Thomas M. Saba
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Thomas M. Sababiology Degrees
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Philosophy Biology
Thomas M. Saba's Degrees
- PhD Biochemistry University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Thomas M. Saba Influential?
(Suggest an Edit or Addition)Thomas M. Saba's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. (1980) (457)
- Physiology and physiopathology of the reticuloendothelial system. (1970) (416)
- Reference sample method for cardiac output and regional blood flow determinations in the rat. (1976) (237)
- Cryoprecipitate reversal of opsonic alpha2-surface binding glycoprotein deficiency in septic surgical and trauma patients. (1978) (176)
- Biochemical and immunological characterization of human opsonic alpha2SB glycoprotein: its identity with cold-insoluble globulin. (1978) (151)
- Opsonic Glycoprotein (Plasma Fibronectin) Levels after Burn Injury Relationship to Extent of Burn and Development of Sepsis (1980) (131)
- Opsonic α2 Surface Binding Glycoprotein Therapy During Sepsis (1978) (126)
- PHYSIOLOGIC ROLE OF COLD‐INSOLUBLE GLOBULIN IN SYSTEMIC HOST DEFENSE: IMPLICATIONS OF ITS CHARACTERIZATION AS THE OPSONIC α2‐SURFACE‐BINDING GLYCOPROTEIN * (1978) (123)
- Reticuloendothelial blockade and recovery as a function of opsonic activity. (1969) (106)
- Humoral deficiency and reticuloendothelial depression after traumatic shock. (1976) (97)
- Hepatocyte Injury During Post‐Operative Sepsis: Activated Neutrophils as Potential Mediators (1988) (90)
- Evaluation of a rapid immunoturbidimetric assay for opsonic fibronectin in surgical and trauma patients. (1981) (79)
- Cardiovascular hemodynamics after opsonic alpha-2-surface binding glycoprotein therapy in injured patients. (1979) (73)
- Deficits in reticuloendothelial humoral control mechanisms in patients after trauma. (1976) (72)
- Von Willebrand Factor (VIII R: Ag), Fibronectin, and Insulin-like Growth Factors I and II in Diabetic Retinopathy and Nephropathy (1984) (60)
- Opsonic Fibronectin Deficiency and Sepsis: Cause or Effect? (1982) (59)
- Kinetics of endogenously labeled plasma fibronectin: incorporation into tissues. (1983) (57)
- Electroimmunoassay of alpha-2-opsonic protein during reticuloendothelial blockade. (1977) (54)
- Reticuloendothelial Clearance of Blood‐borne Particulates: Relevance to Experimental Lung Microembolization and Vascular Injury (1980) (54)
- Prevention of Liver Reticuloendothelial Systemic Host Defense Failure After Surgery by Intravenous Opsonic Glycoprotein Therapy (1978) (53)
- Isolation and biochemical characterization of alpha-2-opsonic glycoprotein from rat serum. (1977) (53)
- Decreased resistance to intravenous tumour-cell challenge during reticuloendothelial depression following surgery. (1976) (52)
- Reversal of Fibronectin and Opsonic Deficiency in Patients (1984) (51)
- Mechanism of acute depletion of plasma fibronectin following thermal injury in rats. Appearance of a gelatinlike ligand in plasma. (1984) (51)
- Fibronectin fragments released from phorbol ester-stimulated pulmonary artery endothelial cell monolayers promote neutrophil chemotaxis. (1991) (51)
- Plasma fibronectin synthesis in normal and injured humans as determined by stable isotope incorporation. (1989) (49)
- Disturbances in circulating opsonic activity in man after operative and blunt trauma. (1977) (49)
- Fibronectin attenuates increased endothelial monolayer permeability after RGD peptide, anti-alpha 5 beta 1, or TNF-alpha exposure. (1995) (48)
- TNF-α disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin (2002) (47)
- Influence of opsonic fibronectin deficiency on lung fluid balance during bacterial sepsis. (1980) (45)
- Opsonic fibronectin deficiency in the etiology of starvation-induced reticuloendothelial phagocytic dysfunction. (1982) (43)
- Dynamics of insulin secretion and resistance after burns. (1977) (41)
