Susumu Seino
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Susumu Seino's Degrees
- PhD Biochemistry University of Tokyo
- Masters Molecular Biology University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Susumu Seino's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Reconstitution of IKATP: An Inward Rectifier Subunit Plus the Sulfonylurea Receptor (1995) (1764)
- A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels (1996) (976)
- Molecular Biology of Mammalian Glucose Transporters (1990) (846)
- PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005) (562)
- ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis (2001) (526)
- ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. (1999) (513)
- cAMP-GEFII is a direct target of cAMP in regulated exocytosis (2000) (501)
- Physiological and pathophysiological roles of ATP-sensitive K+ channels. (2003) (490)
- Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. (1989) (435)
- GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure (2013) (409)
- Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart (*) (1995) (405)
- Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP (2007) (403)
- Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. (2002) (389)
- International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels (2003) (386)
- Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion* (2001) (382)
- Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice (2002) (377)
- Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1 (2002) (364)
- Protective Role of ATP-Sensitive Potassium Channels in Hypoxia-Induced Generalized Seizure (2001) (343)
- Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (1990) (341)
- Dynamics of insulin secretion and the clinical implications for obesity and diabetes. (2011) (330)
- Kir6.2 is required for adaptation to stress (2002) (304)
- Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. (1993) (281)
- Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem (2001) (278)
- K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons (2005) (270)
- Subunit stoichiometry of the pancreatic β‐cell ATP‐sensitive K+ channel (1997) (269)
- International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels (2005) (268)
- Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. (1998) (261)
- Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. (2005) (260)
- GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. (2010) (258)
- The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. (2001) (253)
- Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. (1994) (246)
- PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. (2012) (238)
- A Nonsense Mutation in the Inward Rectifier Potassium Channel Gene, Kir6.2, Is Associated With Familial Hyperinsulinism (1997) (233)
- Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor. (1997) (228)
- β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians (2015) (227)
- The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs (2009) (221)
- Expression and role of ionotropic glutamate receptors in pancreatic islet cells (1995) (207)
- Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. (2002) (202)
- Functional Roles of Cardiac and Vascular ATP-Sensitive Potassium Channels Clarified by Kir6.2-Knockout Mice (2001) (199)
- Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. (2002) (191)
- K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration (2012) (185)
- PKA‐mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation (1999) (183)
- MgADP Antagonism to Mg2+-independent ATP Binding of the Sulfonylurea Receptor SUR1* (1997) (174)
- Molecular Basis of Electrocardiographic ST-Segment Elevation (2000) (174)
- Cblb is a major susceptibility gene for rat type 1 diabetes mellitus (2002) (173)
- Interaction of ATP Sensor, cAMP Sensor, Ca2+ Sensor, and Voltage-dependent Ca2+ Channel in Insulin Granule Exocytosis* (2004) (172)
- KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation (2007) (168)
- Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria. (1997) (163)
- Roles of KATP channels as metabolic sensors in acute metabolic changes. (2005) (160)
- Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide. (1999) (153)
- LKB1 regulates pancreatic beta cell size, polarity, and function. (2009) (153)
- Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice. (2000) (145)
- Identification and Characterization of Glucoresponsive Neurons in the Enteric Nervous System (1999) (145)
- Androgen receptor gene mutations in human prostate cancer (1993) (141)
- Characterization and Expression of Human HepG2/Erythrocyte Glucose-Transporter Gene (1988) (141)
- Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. (1994) (140)
- Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. (2003) (138)
- Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion (2014) (132)
- Mammalian glucose transporters: structure and molecular regulation. (1991) (128)
- The Na+-driven Cl−/HCO3 −Exchanger (2000) (127)
- Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines. (2000) (124)
- Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea (2012) (120)
- Sequence Variants in the Pancreatic Islet β-Cell Inwardly Rectifying K+ Channel Kir6.2 (Bir) Gene: Identification and Lack of Role in Caucasian Patients with NIDDM (1997) (119)
- Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. (2005) (119)
- Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6. (1994) (118)
- Roles of cAMP signalling in insulin granule exocytosis (2009) (116)
- Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. (2004) (116)
- MTABC3, a Novel Mitochondrial ATP-binding Cassette Protein Involved in Iron Homeostasis* 210 (2000) (112)
- Protection conferred by myocardial ATP‐sensitive K+ channels in pressure overload‐induced congestive heart failure revealed in KCNJ11 Kir6.2‐null mutant (2006) (112)
- Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+ Channel by 8-Azido-ATP* (1999) (107)
- KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. (2006) (105)
- Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K+ channels. (2004) (104)
- Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat (1995) (104)
- ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. (2004) (104)
- Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion (1993) (104)
- Human Insulin-Receptor Gene: Partial Sequence and Amplification of Exons by Polymerase Chain Reaction (1990) (101)
- Phospholipase C activation and Ca2+ mobilization by cloned human somatostatin receptor subtypes 1–5, in transfected COS‐7 cells (1994) (100)
- Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. (1996) (100)
- Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels. (2006) (98)
- ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. (2002) (94)
- Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects (2006) (93)
- Rim2alpha determines docking and priming states in insulin granule exocytosis. (2010) (93)
- Human Insulin-Receptor Gene (1990) (92)
- Critical role of the N‐terminal cyclic AMP‐binding domain of Epac2 in its subcellular localization and function (2009) (90)
- Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes. (2011) (85)
- Subunit stoichiometry of the pancreatic beta-cell ATP-sensitive K+ channel. (1997) (85)
- Localization of the ATP-Sensitive K+ Channel Subunit Kir6.2 in Mouse Pancreas (1997) (84)
- Cardioprotective Effect of Diazoxide Is Mediated by Activation of Sarcolemmal but Not Mitochondrial ATP-Sensitive Potassium Channels in Mice (2003) (83)
- Embryonic Stem Cell Therapy of Heart Failure in Genetic Cardiomyopathy (2008) (83)
- Noc2, a Putative Zinc Finger Protein Involved in Exocytosis in Endocrine Cells* (1997) (82)
- Gene knockout of the KCNJ8‐encoded Kir6.1 KATP channel imparts fatal susceptibility to endotoxemia (2006) (81)
- Isx Participates in the Maintenance of Vitamin A Metabolism by Regulation of β-Carotene 15,15′-Monooxygenase (Bcmo1) Expression* (2008) (76)
- The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. (2001) (76)
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (2004) (76)
- Role of Osteoglycin in the Linkage between Muscle and Bone* (2012) (76)
- Abnormalities of the adenomatous polyposis coli gene in human oral squamous‐cell carcinoma (1994) (76)
- A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat (2013) (74)
- cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8). (1995) (74)
- KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle. (2003) (73)
- An exonic point mutation of the androgen receptor gene in a family with complete androgen insensitivity. (1990) (73)
- Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. (2004) (72)
- Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2. (2009) (72)
- Gene targeting approach to clarification of ion channel function: studies of Kir6.x null mice (2004) (71)
- Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial (2015) (71)
- Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells. (1995) (71)
- S20G mutation of the amylin gene is associated with Type II diabetes in Japanese (2001) (70)
- A K(ATP) channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle. (2000) (70)
- KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart. (2007) (69)
- Treating diabetes today: a matter of selectivity of sulphonylureas (2012) (65)
- Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans. (2011) (62)
- Expression and complex formation of soluble N-ethyl-maleimide-sensitive factor attachment protein (SNAP) receptors in clonal rat endocrine cells (1995) (62)
- Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis. (2004) (61)
- Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway* (2011) (61)
- Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. (2001) (61)
- Localization and Functional Role of Synaptotagmin III in Insulin Secretory Vesicles in Pancreatic β-Cells (1997) (60)
- Essential Role of Ubiquitin-Proteasome System in Normal Regulation of Insulin Secretion* (2006) (60)
- Immuno-localization of sulphonylurea receptor 1 in rat pancreas (1999) (56)
- SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver (2013) (56)
- ATP-sensitive potassium channels: structures, functions, and pathophysiology. (1998) (55)
- Possible role of PEPT1 in gastrointestinal hormone secretion. (2005) (55)
- Human GLUT4/Muscle-Fat Glucose-Transporter Gene: Characterization and Genetic Variation (1992) (54)
- Somatostatin receptor subtype SSTR2 mediates the inhibition of high‐voltage‐activated calcium channels by somatostatin and its analogue SMS 201‐995 (1994) (54)
- Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. (2000) (53)
- Expression of GLUT1 and GLUT2 Glucose Transporter Isoforms in Rat Islets of Langerhans and Their Regulation by Glucose (1992) (53)
- Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2. (1995) (52)
- Liraglutide Improves Pancreatic Beta Cell Mass and Function in Alloxan-Induced Diabetic Mice (2015) (52)
- Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis (2009) (51)
- Modulation of reconstituted ATP‐sensitive K+ channels by GTP‐binding proteins in a mammalian cell line (1998) (50)
- Inositol 1,4,5-trisphosphate receptors, secretory granules and secretion in endocrine and neuroendocrine cells (1995) (50)
- Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion (2014) (49)
- Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1 (2011) (48)
- Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion* (2013) (48)
- Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes. (2007) (48)
- PDX-1 Protein is Internalized by Lipid Raft-Dependent Macropinocytosis (2005) (47)
- Treadmill running causes significant fiber damage in skeletal muscle of KATP channel-deficient mice. (2005) (46)
- Molecular biology of the β-cell ATP-sensitive K^+ channel (1996) (46)
- Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c (2015) (46)
- Role of Cadherin-mediated Cell-Cell Adhesion in Pancreatic Exocrine-to-Endocrine Transdifferentiation*♦ (2008) (45)
- Establishment of new clonal pancreatic β‐cell lines (MIN6‐K) useful for study of incretin/cyclic adenosine monophosphate signaling (2010) (44)
- Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A (2013) (44)
- Cellular distribution of the P2X4 ATP receptor mRNA in the brain and non-neuronal organs of rats. (1996) (44)
- β‐Cell signalling and insulin secretagogues: A path for improved diabetes therapy (2017) (42)
- Proteomic profiling of KATP channel‐deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome (2009) (40)
- DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice. (2012) (40)
- Somatostatin-like Immunoreactivity in Human Peripheral Plasma Measured by Radioimmunoassay Following Affinity Chromatography (1981) (39)
- Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin. (1997) (39)
- Cooperation between cAMP signalling and sulfonylurea in insulin secretion (2014) (38)
- Identification of Microsatellite Markers Near the Human Genes Encoding the β-cell ATP-Sensitive K+ Channel and Linkage Studies with NIDDM in Japanese (1996) (38)
- Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. (2004) (37)
- Structure and functional roles of Epac2 (Rapgef4). (2016) (37)
- A novel system that reports the G‐proteins linked to a given receptor: a study of type 3 somatostatin receptor (1997) (37)
- Smad7 inhibits differentiation and mineralization of mouse osteoblastic cells. (2012) (36)
- FAM5C is a soluble osteoblast differentiation factor linking muscle to bone. (2012) (36)
- Role of ATP-sensitive K+ channels in electrophysiological alterations during myocardial ischemia: a study using Kir6.2-null mice. (2005) (36)
- Arsenic exposure induces glucose intolerance and alters global energy metabolism. (2018) (36)
- Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome (2018) (36)
- Angiopoietin‐3, a novel member of the angiopoietin family (1999) (35)
- Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes. (2013) (35)
- The Na+-driven Cl-/HCO3 − exchanger: cloning, tissue distribution, and functional characterization. J Biol Chem (2000) (34)
- KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. (2014) (34)
- Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion (2014) (34)
- Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells. (2012) (34)
- Pancreatic beta cell in health and disease (2008) (34)
- Physiology and pathophysiology of K(ATP) channels in the pancreas and cardiovascular system: a review. (2003) (34)
- Pancreatic acinar-to-beta cell transdifferentiation in vitro. (2008) (33)
- Reduced levels of messenger ribonucleic acid for calcium channel, glucose transporter-2, and glucokinase are associated with alterations in insulin secretion in fasted rats. (1994) (31)
- Insulin secretion and computed tomography values of the pancreas in the early stage of the development of diabetes (2012) (31)
- Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat (2007) (31)
- Direct Inhibition of the Interaction between α-Interaction Domain and β-Interaction Domain of Voltage-dependent Ca2+ Channels by Gem* (2005) (31)
- Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes. (2020) (30)
- PACAP/VIP Receptors in Pancreatic β‐Cells: Their Roles in Insulin Secretion a (1996) (29)
- Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients (2008) (29)
- Role of sarcolemmal ATP‐sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2‐deficient mice (2008) (28)
- Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells. (1994) (27)
- Identification, Tissue Expression, and Functional Characterization of Otx3, a Novel Member of the Otx Family* (2002) (27)
- Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers (2018) (27)
- Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. (2006) (26)
- Effects of insulin degludec and insulin glargine on day-to-day fasting plasma glucose variability in individuals with type 1 diabetes: a multicentre, randomised, crossover study (2015) (25)
- Effects of DPP‐4 inhibitor linagliptin and GLP‐1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes: A randomized, open‐label, 2‐arm parallel comparative, exploratory trial (2016) (25)
- Pancreatic β-cell signaling: toward better understanding of diabetes and its treatment (2010) (25)
- Pancreatic β-cells are generated by neogenesis from non-β-cells after birth. (2011) (25)
- Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family (1993) (25)
- Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes (2015) (24)
- Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity. (1999) (23)
- Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (23)
- Identification and functional analysis of CBLB mutations in type 1 diabetes. (2008) (23)
- C-peptide response to glucagon challenge is correlated with improvement of early insulin secretion by liraglutide treatment. (2012) (23)
- Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance (2016) (22)
- Cephalic phase insulin secretion is KATP channel independent. (2013) (22)
- Sulfonylurea action re‐revisited (2010) (22)
- Identification of Histone H2A.X as a Growth Factor Secreted by an Androgen-independent Subline of Mouse Mammary Carcinoma Cells* (1996) (22)
- Alendronate induces mineralization in mouse osteoblastic MC3T3-E1 cells: regulation of mineralization-related genes. (2010) (22)
- Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets. (2015) (22)
- Polymorphic variation in the CBLB gene in human type 1 diabetes (2004) (20)
- Glutamate as intracellular and extracellular signals in pancreatic islet functions (2019) (20)
- Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat. (2008) (20)
- Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic β-Cells in Kir6.2G132S Transgenic Mice (2006) (20)
- ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling. (2003) (19)
- Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans. (2012) (19)
- Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K+ channels (2015) (18)
- Normalization of Intracellular Ca2+ Induces a Glucose-responsive State in Glucose-unresponsive β-Cells* (2002) (18)
- Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion (2017) (17)
- Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem. (2005) (17)
- What ails the β‐cell? (2010) (17)
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity (2021) (17)
- Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain. (2003) (16)
- PACAP/VIP receptors in pancreatic beta-cells: their roles in insulin secretion. (1996) (16)
- Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity (2015) (16)
- Diurnal variation of carbohydrate insulin ratio in adult type 1 diabetic patients treated with continuous subcutaneous insulin infusion (2013) (16)
- Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (16)
- Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. (2008) (16)
- Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2 (1996) (16)
- Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats (2010) (15)
- Age‐dependent decline in β‐cell function assessed by an oral glucose tolerance test‐based disposition index (2011) (15)
- Current status of regeneration of pancreatic β‐cells (2013) (15)
- Severe hypophosphatemic osteomalacia with Fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis. (2009) (15)
- BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis (2014) (14)
- Inhibition of ATP-sensitive K+ channels and L-type Ca2+ channels by amiodarone elicits contradictory effect on insulin secretion in MIN6 cells. (2011) (14)
- Characterization of genes encoding the pancreatic beta-cell ATP-sensitive K+ channel in persistent hyperinsulinemic hypoglycemia of infancy in Japanese patients. (2000) (14)
- Dmbx1 is essential in agouti-related protein action (2007) (14)
- Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas (2015) (14)
- Piccolo, a Ca2+ Sensor in Pancreatic β-Cells (2002) (13)
- Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats (2011) (13)
- Molecular basis of functional diversity of ATP-sensitive K+ channels. (1997) (13)
- Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells (2019) (13)
- β‐Cell glutamate signaling: Its role in incretin‐induced insulin secretion (2016) (13)
- Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat (2015) (13)
- Long in the shade, glucagon re‐occupies centre court (2011) (12)
- Braving the Element: Pancreatic β-Cell Dysfunction and Adaptation in Response to Arsenic Exposure (2019) (12)
- CACN4, the major α1 subunit isoform of voltage-dependent calcium channels in pancreatic β-cells: a minireview of current progress (1995) (12)
- The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B4 axis (2020) (12)
- A Novel Function of Noc2 in Agonist-Induced Intracellular Ca2+ Increase during Zymogen-Granule Exocytosis in Pancreatic Acinar Cells (2012) (11)
- The sodium driven chloride bicarbonate exchanger: Cloning, tissue distribution, and functional characterization (2000) (11)
- Induction by NeuroD of the components required for regulated exocytosis. (2007) (11)
- Functional analysis of transcriptional repressor Otx3/Dmbx1 (2005) (10)
- Menin interacts with β-catenin in osteoblast differentiation. (2011) (10)
- Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. (2004) (10)
- Glutamate is an essential mediator in glutamine‐amplified insulin secretion (2021) (10)
- Disruption of Kir6.2‐containing ATP‐sensitive potassium channels impairs maintenance of hypoxic gasping in mice (2007) (10)
- GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. (2020) (10)
- Rat neurological disease creeping is caused by a mutation in the reelin gene. (2003) (10)
- Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus (2018) (9)
- Structure and Function of ATP-Sensitive K+ Channels (2000) (9)
- Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse (2006) (9)
- Inhibition of SNAT5 Induces Incretin-Responsive State From Incretin-Unresponsive State in Pancreatic β-Cells: Study of β-Cell Spheroid Clusters as a Model (2018) (8)
- Integration of ATP, cAMP, and Ca 2 Signals in Insulin (2004) (8)
- Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. (2004) (8)
- Glucose regulation of arginine-induced pancreatic somatostatin release from the isolated perfused rat pancreas (1982) (8)
- Physical and functional interaction of noc2/rab3 in exocytosis. (2005) (8)
- Increased glycolysis affects β-cell function and identity in aging and diabetes (2021) (8)
- Correlation of serum CPR to plasma glucose ratio with various indices of insulin secretion and diseases duration in type 2 diabetes. (2013) (7)
- Normalization of intracellular Ca(2+) induces a glucose-responsive state in glucose-unresponsive beta-cells. (2002) (7)
- Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. (2004) (7)
- Chapter 20 Structure and Function of ATP-Sensitive Potassium Channels (1999) (7)
- 各種臓器のATP感受性K+チャネルの構造と機能：薬物制御によるQOLの向上をめざして (2003) (6)
- The hyperstimulated β‐cell: prelude to diabetes? (2012) (6)
- Restriction fragment length polymorphism (RFLP) of the human insulin receptor gene in Japanese: its possible usefulness as a genetic marker (1986) (6)
- Expression of uKATP-1 (Kir6.1) in neonatal rat kidney proximal tubule. (1997) (6)
- Functional adenosine triphosphate‐sensitive potassium channel is required in high‐carbohydrate diet‐induced increase in β‐cell mass (2018) (6)
- Increase in liver glucose transporter mRNA levels during rat liver regeneration. (1990) (6)
- A Monitor of Secretion From Single Pancreatic β-Cells (1995) (6)
- In vitro generation of insulin‐secreting cells from human pancreatic exocrine cells (2011) (6)
- [Molecular mechanism of insulin secretion]. (1997) (5)
- Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in a low birth weight mouse model (2014) (5)
- CACN4, the major alpha 1 subunit isoform of voltage-dependent calcium channels in pancreatic beta-cells: a minireview of current progress. (1995) (5)
- Effect of glucagon antiserum on somatostatin, glucagon and insulin release from the isolated perfused rat pancreas (1982) (5)
- Tracing phenotypic reversibility of pancreatic β‐cells in vitro (2010) (5)
- Yokoi, N. et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat. Genet. 31, 391-394 (2002) (4)
- KATP channels control the differential vulnerability of dopaminergic midbrain neurons in a chronic MPTP-model of Parkinson's disease (2005) (4)
- Alterations in N‐Methyl‐D‐Aspartate Receptor Subunit mRNA Expression Levels in Cerebral Cortex in Kindling‐Induced Epileptogenesis. (1996) (4)
- Immunohistochemical Localization of Calbindin-D28k in the Pancreas of Normal and KATP Channel-deficient Mice: Its Possible Role in the Prevention of Cell Damage to Islet Cells (2000) (4)
- Constitutive activation of Rac1 in pancreatic β cells facilitates F-actin depolymerization but exerts no influence on the increase of pancreatic β cell mass and facilitation of insulin secretion. (2013) (4)
- [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]. (2003) (4)
- Assignment1 of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23→q24 by in situ hybridization and radiation hybrid mapping (2000) (4)
- Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes. (2017) (4)
- Tumor‐like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin‐induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat (2020) (3)
- CELLULAR DISTRIBUTION OF SULFONYLUREA RECEPTOR 2 mRNA IN THE OVARY AND TESTIS OE RATS (1998) (3)
- Characteristics of repaglinide effects on insulin secretion (2018) (3)
- Identification and characterization of a novel member of the ATP-sensitive K channel subunit family , Kir 6 . 3 , in zebrafish (2006) (3)
- Genetics of the Spontaneously Diabetic Torii Rat (2011) (3)
- [Regeneration of the pancreas]. (2008) (3)
- Molecular Biology of the Islets of Langerhans: The organization and structure of insulin genes (1990) (3)
- Dentate Gyrus Granule Cells Channels in Mammalian ATP Analysis of Single K (2015) (3)
- Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells (2012) (3)
- Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer. (2022) (3)
- Insulin secretion and differential gene expression in glucose-responsive and-unresponsive MIN 6 sublines (2000) (2)
- Knockout of the K ATP channel subunit Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics (2003) (2)
- Involvement of ATP-sensitive potassium channels in central control of gasping (2005) (2)
- THE MECHANISM OF VAGAL CONTROL IN HYPOGLYCEMIA-INDUCED PANCREATIC POLYPEPTIDE SECRETION (1981) (2)
- Issue Information (2018) (2)
- The Islet and Metabolism Keep Time (2015) (2)
- A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent (2016) (2)
- Assignment of the human solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 gene (SLC4A10) to 2q23-->q24 by in situ hybridization and radiation hybrid mapping. (2000) (2)
- β‐Cell research – A decade of rapid growth (2009) (2)
- Perspectives in Diabetes Diverse Roles of K AT P Channels Learned From Kir 6 . 2 Genetically Engineered Mice (2000) (2)
- A case of type A insulin resistance associated with heterozygous Asn462Ser mutation of the insulin receptor gene (2012) (2)
- The mind and the belly: a glance at how the nervous system directs metabolism (2014) (2)
- Synaptotagmin genes on mouse Chromosomes 1, 7, and 10 and human Chromosome 19 (1995) (2)
- A monitor of secretion from single pancreatic beta-cells. (1995) (2)
- Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves (2021) (2)
- Maladaptive cardiac remodeling and mortality under mineralocorticoid induced hypertension following KATP channel knockout (2004) (2)
- Recent progress in the molecular genetic aspects of non-insulin-dependent diabetes mellitus. (1996) (2)
- The Sulfonylurea Receptor: The Regulator of ATP-Sensitive K + Channels@@@ATP感受性K + チャネルのレギュレーター (1997) (2)
- PKA-mediated phosphorylation and functional modulation of the ATP-sensitive K+ channels (2001) (1)
- Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy (2018) (1)
- [ATP sensitive potassium channels--Kir6.2 gene]. (1997) (1)
- P03-38 Suppressor of cytokine signaling 2 missense mutation identified in a patient with gigantism without growth hormone producing pituitary adenoma (2012) (1)
- PO147 INTERPLAY BETWEEN INCRETIN AND SULFONYLUREA THROUGH EPAC2A/RAP1 SIGNALING IN INSULIN SECRETION (2014) (1)
- Suramin inhibits glucose-induced Ca2+ response in single rat pancreatic beta cells. (1997) (1)
- [Regulatory mechanism of incretin secretion]. (2011) (1)
- LACTATE IS A MAJOR ENERGY SUBSTRATE FOR CORTICAL NEURONS AND ENHANCES THEIR FIRING ACTIVITY (2021) (1)
- The KATP Channel and the Sulfonylurea Receptor (2001) (1)
- Shifting the paradigm of islet inflammation—good guy or bad guy? (2013) (1)
- [Regulation of insulin secretion by incretins]. (2002) (1)
- Novel Member of the Otx Family 1 Otx 3 : identification , tissue expression and functional characterization of a novel member of the Otx family Running title : Otx 3 , a novel member of the Otx family (2002) (1)
- Harumi Glucose-induced Insulin Secretion Determines the Biphasic Response of Protein ( N-WASP ) and Cofilin Activities of Neuronal Wiskott-Aldrich Syndrome Actin Dynamics Regulated by the Balance Signal Transduction : (2013) (1)
- [The sulfonylurea receptor]. (1997) (1)
- Trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa (onions) has appreciable antidiabetic potential in streptozotocin-induced diabetic mice (2016) (1)
- Glucose transporters - molecular structure and function (1989) (1)
- β-cell glutamate signaling in insulin secretion: the physiological and pathophysiological roles (2016) (1)
- Subject Index Vol. 89, 2000 (2000) (0)
- PO141 PREFERENTIAL EXPRESSION OF LIVER SPECIFIC GENES AND EPIGENETIC MEMORY OF INDUCED PLURIPOTENT STEM CELLS DERIVED FROM MOUSE EXOCRINE PANCREAS (2014) (0)
- Role of Noc2 for Zymogen Granule Exocytosis Studied by Flash Photolysis of Caged Ca 2+ Compound and Multi-photon Excitation Microscopy (2004) (0)
- Issue Information (2015) (0)
- Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
- Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes (2015) (0)
- [Molecular mechanisms of insulin secretion]. (2003) (0)
- Contents Vol. 89, 2000 (2000) (0)
- Issue Information (2019) (0)
- An Exonic PointMutation oftheAndrogenReceptor Geneina Family withComplete AndrogenInsensitivity (1990) (0)
- DISTRIBUTION OF ATP-SENSITIVE K^+ CHANNELS IN PANCREAS (1998) (0)
- [Regenerative medicine of the pancreas]. (2003) (0)
- ATP-sensitive K + Hypoglycemia of of Genes Encoding the Pancreatic ~-cell Channel in Persistent Hyperinsulinemic Infancy in Japanese Patients (2006) (0)
- [Glucose can control cytosolic concentration of Ca2+and the secretion of insulin in beta cells without KATP canals by deficiency in subunit Kir6.2] (2008) (0)
- Kobe University Repository : Kernel タイトル Tit le Electrophysiological analyses of t ransgenic mice overexpressing KCNJ 8 with S 422 L mutat ion in cardiomyocytes 著者 (2018) (0)
- A Novel Mediator of Arsenic-Induced Pancreatic Beta-Cell Dysfunction (2018) (0)
- OP39 ROLE OF THE KATP CHANNEL IN GLUCOSE-INDUCED GIP SECRETION (2014) (0)
- Kobe University Repository : Kernel タイトル Tit le Establishment of new clonal pancreat ic β-cell lines ( MIN 6K ) useful for study of incret in / cyclic adenosine monophosphate signaling (2018) (0)
- Impaired incretin-induced insulin secretion in enlarged pancreatic islets in a novel animal model of obese type 2 diabetes (2016) (0)
- JCB_201304101 1..17 (2014) (0)
- A Critical Role of KATP Channels in the Maintenance of Glucose Homeostasis (2005) (0)
- diaphragm fatigue during normoxia and hypoxia channel blocker glibenclamide and (2015) (0)
- Oita International Electrocardiology Symposium 2000 “Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside” (2000) (0)
- Issue Information (2017) (0)
- sugar/polyol transport facilitators Nomenclature of the GLUT/SLC2A family of (2011) (0)
- Sarcolemmal ATP-sensitive K^+ channels and cardiovascular function (2000) (0)
- Genetic, comparative and physical mapping of the rat autoimmune type I diabetes locus Iddm/kdp1 (2000) (0)
- Importance of Dmbx1 in pleiotropic action of AgRP (2008) (0)
- OR5,25 Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes (2010) (0)
- Issue information (2019) (0)
- Molecular mechanism of cAMP-regulated insulin granule exocytosis (2005) (0)
- O-11 Diazoxide attenuates mitochondrial Ca2+ overload in Kir6.1- and Kir6.2-deficient mouse ventricular myocytes (2002) (0)
- Deficit combinato di GH, prolattina e TSH dell’adulto associato alla presenza di anticorpi anti-PIT-1 (2011) (0)
- zebrafish ATP-sensitive K+ channel subunit family, Kir6.3, in Identification and characterization of a novel member of (2013) (0)
- Donald F. Steiner: great scientist, close friend, real ‘Mensch’ (2015) (0)
- Channels + Mice Lacking Kir6.2-Containing ATP-Sensitive K Enhanced Neuronal Damage After Ischemic Insults in (2015) (0)
- Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy (2018) (0)
- Title Fructose induces glucose-dependent insulinotropic polypeptide , glucagon-like peptide-1 and insulin secretion : Role of adenosine triphosphate-sensitive K [ + ] channels (2018) (0)
- Stimulatory effect of imeglimin on incretin secretion. (2023) (0)
- Kobe University Repository : Kernel Tit le Rim 2 alpha determines docking and priming states ininsulin granule exocytosis (2016) (0)
- [Mechanism of regulation of insulin secretion in pancreatic beta-cells]. (2012) (0)
- Issue Information (2018) (0)
- BARP supresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis (2014) (0)
- Kobe University Repository : Kernel タイトル Tit le Sulfonylurea act ion re-revisited 著者 (2017) (0)
- Alain Ktorza, PhD (2017) (0)
- Protein Kinase A-Independent Mechanism of cAMP in Insulin Secretion (2008) (0)
- Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells (GTP-binding-protein-coupled receptor/gene famuly/phospholipase C/Ca signal) (2016) (0)
- Abstract 1507: Role of Sarcolemmal ATP-Sensitive K+ Channels in Sinoatrial Node Cells: Evaluation Using Kir6.2 Knockout Mice (2006) (0)
- [Role of a pituitary adenylate cyclase-activating polypeptide (PACAP) receptor in pancreatic beta-cell function]. (1994) (0)
- Issue Information (2016) (0)
- Studies on Cloned Cardiac and -Cell K AT P C h a n n e l s (1998) (0)
- Issue Information (2018) (0)
- Distinct roles of somatostatin in the control of glucagon secretion by glucose and KATP channel blockers from the perfused mouse pancreas (2015) (0)
- Metabolic state-dependent responses of GABAergic neurons in substantianigra pars reticulata (2005) (0)
- SUPPRESSIBILITY OF PLASMA MOTILIN BY ORALLY ADMINISTERED GLUCOSE IN PATIENTS WITH HYPERTHYROIDISM AND LIVER CIRRHOSIS (1980) (0)
- The effect of cAMP on cytosolic calcium oscillations in beta cells within mouse pancreatic slices (2013) (0)
- Issue Information (2016) (0)
- O-GlcNAcylation of myocyte-specific enhancer factor 2D negatively regulates insulin secretion from pancreatic β-cells. (2022) (0)
- Issue Information (2019) (0)
- Issue Information (2016) (0)
- [Roles of the cAMP sensor Epac2A in insulin secretion]. (2011) (0)
- THE MOLECULAR BASIS OF DRUG RESISTANCE IN FAMILIAL HYPERINSULINISM: FROM BEDSIDE TO PETRI DISH. (1997) (0)
- Inwardly rectifying potassium channels (KIR) in GtoPdb v.2021.3 (2021) (0)
- Response to Dupuis, Petersen, and Weydt (2012) (0)
- Endothelin converting enzyme expressed in human renal adenocarcinoma cells: its characteristics and molecular structure (1995) (0)
- OR08-2 IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells (2012) (0)
- Deletion of Kir6.2 worsens diastolic dysfunction in the stunned myocardium (2003) (0)
- PO387 IDENTIFICATION OF BIOMARKERS FOR PREDIABETES: A STUDY OF RAT MODELS OF TYPE 2 DIABETES (2014) (0)
- Diabetes, Obesity and Metabolism (2017) (0)
- More β-cell researchers are wanted! (2016) (0)
- Suramin inhibits the rise in cytoplasmic calcium concentration ([Ca2+]i) induced by glucose in single pancreatic b cells (1995) (0)
- ATP-SENSITIVE K+ CHANNEL IS NOT INVOLVED IN THE EXTRACELLULAR K+ ACCUMULATION IN ISCHEMIC MOUSE HEART (2005) (0)
- Glibenclamide blocks the cooperative nucleotide binding to sulfonylurea receptor SURl (1998) (0)
- Glucose potently inhibits glucagon secretion in mice with α-cell-specific deletion of KATP channels (2016) (0)
- [Contribution of Japanese researchers to the progress of studies in endocrinology and metabolism in the field of internal medicine in the last 100 years: ATP-sensitive potassium channel and insulin secretion]. (2002) (0)
- channel-deficient mice ATP skeletal muscle of K Treadmill running causes significant fiber damage in (2015) (0)
- Synaptotagmin III Isoform Is Compartmentalized in Pancreatic -Cells and Has a Functional Role in E x o c y t o s i s (2000) (0)
- Novel Epac2 isoforms and their roles in pancreatic β-cell functions (2020) (0)
- P02-17 Sirt1 negatively regulates IGF-I production by growth hormone via deacetylation of Stat5 in liver (2012) (0)
- Correction: A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent (2017) (0)
- Issue Information (2018) (0)
- Kobe University Repository : Kernel タイトル Tit le Essent ial roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incret in-induced insulin secret ion 著者 (2020) (0)
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What Schools Are Affiliated With Susumu Seino?
Susumu Seino is affiliated with the following schools:
