Sylvain Lesné

Q: What Schools Are Affiliated With Sylvain Lesné

Sylvain Lesné is affiliated with the following schools: Université Paris Cité, University of Minnesota, Stanford University, University of California, San Francisco

Sylvain Lesné's AcademicInfluence.com Rankings

Sylvain Lesné

Biology

#3948

World Rank

#5964

Historical Rank

Neuroscience

#2362

World Rank

#2426

Historical Rank

Biochemistry

#2690

World Rank

#2873

Historical Rank

biology Degrees

Download Badge

Biology

Sylvain Lesné's Degrees

PhD Neuroscience Université Paris Cité
Masters Biology Université Paris Cité
Bachelors Biochemistry Université Paris Cité

Similar Degrees You Can Earn

Best Online Master's in Biology

Why Is Sylvain Lesné Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Sylvain E. Lesné is a French neuroscientist and associate professor at the Department of Neuroscience at the University of Minnesota Medical School, known for his research into Alzheimer's disease. He is the primary author of a 2006 Nature paper that is foundational in the hypothesis that one specific toxic oligomer of the amyloid beta protein, known as Aβ*56, is a cause of memory impairment in Alzheimer's, aligned with the prevailing amyloid hypothesis.

(See a Problem?)

Sylvain Lesné's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A specific amyloid-β protein assembly in the brain impairs memory (2006) (2572)
A specific amyloid-beta protein assembly in the brain impairs memory. (2006) (1267)
Brain amyloid-β oligomers in ageing and Alzheimer's disease. (2013) (367)
Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models* (2007) (352)
Soluble Aβ oligomer production and toxicity (2012) (325)
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis. (2021) (236)
The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease (2012) (234)
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. (2008) (216)
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid‐β oligomers (2006) (186)
Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain (2000) (184)
NMDA Receptor Activation Inhibits α-Secretase and Promotes Neuronal Amyloid-β Production (2005) (180)
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. (2007) (174)
Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function (2008) (166)
Cognitive effects of cell-derived and synthetically derived Aβ oligomers (2011) (150)
Soluble α-Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology (2012) (117)
Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity (2007) (115)
Transforming Growth Factor-β1 Potentiates Amyloid-β Generation in Astrocytes and in Transgenic Mice* (2003) (110)
β-Amyloid Modulation of Synaptic Transmission and Plasticity (2007) (101)
NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. (2005) (94)
Angiopoietin‐1‐induced phosphatidyl‐inositol 3‐kinase activation prevents neuronal apoptosis (2003) (83)
The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation (2017) (80)
Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures (2008) (79)
Smad3-Dependent Induction of Plasminogen Activator Inhibitor-1 in Astrocytes Mediates Neuroprotective Activity of Transforming Growth Factor-β1 against NMDA-Induced Necrosis (2002) (78)
Beta-amyloid modulation of synaptic transmission and plasticity. (2007) (74)
Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease (2014) (72)
Transforming Growth Factor-β and Ischemic Brain Injury (2003) (71)
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease (2016) (70)
Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription (2004) (63)
Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. (2003) (57)
Transforming growth factor-beta and ischemic brain injury. (2003) (56)
Akt-dependent Expression of NAIP-1 Protects Neurons against Amyloid-β Toxicity* (2005) (53)
Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities (2005) (52)
Transforming growth factor α‐induced expression of type‐1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity (2003) (49)
Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy (2019) (45)
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits (2017) (42)
Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription. (2004) (41)
Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport (2016) (39)
Increased Expression of Transforming Growth Factor-β after Cerebral Ischemia in the Baboon: An Endogenous Marker of Neuronal Stress? (2001) (36)
Detecting aβ*56 oligomers in brain tissues. (2011) (35)
Brain amyloid- b oligomers in ageing and Alzheimer’s disease (2013) (31)
Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing issue. (2014) (28)
Breaking the Code of Amyloid-β Oligomers (2013) (27)
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity. (2005) (26)
Transforming Growth Factor-β1—Modulated Cerebral Gene Expression (2002) (26)
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk (2020) (25)
Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons (2018) (24)
Amyloid Plaques and Amyloid-β Oligomers: An Ongoing Debate (2005) (21)
Amyloid plaques and amyloid-beta oligomers: an ongoing debate. (2005) (13)
Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. (2017) (10)
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD (2013) (6)
[Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?]. (2003) (4)
Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002. (2003) (3)
Cellular prion protein and class-specific Aβ oligomers mediate plaque-associated cytopathology in a mouse model of Alzheimer’s disease (2015) (1)
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD (2013) (1)
Abeta dimers mediate plaque-associated cytopathology without affecting cognition (2011) (1)
Sex-specific interactions between procedural and deliberative decision-making systems in a mouse model of Alzheimer’s disease (2021) (0)
Differential contribution of soluble forms of α-synuclein, TDP-43 and PrPc to Alzheimer's disease-associated cognitive impairment (2011) (0)
Breaking the code of amyloid-? oligomers (2013) (0)
Comment on “Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice” (2022) (0)
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex (2022) (0)
Human Aβ dimers bind to PrPc to activate Fyn in Alzheimer's disease (2012) (0)
Specific alterations of tau phosphorylation and neuronal signaling induced by the amyloid-β oligomer Aβ*56 (2016) (0)
Longevity factor klotho and resistance to cognitive deficits in a transgenic mouse model and in individuals with Parkinson’s disease (2020) (0)
Evolution of Brain Aβ Oligomers Interactomes during the Course of Alzheimer's Disease (2010) (0)

This paper list is powered by the following services:

Other Resources About Sylvain Lesné

What Schools Are Affiliated With Sylvain Lesné?

Sylvain Lesné is affiliated with the following schools:

Sylvain Lesné's Academic­Influence.com Rankings

Sylvain Lesné's Degrees

Similar Degrees You Can Earn

Why Is Sylvain Lesné Influential?

Sylvain Lesné's Published Works

Published Works

Other Resources About Sylvain Lesné

What Schools Are Affiliated With Sylvain Lesné?

Sylvain Lesné's AcademicInfluence.com Rankings