- Effect of fibronectin on permeability of normal and TNF-treated lung endothelial cell monolayers. (1993) (41)
- PROPERTIES OF THE OPSONIC SYSTEM REGULATING IN VITRO HEPATIC PHAGOCYTOSIS. (1966) (40)
- Effect of endotoxin on fibronectin and kupffer cell activity (1985) (40)
- Purification and biochemical characterization of a macrophage stimulating alpha-2-globulin opsonic protein. (1976) (39)
- Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: Possible pathway for fibronectin deposition and turnover in the rat liver (1998) (38)
- Correction of serum opsonic defects after burn and sepsis by opsonic fibronectin administration. (1983) (38)
- Increased recycling of (alpha)5(beta)1 integrins by lung endothelial cells in response to tumor necrosis factor. (2000) (37)
- Defects in peripheral oxygen utilization following trauma and shock. (1981) (37)
- Fibronectin and phagocytic host defense: relationship to nutritional support. (1983) (36)
- Humoral mediated macrophage response during tumour growth. (1975) (34)
- Surgical stess and reticuloendothelial function. (1969) (34)
- Reticuloendothelial systemic response to operative trauma as influenced by cryoprecipitate or cold-insoluble globulin therapy. (1979) (33)
- Opsonic fibronectin after trauma and particle injection determined by a peritoneal macrophage monolayer assay. (1981) (33)
- Platelet removal from the circulation by the liver and spleen. (1978) (33)
- Reversal of opsonic deficiency in surgical, trauma, and burn patients by infusion of purified human plasma fibronectin. Correlation with experimental observations. (1986) (32)
- Lung Vascular Permeability after Reversal of Fibronectin Deficiency in Septic Sheep: Correlation with Patient Studies (1983) (31)
- Increased creatinine clearance following cryoprecipitate infusion in trauma and surgical patients with decreased renal function. (1980) (31)
- Role of alpha(v)beta(3)-integrin in TNF-alpha-induced endothelial cell migration. (2002) (31)
- Role of αvβ3-integrin in TNF-α-induced endothelial cell migration (2002) (31)
- Decreased plasma fibronectin during starvation in man. (1984) (30)
- Plasma fibronectin therapy and lung protein clearance with bacteremia after surgery. (1987) (29)
- Blood-borne collagenous debris complexes with plasma fibronectin after thermal injury. (1990) (29)
- Normal Fibronectin Levels as a Function of Age in the Pediatric Population (1983) (29)
- Purification of alpha-2-opsonic protein from human serum and its measurement by immunoassay. (1978) (28)
- Incorporation of fibronectin into matrix decreases TNF-induced increase in endothelial monolayer permeability. (1993) (28)
- Hormonal influences on reticuloendothelial development in the rat. (1977) (27)
- Extracellular matrix incorporation of normal and NEM-alkylated fibronectin: liver and spleen deposition. (1995) (26)
- Advances in shock research (1979) (26)
- Low-grade intravascular coagulation and reticuloendothelial function. (1978) (26)
- Involvement of the Opsonic System in Starvation Induced Depression of the Reticuloendothelial System∗ (1968) (25)
- Method for collection and determination of 14CO-2 for in vitro metabolic studies. (1966) (25)
- Humoral Recognition Deficiency in the Etiology of Reticuloendothelial Depression Induced by Surgery (1973) (23)
- Isolation, purification and characterization of opsonic protein. (1973) (23)
- Pathophysiology of the reticuloendothelial system (1981) (22)
- Comparative disappearance and localization of isotopically labeled opsonic protein and soluble albumin following surgical trauma. (1976) (22)
- TNF-alpha disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin. (2002) (22)
- Matrix fibronectin disruption in association with altered endothelial cell adhesion induced by activated polymorphonuclear leukocytes. (1986) (22)
- Human host defense mechanisms as they relate to surgery and trauma. (1980) (22)
- Fibronectin‐Enhanced Attachment of Gelatin‐Coated Erythrocytes to Isolated Hepatic Kupffer Cells (1984) (20)
- Evaluation of humoral and cellular mechanisms of methyl palmitate induced reticuloendothelial depression. (1968) (20)
- Phagocytosis of gelatinized "R. E. test lipid emulsion" by Kupffer cells: electronmicroscopic observations. (1976) (19)
- Reticuloendothelial phagocytic response to bacterial challenge after traumatic shock. (1977) (18)
- Transglutaminase-mediated fibronectin multimerization in lung endothelial matrix in response to TNF-alpha. (2000) (18)
- Correlation of Plasma Lysosomal Enzyme Levels with Hepatic Reticuloendothelial Function after Trauma 1 (1976) (18)
- Pulmonary Gas Exchange Abnormalities Following Intravascular Coagulation Reticuloendothelial Involvement (1980) (17)
- Plasma fibronectin. (1986) (17)
- Fibronectin levels during intraperitoneal inflammation (1983) (17)
- Circulating immunoreactive and bioassayable opsonic plasma fibronectin during experimental tumour growth (1980) (17)
- Fibronectin attenuates increased endothelial monolayer permeability after RGD peptide, anti-α5β1, or TNF-α exposure (1995) (17)
- An affinity method for the rapid purification of opsonic alpha 2 SB glycoprotein from serum. (1979) (17)
- Ventilation-perfusion relationships with high cardiac output in lobar atelectasis. (1981) (17)
- Actin-induced reticuloendothelial phagocytic depression as mediated by its interaction with fibronectin. (1983) (17)
- Effect of surgical trauma on the clearance and localization of blood-borne particulate matter. (1972) (16)
- Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor. (1999) (16)
- Fibronectin as a co-factor necessary for optimal granulocyte phagocytosis of Staphylococcus aureus. (1981) (16)
- Influence of Gelatin on Bioassayable and Immunoreactive Opsonic Fibronectin 1 (1981) (16)
- Kinetics of Plasma Fibronectin: Relationship to Phagocytic Function and Lung Vascular Integrity (1989) (16)
- Proteolysis of Gelatin‐Bound Fibronectin by Activated Leukocytes: A Role for Leukocyte Elastase (1991) (15)
- Progressive Loss of Fibronectin‐Mediated Opsonic Activity in Plasma Cryoprecipitate with Storage (1988) (15)
- Release of fibronectin fragments from endothelial cell monolayers exposed to activated leukocytes: relationship to plasma fibronectin levels after particle infusion. (1988) (15)
- Mechanism Mediating Reticuloendothelial System Depression After Surgery 1 (1970) (15)
- High‐Affinity Binding of Fibronectin to Cultured Kupffer Cells (1990) (14)
- Evaluation of the mechanism of glucan-induced stimulation of the reticuloendothelial system. (1970) (14)
- Clearance from the vascular compartment of endogenously labelled plasma fibronectin. (1984) (14)
- Lung Vascular Injury with Protease Infusion Relationship to Plasma Fibronectin (1985) (14)
- Inhibition of Phagocytosis and Glucose Metabolism of Alveolar Macrophages during Pulmonary Tumour Growth (1977) (14)
- Opsonin Depletion after Surgery (1970) (14)
- Kinetics of plasma fibronectin: increased lung tissue incorporation after postoperative bacteremia. (1991) (14)
- Fibronectin fragments in lung lymph after thrombin-induced lung vascular injury. (1989) (13)
- Immunofluorescent analysis of plasma fibronectin incorporation into the lung during acute inflammatory vascular injury. (1993) (13)
- Leukocyte involvement in pulmonary localization of blood-borne microparticulates: relationship to altered lung fluid balance. (1984) (13)
- Incorporation of circulating fibronectin into various tissues during sepsis: colocalization with endogenous tissue fibronectin. (1991) (13)
- Liver and spleen phagocytic depression after peripheral ischemia and reperfusion. (1992) (12)
- Heparin induced alterations in clearance and distribution of blood-borne microparticles following operative trauma. (1979) (12)
- Effect of x-irradiation on reticuloendothelial phagocytic function and serum opsonic activity. (1969) (12)
