Takashi Hashimoto
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Takashi Hashimoto's Degrees
- PhD Biochemistry University of Tokyo
- Masters Molecular Biology University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Takashi Hashimoto's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- PEROXISOMAL β-OXIDATION AND PEROXISOME PROLIFERATOR–ACTIVATED RECEPTOR α: An Adaptive Metabolic System (2001) (804)
- Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)* (1998) (794)
- Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting* (2000) (435)
- Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. (2001) (372)
- Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). (1998) (364)
- Structure and regulation of rat long-chain acyl-CoA synthetase. (1990) (331)
- Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. (1992) (323)
- The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily. (1990) (317)
- Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. (1986) (312)
- Amino-terminal presequence of the precursor of peroxisomal 3-ketoacyl-CoA thiolase is a cleavable signal peptide for peroxisomal targeting. (1991) (286)
- Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase. (1992) (232)
- Tea Catechin Suppresses Adipocyte Differentiation Accompanied by Down-regulation of PPARγ2 and C/EBPα in 3T3-L1 Cells (2004) (210)
- Purification and properties of acyl-CoA oxidase from rat liver. (1980) (206)
- Peroxisomal and Mitochondrial Fatty Acid β-Oxidation in Mice Nullizygous for Both Peroxisome Proliferator-activated Receptor α and Peroxisomal Fatty Acyl-CoA Oxidase (1999) (204)
- Acyl-CoA oxidase of rat liver: a new enzyme for fatty acid oxidation. (1978) (199)
- Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. (1991) (194)
- Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus (1989) (193)
- INDIVIDUAL PEROXISOMAL βT‐OXIDATION ENZYMES * (1982) (185)
- Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di-(i-ethylhexyl)phthalate. (1978) (181)
- The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes. (1980) (179)
- Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. (1987) (175)
- Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase. (1987) (172)
- Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. (2005) (168)
- Peroxisomal beta oxidation system of rat liver. Copurification of enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase. (1979) (163)
- Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. (1998) (160)
- Molecular basis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of the major disease-causing mutation in the alpha-subunit of the mitochondrial trifunctional protein. (1994) (158)
- Changes in cellular levels of ATP and its catabolites in ischemic rat liver. (1982) (153)
- Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients. (1995) (152)
- Molecular Cloning of cDNA Encoding Rat Very Long-chain Acyl-CoA Synthetase* (1996) (147)
- Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. (2003) (145)
- A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase. (1993) (143)
- Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. (2008) (136)
- Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator (2002) (134)
- Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. (1987) (132)
- The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice (2009) (130)
- Properties of mitochondria and peroxisomal enoyl-CoA hydratases from rat liver. (1980) (128)
- Identity of long-chain acyl-coenzyme A synthetase of microsomes, mitochondria, and peroxisomes in rat liver. (1985) (128)
- Insertion of the 70-kDa Peroxisomal Membrane Protein into Peroxisomal Membranes in Vivo and in Vitro(*) (1996) (128)
- Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liver. (1980) (127)
- Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase. (1986) (127)
- Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. (1990) (125)
- Carboxyl-terminal consensus Ser-Lys-Leu-related tripeptide of peroxisomal proteins functions in vitro as a minimal peroxisome-targeting signal. (1992) (117)
- Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. (2004) (116)
- Peroxisomal β-oxidation enzyme proteins in the Zellweger syndrome (1985) (115)
- Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver. (1983) (114)
- Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis. (1999) (113)
- Identification of Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency in Three Patients Previously Diagnosed with Long-Chain Acyl-CoA Dehydrogenase Deficiency (1993) (112)
- Characterization of the signal peptide at the amino terminus of the rat peroxisomal 3-ketoacyl-CoA thiolase precursor. (1994) (112)
- In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells. (2008) (112)
- D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder. (1997) (111)
- Anti‐obesity actions of green tea: Possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis‐related transcription factors (2004) (111)
- Purification and properties of rat liver acyl-CoA dehydrogenases and electron transfer flavoprotein. (1981) (107)
- Biosynthesis and intracellular transport of enzymes of peroxisomal beta-oxidation. (1984) (105)
- Commercial-scale Preparation of Biofunctional Fucoxanthin from Waste Parts of Brown Sea Algae Laminalia japonica (2008) (103)
- Absence of Spontaneous Peroxisome Proliferation in Enoyl-CoA Hydratase/l-3-Hydroxyacyl-CoA Dehydrogenase-deficient Mouse Liver (1999) (102)
- Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits. (1996) (99)
- Subcellular distribution of the enzymes of the fatty acyl-CoA beta-oxidation system and their induction by di(2-ethylhexyl)phthalate in rat liver. (1979) (97)
- Intestinal Anti-Inflammatory Activity of Lentinan: Influence on IL-8 and TNFR1 Expression in Intestinal Epithelial Cells (2013) (97)
- Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein. (1994) (96)
- Acyl-Coenzyme A synthetase and fatty acid oxidation in rat liver peroxisomes. (1978) (95)
- Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. (2004) (94)
- The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A. (1989) (92)
- Biosynthesis and maturation of peroxisomal beta-oxidation enzymes in fibroblasts in relation to the Zellweger syndrome and infantile Refsum disease. (1986) (92)
- Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. (2006) (87)
- Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract (2011) (86)
- Isolation and structural characterization of the rat acyl-CoA oxidase gene. (1987) (86)
- Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. (1997) (84)
- Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver. (1981) (83)
- Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid beta-oxidation multienzyme complex. Structural and functional relationships to other mitochondrial and peroxisomal beta-oxidation enzymes. (1993) (81)
- Two mitochondrial 3-hydroxyacyl-CoA dehydrogenases in bovine liver. (1996) (81)
- Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells. (2010) (81)
- Less Extrahepatic Induction of Fatty Acid β-Oxidation Enzymes by PPARα (2000) (78)
- Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. (1999) (77)
- Mitochondrial trifunctional protein deficiency. Catalytic heterogeneity of the mutant enzyme in two patients. (1994) (76)
- Deoxyribonucleic acid analyses of five families with familial inherited thyroid stimulating hormone deficiency. (1990) (72)
- Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase. (1996) (71)
- Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein. (1994) (71)
- Reversal of severe hypertrophic cardiomyopathy and excellent neuropsychologic outcome in very-long-chain acyl-coenzyme A dehydrogenase deficiency. (1998) (71)
- Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients. (1995) (69)
- Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver. (1998) (69)
- N-acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics. (1991) (67)
- Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency. (1990) (66)
- Immunocytochemical localization of D-amino acid oxidase in the central clear matrix of rat kidney peroxisomes. (1986) (66)
- Thyromimetic effect of peroxisomal proliferators in rat liver. (1991) (64)
- cDNA cloning of a neural visinin-like Ca(2+)-binding protein. (1992) (61)
- Purification and properties of rat liver peroxisomal very-long-chain acyl-CoA synthetase. (1996) (61)
- Immunoelectron microscopy of tissues processed by rapid freezing and freeze-substitution fixation without chemical fixatives: application to catalase in rat liver hepatocytes. (1990) (60)
- Peroxisomal β‐Oxidation: Enzymology and Molecular Biology a (1996) (58)
- Medium Chain 3-Ketoacyl-Coenzyme A Thiolase Deficiency: A New Disorder of Mitochondrial Fatty Acid β-Oxidation (1997) (58)
- Immunocytochemical localization of peroxisomal enzymes in human liver biopsies. (1987) (57)
- Structural organization of the gene for rat enoyl-CoA hydratase:3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. (1987) (55)
- Artepillin C in Brazilian propolis induces G0/G1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells (2005) (54)
- Molecular cloning and sequence analysis of the cDNA for rat mitochondrial enoyl-CoA hydratase (1989) (54)
- Effects of sodium 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) on fatty acid oxidation in fibroblasts from patients with peroxisomal diseases. (1991) (54)
- Mutation analysis of very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency: identification and characterization of mutant VLCAD cDNAs from four patients. (1996) (54)
- Developmental immunohistochemistry of catalase in the human brain (1991) (53)
- Decrease in mitochondrial levels of adenine nucleotides and concomitant mitochondrial dysfunction in ischemic rat liver. (1983) (53)
- Defect in biosynthesis of mitochondrial acetoacetyl-coenzyme A thiolase in cultured fibroblasts from a boy with 3-ketothiolase deficiency. (1988) (52)
- Kinetic studies on the reaction mechanism and the citrate activation of liver acetyl coenzyme A carboxylase. (1971) (52)
- Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators. (1981) (52)
- Thiolase involved in bile acid formation. (1998) (49)
- Cell-free synthesis of the enzymes of peroxisomal β-oxidation (1982) (49)
- Molecular analysis of peroxisomal beta-oxidation enzymes in infants with Zellweger syndrome and Zellweger-like syndrome: further heterogeneity of the peroxisomal disorder. (1988) (49)
- Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. (2000) (49)
- Overexpression of Peroxisome Proliferator-activated Receptor-α (PPARα)-regulated Genes in Liver in the Absence of Peroxisome Proliferation in Mice Deficient in both l- and d-Forms of Enoyl-CoA Hydratase/Dehydrogenase Enzymes of Peroxisomal β-Oxidation System* (2003) (49)
- Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria. (1997) (48)
- Epidemiology of X-linked adrenoleukodystrophy in Japan (2002) (47)
- Genes for the Human Mitochondrial Trifunctional Protein α- and β-Subunits Are Divergently Transcribed from a Common Promoter Region* (1999) (46)
- Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver (2004) (45)
- Deficient activities and proteins of peroxisomal beta-oxidation enzymes in infants with Zellweger syndrome. (1986) (45)
- Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency. (1992) (45)
- Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase. (1989) (44)
- Molecular basis of β‐ketothiolase deficiency: Mutations and polymorphisms in the human mitochondrial acetoacetyl‐coenzyme a thiolase gene (1995) (43)
- Newly Identified Forms of Electron Transfer Flavoprotein Deficiency in Two Patients with Glutaric Aciduria Type II (1991) (42)
- Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation (2009) (42)
- Characterization of N93S, I312T, and A333P missense mutations in two Japanese families with mitochondrial acetoacetyl‐CoA thiolase deficiency (1998) (42)
- Purification and properties of rat D-3-hydroxyacyl-CoA dehydratase: D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. (1996) (42)
- Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase. (1994) (42)
- Short photoirradiation induces flavonoid synthesis and increases its production in postharvest vegetables. (2012) (41)
- The inducible fatty acid oxidation system in mammalian peroxisomes (1984) (41)
- Light microscopic immunocytochemical demonstration of peroxisomal enzymes in epon sections (2004) (41)
- Turnover of enzymes of peroxisomal β-oxidation in rat liver (1980) (40)
- Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. (1997) (39)
- Peroxisomal β-Oxidation Enzymes (1999) (39)
- Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects. (2013) (39)
- alpha-Amanitin inhibits the oxidation of long chain fatty acids in mouse liver. (1981) (39)
- Biosynthesis of enzymes of peroxisomal beta-oxidation. (1982) (38)
- Biochemical and Morphologic Aspects of Peroxisomes in the Human Rectal Mucosa: Diagnosis of Zellweger Syndrome Simplified by Rectal Biopsy (1988) (37)
- Acyl-CoA ligases from rat brain microsomes: an immunochemical study. (1988) (36)
- Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice (2002) (36)
- Purification and properties of carnitine acetyltransferase from rat liver. (1983) (36)
- Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase. (1980) (35)
- Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency. (1994) (35)
- Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase. (1994) (35)
- Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase. (1993) (35)
- Immunoelectron Microscopy of Peroxisomal Enzymes; Their Substructural Association and Compartmentalization in Rat Kidney Peroxisomes (1987) (35)
- Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. (2007) (35)
- Evidence for a structural mutation (347Ala to Thr) in a German family with 3-ketothiolase deficiency. (1991) (34)
- Immunocytochemical localization of fatty acid metabolizing heat-stable and heat-labile enoyl-coenzyme A (CoA) hydratases in liver and renal cortex. (1983) (34)
- Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice (2010) (34)
- Yellow tea is more potent than other types of tea in suppressing liver toxicity induced by carbon tetrachloride in rats (2007) (34)
- Effects of di-(2-ethylhexyl)phthalate administration on carbohydrate and fatty acid metabolism in rat liver. (1978) (33)
- Immunoelectron microscopic study of a new D-amino acid oxidase-immunoreactive subcompartment in rat liver peroxisomes. (1991) (33)
- Transport of proteins into mitochondrial matrix. Evidence suggesting a common pathway for 3-ketoacyl-CoA thiolase and enzymes having presequences. (1985) (32)
- Novel subtype of peroxisomal acyl-CoA oxidase deficiency and bifunctional enzyme deficiency with detectable enzyme protein: identification by means of complementation analysis. (1994) (32)
- Proliferation of peroxisomes and induction of peroxisomal beta-oxidation enzymes in rat hepatoma H4IIEC3 by ciprofibrate. (1990) (32)
- Effects of Combined Administration of Quercetin, Rutin, and Extract of White Radish Sprout Rich in Kaempferol Glycosides on the Metabolism in Rats (2006) (31)
- Zellweger-like syndrome with detectable hepatic peroxisomes: a variant form of peroxisomal disorder. (1988) (31)
- Peroxisomal beta-oxidation enzyme proteins in adrenoleukodystrophy: distinction between X-linked adrenoleukodystrophy and neonatal adrenoleukodystrophy. (1987) (31)
- cDNA cloning of rat liver 2,4-dienoyl-CoA reductase. (1990) (30)
- Induction of peroxisomal beta-oxidation enzymes in primary cultured rat hepatocytes by clofibric acid. (1985) (30)
- Immunocytochemical localization of urate oxidase, fatty acyl-CoA oxidase, and catalase in bovine kidney peroxisomes. (1988) (29)
- Peroxisomal acyl-coenzyme A oxidase is a rate-limiting enzyme in a very-long-chain fatty acid beta-oxidation system. (1994) (29)
- Comparison of Enzymes of Lipid β-Oxidation in Peroxisomes and Mitochondria (1987) (29)
- Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells. (1997) (29)
- Identification and characterization of two enhancers of the human albumin gene. (1992) (28)
- Complementation study of peroxisome-deficient disorders by immunofluorescence staining and characterization of fused cells (1992) (28)
- Genomic DNA organization of human mitochondrial very-long-chain acyl-CoA dehydrogenase and mutation analysis. (1995) (28)
- Biosynthesis of enzymes of rat‐liver mitochondrial β‐oxidation (1984) (27)
- Post-translational import of 3-ketoacyl-CoA thiolase into rat liver peroxisomes in vitro. (1994) (27)
- A second isoform of 3-ketoacyl-CoA thiolase found in Caenorhabditis elegans, which is similar to sterol carrier protein x but lacks the sequence of sterol carrier protein 2. (1997) (27)
- Heterogeneity of Defects in Mitochondrial Acetoacetyl-CoA Thiolase Biosynthesis in Fibroblasts from Four Patients with 3-Ketothiolase Deficiency (1989) (27)
- Hepatotoxic action of a poisonous mushroom, Amanita abrupta in mice and its toxic component. (1986) (27)
- Quantification and Localization of Fucoidan in Laminaria japonica Using a Novel Antibody (2009) (27)
- Peroxisomal localization of the immunoreactive beta-oxidation enzymes in a neonate with a beta-oxidation defect. Pathological observations in liver, adrenal cortex and kidney. (1991) (26)
- Development of a method to remove cyanogen glycosides from flaxseed meal (2007) (26)
- Synergistic effects of food colors on the toxicity of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in primary cultured rat hepatocytes. (2000) (26)
- Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3‐L1 adipocytes (2008) (26)
- Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system. (2003) (25)
- Molecular basis of 3-ketothiolase deficiency: identification of an AG to AC substitution at the splice acceptor site of intron 10 causing exon 11 skipping. (1992) (25)
- F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity (2016) (25)
- Energy-independent protection of the oxidative phosphorylation capacity of mitochondria against anoxic damage by ATP and its non-metabolizable analogs. (1985) (24)
- Demonstration of desmosomal antigens by electron microscopy using cryofixed and cryosubstituted skin with silver-enhanced gold probe. (1994) (24)
- A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood (2013) (24)
- Peroxisomal β-oxidation enzymes (2007) (24)
- Induction of acyl-CoA dehydrogenases and electron transfer flavoprotein and their roles in fatty acid oxidation in rat liver mitochondria. (1981) (24)
- Rhizomelic chondrodysplasia punctata: biochemical studies of peroxisomes isolated from cultured skin fibroblasts. (1991) (24)
- Isolation and characterization of the rat catalase-encoding gene. (1990) (24)
- Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon (2006) (23)
- A missense mutation in the RING finger motif of PEX2 protein disturbs the import of peroxisome targeting signal 1 (PTS1)-containing protein but not the PTS2-containing protein. (2000) (23)
- Induction of peroxisomal beta-oxidation by the administration of acetylsalicylic acid. (1981) (23)
- A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine. (2016) (23)
- Binding of nonsteroidal antiinflammatory drugs to the alpha-subunit of the trifunctional protein of long chain fatty acid oxidation. (1998) (22)
- Immunotitration Analysis of Cytosolic Acetoacetyl-Coenzyme A Thiolase Activity in Human Fibroblasts (1996) (22)
- The effect of di(ethylhexyl)phthalate on fatty acid oxidation and carnitine palmitoyltransferase in various rat tissues. (1990) (21)
- The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation (2014) (21)
- (−)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones (2015) (21)
- Molecular cloning of cDNA for rat liver catalase. (1984) (21)
- Effects of ethyl p-chlorophenoxyisobutyrate on carbohydrate and fatty acid metabolism in rat liver. (1975) (20)
- A formation mechanism for 8-hydroxy-2'-deoxyguanosine mediated by peroxidized 2'-deoxythymidine. (2008) (20)
- Biochemical Analysis in Peroxisomal Disorders (1987) (20)
- Relationship between structure and substrate-chain-length specificity of mitochondrial very-long-chain acyl-coenzyme A dehydrogenase. (1998) (20)
- Immunohistochemical localization of mitochondrial fatty acid β-oxidation enzymes in Müller cells of the retina (2010) (20)
- Identification of three novel frameshift mutations (83delAT, 754insCT, and 435 + 1G to A) of mitochondrial acetoacetyl‐coenzyme A thiolase gene in two Swiss patients with CRM‐negative β‐ketothiolase deficiency (1997) (20)
- Kinetics of intramolecular acyl migration of 1beta-O-acyl glucuronides of (R)- and (S)-2-phenylpropionic acids. (2001) (19)
- Prenatal Diagnosis and Neonatal Monitoring of a Fetus with Glutaric Aciduria Type II Due to Electron Transfer Flavoprotein (β-Subunit) Deficiency (1991) (19)
- Immunocytochemical localization of peroxisomal β‐oxidation enzymes in human fetal liver (1990) (19)
- Identification of beta-oxidation enzymes among peroxisomal polypeptides. Increase in Coomassie blue-stainable protein after clofibrate treatment. (1982) (18)
- Stereoselective internal acyl migration of 1beta-O-acyl glucuronides of enantiomeric 2-phenylpropionic acids. (2000) (18)
- Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: high frequency of the G1528C mutation with no apparent correlation with the clinical phenotype (1995) (18)
- Infantile Refsum disease: deficiency of catalase-containing particles (peroxisomes), alkyldihydroxyacetone phosphate synthase and peroxisomal β-oxidation enzyme proteins (1986) (18)
- Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. (2008) (18)
- Changes in aerobic and anaerobic ATP-synthesizing activities in hypoxic mouse brain. (1988) (18)
- Immunoblot detection of enzyme proteins of peroxisomal β‐oxidation in fibroblasts, amniocytes, and chorionic villous cells. Possible marker for prenatal diagnosis of Zellweger's syndrome (1988) (18)
- Immunoelectron microscopic evidence for organ differences in the composition of peroxisome-specific membrane polypeptides among three rat organs: liver, kidney, and small intestine. (1991) (17)
- Major Peroxisomal Membrane Polypeptides Are Synthesized in Cultured Skin Fibroblasts from Patients with Zellweger Syndrome (1989) (17)
- Formation of the enzyme complex in mitochondria is required for function of trifunctional beta-oxidation protein. (1996) (17)
- The 70-kDa Peroxisomal Membrane Protein (1992) (17)
- Riboflavin deficiency and β-oxidation systems in rat liver (1982) (16)
- Artemisia princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells via Glucose Transporter 4 Translocation (2010) (16)
- A sensitive assay of acyl-coenzyme A oxidase by coupling with beta-oxidation multienzyme complex. (1994) (16)
- Mitochondrial acetoacetyl‐coenzyme a thiolase gene: A Novel 68‐bp deletion involving 3′ splice site of intron 7, causing exon 8 skipping in a caucasian patient with β‐ketothiolase deficiency (1995) (16)
- Molecular cloning and expression of a gene for a factor which stabilizes formation of inhibitor-mitochondrial ATPase complex from Saccharomyces cerevisiae. (1988) (16)
- Immunocytochemical detection of peroxisomal β-oxidation enzymes in cryostat and paraffin sections of human post mortem liver (2005) (15)
- The effect of tryptophan administration on fatty acid synthesis in the liver of the fasted normal rat. (1974) (15)
- Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes. (1998) (15)
- Catalytic and FAD-binding Residues of Mitochondrial Very Long Chain Acyl-Coenzyme A Dehydrogenase* (1998) (15)
- Metabolic conversion of dietary quercetin from its conjugate to active aglycone following the induction of hepatocarcinogenesis in fisher 344 rats. (2008) (14)
- Antioxidant defence mechanism of the skin against UV irradiation: Study of the role of catalase using acatalasaemia fibroblasts (1994) (14)
- 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces apoptosis in rat splenocytes and thymocytes by different mechanisms. (2000) (13)
- Biosynthesis and turnover of carnitine acetyltransferase in rat liver. (1983) (13)
- STEREOSPECIFIC FORMATION OF (24R, 25R)-3α, 7α, 12α, 24-TETRAHYDROXY-5β-CHOLESTAN-26-OIC ACID CATALYZED WITH A PEROXISOMAL BIFUNCTIONAL D-3-HYDROXYACYL-CoA DEHYDRATASE/D-3-HYDROXYACYL-CoA DEHYDROGENASE (1997) (13)
- Separation of stereoisomers of C27-bile acid CoA esters by liquid chromatography and its application to the study of the stereospecificities of D- and L-bifunctional proteins in bile acid biosynthesis (1998) (12)
- Functional expression of rat peroxisomal acyl-CoA oxidase in Spodoptera frugiperda cells. (1994) (12)
- Influence of Storage Conditions on Immunomodulating Activities in Lentinus edodes (Berk.)Sing. (Agaricales s.l., Basidiomycetes) (1999) (12)
- Molecular analysis of peroxisomal beta-oxidation enzymes in infants with peroxisomal disorders indicates heterogeneity of the primary defect. (1989) (12)
- Correction by Gene Expression of Biochemical Abnormalities in Fibroblasts from Zellweger Patients (1996) (12)
- Light and electron microscopic localization of l-alpha-hydroxyacid oxidase in rat kidney revealed by immunocytochemical techniques (2004) (11)
- Reduction of beta-oxidation capacity of rat liver mitochondria by feeding orotic acid. (1982) (11)
- 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces caspase-dependent apoptosis in mononuclear cells. (2001) (10)
- Immunocytochemical localization of two peroxisomal enzymes of lipid β-oxidation in specific granules of rat eosinophils (2004) (10)
- Synthesis of (±)-Sundiversifolide Based on Lewis Acid-Mediated Claisen Rearrangement (2007) (10)
- Cow's milk increases the activities of human nuclear receptors peroxisome proliferator-activated receptors alpha and delta and retinoid X receptor alpha involved in the regulation of energy homeostasis, obesity, and inflammation. (2009) (10)
- Peroxisomal beta-oxidation enzyme proteins in the Zellweger syndrome. (1985) (10)
- Post-mortem visualization of peroxisomes in rat and in human liver (2005) (10)
- Identification of three novel frameshift mutations (83delAT, 754insCT, and 435 + 1G to A) of mitochondrial acetoacetyl-coenzyme A thiolase gene in two Swiss patients with CRM-negative beta-ketothiolase deficiency. (1997) (10)
- The heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells. (2001) (9)
- Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis (2001) (9)
- Resistance to erucic acid as a selectable marker for peroxisomal activity: Isolation of revertants of an infantile Refsum disease cell line (1994) (9)
- Two distinct long-chain-acyl-CoA synthetases in guinea pig Harderian gland. (1996) (9)
- cDNA cloning of mitochondrial Δ3, Δ2-enoyl-CoA isomerase of rat liver (1992) (9)
- Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1 (2018) (8)
- Glutaric aciduria type II: autopsy study of a case with electron-transferring flavoprotein dehydrogenase deficiency. (1990) (8)
- A riboflavin-responsive lipid storage myopathy due to multiple acyl-CoA dehydrogenase deficiency: An adult case (1994) (8)
- [beta-Ketothiolase deficiency]. (1988) (8)
- Biochemical and Immunochemical Study of Seven Families with 3-Ketothiolase Deficiency: Diagnosis of Heterozygotes Using Immunochemical Determination of the Ratio of Mitochondrial Acetoacetyl-CoA Thiolase and 3-Ketoacyl-CoA Thiolase Proteins (1993) (8)
- A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice (2017) (7)
- Molecular cloning of cDNA for rat mitochondrial 3-oxoacyl-CoA thiolase. (1986) (7)
- Modification of gelsolin with 4-fluoro-7-nitrobenz-2-oxa-1,3-diazole. (1991) (7)
- Synthesis, crystal structures, spectral, electrochemical and magnetic properties of di-µ-phenoxido-bridged dinuclear copper(II) complexes with N-salicylidene-2-hydroxybenzylamine derivatives: axial coordination effect of dimethyl sulphoxide molecule (2014) (7)
- Enhancement of Anti-inflammatory and Anti-allergic Activities with Combination of Luteolin and Quercetin in in vitro Co-culture System (2017) (6)
- Biochemical Effects of Amanita muscaria Extract in Mice (1983) (6)
- Prenatal diagnosis of peroxisomal D-3-hydroxyacyl-CoA dehydratase / D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency (1999) (6)
- Synthetic studies on basidifferquinones: the first synthesis of (±)-basidifferquinone C (2008) (6)
- Detection of Biomarkers for Apoptosis in Rat Liver after Perfusion with 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) (2000) (6)
- Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism (2000) (6)
- The abnormality of peroxisomal membrane proteins in Zellweger syndrome (1987) (6)
- Molecular cloning of cDNA for human mitochondrial acetoacetyl-CoA thiolase and molecular analysis of 3-ketothiolase deficiency (1990) (6)
- Lipid peroxides as endogenous oxidants forming 8-oxo-guanosine and lipid-soluble antioxidants as suppressing agents (2016) (6)
- Effect of tryptophan on fatty acid synthesis in rat liver (1973) (6)
- 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes (2004) (5)
- Inhibition of Neutrophil Chemotaxis by a Monoclonal Antibody (TM316) (1988) (5)
- Antitumor Polysaccharides from Edible Mushrooms and Immunomodulating Action Against Murine Macrophages (2001) (5)
- Molecular cloning of cDNA for rat mitochondrial 3-hydroxyacyl-CoA dehydrogenase. (1986) (5)
- Suppressive EŠect of Polysaccharides from the Edible and Medicinal Mushrooms , Lentinus edodes and Agaricus blazei , on the Expression of Cytochrome P 450 s in Mice (2003) (5)
- Effect of neutrophil activating substances on intracellular generation of phagocyte chemiluminescence by means of luminol-bound microspheres. (1988) (5)
- Turnover of enzymes of peroxisomal beta-oxidation in rat liver. (1980) (4)
- Biochemical Effects of Amanita virosa Extract on the Components and Enzymes in the Liver and Blood of Mice (1981) (4)
- Stereospecific formation of (24R,25R)-3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid catalyzed with a peroxisomal bifunctional D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase. (1997) (4)
- Immobilization of fatty acyl-CoA synthetase: effect on its stability and substrate specificity. (1986) (4)
- Intramitochondrial distribution of three acyl-CoA dehydrogenases in rat liver parenchymal cells revealed by quantitative immunoelectron microscopy. (1985) (4)
- Immunochemical studies of cultured fibroblasts from a patient with 3-ketothiolase deficiency (1988) (4)
- Further analysis of mutant thiolase protein in fibroblasts from a Japanese boy with 3-ketothiolase deficiency. (1992) (4)
- Post-mortem visualization in human liver of peroxisomes in rat and (1990) (4)
- Apoptosis in the thymus after intraperitoneal injection of rats with Trp‐P‐1 (2002) (4)
- Biosynthesis of peroxisomal β-oxidation enzymes in infants with zellweger syndrome (1986) (3)
- Hydrolytic cleavage of pyroglutamyl-peptide bond. II. Effects of amino acid residue neighboring the pGlu moiety. (1996) (3)
- Cloning and Structural Analysis of the Genes for Peroxisomal β-Oxidation Enzymes (1987) (3)
- Inhibition of neutrophil and monocyte functions by the monoclonal antibody TM2. (1988) (3)
- Immunochemical analysis of the peroxisomal beta-oxidation enzymes in rat and human heart and skeletal muscle and in skeletal muscle of Zellweger patients. (1991) (3)
- Assignment1 of human fatty-acid-Coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization (1998) (3)
- Effects of Clitocybe clavipes Extract on the Components and Enzymes Related to Ethanol Metabolism in Mice (1986) (3)
- Biochemical Effects of Poisonous Mushrooms Suspected of Causing Cholera-like Symptoms in Mice (1982) (3)
- A new variant of glutaric aciduria type II: Deficiency of β-subunit of electron transfer flavoprotein (1990) (3)
- Peroxisomal localization of the immunoreactiveβ-oxidation enzymes in a neonate with aβ-oxidation defect (2005) (3)
- Immunochemical and biochemical studies of fatty acid oxidation in fibroblasts of Zellweger and X-linked adrenoleukodystrophy patients. (1991) (3)
- A Frequent Drinking of Green Tea Lowers the Levels of Endogenous Oxidative Stress in Small Intestines, Erythrocytes and Kidneys in Rats (2006) (3)
- Biochemical studies on lymphoblastoid cells with inherited N-acetyl-glucosamine 1-phosphotransferase deficiency (I-cell disease). (1988) (3)
- Immunocytochemical localization of L-α-hydroxyacid oxidase in dense bar of dumb-bell-shaped peroxisomes of monkey kidney (1995) (2)
- A Possible Mechanism That Flavonoids Exert Anticarcinogenesis with Activation of β-Glucuronidase in Cancerous Tissues (2008) (2)
- [Biochemical effects in mice and cytotoxicity in a cultured cell line of the extract of Amanita abrupta]. (1984) (2)
- Diagnosis of Zellweger syndrome by rectal biopsy: immunoblot of peroxisomal beta-oxidation enzyme and activity of dihydroxyacetone phosphate acyltransferase in rectal mucosa. (1988) (2)
- Identification of TaqI polymorphism in the mitochondrial acetoacetyl-CoA thiolase gene and familial analysis of 3-ketothiolase deficiency (1992) (2)
- The effect of tryptophan administration on fatty acid synthesis in the livers of rats under various nutritional conditions. (1975) (2)
- Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency. (1991) (2)
- Practical assay method of cytosolic acetoacetyl-CoA thiolase by rapid release of cytosolic enzymes from cultured lymphocytes using digitonin. (1998) (2)
- Impaired Maturation of Peroxisomal ß-oxidation Enzymes in Fibroblasts from Patients with the Zellweger Syndrome and Infantile Refsum Disease (1986) (2)
- cDNA cloning of mitochondrial delta 3, delta 2-enoyl-CoA isomerase of rat liver. (1992) (2)
- Innermembrane association of three mitochondrial β-oxidation enzymes revealed by immunoelectron microscopic technique (2004) (2)
- Molecular basis of 3-ketothiolase deficiency: Detection of gene mutations and expression of mutant cDNAs of mitochondrial acetoacetyl-CoA thiolase (1992) (1)
- Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells (2003) (1)
- Electron microscopic immunocytochemistry on the colocalization of ATP synthase and cytochrome P-450 of side chain cleavage enzymes in mitochondria of rat and bovine adrenal cortical cells. (1993) (1)
- 3-Ketothiolase deficiency: Heterogeneity in a defect of mitochondrial acetoacetyl-CoA thiolase biosynthesis in fibroblasts from four patients (1989) (1)
- 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) Is Incorporated into Rat Splenocytes, Thymocytes, and Hepatocytes Through Monoamine Transporters and Induces Apoptosis (2002) (1)
- A genetic disorder due to the deficiency of the peroxisomal β-oxidation enzyme 3-oxoacyl-CoA thiolase (1987) (1)
- Antitumor Polysaccharides from Edible and Medicinal Mushrooms and Immunomodulating Action Against Murine Macrophages (2001) (1)
- Effect of triamcinolone administration on content of flavins in rabbit liver. (1976) (1)
- Innermembrane association of three mitochondrial β-oxidation enzymes revealed by immunoelectron microscopic technique (2004) (1)
- Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity (2017) (1)
- Specific granules of rat eosinophils contain peroxisomal acyl-CoA oxidase: possible involvement in production of H2O2 (1984) (1)
- Amino acid and nucleotide sequences of human peroxisomal enoyl-CoA hydratase : 3-hydroxyacyl-CoA dehydrogenase cDNA (1998) (1)
- Immunoelectron Microscopic Localization of Peroxisomal Enzymes in the Fibrillar Structures of Rat Liver Peroxisomes Induced by Administration of Acetylsalicylic Acid. (1995) (1)
- First Synthesis of (±)-Basidifferquinone C, an Inducer for Fruiting-Body Formation in Polyporus arcularius (2009) (1)
- [Relationship between chemotaxis and surface antigen of neutrophils]. (1989) (1)
- Lentina nfro mshiitak emushroo m(Lentinus edodes )suppresse sexpressio no fcytochrome P450 1A subfamily in the mouse liver (2004) (0)
- Synergistic Anti-Inflammatory Activity of Luteolin and Some Polyphenoles in In Vitro Co-Culture System Composed of Caco-2 and RAW264.7 Cells (2014) (0)
- A Tryptophan Pyrolysis Product, 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) but Not Its Metabolite Induces Apoptosis in Primary Cultured Rat Hepatocytes: Induction of CYP 1A Interfaces Trp-P-1-Induced Apoptosis (2003) (0)
- Artepillin C Inhibits Cell Proliferation by Cell Cycle Arrest at G0/G1 Phase Accompanied by Up-Regulation of p27Kip1 in Human Hepatoma HepG2 Cells (2021) (0)
- Rreliminar : ) , Cbmmunication Tryptophan Pyrolysis Products , Trp-P-1 and Trp-P-2 Induce Apoptosis in Primary Cultured Rat Hepatocytes (2018) (0)
- Overexpression of PPAR (cid:68) regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D- forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal (cid:69) -oxidation system* (2003) (0)
- The Heterogeneity of Leber’s Congenital Amaurosis (1989) (0)
- Inhibition of 6-Methylsulfinylhexyl Isothiocyanate for Cell Cycle Progression in Quiescent JB6 Cells Stimulated with Fetal Bovine Serum, Accompanied by Suppression of Cyclin A2 Expression (2021) (0)
- Addendum to the minireview Chromosome microdissection: a brief overview (1997) (0)
- Thermoactive analyzer as a procedure to measure neutrophilic heat generation induced by various stimulators. (1986) (0)
- Molecular characterization of the mouse very-long-chain acyl-CoA dehydrogenase gene (1997) (0)
- Kobe University Repository : Kernel タイトル Tit le In vit ro model to est imate gut inflammation using co-cultured Caco-2 and RAW 264 . 7 cells (2018) (0)
- Kobe University Repository : Kernel タイトル Tit le The distribut ion and accumulat ion of fucoxanthin and its metabolites after oral administrat ion in mice 著者 (2017) (0)
- JSem 3-Amino-1 , 4-dimethyl-5 ll-pyrido [ 4 , 3-b ] indole ( Trp-P-1 ) Is Incorporated into Rat Splenocytes , Thyrnocytes , and Hepatocytes Through Monoamine Transporters and Ind " ces Apoptosis (2018) (0)
- Indentification of β‐oxidation enzymes among peroxisomal polypeptides (2001) (0)
- Metabolic significance and expression of Caenorhabditis elegans type II 3-oxoacyl-CoA thiolase (2007) (0)
- Synthetic Studies on Basidifferquinones: The First Synthesis of (.+‐.)‐Basidifferquinone C. (2008) (0)
- Absorption of dietary licorice [Glycyrrhiza glabra] isoflavan glabridin to blood circulation in rats (2007) (0)
- Further Analysis of Mutant Thiolase in Fibroblasts from a Japanese Boy 3-Ketothiolase Deficiency Protein (2006) (0)
- Use of Pulverized Cold-pressed Flaxseed Meal as a Food Ingredient and Antioxidative Potency of Flaxseed Lignans (2007) (0)
- Assignment of the gene for very-long-chain acyl-CoA dehydrogenase (Acadvl) to mouse chromosome band 11B2-B5 by in situ hybridization. (1997) (0)
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What Schools Are Affiliated With Takashi Hashimoto?
Takashi Hashimoto is affiliated with the following schools:
