Thomas E. Eling
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(Suggest an Edit or Addition)Thomas E. Eling's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin (2007) (811)
- The horseradish peroxidase-catalyzed oxidation of 3,5,3',5'-tetramethylbenzidine. Free radical and charge-transfer complex intermediates. (1982) (739)
- Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. (2001) (421)
- Prostaglandin H synthase and xenobiotic oxidation. (1990) (292)
- Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells. (1994) (232)
- Role of reactive oxygen species in LPS‐induced production of prostaglandin E2 in microglia (2004) (220)
- Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. (2002) (197)
- Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells (1999) (189)
- A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. (1977) (188)
- Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ (2003) (179)
- Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. (2004) (169)
- Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. (2006) (168)
- NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism (2014) (160)
- Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein (2005) (159)
- Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation* (1997) (155)
- Opposing Effects of 15-Lipoxygenase-1 and -2 Metabolites on MAPK Signaling in Prostate (2002) (147)
- Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene EGR-1* (2004) (144)
- Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. (2001) (137)
- Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene. (2002) (135)
- Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. (2002) (129)
- The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. (2013) (126)
- NSAID activated gene (NAG-1), a modulator of tumorigenesis. (2006) (126)
- Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. (1992) (125)
- Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. (2006) (125)
- Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. (2005) (125)
- Nitric Oxide Trapping of Tyrosyl Radicals Generated during Prostaglandin Endoperoxide Synthase Turnover (1998) (123)
- Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter (2001) (118)
- Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins. (1990) (117)
- Expression of 15-lipoxygenase-1 in human colorectal cancer. (1999) (117)
- Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor. (1988) (115)
- Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. (2002) (112)
- A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies. (1980) (111)
- Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. (2000) (109)
- 15-Lipoxygenase-1 Metabolites Down-regulate Peroxisome Proliferator-activated Receptor γ via the MAPK Signaling Pathway* (2001) (109)
- Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase. (1992) (108)
- Functional characterization of cyclooxygenase-2 polymorphisms. (2001) (104)
- Identification of Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway* (2004) (104)
- The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3) (2005) (103)
- Accumulation of amines in the isolated perfused rabbit lung. (1974) (102)
- Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs. (1973) (100)
- Analysis of leukotrienes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. (1984) (98)
- Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion. (1986) (97)
- Co-oxidation of benzidine by prostaglandin synthase and comparison with the action of horseradish peroxidase. (1983) (96)
- Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. (1993) (94)
- Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. (2003) (92)
- Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. (2019) (91)
- Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. (1999) (90)
- Xenobiotic metabolism by prostaglandin H synthase. (1992) (89)
- Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53‐dependent mechanism and inhibition of prostate cancer cell growth (2006) (88)
- hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling (2014) (88)
- Prostaglandin synthetase-dependent cooxidation of (+/-)-benzo(a)pyrene-7,8-dihydrodiol by human lung and other mammalian tissues. (1981) (88)
- The formation of sulfur trioxide radical anion during the prostaglandin hydroperoxidase-catalyzed oxidation of bisulfite (hydrated sulfur dioxide). (1982) (86)
- Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase. (1983) (86)
- Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation. (2015) (84)
- Changes in gene expression contribute to cancer prevention by COX inhibitors. (2006) (84)
- Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets. (2014) (83)
- Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. (1984) (82)
- Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. (2005) (82)
- Protein Kinase C-dependent Regulation of NAG-1/Placental Bone Morphogenic Protein/MIC-1 Expression in LNCaP Prostate Carcinoma Cells* (2005) (81)
- Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity* (1996) (81)
- 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. (2004) (81)
- Xenobiotic metabolism by prostaglandin endoperoxide synthetase. (1983) (80)
- Metabolism of benzo(a)pyrene to reactive intermediate(s) via prostaglandin biosynthesis. (1978) (80)
- Bioactivation of xenobiotics by prostaglandin H synthase. (1991) (79)
- Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. (2004) (79)
- Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase. (1983) (79)
- Prostaglandin removal and metabolism by isolated perfused rat lung. (1976) (77)
- The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases. (1983) (77)
- The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15 (2005) (76)
- Transcriptional Regulation of Cyclooxygenase-1 by Histone Deacetylase Inhibitors in Normal Human Astrocyte Cells* (2002) (74)
- A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L. (2006) (73)
- A novel peroxisome proliferator–activated receptor γ ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells (2006) (73)
- Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (73)
- Oxidative metabolism of diethylstilbestrol by prostaglandin synthetase. (1982) (71)
- Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. (1996) (71)
- Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. (1999) (71)
- Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis. (1991) (69)
- The effect of 15-Lipoxygenase-1 expression on cancer cells (2002) (68)
- Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells (2003) (67)
- Superoxide and peroxyl radical generation from the reduction of polyunsaturated fatty acid hydroperoxides by soybean lipoxygenase. (1991) (67)
- Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolism. (1986) (67)
- Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. (1999) (66)
- Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. (2000) (66)
- Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures. (1983) (65)
- A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. (2008) (65)
- The Linoleic Acid Metabolite, (13S)-Hydroperoxyoctadecadienoic Acid, Augments the Epidermal Growth Factor Receptor Signaling Pathway by Attenuation of Receptor Dephosphorylation (1997) (64)
- Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes. (1981) (64)
- A study of the dynamics of imipramine accumulation in the isolated perfused rabbit lung. (1975) (64)
- The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived. (1982) (63)
- Production of arachidonic acid metabolites by macrophages exposed in vitro to asbestos, carbonyl iron particles, or calcium ionophore. (1985) (63)
- Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. (1986) (62)
- Cooxidation of the clinical reagent 3,5,3'5'-tetramethylbenzidine by prostaglandin synthase. (1982) (62)
- Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. (2003) (62)
- The formation of aminopyrine cation radical by the peroxidase activity of prostaglandin H synthase and subsequent reactions of the radical. (1985) (62)
- Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. (1997) (61)
- The oxidation of arachidonic acid by the cyclooxygenase activity of purified prostaglandin H synthase: spin trapping of a carbon-centered free radical intermediate. (1986) (60)
- Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. (1990) (60)
- Mechanism of inhibition of prostaglandin H synthase by eugenol and other phenolic peroxidase substrates. (1989) (59)
- Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice (2009) (59)
- A role for phospholipids in the binding and metabolism of drugs by hepatic microsomes. Use of the fluorescent hydrophobic probe 1-anilinonaphthalene-8-sulphonate. (1971) (59)
- Separation of arachidonic acid metabolites by high-pressure liquid chromatography. (1982) (58)
- Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. (2001) (58)
- Formation of free radical metabolites in the reaction between soybean lipoxygenase and its inhibitors. An ESR study. (1989) (58)
- Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. (2002) (56)
- Resveratrol-Induced Apoptosis Is Mediated by Early Growth Response-1, Krüppel-Like Factor 4, and Activating Transcription Factor 3 (2011) (56)
- Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase. (1992) (56)
- Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. (2003) (55)
- Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1) (2007) (55)
- Metabolism of arachidonic acid by human nasal and bronchial epithelial cells. (1988) (54)
- Evidence for a one-electron mechanism of 2-aminofluorene oxidation by prostaglandin H synthase and horseradish peroxidase. (1984) (52)
- Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models. (2016) (52)
- Drug-Induced Expression of Nonsteroidal Anti-Inflammatory Drug-Activated Gene/Macrophage Inhibitory Cytokine-1/Prostate-Derived Factor, a Putative Tumor Suppressor, Inhibits Tumor Growth (2006) (52)
- Biosynthesis of prostaglandins by isolated and cultured airway epithelial cells. (1986) (51)
- Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression. (2014) (51)
- Pulmonary intravascular macrophages metabolize arachidonic acid in vitro. Comparison with alveolar macrophages. (1988) (50)
- Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen. (1986) (50)
- Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways (2005) (50)
- NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response (2013) (50)
- Arachidonic acid metabolism by isolated epidermal basal and differentiated keratinocytes from the hairless mouse. (1986) (49)
- A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L (2005) (49)
- Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. (1998) (48)
- Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1 (2005) (48)
- Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase. (1982) (47)
- The cytochrome P-450 monooxygenase system of rabbit bladder mucosa: enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene. (1985) (46)
- Prostaglandin synthetase and cytochrome P-450-dependent metabolism of (+/-)benzo(a)pyrene 7,8-dihydrodiol by enriched populations of rat Clara cells and alveolar type II cells. (1983) (46)
- Phenylbutazone-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. A new mechanism for prostaglandin H synthase-catalyzed oxidations. (1984) (46)
- Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C. (1996) (45)
- Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene via a hydroperoxide-dependent mechanism catalyzed by lipoxygenases. (1989) (45)
- The influence of environmental agents on prostaglandin biosynthesis and metabolism in the lung. Inhibition of lung 15-hydroxyprostaglandin dehydrogenase by exposure of guinea pigs to 100 per cent oxygen at atmospheric pressure. (1975) (45)
- An electron spin resonance study of the activation of benzidine by peroxidases. (1983) (45)
- Studies of the mechanisms involved in the fate of prostacyclin (PGI2) and 6-keto-PGF1alpha in the pulmonary circulation. (1978) (45)
- A free radical mechanism of prostaglandin synthase-dependent aminopyrine demethylation. (1981) (44)
- Transcriptional Regulation of Activating Transcription Factor 3 Involves the Early Growth Response-1 Gene (2005) (44)
- Evidence for a free radical mechanism of styrene-glutathione conjugate formation catalyzed by prostaglandin H synthase and horseradish peroxidase. (1986) (44)
- Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter BASAL TRANSCRIPTION IS MEDIATED BY Sp1 AND Sp3* (2001) (43)
- Detection of glutathione thiyl free radical catalyzed by prostaglandin H synthase present in keratinocytes. Study of co-oxidation in a cellular system. (1989) (43)
- Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism. (1970) (42)
- Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations. (1974) (42)
- A GATA binding site is involved in the regulation of 15‐lipoxygenase‐1 expression in human colorectal carcinoma cell line, Caco‐2 (2000) (42)
- ADPase activity of isolated perfused rat lung. (1978) (42)
- Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid. (1974) (41)
- Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1/GDF15) Expression Is Increased by the Histone Deacetylase Inhibitor Trichostatin A* (2008) (41)
- Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. (2001) (41)
- The effect of ozone exposure on rat alveolar macrophage arachidonic acid metabolism. (1991) (39)
- DNA methylation‐mediated silencing of nonsteroidal anti‐inflammatory drug‐activated gene (NAG‐1/GDF15) in glioma cell lines (2012) (38)
- Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. (2003) (36)
- COX inhibitors directly alter gene expression: role in cancer prevention? (2011) (35)
- The oxidation of N-substituted aromatic amines by horseradish peroxidase. (1989) (35)
- The pharmacodynamics of 5-hydroxytryptamine uptake and metabolism by the isolated perfused rabbit lung. (1975) (35)
- Studies on the persistence of basic amines in the rabbit lung. (1979) (35)
- Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells. (1982) (34)
- A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. (2009) (34)
- Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. (1999) (34)
- Metabolism of aromatic amines by prostaglandin H synthase. (1985) (34)
- Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis. (1982) (34)
- Lower NLRP3 Inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity (2013) (34)
- Respiratory movements alter the generation of prostacyclin and thromboxane A2 in isolated rat lungs: the influence of arachidonic acid-pathway inhibitors on the ratio between pulmonary prostacyclin and thromboxane A2. (1981) (34)
- Uptake, metabolism and efflux of methadone in "single pass" isolated perfused rabbit lungs. (1976) (33)
- Formation of unique arylamine:DNA adducts from 2-aminofluorene activated by prostaglandin H synthase. (1985) (33)
- Cellular proliferation and lipid metabolism: importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis (1994) (33)
- Arachidonic acid-dependent cooxidation. A potential pathway for the activation of chemical carcinogens in vivo. (1984) (33)
- Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung. (2018) (32)
- Peroxidase-catalyzed oxidation of (bi)sulfite: reaction of free radical metabolites of (bi)sulfite with (+/-)-7,8-dihydroxy-7, 8-dihydroxy[a]pyrene. (1988) (32)
- Prostaglandin H synthase-dependent co-oxygenation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants. (1984) (32)
- Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. (1994) (32)
- Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents. (2008) (31)
- Overexpression of 15-Lipoxygenase-1 Induces Growth Arrest through Phosphorylation of p53 in Human Colorectal Cancer Cells (2005) (31)
- Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum. (1988) (31)
- Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. (1978) (31)
- Prostaglandin H synthase-dependent mutagenic activation of benzidine in a Salmonella typhimurium Ames tester strain possessing elevated N-acetyltransferase levels. (1989) (31)
- Relative activities of retrovirally expressed murine prostaglandin synthase-1 and -2 depend on source of arachidonic acid. (1996) (30)
- Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice (2010) (30)
- Comparison of arachidonic acid metabolism by pulmonary intravascular and alveolar macrophages exposed to particulate and soluble stimuli. (1989) (29)
- Regulation of murine hematopoiesis by arachidonic acid metabolites. (1989) (29)
- Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines. (1989) (29)
- Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins. (1977) (29)
- Inhibition of pulmonary prostaglandin metabolism by exposure of animals to oxygen or nitrogen dioxide. (1979) (28)
- Ionizing Radiation Enhances the Expression of the Nonsteroidal Anti-inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells (2006) (28)
- The Role of NAG-1/GDF15 in the Inhibition of Intestinal Polyps in APC/Min Mice by Sulindac (2011) (28)
- Analysis and quantitation of splicing variants of the TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells. (1995) (28)
- Covalent binding of an intermediate(s) in prostaglandin biosynthesis to guinea pig lung microsomal protein. (1977) (27)
- Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. (1996) (27)
- Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4'-(acetylamino)biphenyl. (1992) (27)
- The formation of styrene glutathione adducts catalyzed by prostaglandin H synthase. A possible new mechanism for the formation of glutathione conjugates. (1986) (27)
- Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells (2003) (27)
- Characterization of prostaglandins by combined gas-liquid chromatography and chemical ionization mass spectrometry. (1974) (26)
- Carbon-centered free radical intermediates in the hematin- and ram seminal vesicle-catalyzed decomposition of fatty acid hydroperoxides. (1986) (26)
- Metabolism of prostaglandin endoperoxide by microsomes from human lung parenchyma and comparison with metabolites produced by pig, bovine, rat, mouse and guinea-pig. (1982) (26)
- Effect of aspirin and indomethacin on the formation of benzo(a)pyrene-induced pulmonary adenomas and DNA adducts in A/HeJ mice. (1983) (26)
- Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-beta activity through the inhibition of Smad signaling pathway. (2003) (26)
- Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism (2008) (25)
- Embryonic Expression of Cyclooxygenase-2 Causes Malformations in Axial Skeleton* (2010) (25)
- Enhanced mutagenicity of anisidine isomers in bacterial strains containing elevated N-acetyltransferase activity. (1992) (25)
- Pulmonary biosynthesis and metabolism of prostaglandins and related substances. (1984) (25)
- Separation of prostaglandins, thromboxane, hydroxy fatty acids and arachidonic acid by high pressure liquid chromatography. (1980) (25)
- Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester: mediation by protein kinase C. (1991) (24)
- Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: relationship to inhibition of prostaglandin cyclooxygenase. (1988) (24)
- Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. (1999) (23)
- 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. (2002) (23)
- Pulmonary intravascular macrophages produce prostaglandins and leukotrienes in vitro. (1988) (23)
- The interaction of a fluorescent probe with rat hepatic microsomes. (1970) (23)
- Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase. (1991) (23)
- Chemical structure of the adducts formed by the oxidation of benzidine in the presence of phenols. (1982) (23)
- The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis. (1999) (23)
- EGR1 is a novel target for AhR agonists in human lung epithelial cells. (2004) (23)
- Prostaglandin H synthase-catalyzed metabolism and DNA binding of 2-naphthylamine. (1987) (22)
- The formation of 2-aminofluorene-DNA adducts in vivo: evidence for peroxidase-mediated activation. (1989) (21)
- Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor-dependent DNA synthesis and c-myc proto-oncogene expression in Syrian hamster embryo cells. (1993) (21)
- Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. (2010) (21)
- The H6D variant of NAG‐1/GDF15 inhibits prostate xenograft growth in vivo (2012) (20)
- Arachidonic acid metabolism in respiratory epithelial cells. (1988) (20)
- Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. (1995) (20)
- Ozone inhibits endothelial cell cyclooxygenase activity through formation of hydrogen peroxide. (1987) (20)
- Studies on the covalent binding of an intermediate(s) in prostaglandin biosynthesis to tissue macromolecules. (1979) (20)
- The oxidation of 4-aminobiphenyl by horseradish peroxidase. (1992) (20)
- Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. (1985) (20)
- Ram seminal vesicle microsome-catalyzed activation of benzidine and related compounds: dissociation of mutagenesis from peroxidase-catalyzed formation of DNA-reactive material. (1988) (19)
- Arachidonic Acid-Dependent Metabolism of Chemical Carcinogens and Toxicants (1985) (19)
- Cooxidation of steroidal and non-steroidal estrogens by purified prostaglandin synthase results in a stimulation of prostaglandin formation. (1987) (19)
- Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ. (1993) (19)
- Peroxidative oxidation of bilirubin during prostaglandin biosynthesis. (1985) (19)
- Retinoid-induced differentiation regulates prostaglandin H synthase and cPLA2 expression in tracheal epithelium. (1996) (18)
- The Cyclooxygenase Inhibitor Sulindac Sulfide Inhibits EP4 Expression and Suppresses the Growth of Glioblastoma Cells (2009) (18)
- A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. (1983) (18)
- Uptake and metabolism of prostaglandins by isolated perfused lung: species comparisons and the role of plasma protein binding. (1977) (18)
- Conjugation of 15-keto-prostaglandins by glutathione S-transferases. (1978) (18)
- Modulation of c-jun and jun-B messenger RNA and inhibition of DNA synthesis by prostaglandin E2 in Syrian hamster embryo cells. (1992) (18)
- Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism. (1985) (18)
- Expression of Gab1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression (2001) (17)
- Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin β-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells (2004) (17)
- 15‐Lipoxygenase‐1 activates tumor suppressor p53 independent of enzymatic activity (2008) (17)
- Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells. (2013) (17)
- ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. (1993) (17)
- The prostaglandin H synthase-dependent activation of 2-aminofluorene to products mutagenic to S. typhimurium strains TA98 and TA98NR. (1985) (16)
- The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. (2005) (16)
- The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products. (1987) (16)
- Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase. (1990) (15)
- Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. (2002) (15)
- Macromolecular binding of the thyroid carcinogen 3-amino-1,2,4-triazole (amitrole) catalyzed by prostaglandin H synthase, lactoperoxidase and thyroid peroxidase. (1987) (15)
- Inhibition of EGF-dependent mitogenesis by prostaglandin E2 in Syrian hamster embryo fibroblasts. (1998) (15)
- Synthesis of tropine-labeled atropine. I. Micro methods for the synthesis of tropine and for its esterification with tropic acid. (1967) (15)
- Peroxidase-mediated formation of glutathione conjugates from polycyclic aromatic dihydrodiols and insecticides. (1989) (14)
- EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways. (1995) (14)
- The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice (2021) (13)
- The oxidation of the calcium probe quin2 and its analogs by prostaglandin H synthase. (1989) (13)
- Covalent binding of prostaglandins G2 and H2 to components of ram seminal vesicle microsomal fraction. (1979) (13)
- Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung (1976) (13)
- Covalent binding of intermediates formed during the metabolism of arachidonic acid by human platelet subcellular fractions. (1979) (13)
- Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase. (1996) (13)
- Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells. (1998) (13)
- Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts. (1996) (12)
- Prostaglandin H synthase-mediated bioactivation of the amino acid pyrolysate product Trp P-2. (1986) (12)
- The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association. (1999) (12)
- Arachidonic acid metabolism in normal and transformed rat tracheal epithelial cells and its possible role in the regulation of cell proliferation. (1989) (11)
- Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level (1999) (11)
- Inhibition of prostacyclin synthesis in cultured bovine aortic endothelial cells by vitamin K1. (1986) (11)
- Kinetic changes in microsomal drug metabolism with age and diphenylhydantoin treatment. (1970) (11)
- Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. (2001) (10)
- Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. (2008) (10)
- Binding of iron beads to sialic acid residues on macrophage membranes stimulates arachidonic acid metabolism. (1985) (9)
- Mechanism of 12-O-tetradecanoylphorbol-13-acetate enhanced metabolism of arachidonic acid in dog urothelial cells. (1990) (9)
- Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages (1995) (9)
- Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. (1997) (8)
- Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation (2022) (8)
- Metabolism of prostaglandin PG-F2 alpha by freshly isolated alveolar type II cells from lungs of adult male or pregnant rabbits. (1987) (8)
- Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. (1980) (7)
- Prostaglandin release and the interaction of platelets with the pulmonary vasculature of rat and guinea pig. (1980) (7)
- Synthesis of tropine-labeled atropine II. Prototype synthesis for the preparation of tropine-14C and atropine-14C from arabinose-14C. (1967) (7)
- Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation (2016) (6)
- Synthesis of rropine-labeled atropine 3. Synthesis of N-methyl-14C-tropine and N-methyl-14C-atropine. (1968) (6)
- Studies on the biosynthesis, metabolism and transport of prostaglandins by the lung (1976) (6)
- Peroxidase-mediated glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol is enhanced by benzo[a]pyrene phenols in vitro. (1992) (6)
- Prostacyclin and thromboxane A2 release in isolated rat lungs. (1982) (6)
- Activation of TRPA1 by volatile organic chemicals leading to sensory irritation. (2019) (6)
- NAG-1/GDF15 protects against streptozotocin-induced type 1 diabetes by inhibiting apoptosis, preserving beta-cell function, and suppressing inflammation in pancreatic islets (2022) (5)
- Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. (2001) (5)
- BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity (2008) (5)
- High-pressure liquid chromatography of neurotoxic phenylphosphonothioate esters and related compounds. (1980) (5)
- Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. (2008) (3)
- Prostaglandin H synthase-catalyzed ring oxygenation of 2-naphthylamine: evidence for two distinct oxidation pathways. (1995) (3)
- (t10c12-CLA) in a polygenic obese line of mice -12-conjugated linoleic acid cis -10, trans elicited by Functional genomic characterization of delipidation (2005) (3)
- Epidermal Growth Factor Regulation of Linoleic Acid Metabolism in Syrian Hamster Embryo Fibroblasts (1993) (3)
- Functional genomic characterization of polygenic obese mice fed t10, c12 conjugated linoleic acid (2004) (2)
- Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. (1991) (2)
- 13(S)-HpODE augments epidermal growth factor signal transduction by attenuating EGF receptor dephosphorylation. (1999) (2)
- Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products (1991) (2)
- Role of Arachidonic and Linoleic Acid Metabolites in Growth Regulation of Syrian Hamster Embryo Fibroblasts: Studies with Tumor Suppressor Gene (+) and Suppressor Gene (-) Phenotypes (1991) (2)
- 12S,19- and 12S,20-dihydroxyeicosanoids: novel 12S-hydroxy-5,8-cis-10-trans-14-cis-eicosatetraenoic acid metabolites formed by hydroxylation and reduction in murine lymphocytes. (1989) (2)
- Detection of glutathione free radical catalyzed by prostaglandin hydroperoxidase present in intact epidermal cells (1986) (2)
- NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells. (2022) (2)
- Metabolism of arachidonic acid by hamster trachea lack of stimulation by A23187. (1986) (2)
- Enzyme induction of organic nitrates I: nitroglycerin in vivo experiments. (1972) (2)
- Synthesis of tropine-labeled atropine. IV. Labeling of the 2, 3, and 4 positions of atropine from citric-14-C acid. (1968) (2)
- Cloning and sequencing of prostaglandin H synthetase from rat tracheal epithelial cells: structural evidence that a TPA regulated mRNA codes for the rat ortholog of murine PHS-1. (1997) (1)
- Global Gene Expression Changes by Several Phytochemicals in Human Colorectal Cancer Cell (2011) (1)
- 13(S)-HpODE modulates mitogenic signal transduction through enhancing the phosphorylation and association of EGF receptor with the tyrosine phosphatase SHP-2. (1999) (1)
- Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. (1995) (1)
- Structural requirements for enhancement of EGF-dependent DNA synthesis by oxygenated metabolites of linoleic acid. (1997) (1)
- Oxidations Catalyzed by Prostaglandin H Synthase (1990) (1)
- Production of Arachidonic Acid Metabolites by Alveolar Macrophages Treated with Asbestos (1985) (1)
- Pulmonary biosynthesis and metabolism of prostaglandins and related substances. (1981) (1)
- Alkyl and superoxide radical formation from the decomposition of fatty acid hydroperoxides by lipoxygenase: Spin trapping evidence (1990) (1)
- Role of arachidonic acid and linoleic acid metabolism in epidermal growth factor initiated proliferation of Syrian hamster embryo fibroblasts. (1997) (1)
- Epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene during sulfite oxidation (1986) (1)
- Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. (2002) (1)
- 510 Metabolism of chemical carcinogens by prostaglandin synthase (1983) (0)
- An ESR Study of the Oxidation and Reduction of Bisulfite (Hydrated Sulfur Dioxide) in Biological Systems (1985) (0)
- SYNTHESIS OF ATROPINE LABELED WITH C14 IN THE TROPINE RING AND EFFECT OF COLD ACCLIMATION ON ATROPINE METABOLISM (1967) (0)
- Activation of TRPA 1 by Volatile Organic Chemicals Leading to Sensory Irritation 1 (2019) (0)
- Formation of S-substituted glutathione adducts of styrene catalyzed by protaglandin H synthase: a possible new mechanism for the formation of glutathione conjugates (1986) (0)
- Identification of Linoleic Acid Metabolism as a Component of the Epidermal Growth Factor Signal Transduction Pathway in BALB/c 3T3 Fibroblasts (1991) (0)
- Transcriptional regulation of 15-lipoxygenase in human coloretal carcinoma cells by histone deacetylase inhibitors (1999) (0)
- Carcinogenesis Involving Cyclooxygenase and Lipoxygenase (2003) (0)
- Abstract 982: Transgenic expression of NSAID-activated gene-1 (NAG-1) protects mice from high fat diet-induced obesity (2011) (0)
- Mechanism of inactivation of prostacyclin synthase and prostaglandin h synthase by phenyl butazone (1984) (0)
- ESR Investigation of Tyrosyl Radicals of Prostaglandin H Synthase; Relation to Enzyme Catalysis (1993) (0)
- The altered expression of Gab1 during neoplastic progression: A possible regulator of the altered responsiveness to growth factors and lipid mediators (1999) (0)
- Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. (1980) (0)
- In Memoriam: Colin F. Chignell (2008) (0)
- Induction of Cyclooxygenase-2 Expression by Interleukin-1β in Human Glioma Cell Line, U87MG. Commentary (2008) (0)
- Abstract B53: Proteasome inhibitor MG132 induces NAG-1 expression through activation of p38 MAPK pathway (2012) (0)
- 348 - The Ratio of 8-Iso-Prostaglandin F2α to Prostaglandin F2α distinguishes Enzymatic from Nonenzymatic Isoprostane Formation (2014) (0)
- PKC-dependent Regulation of NAG-1 / PLAB / MIC-1 Expression in LNCaP Prostate Carcinoma Cells (2004) (0)
- Studies of the fate and distribution of tem in mice. Abstr. (1976) (0)
- The 8-Iso-PGF2a/PGF2a Ratio Quantitatively Measures Chemical Lipid Peroxidation in Animal Models (2015) (0)
- The Role of Eicosanoids and Linoleic Acid Metabolites in Epidermal Growth Factor Dependent Cellular Proliferation (1993) (0)
- Abstract 5541: The dual effects of H6D polymorphism of NAG-1/GDF15 in prostate cancer carcinogenesis (2011) (0)
- Stimulation of de novo Synthesis of Prostaglandin H Synthetase (PHS) in Rat Tracheal Epithelial Cells by TPA Involves Activation of Protein Kinase C (1991) (0)
- Abstract LB-338: Increased apoptosis and p53 expression in sclerotome of COX-2 transgenic embryo (2010) (0)
- Prostaglandin synthetase dependent oxidation of (+)trans7,9-dihydroxy- -7,8-dihydro-benzo(a)pyrene to mutagenic metabolites in c3h/10t1/2 cells. Abstr. (1981) (0)
- Effect of PPAR activators on cytokine-stimulated COX-2 induction in human colorectal carcinoma cells (1999) (0)
- SynthetaseMetabolism of Diethylstilbestrol by Prostaglandin (2013) (0)
- Abstract 5174: Involvement of COX-2 in p53 induction and Jnk activation following DNA damage. (2013) (0)
- Drug-induced expression of NAG-1/MIC-1/PDF, a putative tumor suppressor, inhibits tumor growth (2006) (0)
- hNAG‐1 increases survival by regulating metabolism and insulin/IGF‐1/mTOR signaling (LB432) (2014) (0)
- The NSAID sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1 (2006) (0)
- Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (0)
- 3,3′-diindolylmethane, a major acid condensation product of indole-3-carbinol, induce expression of NAG-1 and ATF3 in colorectal cancer cells. (2006) (0)
- Metabolism of poly cyclic aromatic hydro carbons and aromatic amines to mutagenic products by prostaglandin synthetase (1982) (0)
- Peroxyl radical-mediated oxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (BP-7,8-Diol) in mouse skin (1986) (0)
- NAG-1/GDF15 Exerts Anti-diabetic Effects through the Insulin Signaling Pathway (2021) (0)
- Contents of volume 106 (2008) (0)
- The conventional NSAID sulindac sulfide arrests ovarian cancer cell growth through NSAID-activated gene (NAG-1) (2005) (0)
- The induction of apoptosis and the expressions of NAG-1 and p53 in HCT116 after irradiation (2004) (0)
- 15-lipoxygenase-1 expression in prostate cancer: Correlation with mutant P53 expression and histologic grade (1999) (0)
- Correction: Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation (2016) (0)
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