Svetlana Lutsenko
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Computer Science
Svetlana Lutsenko's Degrees
- Masters Artificial Intelligence Stanford University
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Svetlana Lutsenko's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Function and regulation of human copper-transporting ATPases. (2007) (657)
- Copper induces cell death by targeting lipoylated TCA cycle proteins (2022) (638)
- Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions. (1994) (349)
- Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotype-phenotype correlation, and functional analyses. (1997) (340)
- Human copper homeostasis: a network of interconnected pathways. (2010) (324)
- Wilson disease (2018) (265)
- N-terminal Domains of Human Copper-transporting Adenosine Triphosphatases (the Wilson’s and Menkes Disease Proteins) Bind Copper Selectively in Vivo and in Vitro with Stoichiometry of One Copper Per Metal-binding Repeat* (1997) (241)
- Human copper transporters: mechanism, role in human diseases and therapeutic potential. (2009) (227)
- Connecting copper and cancer: from transition metal signalling to metalloplasia (2021) (225)
- High Copper Selectively Alters Lipid Metabolism and Cell Cycle Machinery in the Mouse Model of Wilson Disease* (2007) (207)
- Function and Regulation of the Mammalian Copper-transporting ATPases: Insights from Biochemical and Cell Biological Approaches (2003) (199)
- Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. (1999) (183)
- Copper handling machinery of the brain. (2010) (183)
- Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice. (2006) (177)
- Cellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance. (2008) (177)
- The Copper-transporting ATPases, Menkes and Wilson Disease Proteins, Have Distinct Roles in Adult and Developing Cerebellum* (2005) (166)
- Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model (2012) (162)
- The Lys1010–Lys1325 Fragment of the Wilson's Disease Protein Binds Nucleotides and Interacts with the N-terminal Domain of This Protein in a Copper-dependent Manner* (2001) (155)
- Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs* (2009) (150)
- Metallochaperone Atox1 Transfers Copper to the NH2-terminal Domain of the Wilson's Disease Protein and Regulates Its Catalytic Activity* (2002) (149)
- Biochemical basis of regulation of human copper-transporting ATPases. (2007) (129)
- Localization of the Wilson's disease protein product to mitochondria. (1998) (124)
- Therapeutic Targeting of ATP7B in Ovarian Carcinoma (2009) (123)
- Defective cellular localization of mutant ATP7B in Wilson's disease patients and hepatoma cell lines. (2003) (122)
- Copper Regulates Cyclic AMP-Dependent Lipolysis (2016) (120)
- Diverse functional properties of Wilson disease ATP7B variants. (2012) (120)
- The N-terminal Metal-binding Site 2 of the Wilson's Disease Protein Plays a Key Role in the Transfer of Copper from Atox1* (2004) (112)
- Solution structure of the N-domain of Wilson disease protein: distinct nucleotide-binding environment and effects of disease mutations. (2006) (110)
- The Distinct Roles of the N-terminal Copper-binding Sites in Regulation of Catalytic Activity of the Wilson's Disease Protein* (2003) (105)
- Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease (2016) (101)
- Functional Properties of the Copper-transporting ATPase ATP7B (The Wilson's Disease Protein) Expressed in Insect Cells* (2002) (101)
- X-ray Absorption Spectroscopy of the Copper Chaperone HAH1 Reveals a Linear Two-coordinate Cu(I) Center Capable of Adduct Formation with Exogenous Thiols and Phosphines* (2003) (101)
- Copper Specifically Regulates Intracellular Phosphorylation of the Wilson's Disease Protein, a Human Copper-transporting ATPase* (2001) (101)
- Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins (2007) (101)
- Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism. (2007) (92)
- Golgi in copper homeostasis: a view from the membrane trafficking field (2013) (92)
