Toshio Kuroki
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Biology
Toshio Kuroki's Degrees
- PhD Biochemistry University of Tokyo
- Masters Molecular Biology University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Toshio Kuroki's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells (1994) (488)
- Regulation of terminal differentiation of cultured mouse epidermal cells by 1 alpha,25-dihydroxyvitamin D3. (1983) (468)
- Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis (1999) (432)
- A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. (1990) (394)
- High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines. (1986) (372)
- A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle (1992) (334)
- Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid. (1985) (305)
- Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. (1991) (300)
- Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. (1993) (276)
- Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. (1986) (260)
- Variable opacity (Opa) outer membrane proteins account for the cell tropisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells. (1993) (256)
- Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems. (1980) (247)
- Role of Smad4 (DPC4) inactivation in human cancer. (2003) (245)
- Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. (1994) (203)
- Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. (2000) (195)
- Frequent Mutation of β-Catenin and APC Genes in Primary Colorectal Tumors from Patients with Hereditary Nonpolyposis Colorectal Cancer (1999) (194)
- Molecular and cellular features of esophageal cancer cells (2005) (192)
- In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons. (1971) (190)
- Screening the p53 status of human cell lines using a yeast functional assay (1997) (188)
- Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. (2001) (188)
- Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons. (1972) (177)
- Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes. (1986) (167)
- Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas. (1986) (157)
- Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. (1992) (156)
- Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells. (1990) (147)
- Test for malignant transformation of rat liver cells in culture: cytology, growth in soft agar, and production of plasminogen activator. (1977) (135)
- Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. (1990) (135)
- Antirheumatic agents: novel methotrexate derivatives bearing a benzoxazine or benzothiazine moiety. (1997) (130)
- Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons. (1972) (130)
- PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. (2005) (128)
- Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. (1991) (118)
- Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells (2002) (113)
- Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα* (2002) (107)
- The recessive phenotype displayed by a dominant negative microphthalmia-associated transcription factor mutant is a result of impaired nucleation potential (1996) (106)
- Novel Protein Kinase C Isoforms Regulate Human Keratinocyte Differentiation by Activating a p38δ Mitogen-activated Protein Kinase Cascade That Targets CCAAT/Enhancer-binding Protein α* (2002) (105)
- Inhibition of Tumor Promotion in Mouse Skin by 1α,25-Dihydroxyvitamin D3 (1985) (103)
- Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines. (1977) (101)
- The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture. (1971) (98)
- Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. (1999) (93)
- Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. (1999) (92)
- Antitumor activity of the selective epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) Iressa® (ZD1839) in an EGFR‐expressing multidrug‐resistant cell line in vitro and in vivo (2002) (89)
- Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts. (1988) (87)
- Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests. (1987) (86)
- UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily (1995) (85)
- Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. (2000) (85)
- Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ (1991) (84)
- Superoxide as a signal for increase in intracellular pH (1988) (83)
- A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. (2000) (80)
- Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. (2003) (80)
- PKCα mediates TGFβ-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11 (2004) (79)
- Transformation and neoplastic development in vitro of hamster embryonic cells by 4-nitroquinoline-1-oxide and its derivatives. (1968) (79)
- Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase. (1997) (77)
- The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal (1995) (77)
