T. Kendall Harden
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T. Kendall Harden's Degrees
- PhD Pharmacology University of California, San Diego
- Bachelors Pharmacology University of California, San Diego
Why Is T. Kendall Harden Influential?
(Suggest an Edit or Addition)T. Kendall Harden's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Nomenclature and classification of purinoceptors. (1994) (1631)
- Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance (2009) (1335)
- Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. (2003) (576)
- Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants. (1978) (443)
- Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. (1983) (432)
- P2-purinergic receptors: subtype-associated signaling responses and structure. (1995) (362)
- Towards a revised nomenclature for P1 and P2 receptors. (1997) (361)
- Constitutive Release of ATP and Evidence for Major Contribution of Ecto-nucleotide Pyrophosphatase and Nucleoside Diphosphokinase to Extracellular Nucleotide Concentrations* (2000) (334)
- Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation* (1997) (319)
- Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. (1980) (288)
- Identification of competitive antagonists of the P2Y1 receptor. (1996) (257)
- The experimental power of FR900359 to study Gq-regulated biological processes (2015) (251)
- Second messenger cascade specificity and pharmacological selectivity of the human P2Y1‐purinoceptor (1996) (237)
- Pharmacological selectivity of the cloned human P2U‐purinoceptor: potent activation by diadenosine tetraphosphate (1995) (236)
- beta-Adrenergic receptor involvement in 6-hydroxydopamine-induced supersensitivity in rat cerebral cortex. (1976) (228)
- Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. (1985) (218)
- Competitive and selective antagonism of P2Y1 receptors by N6‐methyl 2′‐deoxyadenosine 3′,5′‐bisphosphate (1998) (212)
- Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. (1994) (189)
- Kinetic Scaffolding Mediated by a Phospholipase C–β and Gq Signaling Complex (2010) (188)
- Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. (1983) (185)
- Beta gamma-subunit activation of G-protein-regulated phospholipase C. (1992) (176)
- Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. (1989) (173)
- PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. (2003) (166)
- Agonist action of adenosine triphosphates at the human P2Y1 receptor. (1998) (162)
- Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells. (1991) (162)
- Quantitation of extracellular UTP using a sensitive enzymatic assay (1999) (156)
- Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization. (1988) (149)
- General and versatile autoinhibition of PLC isozymes. (2008) (149)
- RGS6, RGS7, RGS9, and RGS11 Stimulate GTPase Activity of Gi Family G-proteins with Differential Selectivity and Maximal Activity* (2003) (148)
- Release of cellular UDP-glucose as a potential extracellular signaling molecule. (2003) (146)
- Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. (1998) (145)
- The phospholipase C isozymes and their regulation. (2012) (144)
- Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. (1987) (142)
- Regulation of phospholipase C isozymes by ras superfamily GTPases. (2006) (142)
- Differential effects of P2‐purinoceptor antagonists on phospholipase C‐ and adenylyl cyclase‐coupled P2Y‐purinoceptors (1994) (140)
- DLC‐1 suppresses non‐small cell lung cancer growth and invasion by RhoGAP‐dependent and independent mechanisms (2008) (140)
- A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. (1997) (139)
- The Role of Amino Acids in Extracellular Loops of the Human P2Y1 Receptor in Surface Expression and Activation Processes* (1999) (132)
- HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors (1997) (131)
- Ontogeny of β-adrenergic receptors in rat cerebral cortex (1977) (130)
- Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor. (2004) (129)
- Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. (1980) (127)
- beta-adrenergic receptors in rat liver: effects of adrenalectomy. (1976) (127)
- Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. (1998) (127)
- Overview of the Alliance for Cellular Signaling (2002) (125)
- Identification of an Ecto-nucleoside Diphosphokinase and Its Contribution to Interconversion of P2 Receptor Agonists* (1997) (124)
- Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s). (1982) (124)
- Crystal structure of Rac1 bound to its effector phospholipase C-β2 (2006) (123)
- UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. (1997) (122)
- Molecular pharmacology, physiology, and structure of the P2Y receptors. (2011) (119)
- Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity. (1997) (119)
- Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase. (1993) (118)
- 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. (2003) (115)
- ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. (2000) (115)
- Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. (1982) (112)
- G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness (2012) (111)
- Development of selective agonists and antagonists of P2Y receptors (2008) (109)
- Crystal structure of the multifunctional Gβ5–RGS9 complex (2008) (109)
- Induction of Novel Agonist Selectivity for the ADP-Activated P2Y1 Receptor Versus the ADP-Activated P2Y12 and P2Y13 Receptors by Conformational Constraint of an ADP Analog (2004) (108)
- Identification of two benzodiazepine binding sites on cells cultured from rat cerebral cortex. (1981) (108)
- Supersensitivity in rat cerebral cortex: pre- and postsynaptic effects of 6-hydroxydopamine at noradrenergic synapses. (1977) (107)
- Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. (1979) (104)
- Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. (2000) (104)
- Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits. (1994) (104)
- Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells. (1978) (104)
- The Pleckstrin Homology Domain of Phospholipase C-β2 as an Effector Site for Rac* (2003) (103)
- Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits* (2001) (100)
- Regulation of Cyclic AMP Accumulation by Peptide Hormone Receptors in Immunocytochemically: Defined Astroglial Cells (1984) (99)
- Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. (1993) (97)
- Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes*♦ (2010) (96)
- Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein. (1991) (92)
- Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor. (1989) (92)
- Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. (1994) (92)
- UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. (2002) (92)
- Direct Activation of Phospholipase C-ϵ by Rho* (2003) (91)
- Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. (2004) (91)
- Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. (1984) (91)
- Pharmacological and second messenger signalling selectivities of cloned P2Y receptors. (1996) (89)
- A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq (2002) (88)
- Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes (1994) (88)
- In vitro study of beta-adrenergic receptors. (1977) (87)
- Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms. (1984) (86)
- Effects of 6-hydroxydopamine on the development of the beta adrenergic receptor/adenylate cyclase system in rat cerebral cortex. (1977) (85)
- A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. (2011) (83)
- A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils (2013) (83)
- Quantification of Gi-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y14 Receptor (2009) (82)
- Purification and functional reconstitution of the human P2Y12 receptor. (2003) (82)
- Protein Kinase C Phosphorylates RGS2 and Modulates Its Capacity for Negative Regulation of Gα11 Signaling* (2001) (82)
- 2‐Chloro N6‐methyl‐(N)‐methanocarba‐2′‐deoxyadenosine‐3′,5′‐bisphosphate is a selective high affinity P2Y1 receptor antagonist (2002) (81)
- Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. (1987) (81)
- Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. (1981) (81)
- Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart. (1976) (81)
- Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. (1985) (80)
- Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. (1985) (80)
- Signalling and pharmacological properties of the P2Y14 receptor (2010) (80)
- Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. (2002) (78)
- Functional expression of a cDNA encoding a human ecto‐ATPase (1999) (78)
- Role of Isoprenoid Lipids on the Heterotrimeric G Protein γ Subunit in Determining Effector Activation* (1999) (76)
- Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. (2005) (76)
- H1-histamine receptors on human astrocytoma cells. (1986) (76)
- Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. (2001) (76)
- Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase (2001) (75)
- UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation (2015) (73)
- Agonist-induced internalization of the P2Y2 receptor. (1998) (73)
- Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. (2002) (71)
- Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. (2001) (71)
- Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. (1988) (71)
- Adenosine receptors on human airway epithelia and their relationship to chloride secretion (1992) (70)
- Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference. (2005) (70)
- Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization. (1984) (68)
- Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. (2008) (68)
- Differential Regulation of the Uridine Nucleotide-activated P2Y4 and P2Y6 Receptors (2001) (67)
- Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. (1986) (66)
- The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery (2000) (66)
- Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain. (1982) (66)
- Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform* (2009) (64)
- Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation. (1985) (64)
- A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. (1998) (63)
- Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. (2001) (63)
- The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. (1997) (61)
- Molecular cloning and characterization of PLC‐η2 (2005) (61)
- Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C (1997) (61)
- RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism* (2004) (61)
- Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. (2006) (59)
- Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. (1984) (58)
- Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. (1989) (58)
- Gα12/13- and Rho-Dependent Activation of Phospholipase C-ϵ by Lysophosphatidic Acid and Thrombin Receptors (2006) (58)
- Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. (2002) (58)
- Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U‐purinoceptors (1996) (57)
- Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin. (1985) (57)
- Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. (1987) (57)
- Effects of dopaminergic agonists and antagonists on cerebellar guanosine-3',5'-monophosphate (cGMP). (1978) (55)
- Gi-Dependent Cell Signaling Responses of the Human P2Y14 Receptor in Model Cell Systems (2009) (54)
- Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. (1999) (54)
- Hormone and growth factor receptor-mediated regulation of phospholipase C activity. (1989) (52)
- Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate. (2000) (51)
- Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium. (1994) (50)
- Platelet‐derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells (1989) (50)
- Agonist Versus Antagonist Action of ATP at the P2Y4 Receptor Is Determined by the Second Extracellular Loop* (2004) (49)
- The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. (2012) (49)
- Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps. (1995) (49)
- Identification of potent P2Y‐purinoceptor agonists that are derivatives of adenosine 5′‐monophosphate (1996) (49)
- Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. (2007) (49)
- UDP Is a Competitive Antagonist at the Human P2Y14 Receptor (2008) (48)
- Molecular cloning and expression of an avian G protein-coupled P2Y receptor. (1997) (47)
- Regulation of P2Y1 Receptor-Mediated Signaling by the Ectonucleoside Triphosphate Diphosphohydrolase Isozymes NTPDase1 and NTPDase2 (2005) (47)
- Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. (1989) (47)
- N-Ethylmaleimide-induced alteration in the interaction of agonists with muscarinic cholinergic receptors of rat brain. (1983) (46)
- Polarized expression of human P2Y receptors in epithelial cells from kidney, lung, and colon. (2005) (46)
- Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide. (2010) (46)
- 2-Chloro N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. (2002) (46)
- Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. (2007) (45)
- Evidence that the p2y3 receptor is the avian homologue of the mammalian P2Y6 receptor. (1998) (45)
- Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. (1986) (45)
- Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor. (2011) (45)
- Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go. (1987) (45)
- Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17 (2013) (45)
- Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. (2011) (45)
- Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. (2001) (44)
- Acireductone Dioxygenase 1 (ARD1) Is an Effector of the Heterotrimeric G Protein β Subunit in Arabidopsis* (2011) (44)
- Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. (2010) (44)
- High-affinity binding of agonists to beta-adrenergic receptors on intact cells. (1983) (44)
- Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. (2006) (42)
- A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation. (2014) (41)
- A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties. (1990) (41)
- UDP-glucose promotes neutrophil recruitment in the lung (2016) (41)
- Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors (1998) (40)
- Modulation of muscarinic cholinergic receptor affinity for antagonists in rat heart. (1984) (40)
- [32P]2‐iodo‐N6‐methyl‐(N)‐methanocarba‐2′‐deoxyadenosine‐3′,5′‐bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors (2006) (40)
- A comparison of calcium-activated potassium channel currents in cell- attached and excised patches (1987) (40)
- Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni. (1985) (40)
- A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. II. P2Y-purinergic receptor and G-protein-mediated regulation of the purified enzyme reconstituted with turkey erythrocyte ghosts. (1990) (40)
- Dexamethasone increases β-adrenoceptor density in human astrocytoma cells (1980) (40)
- Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases* (2008) (39)
- Interaction of a radiolabeled agonist with cardiac muscarinic cholinergic receptors. (1983) (37)
- Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7. (1997) (37)
- Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. (1987) (37)
- Synthesis and structure‐activity relationships of pyridoxal‐6‐arylazo‐5′‐phosphate and phosphonate derivatives as P2 receptor antagonists (1998) (36)
- Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C. (1989) (36)
- Activation of human phospholipase C-eta2 by Gbetagamma. (2008) (35)
- [32P]3'-O-(4-benzoyl)benzoyl ATP as a photoaffinity label for a phospholipase C-coupled P2Y-purinergic receptor. (1990) (35)
- Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor. (2008) (35)
- Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. (2010) (34)
- Dependence of the activity of phospholipase C beta on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation. (1997) (34)
- Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation. (1983) (34)
- Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-beta. (1999) (34)
- Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes (2014) (33)
- Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists (2016) (33)
- Protein kinase C inhibits epidermal growth factor-dependent tyrosine phosphorylation of phospholipase C gamma and activation of phosphoinositide hydrolysis. (1990) (33)
- Dominant-negative Inhibition of Pheromone Receptor Signaling by a Single Point Mutation in the G Protein α Subunit* (2004) (33)
- A Guanine Nucleotide-independent Inwardly Rectifying Cation Permeability Is Associated with P2Y1 Receptor Expression in Xenopus Oocytes* (1996) (33)
- Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. (2013) (32)
- Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase. (1979) (32)
- Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. (1988) (32)
- Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. (2004) (32)
- Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13 * (2001) (32)
- Potent agonist action of 2‐thioether derivatives of adenine nucleotides at adenylyl cyclase‐linked P2y‐purinoceptors (1995) (32)
- Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. (2009) (31)
- P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. (2007) (30)
- Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500). (2010) (30)
- Noradrenergic hyperinnervation reduces the density of β-adrenergic receptors in rat cerebellum (1979) (30)
- Irreversible activation of phospholipase C-coupled P2Y-purinergic receptors by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. (1989) (30)
- Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors. (2004) (30)
- A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. (2002) (30)
- Molecular cloning and characterization of a novel beta-adrenergic receptor. (1994) (29)
- Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen* (2013) (29)
- Membrane-induced Allosteric Control of Phospholipase C-β Isozymes* (2014) (29)
- Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. (1999) (28)
- Multiple P2Y receptors mediate contraction in guinea pig mesenteric vein. (2000) (28)
- Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands (2009) (28)
- Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits. (2001) (27)
- The stable pyrimidines UDPbetaS and UTPgammaS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. (2000) (27)
- Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. (1990) (27)
- Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide. (1984) (27)
- Studies of cAMP metabolism in cultured hepatoma cells: Presence of functional adenylate cyclase despite low camp content and lack of hormonal responsiveness (1978) (27)
- Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems. (1987) (26)
- (N)‐methanocarba‐2MeSADP (MRS2365) is a subtype‐specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets (2006) (26)
- Requirement of Cys399 for Processing of the Human Ecto-ATPase (NTPDase2) and Its Implications for Determination of the Activities of Splice Variants of the Enzyme* (2003) (26)
- Release of ATP and UTP from astrocytoma cells. (1999) (26)
- Identification of Gα11 as the phospholipase C-activating G-protein of turkey erythrocytes (1993) (26)
- Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system. (2006) (25)
- Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. (1996) (24)
- Acute and Chronic Modulation of the Responsiveness of Receptor-Associated Adenylate Cyclases (1982) (24)
- Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. (2006) (23)
- Molecular cloning and characterization of PLC-eta2. (2005) (23)
- Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties (1996) (23)
- GPR80/99, proposed to be the P2Y15 receptor activated by adenosine and AMP, is not a P2Y receptor (2004) (23)
- Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition. (2009) (23)
- Concentration of enzyme-dependent activation of PLC-β1 and PLC-β2 by Gα11 and βγ-subunits (1995) (23)
- A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates. (2000) (22)
- Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells. (1986) (22)
- Purification and G Protein Subunit Regulation of a Phospholipase C-β from Xenopus laevis Oocytes* (1996) (21)
- Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. (2010) (21)
- Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations (2019) (21)
- Differential expression of components of the adenylate cyclase system during growth of astrocytoma cells in culture. (1979) (21)
- G-protein-mediated regulation of phospholipase C Involvement of βγ subunits. (1994) (21)
- Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal (2010) (20)
- Biochemical Properties of a P2Y‐Purinergic Receptor (1990) (19)
- [3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines. (1987) (19)
- 4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6 Receptors (2014) (18)
- Newly synthesized norepinephrine accumulation in the readily releasable pool of a purified adrenergic vesicle fraction. (1975) (18)
- Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor. (2015) (18)
- Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. (1996) (18)
- Effects of tunicamycin on the expression of beta-adrenergic receptors in human astrocytoma cells during growth and recovery from agonist-induced down-regulation. (1985) (18)
- Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment. (1986) (18)
- Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors. (1985) (18)
- Receptor-induced heterologous desensitization of receptor-regulated phospholipase C. (1995) (17)
- Potent and Selective Peptide-based Inhibition of the G Protein Gαq* (2016) (17)
- Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. (2000) (17)
- G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). (2001) (16)
- Guanine nucleotides modulate the affinity of antagonists at beta-adrenergic receptors. (1981) (16)
- A sensitive equilibrium binding assay for soluble beta-adrenergic receptors. (1981) (15)
- Protein Kinase C-Promoted Inhibition of Gα11-Stimulated Phospholipase C-β Activity (1999) (15)
- Nucleotides released by apoptotic cells act as a find-me signal for phagocytic clearance (2010) (15)
- Use of a density shift method to assess beta-adrenergic receptor synthesis during recovery from catecholamine-induced down-regulation in human astrocytoma cells. (1984) (15)
- Receptor nomenclature (15)
- Purification of G-protein-regulated phospholipase C from turkey erythrocytes. (1994) (14)
- C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. (2003) (14)
- Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins. (1978) (14)
- By-Subunit Activation of G-protein-regulated Phospholipase C* (2001) (14)
- G protein-dependent regulation of phospholipase C by cell surface receptors. (1990) (13)
- Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells. (1983) (13)
- Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations (2019) (13)
- Regulation of phospholipase C. (1990) (13)
- Receptor- and G-protein-regulated 150-kDa avian phospholipase C: inhibition of enzyme activity by isoenzyme-specific antisera and nonidentity with mammalian phospholipase C isoenzymes established by immunoreactivity and peptide sequence. (1991) (13)
- Acyclic Analogues of Deoxyadenosine 3′,5′‐Bisphosphates as P2Y1 Receptor Antagonists. (2000) (13)
- The G Protein-Coupled P2Y Receptors (1998) (12)
- A fusion protein of the human P2Y(1) receptor and NTPDase1 exhibits functional activities of the native receptor and ectoenzyme and reduced signaling responses to endogenously released nucleotides. (2002) (12)
- DRUG ANALYSIS BASED ON SIGNALING RESPONSES TO G-PROTEIN-COUPLED RECEPTORS (2001) (10)
- Solubilization of a Guanine Nucleotide‐Sensitive Form of the P2Y‐Purinergic Receptor from Turkey Erythrocyte Membranes (1990) (10)
- Interplay of constitutively released nucleotides, nucleotide metabolism, and activity of P2Y receptors (2001) (10)
- Ontogeny of beta-adrenergic receptors in rat cerebral cortex. (1977) (10)
- A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes (2017) (10)
- Drug-induced modification of the responsiveness of adenylate cyclase to hormones. (1978) (10)
- Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays. (1996) (10)
- Regulation of beta-adrenergic receptors in the cerebral cortex. (1978) (9)
- Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. (2013) (9)
- Muscarinic Cholinergic Receptor-Mediated Regulation of Cyclic AMP Metabolism (1989) (9)
- Adrenergic storage vesicles in rat heart: quantitation of membrane-bound and membrane-enclosed dopamine beta-hydroxylase. (1978) (9)
- Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. (2012) (9)
- Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes. (1996) (8)
- The stable pyrimidines UDPbS and UTPgS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery (8)
- RhoA Activates Purified Phospholipase C- (cid:1) by a Guanine Nucleotide-dependent Mechanism* (2004) (8)
- Development of an assay for phospholipase C using column-reconstituted, extruded phospholipid vesicles. (1999) (8)
- Dexamethasone increases beta-adrenoceptor density in human astrocytoma cells. (1980) (8)
- Regulation of cAMP metabolism, protein kinase activation, and specific enzyme synthesis in cultured hepatoma cells. (1978) (7)
- Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness (2012) (7)
- Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins (2004) (7)
- Molecular Cloning and Expression of an Avian G Protein-Coupled P 2 Y Receptor (1997) (7)
- Protein kinase C-promoted inhibition of Galpha(11)-stimulated phospholipase C-beta activity. (1999) (7)
- Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles. (2006) (7)
- Purification of an AIFT and G-protein @r-Subunit-regulated Phospholipase C-activating Protein* (2001) (7)
- Evidence that the p 2 y 3 Receptor Is the Avian Homologue of the Mammalian P 2 Y 6 Receptor (1998) (6)
- Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. (2001) (6)
- Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. (1988) (6)
- Identification of G alpha 11 as the phospholipase C-activating G-protein of turkey erythrocytes. (1993) (6)
- Purification and in vitro functional analysis of R7 subfamily RGS proteins in complex with Gbeta5. (2004) (6)
- Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats (1984) (6)
- Novel ATP Agonists Reveal Receptor Heterogeneity Within P2X and P2Y Subtypes (1995) (6)
- Serum dopamine beta-hydroxylase activity following subarachnoid hemorrhage in man. (1975) (5)
- Purification of phospholipase C-activating G protein, G11, from turkey erythrocytes. (1994) (5)
- Cyclic AMP and beta-adrenergic receptors during the development of physical dependence on ethanol in the rat. (1980) (5)
- Ser352 and Ser354 in the carboxyl terminus of the human P2Y1 receptor are required for agonist‐promoted phosphorylation and internalization in MDCK cells (2011) (5)
- Heterogeneous responses of cell Ca2+ in human airway epithelium. (1999) (5)
- Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand (2014) (5)
- Adaptive changes in the responsiveness of adenylate cyclase to catecholamines. (1979) (5)
- Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice. (1986) (5)
- [17] Expression, purification, and functional reconstitution of recombinant phospholipase C-β isozymes (1996) (5)
- CHAPTER 225 – The RGS Protein Superfamily (2003) (4)
- Purification and Functional Reconstitution of the Human P 2 Y 12 Receptor (2003) (4)
- β-Adrenergic receptor density in brains of ethanoldependent rats (1979) (4)
- Regulation of beta-adrenergic receptors during exposure of astrocytoma cells to catecholamines. (1984) (4)
- G-protein-regulated phospholipase C. Identification of component proteins. (1992) (4)
- Structures of G [alpha [superscript i1]] Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange (2010) (3)
- Epidermal Growth Factor Stimulates the Rapid Accumulation of Inositol ( 1 , 4 , 5 )-Trisphosphate and a Rise in Cytosolic Calcium Mobilized from Intracellular Stores in A 431 Cells * (2001) (3)
- Avian G-protein-regulated phospholipase C. (1991) (3)
- Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes. (1994) (3)
- Enigmatic GPCR Finds a Stimulating Drug (2013) (3)
- Kinetic Analysis of Phospholipase C Isoforms Using Phospholipid-Detergent Mixed Micelles (1995) (3)
- Depression of Atrial Contractility by Peptides Isolated from Normal and Shock Plasma 1 (1973) (3)
- The First 50 Years of Molecular Pharmacology (2015) (3)
- CATECHOLAMINE-INDUCED DESENSITIZATION OF THE β-RECEPTOR-LINKED ADENYLATE CYCLASE (1979) (2)
- Author response: Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations (2019) (2)
- C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands. (2004) (2)
- Structure-Activity Relationships of Pyridoxal Phosphate Derivatives as Potent and Selective Antagonists of P 2 X 1 Receptors (2)
- Design, Synthesis and Pharmacological Characterization of a Fluorescent Agonist of the P2Y 14 Receptor (2015) (2)
- Regulation of Phospholipase C-β Isoenzymes (1996) (2)
- Muscarinic cholinergic receptor-mediated attenuation of adenylate cyclase activity in rat heart membranes. (1985) (1)
- CHARACTERIZATION OF THE EFFICACY OF β-ADRENERGIC RECEPTOR AGONISTS IN TERMS OF THE STEADY STATE MODEL FOR THE ACTIVATION OF ADENYLATE CYCLASE (1979) (1)
- Erratum: Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein α subunit (Journal of Biological Chemistry (2004) 279 (35287-35297)) (2005) (1)
- f-Adrenergic receptors in rat liver : Effects of adrenalectomy ( iodohydroxybenzylpindolol binding / supersensitivity of adenylate cyclase / hormone receptors in liver ) (1)
- Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro. (2023) (1)
- Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits. (1995) (1)
- Molecular Recognition in the P2Y14 Nucleotide Receptor: Probing the Structurally Permissive Terminal Sugar Moiety of Uridine-5′- diphosphoglucose (2009) (1)
- Regulation of PLCbeta isoforms by Rac. (2006) (1)
- β Adrenergic receptors of intact and broken human astrocytoma cells (1976) (1)
- Regulation of PLCβ Isoforms by Rac (2006) (1)
- Faculty Opinions recommendation of G protein-coupled receptors in Anopheles gambiae. (2002) (0)
- REGULATION OF β-ADRENERGIC RECEPTORS IN HUMAN ASTROCYTOMA CELLS (1979) (0)
- Binding on ice of 125I-pindolol to control and isoproterenol-treated cells (1985) (0)
- Evidence for catecholamine-induced internalization of the β-adrenergic receptor (1980) (0)
- Contents of Volume 1 (2005) (2005) (0)
- beta-adrenergic receptor density in brains of ethanol-dependent rats. (1979) (0)
- THE USE OF RADIOLABELED LIGANDS TO STUDY β-ADRENERGIC RECEPTORS1 (1976) (0)
- G-Proteins and Signal Transduction Annual Symposium (43rd), Held in Woods Hole, Massachusetts on September 6-9, 1989 (1989) (0)
- Irreversible Activation and Photoaffinity Labeling of a P2Y‐Purinergic Receptor Coupled to Phospholipase C Activation in Turkey Erythrocyte Membranes (1990) (0)
- ATP-mimetics derived from 2 '(3 ')-C-methyladenosine as human P2Y2 agonists (2008) (0)
- G (cid:1) Association and Effector Interaction Selectivities of the Divergent G (cid:2) Subunit G (cid:2) 13 * (2001) (0)
- Faculty Opinions recommendation of The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. (2002) (0)
- UDP-glucose promotes neutrophil recruitment in the lung (2016) (0)
- G proteins and signal transduction : Society of General Physiologists, 43rd Annual Symposium : Marine Biological Laboratory, Woods Hole, Massachusetts, 6-9 September, 1989 (1990) (0)
- P2Y14 receptor‐mediated Rho activation in human neutrophils (2011) (0)
- Crystal Structure of Phospholipase C Beta 2 (2008) (0)
- 1133 – THE USE 0F DIOLABELLED LIGANDS TO STUDY 3-ADRENERGIC RECEPTORS1 (1977) (0)
- P2U-PURINOCEPTOR AGONISTS : EMERGING THERAPY FOR PULMONARY DISEASES (1998) (0)
- NEURONAL AND BEHAVIORAL PLASTICITY AFTER NORADRENERGIC LESIONS IN DEVELOPING RAT (1979) (0)
- β Adrenergic receptor density and isoproterenol induced desensitization of adenylate cyclase (1977) (0)
- Potent and Selective Peptide-based Inhibition of the G Protein G (cid:2) q* (2016) (0)
- Activated Rac1 bound to its effector phospholipase C beta 2 (2006) (0)
- Competitive and selective antagonism of P2Y 1 receptors by N 6 -methyl 2 (cid:39) -deoxyadenosine 3 (cid:39) ,5 (cid:39) -bisphosphate (1998) (0)
- REGULATION OF PHOSPHOLIPASE C-13 ISOENZYMES (1996) (0)
- Probing the binding sites of P2X and P2Y receptors: selective antagonists and receptor structure. (2000) (0)
- Instructions for Authors (2004) (0)
- The Phospholipase C Linked P 2y -Purinergic Receptor (1990) (0)
- Relationship between an Altered Membrane Form and a Low Affinity Form of the &Adrenergic Receptor Occurring during Catecholamine-induced Desensitization (2001) (0)
- Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex (2021) (0)
- Crystal structure of activated G alpha Q bound to its effector phospholipase C beta 3 (2010) (0)
- The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure (2008) (0)
- Activation of Phospholipase C- (cid:1) by Heterotrimeric G Protein (cid:2)(cid:3) -Subunits* (2001) (0)
- Epidermal growth factor, bradykinin, and histamine stimulate inositol phosphate formation in A431 human epidermoid carcinoma cells (1986) (0)
- Synthesis of base-substituted uridine 5'-phosphonate analogues as potential P2Y2 receptor ligands (2011) (0)
- C-terminal Domain of Turkey PLC-beta (2001) (0)
- Agonist‐promoted internalization of the P2Y1 receptor in Madin‐Darby Canine Kidney (MDCK) cells (2008) (0)
- Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from G., G; and Go (2005) (0)
- G-Protein Regulation of Phospholipase C in the Turkey Erythrocyte (1993) (0)
- Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and L-alpha-threofuranosyl ring systems: Interactions with purine/pyrimidine receptors (2004) (0)
- H/sub 1/-histamine receptors regulate phosphoinositide hydrolysis in human astrocytoma cells (1986) (0)
- Mechanisms of desensitization of β-adrenergic receptors (1984) (0)
- Agonist and Guanine Nucleotide Regulation of P 2Y Purinergic Receptor-Linked Phospholipase C (1990) (0)
- neutrophilssignaling and chemotaxis in human (2016) (0)
- Agonist-induced change in the membrane form of muscarinic cholinergic receptors (MR) in astrocytoma cells (1985) (0)
- Structural studies of RGS9/G{beta}5 (2008) (0)
- The interaction of cholera toxin with β receptor linked adenylate cyclase (1977) (0)
- Structural studies of RGS9/Gβ5 (2008) (0)
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