T. Kendall Harden

T. Kendall Harden's AcademicInfluence.com Rankings

T. Kendall Harden

Medical

#1813

World Rank

#2189

Historical Rank

Pharmacology

#171

World Rank

#210

Historical Rank

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Medical

T. Kendall Harden's Degrees

PhD Pharmacology University of California, San Diego
Bachelors Pharmacology University of California, San Diego

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T. Kendall Harden's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Nomenclature and classification of purinoceptors. (1994) (1631)
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance (2009) (1335)
Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. (2003) (576)
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. (1978) (443)
Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. (1983) (432)
P2-purinergic receptors: subtype-associated signaling responses and structure. (1995) (362)
Towards a revised nomenclature for P1 and P2 receptors. (1997) (361)
Constitutive Release of ATP and Evidence for Major Contribution of Ecto-nucleotide Pyrophosphatase and Nucleoside Diphosphokinase to Extracellular Nucleotide Concentrations* (2000) (334)
Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation* (1997) (319)
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. (1980) (288)
Identification of competitive antagonists of the P2Y1 receptor. (1996) (257)
The experimental power of FR900359 to study Gq-regulated biological processes (2015) (251)
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1‐purinoceptor (1996) (237)
Pharmacological selectivity of the cloned human P2U‐purinoceptor: potent activation by diadenosine tetraphosphate (1995) (236)
beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex. (1976) (228)
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. (1985) (218)
Competitive and selective antagonism of P2Y1 receptors by N6‐methyl 2′‐deoxyadenosine 3′,5′‐bisphosphate (1998) (212)
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. (1994) (189)
Kinetic Scaffolding Mediated by a Phospholipase C–β and Gq Signaling Complex (2010) (188)
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. (1983) (185)
Beta gamma-subunit activation of G-protein-regulated phospholipase C. (1992) (176)
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. (1989) (173)
PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. (2003) (166)
Agonist action of adenosine triphosphates at the human P2Y1 receptor. (1998) (162)
Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. (1991) (162)
Quantitation of extracellular UTP using a sensitive enzymatic assay (1999) (156)
Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. (1988) (149)
General and versatile autoinhibition of PLC isozymes. (2008) (149)
RGS6, RGS7, RGS9, and RGS11 Stimulate GTPase Activity of Gi Family G-proteins with Differential Selectivity and Maximal Activity* (2003) (148)
Release of cellular UDP-glucose as a potential extracellular signaling molecule. (2003) (146)
Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. (1998) (145)
The phospholipase C isozymes and their regulation. (2012) (144)
Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. (1987) (142)
Regulation of phospholipase C isozymes by ras superfamily GTPases. (2006) (142)
Differential effects of P2‐purinoceptor antagonists on phospholipase C‐ and adenylyl cyclase‐coupled P2Y‐purinoceptors (1994) (140)
DLC‐1 suppresses non‐small cell lung cancer growth and invasion by RhoGAP‐dependent and independent mechanisms (2008) (140)
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. (1997) (139)
The Role of Amino Acids in Extracellular Loops of the Human P2Y1 Receptor in Surface Expression and Activation Processes* (1999) (132)
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors (1997) (131)
Ontogeny of β-adrenergic receptors in rat cerebral cortex (1977) (130)
Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor. (2004) (129)
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. (1980) (127)
beta-adrenergic receptors in rat liver: effects of adrenalectomy. (1976) (127)
Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. (1998) (127)
Overview of the Alliance for Cellular Signaling (2002) (125)
Identification of an Ecto-nucleoside Diphosphokinase and Its Contribution to Interconversion of P2 Receptor Agonists* (1997) (124)
Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s). (1982) (124)
Crystal structure of Rac1 bound to its effector phospholipase C-β2 (2006) (123)
UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. (1997) (122)
Molecular pharmacology, physiology, and structure of the P2Y receptors. (2011) (119)
Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity. (1997) (119)
Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. (1993) (118)
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. (2003) (115)
ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. (2000) (115)
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. (1982) (112)
G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness (2012) (111)
Development of selective agonists and antagonists of P2Y receptors (2008) (109)
Crystal structure of the multifunctional Gβ5–RGS9 complex (2008) (109)
Induction of Novel Agonist Selectivity for the ADP-Activated P2Y1 Receptor Versus the ADP-Activated P2Y12 and P2Y13 Receptors by Conformational Constraint of an ADP Analog (2004) (108)
Identification of two benzodiazepine binding sites on cells cultured from rat cerebral cortex. (1981) (108)
Supersensitivity in rat cerebral cortex: pre- and postsynaptic effects of 6-hydroxydopamine at noradrenergic synapses. (1977) (107)
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. (1979) (104)
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. (2000) (104)
Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits. (1994) (104)
Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells. (1978) (104)
The Pleckstrin Homology Domain of Phospholipase C-β2 as an Effector Site for Rac* (2003) (103)
Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits* (2001) (100)
Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells (1984) (99)
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. (1993) (97)
Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes*♦ (2010) (96)
Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein. (1991) (92)
Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor. (1989) (92)
Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. (1994) (92)
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. (2002) (92)
Direct Activation of Phospholipase C-ϵ by Rho* (2003) (91)
Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. (2004) (91)
Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. (1984) (91)
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. (1996) (89)
A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq (2002) (88)
Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes (1994) (88)
In vitro study of beta-adrenergic receptors. (1977) (87)
Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms. (1984) (86)
Effects of 6-hydroxydopamine on the development of the beta adrenergic receptor/adenylate cyclase system in rat cerebral cortex. (1977) (85)
A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. (2011) (83)
A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils (2013) (83)
Quantification of Gi-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y14 Receptor (2009) (82)
Purification and functional reconstitution of the human P2Y12 receptor. (2003) (82)
Protein Kinase C Phosphorylates RGS2 and Modulates Its Capacity for Negative Regulation of Gα11 Signaling* (2001) (82)
2‐Chloro N6‐methyl‐(N)‐methanocarba‐2′‐deoxyadenosine‐3′,5′‐bisphosphate is a selective high affinity P2Y1 receptor antagonist (2002) (81)
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. (1987) (81)
Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. (1981) (81)
Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart. (1976) (81)
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. (1985) (80)
Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. (1985) (80)
Signalling and pharmacological properties of the P2Y14 receptor (2010) (80)
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. (2002) (78)
Functional expression of a cDNA encoding a human ecto‐ATPase (1999) (78)
Role of Isoprenoid Lipids on the Heterotrimeric G Protein γ Subunit in Determining Effector Activation* (1999) (76)
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (2005) (76)
H1-histamine receptors on human astrocytoma cells. (1986) (76)
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. (2001) (76)
Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase (2001) (75)
UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation (2015) (73)
Agonist-induced internalization of the P2Y2 receptor. (1998) (73)
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. (2002) (71)
Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. (2001) (71)
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. (1988) (71)
Adenosine receptors on human airway epithelia and their relationship to chloride secretion (1992) (70)
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference. (2005) (70)
Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization. (1984) (68)
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. (2008) (68)