- Critical importance of microsome concentration in mutagenesis assay with V79 Chinese hamster cells. (1979) (77)
- Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to DNA, RNA, and proteins of transformable cells. (1972) (77)
- UV irradiation increases ROS production via PKCδ signaling in primary murine fibroblasts (2008) (76)
- Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells. (1977) (75)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones. (1993) (74)
- Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function. (1996) (74)
- PKCη associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes (2000) (74)
- Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. (1993) (72)
- Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. (1999) (71)
- Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C. (1994) (70)
- The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation (2006) (70)
- Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Mitogenic Induction of p21Cip1 by Modulating the Protein Kinase Cδ Pathway in Vascular Smooth Muscle Cells* (2001) (69)
- Requirement of Ca2+and PKCδ for Janus Kinase 2 Activation by Angiotensin II: Involvement of PYK2 (2002) (69)
- Inhibition of chemical transformation in C3H/10T1/2 cells by protease inhibitors. (1979) (67)
- Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. (1988) (67)
- Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells. (1994) (65)
- Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation. (2002) (64)
- Regulation of metallothionein gene expression by 1 alpha,25-dihydroxyvitamin D3 in cultured cells and in mice. (1987) (64)
- Lysophosphatidylcholine Inhibits Insulin-Induced Akt Activation Through Protein Kinase C-&agr; in Vascular Smooth Muscle Cells (2002) (64)
- Colony formation of mammalian cells on agar plates and its application to Lederberg's replica plating. (1973) (62)
- Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. (2001) (59)
- Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. (2002) (57)
- PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells (2001) (57)
- PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes. (2001) (57)
- Growth and Differentiation Properties of Normal and Transformed Human Keratinocytes in Organotypic Culture (1994) (56)
- Why Are Human Cells Resistant to Malignant Cell Transformation in vitro?1 (1993) (55)
- Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin. (1997) (55)
- Direct or proximate contact between cells and metabolic activation systems is required for mutagenesis (1978) (54)
- The eta isoform of protein kinase C is localized on rough endoplasmic reticulum (1994) (54)
- Differentiation‐associated localization of small prolne‐rich rotein in normal and diseased human skin (1996) (53)
- Differential Effects of Tumor Necrosis Factor-α on Protein Kinase C Isoforms α and δ Mediate Inhibition of Insulin Receptor Signaling (2002) (52)
- Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. (2002) (52)
- Release of H2O2 and phosphorylation of 30 kilodalton proteins as early responses of cell cycle-dependent inhibition of DNA synthesis by transforming growth factor beta 1. (1991) (50)
- A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF (1993) (49)
- Absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells. (1978) (49)
- Inhibition by N‐acetyl‐l‐cysteine of interleukin‐6 mRNA induction and activation of NFκB by tumor necrosis factor α in a mouse fibroblastic cell line, Balb/3T3 (1994) (49)
- Metabolism of benzo[a]pyrene in human epidermal keratinocytes in culture. (1980) (48)
- Cholesterol sulfate activates transcription of transglutaminase 1 gene in normal human keratinocytes. (1998) (48)
- Possible functions of 1 alpha,25-dihydroxyvitamin D3, an active form of vitamin D3, in the differentiation and development of skin. (1985) (48)
- Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. (2002) (47)
- Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA. (1995) (47)
- Some factors determining the concentration of liver proteins for optimal mutagenicity of chemicals in the Salmonella/microsome assay. (1979) (46)
- Regulation of creatine phosphokinase B activity by protein kinase C. (1990) (46)
- A protective role of PKCepsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells. (2001) (46)
- gamma-Glutamyl transpeptidase and malignant transformation of cultured liver cells. (1979) (45)
- Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport. (1987) (45)
- Mutagenecity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells (1979) (44)
- Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. (1988) (44)
- Molecular evidence for multicentric development of thyroid carcinomas in patients with familial adenomatous polyposis. (2000) (42)
- The η isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes (2003) (40)