- Wilson Disease at a Single Cell Level (2010) (83)
- The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution (2016) (81)
- Nanobodies as Probes for Protein Dynamics in Vitro and in Cells* (2015) (81)
- Structural organization of human Cu-transporting ATPases: learning from building blocks (2009) (78)
- Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level (2007) (77)
- Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway (2016) (76)
- Copper trafficking to the secretory pathway. (2016) (76)
- The Role of the Invariant His-1069 in Folding and Function of the Wilson's Disease Protein, the Human Copper-transporting ATPase ATP7B* (2003) (76)
- Functional Partnership of the Copper Export Machinery and Glutathione Balance in Human Cells* (2012) (74)
- Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B. (2009) (72)
- Atp7b-/- mice as a model for studies of Wilson's disease. (2008) (71)
- Human Copper-Transporting ATPase ATP7B (The Wilson's Disease Protein): Biochemical Properties and Regulation (2002) (67)
- Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice (2015) (65)
- Functional Interactions of Cu-ATPase ATP7B with Cisplatin and the Role of ATP7B in the Resistance of Cells to the Drug* (2009) (64)
- Urinary Copper Elevation in a Mouse Model of Wilson's Disease Is a Regulated Process to Specifically Decrease the Hepatic Copper Load (2012) (62)
- Systems biology approach to Wilson’s disease (2011) (62)
- The Distinct Functional Properties of the Nucleotide-binding Domain of ATP7B, the Human Copper-transporting ATPase* (2004) (61)
- An expanding range of functions for the copper chaperone/antioxidant protein Atox1. (2013) (59)
- Modifying factors and phenotypic diversity in Wilson's disease (2014) (57)
- The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin. (2009) (55)
- The Function of ATPase Copper Transporter ATP7B in Intestine. (2018) (55)
- Quantitative imaging of metals in tissues (2009) (53)
- Genome-Wide RNAi Ionomics Screen Reveals New Genes and Regulation of Human Trace Element Metabolism (2014) (53)
- A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism. (2012) (53)
- Cell‐Specific Trafficking Suggests a new role for Renal ATP7B in the Intracellular Copper Storage (2009) (53)
- The Role of Copper as a Modifier of Lipid Metabolism (2013) (53)
- Identification of a Novel Transcription Regulator from Proteus mirabilis, PMTR, Revealed a Possible Role of YJAI Protein in Balancing Zinc in Escherichia coli * (1998) (52)
- Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney. (2008) (51)
- Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. (2015) (51)
- COMMD1 Forms Oligomeric Complexes Targeted to the Endocytic Membranes via Specific Interactions with Phosphatidylinositol 4,5-Bisphosphate* (2009) (50)
- Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson’s Disease (2012) (49)
- Molecular Events Initiating Exit of a Copper-transporting ATPase ATP7B from the Trans-Golgi Network* (2012) (48)
- THE MENKES DISEASE PROTEIN BINDS COPPER VIA NOVEL 2-COORDINATE CU(I)-CYSTEINATES IN THE N-TERMINAL DOMAIN (1998) (48)
- Obesity is associated with copper elevation in serum and tissues. (2019) (47)
- Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein (2011) (46)
- Regulation of copper transporters in human cells. (2012) (45)
- ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase (2018) (44)
- The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria* (2016) (42)
- The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. (2009) (42)
- Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes (2018) (41)
- Identification of p38 MAPK and JNK as new targets for correction of Wilson disease‐causing ATP7B mutants (2016) (41)
- Copper transfer to the N-terminal domain of the Wilson disease protein (ATP7B): X-ray absorption spectroscopy of reconstituted and chaperone-loaded metal binding domains and their interaction with exogenous ligands. (2004) (41)