- Clearance and tissue distribution of fibronectin in septic rats: relationship to synthetic rate. (1986) (12)
- Kupffer cell phagocytosis and metabolism of a variety of particles as a function of opsonization. (1965) (12)
- Role of v3 -integrin in TNF--induced endothelial cell migration (2002) (12)
- Opsonic alpha2 surface binding glycoprotein therapy during sepsis. (1978) (11)
- Simultaneous measurement of fluid and protein permeability in isolated rabbit lungs during edema. (1992) (11)
- Lung matrix incorporation of plasma fibronectin reduces vascular permeability in postsurgical bacteremia. (1999) (11)
- Effect of surgical trauma on host defense. (1975) (11)
- Release of ED1 fibronectin from matrix of perfused lungs after vascular injury is independent of protein synthesis. (1993) (11)
- Alteration of tumor growth by a purified alpha-2-glycoprotein. (1977) (11)
- Hepatic removal of 125I‐DLT gelatin after burn injury: a model of soluble collagenous debris that interacts with plasma fibronectin (1993) (10)
- Effect of repetitive low‐dose endotoxin on liver parenchymal and kupffer cell fibronectin release (1989) (10)
- Isoproterenol decreases protein permeability in edematous isolated rabbit lungs: estimation of PS and sigma. (1994) (10)
- Deficient Serum Opsonic Activity for Macrophage Function in Newborn Infants 1 (1973) (10)
- Neutrophil-mediated lung localization of bacteria: a mechanism for pulmonary injury. (1981) (10)
- Rebound elevation of fibronectin after tissue injury and ischemia: role of fibronectin synthesis. (1992) (10)
- Vascular clearance and metabolism of lipid by the reticuloendothelial system in dogs. (1971) (10)
- Reticuloendothelial (RE) response to surgery as modified by intravenous administration of plasma cryoprecipitate or cold-insoluble globulin (plasma fibronectin) purified by affinity chromatography. (1980) (10)
- Disturbances in Plasma and Cell Surface Fibronectin: Relationship to Altered Vascular Permeability and Host Defense (1981) (10)
- Comparative Influence of Blood‐borne Nonbacterial Particles and Staphylococcus aureus on Fibronectin, Complement and Immunoglobulin (1982) (9)
- Plasma fibronectin and hepatic Kupffer cell function. (1982) (9)
- Hepatic phagocytic, metabolic, and blood-flow evaluation by dynamic scintigraphy. (1972) (9)
- Liver blood flow and intravascular colloid clearance alterations following partial hepatectomy. (1970) (9)
- Phorbol myristate acetate-treated endothelium stimulates polymorphonuclear leukocyte adhesion and superoxide secretion. (1989) (9)
- Fibronectin deficiency and intestinal transvascular fluid balance during bacteremia. (1982) (9)
- Reduced in vivo plasma fibronectin content of lung matrix during postoperative sepsis. (1996) (8)
- Effect of acute plasma fibronectin depletion on tissue fibronectin levels: analysis by a new fluorescent immunoassay. (1984) (8)
- Serum Calcium and Hepatic Kupffer Cell Phagocytosis 1 (1975) (8)
- Increased recycling of α5β1 integrins by lung endothelial cells in response to tumor necrosis factor (2000) (8)
- Blood-borne fragments of fibronectin after thermal injury. (1991) (8)
- Fibronectin: relevance to phagocytic host response to injury. (1989) (8)
- Factor XIII as a modulator of plasma fibronectin alterations during experimental bacteremia. (1986) (8)
- Fibronectin and the critically ill patient: current status (2004) (8)
- TNF-α-induced matrix Fn disruption and decreased endothelial integrity are independent of Fn proteolysis. (1998) (8)
- Humoral control of colloid clearance by reticuloendothelial system in dogs. (1973) (7)
- TNF-alpha-induced matrix Fn disruption and decreased endothelial integrity are independent of Fn proteolysis. (1998) (7)
- ED1-containing cellular fibronectin release into lung lymph during lung vascular injury with postoperative bacteremia. (1993) (7)
- What Is the Theoretical Basis for the Therapeutic Use of Cryoprecipitates as a Source of Fibronectin? (1985) (7)
- A Radial Immunodiffusion Method for the Measurement of Rat Fibrinogen and Fibrin Degradation Products 1 (1979) (7)
- Generation of Neutrophil Chemotactic Activity by Phorbol Ester‐Stimulated Calf Pulmonary Artery Endothelial Cells (1988) (7)
- Kupffer cell complement receptor clearance function after surgical injury and phagocytosis of immune complexes: effect of changes in plasma fibronectin. (1988) (7)
- Effect of fibronectin-rich human cryoprecipitate on fluid volume requirements in sheep during postoperative sepsis. (1988) (7)
- Cardiac output and regional blood flow following trauma. (1978) (7)
- Effect of bacterial sepsis on gluconeogenic capacity in the rat. (1988) (6)
- Depressed reticuloendothelial clearance of platelets in rats after trauma. (1984) (6)
- Phagocytic and Opsonic Activities of Germfree Rats.∗ (1967) (6)
- Measurement of liver blood flow in the infant monkey. A comparison of methods. (1973) (6)
- Hepatic reticuloendothelial host defense failure following surgical trauma. (1975) (6)
- Bacillus Calmette-Guerin induced macrophage stimulation: humoral aspects. (1976) (6)
- Plasma fibronectin levels during cardiopulmonary bypass. (1990) (6)
- Humoral regulation of plasma opsonic fibronectin levels: its role in reticuloendothelial recovery after RE blockade. (1981) (5)
- α-2-Glycoprotein Opsonic Deficiency after Trauma 1 (1977) (5)
- Response of the Opsonic and Phagocytic System to Trauma in Adrenalectomized Animals 1 (1973) (5)
- Cathepsin clearance from the circulation and reticuloendothelial function. (1977) (5)
- Phagocytic and Bactericidal Activities of Pulmonary Macrophages following Sublethal Traumatic Shock 1 (1976) (5)
- Comparative Evaluation of the Influence of Opsonins on Hepatic, Splenic and Pulmonary Phagocytosis.∗ (1967) (5)
- An academic career in a basic medical science department of physiology. (1981) (4)
- Liver parenchymal and Kupffer cell metabolism of 14 C-labeled acetate, palmitate, and triglyceride. (1971) (4)
- Lung fluid and protein flux during postoperative sepsis. (1985) (4)
- [16] Opsonic activity of fibronectin (1986) (4)
- A temporal comparison of post-burn rebound hyperopsonaemia with endocrine parameters (1979) (4)
- Amplification of the opsonic activity of fibronectin by a plasma factor lacking gelatin affinity. (1983) (4)
- Opsonin levels in reticuloendothelial regulation during and following pregnancy. (1973) (4)
- Leukocyte Level as a Potential Factor Determining Hepatic Phagocytosis Following Surgery 1 (1972) (4)
- Contribution of hepatic fibronectin synthesis to regulation of plasma fibronectin. (1989) (4)
- Fibronectin and Reticuloendothelial Clearance of Blood-Borne Particles Clinical Studies in Septic Shock (1985) (4)
- Macrophage metabolism of fibrin: Role of fibronectin (1984) (4)
- Delayed elevation of ED1-cellular fibronectin in plasma following postsurgical bacteremia. (1994) (3)
- Leukocyte elastase-independent proteolysis of gelatin-bound fibronectin by inflammatory macrophages (1991) (3)
- Pulmonary and peripheral lymph protein clearance during bacteremia after surgery. (1988) (3)
- Opsonic glycoprotein (plasma fibronectin) levels after bum injury: Relationship to extent of burns and development of sepsis (1981) (3)
- Enhancement of reticuloendothelial activity by low-dose heparin during intravascular coagulation. (1981) (3)
- Lung matrix deposition of normal and alkylated plasma fibronectin: response to postsurgical sepsis. (1998) (3)
- Hepatic fibronectin matrix turnover in rats: involvement of the asialoglycoprotein receptor. (1999) (3)
- Fibronectin: a mediator of phagocytosis and its potential in treating septic shock. (1982) (2)
- Degradation of Particulate Lipid by the Large-Granule Fraction of Rat Liver (1975) (2)
- Hepatic Vascular Response Following Colloid Injection 1 (1972) (2)
- Effect of bilateral nephrectomy on plasma fibronectin levels: its influence on acute fibronectin response to trauma and RE blockade. (1982) (2)
- Immunoreactive serum opsonic alpha 2 sb glycoprotein as a noninvasive index of RES systemic defense after trauma. (1979) (2)
- Plasma fibronectin and lung vascular injury. (1989) (2)
- Bioassay of serum opsonin and its depletion after colloid clearance in dogs. (1972) (2)
- Alterations of fibronectin and reticuloendothelial phagocytic function during adaptation to experimental shock. (1983) (2)
- A calorimetric analysis of human plasma fibronectin: effects of heparin binding on domain structure. (1988) (2)
- Comparative effect of circulating bacterial or nonbacterial particulates on plasma fibronectin: relationship to lung deposition of blood-borne foreign particles. (1986) (2)
- Reversal of plasma fibronectin deficiency in septic-injured patients by cryoprecipitate infusion. (1982) (2)
- Opsonic fibronectin is necessary for optimal serum-mediated phagocytosis of Staphylococcus aureus by human neutrophils. (1982) (1)
- Elevation of Plasma Lysosomal Enzyme Levels after Trauma in Association with Impairment of Hepatic Reticuloendothelial Function (1976) (1)
- Effect of storage time on the opsonic activity of fibronectin in plasma cryoprecipitate (1986) (1)
- Reticuloendothelial systemic clearance capacity during neonatal development. (1979) (1)
- Plasma Fibronectin: Biochemical Properties and Clinical Relevance (1982) (1)
- Effect of splenectomy on the cardiovascular response to hemorrhage in dogs with immunoreactive opsonic deficiency and reticuloendothelial blockade. (1980) (1)
- Fibronectin and the Reticuloendothelial System: Relationship to Lung Vascular Failure During Septic Shock (1993) (1)
- Current knowledge on fibronectin (1983) (1)
- Lung matrix deposition of normal and alkylated plasma fibronectin: response to postsurgical sepsis. (1998) (1)
- Human plasma fibronectin effect on serum-mediated uptake of Pseudomonas aeruginosa PA 1348A by human granulocytes. (1985) (1)
- Reversing multiple organ failure. (1979) (1)
- Influence of septic peritonitis on circulating fibronectin, immunoglobulin, and complement: relationship to reticuloendothelial phagocytic function. (1983) (1)
- Matrix fibronectin disruption and altered endothelial cell adhesion induced by activated leukocytes (1986) (0)
- KINETICS AND TISSUE INCORPORATION OF PLASMA FIBRONECTIN IN POST‐OPERATIVE SEPTIC RATS.: 190 (1995) (0)
- Immuno reactive and bioassayable opsonic glyco protein plasma fibronectin in burn patients (1980) (0)
- Defective Reticuloendothelial Clearance of Platelets after Whole Body Trauma (1977) (0)
- Opsonic activity of fibronectin. (1986) (0)
- Kupffer cell clearance function following intravenous tumor cell challlenge. (1977) (0)
- The effect of intravenous particles and staphylococcus aureus on serum opsonins. (1982) (0)
- Effect of plasma fibronectin (opsonin) deficiency on pulmonary microvascular permeability during pseudomonas septicemia (1979) (0)
- Disturbances in Fibronectin after Trauma: Relationship to Altered Reticuloendothelial Function Mechanisms, (1983) (0)
- Regional Blood Flow following Traumatic Shock (1976) (0)
- A model for R.E.S. blood clearance involving Michaelis-Menten kinetics. (1973) (0)
- ORGAN FUNCTION IN SEPTIC AND NON-SEPTIC PATIENTS (1982) (0)
- Alpha-2-Glycoprotein opsonic deficiency after trauma (39865). (1977) (0)
- Fibronectin deficiency following cardiopulmonary bypass. (1987) (0)
- Reticuloendothelial function following infusion of bacterial and non-bacterial particulates: relation to plasma fibronectin. (1986) (0)
- Comparative evaluation of pulmonary and peripheral protein clearance following post-operative gram-negative bacteremia. (1988) (0)
- Opsonization and nonspecific promoters of phagocytosis (1986) (0)
- Development of humoral and cellular aspects of macrophage function in fostered and nonfostered neonates. (1973) (0)
- Issue Information (1984) (0)
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