- Purification and identification of creatine phosphokinase B as a substrate of protein kinase C in mouse skin in vivo. (1990) (40)
- Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters. (1986) (40)
- The testicular fatty acid binding protein PERF15 regulates the fate of germ cells in PERF15 transgenic mice (2005) (40)
- Involucrin and SPRR are synthesized sequentially in differentiating cultured epidermal cells. (1997) (40)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. V. Thienopyridazinone derivatives. (1995) (40)
- Inhibition of Insulin-induced Activation of Akt by a Kinase-deficient Mutant of the ε Isozyme of Protein Kinase C* (2001) (39)
- Hyperplastic epithelial foci in honeycomb lesions in idiopathic pulmonary fibrosis (2002) (39)
- Alternative differentiation of human promyelocytic leukemia cells (HL-60) induced selectively by retinoic acid and 1 alpha,25-dihydroxyvitamin D3. (1985) (39)
- Hyperphosphorylation of keratins by treatment with okadaic acid of BALB/MK-2 mouse keratinocytes. (1993) (38)
- Protein Kinase Cδ-mediated Phosphorylation of α6β4 Is Associated with Reduced Integrin Localization to the Hemidesmosome and Decreased Keratinocyte Attachment (2001) (38)
- Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review. (2000) (37)
- Metabolism of benzo(a)pyrene in epidermal keratinocytes and dermal fibroblasts of humans and mice with reference to variation among species, individuals, and cell types. (1982) (35)
- Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper (1999) (35)
- Determination of the h-protein in transformable and transformed cells in culture. (1972) (35)
- Effectiveness of cervical cancer screening over cervical cancer mortality among Japanese women. (2006) (35)
- Presence of specific binding sites for phorbol ester tumor promoters in human epidermal and dermal cells in culture but lack of down regulation in epidermal cells. (1983) (34)
- Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests (1982) (33)
- Enhancement of Sensitivity to Tumor Necrosis Factor α in Non–Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib (2005) (33)
- The metabolism of benz(a)anthracene and dibenz(a,h)anthracene and their related "K-region" epoxides, cis-dihydrodiols and phenols by hamster embryo cells. (1973) (33)
- Random Segregation of DNA Strands in Epidermal Basal Cells (1989) (33)
- Cholesterol sulfate, a second messenger for the eta isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis. (1995) (32)
- Performance of short-term tests for detection of human carcinogens. (1987) (32)
- Induction by cholera toxin of synchronous divisions in vivo in the epidermis resulting in hyperplasia. (1981) (31)
- Inhibition by 1 alpha, 25-dihydroxyvitamin D3 of induction of epidermal ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate and teleocidin B. (1984) (31)
- Bacterial and mammalian mutagenicity tests: validation and comparative studies on 180 chemicals. (1980) (31)
- Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors. (1989) (30)
- Systemic inhibition of tumor promoter-induced ornithine decarboxylase in 1 alpha-hydroxyvitamin D3-treated animals. (1987) (30)
- Involvement ofSonic hedgehogin the Cell Growth of LK-2 Cells, Human Lung Squamous Carcinoma Cells (1997) (30)
- Alterations of repeated sequences in 5′ upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome (2001) (29)
- Effects of the protein kinase C inhibitor H-7 and calmodulin antagonist W-7 on superoxide production in growing and resting human histiocytic leukemia cells (U937). (1987) (29)
- Enhancement by 1α,25-Dihydroxyvitamin D3 of Chemically Induced Transformation of BALB 3T3 Cells without Induction of Ornithine Decarboxylase or Activation of Protein Kinase C (1986) (29)
- Cyclic AMP as a Mitotic Signal for Epidermal Keratinocytes, but not for Dermal Fibroblasts (1982) (28)
- Highly sensitive, specific detection of O6-methylguanine, O4-methylthymine, and O4-ethylthymine by the combination of high-performance liquid chromatography prefractionation, 32P postlabeling, and immunoprecipitation. (1992) (27)
- Dual regulation of phospholipase D1 by protein kinase C α in vivo (2002) (27)
- Differential expression of Hox genes in multistage carcinogenesis of mouse skin. (1998) (27)
- Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling. (2002) (27)
- Inhibition of DNA synthesis and sugar uptake and lack of induction of ornithine decarboxylase in human epidermal cells treated with mouse skin tumor promoters. (1984) (27)
- Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. (2001) (26)
- 1α, 25-DIHYDROXYVITAMIN D3 MARKEDLY ENHANCES CHEMICALLY-INDUCED TRANSFORMATION IN BALB 3T3 CELLS (1983) (26)
- Cell-cycle dependent phosphorylation of HSP28 by TGF beta 1 and H2O2 in normal mouse osteoblastic cells (MC3T3-E1), but not in their ras-transformants. (1992) (26)
- Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. (2001) (25)