- The Lumenal Loop Met672–Pro707 of Copper-transporting ATPase ATP7A Binds Metals and Facilitates Copper Release from the Intramembrane Sites* (2011) (40)
- Interactions between Copper-binding Sites Determine the Redox Status and Conformation of the Regulatory N-terminal Domain of ATP7B* (2009) (40)
- The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics (2017) (40)
- Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B (2014) (40)
- Evolution of Copper Transporting ATPases in Eukaryotic Organisms (2012) (37)
- Animal models of Wilson disease (2018) (37)
- Functional Properties of the Human Copper‐Transporting ATPase ATP7B (the Wilson's Disease Protein) and Regulation by Metallochaperone Atox1 (2003) (37)
- Imaging Copper Metabolism Imbalance in Atp7b−/− Knockout Mouse Model of Wilson’s Disease with PET-CT and Orally Administered 64CuCl2 (2012) (36)
- Hepatocyte GP73 expression in Wilson disease. (2009) (35)
- Early gestational gene transfer with targeted ATP7B expression in the liver improves phenotype in a murine model of Wilson's disease (2011) (32)
- A systems approach implicates nuclear receptor targeting in the Atp7b(-/-) mouse model of Wilson's disease. (2012) (32)
- Interactions between Metal-binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding* (2014) (32)
- A Mutation in the ATP7B Copper Transporter Causes Reduced Dopamine β-Hydroxylase and Norepinephrine in Mouse Adrenal (2003) (32)
- Copper Transport and Disease: What Can We Learn from Organoids? (2019) (32)
- Difference in Stability of the N-domain Underlies Distinct Intracellular Properties of the E1064A and H1069Q Mutants of Copper-transporting ATPase ATP7B* (2011) (31)
- Copper and the brain noradrenergic system (2019) (31)
- Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells (2017) (30)
- Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase. (2012) (30)
- Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. (2017) (29)
- Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease. (2011) (28)
- Myosin Vb mediates Cu+ export in polarized hepatocytes (2016) (20)
- Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations. (2004) (20)
- Dynamic and cell-specific transport networks for intracellular copper ions. (2021) (17)
- The Wilson's disease protein expressed in Sf9 cells is phosphorylated. (2001) (17)
- Changes in mammalian copper homeostasis during microbial infection. (2020) (16)
- Estimating Thyroid Masses for Children, Infants, and Fetuses in Ukraine Exposed to 131I From the Chernobyl Accident (2013) (16)
- ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly (2019) (14)
- Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties (2020) (14)
- Expression of ZntA, a Zinc‐Transporting P1‐Type ATPase, is Specifically Regulated by Zinc and Cadmium (2000) (13)
- Delivery of the Cu-transporting ATPase ATP7B to the plasma membrane in Xenopus oocytes. (2008) (13)
- Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein. (2019) (11)
- Introduction to Human Disorders of Copper Metabolism (2014) (11)
- pH-regulated metal-ligand switching in the HM loop of ATP7A: a new paradigm for metal transfer chemistry. (2016) (10)
- Localization of the Locus Coeruleus in the Mouse Brain. (2019) (10)
- Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease (2021) (9)
- Atp 7 b − / − mice as a model for studies of Wilson ’ s disease (2008) (8)
- Copper‐Transporting ATPases: Key Regulators of Intracellular Copper Concentration (2005) (7)
- Using XAS and SXRF to Study Copper in Wilson Disease at the Molecular and Tissue Level (2007) (6)
- The Stabilization of Cation Binding and its Relation to Na+/K+-ATPase Structure and Function (1994) (5)
- Molecular Architecture of the Copper-Transporting ATPase ATP7B (2019) (5)
- NMR assignment of the Wilson disease associated protein N-domain (2006) (5)
- The Wilson ' s disease protein expressed in Sf 9 cells is phosphorylated (2009) (4)
- Wilson Disease: Update on Pathophysiology and Treatment (2022) (4)
- Copper in eukaryotes (2014) (4)
- Sending copper where it is needed most (2020) (4)
- Copper Metabolism, ATP7A and Menkes Disease (2015) (3)
- Insulin signaling and copper homeostasis are functionally linked in 3T3‐L1 adipocytes (992.2) (2014) (3)
- HEPATIC STEATOSIS IN THE MOUSE MODEL OF WILSON DISEASE COINCIDES WITH A MUTED INFLAMMATORY RESPONSE. (2021) (3)
- CHAPTER 18:Copper in Eukaryotes (2014) (3)
- Purification and characterization of a small copper carrier found in mammalian blood plasma and in the urine of mice and dogs with copper overload (2016) (2)
- Introduction to the Minireview Series on Modern Technologies for In-cell Biochemistry* (2015) (2)
- Myosin Vb mediates copper export in polarized hepatocytes (2016) (2)
- Oxysterol misbalance critically contributes to Wilson disease pathogenesis (2022) (1)
- Relation of Copper Toxicosis in Dogs and Wilson Disease to the Appearance of a Small Copper Carrier (SCC) in Blood Plasma and Urine (2015) (1)
- Biochemical and Cellular Properties of ATP7B Variants (2019) (1)
- Solution structure of the Wilson ATPase N-domain in the presence of ATP (2006) (1)
- DAMAGE TO SPRING WHEAT DUE TO HARMFUL ORGANISMS IN CONNECTION WITH SOWING TIME AND GROWTH REGULATORS APPLICATION IN THE CONDITIONS OF PRE-BAIKAL REGION (2013) (1)
- Mechanism of human copper transporter wilson's disease protein (2016) (1)
- Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner (2022) (1)
- Wilson ’ s Disease Protein (2019) (1)
- Metal Metabolism: Transport, Development and Neurodegeneration (2008) (1)
- A Century of Progress on Wilson Disease and the Enduring Challenges of Genetics, Diagnosis, and Treatment (2023) (1)
- Genetic, metabolic and cellular factors influencing intracellular localization of the Wilson disease protein, ATP7B (2014) (1)
- P-Type Pumps: Copper Pump (2013) (1)
- The liver copper status alters the development of steatosis in mice (2020) (0)
- Connecting copper and cancer: from transition metal signalling to metalloplasia (2021) (0)
- Trafficking of copper transporter ATP7B: implication in cancer and rare diseases (2013) (0)
- Correction: Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein. (2019) (0)
- expression in an infant rat model absorption, tissue distribution, and copper transporter Effects of copper supplementation on copper (2011) (0)
- Golgi in copper homeostasis: a view from the membrane trafficking field (2013) (0)
- Cancer Therapy: Preclinical Therapeutic Targeting of ATP7B in Ovarian Carcinoma (2009) (0)
- Molecular architecture of human ATP 7 B 1 HUMAN COPPER TRANSPORTER ATP 7 B ( WILSON DISEASE PROTEIN ) FORMS STABLE DIMERS IN VITRO AND IN CELLS (2017) (0)
- The role of intestine in metabolic dysregulation in murine Wilson disease (2023) (0)
- Editor's Note: Therapeutic Targeting of ATP7B in Ovarian Carcinoma (2021) (0)
- Steatosis development in the mouse model of Wilson disease coincides with a muted inflammatory response (2021) (0)
- Live-cell imaging of compartment-specific redox changes in menkes disease fibroblasts (2014) (0)
- Membrane Transport | Copper Pumps (2021) (0)
- Biochemistry of the Wilson’s Disease Protein (2002) (0)
- Nanobodies against the metal binding domains of ATP7B as tools to study copper transport in the cell. (2020) (0)
- Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain (2023) (0)
- MOLECULAR MODELING OF THE NUCLEOTIDE-BINDING DOMAIN OF THE WILSON' DISEASE PROTEIN: THE ATP-BINDING SITE AND DOMAIN DYNAMICS (2004) (0)
- Live-cell imaging of compartment-specific redox changes in menkes disease fibroblasts (2014) (0)
- Genetic, metabolic and cellular factors influencing intracellular localization of the Wilson disease protein, ATP7B (2014) (0)
- X-ray absorption studies of copper chaperones (2003) (0)
- THE LIVER COPPER STATUS ALTERS THE DEVELOPMENT OF STEATOSIS IN MICE (2021) (0)
- Identification andAnalysis ofMutations intheWilson Disease Gene (ATP7H): Population Frequencies, Genotype-Phenotype Correlation, (1997) (0)
- Copper Transporting ATPases in Mammalian Cells (2013) (0)
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