Susan S Taylor

Q: What Schools Are Affiliated With Susan S Taylor

Susan S Taylor is affiliated with the following schools: University of California, Berkeley, Weizmann Institute of Science, University of San Diego, San Diego State University, University of Michigan, University of California, San Diego, University of Chicago, Stanford University, Ruhr University Bochum, Technical University of Munich, University of Utah

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Susan S Taylor

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#385

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Susan S Taylor

Computer Science

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Machine Learning

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#281

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Artificial Intelligence

#452

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#459

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Engineering
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Susan S Taylor's Degrees

PhD Computer Science Stanford University
Masters Electrical Engineering University of California, Berkeley

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Susan S Taylor's Published Works

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Published Works

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. (1991) (1562)
Identification of a signal for rapid export of proteins from the nucleus (1995) (1205)
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. (1990) (1105)
Regulation of protein kinases; controlling activity through activation segment conformation. (2004) (998)
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. (1991) (862)
The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families (2007) (855)
Protein kinases: evolution of dynamic regulatory proteins. (2011) (739)
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism (2006) (655)
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. (1999) (650)
Fluorescence ratio imaging of cyclic AMP in single cells (1991) (643)
Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway (2015) (614)
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering (2001) (561)
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor (1993) (517)
A genetically encoded, fluorescent indicator for cyclic AMP in living cells (1999) (475)
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains (1995) (388)
Assembly of allosteric macromolecular switches: lessons from PKA (2012) (374)
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline (2002) (372)
Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence (1986) (371)
A helix scaffold for the assembly of active protein kinases (2008) (368)
Three protein kinase structures define a common motif. (1994) (341)
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. (1993) (334)
Crystal Structure of a Complex Between the Catalytic and Regulatory (RIα) Subunits of PKA (2005) (321)
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. (1984) (314)
Structural framework for the protein kinase family. (1992) (310)
PKA: a portrait of protein kinase dynamics. (2004) (306)
Dynamics of cAMP-dependent protein kinase. (2001) (305)
PKA-I Holoenzyme Structure Reveals a Mechanism for cAMP-Dependent Activation (2007) (303)
Identification of a Novel Protein Kinase A Anchoring Protein That Binds Both Type I and Type II Regulatory Subunits* (1997) (299)
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. (2013) (278)
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes (2005) (273)
Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations (1993) (273)
Structural and Functional Diversity of the Microbial Kinome (2007) (270)
ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function* (2010) (270)
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites (1984) (266)
cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer (1994) (256)
Dynamics of signaling by PKA. (2005) (249)
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. (2001) (245)
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. (1997) (237)
Structural adaptations of lactate dehydrogenase isozymes. (1977) (237)
Defining the Conserved Internal Architecture of a Protein Kinase (2010) (234)
PKA: lessons learned after twenty years. (2013) (231)
cAMP-dependent protein kinase. Model for an enzyme family. (1989) (228)
Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers (2013) (227)
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. (1990) (213)
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. (1990) (213)
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. (1998) (211)
A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. (1994) (210)
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. (2008) (209)
Uniform nomenclature for the mitochondrial contact site and cristae organizing system (2014) (208)
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module (2007) (206)
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. (2006) (201)
A template for the protein kinase family. (1993) (195)
The cAMP binding domain: an ancient signaling module. (2005) (189)
Dynamics-Driven Allostery in Protein Kinases. (2015) (189)
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase (2002) (188)
Evolution of the eukaryotic protein kinases as dynamic molecular switches (2012) (187)
Structure-function relationships in lactate dehydrogenase. (1973) (184)
How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein‐tyrosine kinase (1995) (182)
Dynamic architecture of a protein kinase (2014) (180)
Dynamics connect substrate recognition to catalysis in protein kinase A. (2010) (180)
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated (1995) (178)
Regulation of cAMP-dependent Protein Kinase Activity by Glutathionylation* (2002) (173)
NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum (1999) (170)
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. (1993) (169)
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. (2005) (162)
Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes. (1982) (162)
Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation (2013) (162)
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. (1989) (161)
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. (1993) (161)
Allosteric cooperativity in protein kinase A (2008) (156)
Structural comparisons of cAMP-dependent protein kinases I and II from porcine skeletal muscle. (1979) (154)
Structure and Allostery of the PKA RIIβ Tetrameric Holoenzyme (2012) (154)
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. (2001) (153)
Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. (1990) (139)
Designing isoform-specific peptide disruptors of protein kinase A localization (2003) (135)
Enhanced Dephosphorylation of cAMP-dependent Protein Kinase by Oxidation and Thiol Modification* (2005) (133)
Role of the Glycine Triad in the ATP-binding Site of cAMP-dependent Protein Kinase* (1997) (132)
Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. (1992) (132)
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria (2011) (132)
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. (2003) (131)
Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase. (1990) (130)
A-kinase-interacting protein localizes protein kinase A in the nucleus. (2005) (129)
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways (2007) (128)
Classification and Phylogenetic Analysis of the cAMP-Dependent Protein Kinase Regulatory Subunit Family (2002) (128)
PKR and eIF2α: Integration of Kinase Dimerization, Activation, and Substrate Docking (2005) (127)
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy (2011) (126)
Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. (1995) (126)
Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. (1996) (125)
Domain movements in protein kinases. (1994) (122)
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF (2011) (120)
Mitogenic Signaling by Ret/ptc2 Requires Association with Enigma via a LIM Domain* (1996) (120)
Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis (2015) (119)
The In Situ Structure of Parkinson’s Disease-Linked LRRK2 (2019) (119)
The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion (2013) (118)
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. (1997) (117)
cAMP activation of PKA defines an ancient signaling mechanism (2007) (117)
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling (2020) (114)
The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail*♦ (2009) (113)
Kinases and Pseudokinases: Lessons from RAF (2014) (113)
Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71. (1981) (113)
Signal transduction through the cAMP-dependent protein kinase (1993) (112)
Profile of the disulfide bonds in acetylcholinesterase. (1986) (110)
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. (1997) (109)
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. (2010) (108)
Phosphorylation of the Catalytic Subunit of Protein Kinase A (2002) (107)
Primary structures of the catalytic subunits from two molecular forms of acetylcholinesterase. A comparison of NH2-terminal and active center sequences. (1985) (106)
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. (1993) (106)
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. (1994) (105)
Identification of a molecular target for the Yersinia protein kinase A. (2007) (105)
Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. (1992) (103)
Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein (2001) (103)
PKA Type IIα Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity (2007) (103)
The protein kinase resource. (1997) (102)
Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2 (1998) (102)
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states. (1993) (100)
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. (2007) (99)
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase. (1992) (99)
Structural basis of the intrasteric regulation of myosin light chain kinases. (1992) (98)
Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases* (1996) (98)
N-myristylation of the catalytic subunit of cAMP-dependent protein kinase conveys structural stability. (1993) (96)
Signaling through dynamic linkers as revealed by PKA (2013) (95)
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). (2004) (95)
α4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins (2007) (92)
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus. (1994) (92)
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism (2003) (91)
Relationships between structural domains and function in the regulatory subunit of cAMP-dependent protein kinases I and II from porcine skeletal muscle. (1979) (90)
Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5'-adenosine. Identification of a modified lysine residue. (1979) (90)
Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. (1993) (90)
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. (2002) (89)
Evolution of allostery in the cyclic nucleotide binding module (2007) (87)
Identification of the protein kinase A regulatory RIα-catalytic subunit interface by amide H/2H exchange and protein docking (2003) (87)
Global Consequences of Activation Loop Phosphorylation on Protein Kinase A* (2009) (84)
Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. (1999) (84)
Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. (1994) (84)
cAMP‐dependent protein kinase: prototype for a family of enzymes (1988) (84)
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. (1997) (83)
Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I. (1991) (80)
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. (1999) (79)
Allostery through the computational microscope: cAMP activation of a canonical signaling domain (2015) (78)
Phosphoryl transfer by protein kinase A is captured in a crystal lattice. (2013) (78)
Kinase Regulation by Hydrophobic Spine Assembly in Cancer (2014) (77)
Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation* (2012) (77)
A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI) to the Plasma Membrane* (2012) (76)
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. (2005) (76)
Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. (1993) (75)
Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. (1998) (75)
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling (2016) (74)
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. (2003) (74)
Structural Basis for Peptide Binding in Protein Kinase A (2003) (74)
Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). (2002) (74)
A dynamic hydrophobic core orchestrates allostery in protein kinases (2017) (74)
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. (2004) (74)
Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. (1997) (73)
A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A (1995) (72)
Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. (2004) (72)
Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates. (1982) (71)
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission (2018) (71)
A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. (1988) (70)
Consequences of Lysine 72 Mutation on the Phosphorylation and Activation State of cAMP-dependent Kinase* (2005) (70)
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase. (1993) (69)
2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. (1993) (68)
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. (2006) (68)
Structure and dynamics of PKA signaling proteins. (2006) (67)
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A. (1998) (67)
Targeting and Import Mechanism of Coiled-coil Helix Coiled-coil Helix Domain-containing Protein 3 (ChChd3) into the Mitochondrial Intermembrane Space* (2012) (66)
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange (2005) (65)
Determinants of ligand binding to cAMP-dependent protein kinase. (1999) (65)
Congenital disease SNPs target lineage specific structural elements in protein kinases (2008) (65)
Dynamics of cAMP-Dependent Protein Kinase (2001) (65)
Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors. (2000) (65)
Cowpea Mosaic Virus: From the Presentation of Antigenic Peptides to the Display of Active Biomaterials (2003) (64)
Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. (1998) (64)
Covalent modification of an adenosine 3':5'-monophosphate binding site of the regulatory subunit of cAMP-dependent protein kinase II with 8-azidoadenosine 3':5'-monophosphate. Identification of a single modified tyrosine residue. (1980) (63)
Importance of the A‐helix of the catalytic subunit of cAMP‐dependent protein kinase for stability and for orienting subdomains at the cleft interface (1997) (63)
Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet (HFD) Diabetic Mice* (2013) (62)
Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design* (2010) (62)
D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor Recycling* (2009) (61)
Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit. (1998) (61)
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites (1993) (61)
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. (1999) (60)
PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. (2003) (59)
Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. (2005) (59)
cAMP-dependent Protein Kinase Regulatory Subunit Type IIβ (2004) (59)
Divalent metal ions influence catalysis and active‐site accessibility in the camp‐dependent protein kinase (1993) (59)
Differential effects of substrate on type I and type II PKA holoenzyme dissociation. (2004) (59)
A conserved helix motif complements the protein kinase core. (1993) (59)
Differential labeling and identification of the cysteine-containing tryptic peptides of catalytic subunit from porcine heart cAMP-dependent protein kinase. (1981) (59)
PKA, PKC, and AKAP localization in and around the neuromuscular junction (2001) (58)
Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. (2014) (58)
Amino acid sequence of dogfish muscle lactate dehydrogenase. (1977) (57)
Conformational differences among solution structures of the type Iα, IIα and IIβ protein kinase A regulatory subunit homodimers: Role of the linker regions (2004) (57)
Divergence in primary structure between the molecular forms of acetylcholinesterase. (1988) (56)
RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. (2004) (56)
Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. (1993) (56)
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. (2011) (56)
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 Å resolution (2002) (56)
Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). (2003) (55)
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. (1999) (55)
Catalytic subunit of cyclic AMP-dependent protein kinase: structure and dynamics of the active site cleft. (1999) (54)
Redox Regulation of cAMP-dependent Protein Kinase Signaling (2007) (54)
A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains (2008) (54)
Integrins protect cardiomyocytes from ischemia/reperfusion injury. (2013) (54)
2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. (1998) (54)
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain (2019) (53)
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. (2007) (53)
Comparative surface geometry of the protein kinase family (2009) (53)
Protein kinase resource: An integrated environment for phosphorylation research (2006) (53)
The in vitro phosphorylation of chromatin by the catalytic subunit of cAMP-dependent protein kinase. (1982) (53)
Localization and quaternary structure of the PKA RIβ holoenzyme (2012) (53)
Effect of the thermostable protein kinase inhibitor on intracellular localization of the catalytic subunit of cAMP-dependent protein kinase. (1992) (52)
Interaction of the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinase (1997) (52)
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor (2018) (51)
The Rate of NF-κB Nuclear Translocation Is Regulated by PKA and A Kinase Interacting Protein 1 (2011) (51)
Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. (1999) (51)
Isoform-specific Differences between the Type Iα and IIα Cyclic AMP-dependent Protein Kinase Anchoring Domains Revealed by Solution NMR* (2000) (51)
Divalent Metal Ions Mg²⁺ and Ca²⁺ Have Distinct Effects on Protein Kinase A Activity and Regulation. (2015) (51)
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication (1999) (51)
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. (2007) (50)
Title Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST 1G 3 BP 2 mechanotransduction pathway (2015) (50)
Regulatory subunit of cyclic AMP-dependent protein kinase I from porcine skeletal muscle: purification and proteolysis. (1978) (50)
Calcium-Dependent and -Independent Stomatal Signaling Network and Compensatory Feedback Control of Stomatal Opening via Ca2+ Sensitivity Priming[W] (2013) (50)
Disruption of Protein Kinase A Localization Using a Trans-activator of Transcription (TAT)-conjugated A-kinase-anchoring Peptide Reduces Cardiac Function* (2010) (49)
Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase. (1988) (49)
A Molecular Switch for Targeting between Endoplasmic Reticulum (ER) and Mitochondria (2008) (48)
Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. (1994) (48)
A Transition Path Ensemble Study Reveals a Linchpin Role for Mg2+ during Rate-Limiting ADP Release from Protein Kinase A† (2009) (48)
Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. (2002) (48)
A Stable α-Helical Domain at the N Terminus of the RIα Subunits of cAMP-dependent Protein Kinase Is a Novel Dimerization/Docking Motif* (1997) (48)
Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. (1995) (47)
The structural domains of cAMP-dependent protein kinase I. Characterization of two sites of proteolytic cleavage and homologies to cAMP-dependent protein kinase II. (1980) (47)
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. (2012) (47)
600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. (1999) (47)
Identification of ChChd3 as a Novel Substrate of the cAMP-dependent Protein Kinase (PKA) Using an Analog-sensitive Catalytic Subunit* (2007) (46)
Correlation of the cAMP binding domain with a site of autophosphorylation on the regulatory subunit of cAMP-dependent protein kinase II from porcine skeletal muscle. (1979) (46)
Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A* (2009) (46)
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase. (1992) (46)
Synergistic Binding of Nucleotides and Inhibitors to cAMP-dependent Protein Kinase Examined by Acrylodan Fluorescence Spectroscopy* (1997) (46)
Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)* (2011) (46)
Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. (2015) (45)
Expression of the type I regulatory subunit of cAMP-dependent protein kinase in Escherichia coli. (1986) (45)
Communication between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-Iα as Revealed by Domain-silencing Mutations* (2010) (45)
Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes* (2012) (45)
ProKinO: A Unified Resource for Mining the Cancer Kinome (2014) (44)
Crystal structure of the WD40 domain dimer of LRRK2 (2019) (44)
Protein kinase inhibition: natural and synthetic variations on a theme. (1997) (44)
C Subunits Binding to the Protein Kinase A RIα Dimer Induce a Large Conformational Change* (2004) (44)
Regulation-defective mutants of type I cAMP-dependent protein kinase. Consequences of replacing arginine 94 and arginine 95. (1993) (43)
Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation (2015) (43)
Selective protection of sulfhydryl groups in cAMP-dependent protein kinase II. (1983) (42)
Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase. (1983) (42)
Conserved spatial patterns across the protein kinase family. (2008) (41)
Dissecting the Cooperative Reassociation of the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinase (1997) (41)
Pseudokinases from a structural perspective. (2013) (41)
Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms Iα and IIβ to the Catalytic Subunit* (2001) (41)
A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. (2012) (40)
The regulatory subunit of neural cAMP-dependent protein kinase II represents a unique gene product. (1985) (40)
Purification and separation of pyridine nucleotide-linked dehydrogenases by affinity chromatography techniques. (1974) (40)
Chromosome segregation: Dual control ensures fidelity (1999) (40)
cAMP-dependent protein kinase defines a family of enzymes. (1993) (40)
Dicyclohexylcarbodiimide cross-links two conserved residues, Asp-184 and Lys-72, at the active site of the catalytic subunit of cAMP-dependent protein kinase. (1989) (40)
Tyrosines outside the Kinase Core and Dimerization Are Required for the Mitogenic Activity of RET/ptc2 (*) (1995) (39)
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: substrate-induced conformational changes. (1989) (39)
Interchain disulfide bonding in the regulatory subunit of cAMP-dependent protein kinase I. (1982) (39)
Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase (2012) (39)
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with a water-soluble carbodiimide: identification of carboxyl groups protected by MgATP and inhibitor peptides. (1990) (39)
Protein kinases: A diverse family of related proteins (1987) (39)
A 15-Residue Bifunctional Element in d-AKAP1 Is Required for Both Endoplasmic Reticulum and Mitochondrial Targeting* (2002) (38)
cAMP-dependent protein kinase and the protein kinase family. (1992) (38)
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. (2011) (38)
Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. (2006) (38)
Integration of signaling in the kinome: Architecture and regulation of the αC Helix. (2015) (38)
Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. (1991) (36)
Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase. (1993) (36)
A kinase interacting protein (AKIP1) is a key regulator of cardiac stress (2013) (36)
Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain (2017) (36)
The structure of acetylcholinesterase: relationship to its function and cellular disposition (1987) (36)
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif (2021) (36)
Antiparallel alignment of the two protomers of the regulatory subunit dimer of cAMP-dependent protein kinase I. (1987) (35)
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. (2016) (35)
An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. (2015) (35)
Consequences of cAMP and catalytic-subunit binding on the flexibility of the A-kinase regulatory subunit. (2000) (35)
Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. (1974) (35)
Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. (2012) (35)
Rethinking Pseudokinases (2008) (34)
Site-specific cyclic nucleotide binding and dissociation of the holoenzyme of cAMP-dependent protein kinase. (1982) (34)
The Expression and Intracellular Distribution of the Heat-stable Protein Kinase Inhibitor Is Cell Cycle Regulated (*) (1995) (34)
A chimeric mechanism for polyvalent trans‐phosphorylation of PKA by PDK1 (2009) (34)
PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. (2014) (34)
Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP. (1990) (34)
Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance (2017) (34)
Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer (2017) (33)
Pseudokinases: functional insights gleaned from structure. (2009) (33)
Kinetic analysis of cAMP-dependent protein kinase: mutations at histidine 87 affect peptide binding and pH dependence. (1995) (33)
Role of MgATP in the activation and reassociation of cAMP-dependent protein kinase I: consequences of replacing the essential arginine in cAMP binding site A. (1991) (33)
The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase. (1989) (32)
Backbone flexibility of five sites on the catalytic subunit of cAMP-dependent protein kinase in the open and closed conformations. (1998) (32)
cAMP-Dependent Protein Kinase (2010) (32)
Crystallization studies of cAMP-dependent protein kinase. Cocrystals of the catalytic subunit with a 20 amino acid residue peptide inhibitor and MgATP diffract to 3.0 A resolution. (1991) (32)
High affinity binding of the heat-stable protein kinase inhibitor to the catalytic subunit of cAMP-dependent protein kinase is selectively abolished by mutation of Arg133. (1994) (31)
Examination of an active‐site electrostatic node in the cAMP‐dependent protein kinase catalytic subunit (1996) (31)
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. (2004) (31)
Monoclonal antibodies as probes for functional domains in cAMP-dependent protein kinase II. (1985) (30)
Tuning the “violin” of protein kinases: The role of dynamics‐based allostery (2019) (30)
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. (2006) (30)
Two well‐defined motifs in the cAMP‐dependent protein kinase inhibitor (PKIα) correlate with inhibitory and nuclear export function (2008) (30)
Homologies in the active site regions of lactate dehydrogenases. (1976) (30)
Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Identification of a specific interchain disulfide bond. (1988) (29)
Crystal structure of the E230Q mutant of cAMP‐dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N‐terminal A helix (2005) (29)
Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding* (2014) (29)
Crystallization studies of cAMP-dependent protein kinase. Crystals of catalytic subunit diffract to 3.5 A resolution. (1985) (29)
Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity (2019) (29)
Isoform-specific targeting of PKA to multivesicular bodies (2011) (29)
Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains. (1985) (29)
Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting. (1998) (29)
Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity. (2012) (29)
Cyclic AMP- and (Rp)-cAMPS-induced Conformational Changes in a Complex of the Catalytic and Regulatory (RIα) Subunits of Cyclic AMP-dependent Protein Kinase* (2010) (28)
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme (2015) (28)
Correlation of photolabeling with occupancy of cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. (1987) (28)
Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle (2019) (27)
Dissecting the cAMP‐inducible allosteric switch in protein kinase A RIα (2010) (27)
Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. (2019) (27)
Aminoacid sequence of dogfish M4 lactate dehydrogenase. (1973) (27)
Evolution of a dynamic molecular switch (2019) (27)
Molecular Features of Product Release for the PKA Catalytic Cycle (2014) (27)
Consequences of cAMP-binding site mutations on the structural stability of the type I regulatory subunit of cAMP-dependent protein kinase. (2000) (27)
Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50 (2017) (26)
Characterization of adenosine 3':5'-monophosphate-dependent protein kinase and its dissociated subunits from porcine skeletal muscle. (1978) (26)
Dissecting interdomain communication within cAPK regulatory subunit type IIβ using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS) (2003) (26)
Deletion mutants as probes for localizing regions of subunit interaction in cAMP-dependent protein kinase. (1988) (26)
Functional Malleability of the Carboxyl-terminal Tail in Protein Kinase A (1996) (26)
Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. (2010) (26)
Inhibition of the Mg(II).ATP-dependent phosphoprotein phosphatase by the regulatory subunit of cAMP-dependent protein kinase. (1985) (26)
Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20 (2013) (26)
Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. (2003) (26)
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor (2016) (25)
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. (2009) (25)
Identification of the Degradation Determinants of Insulin Receptor Substrate 1 for Signaling Cullin-RING E3 Ubiquitin Ligase 7-mediated Ubiquitination* (2012) (25)
Dynamic Binding of PKA Regulatory Subunit RIα (2006) (25)
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades (2021) (25)
Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers (2017) (25)
Kinase domain dimerization drives RIPK3-dependent necroptosis (2018) (25)
Bound to activate: conformational consequences of cyclin binding to CDK2. (1995) (25)
Covalent modification of both cAMP binding sites in cAMP-dependent protein kinase I by 8-azidoadenosine 3',5'-monophosphate. (1985) (24)
Binding-dependent disorder-order transition in PKI alpha: a fluorescence anisotropy study. (1999) (24)
Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase. (1997) (24)
Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. (2012) (24)
Catalytic subunit of cAMP-dependent protein kinase: electrostatic features and peptide recognition. (1998) (23)
cAMP-dependent protein kinase: a framework for a diverse family of enzymes. (1988) (23)
The Conformationally Dynamic C Helix of the RIα Subunit of Protein Kinase A Mediates Isoform-specific Domain Reorganization upon C Subunit Binding* (2005) (23)
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP (2006) (23)
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. (2020) (22)
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit. (2001) (22)
Dynamic allostery-based molecular workings of kinase:peptide complexes (2019) (22)
Mutations in the autoinhibitor site of the regulatory subunit of cAMP-dependent protein kinase I. Replacement of Ala-97 and Ser-99 interferes with reassociation with the catalytic subunit. (1991) (22)
Identification of electrostatic interaction sites between the regulatory and catalytic subunits of cyclic AMP‐dependent protein kinase (1997) (22)
Analogous regulatory sites within the αC-β4 loop regions of ZAP-70 tyrosine kinase and AGC kinases (2008) (22)
Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I. (1990) (22)
Tyrosine-371 contributes to the positive cooperativity between the two cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. (1988) (22)
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. (2004) (21)
Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. (2007) (21)
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma (2018) (21)
Endogenous protein kinase A inhibitor (PKIα) modulates synaptic activity (1998) (20)
A decade of molecular cell biology: achievements and challenges (2011) (20)
Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells (2018) (20)
Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα (2018) (20)
Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα (2015) (19)
Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer (2014) (19)
Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex (2019) (19)
Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family. (1993) (19)
C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. (2004) (19)
Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP (2019) (19)
Type II beta regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization. (2000) (19)
Inhibition of the catalytic subunit of cAMP-dependent protein kinase by dicyclohexylcarbodiimide. (1987) (18)
Cardiac ischemia/reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. (2019) (18)
Yet another “active” pseudokinase, Erb3 (2010) (18)
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2 (2020) (18)
Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A. (1988) (17)
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS (2019) (17)
R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. (2007) (17)
cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits (2018) (17)
Primary structure of acetylcholinesterase: implications for regulation and function. (1986) (17)
Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering* (2009) (17)
Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. (2016) (17)
Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. (2016) (17)
Selective modification of the catalytic subunit of cAMP-dependent protein kinase with sulfhydryl-specific fluorescent probes. (1989) (17)
Crystallization of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. (1991) (17)
Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases (2016) (16)
Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity (2009) (16)
Allosteric linkers in cAMP signalling. (2014) (16)
Probing the multidomain structure of the type I regulatory subunit of cAMP-dependent protein kinase using mutational analysis: role and environment of endogenous tryptophans. (2000) (16)
Intermolecular contacts in various crystal forms related to the open and closed conformational states of the catalytic subunit of cAMP-dependent protein kinase. (1994) (16)
Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. (2015) (16)
Structure of smAKAP and its regulation by PKA‐mediated phosphorylation (2016) (16)
Expression and mutagenesis of the regulatory subunit of cAMP-dependent protein kinase in Escherichia coli. (1988) (15)
Influence of N-Myristylation and Ligand Binding on the Flexibility of the Catalytic Subunit of Protein Kinase A (2013) (15)
Quantitative Proteomics Analysis of the cAMP/Protein Kinase A Signaling Pathway (2012) (15)
Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα. (2017) (15)
Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors (2015) (15)
Addition of functional human telomeres to YACs. (1994) (15)
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma (2020) (14)
The Fractalkine / CX 3 CR 1 System Regulates b Cell Function and Insulin Secretion (14)
Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase. (1993) (14)
Endogenous tryptophan residues of cAPK regulatory subunit type IIβ reveal local variations in environments and dynamics (2003) (14)
Limited proteolysis alters the photoaffinity labeling of adenosine 3',5'-monophosphate dependent protein kinase II with 8-azidoadenosine 3',5'-monophosphate. (1987) (14)
Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling (2021) (14)
The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. (2018) (13)
Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains (2019) (13)
Unfolding of the regulatory subunit of cAMP-dependent protein kinase I. (1991) (13)
Monoclonal antibodies as structural probes of surface residues in the regulatory subunit of cAMP-dependent protein kinase II from porcine heart. (1983) (13)
Discovery of Allostery in PKA Signaling (2015) (13)
Switching of the folding-energy landscape governs the allosteric activation of protein kinase A (2018) (13)
Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. (2015) (13)
The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B. (1969) (12)
Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function (2000) (12)
Imaging of cAMP signals and A-kinase translocation in single living cells. (1993) (12)
Dimerization/Docking Domain of the Type Iα Regulatory Subunit of cAMP-dependent Protein Kinase (1998) (12)
Identification and functional analysis of dual-specific A kinase-anchoring protein-2. (2004) (12)
Subunit of PKA : A cAMP-free Structure Reveals a Hydrophobic Capping Mechanism for Docking cAMP into Site (2004) (12)
Holoenzyme interaction sites in the cAMP-dependent protein kinase. Histidine 87 in the catalytic subunit complements serine 99 in the type I regulatory subunit. (1994) (12)
Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. (2008) (11)
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains (2022) (11)
Cyclic AMP-dependent protein kinase: purification of the holoenzyme by affinity chromatography. (1976) (11)
Allosteric pluripotency as revealed by protein kinase A. (2020) (11)
Comparison of the D-lactate stereospecific dehydrogenase of Limulus polyphemus with active-site regions of L-lactate dehydrogenases. (1983) (11)
Mammalian cAMP-dependent protein kinase functionally replaces its homolog in yeast. (1991) (11)
Optical Probes for Cyclic AMP (1999) (11)
Dynamic binding of PKA regulatory subunit RI alpha. (2006) (10)
Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A (2021) (10)
The amino acid sequence of the tryptic peptides isolated from dogfish M4 lactate dehydrogenase. (1975) (10)
Protein kinases share a common structural motif outside the conserved catalytic domain. (1994) (10)
A method for linking yeast artificial chromosomes. (1996) (10)
Crystal structure of a zinc‐containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 Å resolution (2002) (10)
Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery (2020) (10)
Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A* (2015) (9)
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies. (2021) (9)
D‐AKAP2:PKA RII:PDZK1 ternary complex structure: Insights from the nucleation of a polyvalent scaffold (2015) (9)
Protein kinases: coming of age (1992) (9)
Crystal structure of LRRK2 WD40 domain dimer (2019) (9)
Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system (2015) (9)
Induced interchain disulfide bonding in cAMP-dependent protein kinase II. (1984) (8)
Crystallization studies of the catalytic subunit of cAMP-dependent protein kinase: crystals of murine recombinant catalytic subunit and a mutant, Cys 343----Ser, diffract to 2.7 A resolution. (1992) (8)
Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes (2020) (8)
NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit (2006) (8)
Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A (2020) (8)
A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. (2018) (7)
Dissecting cAMP Binding Domain A in the RIα Subunit of cAMP-dependent Protein Kinase (1998) (7)
Allosteric pluripotency as revealed by protein kinase A (2020) (7)
Fluorescence energy transfer between cysteine 199 and cysteine 343: evidence for MgATP-dependent conformational change in the catalytic subunit of cAMP-dependent protein kinase. (1989) (7)
The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. (2011) (6)
Conformational Isomers of Calcineurin Follow Distinct Dissociation Pathways (2012) (6)
Monoclonal antibodies as probes of structure, function and isoenzyme forms of the type II regulatory subunit of cyclic AMP-dependent protein kinase. (1985) (6)
Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics. (2009) (6)
A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host (2022) (6)
Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Heterobifunctional cross-linking reagents lead to photodependent and photoindependent cross-linking. (1988) (6)
ReviewRegulation of Protein Kinases : Controlling Activity through (2004) (6)
Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. (2013) (5)
Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme (2012) (5)
Editorial overviewProtein kinases: Catalysis and regulation (2006) (5)
Affinity chromatography of lactate dehydrogenase. A biochemistry experiment (1978) (5)
REDOX REGULATION OF PKA SIGNALING : KINASE VERSUS PHOSPHATASE INACTIVATION (2007) (5)
Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PKAc alpha (2019) (5)
A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction (2021) (5)
Is disrupted nucleotide-substrate cooperativity a common trait for Cushing's syndrome driving mutations of protein kinase A? (2021) (5)
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations (2021) (4)
REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE (1996) (4)
[14] Affinity labeling of cAMP-dependent protein kinases (1983) (4)
The evolution of protein phosphorylation (2016) (4)
The tails of PKA. (2021) (4)
Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430 (3)
Crystallization and preliminary X-ray analysis of the unliganded recombinant catalytic subunit of cAMP-dependent protein kinase. (1998) (3)
Affinity labeling of cAMP-dependent protein kinases. (1983) (3)
Two PKA RI alpha holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP (2019) (3)
Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics. (2021) (3)
Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits (2021) (3)
Molecular-dynamics simulation methods for macromolecular crystallography (2022) (3)
PKA and the Structural Kinome (2017) (2)
The Roles of the RIIβ Linker and N-terminal Cyclic Nucleotide-binding Domain in Determining the Unique Structures of the Type IIβ Protein Kinase A (2014) (2)
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy (2022) (2)
Calculation of centralities in protein kinase A (2022) (2)
Isoform-specific Differences between the Type Ia and IIa Cyclic AMP-dependent Protein Kinase Anchoring Domains Revealed (2000) (2)
Dynamics of signalling by PKA (2005) (2)
Fractal Nature of Protein Interior and its Implications for Protein Function (2017) (2)
Carbodiimides as probes for protein kinase structure and function. (1991) (2)
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System (LB772) (2014) (2)
1 IDENTIFICATION OF CHCHD 3 AS A NOVEL SUBSTRATE OF PKA USING AN ANALOG-SENSITIVE CATALYTIC SUBUNIT (2007) (2)
Novel LRR-ROC motif that links the N- and C-terminal Domains in LRRK2 undergoes an order-disorder transition upon activation. (2023) (2)
Intramolecular C 2 Domain-Mediated Autoinhibition of Protein Kinase C b II Graphical Abstract Highlights (2015) (1)
Update on Stomatal Signaling Networks Calcium-Dependent and-Independent Stomatal Signaling Network and Compensatory Feedback Control of Stomatal Opening via Ca 2 + Sensitivity Priming [ W ] (2013) (1)
Active Site and Other Sequence Data from Torpedo Californica Acetylcholinesterase (1987) (1)
Expression and characterization of a truncated form of regulatory subunit of cAMP-dependent protein kinase I lacking binding domain A. (1990) (1)
PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling (2020) (1)
A Cushing Syndrome Mutation of Protein Kinase A C‐subunit Disrupts the Internal Allosteric Network Affecting Regulation and Substrate Specificity (2019) (1)
The relationship between structure and function in cAMP-dependent protein kinases. (1986) (1)
cAMP/PKA‐mediated regulation of amino acid metabolism in murine T‐lymphoma cells (1095.16) (2014) (1)
Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition (2021) (1)
PNAS Plus Significance Statements (2018) (1)
The Relationship between Structure and Function in AMP‐dependent Protein Kinases a (1986) (1)
Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase (2014) (1)
Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. (2018) (1)
exchange mass spectrometry ( DXMS ) subunit type IIß using enhanced amide hydrogen / deuterium Dissecting interdomain communication within cAPK regulatory (2003) (1)
Activation of a Protein Kinase Via Asymmetric Allosteric Coupling of Structurally Conserved Signaling Modules (2019) (1)
Protein Kinase Structure & Function: cAMP-Dependent Protein Kinase (1991) (1)
The in Vitro Phosphorylation of Chromatin by CAMP-dependent Protein Kinase * the Catalytic Subunit of (2001) (1)
Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers (2017) (1)
The crystal structure of a Protein Kinase A complex (2005) (1)
Correction for Kannan et al., The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module (2008) (1)
Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons. (2020) (1)
Sequence of selected peptides from torpedo californica acetylcholinesterase (1985) (1)
On the activation and regulation of the mg(ii)-atp-dependent protein phosphatase (1985) (1)
Global Consequences of Activation Loop Phosphorylation on (2010) (1)
Use of High Performance Liquid Chromatography in Characterizing Nucleotide Binding Sites and Antigenic Determinants in cAMP-Dependent Protein Kinase (1982) (1)
Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation (2005) (1)
Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation (2021) (1)
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition (2022) (1)
Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle (2019) (0)
Dynamic Disease Landscape of a Cancer Driving Fusion Kinase (2020) (0)
Functional and Structural Characterization of Acrodysostosis Mutations of PKA RIα Reveals Mechanism Causing resistant to cAMP activation (2020) (0)
Catalytic Subunit of CAMP-Dependent Protein Kinase : Electrostatic Features and 9500 (2002) (0)
Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors (2022) (0)
Lawrence Berkeley National Laboratory Title The Sorcerer II Global Ocean Sampling Expedition : Expanding the Universe of Protein Families Permalink (2007) (0)
The mitochondrial targeting form of PKA anchoring protein D‐AKAP1a may affect the structure of mitochondria cristae and the function of mitochondria (2007) (0)
NMR Mapping of the Allosteric Network in the Oncogenic Protein Kinase A Chimera Dnajb1‐PRKACA (2017) (0)
Conformational and Shape Changes Associated with cAMP- Dependent Protein Kinase (1991) (0)
Phosphorylation of PKA Regulatory Subunit RIα by PKG: a Mechanism for “Desensitizing” the Type I PKA Holoenzyme (2016) (0)
Development of Synthetic Biologics to Probe the Role of D‐AKAP2 in Breast Cancer (2011) (0)
Structural features that define specificity for camp and cgmp (1996) (0)
Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog (2013) (0)
Molecular Dynamics Simulation and Markov State Model Reveal Irregular Metastable Conformation and Allostery In DNAJB-PKAc (2016) (0)
, Lalima RAF Kinases and Pseudokinases : Lessons from (2014) (0)
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration (2023) (0)
Theoretical model of RET protein kinase complexed with ATP based on the insulin receptor tyrosine protein kinase X-ray structure (2006) (0)
Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase (2009) (0)
Do perineuronal nets stabilize the engram of a synaptic circuit? (2023) (0)
Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase (2004) (0)
Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase (2007) (0)
Architecture of the PKA RIIβ Holoenzyme (2009) (0)
Camp-dependent protein kinase: Structural basis for subcellular localization (1998) (0)
Architecture of the PKA RII{beta} Holoenzyme (2009) (0)
conformations cAMP-dependent protein kinase reveal open and closed Crystal structures of the myristylated catalytic subunit of data (2002) (0)
Abstract 4142: Conformational dynamics of the chimeric kinase DNAJB1-PRKACA, the driver for fibrolamellar hepatocellular carcinoma (2018) (0)
Subcellular localization of PKA catalytic subunits provides a basis for their distinct functions in the retina (2021) (0)
AKIP1 protects against cardiac injury via enhanced mitochondrial function (2013) (0)
Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA (2010) (0)
The Regulatory Subunit Type Iα of Protein Kinase A: A Study of Carney Complex and Acrodysostosis Mutations (2017) (0)
vivo myocardial ischemia-reperfusion injury receptor-mediated Akt activation protects against in Sphingosine 1-phosphate S 1 P 2 and S 1 P 3 (2007) (0)
intermyofibrillar mitochondrial proteins and alterations in cardiac subsarcolemmal and Exercise training induces a cardioprotective phenotype (2011) (0)
Gαs (GNAS) suppression of the p53 genomic‐stability checkpoint unleashes RAS‐driven oncogenesis (2020) (0)
Single turnover and pre-steady-state kinetics for RIIβ holoenzyme phosphorylation in the presence of Mg 2+ versus Ca 2+ . (2015) (0)
Structure of D‐AKAP2‐PKA RI isoform complex: Insights into AKAP specificity and selectivity (2010) (0)
Understanding the role of the LRRK2 tail in the crosstalk between kinase and the N-terminal domains. (2023) (0)
Protein Kinases: Phosphorylation Machines (2011) (0)
Dynamic architecture of a protein kinase (802.22) (2014) (0)
Disulfide bonds of acetylcholinesterase (1986) (0)
Structural and Biochemical Basis for the Dynamic Malleability and Cooperative Activation of PKA-Ia Holoenzyme (2007) (0)
PKA: assembly of dynamic macromolecular signaling (2011) (0)
Direct PKA‐PDE interactions lead to localized cAMP signaling domains in adult cardiomyocytes (1013.7) (2014) (0)
Dynamics of PKA Signaling (2010) (0)
PKA RIIbeta holoenzyme with DnaJB1-PKAc fusion in fibrolamellar hepatoceullar carcinoma (2020) (0)
Crystallization of PKA regulatory subunit from Saccharomyces cerevisiae (2008) (0)
Conformational landscape of the protein kinase A Inhibitor PKI studied by fluorescence and NMR spectroscopy (2017) (0)
Novel Responsibilities for PKA Regulatory Subunits: Regulating Cell Migration through the Assembly of a P‐Rex1‐based Signaling Platform (2017) (0)
D‐AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin recycling (2009) (0)
Protein Kinase A isoform dynamics and disease. (2020) (0)
An Allosteric Region of Src Tyrosine Kinase Allows for Stabilization of Its Active-Like Conformation (2018) (0)
Decision letter: AKAP79 enables calcineurin to directly suppress protein kinase A activity (2021) (0)
Apo structure of the catalytic subunit of cAMP-dependent protein kinase (2014) (0)
Conformations of P90 Ribosomal S6 Kinase Activation (2020) (0)
substrate recognition and phosphotransfer cAMP-dependent protein kinase : Crystallographic insights into data (2002) (0)
The structure of LRRK2 and the conformational changes that are associated with LRRK2 activation and Parkinson’s disease pathogenesis (2020) (0)
Correction: A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains (2009) (0)
The first crystal structure of cyclic GMP‐dependent protein kinase Iβ dimerization domain reveals the molecular features of an extended leucine/isoleucine zipper (2008) (0)
High Affinity Binding of the Heat-stable Protein Kinase Inhibitor to the Catalytic Subunit of CAMP-dependent Protein Kinase Is (1994) (0)
Crystal structures of the RIIβ holoenzyme showing active site phosphorylation in the presence of calcium. (2015) (0)
Crystal Structure of phospholamban (1-19):PKA C-subunit:AMP-PNP:Mg2+ complex (2010) (0)
Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA (2017) (0)
cAMP-dependent protein kinase: dynamics of catalysis and docking (2003) (0)
Fifty Years Since the Discovery of PKA (2002) (0)
Structural studies of the dimerization/docking domain of the type la regulatory subunit of PKA (1997) (0)
Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent (2001) (0)
PKA: Dynamic Assembly and Regulation of Macromolecular Signaling Complexes (2017) (0)
My Journey with cAMP‐dependent Protein Kinase (2022) (0)
Assembly of Protein Kinase a RIIβ Macromolecular Complexes (2014) (0)
Author response: Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A (2020) (0)
Characterization of chchd3; A novel cAMP dependent protein kinase A substrate in mitochondria (2007) (0)
Proteomic analysis of the cAMP/protein kinase A (PKA) signaling pathway identifies PKA as a regulator of cellular response to oxidative stress (2013) (0)
NMR Structural/Functional Characterization of an Oncogenic Mutant of cAMP-Dependent Protein Kinase A: PRKACA-DNAJB1 (2016) (0)
Endogenous RIIβ is constitutionally phosphorylated in 3T3 and HeLa cells. (2015) (0)
Site-specific mutations in the regulatory subunit of cAMP-dependent protein kinase: selective screening for functional cAMP binding sites. [Escherichia coli] (1987) (0)
CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE (2001) (0)
Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog (2013) (0)
IL-3-Induced Phosphorylation of BAD Through a Membrane-Targeted cAMP-Dependent Protein Kinase (1998) (0)
PKA RIα Holoenzyme Structure Reveals ATP‐Dependent Dynamics and Allosteric Regulation in Isoform‐Specific Manner (2020) (0)
Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A (2021) (0)
The crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding - eScholarship (2011) (0)
DIVElRSE FAMILY OF REGULATORY ENZy'MES (1990) (0)
An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A (2023) (0)
Corrigendum: Dynamics connect substrate recognition to catalysis in protein kinase A (2011) (0)
Contributory presentations/posters (1999) (0)
Crystal Structure of the full-length wild-type PKA RIa Holoenzyme (2019) (0)
Discovery of allostery in PKA signaling (2015) (0)
Two PKA RIA Holoenzyme Structural States Define ATP as an Isoform Specific Orthosteric Inhibitor that Competes with Allosteric Activator, ATP (2020) (0)
Dynamic expression and localization of Protein Kinase A regulatory subunit RIα in cardiac mitochondria controls response to oxidative stress (2013) (0)
Crystal Structure of Full-Length PKA Rib: Insights Into Novel Isoform Specificity of Tetrameric Holoenzyme Assembly (2012) (0)
Non‐canonical Recruitment of PKA Catalytic Subunits to RIα‐driven Biomolecular Condensates (2022) (0)
Protein kinases/signal transduction: structure/function (2006) (0)
Binding-Dependent Disorder-Order Transition in PKIR: A Fluorescence (1999) (0)
Dysfunctional PKA Drives Diverse Disease Phenotypes (2016) (0)
Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit (2003) (0)
Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A (2021) (0)
Holoenzyme Interaction Sites in the CAMP-dependent (1994) (0)
Fusion Protein, DNAJB1-PRKACA, as a Cancer Driver (2017) (0)
extended N-terminal A helix kinase reveals an unexpected apoenzyme conformation and an Crystal structure of the E 230 Q mutant of cAMP-dependent protein (2005) (0)
Quaternary architecture of PKA RIβ holoenzyme reveals isoform diversity (802.5) (2014) (0)
Crystal structure of dual-specific A-kinase anchoring protein 2 in complex with cAMP-dependent protein kinase A type II alpha and PDZK1 (2012) (0)
Binary complex of metal-free PKAc with SP20. (2014) (0)
A tribute to Eddy Fischer (April 6, 1920–August 27, 2021): Passionate biochemist and mentor (2022) (0)
Product complex of metal-free PKAc, ATP-gamma-S and SP20. (2014) (0)
Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase (2008) (0)
Crystal structure of PKA RI alpha dimerization/docking domain (2010) (0)
Noncanonical PDZ Interaction between PKA RIα R368X Acrodysostosis Mutant and P‐Rex1 PDZ Domain (2016) (0)
Determination of analytes by transfer of fluorescent energy (1991) (0)
ISOFORM-SPECIFIC DIFFERENCES BETWEEN THE TYPE I AND II PKA ANCHORING DOMAINS REVEALED BY SOLUTION NMR (2000) (0)
Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2 (2004) (0)
vivo models failure-associated genes by combining in vitro and in Identification of hypertrophy- and heart (2015) (0)
Crystal Structure of cAMP bound (91-244)RIa Subunit of cAMP-dependent Protein Kinase (2010) (0)
Intramolecular C2‐Kinase Domain Interactions Autoinhibit Conventional Protein Kinase (2016) (0)
Joint X-ray/neutron structure of PKAc with products Sr2-ADP and phosphorylated peptide SP20 (2019) (0)
Dynamics of the PKA C-Subunit Major Conformational States Using REXAMD (2010) (0)
Non-Classical Protein Kinase a Activation by Aggregation of the PKA R-Subunits as a Mechanism of Inherited Carney Complex Mutations (2021) (0)
The Amino Acid Sequence of the Tryptic Peptides Isolated from Dogfish M , Lactate Dehydrogenase * (2002) (0)
cAMP-dependent protein kinase catalytic subunit Examination of an active-site electrostatic node in the References (2002) (0)
NEUTRON SCATTERING STUDY A : A SMALL ANGLE X-RAY AND Protein Kinase β Structures of the Type II Domain in Determining the Unique N-terminal Cyclic Nucleotide-binding Linker and β The Roles of the RII Protein Structure and Folding (2014) (0)
Crystal structure of myristoylated K7C catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP (2012) (0)
Significance of activation loop phosphorylation in protein kinase A studied by H/D exchange and X‐ray crystallography (2009) (0)
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma (2018) (0)
The first crystal structure of cyclic GMP-dependent protein kinase Iβ dimerization/docking domain reveals molecular details of isoform-specific anchoring (2009) (0)
Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 (2010) (0)
Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase (2011) (0)
Aminoacid Sequence of Dogfish M4 Lactate Dehydrogenase (glyceraldehyde-3-phosphate dehydrogenase/lactic acid yeast and liver alcohol dehydrogenases) (0)
Crystal structure of cAMP-free R1a subunit of PKA (2004) (0)
Crystal structure of R336A mutant of cAMP-dependent protein kinase with unphosphorylated turn motif. (2013) (0)
Model for Protein Kinase A Type RI{alpha} Tetrameric Holoenzyme (2010) (0)
Conserved hydrophobic ensembles in protein kinases: their integrating and regulatory roles (2008) (0)
Cyclic AMP/PKA‐Mediated Regulation of Mitochondria and Branched‐Chain Amino Acid Metabolism in S49 Lymphoma Cells (2015) (0)
Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent (2001) (0)
Crystal structure of a complex between the catalytic and regulatory (RI alpha 91‐379) subunits of PKA (2006) (0)
PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genes (2020) (0)
PKA Type IIa Holoenzyme Structure Reveals Isoform Diversity for Inhibition of Catalysis (2008) (0)
The RGS homology domains of D‐AKAP2 regulate the endocytic recycling compartment through complexes with Rab4 and Rab11 (2008) (0)
AKIP1, PKA, and AIF: Human Embryonic Stem Cells Dance Towards Death (2007) (0)
Elucidating the Mechanism of Recognition and Binding of Protein Kinase Inhibitor by Protein Kinase a using NMR and Fluorescence Spectroscopy (2016) (0)
The in Situ structure of a Parkinson's Disease Mutant LRRK2 Bound to Cellular Microtubules Revealed by Cryo-electron Tomography (2020) (0)
The Forgotten PKAs: New Insights Revealed by the First Crystal Structure of a PKA C Beta Splice Variant, Cβ4ab (2022) (0)
The "violin model": Looking at community networks for dynamic allostery. (2023) (0)
Isoform‐specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A (690.13) (2014) (0)
Model for Protein Kinase A Type RIα Tetrameric Holoenzyme (2010) (0)
IZING NUCLEOTIDE BINDING SITES AND ANTIGENIC DETERMINANTS IN (1982) (0)
Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 (2020) (0)
The splice variants of D-AKAP1 differ in subcellular localization and tissue-specific expression (1997) (0)
subdomains at the cleft interface cAMP-dependent protein kinase for stability and for orienting Importance of the A-helix of the catalytic subunit of (2002) (0)
SP 04 Understanding the dynamics of " Pseudokinase " mutations (2018) (0)
Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop (2012) (0)
Ret Receptor: Functional Consequences of Oncogenic Rearrangements. (1996) (0)
Uncoupling Catalytic and Binding Functions in the cAMP-Dependent Protein Kinase A (2016) (0)
Protein-Ligand Interactions through the Computational Microscope: Allostery in a Canonical Signaling Domain (2016) (0)
Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8 (2004) (0)
Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase (2004) (0)
MOLECULAR ASPECTS OF THE BIOSYNTHESIS AND DISPOSITION OF THE MULTIPLE FORMS OF ACETYLCHOLINESTERASE (1984) (0)
cAMP-Dependent Protein Kinase: Mechanism for ATP:Protein Phosphotransfer (2018) (0)
The Tails of Protein Kinase A (2022) (0)
Single Molecule Analysis of Allosteric Interactions in Protein Kinase A (2016) (0)
cAMP-dependent protein kinase: structural basis for function, regulation, and subcellular localization (1998) (0)
A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state (2007) (0)
Crystal structure of smAKAP AKB domain bound RIa dimerization/docking (D/D) complex at 2.0 A resolution (2016) (0)
X-ray structure of PKAc with ADP, free phosphate ion, CP20, magnesium ions (2015) (0)
Two helices control the dynamic crosstalk between the catalytic domains of LRRK2 (2021) (0)
Structure of the catalytic subunit of cAMP-dependent protein kinase bound to ADP and one magnesium ion (2014) (0)
Subcellular Localization and Functional Characterization of cAMP‐dependent Protein Kinase A Isoforms: Painting Specificity by Mosaic Brain Mapping (2017) (0)
Protein kinase structure, function and regulation (2010) (0)
X-ray structure of PKAc with AMPPNP, SP20, calcium ions (2015) (0)
Structural Studies and Dynamics of p90 Ribosomal S6 Kinase (RSK) (2021) (0)
Crystallographic Studies of the Catalytic Subunit of cAMP- Dependent Protein Kinase (1991) (0)
CHAPTER 199 – cAMP-dependent Protein Kinase (2003) (0)
1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
Lessons Learned from PKA: from Motifs to the Dynamic Assembly of Isoform‐specific Macromolecular Switches (2017) (0)
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide (2013) (0)
Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PRKAc alpha (2019) (0)
and protein kinase A by cyclic AMP A simple electrostatic switch important in the activation of type I (2005) (0)
Structural and Dynamic Effects of Phosphorylation of Protein Kinase a Catalytic Subunit (2020) (0)
Crystal Structure of PKA RIalpha Homodimer (2014) (0)
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A (2023) (0)
Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses (2021) (0)

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