- Resistance to 1,25-dihydroxyvitamin D3 of cultured psoriatic epidermal keratinocytes isolated from involved and uninvolved skin. (1989) (25)
- Phosphorylations of Mr 34,000 and 40,000 proteins by protein kinase C in mouse epidermis in vivo. (1988) (25)
- Protein kinase C activities and bindings of a phorbol ester tumor promoter in 41 cell lines. (1988) (24)
- Tumor‐promoting Phorbol Ester Induces Alterations of Sialidase and Sialyltransferase Activities of JB6 Cells (1990) (24)
- Identification of lamin B2 as a substrate of protein kinase C in BALB/MK-2 mouse keratinocytes. (1991) (24)
- Isolation and characterization of a novel hair follicle-specific gene, Hacl-1. (1994) (24)
- Adenovirus-mediated gene transfer to keratinocytes--a review. (1999) (24)
- The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes. (2003) (23)
- DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes. (1996) (23)
- Relationship between in-vitro cell transformation and in-vivo carcinogenesis based on available data on the effects of chemicals. (1985) (23)
- Phorbol Ester‐induced G1 Arrest in BALB/MK‐2 Mouse Keratinocytes Is Mediated by δ and η Isoforms of Protein Kinase C (1998) (22)
- Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells. (1979) (22)
- Isolation and characterization of a putative keratin-associated protein gene expressed in embryonic skin of mice. (1998) (22)
- Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. (2001) (22)
- Chapter 11 Agar Plate Culture and Lederberg-Style Replica Plating of Mammalian Cells (1975) (22)
- High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas (2002) (21)
- Malignization In Vitro of Hamster Embryonic Cells by Chemical Carcinogens (1966) (21)
- Defect in UV-induced unscheduled DNA synthesis in cultured epidermal keratinocytes from xeroderma pigmentosum. (1987) (21)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones. (1993) (20)
- Cytogenetic effects of argon laser irradiation on Chinese hamster cells. (1983) (20)
- Skin abnormality in aged fyn-/- fak+/- mice. (1997) (19)
- Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers. (2002) (19)
- Enhancement of anchorage‐independent growth of human pancreatic carcinoma MIA PaCa‐2 cells by signaling from protein kinase C to mitogen‐activated protein kinase (2002) (19)
- Inhibition of tumor promotion in mouse skin by 1 alpha,25-dihydroxyvitamin D3. (1985) (19)
- Involvement of Sonic hedgehog in the cell growth of LK-2 cells, human lung squamous carcinoma cells. (1997) (19)
- Transcriptional and Post-transcriptional Regulation of the PKCδ Gene by Etoposide in L1210 Murine Leukemia Cells: Implication of PKCδ Autoregulation (2004) (18)
- Localization and developmental expression of a novel protein kinase C delta gene. (1992) (18)
- 1 alpha,25-Dihydroxyvitamin D3 induces anchorage-independent growth and c-Ki-ras expression of BALB/3T3 and NIH/3T3 cells. (1987) (18)
- Induction of anchorage-independent growth of JB6 mouse epidermal cells by 1 alpha,25-dihydroxyvitamin D3. (1986) (18)
- Involvement of Protein Kinase C δ (PKCδ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells (2000) (18)
- Growth inhibition of SV40-transformed human keratinocytes by TGF-beta s is not linked to dephosphorylation of the Rb gene product. (1994) (17)
- Report on the 5th Japanese‐German workshop on molecular and cellular aspects of carcinogenesis (1996) (17)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. VI. Indazole derivatives. (1995) (17)
- Altered distribution of keratinization markers in epidermolytic hyperkeratosis (2005) (17)
- Involvement of Protein Kinase C d ( PKC d ) in Phorbol Ester-induced Apoptosis in LNCaP Prostate Cancer Cells (2000) (17)
- Malignant transformation of hamster embryonic cells by 4--hydroxyaminoquinoline N-oxide in tissue culture. (1967) (16)
- Carcinogenesis in tissue culture. VII. Morphological transformation of rat liver cells in NAGISA culture. (1965) (16)
- Absence of down-regulation and translocation of the eta isoform of protein kinase C in normal human keratinocytes. (1996) (16)
- Protein Kinase C α Associates with Phospholipase D1 and Enhances Basal Phospholipase D Activity in a Protein Phosphorylation-Independent Manner in Human Melanoma Cells (2003) (16)
- NEOPLASTIC TRANSFORMATION OF RAT LIVER EPITHELIAL CELLS IN CULTURE * (1980) (16)
- Growth enhancement of normal human keratinocytes by the antisense oligonucleotide of retinoblastoma susceptibility gene. (1995) (16)
- PKCδ inhibits PKCα‐mediated activation of phospholipase D1 in a manner independent of its protein kinase activity (2003) (16)
- Inter-individual variations of arylhydrocarbon-hydroxylase activity in cultured human epidermal and dermal cells. (1987) (16)
- A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours (2003) (15)
- Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling (2003) (15)
- Involvement of hydrogen peroxide in the actions of TGFβ1 (1994) (15)
- Use of human epidermal cells in the study of carcinogenesis. (1989) (15)
- Microsome-mediated mutagenesis of a Chinese hamster cell line by various chemicals (1978) (15)
- Efficient and stable gene transfer following microinjection into nuclei of synchronized animal cells progressing from G1/S boundary to early S phase. (1998) (14)
- Appearance of dark keratinocytes following intracutaneous injection of cholera toxin in mouse skin. (1985) (14)
- Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine. (1987) (13)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. IV. 2-[2-(1-Imidazolyl)ethyl]-4-(3-pyridyl)-1(2H)-phthalazinones. (1994) (13)
- Regulation of cell differentiation and tumor promotion by 1 alpha,25 dihydroxyvitamin D3. (1985) (13)
- Dual regulation of phospholipase D1 by protein kinase C alpha in vivo. (2002) (13)
- Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes. (2010) (13)
- Genetic differences in metabolism of benzo(a)pyrene in cultured epidermal and dermal cells of responsive and nonresponsive mice. (1983) (13)
- Reduced levels of UV-induced unscheduled DNA synthesis in epidermal keratinocytes of patients with xeroderma pigmentosum and correlation with development of skin neoplasms. (1989) (13)
- Levels of protein kinase C activity in human gastrointestinal cancers. (1989) (12)
- Rapid phosphorylation of 28-kDa heat-shock protein by treatment with okadaic acid and phorbol ester of BALB/MK-2 mouse keratinocytes. (1993) (12)
- Insulin Stimulates PKCζ-mediated Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) (2001) (12)
- Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF kappa B by tumor necrosis factor alpha in a mouse fibroblastic cell line, Balb/3T3. (1994) (12)
- Metabolism of benzo[a]pyrene and other carcinogens in mouse epidermal keratinocytes in culture. (1982) (11)
- Mutagenicity of some N- and O-acyl derivatives of N-hydroxy-2-aminofluorene in V79 Chinese hamster cells. (1979) (11)
- Specific induction of ACNU-resistance in V79 Chinese hamster cells and C6 rat glioma cells. (1987) (11)
- Differential regulation of α6β4 integrin by PKC isoforms in murine skin keratinocytes (2004) (11)
- A Ca(2+)-independent protein kinase C, nPKC eta: its structure, distribution and possible function. (1992) (10)
- A highly sensitive and specific method for quantitation of O-alkylated DNA adducts and its application to the analysis of human tissue DNA. (1993) (10)
- A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. (1993) (10)
- Synthetic Studies on Spiroketal Natural Products. II. An Enantioselective Synthesis of (R)- and (S)-1,7-Dioxaspiro[5.5]undecane (1988) (10)
- Mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl. (2007) (10)
- Induction of c‐fos proto‐oncogene by a chemotactic peptide in human peripheral granulocytes (1987) (10)
- UV-induced unscheduled DNA synthesis in cultured human epidermal and dermal cells. (1985) (10)
- Mutagenesis assays with mammalian cells. (1980) (9)
- Synthetic Studies on Spiroketal Natural Products. III. Enantioselective Synthesis of 1, 6-Dioxaspiro [4.5] decane Compounds (1988) (9)
- Second japanese‐german workshop on molecular and cellular aspects of carcinogenesis (1990) (9)
- Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. (1991) (8)
- Chromosomal alteration and the development of tumors. XX. Chromosome change in the course of malignant transformation in vitro of hamster embryonic cells by 4-nitroquinoline 1-oxide and its derivative, 4-hydroxyaminoquinoline 1-oxide. (1970) (8)
- Cholera toxin, a potent inducer of epidermal hyperplasia but with no tumor promoting activity in mouse skin carcinogenesis. (1986) (7)
- Effects of dibutyryl cyclic adenosine 3′: 5′ monophosphate and theophylline on 2‐deoxy‐D‐glucose and 2‐aminoisobutyric acid uptake by hamster embryo cells (1974) (7)
- Benzo[a]pyrene metabolites: formation in rat liver cell-culture lines, binding to macromolecules, and mutagenesis in V79 hamster cells. (1982) (7)
- Report on the fourth Japanese‐German workshop on molecular and cellular aspects of carcinogenesis (1992) (7)
- Protein kinase C alpha associates with phospholipase D1 and enhances basal phospholipase D activity in a protein phosphorylation-independent manner in human melanoma cells. (2003) (7)
- Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. (2004) (7)
- Short-term assays to predict carcinogenicity. In-vitro assays that may be predictive of tumour-promoting agents. (1986) (6)
- Use of Human Epidermal Keratinocytes in Studies on Chemical Carcinogenesis (1980) (6)
- Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. Part 5. Thienopyridazinone Derivatives. (1995) (6)
- Protein Kinase Cα Is Implicated in Cholecystokinin-Induced Activation of 70-kd S6 Kinase in AR42J Cells (2005) (6)
- Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes. (2004) (6)
- 1 alpha,25-Dihydroxyvitamin D3 markedly enhances chemically-induced transformation in BALB 3T3 cells. (1983) (6)
- Genetic analysis of shiga-toxigenic Escherichia coli isolates from cattle in a limited region (2004) (6)
- Carcinogenesis and Chemotherapy—Cancer's Continuing Core Challenges: Third Charles Heidelberger Symposium (1990) (5)
- Synthetic Studies on Spiroketal Natural Products. I. : A Stereoselective Synthesis of (2R*, 5R*)- and (2R*, 5S*)-2-Methyl-1, 6-dioxaspiro[4.5]decane (1988) (5)
- Partial synchronization of hamster embryonic cells in secondary culture. (1970) (5)
- Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics. (2009) (5)
- Characteristics of an inbred substrain (C3H/HeNSa) of C3H mouse, with reference to the mammary cancer incidence and metastasis. (1965) (5)
- 8 – Comparative Mutagenicity of Diol Epoxides of Benzo[a]pyrene and Benz[a]anthracene in V79 Chinese Hamster Cells and Salmonella typhimurium (1978) (5)
- Actions of 1α,25‐Dihydroxyvitamin D3 on Normal, Psoriatic, and Promoted Epiderma1 Keratinocytes a (1988) (5)
- Induction of anchorage-indepdent growth of mouse JB6 cells by chlora toxin (1987) (4)
- Respiration and Glycolysis of Cells Transformed with 4-Nitroquinoline-1-Oxide and Its Derivative (1970) (4)
- Expression of protein kinase C isoforms in skin papilloma and carcinoma of mice. (1994) (4)
- Detection of O4-ethylthymine in human liver DNA. (1988) (4)
- Early events in in vitro carcinogenesis with 4-nitroquinoline 1-oxide. II. Mode of incorporation and binding of the carcinogen. (1970) (4)
- Antirheumatic agents. II. Novel methotrexate derivatives bearing an alkyl-substituted benzene ring. (1996) (4)
- Peroxisome Proliferator-activated Receptor Ligands Inhibit Mitogenic Induction of p 21 Cip 1 by Modulating the Protein Kinase C Pathway in Vascular Smooth Muscle Cells * (2001) (4)
- Similarity and dissimilarity between phorbol ester tumor promoters and 1 alpha,25-dihydroxyvitamin D3, an active form of vitamin D3. (1983) (4)
- Assignment1 of protein kinase Cη (Pkch) to mouse chromosome band 12C3–D2 by in situ hybridization (1998) (4)
- Monoclonal antibody-mediated solid-phase assay for mammalian O6-alkylguanine DNA alkyltransferase activity. (1991) (4)
- Development of a 3T3-like line from an embryo culture of an inbred strain of Syrian golden hamster. (1975) (4)
- In vitro carcinogenesis by 4-nitroquinoline 1-oxide and related compounds. (1981) (3)
- Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. III. 4-[2-(5-ethyl-2-thienyl)]-2'-[2-(1-imidazolyl)ethyl]-1(2H)- phthalazinones. (1994) (3)
- Studies on early events in in vitro carcinogenesis with 4-nitroquinoline 1-oxide. I. Effect on macromolecular synthesis and cell life cycle. (1969) (3)
- Photochemical cycloaddition of benzophenone to 7-methylenetetracyclo-[3.3.0.0.2,804,6]octan-3-one and its alcohol derivative (1980) (3)
- Cholera Toxin as a Mitotic Stimulator of Epidermal Cells in vitro and in vivo (1985) (3)
- Seventh Japanese–German workshop on molecular and cellular aspects of carcinogenesis (2000) (3)
- Report on the third Japanese‐German workshop on molecular and cellular aspects of carcinogenesis (1992) (3)
- PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity. (2003) (3)
- Increased production of interleukin-10 by human blood monocytes stimulated with Mycobacterium avium-intracellulare complex. (1998) (3)
- Short-term assays to predict carcinogenicity. Mammalian cell transformation in culture. (1986) (3)
- Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. Part 2. 4-(3-Pyridyl)-1(2H)- phthalazinones. (1994) (2)
- Contribution of Japanese investigators to studies on chemical transformation in vitro. (1982) (2)
- PHOTOCHEMICAL CYCLOADDITION OF BENZOPHENONE TO 7‐METHYLENETETRACYCLO(3.3.0.02,8.04,6)OCTAN‐3‐ONE AND ITS ALCOHOL DERIVATIVE (1980) (2)
- Induction of anchorage-independent growth of mouse JB6 cells by cholera toxin. (1987) (2)
- Culture-independent detection of 'TM7' bacteria in a streptomycin-resistant acidophilic nitrifying process (2014) (2)
- Further studies on the isozyme patterns of branched-chain amino acid transminase in cultured rat hepatocytes. (1976) (2)
- Cycloadditions of constrained dicyclopropylethylenes and divinylcyclopropanes with tetracyanoethylene. (1982) (2)
- Metabolic activation of benzo a pyrene in human and mouse skin cells (1982) (2)
- Immunohistochemical demonstration of novel protein kinase Cη in normal human skin and skin diseases (1992) (2)
- Synthesis of tritiated N-[4-(2,4-diaminopteridine-6-methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl]-L-homo glutamic acid (MX-68) (1997) (2)
- Growth and differentiation properties of normal human keratinocytes in organotypic culture (1993) (2)
- Enhancement by 1 alpha,25-dihydroxyvitamin D3 of chemically induced transformation of BALB 3T3 cells without induction of ornithine decarboxylase or activation of protein kinase C1. (1986) (2)
- [TISSUE CULTURE OF ASCITES HEPATOMA]. (1965) (1)
- Insulin stimulates PKCζ -mediated phosphorylation of insulin receptor substrate-1 (IRS-1): A self-attenuated mechanism to negatively regulate the function of IRS proteins. (2018) (1)
- Detection ofO4-Alkylthymine in Human Liver DNA: Molecular Epidemiological Study on Human Cancer (1990) (1)
- Carcinogenesis Protein Kinase C , Inhibits Promotional Phase in Mouse Skin Isoform of η Cholesterol Sulfate , a Second Messenger for the Updated (2006) (1)
- Studies on in vitro growth of Yoshida sarcoma cells. 3. Virulence of the long-term cultured cells. (1966) (1)
- Mammalian Cell Mutagenesis: Relevance For Detection of Environmental Mutagens/Carcinogens (1983) (1)
- Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. Part 1. 2-(2-(1-Imidazolyl) alkyl)-1(2H)-phthalazinones. (2010) (1)
- Effect of TV-02 on the differentiation and the proliferation of epidermal keratinocytes (1991) (1)
- Actions of 1 alpha,25-dihydroxyvitamin D3 on normal, psoriatic, and promoted epidermal keratinocytes. (1988) (1)
- Report on the 5th Japanese-German Workshop on molecular and cellular aspects of carcinogenesis. (1996) (1)
- STUDIES ON TISSUE CULTURE OF ASCITES TUMORS (1966) (1)
- Induction of Hyperplasia of Mouse Epidermis by Cholera Toxin (1981) (1)
- Activation, down-regulation and target proteins of protein kinase C in tumour-promotion systems in vitro. (1988) (1)
- Mouse Skin Carcinogenesis Wound Healing and Enhancement of Tumor Formation in Results in Impairment of η Disruption of Protein Kinase C Updated Version (2003) (1)
- STUDIES ON IN VITRO GROWTH OF YOSHIDA SARCOMA CELLS. I. CULTURE OF A SMALL NUMBER OF CELLS WITH REFERENCES TO THE ROLE OF ERYTHROCYTES. (1965) (1)
- Fremgangsmdåer and pharmaceutical compositions for wound healing (2001) (0)
- Isolation of a putative hair follicle-associated gene from mouse skin (1992) (0)
- IV-6 Malignant Transformation Induced by Chemicals (1984) (0)
- Difference of EGFR-Binding Wild Type and Mutant EGFR Proteins between (0)
- A Case of Focal Cancer of the Rectum without Microsatellite Instability: The Personal Experience of a Basic Researcher (1995) (0)
- Derive de methotrexate (1993) (0)
- Predominant expression of nPKCη, a newly isolated Ca2+-independent protein kinase C in mouse skin (1991) (0)
- Colorectal Cancer NonpolyposisColorectal Tumors from Patients with Hereditary Genes in Primary APC and-Catenin β Frequent Mutation of Updated Version (1999) (0)
- Microsome-mediatedMutagenesisin V79ChineseHamsterCells by Various Nitrosamines1 (1977) (0)
- Overexpression of PKCδ and PKCζ regulates α6β4 down regulation and function in skin keratinocytes (1998) (0)
- 548 POSTER Active mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl ubiquitin ligase (2006) (0)
- Protein kinase C d amplifies ceramide formation via mitochondrial signaling in prostate cancer cells (2018) (0)
- Elucidation of the gefitinib (‘Iressa’, ZD1839)-resistant mechanisms in acquired gefitinib-resistant human non-small-cell lung cancer cell lines (2004) (0)
- A New MemberoftheProtein Kinase C Family, nPKCO, Predominantly Expressed inSkeletal Muscle (1992) (0)
- Inhibition of Chemical Transformation in C3H/1OT% Cells by Protease Inhibitors1 (2006) (0)
- Development of a 3 T 3-like Line from an Embryo Culture of an Inbred Strain of Syrian Golden Hamster 1 (2006) (0)
- Assessment of mutagenicity by a combined approach with different test systems: absence of genetic activity of the antischistosomal drug Praziquantel (1979) (0)
- Methods and pharmaceutical compositions for wound healing (2001) (0)
- [Strategy against cancer in 21 century, with emphasis of cancer prevention and refractory cancer]. (2002) (0)
- PL-3 Can we overcome cancer in the 21^ century? (2001) (0)
- Novel protein kinase Cη in human skin and skin diseases (1991) (0)
- Cloning of a putative keratin-associated protein cDNA expressed in various mouse tissues other than hair follicles (1998) (0)
- Evaluation of carcinogenic risks to humans: a list of the IARC. (1994) (0)
- [Chemical carcinogenesis in vitro. 2]. (1970) (0)
- ACTIVATION AND GLUCURONIDATION IN BENZO [a] PYRENE METABOLISM (1981) (0)
- KGF, rather than HGF, is a paracrine growth factor in the three-dimensional culture conditions (1998) (0)
- , Asia Glucose Transport in Skeletal Muscle GLUT 4 Compartment and Increases Serine Phosphorylation of VAMP 2 in the Induces ζ Activation of Protein Kinase (2001) (0)
- A New Inbred Substrain“C3H/HeNSa” (1965) (0)
- Studies on tissue culture of ascites tumors.-4-Establishment and characteristics of the cultured cell lines from mouse ascites hepatoma MH-129P and MH-129F (1966) (0)