Differential Regulation of the Uridine Nucleotide-activated P2Y4 and P2Y6 Receptors (2001) (67)
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. (1986) (66)
The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery (2000) (66)
Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain. (1982) (66)
Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform* (2009) (64)
Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation. (1985) (64)
A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. (1998) (63)
Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. (2001) (63)
The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. (1997) (61)
Molecular cloning and characterization of PLC‐η2 (2005) (61)
Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C (1997) (61)
RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism* (2004) (61)
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. (2006) (59)
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. (1984) (58)
Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. (1989) (58)
Gα12/13- and Rho-Dependent Activation of Phospholipase C-ϵ by Lysophosphatidic Acid and Thrombin Receptors (2006) (58)
Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. (2002) (58)
Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U‐purinoceptors (1996) (57)
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. (1985) (57)
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. (1987) (57)
Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3',5'-monophosphate (cGMP). (1978) (55)
Gi-Dependent Cell Signaling Responses of the Human P2Y14 Receptor in Model Cell Systems (2009) (54)
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. (1999) (54)
Hormone and growth factor receptor-mediated regulation of phospholipase C activity. (1989) (52)
Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate. (2000) (51)
Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium. (1994) (50)
Platelet‐derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells (1989) (50)
Agonist Versus Antagonist Action of ATP at the P2Y4 Receptor Is Determined by the Second Extracellular Loop* (2004) (49)
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. (2012) (49)
Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps. (1995) (49)
Identification of potent P2Y‐purinoceptor agonists that are derivatives of adenosine 5′‐monophosphate (1996) (49)
Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. (2007) (49)
UDP Is a Competitive Antagonist at the Human P2Y14 Receptor (2008) (48)
Molecular cloning and expression of an avian G protein-coupled P2Y receptor. (1997) (47)
Regulation of P2Y1 Receptor-Mediated Signaling by the Ectonucleoside Triphosphate Diphosphohydrolase Isozymes NTPDase1 and NTPDase2 (2005) (47)
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. (1989) (47)
N-Ethylmaleimide-induced alteration in the interaction of agonists with muscarinic cholinergic receptors of rat brain. (1983) (46)
Polarized expression of human P2Y receptors in epithelial cells from kidney, lung, and colon. (2005) (46)
Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide. (2010) (46)
2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. (2002) (46)
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. (2007) (45)
Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor. (1998) (45)
Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. (1986) (45)
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor. (2011) (45)
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go. (1987) (45)
Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17 (2013) (45)
Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. (2011) (45)
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. (2001) (44)
Acireductone Dioxygenase 1 (ARD1) Is an Effector of the Heterotrimeric G Protein β Subunit in Arabidopsis* (2011) (44)
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. (2010) (44)
High-affinity binding of agonists to beta-adrenergic receptors on intact cells. (1983) (44)
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. (2006) (42)
A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation. (2014) (41)
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties. (1990) (41)
UDP-glucose promotes neutrophil recruitment in the lung (2016) (41)
Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors (1998) (40)
Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart. (1984) (40)
[32P]2‐iodo‐N6‐methyl‐(N)‐methanocarba‐2′‐deoxyadenosine‐3′,5′‐bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors (2006) (40)
A comparison of calcium-activated potassium channel currents in cell- attached and excised patches (1987) (40)
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni. (1985) (40)
A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts. (1990) (40)
Dexamethasone increases β-adrenoceptor density in human astrocytoma cells (1980) (40)
Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases* (2008) (39)
Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors. (1983) (37)
Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7. (1997) (37)
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. (1987) (37)
Synthesis and structure‐activity relationships of pyridoxal‐6‐arylazo‐5′‐phosphate and phosphonate derivatives as P2 receptor antagonists (1998) (36)
Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C. (1989) (36)
Activation of human phospholipase C-eta2 by Gbetagamma. (2008) (35)
[32P]3'-O-(4-benzoyl)benzoyl ATP as a photoaffinity label for a phospholipase C-coupled P2Y-purinergic receptor. (1990) (35)
Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor. (2008) (35)
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. (2010) (34)
Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation. (1997) (34)
Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation. (1983) (34)
Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-beta. (1999) (34)
Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes (2014) (33)
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists (2016) (33)
Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis. (1990) (33)
Dominant-negative Inhibition of Pheromone Receptor Signaling by a Single Point Mutation in the G Protein α Subunit* (2004) (33)
A Guanine Nucleotide-independent Inwardly Rectifying Cation Permeability Is Associated with P2Y1 Receptor Expression in Xenopus Oocytes* (1996) (33)
Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. (2013) (32)
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. (1979) (32)
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. (1988) (32)
Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. (2004) (32)
Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13 * (2001) (32)
Potent agonist action of 2‐thioether derivatives of adenine nucleotides at adenylyl cyclase‐linked P2y‐purinoceptors (1995) (32)
Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. (2009) (31)
P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. (2007) (30)
Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500). (2010) (30)
Noradrenergic hyperinnervation reduces the density of β-adrenergic receptors in rat cerebellum (1979) (30)
Irreversible activation of phospholipase C-coupled P2Y-purinergic receptors by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. (1989) (30)
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors. (2004) (30)
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. (2002) (30)
Molecular cloning and characterization of a novel beta-adrenergic receptor. (1994) (29)
Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen* (2013) (29)
Membrane-induced Allosteric Control of Phospholipase C-β Isozymes* (2014) (29)
Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. (1999) (28)
Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein. (2000) (28)
Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands (2009) (28)
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits. (2001) (27)
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. (2000) (27)
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. (1990) (27)
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide. (1984) (27)
Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness (1978) (27)
Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. (1987) (26)
(N)‐methanocarba‐2MeSADP (MRS2365) is a subtype‐specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets (2006) (26)
Requirement of Cys399 for Processing of the Human Ecto-ATPase (NTPDase2) and Its Implications for Determination of the Activities of Splice Variants of the Enzyme* (2003) (26)
Release of ATP and UTP from astrocytoma cells. (1999) (26)
Identification of Gα11 as the phospholipase C-activating G-protein of turkey erythrocytes (1993) (26)
Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system. (2006) (25)
Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. (1996) (24)
Acute and Chronic Modulation of the Responsiveness of Receptor-Associated Adenylate Cyclases (1982) (24)
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. (2006) (23)
Molecular cloning and characterization of PLC-eta2. (2005) (23)
Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties (1996) (23)
GPR80/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor (2004) (23)
Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition. (2009) (23)
Concentration of enzyme-dependent activation of PLC-β1 and PLC-β2 by Gα11 and βγ-subunits (1995) (23)
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates. (2000) (22)
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. (1986) (22)
Purification and G Protein Subunit Regulation of a Phospholipase C-β from Xenopus laevis Oocytes* (1996) (21)
Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. (2010) (21)
Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations (2019) (21)
Differential expression of components of the adenylate cyclase system during growth of astrocytoma cells in culture. (1979) (21)
G-protein-mediated regulation of phospholipase C Involvement of βγ subunits. (1994) (21)
Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal (2010) (20)
Biochemical Properties of a P2Y‐Purinergic Receptor (1990) (19)
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines. (1987) (19)
4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6 Receptors (2014) (18)
Newly synthesized norepinephrine accumulation in the readily releasable pool of a purified adrenergic vesicle fraction. (1975) (18)
Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor. (2015) (18)
Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. (1996) (18)
Effects of tunicamycin on the expression of beta-adrenergic receptors in human astrocytoma cells during growth and recovery from agonist-induced down-regulation. (1985) (18)
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment. (1986) (18)
Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors. (1985) (18)
Receptor-induced heterologous desensitization of receptor-regulated phospholipase C. (1995) (17)
Potent and Selective Peptide-based Inhibition of the G Protein Gαq* (2016) (17)
Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. (2000) (17)
G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). (2001) (16)
Guanine nucleotides modulate the affinity of antagonists at beta-adrenergic receptors. (1981) (16)
A sensitive equilibrium binding assay for soluble beta-adrenergic receptors. (1981) (15)
Protein Kinase C-Promoted Inhibition of Gα11-Stimulated Phospholipase C-β Activity (1999) (15)
Nucleotides released by apoptotic cells act as a find-me signal for phagocytic clearance (2010) (15)
Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells. (1984) (15)
Receptor nomenclature (15)
Purification of G-protein-regulated phospholipase C from turkey erythrocytes. (1994) (14)
C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. (2003) (14)
Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins. (1978) (14)
By-Subunit Activation of G-protein-regulated Phospholipase C* (2001) (14)
G protein-dependent regulation of phospholipase C by cell surface receptors. (1990) (13)
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells. (1983) (13)
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations (2019) (13)
Regulation of phospholipase C. (1990) (13)
Receptor- and G-protein-regulated 150-kDa avian phospholipase C: inhibition of enzyme activity by isoenzyme-specific antisera and nonidentity with mammalian phospholipase C isoenzymes established by immunoreactivity and peptide sequence. (1991) (13)
Acyclic Analogues of Deoxyadenosine 3′,5′‐Bisphosphates as P2Y1 Receptor Antagonists. (2000) (13)
The G Protein-Coupled P2Y Receptors (1998) (12)
A fusion protein of the human P2Y(1) receptor and NTPDase1 exhibits functional activities of the native receptor and ectoenzyme and reduced signaling responses to endogenously released nucleotides. (2002) (12)
DRUG ANALYSIS BASED ON SIGNALING RESPONSES TO G-PROTEIN-COUPLED RECEPTORS (2001) (10)
Solubilization of a Guanine Nucleotide‐Sensitive Form of the P2Y‐Purinergic Receptor from Turkey Erythrocyte Membranes (1990) (10)
Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors (2001) (10)
Ontogeny of beta-adrenergic receptors in rat cerebral cortex. (1977) (10)
A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes (2017) (10)
Drug-induced modification of the responsiveness of adenylate cyclase to hormones. (1978) (10)
Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays. (1996) (10)
Regulation of beta-adrenergic receptors in the cerebral cortex. (1978) (9)
Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. (2013) (9)
Muscarinic Cholinergic Receptor-Mediated Regulation of Cyclic AMP Metabolism (1989) (9)
Adrenergic storage vesicles in rat heart: quantitation of membrane-bound and membrane-enclosed dopamine beta-hydroxylase. (1978) (9)
Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. (2012) (9)
Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes. (1996) (8)
The stable pyrimidines UDPbS and UTPgS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery (8)
RhoA Activates Purified Phospholipase C- (cid:1) by a Guanine Nucleotide-dependent Mechanism* (2004) (8)
Development of an assay for phospholipase C using column-reconstituted, extruded phospholipid vesicles. (1999) (8)
Dexamethasone increases beta-adrenoceptor density in human astrocytoma cells. (1980) (8)
Regulation of cAMP metabolism, protein kinase activation, and specific enzyme synthesis in cultured hepatoma cells. (1978) (7)
Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness (2012) (7)
Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins (2004) (7)
Molecular Cloning and Expression of an Avian G Protein-Coupled P 2 Y Receptor (1997) (7)
Protein kinase C-promoted inhibition of Galpha(11)-stimulated phospholipase C-beta activity. (1999) (7)
Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles. (2006) (7)
Purification of an AIFT and G-protein @r-Subunit-regulated Phospholipase C-activating Protein* (2001) (7)
Evidence that the p 2 y 3 Receptor Is the Avian Homologue of the Mammalian P 2 Y 6 Receptor (1998) (6)
Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. (2001) (6)
Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. (1988) (6)
Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes. (1993) (6)
Purification and in vitro functional analysis of R7 subfamily RGS proteins in complex with Gbeta5. (2004) (6)
Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats (1984) (6)
Novel ATP Agonists Reveal Receptor Heterogeneity Within P2X and P2Y Subtypes (1995) (6)
Serum dopamine beta-hydroxylase activity following subarachnoid hemorrhage in man. (1975) (5)
Purification of phospholipase C-activating G protein, G11, from turkey erythrocytes. (1994) (5)
Cyclic AMP and beta-adrenergic receptors during the development of physical dependence on ethanol in the rat. (1980) (5)
Ser352 and Ser354 in the carboxyl terminus of the human P2Y1 receptor are required for agonist‐promoted phosphorylation and internalization in MDCK cells (2011) (5)
Heterogeneous responses of cell Ca2+ in human airway epithelium. (1999) (5)
Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand (2014) (5)
Adaptive changes in the responsiveness of adenylate cyclase to catecholamines. (1979) (5)
Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice. (1986) (5)
[17] Expression, purification, and functional reconstitution of recombinant phospholipase C-β isozymes (1996) (5)
CHAPTER 225 – The RGS Protein Superfamily (2003) (4)
Purification and Functional Reconstitution of the Human P 2 Y 12 Receptor (2003) (4)
β-Adrenergic receptor density in brains of ethanoldependent rats (1979) (4)
Regulation of beta-adrenergic receptors during exposure of astrocytoma cells to catecholamines. (1984) (4)
G-protein-regulated phospholipase C. Identification of component proteins. (1992) (4)
Structures of G [alpha [superscript i1]] Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange (2010) (3)
Epidermal Growth Factor Stimulates the Rapid Accumulation of Inositol ( 1 , 4 , 5 )-Trisphosphate and a Rise in Cytosolic Calcium Mobilized from Intracellular Stores in A 431 Cells * (2001) (3)
Avian G-protein-regulated phospholipase C. (1991) (3)
Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. (1994) (3)
Enigmatic GPCR Finds a Stimulating Drug (2013) (3)
Kinetic Analysis of Phospholipase C Isoforms Using Phospholipid-Detergent Mixed Micelles (1995) (3)
Depression of Atrial Contractility by Peptides Isolated from Normal and Shock Plasma 1 (1973) (3)
The First 50 Years of Molecular Pharmacology (2015) (3)
CATECHOLAMINE-INDUCED DESENSITIZATION OF THE β-RECEPTOR-LINKED ADENYLATE CYCLASE (1979) (2)
Author response: Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations (2019) (2)
C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands. (2004) (2)
Structure-Activity Relationships of Pyridoxal Phosphate Derivatives as Potent and Selective Antagonists of P 2 X 1 Receptors (2)
Design, Synthesis and Pharmacological Characterization of a Fluorescent Agonist of the P2Y 14 Receptor (2015) (2)
Regulation of Phospholipase C-β Isoenzymes (1996) (2)
Muscarinic cholinergic receptor-mediated attenuation of adenylate cyclase activity in rat heart membranes. (1985) (1)
CHARACTERIZATION OF THE EFFICACY OF β-ADRENERGIC RECEPTOR AGONISTS IN TERMS OF THE STEADY STATE MODEL FOR THE ACTIVATION OF ADENYLATE CYCLASE (1979) (1)
Erratum: Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein α subunit (Journal of Biological Chemistry (2004) 279 (35287-35297)) (2005) (1)
f-Adrenergic receptors in rat liver : Effects of adrenalectomy ( iodohydroxybenzylpindolol binding / supersensitivity of adenylate cyclase / hormone receptors in liver ) (1)
Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro. (2023) (1)
Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits. (1995) (1)
Molecular Recognition in the P2Y14 Nucleotide Receptor: Probing the Structurally Permissive Terminal Sugar Moiety of Uridine-5′- diphosphoglucose (2009) (1)
Regulation of PLCbeta isoforms by Rac. (2006) (1)
β Adrenergic receptors of intact and broken human astrocytoma cells (1976) (1)
Regulation of PLCβ Isoforms by Rac (2006) (1)
Faculty Opinions recommendation of G protein-coupled receptors in Anopheles gambiae. (2002) (0)
REGULATION OF β-ADRENERGIC RECEPTORS IN HUMAN ASTROCYTOMA CELLS (1979) (0)
Binding on ice of 125I-pindolol to control and isoproterenol-treated cells (1985) (0)
Evidence for catecholamine-induced internalization of the β-adrenergic receptor (1980) (0)
Contents of Volume 1 (2005) (2005) (0)
beta-adrenergic receptor density in brains of ethanol-dependent rats. (1979) (0)
THE USE OF RADIOLABELED LIGANDS TO STUDY β-ADRENERGIC RECEPTORS1 (1976) (0)
G-Proteins and Signal Transduction Annual Symposium (43rd), Held in Woods Hole, Massachusetts on September 6-9, 1989 (1989) (0)
Irreversible Activation and Photoaffinity Labeling of a P2Y‐Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes (1990) (0)
ATP-mimetics derived from 2 '(3 ')-C-methyladenosine as human P2Y2 agonists (2008) (0)
G (cid:1) Association and Effector Interaction Selectivities of the Divergent G (cid:2) Subunit G (cid:2) 13 * (2001) (0)
Faculty Opinions recommendation of The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. (2002) (0)
UDP-glucose promotes neutrophil recruitment in the lung (2016) (0)
G proteins and signal transduction : Society of General Physiologists, 43rd Annual Symposium : Marine Biological Laboratory, Woods Hole, Massachusetts, 6-9 September, 1989 (1990) (0)
P2Y14 receptor‐mediated Rho activation in human neutrophils (2011) (0)
Crystal Structure of Phospholipase C Beta 2 (2008) (0)
1133 – THE USE 0F DIOLABELLED LIGANDS TO STUDY 3-ADRENERGIC RECEPTORS1 (1977) (0)
P2U-PURINOCEPTOR AGONISTS : EMERGING THERAPY FOR PULMONARY DISEASES (1998) (0)
NEURONAL AND BEHAVIORAL PLASTICITY AFTER NORADRENERGIC LESIONS IN DEVELOPING RAT (1979) (0)
β Adrenergic receptor density and isoproterenol induced desensitization of adenylate cyclase (1977) (0)
Potent and Selective Peptide-based Inhibition of the G Protein G (cid:2) q* (2016) (0)
Activated Rac1 bound to its effector phospholipase C beta 2 (2006) (0)
Competitive and selective antagonism of P2Y 1 receptors by N 6 -methyl 2 (cid:39) -deoxyadenosine 3 (cid:39) ,5 (cid:39) -bisphosphate (1998) (0)
REGULATION OF PHOSPHOLIPASE C-13 ISOENZYMES (1996) (0)
Probing the binding sites of P2X and P2Y receptors: selective antagonists and receptor structure. (2000) (0)
Instructions for Authors (2004) (0)
The Phospholipase C Linked P 2y -Purinergic Receptor (1990) (0)
Relationship between an Altered Membrane Form and a Low Affinity Form of the &Adrenergic Receptor Occurring during Catecholamine-induced Desensitization (2001) (0)
Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex (2021) (0)
Crystal structure of activated G alpha Q bound to its effector phospholipase C beta 3 (2010) (0)
The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure (2008) (0)
Activation of Phospholipase C- (cid:1) by Heterotrimeric G Protein (cid:2)(cid:3) -Subunits* (2001) (0)
Epidermal growth factor, bradykinin, and histamine stimulate inositol phosphate formation in A431 human epidermoid carcinoma cells (1986) (0)
Synthesis of base-substituted uridine 5'-phosphonate analogues as potential P2Y2 receptor ligands (2011) (0)
C-terminal Domain of Turkey PLC-beta (2001) (0)
Agonist‐promoted internalization of the P2Y1 receptor in Madin‐Darby Canine Kidney (MDCK) cells (2008) (0)
Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from G., G; and Go (2005) (0)
G-Protein Regulation of Phospholipase C in the Turkey Erythrocyte (1993) (0)
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and L-alpha-threofuranosyl ring systems: Interactions with purine/pyrimidine receptors (2004) (0)
H/sub 1/-histamine receptors regulate phosphoinositide hydrolysis in human astrocytoma cells (1986) (0)
Mechanisms of desensitization of β-adrenergic receptors (1984) (0)
Agonist and Guanine Nucleotide Regulation of P 2Y Purinergic Receptor-Linked Phospholipase C (1990) (0)
neutrophilssignaling and chemotaxis in human (2016) (0)
Agonist-induced change in the membrane form of muscarinic cholinergic receptors (MR) in astrocytoma cells (1985) (0)
Structural studies of RGS9/G{beta}5 (2008) (0)
The interaction of cholera toxin with β receptor linked adenylate cyclase (1977) (0)
Structural studies of RGS9/Gβ5 (2008) (0)

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