Thomas E. Eling

Q: What Schools Are Affiliated With Thomas E. Eling

Thomas E. Eling is affiliated with the following schools: Tottori University, University of Tennessee, University of Iowa

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Thomas E. Eling

Biology

#8889

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#12027

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Cell Biology

#362

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#372

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Molecular Biology

#1161

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#1187

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Biochemistry

#1313

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#1433

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Biology

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Thomas E. Eling's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin (2007) (811)
The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates. (1982) (739)
Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. (2001) (421)
Prostaglandin H synthase and xenobiotic oxidation. (1990) (292)
Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells. (1994) (232)
Role of reactive oxygen species in LPS‐induced production of prostaglandin E2 in microglia (2004) (220)
Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. (2002) (197)
Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells (1999) (189)
A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. (1977) (188)
Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ (2003) (179)
Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. (2004) (169)
Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. (2006) (168)
NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism (2014) (160)
Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein (2005) (159)
Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation* (1997) (155)
Opposing Effects of 15-Lipoxygenase-1 and -2 Metabolites on MAPK Signaling in Prostate (2002) (147)
Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene EGR-1* (2004) (144)
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. (2001) (137)
Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene. (2002) (135)
Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. (2002) (129)
The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. (2013) (126)
NSAID activated gene (NAG-1), a modulator of tumorigenesis. (2006) (126)
Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. (1992) (125)
Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. (2006) (125)
Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. (2005) (125)
Nitric Oxide Trapping of Tyrosyl Radicals Generated during Prostaglandin Endoperoxide Synthase Turnover (1998) (123)
Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter (2001) (118)
Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins. (1990) (117)
Expression of 15-lipoxygenase-1 in human colorectal cancer. (1999) (117)
Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor. (1988) (115)
Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. (2002) (112)
A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies. (1980) (111)
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. (2000) (109)
15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway* (2001) (109)
Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase. (1992) (108)
Functional characterization of cyclooxygenase-2 polymorphisms. (2001) (104)
Identification of Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway* (2004) (104)
The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3) (2005) (103)
Accumulation of amines in the isolated perfused rabbit lung. (1974) (102)
Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs. (1973) (100)
Analysis of leukotrienes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. (1984) (98)
Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion. (1986) (97)
Co-oxidation of benzidine by prostaglandin synthase and comparison with the action of horseradish peroxidase. (1983) (96)
Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. (1993) (94)
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. (2003) (92)
Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. (2019) (91)
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. (1999) (90)
Xenobiotic metabolism by prostaglandin H synthase. (1992) (89)
Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53‐dependent mechanism and inhibition of prostate cancer cell growth (2006) (88)
hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling (2014) (88)
Prostaglandin synthetase-dependent cooxidation of (+/-)-benzo(a)pyrene-7,8-dihydrodiol by human lung and other mammalian tissues. (1981) (88)
The formation of sulfur trioxide radical anion during the prostaglandin hydroperoxidase-catalyzed oxidation of bisulfite (hydrated sulfur dioxide). (1982) (86)
Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase. (1983) (86)
Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation. (2015) (84)
Changes in gene expression contribute to cancer prevention by COX inhibitors. (2006) (84)
Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets. (2014) (83)
Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. (1984) (82)
Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. (2005) (82)
Protein Kinase C-dependent Regulation of NAG-1/Placental Bone Morphogenic Protein/MIC-1 Expression in LNCaP Prostate Carcinoma Cells* (2005) (81)
Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity* (1996) (81)
15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. (2004) (81)
Xenobiotic metabolism by prostaglandin endoperoxide synthetase. (1983) (80)
Metabolism of benzo(a)pyrene to reactive intermediate(s) via prostaglandin biosynthesis. (1978) (80)
Bioactivation of xenobiotics by prostaglandin H synthase. (1991) (79)
Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. (2004) (79)
Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase. (1983) (79)
Prostaglandin removal and metabolism by isolated perfused rat lung. (1976) (77)
The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases. (1983) (77)
The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15 (2005) (76)
Transcriptional Regulation of Cyclooxygenase-1 by Histone Deacetylase Inhibitors in Normal Human Astrocyte Cells* (2002) (74)
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. (2006) (73)
A novel peroxisome proliferator–activated receptor γ ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells (2006) (73)
Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (73)
Oxidative metabolism of diethylstilbestrol by prostaglandin synthetase. (1982) (71)
Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. (1996) (71)
Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. (1999) (71)
Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis. (1991) (69)
The effect of 15-Lipoxygenase-1 expression on cancer cells (2002) (68)
Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells (2003) (67)
Superoxide and peroxyl radical generation from the reduction of polyunsaturated fatty acid hydroperoxides by soybean lipoxygenase. (1991) (67)
Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism. (1986) (67)
Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. (1999) (66)
Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. (2000) (66)
Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures. (1983) (65)
A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. (2008) (65)
The Linoleic Acid Metabolite, (13S)-Hydroperoxyoctadecadienoic Acid, Augments the Epidermal Growth Factor Receptor Signaling Pathway by Attenuation of Receptor Dephosphorylation (1997) (64)
Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes. (1981) (64)
A study of the dynamics of imipramine accumulation in the isolated perfused rabbit lung. (1975) (64)
The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived. (1982) (63)
Production of arachidonic acid metabolites by macrophages exposed in vitro to asbestos, carbonyl iron particles, or calcium ionophore. (1985) (63)
Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. (1986) (62)
Cooxidation of the clinical reagent 3,5,3'5'-tetramethylbenzidine by prostaglandin synthase. (1982) (62)
Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. (2003) (62)
The formation of aminopyrine cation radical by the peroxidase activity of prostaglandin H synthase and subsequent reactions of the radical. (1985) (62)
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. (1997) (61)
The oxidation of arachidonic acid by the cyclooxygenase activity of purified prostaglandin H synthase: spin trapping of a carbon-centered free radical intermediate. (1986) (60)
Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. (1990) (60)
Mechanism of inhibition of prostaglandin H synthase by eugenol and other phenolic peroxidase substrates. (1989) (59)
Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice (2009) (59)
A role for phospholipids in the binding and metabolism of drugs by hepatic microsomes. Use of the fluorescent hydrophobic probe 1-anilinonaphthalene-8-sulphonate. (1971) (59)
Separation of arachidonic acid metabolites by high-pressure liquid chromatography. (1982) (58)
Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. (2001) (58)
Formation of free radical metabolites in the reaction between soybean lipoxygenase and its inhibitors. An ESR study. (1989) (58)
Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. (2002) (56)
Resveratrol-Induced Apoptosis Is Mediated by Early Growth Response-1, Krüppel-Like Factor 4, and Activating Transcription Factor 3 (2011) (56)
Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase. (1992) (56)
Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. (2003) (55)
Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1) (2007) (55)
Metabolism of arachidonic acid by human nasal and bronchial epithelial cells. (1988) (54)
Evidence for a one-electron mechanism of 2-aminofluorene oxidation by prostaglandin H synthase and horseradish peroxidase. (1984) (52)
Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models. (2016) (52)
Drug-Induced Expression of Nonsteroidal Anti-Inflammatory Drug-Activated Gene/Macrophage Inhibitory Cytokine-1/Prostate-Derived Factor, a Putative Tumor Suppressor, Inhibits Tumor Growth (2006) (52)
Biosynthesis of prostaglandins by isolated and cultured airway epithelial cells. (1986) (51)
Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression. (2014) (51)
Pulmonary intravascular macrophages metabolize arachidonic acid in vitro. Comparison with alveolar macrophages. (1988) (50)
Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen. (1986) (50)
Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways (2005) (50)
NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response (2013) (50)
Arachidonic acid metabolism by isolated epidermal basal and differentiated keratinocytes from the hairless mouse. (1986) (49)
A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L (2005) (49)
Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. (1998) (48)
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1 (2005) (48)
Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase. (1982) (47)
The cytochrome P-450 monooxygenase system of rabbit bladder mucosa: enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene. (1985) (46)
Prostaglandin synthetase and cytochrome P-450-dependent metabolism of (+/-)benzo(a)pyrene 7,8-dihydrodiol by enriched populations of rat Clara cells and alveolar type II cells. (1983) (46)
Phenylbutazone-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. A new mechanism for prostaglandin H synthase-catalyzed oxidations. (1984) (46)
Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C. (1996) (45)
Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene via a hydroperoxide-dependent mechanism catalyzed by lipoxygenases. (1989) (45)
The influence of environmental agents on prostaglandin biosynthesis and metabolism in the lung. Inhibition of lung 15-hydroxyprostaglandin dehydrogenase by exposure of guinea pigs to 100 per cent oxygen at atmospheric pressure. (1975) (45)
An electron spin resonance study of the activation of benzidine by peroxidases. (1983) (45)
Studies of the mechanisms involved in the fate of prostacyclin (PGI2) and 6-keto-PGF1alpha in the pulmonary circulation. (1978) (45)
A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation. (1981) (44)
Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene (2005) (44)
Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthase and horseradish peroxidase. (1986) (44)
Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter BASAL TRANSCRIPTION IS MEDIATED BY Sp1 AND Sp3* (2001) (43)
Detection of glutathione thiyl free radical catalyzed by prostaglandin H synthase present in keratinocytes. Study of co-oxidation in a cellular system. (1989) (43)
Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism. (1970) (42)
Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations. (1974) (42)
A GATA binding site is involved in the regulation of 15‐lipoxygenase‐1 expression in human colorectal carcinoma cell line, Caco‐2 (2000) (42)
ADPase activity of isolated perfused rat lung. (1978) (42)
Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid. (1974) (41)
Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1/GDF15) Expression Is Increased by the Histone Deacetylase Inhibitor Trichostatin A* (2008) (41)
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. (2001) (41)
The effect of ozone exposure on rat alveolar macrophage arachidonic acid metabolism. (1991) (39)
DNA methylation‐mediated silencing of nonsteroidal anti‐inflammatory drug‐activated gene (NAG‐1/GDF15) in glioma cell lines (2012) (38)
Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. (2003) (36)
COX inhibitors directly alter gene expression: role in cancer prevention? (2011) (35)
The oxidation of N-substituted aromatic amines by horseradish peroxidase. (1989) (35)
The pharmacodynamics of 5-hydroxytryptamine uptake and metabolism by the isolated perfused rabbit lung. (1975) (35)
Studies on the persistence of basic amines in the rabbit lung. (1979) (35)
Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells. (1982) (34)
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. (2009) (34)
Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. (1999) (34)
Metabolism of aromatic amines by prostaglandin H synthase. (1985) (34)
Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis. (1982) (34)
Lower NLRP3 Inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity (2013) (34)
Respiratory movements alter the generation of prostacyclin and thromboxane A2 in isolated rat lungs: the influence of arachidonic acid-pathway inhibitors on the ratio between pulmonary prostacyclin and thromboxane A2. (1981) (34)
Uptake, metabolism and efflux of methadone in "single pass" isolated perfused rabbit lungs. (1976) (33)
Formation of unique arylamine:DNA adducts from 2-aminofluorene activated by prostaglandin H synthase. (1985) (33)
Cellular proliferation and lipid metabolism: importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis (1994) (33)
Arachidonic acid-dependent cooxidation. A potential pathway for the activation of chemical carcinogens in vivo. (1984) (33)
Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung. (2018) (32)
Peroxidase-catalyzed oxidation of (bi)sulfite: reaction of free radical metabolites of (bi)sulfite with (+/-)-7,8-dihydroxy-7, 8-dihydroxy[a]pyrene. (1988) (32)
Prostaglandin H synthase-dependent co-oxygenation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants. (1984) (32)
Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. (1994) (32)
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents. (2008) (31)
Overexpression of 15-Lipoxygenase-1 Induces Growth Arrest through Phosphorylation of p53 in Human Colorectal Cancer Cells (2005) (31)
Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum. (1988) (31)
Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. (1978) (31)
Prostaglandin H synthase-dependent mutagenic activation of benzidine in a Salmonella typhimurium Ames tester strain possessing elevated N-acetyltransferase levels. (1989) (31)
Relative activities of retrovirally expressed murine prostaglandin synthase-1 and -2 depend on source of arachidonic acid. (1996) (30)
Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice (2010) (30)
Comparison of arachidonic acid metabolism by pulmonary intravascular and alveolar macrophages exposed to particulate and soluble stimuli. (1989) (29)
Regulation of murine hematopoiesis by arachidonic acid metabolites. (1989) (29)
Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines. (1989) (29)
Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins. (1977) (29)
Inhibition of pulmonary prostaglandin metabolism by exposure of animals to oxygen or nitrogen dioxide. (1979) (28)
Ionizing Radiation Enhances the Expression of the Nonsteroidal Anti-inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells (2006) (28)
The Role of NAG-1/GDF15 in the Inhibition of Intestinal Polyps in APC/Min Mice by Sulindac (2011) (28)
Analysis and quantitation of splicing variants of the TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells. (1995) (28)
Covalent binding of an intermediate(s) in prostaglandin biosynthesis to guinea pig lung microsomal protein. (1977) (27)
Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. (1996) (27)
Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4'-(acetylamino)biphenyl. (1992) (27)
The formation of styrene glutathione adducts catalyzed by prostaglandin H synthase. A possible new mechanism for the formation of glutathione conjugates. (1986) (27)
Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells (2003) (27)
Characterization of prostaglandins by combined gas-liquid chromatography and chemical ionization mass spectrometry. (1974) (26)
Carbon-centered free radical intermediates in the hematin- and ram seminal vesicle-catalyzed decomposition of fatty acid hydroperoxides. (1986) (26)
Metabolism of prostaglandin endoperoxide by microsomes from human lung parenchyma and comparison with metabolites produced by pig, bovine, rat, mouse and guinea-pig. (1982) (26)
Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice. (1983) (26)
Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway. (2003) (26)
Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism (2008) (25)
Embryonic Expression of Cyclooxygenase-2 Causes Malformations in Axial Skeleton* (2010) (25)
Enhanced mutagenicity of anisidine isomers in bacterial strains containing elevated N-acetyltransferase activity. (1992) (25)
Pulmonary biosynthesis and metabolism of prostaglandins and related substances. (1984) (25)
Separation of prostaglandins, thromboxane, hydroxy fatty acids and arachidonic acid by high pressure liquid chromatography. (1980) (25)
Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester: mediation by protein kinase C. (1991) (24)
Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: relationship to inhibition of prostaglandin cyclooxygenase. (1988) (24)
Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. (1999) (23)
15-lipoxygenase-1 overexpression in prostate adenocarcinoma. (2002) (23)
Pulmonary intravascular macrophages produce prostaglandins and leukotrienes in vitro. (1988) (23)
The interaction of a fluorescent probe with rat hepatic microsomes. (1970) (23)
Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase. (1991) (23)
Chemical structure of the adducts formed by the oxidation of benzidine in the presence of phenols. (1982) (23)
The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis. (1999) (23)
EGR1 is a novel target for AhR agonists in human lung epithelial cells. (2004) (23)
Prostaglandin H synthase-catalyzed metabolism and DNA binding of 2-naphthylamine. (1987) (22)
The formation of 2-aminofluorene-DNA adducts in vivo: evidence for peroxidase-mediated activation. (1989) (21)
Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor-dependent DNA synthesis and c-myc proto-oncogene expression in Syrian hamster embryo cells. (1993) (21)
Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. (2010) (21)
The H6D variant of NAG‐1/GDF15 inhibits prostate xenograft growth in vivo (2012) (20)
Arachidonic acid metabolism in respiratory epithelial cells. (1988) (20)
Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. (1995) (20)
Ozone inhibits endothelial cell cyclooxygenase activity through formation of hydrogen peroxide. (1987) (20)
Studies on the covalent binding of an intermediate(s) in prostaglandin biosynthesis to tissue macromolecules. (1979) (20)
The oxidation of 4-aminobiphenyl by horseradish peroxidase. (1992) (20)
Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. (1985) (20)
Ram seminal vesicle microsome-catalyzed activation of benzidine and related compounds: dissociation of mutagenesis from peroxidase-catalyzed formation of DNA-reactive material. (1988) (19)
Arachidonic Acid-Dependent Metabolism of Chemical Carcinogens and Toxicants (1985) (19)
Cooxidation of steroidal and non-steroidal estrogens by purified prostaglandin synthase results in a stimulation of prostaglandin formation. (1987) (19)
Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ. (1993) (19)
Peroxidative oxidation of bilirubin during prostaglandin biosynthesis. (1985) (19)
Retinoid-induced differentiation regulates prostaglandin H synthase and cPLA2 expression in tracheal epithelium. (1996) (18)
The Cyclooxygenase Inhibitor Sulindac Sulfide Inhibits EP4 Expression and Suppresses the Growth of Glioblastoma Cells (2009) (18)
A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. (1983) (18)
Uptake and metabolism of prostaglandins by isolated perfused lung: species comparisons and the role of plasma protein binding. (1977) (18)
Conjugation of 15-keto-prostaglandins by glutathione S-transferases. (1978) (18)
Modulation of c-jun and jun-B messenger RNA and inhibition of DNA synthesis by prostaglandin E2 in Syrian hamster embryo cells. (1992) (18)
Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism. (1985) (18)
Expression of Gab1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression (2001) (17)
Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin β-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells (2004) (17)
15‐Lipoxygenase‐1 activates tumor suppressor p53 independent of enzymatic activity (2008) (17)
Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells. (2013) (17)
ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. (1993) (17)
The prostaglandin H synthase-dependent activation of 2-aminofluorene to products mutagenic to S. typhimurium strains TA98 and TA98NR. (1985) (16)
The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. (2005) (16)
The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products. (1987) (16)
Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase. (1990) (15)
Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. (2002) (15)
Macromolecular binding of the thyroid carcinogen 3-amino-1,2,4-triazole (amitrole) catalyzed by prostaglandin H synthase, lactoperoxidase and thyroid peroxidase. (1987) (15)
Inhibition of EGF-dependent mitogenesis by prostaglandin E2 in Syrian hamster embryo fibroblasts. (1998) (15)
Synthesis of tropine-labeled atropine. I. Micro methods for the synthesis of tropine and for its esterification with tropic acid. (1967) (15)
Peroxidase-mediated formation of glutathione conjugates from polycyclic aromatic dihydrodiols and insecticides. (1989) (14)
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways. (1995) (14)
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice (2021) (13)
The oxidation of the calcium probe quin2 and its analogs by prostaglandin H synthase. (1989) (13)
Covalent binding of prostaglandins G2 and H2 to components of ram seminal vesicle microsomal fraction. (1979) (13)
Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung (1976) (13)
Covalent binding of intermediates formed during the metabolism of arachidonic acid by human platelet subcellular fractions. (1979) (13)
Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase. (1996) (13)
Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells. (1998) (13)
Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts. (1996) (12)
Prostaglandin H synthase-mediated bioactivation of the amino acid pyrolysate product Trp P-2. (1986) (12)
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association. (1999) (12)
Arachidonic acid metabolism in normal and transformed rat tracheal epithelial cells and its possible role in the regulation of cell proliferation. (1989) (11)
Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level (1999) (11)
Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1. (1986) (11)
Kinetic changes in microsomal drug metabolism with age and diphenylhydantoin treatment. (1970) (11)
Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. (2001) (10)
Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. (2008) (10)
Binding of iron beads to sialic acid residues on macrophage membranes stimulates arachidonic acid metabolism. (1985) (9)
Mechanism of 12-O-tetradecanoylphorbol-13-acetate enhanced metabolism of arachidonic acid in dog urothelial cells. (1990) (9)
Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages (1995) (9)
Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. (1997) (8)
Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation (2022) (8)
Metabolism of prostaglandin PG-F2 alpha by freshly isolated alveolar type II cells from lungs of adult male or pregnant rabbits. (1987) (8)
Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. (1980) (7)
Prostaglandin release and the interaction of platelets with the pulmonary vasculature of rat and guinea pig. (1980) (7)
Synthesis of tropine-labeled atropine II. Prototype synthesis for the preparation of tropine-14C and atropine-14C from arabinose-14C. (1967) (7)
Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation (2016) (6)
Synthesis of rropine-labeled atropine 3. Synthesis of N-methyl-14C-tropine and N-methyl-14C-atropine. (1968) (6)
Studies on the biosynthesis, metabolism and transport of prostaglandins by the lung (1976) (6)
Peroxidase-mediated glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol is enhanced by benzo[a]pyrene phenols in vitro. (1992) (6)
Prostacyclin and thromboxane A2 release in isolated rat lungs. (1982) (6)
Activation of TRPA1 by volatile organic chemicals leading to sensory irritation. (2019) (6)
NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets (2022) (5)
Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. (2001) (5)
BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity (2008) (5)
High-pressure liquid chromatography of neurotoxic phenylphosphonothioate esters and related compounds. (1980) (5)
Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. (2008) (3)
Prostaglandin H synthase-catalyzed ring oxygenation of 2-naphthylamine: evidence for two distinct oxidation pathways. (1995) (3)
(t10c12-CLA) in a polygenic obese line of mice -12-conjugated linoleic acid cis -10, trans elicited by Functional genomic characterization of delipidation (2005) (3)
Epidermal Growth Factor Regulation of Linoleic Acid Metabolism in Syrian Hamster Embryo Fibroblasts (1993) (3)
Functional genomic characterization of polygenic obese mice fed t10, c12 conjugated linoleic acid (2004) (2)
Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. (1991) (2)
13(S)-HpODE augments epidermal growth factor signal transduction by attenuating EGF receptor dephosphorylation. (1999) (2)
Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products (1991) (2)
Role of Arachidonic and Linoleic Acid Metabolites in Growth Regulation of Syrian Hamster Embryo Fibroblasts: Studies with Tumor Suppressor Gene (+) and Suppressor Gene (-) Phenotypes (1991) (2)
12S,19- and 12S,20-dihydroxyeicosanoids: novel 12S-hydroxy-5,8-cis-10-trans-14-cis-eicosatetraenoic acid metabolites formed by hydroxylation and reduction in murine lymphocytes. (1989) (2)
Detection of glutathione free radical catalyzed by prostaglandin hydroperoxidase present in intact epidermal cells (1986) (2)
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells. (2022) (2)
Metabolism of arachidonic acid by hamster trachea lack of stimulation by A23187. (1986) (2)
Enzyme induction of organic nitrates I: nitroglycerin in vivo experiments. (1972) (2)
Synthesis of tropine-labeled atropine. IV. Labeling of the 2, 3, and 4 positions of atropine from citric-14-C acid. (1968) (2)
Cloning and sequencing of prostaglandin H synthetase from rat tracheal epithelial cells: structural evidence that a TPA regulated mRNA codes for the rat ortholog of murine PHS-1. (1997) (1)
Global Gene Expression Changes by Several Phytochemicals in Human Colorectal Cancer Cell (2011) (1)
13(S)-HpODE modulates mitogenic signal transduction through enhancing the phosphorylation and association of EGF receptor with the tyrosine phosphatase SHP-2. (1999) (1)
Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. (1995) (1)
Structural requirements for enhancement of EGF-dependent DNA synthesis by oxygenated metabolites of linoleic acid. (1997) (1)
Oxidations Catalyzed by Prostaglandin H Synthase (1990) (1)
Production of Arachidonic Acid Metabolites by Alveolar Macrophages Treated with Asbestos (1985) (1)
Pulmonary biosynthesis and metabolism of prostaglandins and related substances. (1981) (1)
Alkyl and superoxide radical formation from the decomposition of fatty acid hydroperoxides by lipoxygenase: Spin trapping evidence (1990) (1)
Role of arachidonic acid and linoleic acid metabolism in epidermal growth factor initiated proliferation of Syrian hamster embryo fibroblasts. (1997) (1)
Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene during sulfite oxidation (1986) (1)
Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. (2002) (1)
510 Metabolism of chemical carcinogens by prostaglandin synthase (1983) (0)
An ESR Study of the Oxidation and Reduction of Bisulfite (Hydrated Sulfur Dioxide) in Biological Systems (1985) (0)
SYNTHESIS OF ATROPINE LABELED WITH C14 IN THE TROPINE RING AND EFFECT OF COLD ACCLIMATION ON ATROPINE METABOLISM (1967) (0)
Activation of TRPA 1 by Volatile Organic Chemicals Leading to Sensory Irritation 1 (2019) (0)
Formation of S-substituted glutathione adducts of styrene catalyzed by protaglandin H synthase: a possible new mechanism for the formation of glutathione conjugates (1986) (0)
Identification of Linoleic Acid Metabolism as a Component of the Epidermal Growth Factor Signal Transduction Pathway in BALB/c 3T3 Fibroblasts (1991) (0)
Transcriptional regulation of 15-lipoxygenase in human coloretal carcinoma cells by histone deacetylase inhibitors (1999) (0)
Carcinogenesis Involving Cyclooxygenase and Lipoxygenase (2003) (0)
Abstract 982: Transgenic expression of NSAID-activated gene-1 (NAG-1) protects mice from high fat diet-induced obesity (2011) (0)
Mechanism of inactivation of prostacyclin synthase and prostaglandin h synthase by phenyl butazone (1984) (0)
ESR Investigation of Tyrosyl Radicals of Prostaglandin H Synthase; Relation to Enzyme Catalysis (1993) (0)
The altered expression of Gab1 during neoplastic progression: A possible regulator of the altered responsiveness to growth factors and lipid mediators (1999) (0)
Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. (1980) (0)
In Memoriam: Colin F. Chignell (2008) (0)
Induction of Cyclooxygenase-2 Expression by Interleukin-1β in Human Glioma Cell Line, U87MG. Commentary (2008) (0)
Abstract B53: Proteasome inhibitor MG132 induces NAG-1 expression through activation of p38 MAPK pathway (2012) (0)
348 - The Ratio of 8-Iso-Prostaglandin F2α to Prostaglandin F2α distinguishes Enzymatic from Nonenzymatic Isoprostane Formation (2014) (0)
PKC-dependent Regulation of NAG-1 / PLAB / MIC-1 Expression in LNCaP Prostate Carcinoma Cells (2004) (0)
Studies of the fate and distribution of tem in mice. Abstr. (1976) (0)
The 8-Iso-PGF2a/PGF2a Ratio Quantitatively Measures Chemical Lipid Peroxidation in Animal Models (2015) (0)
The Role of Eicosanoids and Linoleic Acid Metabolites in Epidermal Growth Factor Dependent Cellular Proliferation (1993) (0)
Abstract 5541: The dual effects of H6D polymorphism of NAG-1/GDF15 in prostate cancer carcinogenesis (2011) (0)
Stimulation of de novo Synthesis of Prostaglandin H Synthetase (PHS) in Rat Tracheal Epithelial Cells by TPA Involves Activation of Protein Kinase C (1991) (0)
Abstract LB-338: Increased apoptosis and p53 expression in sclerotome of COX-2 transgenic embryo (2010) (0)
Prostaglandin synthetase dependent oxidation of (+)trans7,9-dihydroxy- -7,8-dihydro-benzo(a)pyrene to mutagenic metabolites in c3h/10t1/2 cells. Abstr. (1981) (0)
Effect of PPAR activators on cytokine-stimulated COX-2 induction in human colorectal carcinoma cells (1999) (0)
SynthetaseMetabolism of Diethylstilbestrol by Prostaglandin (2013) (0)
Abstract 5174: Involvement of COX-2 in p53 induction and Jnk activation following DNA damage. (2013) (0)
Drug-induced expression of NAG-1/MIC-1/PDF, a putative tumor suppressor, inhibits tumor growth (2006) (0)
hNAG‐1 increases survival by regulating metabolism and insulin/IGF‐1/mTOR signaling (LB432) (2014) (0)
The NSAID sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1 (2006) (0)
Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (0)
3,3′-diindolylmethane, a major acid condensation product of indole-3-carbinol, induce expression of NAG-1 and ATF3 in colorectal cancer cells. (2006) (0)
Metabolism of poly cyclic aromatic hydro carbons and aromatic amines to mutagenic products by prostaglandin synthetase (1982) (0)
Peroxyl radical-mediated oxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-Diol) in mouse skin (1986) (0)
NAG-1/GDF15 Exerts Anti-diabetic Effects through the Insulin Signaling Pathway (2021) (0)
Contents of volume 106 (2008) (0)
The conventional NSAID sulindac sulfide arrests ovarian cancer cell growth through NSAID-activated gene (NAG-1) (2005) (0)
The induction of apoptosis and the expressions of NAG-1 and p53 in HCT116 after irradiation (2004) (0)
15-lipoxygenase-1 expression in prostate cancer: Correlation with mutant P53 expression and histologic grade (1999) (0)
Correction: Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation (2016) (0)

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