- Antirheumatic Agents. Part 2. Novel Methotrexate Derivatives Bearing an Alkyl‐Substituted Benzene Ring. (1997) (0)
- STUDIES ON TISSUE CULTURE OF ASCITES TUMORS. IV. ESTABLISHMENT AND CHARACTERISTICS OF THE CULTURED CELL LINES FROM MOUSE ASCITES HEPATOMA MH-129P AND MH-129F*1 (2008) (0)
- Process for preparing alpha-substituted ureido benzyl penicillin derivatives (1984) (0)
- Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. Part 3. 4‐(2‐(5‐Ethyl‐2‐ thienyl))‐2‐(2‐(1‐imidazolyl)ethyl)‐1(2H)‐phthalazinones. (1995) (0)
- [Advances in tissue culture technics - with special reference to application to cancer research]. (1974) (0)
- Effects of 1α,24(R)-dihydroxyvitamin D3 on the differentiation and the proliferation of epidermal keratinocytes and on the serum calcium level in rats (1990) (0)
- 096 A wound healing model in organotypic culture of human skin (1996) (0)
- Photochemical Cycloaditions of Benzophenone with Rigid Dicyclopropylethylenes--Substituent Effect on the Rearrangement of Radicals Having Tetracyclo〔3.3.0.0.2,804,6〕 octan Skeleton (1983) (0)
- Enhancement of Epidermal Growth Factor Receptor-degradation Pathway in Acquired Gefitinib-resistant Human Non-small Cell Lung Cancer Cell Lines (2004) (0)
- Metabolic Activation of Benzo [α] pyrene in Human and Mouse Skin Cells (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology) (1982) (0)
- Eighth Japanese‐German Workshop on Molecular and Cellular Aspects of Carcinogenesis1 (2002) (0)
- Difference of binding-affinity for gefitinib between wild type EGFR and a mutant EGFR (2007) (0)
- 100 Years of Cancer Research in Japan (2013) (0)
- A Cat-Independent Protein Kinase nPKC v : Its Structure , Distribution Possible Function (2006) (0)
- Advances on cancer medical care. II. Diagnosis and disease state of cancer. 1. Cancer as gene diseases. (1996) (0)
- The Tomizo Yoshida Prize. (1993) (0)
- Difference of EGFR-Binding Proteins between Wild Type and Mutant EGFR (2009) (0)
- Inhibition of DMA Synthesis and Sugar Uptake and Lack of Induction of Ornithine Decarboxylase in Human Epidermal Cells Treated with Mouse Skin Tumor Promoters1 (2006) (0)
- Regulation of growth and differentiation of normal and psoriatic epidermal keratinocytes (1990) (0)
- Isolation and characterization of a mouse hair follicle-specific gene (1993) (0)
- Modulation of cell differentiation and tumor promotion by vitamin D compounds (1986) (0)
- Isolation and characterization of mouse differentiation-specific SPR genes (cDNAs) (1993) (0)
- Molecular and Cellular Aspects of Chemical Carcinogenesis (1995) (0)
- Receptor Gene in Human Squamous Carcinoma Cell Lines High Incidence of Amplification of the Epidermal Growth Factor Updated (2006) (0)
- Methodes et compositions pharmaceutiques de cicatrisation de lesions (2001) (0)
- Microsome-mediated mitagenesis of a Chinese hamster cell line by nitrosamines (1977) (0)
- y-GlutamylTranspeptidaseand MalignantTransformationof Cultured LiverCells1 (1979) (0)
- PHARMACOLOGICAL ACTION OF l,24R(OH)2D3 IN EPIDERMAL CELL (1991) (0)
- The effect of argon laser on mammalian cells (1982) (0)
- [Carcinogenesis at the cell level. In vitro study of carcinogenesis by carcinogens. (1)]. (1970) (0)
- [Discoveries of oncogenes and tumor suppressor genes]. (1997) (0)
- Protein Kinase C a Associates with Phospholipase D 1 and Enhances Basal Phospholipase DActivity in a Protein Phosphorylation-Independent Manner in Human Melanoma Cells (2010) (0)
- REGULATION OF GROWTH BY TRANSFORMING GROWTH FACTOR-β IN NORMAL AND TRANSFORMED EPITHELIAL CELLS (1994) (0)
- Drug Accumulation and Efflux Do not Contribute to Acquired Gefitinib Resistance (2009) (0)
- [The role of epidemiology and experiments in the study of carcinogenesis]. (1986) (0)
- Synthetic Studies on Spiroketal Natural Products. Part 3. Enantioselective Synthesis of 1,6-Dioxaspiro(4.5)decane Compounds. (1989) (0)
- [Oncogenes, their implications in cell growth, differentiation and carcinogenesis]. (1987) (0)
- Studies on interaction of 4-nitroquinoline 1-oxide with RNA of hamster embryo cells. (1974) (0)
- 122 Use of adenovirus vector in the study of skin morphogenesis (1996) (0)
- Synthetic Studies on Spiroketal Natural Products. Part 2. An Enantioselective Synthesis of (R)- and (S)-1,7-Dioxaspiro(5.5)undecane. (1989) (0)
- Differentiation-associated localization of spr1 in normal human skin and skin diseases (1994) (0)
- Shoko Isoforms of Protein Kinase C δ and η Adenovirus-Mediated Introduction of the Human Keratinocytes by Induction of Differentiation in Normal (1998) (0)
- Gefitinib Cytotoxicity in Non-small Cell Lung Cancer Cells is Enhanced by Low Dose Cisplatin Due to Ligand-independent EGFR Autophosphorylation (2007) (0)
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What Schools Are Affiliated With Toshio Kuroki?
Toshio Kuroki is affiliated with the following schools: