Susan Mackem

Susan Mackem's AcademicInfluence.com Rankings

Susan Mackem

Biology

#14624

World Rank

#18422

Historical Rank

#2881

USA Rank

Pathology

#228

World Rank

#389

Historical Rank

#42

USA Rank

biology Degrees

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Biology

Why Is Susan Mackem Influential?

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According to Wikipedia, Susan Marie Mackem is an American anatomic pathologist and physician-scientist. She researches vertebrate primary axis formation and the regulation of patterning and differentiation during limb development. She is a senior investigator and head of the regulation of vertebrate morphogenesis section at the National Cancer Institute's Frederick National Laboratory for Cancer Research. She is also an attending pathologist at the National Institutes of Health Clinical Center.

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Susan Mackem's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. (2010) (776)
Soluble dominant‐negative receptor uncovers essential roles for fibroblast growth factors in multi‐organ induction and patterning (1998) (398)
Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters (1981) (339)
Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. (1996) (298)
Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. (2008) (296)
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes (1982) (269)
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy (2008) (260)
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone (2007) (247)
Kinetics of tamoxifen‐regulated Cre activity in mice using a cartilage‐specific CreERT to assay temporal activity windows along the proximodistal limb skeleton (2006) (239)
An integrative approach to understanding bird origins (2014) (229)
Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development (2010) (211)
A Near-IR Uncaging Strategy Based on Cyanine Photochemistry (2014) (163)
Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. (1997) (144)
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh (2004) (132)
Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation. (1997) (119)
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. (1981) (116)
IGF‐1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway (2011) (103)
Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes. (1980) (92)
A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses (2010) (88)
Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. (2009) (80)
Continuing organizer function during chick tail development. (1998) (79)
Recombinant limbs as a model to study homeobox gene regulation during limb development. (1994) (78)
Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life (2010) (77)
Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator. (1982) (75)
Down-Regulation of Nucleosomal Binding Protein HMGN1 Expression during Embryogenesis Modulates Sox9 Expression in Chondrocytes (2006) (71)
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. (2012) (67)
β-Catenin has sequential roles in the survival and specification of ventral dermis (2008) (64)
Abnormal Placental Development and Early Embryonic Lethality in EpCAM-Null Mice (2009) (57)
The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid. (1995) (55)
Differentiation between a promoter and regulator regions of herpes simplex virus 1: The functional domains and sequence of a movable a regulator (50)
Regulation of α Genes of Herpes Simplex Virus: The α 27 Gene Promoter-Thymidine Kinase Chimera Is Positively Regulated in Converted L Cells (1982) (46)
Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension. (2014) (46)
Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal (2011) (45)
An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism (2016) (44)
Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression. (1991) (42)
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells (2012) (41)
Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice (2011) (37)
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development (2003) (37)
Ovarian Carcinoma as a Cause of Zollinger-Ellison Syndrome Natural History, Secretory Products, and Response to Provocative Tests (1989) (35)
Tamoxifen‐dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud (2009) (35)
Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT (2016) (31)
Tracing the Evolution of Avian Wing Digits (2013) (28)
A Glucocorticoid/Retinoic Acid Receptor Chimera That Displays Cytoplasmic/Nuclear Translocation in Response to Retinoic Acid (2001) (28)
Regulation of herpesvirus macromolecular synthesis: temporal order of transcription of alpha genes is not dependent on the stringency of inhibition of protein synthesis (1981) (27)
Limb Development: The Rise and Fall of Retinoic Acid (2009) (23)
Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen (2011) (21)
John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work? (2017) (20)
Cre‐mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage‐induced pathway (2012) (20)
PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud (2016) (20)
Activation of epiblast gene expression by the hypoblast layer in the prestreak chick embryo (2001) (17)
Ventral tail bud mesenchyme is a signaling center for tail paraxial mesoderm induction (2004) (15)
Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb (1995) (14)
Do 5’Hoxd genes play a role in initiating or maintaining A-P polarizing signals in the limb? (1999) (14)
The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13 (2020) (12)
Ovarian carcinoma as a cause of Zollinger-Ellison syndrome. Natural history, secretory products, and response to provocative tests. (1989) (11)
Limb Development Takes a Measured Step Toward Systems Analysis (2009) (10)
The pleiotropic mouse phenotype extra‐toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling (2011) (10)
Sonic Hedgehog is not a limb morphogen but acts as a trigger to specify all digits (2020) (9)
Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates (2021) (7)
Regulation of alpha genes of herpes simplex virus: the alpha 27 gene promoter-thymidine kinase chimera is positively regulated in converted L cells. (1982) (7)
Limb Cells Don't Tell Time (2011) (6)
Limb-type differences in expression domains of certain chick Hox-4 genes and relationship to pattern modification for flight. (1993) (4)
Evolutionary developmental biology: Use it or lose it (2014) (4)
Tamoxifen-Dependent, Inducible Bmp2CreER Drives Selective Recombinase Activity in Early Interdigital Mesenchyme and Digit Collateral Ligaments (2015) (4)
Rethinking positional information and digit identity: The role of late interdigit signaling (2021) (3)
The Regulation of α Genes of Herpes Simplex Virus 1 (1984) (3)
A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation (2020) (3)
Developmental Biology: Extending the Limb and Body with Vectors and Scalars (2011) (3)
An integrative approach to understanding bird origins AVIAN EVOLUTION (2014) (2)
A dorsal-ventral gradient of Wnt3a/β-catenin signals control hindgut extension and colon formation. (2020) (2)
Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration (2022) (1)
Dual, separable roles of Sonic Hedgehog in limb bud patterning and expansion (2008) (0)
ReviewTracing the Evolution of Avian Wing Digits (2013) (0)
Title An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5 ′ Hoxd ‒ Gli 3 antagonism (2018) (0)
From fin to limb and back again: New insights on the evolution of limb development in the age of functional genomics (2018) (0)
Use it or lose it A comparison of the development of adapted limbs in mammals uncovers multiple avenues to digit loss and highlights that early patterning events are not untouchable by evolutionary tinkering. (2014) (0)
A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2 (2022) (0)
Chapter 15. Limb Development (2008) (0)
Sequential roles of Wnt signaling/β-catenin in mouse ventral dermal development (2008) (0)
Sonic Hedgehog control of pattern and growth can be uncoupled in the developing limb (2007) (0)
Nobel mice models provide the new insights of pathogenesis for multiple hereditary exostoses (2010) (0)
TAF7 is essential for early embryonic mouse development (2011) (0)
Morphogen or mitogen? Re‐evaluating Sonic Hedgehog function in the developing limb (2006) (0)
Mutual transcriptional repression between Gli3 and Hox13 genes determines the anterior-posterior asymmetry of the autopod (2018) (0)
Summary Direct interaction with Hoxd proteins reverses Gli 3-repressor function to promote digit formation downstream of Shh (0)

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Other Resources About Susan Mackem

en.wikipedia.org

What Schools Are Affiliated With Susan Mackem?

Susan Mackem is affiliated with the following schools:

University of Chicago