and research biologist at the University of California, San Diego in La Jolla. She stayed at UCSD, becoming professor of biology in 1989, until her appointment as director and Edward C. Brewster Chair of the Trudeau Institute . She also served as president and president emeritus of the Trudeau Institute. Since 2010 she has been professor of pathology at the University of Massachusetts Medical School, Worcester, MA.

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Susan L. Swain's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge (2007) (1398)
IL-4 directs the development of Th2-like helper effectors. (1990) (1344)
Reciprocal regulation of polarized cytokine production by effector B and T cells (2000) (881)
Interleukin 18 (2001) (699)
Expanding roles for CD4+ T cells in immunity to viruses (2012) (697)
T Cell Subsets and the Recognition of MHC Class (1983) (655)
T cell memory. (1998) (620)
Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles (1994) (593)
Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. (1994) (580)
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. (1996) (529)
Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis (1997) (527)
Class II-independent generation of CD4 memory T cells from effectors. (1999) (489)
Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development (1991) (439)
CD4 Effector T Cell Subsets in the Response to Influenza (2002) (385)
Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge1 (2009) (379)
IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells (2003) (355)
Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells (2000) (352)
Generation and in vivo persistence of polarized Th1 and Th2 memory cells. (1994) (347)
Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen1 (2000) (329)
Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection (2006) (326)
Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. (1995) (314)
IL-10 Deficiency Unleashes an Influenza-Specific Th17 Response and Enhances Survival against High-Dose Challenge1 (2009) (293)
From Naive to Memory T Cells (1996) (287)
Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. (1991) (280)
Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements (1992) (266)
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation (2005) (266)
Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice (1999) (261)
The specific direct interaction of helper T cells and antigen-presenting B cells. (1986) (255)
CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly (2003) (254)
Antigen-independent changes in naive CD4 T cells with aging (1996) (248)
Exposure to Movie Smoking: Its Relation to Smoking Initiation Among US Adolescents (2005) (245)
IL-7: maintaining T-cell memory and achieving homeostasis. (2005) (245)
Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. (1987) (242)
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function. (1981) (241)
Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals. (1996) (238)
CD4+ T cell effectors can become memory cells with high efficiency and without further division (2001) (215)
Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection (2012) (214)
In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. (1998) (210)
CD4 T Cell-Mediated Protection from Lethal Influenza: Perforin and Antibody-Mediated Mechanisms Give a One-Two Punch1 (2006) (210)
Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma (1991) (208)
Entry of naive CD4 T cells into peripheral lymph nodes requires L- selectin (1994) (206)
The specific direct interaction of helper T cells and antigen- presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells (1987) (191)
Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. (2012) (190)
Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays (1983) (188)
CD4 T cell responses to influenza infection. (2004) (187)
Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion (1995) (183)
Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor. (1992) (182)
Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation1 (2000) (182)
Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells. (1987) (180)
Why Aging T Cells Fail: Implications for Vaccination (2006) (180)
Cytotoxic CD4 T Cells in Antiviral Immunity (2011) (180)
Memory CD4+ T cells induce innate responses independently of pathogen (2010) (175)
T-cell immunosenescence: lessons learned from mouse models of aging (2009) (174)
CD4+ T‐cell memory: generation and multi‐faceted roles for CD4+ T cells in protective immunity to influenza (2006) (170)
Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. (1988) (169)
Inflammatory Cytokines Overcome Age-Related Defects in CD4 T Cell Responses In Vivo1 (2004) (169)
Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. (1995) (168)
Age-associated increase in lifespan of naïve CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects (2009) (159)
E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination (1999) (155)
Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus1 (2007) (144)
CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. (1990) (137)
Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens. (1984) (135)
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor (1982) (134)
Helper T cell differentiation. (1999) (122)
The Role of IL4 and IL5: Characterization of a Distinct Helper T Cell Subset that makes IL4 and IL5 (Th2) and Requires Priming before Induction of Lymphokine Secretion (1988) (122)
T-cell memory: new perspectives. (1993) (122)
From naive to effector ‐ alterations with aging (1997) (121)
The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. (1995) (120)
The potential of CD4 T‐cell memory (2010) (120)
Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen (2005) (117)
Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen. (1981) (117)
IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. (2009) (117)
Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2 (2014) (115)
Single cell analyses of cytokine production. (1997) (115)
Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ1 (2000) (115)
The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression (2002) (114)
Rapid default transition of CD4 T cell effectors to functional memory cells (2007) (108)
Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen. (1993) (107)
Lymphokines and the immune response: the central role of interleukin-2. (1991) (106)
Homeostasis and the age-associated defect of CD4 T cells. (2005) (106)
Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. (1996) (104)
TGF-β1: immunosuppressant and viability factor for T lymphocytes (1999) (104)
Repeated stimulation of CD4 effector T cells can limit their protective function (2005) (103)
PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. (2016) (102)
Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection (2014) (102)
Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. (1990) (100)
Uneven distribution of MHC class II epitopes within the influenza virus. (2006) (94)
Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection (2013) (91)
The Lyt phenotype of a long‐term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly‐1 cells (1981) (91)
Acculturation and tobacco use among Chinese Americans. (2004) (91)
Age-associated declines in immune system development and function: causes, consequences, and reversal. (2009) (85)
Role of antigen‐presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages (1994) (82)
IFN-γ Acts Directly on Activated CD4+ T Cells during Mycobacterial Infection to Promote Apoptosis by Inducing Components of the Intracellular Apoptosis Machinery and by Inducing Extracellular Proapoptotic Signals1 (2007) (80)
Transcriptional repression of the IL-2 gene in Th cells by ZEB. (1998) (80)
Xenogeneic human anti-mouse T cell responses are due to the activity of the same functional T cell subsets responsible for allospecific and major histocompatibility complex-restricted responses (1983) (78)
Persistent Depots of Influenza Antigen Fail To Induce a Cytotoxic CD8 T Cell Response1 (2007) (78)
High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines. (1998) (78)
T cell responses to influenza virus infection: effector and memory cells. (2004) (77)
Regulation of CD4+ T‐cell contraction during pathogen challenge (2010) (77)
Interferon g Eliminates Responding CD4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated CD4 T Cells (2000) (75)
B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity. (1991) (73)
Helper cells activated by allogeneic H-2K or H-2D differences have a Ly phenotype distinct from those responsive to I differences. (1979) (73)
IL4 dictates T-cell differentiation. (1993) (73)
SAP Is Required for Th Cell Function and for Immunity to Influenza1 (2006) (72)
Memory CD4+ T-cell–mediated protection depends on secondary effectors that are distinct from and superior to primary effectors (2012) (72)
Regulation of T cell subsets from naive to memory. (1998) (71)
Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line. (1981) (71)
B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6. (1991) (71)
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age (2015) (71)
Multipronged CD4+ T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus (2013) (71)
Environmental and Intrinsic Factors Lead to Antigen Unresponsiveness in CD4+ Recent Thymic Emigrants from Aged Mice1 (2007) (68)
Hallmarks of CD4 T cell immunity against influenza (2011) (68)
IL-15 supports the generation of protective lung-resident memory CD4 T cells (2017) (64)
Transferable Anergy: Superantigen Treatment Induces CD4+ T Cell Tolerance That Is Reversible and Requires CD4−CD8− Cells and Interferon γ (1997) (63)
Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells (2007) (61)
T-Cell Subsets: Who does the polarizing? (1995) (61)
T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines (2016) (61)
Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects (2010) (61)
The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines. (2000) (60)
B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors (1987) (60)
Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. (2012) (60)
Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection (2015) (59)
Influencing the fates of CD4 T cells on the path to memory: lessons from influenza (2008) (59)
Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. (1992) (58)
CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy (1992) (58)
Small subunit of I–A subregion antigens determines the allospecificity recognized by a monoclonal antibody (1980) (57)
Interleukin 18: tipping the balance towards a T helper cell 1 response. (2001) (57)
Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells. (1985) (56)
Krüppel‐like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL‐17 expression during Th17 differentiation (2011) (55)
Regulation of the development of distinct subsets of CD4+ T cells. (1991) (52)
CD4 T cell development and cytokine polarization: an overview (1995) (50)
Helper T cell memory: more questions than answers. (1992) (49)
TGF-beta1: immunosuppressant and viability factor for T lymphocytes. (1999) (49)
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection (2017) (48)
Regulation of isotype production by IL-4 and IL-5. Effects of lymphokines on Ig production depend on the state of activation of the responding B cells. (1989) (47)
T Cell Replacing Factors in the B Cell Response to Antigen 1 (1982) (46)
TLR-Activated Dendritic Cells Enhance the Response of Aged Naive CD4 T Cells via an IL-6–Dependent Mechanism (2010) (46)
The generation and maintenance of memory T and B cells. (1999) (45)
Age-related changes in CD4 T cells of T cell receptor transgenic mice (1997) (45)
CD28 and ITK signals regulate autoreactive T cell trafficking (2013) (45)
Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses1 (2008) (44)
CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency. (2004) (44)
Effector CD4+ T Cells Generate Intermediate Caspase Activity and Cleavage of Caspase-8 Substrates1 (2005) (44)
The effector to memory transition of CD4 T cells (2008) (42)
New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza (2016) (41)
SAP Enables T Cells to Help B Cells by a Mechanism Distinct from Th Cell Programming or CD40 Ligand Regulation1 (2008) (39)
The significance of T-B collaboration across haplotype barriers. (1977) (39)
Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function (2013) (38)
Partial purification and characterization of a BCGFII from EL4 culture supernatants. (1984) (38)
Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells. (2002) (38)
CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent (2014) (37)
Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4+ T Cell Defects1 (2008) (37)
Evidence for two distinct activation states available to B lymphocytes. (1984) (37)
Tc 17 , a Unique Subset of CD 8 T Cells That Can Protect against Lethal Influenza Challenge 1 (2009) (37)
Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells. (2003) (36)
Consequences of the Direct Interaction of Helper T Cells with B Cells presenting Antigen (1987) (35)
Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation* (2007) (35)
Negative allogeneic effects in vitro. I. Allogeneic T cells markedly suppress the secondary antibody-forming cell response. (1977) (35)
Erratum: CD4+ T-cell memory: Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza (Immunological Reviews (2006) 211, (8-22)) (2006) (34)
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells (2015) (34)
Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory (2016) (34)
Regulation of memory CD4 T cells: generation, localization and persistence. (2002) (34)
CD4 T-cell memory can persist in the absence of class II. (2000) (34)
Control of innate immunity by memory CD4 T cells. (2011) (34)
Alloreactivity, the Development of the T Cell Repertoire and the Understanding of T Cell Function (1978) (33)
IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo (2017) (32)
Analysis of CD4+ T cells that provide contact-dependent bystander help to B cells. (1992) (32)
CD4 T cells producing IFN‐γ in the lungs of mice challenged with mycobacteria express a CD27‐negative phenotype (2004) (32)
Effect of age on naive CD4 responses: impact on effector generation and memory development (2002) (32)
Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). (1987) (31)
Regulation of the IgM and IgA anti-dextran B1355S response: synergy between IFN-gamma, BCGF II, and IL 2. (1985) (31)
Ly phenotypes and MHC recognition: the allohelper that recognizes K or D is a mature Ly123 cell. (1979) (31)
Continuously proliferating allospecific T cells. I. Specificity of cooperation with allogeneic B cells in the humoral antibody response to sheep erythrocytes (1979) (27)
Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection (2012) (27)
Mouse T-lymphocyte subpopulations: relationships between function and Lyt antigen phenotype. (1980) (25)
Key research opportunities in immune system aging. (2009) (25)
Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation (2019) (24)
Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful (2013) (23)
c‐FLIPS reduces activation of caspase and NF‐κB pathways and decreases T cell survival (2008) (23)
Fine specificity mapping of two allospecific T cell lines: recognition of private specificities in the H‐2 IA subregion (1981) (23)
The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age. (2017) (23)
Frequency of allogeneic helper T cells responding to whole H-2 differences and to an H-2K difference alone. (1979) (22)
Functionally Diverse Subsets in CD4 T Cell Responses Against Influenza (2009) (22)
Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rIL-4 in vivo. (1996) (22)
Negative allogeneic effects in vitro. II. Mapping of histocompatibility differences leading to allosuppression. (1977) (21)
Distinct lymphokine production by CD4+ T cells isolated from mucosal and systemic lymphoid organs. (1993) (19)
IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans (2016) (19)
IL-2 receptor (Tac antigen) protein expression is down-regulated by the 5'-untranslated region of the mRNA. (1990) (18)
Analysis of histocompatibility requirements for proliferative and helper T cell activity. T cell populations depleted of alloreactive cells by negative selection (1980) (18)
Role of antigen in the B cell response. Specific antigen and the lymphokine IL-5 synergize to drive B cell lymphoma proliferation and differentiation to Ig secretion. (1988) (18)
Production of Con A-induced helper T cell replacing factor requires a T cell and an Ia-positive non-T cells. (1980) (18)
Aging and immune function Summary of a workshop held at Trudeau Institute, Saranac Lake, NY (2005) (17)
Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes (2003) (17)
From naive to memory (1998) (17)
Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition. (1981) (17)
Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza (2016) (17)
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion (1982) (16)
Erratum to: Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful (2013) (15)
B Cell Immunodeficiency Fails to Develop in CD4-Deficient Mice Infected with BM5: Murine AIDS as a Multistep Disease1 (2001) (15)
TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. (1996) (15)
Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. (1994) (14)
PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. (2016) (14)
Regulation of the immune response T-cell interactions. (1982) (13)
Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza? (2019) (13)
Role of Ia-positive cells in the production of T cell-replacing factors: blocking of factor production with anti-Ia serum. (1980) (13)
Mechanism of allosuppression: evidence for direct suppression of responding B cells. (1978) (13)
c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival. (2008) (13)
CD4 T cell anergy in murine AIDS: costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells. (1997) (12)
Multifunctional CD 4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection (2012) (12)
Coclustering of CD 4 ( L 3 T 4 ) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells (11)
Vaccines against pandemic influenza. (2007) (11)
Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus (2018) (11)
Polarized patterns of cytokine secretion (1993) (11)
Immunosuppressive ATS. V. Analysis of the effect of anti-thymocyte serum on T lymphocyte subsets. (1982) (11)
Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza. (2014) (10)
Association of Ly phenotypes, T cell function and MHC recognition. (1980) (10)
Lymphokine-mediated activation of a T cell-dependent IgA antipolysaccharide response. (1983) (9)
Role of T cells in the B-cell response: glutaraldehyde-fixed T-helper hybridoma cells synergize with the lymphokine IL-4 to induce B-cell activation and proliferation. (1991) (8)
Effector functions of helper T cells. (1993) (8)
Immune senescence: new insights into defects but continued mystery of root causes. (2013) (7)
Influenza Vaccine–Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production (2020) (7)
SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells. (2006) (7)
Interleukin 27 R regulates CD 4 + T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection (2015) (7)
Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis1 (2002) (7)
Effector CD 4 T Cells Generate Intermediate Caspase Activity and Cleavage of Caspase-8 Substrates 1 (2005) (5)
Lymphocyte activation and effector functions: Editorial overview Lymphocytes: the ultimate computers? (1994) (5)
Strong influenza-induced TFH generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection (2022) (4)
Virus-induced natural killer cell lysis of T cell subsets. (2020) (4)
Lymphocyte effector functions (2003) (4)
9 – B Cell and T Cell Growth Factors (1987) (4)
Characterization of T and B antigen-binding cells for beta-galactosidase. II. T antigen-binding cells. (1976) (4)
CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation (2020) (4)
Regulation of the development of helper T cell subsets (1991) (4)
Understanding the Heterogeneous Population of Age-Associated B Cells and Their Contributions to Autoimmunity and Immune Response to Pathogens. (2020) (4)
Induction of the H-2 D antigen during B cell activation. (1989) (3)
Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful (2013) (3)
Stimulation of gut-associated lymphoid cells by IL-4 and B-cell growth factor II. (1988) (3)
Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates. (2021) (3)
Do Ly Phenotypes Correlate with Function or with MHC Determinant Recognized? (1978) (2)
IL-2 produced by memory CD4 T cells synergizes with influenza A virus to amplify detrimental lung inflammation (IRC10P.404) (2015) (2)
Grand Challenges in Immunological Memory (2010) (2)
B cell surface glycoprotein induced during growth response: molecular structure and expression pattern. (1987) (2)
Some Immunological Mysteries (1981) (2)
Thanks for the Memory!1 (2005) (2)
Role of helper T cells in the B cell response. (1989) (2)
Characterization of T and B antigen-binding cells for beta-galactosidase. I. beta-galactosidase-binding cells in the thymus and spleen of normal mice. (1976) (2)
“An Intrinsic Program Determines Key Age-Associated Changes in Adaptive Immunity That Limit Response to Non-Pathogens” (2021) (2)
Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza (2022) (2)
Tc17, a new subset of CD8 T cells (2008) (2)
Role for Blimp-1 in the generation and function of cytotoxic CD4 effector T cells identified by NKG2A/C/E expression (P6046) (2013) (1)
Characterization of T and B antigen-binding cells for beta-galactosidase. III. Independence of antigen-binding cells in normal animals from antigenic stimulation. (1976) (1)
Negative Allogeneic Effects in Vitro (1977) (1)
Antigen presentation and the regulation of CD4 memory generation to influenza (2006) (1)
Responses at Lower Doses of Antigen Cell Generation: Faster, More Effective Qualitative Changes Accompany Memory T (2000) (1)
B cell growth factor interactions. (1987) (1)
717 Inhibition of specific IgE antibody formation by naked plasmid DNA immunization (1996) (1)
IgD + age‐associated B cells are the progenitors of the main T‐independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged (2022) (1)
IL-2 and IL-6 cooperate to enhance the generation of effectors from aged human CD8 T cells to live influenza virus (2012) (1)
T-cell factors that promote B-cell proliferation and differentiation. (1985) (1)
CD4 Effectors Need to Recognize Antigen Locally to Become Cytotoxic CD4 and Follicular Helper T Cells (2020) (1)
CD4 T Cell Immunity to Viral Infection (2016) (1)
Memory CD4+ T cell-derived secondary effectors are distinct from and functionally superior to primary effectors arising from naïve cells (152.33) (2011) (1)
Lymphokines and the immune responeses: the central role interleukine-2. Curr. (1991) (1)
Critical role of cognate interactions in the response of small, high-density B cells. (1990) (1)
This information is current as Thymic Emigrants from Aged Mice Recent + Antigen Unresponsiveness in CD 4 Environmental and Intrinsic Factors Lead to (2007) (1)
Inflammatory cytokines can reverse the aged phenotype and restore the in vivo function of CD4 T cells from aged mice (2001) (0)
CD4 T cell memory of prior influenza infections regulate new CD4 and CD8 T cell responses (43.3) (2007) (0)
The direct impact of key cytokines on memory effectors from older adult human CD8+ T cells to live influenza virus (P4297) (2013) (0)
Mechanisms of age-associated T cell defects: With age naïve CD4 T cells become Th1 prone, make increased OPN and acquire epigenetic changes in methylation of Type I and 2 cytokine loci consistent with that profile (122.8) (2012) (0)
The role of IA in G-cell activation. (1981) (0)
Differentiation Cytokine-Driven Expansion and Antigen-Dependent and Late Naive CD 4 T Cells to Effectors , Early Two Distinct Stages in the Transition from (2000) (0)
35TH FORUM IN IMMUNOLOGY - DISCUSSION (1991) (0)
CD4 T cell memory of prior influenza infections regulate new CD4 and CD8 T cell responses (2007) (0)
T Cells and Immunity to Influenza (2006) (0)
Generation of tissue-restricted CD4 effectors (TFH and ThCTL) requires signals from local antigen & infection during the effector phase (2019) (0)
Aging and immunity (WS-105) Chairpersons: Toshikazu Yoshikawa, Janko Nikolich-Žugich (2010) (0)
Late cognate antigen interactions are required for CD4+ T cell survival during influenza infection. (P6146) (2013) (0)
Cytotoxic effector CD4 T cells express NKG2C/E and are defined by a unique program dependent on Blimp-1. (IRC8P.482) (2014) (0)
Augmenting Ag presentation at the “CD4 memory checkpoint” can overcome age-associated “defects” in CD4 helper response and enhance vaccination. (2017) (0)
Can Age-Associated B cells (ABC) Contribute to Anti-Viral Immunity? (2019) (0)
Cd4 positive t cell responses in vivo to antigen pulsed presenting cells (1992) (0)
Maintenance of immune diversity during an effector T cell response in face of antigen selection (IRC8P.444) (2015) (0)
The T-box transcription factors T-bet and Eomes repress protective Th17 CD4 T cell responses against Influenza A Virus (2020) (0)
Memory CD4 T cells protect against influenza A virus through both an interferon gamma-dependent and multiple interferon gamma-independent mechanisms (105.31) (2012) (0)
Cytotoxic CD4 Development Requires CD4 Effectors to Concurrently Recognize Local Antigen and Encounter Infection-Induced IL-15 (2022) (0)
Memory CD4 T cells drive emergence of viral escape mutants during influenza challenge in the absence of CD8 T cells and B cells (49.6) (2011) (0)
To Induce a Cytotoxic CD8 T Cell Response Persistent Depots of Influenza Antigen Fail (2013) (0)
PSGL-1, an immune checkpoint regulator that promotes T cell exhaustion in chronic viral infection and cancer (VIR10P.1166) (2015) (0)
Infectionagainst Lethal Influenza Virus Gamma Interferon and Perforin Mediate Multifunctional CD4 Cells Expressing (2012) (0)
IL-10 suppresses influenza-specific Th17 responses and is detrimental during high-dose primary challenge (43.8) (2009) (0)
TLR activated APC enhance the response of aged naïve CD4 T cells via an IL‐6 dependent mechanism (2008) (0)
Well in Primary and Memory Responses Mice Generate CD4 T Cells That Function Bone Marrow Precursor Cells from Aged (2008) (0)
Thespecific direct interaction ofhelper Tcells and antigen-presenting B cells (microtubule organizing center/Golgi apparatus/immunofluorescence) (1986) (0)
Changes in Naive CD 4 T Cells (2002) (0)
Characterization of Metal by GEM Detector Using Ion Beam Facility at IOP (2021) (0)
Role of Krüppel-like factor 4 (Klf4) in regulation of T cell number and TH-17 differentiation (139.12) (2010) (0)
Late antigen recognition at the memory checkpoint is necessary for CD4+ T cell memory formation. (IRC9P.708) (2014) (0)
1822 B CELL GROWTH FACTOR : PRODUCTION AND ASSAY chromatography (2003) (0)
IL-2 and IL-6 cooperate to enhance the generation of effectors from aged human CD8 T cells to live influenza virus (113.34) (2012) (0)
Helper T cells: polarized patterns of cytokine secretion. (1993) (0)
ThCTL expressing NKG2A/C/E represent a unique CD4 cytotoxic effector subset. (2016) (0)
Antigen Presenting Cells as Drivers of Specialized Immune Responses (2016) (0)
Novel regulation of ILC by memory CD4 T cells during protective responses against influenza A virus (2016) (0)
Construction of a Single GEM Detector Using Indigenous Anode Plate (2021) (0)
ALLOHELP TO H-2K APPEARS TO DEPEND ONLY ON A MATURE LY123 T CELL (1979) (0)
A checkpoint requiring cognate antigen recognition at the effector stage is necessary for protective memory CD4 T cell generation. (2016) (0)
Longitudinal Attrition in a RDD Survey of Adolescents (2005) (0)
Role of different T-cell replacing factors (TRFs) in the proliferation and differentiation of B-cell subsets (1982) (0)
Involves a Dysregulation of Homeostasis AIDS Is Dependent on Costimulation and Induction of CD4 T Cell Changes in Murine (2002) (0)
ON THE RELATIONSHIP BETWEEN Lyt PHENOTYPES, MHC SUBREGIONS, AND T CELL FUNCTION (1980) (0)
CD4 Effectors must re-encounter Antigen Locally in the Presence of Signals from Infection to Fully Differentiate into Specialized Tissue-restricted TFH and ThCTL effectors (2021) (0)
Functional Defects the Development of Age-Associated Bim Dictates Naive CD4 T Cell Lifespan and (2010) (0)
Antigen-independ ent Changes in Naive CD4 T Cells with Aging By Phyllis-Jean Linton,* Laura Haynes,¢ Norman R.. Klinman,g (1996) (0)
Attrition, in Response to Acute Virus Differentiation and Expansion, but Not T Cell + Graded Levels of IRF4 Regulate CD8 (2014) (0)
Peptide Avidity for TCR on CD4 Effectors Determines the Extent of Memory Generation (2022) (0)
IL-15 supports the generation of lung tissue-resident memory CD4 T cells (2016) (0)
IL-2 differentially regulates perforin and FasL mediated cytotoxicity in CD4 T cells (33.10) (2009) (0)
TLR activated-dendritic cells (*) enhance the response of aged naïve CD4 T cells in vivo (52.5) (2012) (0)
CD4 memory T cells regulate mediators of lung damage during respiratory infections (130.8) (2009) (0)
Is autoimmunity good for you? The Molecular Basis of Recognition in the Immune System sponsored by the European Federation of Immunological Societies, Edinburgh, UK, September 10-12, 1990. (1991) (0)
A novel subset of lung tissue-resident memory CD4 T cells generated by influenza virus infection (MUC1P.903) (2015) (0)
Influenza-specific memory CD4 T cells regulate acute inflammation independent of innate immune recognition (130.10) (2009) (0)
Measurement of Ion Backflow with GEM-Based Detectors (2021) (0)
CD4 T cell responses to influenza infection CD4 T cell responses to influenza infection (2019) (0)
Give a One-Two Punch Influenza : Perforin and Antibody-Mediated CD 4 T Cell-Mediated Protection from Lethal (2006) (0)
The central role of dendritic cell-produced IL-6 signals in reversing age-related CD4 T cell defects (P4226) (2013) (0)
Role of ia positive cells in the production of t cell replacing factors: inhibition of factor production by anti ia sera. Abstr. (1980) (0)
Age-associated increase of IL-6 dampens anti-tumor immune responses through attenuating Th1 differentiation of tumor-specific CD4 T cells (TUM7P.928) (2014) (0)
Influenza‐specific CD4 effectors utilize perforin for cytolytic function and protection in vivo (2008) (0)
Regulation of T cell subsets from naive to memory : T cell response to tumors (1998) (0)
Influenza Vaccine-Induced CD4 Effectors Require Ag Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Ab Production (2021) (0)
Secondary CD4+ T cell effectors retain heterogeneity during recall responses but are functionally superior to primary effectors (163.8) (2012) (0)
Generation of specialized CD4 subsets: TFH and ThCTL, requires signals from local antigen & infection during the effector phase. (2018) (0)
Cytolytic CD4 cells in the lungs of influenza-infected mice (49.17) (2011) (0)
Modulation of lung environment and new T cell responses by flu‐primed CD4 memory T cells (2008) (0)
Lifespan of T cells: Differential requirements for the survival of young and aged naïve CD4 T cells (2008) (0)
Proinsulin synergizes with anti-CD20 to delay/ prevent the onset of T1D in NOD mice WS/PP-105-03 Stem cell and hormonal rejuvenation of the thymus to reverse immunodeﬁciency and manipulate immune competence in mice and humans (2010) (0)
In Vivo Responses Age-Related Defects in CD4 T Cell Inflammatory Cytokines Overcome (2004) (0)
Varying pMHC-TCR affinity at the memory checkpoint alters the number and phenotype of memory CD4 T cells. (2018) (0)
Characterization of T and B Antigen-Binding Cells for β-Galactosidase (1976) (0)
The effects of key pro-inflammatory cytokines on influenza vaccine induced memory CD8+ T cell homeostasis (VAC2P.938) (2014) (0)
Th Cells by ZEB Transcriptional Repression of the IL-2 Gene in (1998) (0)
The Lifespan of Naïve CD4 T cells is a Critical Determinant for the Cellular Aging in Periphery (46.2) (2009) (0)
current as T Cells + the Induction of Profibrotic CD 8 IL-21 Promotes Pulmonary Fibrosis through (2015) (0)
Erratum to: Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful (2013) (0)
Visualization of Direct T-B Cell Interaction (1987) (0)
CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated. (2023) (0)
A unique population of induced age associated B cells (iABC) are generated in aged mice in response to IAV (IRC3P.465) (2014) (0)
IL-6 Response of Aged Naive CD 4 T Cells via an TLR-Activated Dendritic Cells Enhance the (2010) (0)
I. Specificity of Coopera t ion with Allogeneic B Cells in the Humora l Ant ibody Response to Sheep Erythroeytes* (2003) (0)

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