Tadashi Inagami

Q: What Schools Are Affiliated With Tadashi Inagami

Tadashi Inagami is affiliated with the following schools: University of Texas Medical Branch, Ehime University, Kansai Medical University, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Yokohama City University, Osaka University, University of Zurich

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Tadashi Inagami

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Tadashi Inagami's Degrees

PhD Pharmacology University of Tokyo

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Tadashi Inagami's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

International union of pharmacology. XXIII. The angiotensin II receptors. (2000) (2130)
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. (1993) (710)
Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells* (1998) (604)
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. (2004) (460)
The primary structure of epidermal growth factor. (1972) (459)
Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. (1989) (424)
Identification of two subtypes in the rat type I angiotensin II receptor (1992) (416)
Role of endothelin in cyclosporine-induced glomerular dysfunction. (1990) (376)
Atrial natriuretic factor in rat hypothalamus, atria and plasma: determination by specific radioimmunoassay. (1984) (356)
Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. (1999) (348)
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. (1998) (337)
Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. (1997) (324)
Angiotensin II Type 2 Receptor Is Essential for Left Ventricular Hypertrophy and Cardiac Fibrosis in Chronic Angiotensin II–Induced Hypertension (2001) (308)
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy (2002) (302)
Identification of an Essential Signaling Cascade for Mitogen-activated Protein Kinase Activation by Angiotensin II in Cultured Rat Vascular Smooth Muscle Cells (1996) (298)
Elements of a paracrine tubular renin-angiotensin system along the entire nephron. (1999) (287)
Activation of MAPKs by Angiotensin II in Vascular Smooth Muscle Cells (2001) (283)
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. (2006) (281)
Rat atrial natriuretic factor: complete amino acid sequence and disulfide linkage essential for biological activity. (1984) (269)
Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. (1989) (264)
Hypercholesterolemia Stimulates Angiotensin Peptide Synthesis and Contributes to Atherosclerosis Through the AT1A Receptor (2004) (264)
Nonproteolytic Activation of Prorenin Contributes to Development of Cardiac Fibrosis in Genetic Hypertension (2006) (256)
Atrial natriuretic factor. (1989) (255)
Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. (2007) (249)
Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence (1984) (241)
Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. (1992) (240)
Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. (2000) (239)
Proposed update of angiotensin receptor nomenclature. (1995) (226)
Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. (1999) (218)
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors (2021) (212)
Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2. (1977) (207)
A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy (2003) (205)
Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats. (1986) (202)
Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. (1986) (197)
Isolation and characterization of renin-like enzymes from mouse submaxillary glands. (1972) (189)
Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. (1998) (188)
Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. (2000) (187)
Involvement of PYK2 in angiotensin II signaling of vascular smooth muscle cells. (1999) (182)
Endothelium as an endocrine organ. (1995) (181)
Isolation of Preferentially Expressed Genes in the Kidneys of Hypertensive Rats (1991) (180)
Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity. (1992) (179)
Immunocytochemical localization of atrial natriuretic factor in the kidney, adrenal medulla, pituitary, and atrium of rat. (1985) (178)
Angiotensin II–Induced Cardiac Hypertrophy and Hypertension Are Attenuated by Epidermal Growth Factor Receptor Antisense (2002) (177)
Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. (1999) (174)
Two distinct forms of receptors for atrial natriuretic factor in bovine adrenocortical cells. Purification, ligand binding, and peptide mapping. (1987) (173)
The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells* (1998) (169)
Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols. (1989) (160)
Developmental expression of renal angiotensin II receptor genes in the mouse. (1995) (153)
Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase (2000) (151)
Rat atrial natriuretic factor. Purification and vasorelaxant activity. (1983) (151)
Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. (2006) (149)
Participation of adenosine 5′‐triphosphate in the activation of membrane‐bound guanylate cyclase by the atrial natriuretic factor (1987) (149)
Changes in the content of atrial natriuretic factor with the progression of hypertension in spontaneously hypertensive rats. (1985) (144)
Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. (2006) (144)
Inhibition of pressure natriuresis in mice lacking the AT2 receptor. (2000) (144)
Immunochemical identification of renin in rat brain and distinction from acid proteases (1978) (143)
Synthetic rat atrial natriuretic factor inhibits in vitro and in vivo renin secretion in rats. (1985) (142)
Identification of linoleic and oleic acids as endogenous Na+,K+-ATPase inhibitors from acute volume-expanded hog plasma. (1985) (139)
Renal physiology of the mouse. (2000) (137)
G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor* (2005) (136)
The intrarenal renin-angiotensin system in autosomal dominant polycystic kidney disease. (2004) (135)
Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease. (1992) (133)
Molecular biology of angiotensin II receptors: an overview. (1994) (132)
Signal-Crosstalk Between Rho/ROCK and c-Jun NH2-Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II (2005) (131)
Design of a diffractometer and flow cell system for X-ray analysis of crystalline proteins with applications to the crystal chemistry of ribonuclease-S. (1967) (131)
Angiotensin induces the urinary peristaltic machinery during the perinatal period. (1998) (131)
Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis. (1992) (130)
Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. (1992) (128)
The angiotensin II type 1 receptor and receptor-associated proteins (2001) (126)
Beta-adrenoceptor-mediated release of angiotensin II from mesenteric arteries. (1986) (126)
Isolation of pure and stable renin from hog kidney. (1975) (125)
Distinct Mechanisms of Receptor and Nonreceptor Tyrosine Kinase Activation by Reactive Oxygen Species in Vascular Smooth Muscle Cells: Role of Metalloprotease and Protein Kinase C-δ (2003) (122)
Angiotensin II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney. (1981) (120)
Involvement of Reactive Oxygen Species in the Activation of Tyrosine Kinase and Extracellular Signal-Regulated Kinase by Angiotensin II. (2000) (120)
Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. (1992) (119)
AT1A, AT1B, and AT2angiotensin II receptor subtype gene expression in rat brain (1995) (116)
Antiangiogenic Effect of Angiotensin II Type 2 Receptor in Ischemia-Induced Angiogenesis in Mice Hindlimb (2002) (116)
(Pro)Renin Receptor–Mediated Activation of Mitogen-Activated Protein Kinases in Human Vascular Smooth Muscle Cells (2007) (116)
Angiotensin II Type 2 Receptor Blockade Increases Bone Mass* (2009) (115)
Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1) (*) (1995) (114)
Atrial natriuretic factor inhibits vasopressin secretion from rat posterior pituitary. (1985) (113)
Atrial natriuretic peptide and brain natriuretic peptide coexist in the secretory granules of human cardiac myocytes. (1991) (113)
Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins. (1981) (112)
Rat atrial natriuretic factor: isolation, structure and biological activities of four major peptides. (1984) (110)
Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor (1999) (110)
Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. (1996) (109)
Pure Renin. Isolation from hog kidney and characterization. (1977) (108)
A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production. (1985) (108)
A Domain for G Protein Coupling in Carboxyl-terminal Tail of Rat Angiotensin II Receptor Type 1A* (1997) (106)
Human renal renin. Complete purification and characterization. (1980) (106)
Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog. (1989) (106)
Angiotensin II regulates renin gene expression. (1990) (104)
Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells. (1992) (103)
Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. (1996) (103)
Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex: guanylate cyclase-linked and cyclase-free receptors. (1987) (102)
Nonspecific catalyses by alpha-chymotrypsin and trypsin. (1960) (100)
Ligand-independent trans-Activation of the Platelet-derived Growth Factor Receptor by Reactive Oxygen Species Requires Protein Kinase C-δ and c-Src* (2002) (99)
Molecular biology and signaling of angiotensin receptors: an overview. (1999) (99)
Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases. (1999) (99)
Renin and prorenin in hog brain: Ubiquitous distribution and high concentration in the pituitary and pineal (1980) (98)
Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis. (1994) (98)
Targeted Deletion of Angiotensin II Type 2 Receptor Caused Cardiac Rupture After Acute Myocardial Infarction (2002) (96)
Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). (1992) (95)
A radioimmunoassay for the direct measurement of renin in mice and its application to submaxillary gland and kidney studies. (1974) (94)
Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1 (1993) (94)
Localization of renin in trophoblasts in human chorion laeve at term pregnancy. (1981) (93)
The rat angiotensin II AT1A receptor couples with three different signal transduction pathways. (1992) (93)
Immunocytochemical localization of renin and kallikrein in the rat renal cortex. (1986) (93)
Local generation and release of angiotensin II in peripheral vascular tissue. (1988) (93)
A review of mutagenesis studies of angiotensin II type 1 receptor, the three‐dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism (1997) (92)
Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries. (1986) (92)
Alterations in Atrial and Plasma Atrial Natriuretic Factor (ANF) Content During Development of Hypoxia-Induced Pulmonary Hypertension in the Rat (1986) (92)
Endothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats. (1993) (90)
Immunohistochemical localization of renin in luteinizing hormone-producing cells of rat pituitary. (1981) (89)
Intrarenal localization of angiotensin II type 1 receptor mRNA in the rat. (1993) (89)
Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. (1988) (89)
Effects of changes in water-sodium balance on levels of atrial natriuretic factor messenger RNA and peptide in rats. (1985) (89)
The distribution of angiotensin II AT1 receptor subtype mRNA in the rat brain (1992) (87)
Flow-Dependent Dilation Mediated by Endogenous Kinins Requires Angiotensin AT2 Receptors (2004) (86)
Mapping of G protein coupling sites of the angiotensin II type 1 receptor. (1995) (86)
Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. (1999) (85)
Identification of phenylthiohydantoins of amino acids by thin-layer chromatography on a plastic-backed silica-gel plate. (1972) (84)
Evidence for intracellular formation of angiotensins: coexistence of renin and angiotensin-converting enzyme in Leydig cells of rat testis. (1984) (83)
The genomic organization of human angiotensin II type 1 receptor. (1994) (83)
Regulation of Calcium-sensitive Tyrosine Kinase Pyk2 by Angiotensin II in Endothelial Cells (2000) (83)
Long‐term blood pressure telemetry in AT2 receptor‐disrupted mice (2000) (83)
Rat renin: purification and characterization. (1978) (82)
Synthesis of atrial natriuretic peptides and studies on structural factors in tissue specificity. (1984) (81)
Isolation of completely inactive plasma prorenin and its activation by kallikreins. A possible new link between renin and kallikrein. (1979) (81)
ANGIOTENSIN RECEPTORS: MOLECULAR BIOLOGY AND SIGNALLING (1999) (80)
Renin exists in human adrenal tissue. (1983) (80)
Identification of two types of specific endothelin receptors in rat mesangial cell. (1989) (78)
Differential regulation of angiotensin II receptor subtypes in rat kidney by low dietary sodium. (1995) (74)
Amino acid sequence of mouse submaxillary gland renin. (1982) (74)
Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. (1993) (74)
Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats. (1982) (73)
Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats (1992) (73)
The structure of ribonuclease-S at 6 A resolution. (1967) (73)
Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method (1992) (72)
Regulation of renin angiotensins by gonadotropic hormones in cultured murine Leydig tumor cells. Release of angiotensin but not renin. (1986) (72)
Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. (1996) (72)
Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. (2003) (72)
Atrial natriuretic factor receptor on cultured Leydig tumor cells: ligand binding and photoaffinity labeling. (1986) (72)
Isolation and characterization of a specific endogenous Na+,K+-ATPase inhibitor from bovine adrenal. (1988) (71)
Increased concentration of plasma immunoreactive atrial natriuretic factor in Dahl salt sensitive rats with sodium chloride-induced hypertension. (1986) (70)
Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells. (1998) (70)
Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. (2007) (70)
Pituitary-dependent renin-like immunoreactivity in the rat testis. (1983) (69)
Requirement of Ca2+and PKCδ for Janus Kinase 2 Activation by Angiotensin II: Involvement of PYK2 (2002) (69)
Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type 1A promoter. (1995) (68)
Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation. (2002) (68)
Chromosomal assignment of human and rat hypertension candidate genes: type 1 angiotensin II receptor genes and the SA gene (1993) (68)
Interaction of the Adaptor Protein Shc and the Adhesion Molecule Cadherin* (1997) (67)
The inhibition of progesterone secretion and the regulation of cyclic nucleotides by atrial natriuretic factor in gonadotropin responsive murine Leydig tumor cells. (1985) (67)
Lysophosphatidylcholine Activates Extracellular Signal-Regulated Kinases 1/2 Through Reactive Oxygen Species in Rat Vascular Smooth Muscle Cells (2002) (66)
Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. (1998) (65)
Synthesis and presence of atrial natriuretic factor in rat ventricle. (1987) (65)
Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy (2001) (65)
Juxtaglomerular Cells Grown as Monolayer Cell Culture Contain Renin, Angiotensin I‐Converting Enzyme, and Angiotensins I and II/III (1982) (65)
Commercially Available Angiotensin II At2 Receptor Antibodies Are Nonspecific (2013) (65)
Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells. (1993) (64)
Antisera to atrial natriuretic factor reduces urinary sodium excretion and increases plasma renin activity in rats. (1985) (64)
High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells. (1989) (63)
Immunohistological evidence for renin in human endocrine tissues. (1985) (62)
Atrial natriuretic factor regulates steroidogenic responsiveness and cyclic nucleotide levels in mouse Leydig cells in vitro. (1986) (62)
Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT1 and AT2 receptors (2006) (61)
Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation (1994) (61)
The structure of ribonuclease-S at 3.5 A resolution. (1967) (60)
Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4–Deficient Mice (2013) (60)
Native form of renin in the kidney. (1977) (60)
Intracellular Signaling in Rat Cultured Vascular Smooth Muscle Cells: Roles of Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase on Tumor Necrosis Factor-α Production. (1999) (60)
Atrial natriuretic polypeptide inhibits cortisol secretion as well as aldosterone secretion in vitro from human adrenal tissue. (1987) (59)
Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. (1993) (59)
The genomic organization of the rat angiotensin II receptor AT1B. (1994) (59)
Rat atrial natriuretic factor suppresses proopiomelanocortin-derived peptides secretion from both anterior and intermediate lobe cells and growth hormone release from anterior lobe cells of rat pituitary in vitro. (1986) (59)
PYK2/CAKβ Represents a Redox-Sensitive Tyrosine Kinase in Vascular Smooth Muscle Cells☆ (2000) (58)
N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor. (2001) (58)
Reperfusion enhances the local release of endothelin after regional myocardial ischemia. (1994) (58)
Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid‐induced hypertension (1994) (57)
Ultrastructural immunocytochemical localization of renin and angiotensin II in the juxtaglomerular cells of the ischemic kidney in experimental renal hypertension. (1984) (56)
Further studies on the existence of a sensitizing factor to pressor agents in hypertension. (1975) (56)
Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling. (2003) (55)
Hyporeninemic normoaldosteronism in severe autonomic failure. (1993) (55)
Glomerular renin synthesis and storage in the remnant kidney in the rat. (1991) (55)
Photoaffinity labeling of atrial natriuretic factor receptor in bovine and rat adrenal cortical membranes. (1985) (55)
Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells. (1992) (54)
Endothelin-1 receptor antagonist: effects on endothelin- and cyclosporine-treated mesangial cells. (1992) (54)
The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice. (2000) (54)
Localization of AT2 angiotensin II receptor gene expression in rat brain by in situ hybridization histochemistry. (1996) (54)
Increased gene expression of components of the renin–angiotensin system in glomeruli of genetically hypertensive rats (2000) (54)
Rat kidney renin and cathepsin D: purification and comparison of properties. (1983) (54)
Atrial natriuretic factor selectively increases renal blood flow in conscious spontaneously hypertensive rats. (1984) (54)
New signaling mechanism of angiotensin II in neuroblastoma neuro-2A cells: activation of soluble guanylyl cyclase via nitric oxide synthesis. (1993) (53)
Purification of high molecular weight forms of renin from hog kidney. (1977) (53)
Cloning, expression and regulation of angiotensin II receptors. (1994) (53)
Disulfide bridges in extracellular domains of angiotensin II receptor type IA (1995) (53)
The trypsin-catalyzed hydrolysis of benzoyl-L-arginine ethyl ester. I. The kinetics in dioxane-water mixtures. (1960) (53)
Development of Hypertension and Kidney Hypertrophy in Transgenic Mice Overexpressing ARAP1 Gene in the Kidney (2006) (52)
THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. I. INHIBITION BY ALKYL AMMONIUM IONS. (1964) (52)
Molecular Forms of Atrial Natriuretic Factor in Normal and Failing Human Myocardium (1993) (51)
Characterization of pure human renal renin. Evidence for a subunit structure. (1987) (51)
Renin in angiolymphoid hyperplasia with eosinophilia. Its possible effect on vascular proliferation. (1986) (51)
Renin exists in high concentration in the adrenal gland of the rat (1981) (51)
Inhibition of protein kinase C prevents rapid desensitization of type 1B angiotensin II receptor. (1995) (51)
Renin in rat and mouse brain: immunohistochemical identification and localization. (1980) (50)
Atrial natriuretic factor and hypertension. A review and metaanalysis. (1991) (50)
Specific receptor-mediated stimulation of progesterone secretion and cGMP accumulation by rat atrial natriuretic factor in cultured human granulosa-lutein (G-L) cells. (1987) (49)
Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomy. (1991) (49)
Cloning and characterization of a short variant of the corticotropin-releasing factor receptor subtype from rat amygdala. (1999) (49)
NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats. (2007) (48)
Regulation of vascular angiotensin release. (1993) (48)
Immunoreactive renin in mouse adrenal gland. Localization in the inner cortical region. (1984) (47)
Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. (1994) (47)
Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. (2002) (47)
Immunohistochemical localization of renin in mouse brain (1980) (47)
Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells. (1995) (47)
Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor. (2000) (46)
Prorenin has high affinity multiple binding sites for (pro)renin receptor. (2009) (46)
Cellular expression of angiotensin type-1 receptor mRNA in the kidney. (1993) (46)
Effects of targeted disruption of the mouse angiotensin II type 2 receptor gene on stress‐induced hyperthermia (1999) (46)
Solubilization and identification of human placental endothelin receptor. (1989) (46)
Cellular localization of angiotensin type 1 receptor and angiotensinogen mRNAs in the subfornical organ of the rat brain (1993) (46)
Does Plasma Immunoreactive Ouabain Originate From the Adrenal Gland? (1994) (45)
KINETIC STUDIES OF BROMELAIN CATALYSIS. (1963) (45)
Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II. (1999) (45)
THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. 3. ACTIVATION OF THE CATALYTIC SITE OF TRYPSIN BY ALKYLAMMONIUM IONS IN THE HYDROLYSIS OF ACETYLGLYCINE ETHYL ESTER. (1964) (45)
Identification of two cardiac glycosides as Na(+)-pump inhibitors in rat urine and diet. (1994) (45)
Direct visualization of renin-cell distribution in preglomerular vascular trees dissected from rat kidney. (1993) (44)
Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF-beta receptor without participation of PDGF-alpha receptor in vascular smooth muscle cells. (1993) (44)
Renin in glioblastoma multiforme and its role in neovascularization. (1988) (44)
Cloning, expression and regulation of angiotensin II receptors. (1992) (43)
Specific Antibody to Human Renal Renin and Its Cross-Reactivity with Inactive Human Plasma Prorenin (1980) (43)
Lysophosphatidylcholines containing polyunsaturated fatty acids were found as Na+, K+-ATPase inhibitors in acutely volume-expanded hog. (1987) (43)
Immunoreactive α-human atrial natriuretic polypeptide in human plasma (1986) (43)
Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A. (2002) (42)
HS-142-1, a novel nonpeptide atrial natriuretic peptide (ANP) antagonist, blocks ANP-induced renal responses through a specific interaction with guanylyl cyclase-linked receptors. (1992) (42)
Regional increase of cyclic GMP by atrial natriuretic factor in rat brain: markedly elevated response in spontaneously hypertensive rats. (1986) (42)
Evidence for alkylphosphorylation of tyrosyl residues of stem bromelain by diisopropylphosphorofluoridate. (1965) (42)
Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin. (2011) (42)
Regional distribution of renin and angiotensinogen in the brain of normotensive (WKY) and spontaneously hypertensive (SHR) rats (1985) (42)
Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion. (1993) (42)
'Decoy peptide' region (RIFLKRMPSI) of prorenin prosegment plays a crucial role in prorenin binding to the (pro)renin receptor. (2009) (41)
Genetic deletion of AT2 receptor antagonizes angiotensin II-induced apoptosis in fibroblasts of the mouse embryo. (1998) (41)
Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis. (2009) (41)
The renin-angiotensin system. (1994) (41)
Localization of kallikrein in the rat kidney and its anatomical relationship to renin. (1982) (41)
Severe endothelial injury in a renal transplant patient receiving cyclosporine. (1990) (40)
Detection of renin mRNA in mouse testis by hybridization with renin cDNA probe. (1984) (40)
Pyk2/CAKβ Tyrosine Kinase Activity-mediated Angiogenesis of Pulmonary Vascular Endothelial Cells* (2002) (40)
Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin II but not by adrenocorticotropin. (1988) (40)
Brain renin from bovine anterior pituitary. Isolation and properties. (1982) (39)
Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely (2011) (39)
Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia (2009) (39)
Release of immunoreactive atrial natriuretic factor from rat hypothalamus in vitro. (1986) (39)
Aliskiren binds to renin and prorenin bound to (pro)renin receptor in vitro (2010) (39)
Increased AT(1) receptor expression and mRNA in kidney glomeruli of AT(2) receptor gene-disrupted mice. (2001) (38)
Cyclosporine promotes glomerular endothelin binding in vivo. (1991) (38)
A memorial to Robert Tiegerstedt: the centennial of renin discovery. (1998) (38)
Recent progress in molecular and cell biological studies of angiotensin receptors. (1995) (38)
Characterization of the active site of mouse submaxillary gland renin. (1980) (37)
Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2 (2012) (37)
A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells. (1992) (37)
Kallikrein-kinin and renin-angiotensin systems in rat renal lymph. (1984) (37)
Purification and characterization of rat striatal tyrosine hydroxylase. Comparison of the activation by cyclic AMP-dependent phosphorylation and by other effectors. (1985) (37)
Novel Role of Protein Kinase C-&dgr; Tyr311 Phosphorylation in Vascular Smooth Muscle Cell Hypertrophy by Angiotensin II (2008) (36)
Intracellular Signaling of Angiotensin II-induced p70 S6 Kinase Phosphorylation at Ser411 in Vascular Smooth Muscle Cells (1999) (36)
Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds. (2017) (36)
A high level of CCAAT-enhancer binding protein-delta expression is a major determinant for markedly elevated differential gene expression of the platelet-derived growth factor-alpha receptor in vascular smooth muscle cells of genetically hypertensive rats. (1999) (36)
Plasma human atrial natriuretic factor in cirrhosis and ascites with and without functional renal failure. (1988) (35)
Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. (1995) (35)
Ontogeny of renin immunoreactive cells in the human kidney (2004) (35)
Expression of Components of the Renin-angiotensin System in Autosomal Recessive Polycystic Kidney Disease (2005) (35)
Identification of a peptidase which processes atrial natriuretic factor precursor to its active form with 28 amino acid residues in particulate fractions of rat atrial homogenate. (1987) (35)
Increased Angiotensin II AT1 Receptor Expression in Paraventricular Nucleus and Hypothalamic-Pituitary-Adrenal Axis Stimulation in AT2 Receptor Gene Disrupted Mice (2002) (35)
Participation of an acidic group in the chymotrypsin catalysis. (1969) (34)
Application of immunochemical methods to the identification and characterization of rat kidney inactive renin. (1985) (34)
Atrial Natriuretic Factor as a Volume Regulator (1994) (34)
Growth and partial differentiation of presumptive human cardiac myoblasts in culture (1989) (33)
Atrial natriuretic factor is released from rat hypothalamus in vitro. (1986) (33)
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isoform expression. (1995) (33)
Immunohistochemical localization of renin in the human kidney. (1982) (32)
Purification of human renin. (1978) (32)
Inhibition of AT1 Receptor Internalization by Concanavalin A Blocks Angiotensin II-induced ERK Activation in Vascular Smooth Muscle Cells (2000) (32)
Generation of angiotensinogen by cultured neuroblastoma and glioma cells (1986) (32)
Specific endogenous Na, K-ATPase inhibitor purified from bovine adrenal. (1987) (32)
Demonstration of renin activity in purified rat Leydig cells: evidence for the existence of an endogenous inactive (latent) form of enzyme. (1984) (32)
Vascular and tubular renin in the kidneys of mice (2004) (32)
Localization of components of the renin-angiotensin system within the kidney. (1986) (31)
3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells (2001) (31)
Renin and angiotensinogen expression during the evolution of diabetes. (1992) (31)
Antagonism or Synergism (2006) (31)
Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor. (1994) (31)
Association of a polymorphism at the 5′‐region of the angiotensin II type 1 receptor with hypertension (2000) (30)
Definitive evidence for similarity in the active site of renin and acidic protease. (1974) (30)
An affinity column for renin. (1973) (30)
Effects of synthetic atrial natriuretic factor in the isolated perfused rat kidney. (1985) (30)
Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. (1999) (30)
Glucocorticoid induction of rat angiotensin II type 1A receptor gene promoter. (1994) (30)
Human plasma inactive renin: purification and activation by proteases. (1982) (30)
Evidence for the existence of des-Asp1-angiotensin II in human uterine and adrenal tissues. (1985) (29)
Definitive evidence for renin in rat brain by affinity chromatographic separation from protease. (1978) (29)
Rapid and large-scale purification and characterization of renin from mouse submaxillary gland. (1982) (29)
Atrioactivase, a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. Purification and characterization. (1988) (29)
The N, O-diacetylmuramidase of Chalaropsis species. V. The complete amino acid sequence. (1975) (29)
Renin in anterior pituitary, pineal, and neuronal cells of mouse brain. immunohistochemical localization (1980) (29)
Signal transduction of betacellulin in growth and migration of vascular smooth muscle cells. (2004) (29)
Angiotensin AT2 Receptor Contributes towards Gender Bias in Weight Gain (2013) (29)
INTERMEDIATE MOLECULAR WEIGHT RENIN AND RENIN-BINDING PROTEIN(S) IN THE HOG KIDNEY (1980) (29)
Renin and Inactive Renin in Human Amnion at Term Pregnancy (1982) (29)
Localization and Characterization of a Short Isoform of the Corticotropin-Releasing Factor Receptor Type 2α (CRF2α-tr) in the Rat Brain (2001) (28)
Coexistence of renin and angiotensin II in epitheloid cell secretory granules of rat kidney (2004) (28)
Salutary role for angiotensin in partial urinary tract obstruction. (2000) (28)
Three distinct forms of atrial natriuretic factor receptors: kidney tubular epithelium cells and vascular smooth muscle cells contain different types of receptors. (1987) (28)
The dominant role of the prosegment of prorenin in determining the rate of activation by acid or trypsin: studies with molecular chimeras. (2000) (28)
Angiotensin II Receptors AT1 and AT2 (1997) (28)
An electrophilic mechanism in the chymotrypsin-catalyzed hydrolysis of anilide substrates. (1965) (28)
Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensin II. (2000) (28)
Beyond the G protein: the saga of the type 2 angiotensin II receptor. (2005) (27)
Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice (2005) (27)
Regulation of ANG II-receptor subtype and its gene expression in adrenal gland. (1996) (27)
Qualitative and quantitative analyses of (pro)renin receptor in the medium of cultured human umbilical vein endothelial cells (2011) (27)
New signal transduction mechanisms of atrial natriuretic factor: inhibition of phosphorylation of protein kinase C and A 240 kDa protein in adrenal cortical plasma membrane by cGMP dependent and independent mechanisms. (1987) (27)
Effect of alkyl guanidines and alkyl amines on trypsin catalysis (1968) (27)
Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. (2001) (27)
Evidence for a completely inactive renin zymogen in the kidney by affinity chromatographic isolation. (1980) (26)
Isolation of renin-rich rat kidney cells. (1987) (26)
Induction of renin activity by gonadotropic hormones in cultured Leydig tumor cells. (1985) (26)
Antibody-Sensitive Renin of Adrenal and Resistance Vessels is Markedly Elevated in Spontaneously Hypertensive Rats (1982) (26)
Translational regulation of angiotensin II type 1A receptor. Role of upstream AUG triplets. (1996) (26)
Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis. (2002) (26)
Calmodulin antagonists stimulate renin release from isolated rat glomeruli. (1983) (26)
Totally inactive renin zymogen and different forms of active renin in hog brain tissues. (1981) (26)
Pure human inactive renin. Evidence that native inactive renin is prorenin. (1989) (26)
Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells. (2002) (26)
Renin in the rat pituitary coexists with angiotensin II and depends on testosterone. (1986) (26)
Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney. (1991) (25)
Role of the angiotensin II type-2 receptor in the mouse central nervous system. (1999) (25)
Immunohistochemical localization of renin in renal tumors. (1987) (25)
Angiotensin II Receptor (1994) (25)
Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome. (1994) (25)
Renin in the brain and neuroblastoma cells: an endogenous and intracellular system. (1982) (25)
Effect of atrial natriuretic factor on central angiotensin II-induced responses in rats (1986) (25)
Homologous regions of collagen α1(I) and α1(II) chains: Apparent clustering of variable and invariant amino acid residues (1974) (25)
Role of vascular angiotensin II released by beta-adrenergic stimulation in rats. (1986) (24)
Candesartan prevents the progression of glomerulosclerosis in genetic hypertensive rats. (1997) (24)
Modification of carboxyl groups in the active site of trypsin. (1970) (24)
Cardiovascular and respiratory effects of endothelin in the ventrolateral medulla of the normotensive rat. (1995) (24)
Angiotensin II in the hippocampus. A histochemical and electrophysiological study (1980) (24)
Role of endogenous atrial natriuretic peptide in congestive heart failure. (1989) (24)
Pregnancy-Induced Changes in Renin Gene Expression in Mice1 (2002) (23)
Nomenclature for atrial peptides. (1987) (23)
Chemical modification of amino groups and guanidino groups of trypsin. Preparation of stable and soluble derivatives. (1975) (23)
Epidermal growth factor-enhanced human angiotensin II type 1 receptor. (1994) (23)
Structure of mouse submaxillary gland renin. Identification of two disulfide-linked polypeptide chains and the complete amino acid sequence of the light chain. (1982) (23)
Renin in the human kidney (1981) (23)
Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system. (1996) (23)
Angiotensin II-mediated vascular smooth muscle cell growth signaling. (2000) (23)
Active and inactive renin in the adrenal. (1989) (23)
Fyn Kinase-directed Activation of SH2 Domain-containing Protein-tyrosine Phosphatase SHP-2 by Gi Protein-coupled Receptors in Madin-Darby Canine Kidney Cells* (1999) (23)
Increased AT1 receptors in adrenal gland of AT2 receptor gene-disrupted mice (2001) (22)
Effect of progesterone on renin secretion in endometrial stromal, chorionic trophoblast, and mesenchymal monolayer cultures. (1991) (22)
Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production. (1999) (22)
Hyperplasia of juxtaglomerular cells and renin localization in kidney of normotensive animals given captopril. Electron microscopic and immunohistochemical studies. (1982) (22)
Angiotensin II receptors: cloning and regulation. (1993) (22)
The renin‐angiotensin system in the rat anterior pituitary: Colocalization of renin and angiotensin II in gonadotrophs (1985) (22)
Isolation and characterization of an endogenous Na+,K(+)-ATPase-specific inhibitor from pig urine. (1993) (21)
Renin Inhibitor and Converting Enzyme Inhibitors Suppress Vascular Angiotensin II (1989) (21)
Identification of individual renocortical cells that secrete renin. (1990) (21)
Significance of Vascular Renin for Local Generation of Angiotensins (1991) (21)
Atrial natriuretic peptide, right atrial pressure, and sodium excretion rate in the rat. (1987) (21)
Direct evidence for local generation and release of angiotensin II in human vascular tissue. (1989) (21)
Atrial natriuretic factor in spontaneously hypertensive rats: concentration changes with the progression of hypertension and elevated formation of cyclic GMP. (1986) (20)
Gonadotropin-Dependent Renin in the Rat Testes (1984) (20)
N-terminal amino acid sequence of the -subunit of human pituitary luteinizing hormone. (1972) (20)
Localization of the mRNA for the Angiotensin II Receptor Subtype 2 (AT2) in Follicular Granulosa Cells of the Rat Ovary by Nonradioactive In Situ Hybridization (1998) (20)
Localization and characterization of a short isoform of the corticotropin-releasing factor receptor type 2alpha (CRF(2)alpha-tr) in the rat brain. (2001) (20)
Phospholipase D in cultured rat vascular smooth muscle cells and its activation by phorbol ester. (1991) (20)
Cloning of genomic DNA for human atrial natriuretic factor. (1984) (20)
Angiotensin II type 1 receptor expression in two cases of juxtaglomerular cell tumor: correlation to negative feedback of renin secretion by angiotensin II. (1999) (20)
Local generation of angiotensin in the kidney and in tissue culture. (1983) (20)
The Renin-Angiotensin System in the Twenty-first Century (2001) (20)
Native form of endothelin receptor in human placental membranes. (1990) (19)
Renin and precursors: purification, characterization, and studies on active site. (1977) (19)
Structure of mouse submaxillary gland renin. (1983) (18)
A search for endogenous Na+,K+-ATPase inhibitor in acutely volume-expanded hog plasma led to lysophosphatidylcholine gamma-stearoyl. (1987) (18)
A new form of renin in normal human plasma: "big renin" is a mixture of inactive prorenin and the new active high molecular weight renin. (1980) (18)
Molecular Insights Into Angiotensin II Receptor Subtypes (1993) (18)
ANP-like immunoreactivity in neuronal perikarya and processes associated with vessels of the pia and cerebral parenchyma in dog (1990) (18)
THE MECHANISM OF THE SPECIFICITY OF TRYPSIN CATALYSIS. II. COMPARISON OF TRYPSIN AND ALPHA-CHYMOTRYPSIN IN THE NONSPECIFIC CATALYSES OF TEH HYDROLYSIS OF ACETYLGLYCINE ETHYL ESTER. (1964) (18)
Purification of a completely inactive renin from hog kidney and identification as renin zymogen. (1982) (18)
HS-142-1, a Novel Non-peptide Antagonist for Atrial Natriuretic Peptide Receptor, Selectively Inhibits Particulate Guanylyl Cyclase and Lowers Cyclic GMP in LLC-PK1 Cells. (1992) (18)
A role for atrial natriuretic peptide in endothelin-induced natriuresis. (1991) (17)
Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells. (1999) (17)
Studies on the Characterization of Pure Submaxillary Gland Renin 1 (1974) (17)
High molecular weight renin in stroke-prone spontaneously hypertensive rats. (1980) (17)
Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation (2014) (17)
Generation of angiotensins in cultured pheochromocytoma cells (1984) (17)
Steroid hormones upregulate rat angiotensin II type 1A receptor gene: Role of glucocorticoid responsive elements in rat angiotensin II type 1A promoter (1995) (17)
Kinetic studies of rat renin and tonin on purified rat angiotensinogen. (1984) (16)
Specificity and mechanism of clostripain catalysis. (1971) (16)
Report of the Joint Nomenclature and Standardization Committee of the International Society of Hypertension, American Heart Association and the World Health Organization (1987) (16)
Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells. (2001) (16)
Mouse kidney renin is synthesised in precursor form in the wheat germ cell-free protein synthesis system (1980) (16)
Identification of essential carboxyl groups in the specific binding site of bovine trypsin by chemical modification. (1971) (16)
Direct proof for local generation and release of angiotensin II in peripheral human vascular tissue. (1991) (16)
Effect of captopril on angiotensin II release from vascular tissues in rats. (1987) (16)
Intracellular formation and release of angiotensins from juxtaglomerular cells. (1990) (15)
Coronary hemodynamics and cardiac beating modulate atrial natriuretic factor release from isolated Langendorff-perfused rat hearts. (1987) (15)
Purification of Renin and Prorenin (1991) (15)
Biochemical studies of rat atrial natriuretic factor. (1985) (15)
PYK2/CAKbeta represents a redox-sensitive tyrosine kinase in vascular smooth muscle cells. (2000) (15)
Angiotensin II-induced structural and functional alterations in spontaneously hypertensive rat kidney. (1996) (15)
Angiotensin receptor signaling in sickle cell anemia has a reno‐protective effect on urine concentrating ability but results in sickle glomerulopathy (2018) (15)
Re-evaluation of the plasma renin-angiotensin system in anephric patients. (1990) (15)
Renal angiotensin converting enzyme promotes renal damage during ureteral obstruction. (1998) (15)
Angiotensin II receptors AT1 and AT2--new mechanisms of signaling and antagonistic effects of AT1 and AT2. (1997) (15)
Release of active and inactive renin from hog renal cortical slices in vitro. (1984) (15)
Tetracycline protects myocardium against ischemic injury. (2005) (15)
Simultaneous identification of PTH derivatives of histidine and arginine by thin-layer chromatography. (1973) (15)
Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells. (1992) (15)
Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide". (2008) (14)
Immunohistochemical localization of atrial natriuretic peptide in the developing and adult mammalian kidney. (1991) (14)
Mitochondrial angiotensin receptors and aging. (2011) (14)
Renal sympathetic nerves modulate glomerular ANP receptors and filtration. (1991) (14)
Renin and angiotensins in cultured mouse adrenocortical tumour cells. (1985) (14)
Immunohistochemical localization of renin in end-stage kidneys. (1988) (13)
Localization of components of the renin-angiotensin system within the kidney and sustained release of angiotensins from isolated and perfused kidney. (1992) (13)
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. (1994) (13)
WORKSHOP : MAJOR PATHOGENETIC FACTORS IN HYPERTENSION (1991) (13)
Localization and secretion of newly synthesized and stored renin: two compartments and secretory mechanisms. (1988) (13)
The subcellular distribution of renin in hog anterior pituitary. (1983) (13)
Involvement of PYK 2 in Angiotensin II Signaling of Vascular Smooth Muscle Cells (1999) (13)
Purification and characterization of specific endogenous ouabainlike substance from bovine adrenal. (1988) (13)
Increased Angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice (2009) (12)
Enhanced phospholipase D activity in vascular smooth muscle cells derived from spontaneously hypertensive rats. (1994) (12)
Intracellular action of renin, angiotensin production and release. (1986) (12)
entaaification of Atrial Natriuretic Factor Receptor of Neuroblastoma N4TG1 Cells: Binding Characteristics and Photoaffinity Labeling (1987) (12)
Identification, Characterization and Evidence for Intraneuronal Function of Renin in the Brain and Neuroblastoma Cells (1982) (12)
The α-chymotrypsin-catalyzed hydrolysis and hydroxylaminolysis of acetyltyrosine p-nitroanilide (1963) (12)
Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis (2008) (12)
Regulation of growth of the adrenal gland in DOC-salt hypertension. Role of angiotensin II receptor subtypes. (1997) (12)
Blockade of the pre- and postjunctional effects of angiotensin in vivo with a non-peptide angiotensin receptor antagonist. (1990) (11)
Direct release of angiotensins I and II from isolated rat kidney perfused with angiotensinogen-free medium. (1987) (11)
Cardiac-specific expression of the human ATI receptor in transgenic rats (1996) (11)
Inhibition of the expression of the gene for the angiotensin AT1 receptor by angiotensin II in the rat adrenal gland. (1998) (11)
Renin precursor and its activation mechanism in hog kidney. (1980) (11)
Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. (1995) (11)
Critical roles of (pro)renin receptor-bound prorenin in diabetes and hypertension: sallies into therapeutic approach. (2008) (11)
Chemical modifications of amino groups of trypsin. (1969) (11)
Immunohistochemical renin study of DES-induced renal tumor in the Syrian hamster. (1988) (11)
Isolation of an endogenous Na-pump specific inhibitor from normal pig urine: characterization and comparison with the inhibitor purified from bovine adrenal glands. (1993) (10)
Effects of Nebivolol on Ischemia-Induced Metabolic Changes in Dog Hearts (2003) (10)
POSTURAL SUPPRESSION OF PLASMA ATRIAL NATRIURETIC POLYPEPTIDE CONCENTRATIONS IN MAN (1987) (10)
Effect of alkylguanidines on the inactivation of trypsin by alkylation and phosphorylation. (1969) (10)
Structure and function of renin (1989) (10)
Juxtaglomerular cells as a source of intrarenal angiotensin II production. (1991) (10)
Mouse submaxillary renin has a protease activity and converts human plasma inactive prorenin to an active form. (1983) (10)
Immunoreactive alpha-human atrial natriuretic polypeptide in human plasma. (1986) (10)
Evidence for existence of angiotensins I and II in mature renin granules from rat kidney cortex. (1985) (10)
Immunoreactive prorenin and its profragment peptide are present in human juxtaglomerular cells (1988) (9)
Direct evidence for the local generation of vascular angiotensin II and its prostaglandin‐mediated release from isolated hind legs in the rat (1988) (9)
Angiotensin converting enzyme inhibitors suppress the vascular renin-angiotensin system of spontaneously hypertensive rats. (1991) (9)
Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy (2013) (9)
Structure and physiological actions of rat atrial natriuretic factor. (1987) (9)
Effect of sodium ion on atrial natriuretic factor release from rat hypothalamic fragments. (1988) (9)
Isolation and culture of juxtaglomerular and renomedullary interstitial cells. (1990) (8)
A kinetic study of the trypsin catalyzed hydrolysis of a specific anilide substrate. (1969) (8)
Changes of AT2 Receptor Levels in the Rat Adrenal Cortex and Medulla Induced by Bilateral Nephrectomy and Its Modulation by Circulating ANG II (2001) (8)
The renin-angiotensin system: an overview of its intracellular function (1988) (8)
A Na pump inhibitor from bovine posterior pituitary: purification, structure determination and its cardiovascular effect in rat. (1992) (8)
Catalytic properties of polymerized alpha-chymotrypsin. (1965) (7)
Role of vascular wall renin: intracellular and extracellular mechanism. (1991) (7)
Tissue Distribution of Atrial Natriuretic Factor and Determination of Its Concentration (1987) (7)
Induced activation of the catalytic site of trypsin. (1963) (7)
Characterization of a synthetic peptide antibody recognizing rat kidney renin and prorenin. (1995) (7)
Acid-activation of rat prorenin following non-proteolytic alteration. (1995) (7)
Renin: structural features of active enzyme and inactive precursor. (1983) (7)
Atrial natriuretic peptide correlates with pulmonary arterial pressure and cardiac output (1987) (7)
Pituitary Renin: Purification and Characterization (1982) (7)
A 45 000 molecular weight human renin precursor is synthesized in a cell-free translation system. (1983) (6)
Subcellular Localization of Angiotensin‐Converting Enzyme in Cultured Neuroblastoma Cells (1986) (6)
Prorenin/renin receptor, signals, and therapeutic efficacy of receptor blocker in end-organ damage (2007) (6)
Platelet-derived growth factor AA homodimer stimulates protein synthesis rather than DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats but not from normotensive rats. (1992) (6)
The storage form of renin in renin granules from rat kidney cortex. (1986) (6)
Cyclosporin A inhibits angiotensin II-induced c-Jun NH(2)-terminal kinase activation but not protein synthesis in vascular smooth muscle cells. (2002) (6)
The antihypertensive mechanism of delapril, a newly developed converting enzyme inhibitor, is related to the suppression of vascular angiotensin II release in the spontaneously hypertensive rat. (1991) (6)
Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007. (2008) (6)
Tissue edema and arterial lesions produced by pure submaxillary gland renin of mouse. (1978) (5)
Na+,K+-ATPase inhibitors in rat urine: origins and physiological significance. (1998) (5)
ESTABLISHMENT OF CHINESE HAMSTER OVARY CELL LINES STABLY EXPRESSING THE CLONED HUMAN TYPE 1 ANGIOTENSIN II RECEPTOR AND CHARACTERIZATION OF THE EXPRESSED RECEPTOR (1992) (5)
Large Scale Purification of an Endogenous Na+/K+-pump Inhibitor from Bovine Adrenal Glands (1994) (5)
Discovery of atrial natriuretic factor in the brain: Its characterization and cardiovascular implication (1989) (5)
EFFECTS OF CHRONIC CONVERTING ENZYME INHIBITION ON THE VASCULAR RENIN‐ANGIOTENSIN SYSTEM (1990) (5)
Copurification of atrial natriuretic factor receptors and guanylyl cyclase from adrenal cortex. (1991) (5)
Effect of delapril hydrochloride on angiotensin II release from isolated rat hind legs. (1990) (5)
3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells INVOLVEMENT OF GERANYLGERANYLATION OF SMALL G PROTEIN Rap1* (2001) (5)
Distinct localization of renin and angiotensins in separate subcellular fractions of the rat adrenal cortex. (1991) (5)
Renin and general aspartyl proteases: differences and similarities in structure and function (1985) (4)
Partial purification of prorenin and activation by kallikreins: a possible new link between renin and kallikrein systems. (1979) (4)
Active site directed inactivators of mouse submaxillary renin. (1975) (4)
Immunohistochemical localization of atrial natriuretic peptide binding sites in juxtaglomerular cells and vascular walls of rat kidney. (1988) (4)
Expression and characterization of recombinant rat angiotensinogen derived from Chinese hamster ovary cells (1992) (4)
G PROTEIN COUPLING AND SECOND MESSENGER GENERATION ARE INDISPENSABLE FOR A METALLOPROTEASE-DEPENDENT HB-EGF SHEDDING THROUGH ANGIOTENSIN II TYPE-1 RECEPTOR (2005) (4)
Is renin secreted by exocytotic mechanism through mature renin granules from juxtaglomerular cells? (1986) (4)
The Angiotensin Type 2 (AT2) Receptor Null Mutant Mice: A Model of the Diverse Spectrum of Congenital Urinary Tract Anomalies in Humans. • 1677 (1997) (4)
Purification of a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. (1988) (4)
Development of an AT2-deficient proximal tubule cell line for transport studies (2007) (4)
New perspectives on secretion of (pro)renin receptor into extracellular space. (2010) (4)
Enhanced local endothelin release contributes to no-reflow phenomenon in the canine model (1991) (4)
Central cardiovascular effects of joining peptide in genetically hypertensive rats. (1993) (4)
Norepinephrine and epinephrine in human erythrocyte plasma membranes. (1988) (3)
Kidney tubular epithelium cells and vascular smooth muscle cells contain different types of atrial natriuretic factor receptors (1988) (3)
Effect of vasodilator prostaglandins on the vascular renin-angiotensin system. (1988) (3)
11 Immunohistochemical Localization of Renin in the (1982) (3)
Association of a polymorphism at the 5'-region of the angiotensin II type 1 receptor with hypertension. (2000) (3)
Conceptual evolution of renin research. (1988) (3)
Atrial natriuretic peptide detected by immunocytochemistry in peripheral organs of Tupaia belangeri (2004) (3)
Biochemistry of renin. (1984) (3)
Endogenous renin inhibitor in neuroblastoma cells (1982) (3)
Multiple forms of immunoreactive renin in human adrenocortical tumour tissue from patients with primary aldosteronism. (1987) (3)
Acid-activated prorenin binds to (pro)renin receptor in vitro. (2012) (3)
Atrial natriuretic factor: purification of active peptides, cloning of cDNA and determination of structures of active peptides and precursors. (1984) (2)
Expression of renin in glomerular nonjuxtaglomerular cells in a child with a hypertensive Bartter's-like syndrome. (1998) (2)
Atrial natriuretic peptide in human neuroblastoma. (1989) (2)
A new form of inactive renin in rat brain. A latent renin. (1984) (2)
Molecular Structure and Transcriptional Regulation of the Gene for the Platelet-derived Growth Factor a Receptor in Cultured Vascular Smooth Muscle Cells (2013) (2)
MOLECULAR GENETICS OF THE SA GENE (1994) (2)
Cultured juxtaglomerular cells cause hypertension by secreting angiotensin. (1982) (2)
CONTROL OF CIRCULATORY VOLUME AND SODIUM EXCRETION DURING CARDIAC SURGERY BY ATRIAL NATRIUETIC FACTOR (1987) (2)
Effect of alkylguanidines and alkylamines on trypsin catalysis. (1968) (2)
Atrial natriuretic factor stimulates phosphorylation of a 52-kDa calmodulin-binding protein in vascular smooth muscle cells. (1993) (1)
Functional characterization of the decoy peptide, [R10P]IFLKRMPSI[19P]. (2010) (1)
Abstract 3480: Shedding of (Pro)renin Receptor is Essential for Intracellular Signaling (2008) (1)
Angiotensin II-mediated pressor effect of rat joining peptide. (1994) (1)
Prorenin binding to (pro)renin receptor and its inhibition by the decoy peptide (RIFLKRMPSI) in vitro (2008) (1)
Atrial natriuretic factor is biologically active also in the absence of vasopressin: studies on Brattleboro-strain diabetes insipidus rats. (1987) (1)
Accelerated hypertension in a 54-year-old woman. (1981) (1)
Beta-adrenergic modulation of the release of atrial natriuretic factor from rat cardiac atria in vitro (1986) (1)
Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
THE ALKYLATION OF THE ACTIVE SITE OF TRYPSIN WITH IODOACETAMIDE IN THE PRESENCE OF ALKYLGUANIDINES. (1965) (1)
Antiscrum to Atrial Natriuretic Factor Lowers Urinary Output, Urinary Sodium Excretion, and Plasma Renin Activity (1986) (1)
PDGF induces a ROS and Src kinase‐dependent PKC‐delta Tyr‐311 phosphorylation promoting vascular smooth muscle cell growth and proliferation (2006) (1)
A novel endogenous sodium-pump inhibitor in pig urine: purification and comparison with the inhibitor purified from bovine adrenal glands. (1993) (1)
Angiotensin II type 2 receptor blockade increases bone mass. (2009) (1)
AT-2 receptor participates in blood pressure regulation in a diet induced sodium-dependent high blood pressure in rats (1997) (1)
Recent Development in the Biochemistry of Renin (1979) (1)
Homologous regions of collagen alpha1(I) and alpha1(II) chains: apparent clustering of variable and invariant amino acid residues. (1974) (1)
Purification of Prorenin (1984) (1)
High Molecular Weight Renins in Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat (1977) (1)
Reaction of diisopropylphosphorofluoridate with N-acetyl-L-tyrosinamide. (1970) (1)
Diversity of angiotensin receptors: Cloning and signaling mechanism (1994) (1)
NEUROBIOLOGY OF HYPONATREMIA IN SCHIZOPHRENIA (1992) (1)
Preparation of a specific high-titer antibody against rat kidney renin. (1985) (1)
Identification of Na+,K+-ATPase inhibitors of volume-expanded hog plasma. (1987) (1)
Mouse submandibular renin (2004) (1)
Angiotensin II receptors: cloning and expression. (1994) (1)
Identification of lysophosphatidylcholine,. gamma. -stearoyl (LPCD) as an endogenous Na/sup +/, K/sup +/-ATPase inhibitor in volume-expanded hog plasma (1986) (1)
A New Role for Mammalian Angiotensin; Adapting the Kidney to Extrauterine Life • 1826 (1998) (1)
Isolation and characterization of renin and high molecular weight forms of renin from various species. (1979) (1)
Interaction between the vascular renin‐angiotensin system and prostaglandins (1988) (1)
Identification and physiological significance of Na+/K+-pump inhibitors in rats (1994) (1)
Angiotensin II receptors: cloning, structure, function and regulation. (1993) (1)
The renin and angiotensin system part 1 (2002) (0)
QUANTITATIVE ANALYSIS OF (PRO)RENIN RECEPTOR IN THE MEDIUM OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS, HUVEC: 6D.05 (2011) (0)
THE RENIN-ANGIOTENSIN SYSTEM : RECEPTOR FUNCTION AND CARDIOVASCULAR REGULATION (1997) (0)
Angiotensin II type 2 receptor – PLZF signaling requires tyrosine phosphorylation of PLZF by JAK2 (2007) (0)
Mechanism of Action of Atrial Natriuretic Factor in the Adrenal Gland (1989) (0)
Pyk2 Is a Redox-Sensitive Tyrosine Kinase in Vascular Smooth Muscle Cells (2000) (0)
ROLES AND SIGNALING MECHANISMS OF THE TYPE 2 ANGIOTENSIN II RECEPTOR, AT_2, IN CARDIAC HYPERTROPHY (2002) (0)
Renin and precursors : purification, characterization and activation mechanism (author's transl). (1977) (0)
Subject Index Vol. 35, 1982 (1982) (0)
Rat atrial natriuretic factor: chemical and molecular biological studies and application to physiological research (1986) (0)
Does Handle Region Peptide Provide Benefits in Chronic Kidney Disease (2009) (0)
Regulation of Steroidogenic Responsiveness and Cyclic Nucleotide Levels by Atrial Natriuretic Factor in Isolated Mouse Leydig Cells a (1987) (0)
THE ANGIOTENSIN RECEPTORS IN CARDIOVASCULAR SYSTEM AND NEWER ASPECTS OF SIGNALING (1998) (0)
Primary Structure of Mouse Submaxillary Gland Renin (1984) (0)
[Renin (author's transl)]. (1980) (0)
Binding, Ineternalization, and Degradation of Atrial Natriuretic Factor (ANF) in Cultured Leydig Tumor Cells (1986) (0)
Pathophysiological significance of Na+-pump inhibitors in rats (1994) (0)
, Tadashi Inagami and Lisa Cassis dominant polycystic kidney disease The intrarenal renin-angiotensin system in autosomal (2004) (0)
Workshop Major Pathogenetic Factors in Hypertension: Participants (1991) (0)
Atrial natriuretic factor: biochemical and pathophysiological studies (1986) (0)
Growth stimulating and inhibitory signals of angiotensin II type 2 receptor are mediated by PLZF and SHP‐1 (2006) (0)
Direct evidence of interconversion of high and low r.olecular-weight renins using 125I-iabeled rat renal renin (1983) (0)
Coordinated regulation of epidermal Growth Factor Signaling by the protein tyrosine phosphatases SHP‐1 and SHP‐2 (2006) (0)
Intracellular Actions of Renin (1984) (0)
Immunohistochemical renin study of des-induced syrian hamster renal tumor (1987) (0)
Renin in cultured cells of neural crest origin (abstract). (1984) (0)
Introduction – Advances in Renin Research (1988) (0)
Amino acid sequence of mouse submaxillary gland renin (homology (0)
Purification and Properties of Bovine Pituitary Renin (1982) (0)
The Molecular Biology of the Renin-Angiotensin System (1995) (0)
BIOCHEMICAL PROPERTIES OF NON-PROTEOLYTICALLY ACTIVATED PRORENIN: ELUCIDATION OF ITS BINDING KINETICS AND MOLECULAR ACTIVITIES: PP.24.463 (2010) (0)
Angiotensin II stimulates a novel angiotensin II type 1 receptor-associated protein, GLP gene expression in rat kidney proximal tubular cells (2006) (0)
Atrial Natriuretic Factors and Fragments (1993) (0)
Major pathogenetic factors in hypertension participants (1991) (0)
Abstract P102: Apelin Regulates the Function of Angiotensin II Type 1 Receptor Through APJ (2011) (0)
Correction: Commercially Available Angiotensin II AT2 Receptor Antibodies Are Nonspecific (2014) (0)
Control Mechanisms of Renin Synthesis and Release : A 21 st Century Perspective NO and cGMP mediate angiotensin AT 2 receptor-induced renal renin inhibition in young rats (2007) (0)
Identification of renin in cloned neuroblastoma cells and its properties. (1983) (0)
Direct Radioimmunoassay of Renin and Its Application : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION (1981) (0)
NONSPECIFIC CATALYSES BY TRYPSIN AND α-CHYMOTRYPSIN (1963) (0)
Recent progress in Ang II receptors (1995) (0)
Requirement of Ca 2 (cid:1) and PKC (cid:2) for Janus Kinase 2 Activation by Angiotensin II: Involvement of PYK2 (2002) (0)
Abstract 351: Distinct Requirement of PKC{delta} Tyr311 Phosphorylation and Kinase Activity for Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II (2006) (0)
Photoaffmity Labeling of Atrial Natriuretic Factor (ANF) Receptors in Cultured Murine Leydig Tumor Cells and Neuroblastoma Cells (1986) (0)
Reply to Graafsma (1992) (0)
Cloning, expression and regulation of angiotensin II receptors. (1994) (0)
Molecular characterization of inactive renin: complete purification of prorenin in hog kidney and isolation of inactive renin from neuroblastoma cells: evidence for 2 different types of inactive renin. (1982) (0)
The renin and angiotensin system part 1:Biochemical aspects of renin (2002) (0)
Immunohistochemical Localization of Renin in Rat Adrenal. (1986) (0)
ANGIOTENSIN II RECEPTOR CLONING AND SIGNALING (1996) (0)
Exaggerated response to electrical nerve stimulation of angiotensin II release in isolated perfused hind legs of spontaneously hypertensive rats. (1991) (0)
Mono clonal antibodies against renin (1981) (0)
Renin and angiotensin II receptor expression in the brains of DES‐treated Syrian hamsters (1997) (0)
Interferon-γ upregulates rat angiotensin ii type 1a receptor in cultured vascuur smooth muscle cells (1996) (0)
The alpha-chymotrypsin-catalyzed hydrolysis and hydroxylaminolysis of acetyltyrosine p-nitroanilide. (1964) (0)
GeneTargeting inMiceReveals a Requirement forAngiotensin inthe Development andMaintenance ofKidney Morphology and GrowthFactor Regulation (1995) (0)
Reactive oxygen species transactivate EGF and PDGF receptor through distinct signal transduction (2002) (0)
Physiologic and pathophysiologic aspects of plasma immunoreactive Ouabain in man (1994) (0)
Concanavalin A-mediated inhibition of angiotensin II-stimulated tyrosine phosphatase SHP-2 is associated with suppression of MAP kinase in vascular smooth muscle cells (1998) (0)
Neuroendocrine determinants of disturbed water regulation in schizophrenia (1991) (0)
PROTECTIVE ROLE OF THE ANGIOTENSIN II TYPE2 RECEPTOR SIGNALING PATHWAY IN A MOUSE MODEL OF PANCREATITIS (2007) (0)
High molecular weight renins in spontaneously hypertensive rat and stroke-prone spontaneously hypertensive rat [proceedings]. (1977) (0)
A Centennial of Renin Discovery (1998) (0)
Recent development in the biochemistry of renin [proceedings]. (1979) (0)
Na+,K+-ATPase Inhibitors in Rat Urine: Structres and Physiological Significance (1997) (0)
Physiological Function and Localization of a Short Isoform of the Corticotropin-Releasing Factor Receptor Subtype (CRF2α-tr) in the Rat Brain (2000) (0)
Renin immunoreactivity in Leydig cells (1982) (0)
Saturday May 31, Ballroom C, 11:00 am Theme I: Angiotensin Receptors: AT2-New mechanisms (1997) (0)
圧負荷心肥大モデルラットにおいて1B型アンジオテンシンII受容体が媒介するトランスフォーミング増殖因子ベータ1(TGF‐ベータ1)の増加が引き起こす心筋線維化 (1996) (0)
Receptor Binding Proteins: the Promise of theAngiotensin type 2 (AT 2 ) Receptor (2012) (0)
Activity and molecular weight of renin of plasma and kidney in SHRSP [proceedings]. (1979) (0)
Significant roles of prorenin and (pro)renin receptor in development and progression of diabetic nephropathy (2008) (0)
Pathophysiological role of cardiac glycosides in the adrenal gland (1994) (0)
STRUCTURAL ELEMENTS FOR SPECIFIC BINDING OF ANGIOTENSIN II TO ITS TYPE I RECEPTOR BY SITE-DIRECTED MUTAGENESIS (1993) (0)
Normoaldosteronism in Severe Autonomic Failure (1993) (0)
Abstract 7: Angiotensin II Type 2 Receptor Deficiency Increases Renal ACE/ACE2 Ratio-Ang II-AT1R Expression In Male but not in Female Mice (2012) (0)
Ultrastructura1 Immunocytochemica1 Localization of Renin and Angiotensin II in the Juxtaglomerular Cells of the Ischemic Kidney in Experimental Renal Hypertension (2007) (0)
Glomerular and Renal Vascular Responses to Endothelin in the Rat Kidney Elucidation of Signal Transduction Pathways (2013) (0)

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