Tadaomi Takenawa
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Biology
Tadaomi Takenawa's Degrees
- PhD Biochemistry University of Tokyo
- Masters Molecular Biology University of Tokyo
- Bachelors Biology University of Tokyo
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(Suggest an Edit or Addition)Tadaomi Takenawa's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly (1999) (1379)
- The WASP–WAVE protein network: connecting the membrane to the cytoskeleton (2007) (949)
- WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac (1998) (751)
- N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases. (1996) (699)
- Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP (1998) (687)
- WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. (2001) (635)
- Regulation of cancer cell motility through actin reorganization (2005) (631)
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling (2000) (592)
- ATP-dependent inositide phosphorylation required for Ca2+-activated secretion (1995) (508)
- Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. (2001) (475)
- Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin (2005) (395)
- Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis (2007) (390)
- C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. (1994) (374)
- Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis (2006) (368)
- Molecular mechanisms of invadopodium formation (2005) (357)
- Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. (2003) (336)
- WIP regulates N-WASP-mediated actin polymerization and filopodium formation (2001) (287)
- Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. (2001) (284)
- Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function (1992) (267)
- WAVE2 is required for directed cell migration and cardiovascular development (2003) (263)
- Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. (1999) (256)
- Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs* (2004) (247)
- PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia (2004) (246)
- Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. (2002) (241)
- The essential role of profilin in the assembly of actin for microspike formation (1998) (241)
- CRMP-2 Is Involved in Kinesin-1-Dependent Transport of the Sra-1/WAVE1 Complex and Axon Formation (2005) (238)
- A Novel Serum Metabolomics-Based Diagnostic Approach for Colorectal Cancer (2012) (228)
- Positive regulation of mu-calpain action by polyphosphoinositides. (1992) (223)
- Sequential signals toward podosome formation in NIH-src cells (2008) (220)
- Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction (2001) (200)
- Regulation of actin dynamics by WASP family proteins. (2003) (195)
- alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. (1994) (193)
- Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function* (2004) (188)
- Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. (2009) (187)
- Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP3, and Rac (2006) (184)
- Sustained activation of N-WASP through phosphorylation is essential for neurite extension. (2002) (182)
- Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments (1997) (176)
- Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. (1996) (176)
- Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins. (2014) (176)
- The RAC Binding Domain/IRSp53-MIM Homology Domain of IRSp53 Induces RAC-dependent Membrane Deformation* (2006) (173)
- A metabolomic approach to lung cancer. (2011) (172)
- Phosphoinositides Regulate Clathrin-Dependent Endocytosis at the Tip of Pollen Tubes in Arabidopsis and Tobacco[W] (2010) (172)
- Core Protein Machinery for Mammalian Phosphatidylinositol 3,5-Bisphosphate Synthesis and Turnover That Regulates the Progression of Endosomal Transport (2007) (169)
- Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. (2007) (169)
- Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. (1992) (164)
- A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique (2009) (162)
- Arp2/3 Activity Is Necessary for Efficient Formation of E-cadherin Adhesive Contacts* (2004) (156)
- A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42 (2001) (153)
- Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells (2005) (149)
- Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm (2003) (149)
- Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization. (1998) (149)
- Myotubularin Regulates the Function of the Late Endosome through the GRAM Domain-Phosphatidylinositol 3,5-Bisphosphate Interaction* (2004) (143)
- Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. (1992) (142)
- Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling. (2002) (140)
- Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils. (1986) (140)
- Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation. (1995) (139)
- Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion (2006) (138)
- A Novel Serum Metabolomics-Based Diagnostic Approach to Pancreatic Cancer (2013) (136)
- IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena (2003) (133)
- Profilin Enhances Cdc42-Induced Nucleation of Actin Polymerization (2000) (132)
- Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. (2003) (131)
- Identification of a Phosphatidylinositol 4,5-Bisphosphate-binding Site in Chicken Skeletal Muscle α-Actinin (*) (1996) (131)
- IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness (2004) (130)
- The WASP and WAVE family proteins (2009) (129)
- Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure (2003) (129)
- A New Phospholipase C 4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus (*) (1996) (126)
- Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2. (1988) (123)
- Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. (1994) (122)
- Purification of phosphatidylinositol-specific phospholipase C from rat liver. (1981) (122)
- Small GTPase Rah/Rab34 Is Associated with Membrane Ruffles and Macropinosomes and Promotes Macropinosome Formation* (2003) (120)
- A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. (1989) (120)
- Serum metabolomics as a novel diagnostic approach for pancreatic cancer (2010) (120)
- Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth (2003) (118)
- Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation (2015) (113)
- Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. (2012) (112)
- Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. (1994) (112)
- Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation (1988) (111)
- Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. (1991) (109)
- N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. (2001) (109)
- The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010) (108)
- GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis (2011) (107)
- Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1. (1998) (105)
- Cloning of a Novel Human Diacylglycerol Kinase (DGKθ) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain* (1997) (103)
- Sperm Factor Induces Intracellular Free Calcium Oscillations by Stimulating the Phosphoinositide Pathway1 (2001) (103)
- Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. (1994) (103)
- Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C. (1989) (102)
- SKIP Negatively Regulates Insulin-Induced GLUT4 Translocation and Membrane Ruffle Formation (2003) (101)
- Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. (2000) (99)
- Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. (1988) (98)
- The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration (2009) (96)
- Identification and Characterization of a Novel Inositol Polyphosphate 5-Phosphatase* (2000) (95)
- Ash/Grb‐2, a SH2/SH3‐containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. (1993) (95)
- Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone (2003) (94)
- Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunit. (1994) (92)
- Modulation of GABAA Receptor Phosphorylation and Membrane Trafficking by Phospholipase C-related Inactive Protein/Protein Phosphatase 1 and 2A Signaling Complex Underlying Brain-derived Neurotrophic Factor-dependent Regulation of GABAergic Inhibition* (2006) (91)
- Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. (2004) (91)
- Essential Role of Neural Wiskott-Aldrich Syndrome Protein in Neurite Extension in PC12 Cells and Rat Hippocampal Primary Culture Cells* (2000) (89)
- Phospholipase Cδ1 is required for skin stem cell lineage commitment (2003) (89)
- WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor (2005) (88)
- Nebulin and N-WASP Cooperate to Cause IGF-1–Induced Sarcomeric Actin Filament Formation (2010) (88)
- Phosphatidylinositol 4-Phosphate 5-Kinase Type I Is Regulated through Phosphorylation Response by Extracellular Stimuli* (2001) (87)
- Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. (1992) (87)
- Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts. (1988) (87)
- SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain (2011) (85)
- A Novel Phosphatidylinositol-5-phosphate 4-Kinase (Phosphatidylinositol-phosphate Kinase IIγ) Is Phosphorylated in the Endoplasmic Reticulum in Response to Mitogenic Signals* (1998) (83)
- Phosholipase C-Related Inactive Protein Is Involved in Trafficking of γ2 Subunit-Containing GABAA Receptors to the Cell Surface (2007) (83)
- WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. (2002) (83)
- Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. (1991) (83)
- Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins* (1996) (81)
- WASP and WAVE family proteins: Friends or foes in cancer invasion? (2010) (80)
- Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography–mass spectrometry (2011) (80)
- A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (1997) (79)
- Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain. (1988) (79)
- WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (2002) (78)
- Role of Phosphatidylinositol 4,5-Bisphosphate in Ras/Rac-Induced Disruption of the Cortactin-Actomyosin II Complex and Malignant Transformation (1998) (77)
- Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils. (1983) (77)
- N-WASP and WAVE2 Acting Downstream of Phosphatidylinositol 3-Kinase Are Required for Myogenic Cell Migration Induced by Hepatocyte Growth Factor* (2004) (75)
- Neural Wiskott–Aldrich syndrome protein (N‐WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin‐based spreading (2002) (75)
- CDP-diglyceride:inositol transferase from rat liver. Purification and properties. (1977) (73)
- DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras–ERK pathway, is required for myogenic differentiation (2007) (71)
- Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins. (2002) (70)
- Regulation of cortical actin networks in cell migration. (2003) (69)
- Aberrant accumulation of phospholipase C-delta in Alzheimer brains. (1991) (68)
- Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells. (1994) (68)
- A complex of GRB2‐dynamin binds to tyrosine‐phosphorylated insulin receptor substrate‐1 after insulin treatment. (1994) (68)
- Identification and Characterization of a Sac Domain-containing Phosphoinositide 5-Phosphatase* (2001) (67)
- Meltrin α cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src (2000) (65)
- Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. (2007) (63)
- Neural Wiskott-Aldrich Syndrome Protein Is Recruited to Rafts and Associates with Endophilin A in Response to Epidermal Growth Factor* (2003) (63)
- Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. (2014) (62)
- Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats. (1992) (62)
- Translocation of N-WASP by Nuclear Localization and Export Signals into the Nucleus Modulates Expression of HSP90* (2003) (61)
- Rho Family Gtpase Cdc42 Is Essential for the Actin-Based Motility of Shigella in Mammalian Cells (2000) (60)
- Phosphorylation of WAVE Downstream of Mitogen-activated Protein Kinase Signaling* (1999) (60)
- WAVE/Scars in platelets. (2005) (60)
- Phospholipase C-δ1 and -δ3 Are Essential in the Trophoblast for Placental Development (2005) (60)
- Solubilization of the enzyme catalyzing CDP-diglyceride-independent incorporation of myo-inositol into phosphatidyl inositol and its comparison to CDP-diglyceride:inositol transferase. (1977) (59)
- The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. (1993) (59)
- Phospholipase C-gamma 1 associates with viral and cellular src kinases. (1993) (58)
- Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin. (1992) (58)
- Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo. (1992) (58)
- Influence of age on the signal transduction of T cells in mice. (1993) (58)
- Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region. (1992) (58)
- Novel Inositol Polyphosphate 5-Phosphatase Localizes at Membrane Ruffles* (1999) (58)
- Involvement of the nectin-afadin complex in PDGF-induced cell survival (2008) (57)
- Identification of N-WASP homologs in human and rat brain. (1997) (56)
- Evidence for involvement of phospholipase C-gamma 2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells. (1993) (55)
- Interaction of HSP90 to N‐WASP leads to activation and protection from proteasome‐dependent degradation (2005) (55)
- Characterization of G Family G Proteins G (G), G (G), and G Expressed in the Baculovirus-Insect Cell System (*) (1995) (54)
- Visualization and force measurement of branching by Arp2/3 complex and N-WASP in actin filament. (2002) (53)
- Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation. (1997) (52)
- Increased Insulin Action in SKIP Heterozygous Knockout Mice (2008) (52)
- SGIP1α Is an Endocytic Protein That Directly Interacts with Phospholipids and Eps15* (2007) (51)
- Cellular distribution of polyphosphoinositides in rat hepatocytes. (1993) (51)
- A Novel Phospholipase C δ4 (PLCδ4) Splice Variant as a Negative Regulator of PLC* (1999) (51)
- Lentysine: a new hypolipidemic agent from a mushroom. (1970) (51)
- Identification of Another Actin-related Protein (Arp) 2/3 Complex Binding Site in Neural Wiskott-Aldrich Syndrome Protein (N-WASP) That Complements Actin Polymerization Induced by the Arp2/3 Complex Activating (VCA) Domain of N-WASP* (2001) (51)
- Identification and Characterization of a New Phospholipase C-like Protein, PLC-L2 (1999) (51)
- Phospholipase C‐δ1 is an essential molecule downstream of Foxnl, the gene responsible for the nude mutation, in normal hair development (2008) (51)
- The effects of retinoids on proliferative capacities and macromolecular synthesis in human breast cancer MCF‐7 cells (1980) (49)
- A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading (2005) (49)
- Autophosphorylation of Type I Phosphatidylinositol Phosphate Kinase Regulates Its Lipid Kinase Activity* (2000) (49)
- Profilin Is Required for Sustaining Efficient Intra- and Intercellular Spreading of Shigella flexneri * (2000) (49)
- Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis (1999) (49)
- Phospholipase C-related but Catalytically Inactive Protein Is Required for Insulin-induced Cell Surface Expression of γ-Aminobutyric Acid Type A Receptors* (2009) (49)
- Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors. (1991) (48)
- The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. (2007) (48)
- Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion* (2013) (48)
- Phospholipase Cdelta1 is required for skin stem cell lineage commitment. (2003) (47)
- Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae. (1989) (47)
- Regulation of Insulin Signaling and Glucose Transporter 4 (GLUT4) Exocytosis by Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) Phosphatase, Skeletal Muscle, and Kidney Enriched Inositol Polyphosphate Phosphatase (SKIP) (2012) (47)
- Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2. (2001) (46)
- Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. (2006) (46)
- Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain. (1990) (46)
- Phosphatidylinositol 3-Kinase Is a Key Regulator of Early Phase Differentiation in Keratinocytes* (2002) (46)
- Purification and characterization of nuclear phospholipase C specific for phosphoinositides. (1994) (45)
- The mechanism of macrophage activation induced by Ca2+ ionophore. (1983) (45)
- WASP and N-WASP in human platelets differ in sensitivity to protease calpain. (2001) (45)
- The Rat Homologue of Wiskott-Aldrich Syndrome Protein (WASP)-interacting Protein (WIP) Associates with Actin Filaments, Recruits N-WASP from the Nucleus, and Mediates Mobilization of Actin from Stress Fibers in Favor of Filopodia Formation* (2002) (44)
- Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs. (2004) (44)
- Role of Phospholipase C-L2, a Novel Phospholipase C-Like Protein That Lacks Lipase Activity, in B-Cell Receptor Signaling (2003) (44)
- Mechanisms of membrane deformation by lipid-binding domains. (2009) (44)
- Crystal structure of human DAAM1 formin homology 2 domain (2007) (43)
- Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase (2009) (43)
- Ca2+-dependent and Ca2+-independent degradation of phosphatidylinositol in rabbit vas deferens. (1981) (43)
- Phospholipase C δ-type consists of three isozymes: bovine PLCδ2 is a homologue of human/mouse PLCδ4 (2004) (43)
- Inhibition of inositol phospholipids metabolism and calcium mobilization by cyclic AMP-increasing agents and phorbol ester in neutrophils. (1986) (42)
- Membrane targeting and remodeling through phosphoinositide‐binding domains (2006) (42)
- RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C (2012) (42)
- Serum fatty acid profiling of colorectal cancer by gas chromatography/mass spectrometry. (2011) (41)
- Wiskott-Aldrich Syndrome Protein Induces Actin Clustering without Direct Binding to Cdc42* (1999) (41)
- Isolation of a cDNA Encoding Human Lysophosphatidic Acid Phosphatase That Is Involved in the Regulation of Mitochondrial Lipid Biosynthesis* (1999) (41)
- Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation. (1987) (40)
- Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils. (1987) (40)
- α-Actinin-4 Enhances Colorectal Cancer Cell Invasion by Suppressing Focal Adhesion Maturation (2015) (40)
- Isolation and characterization of a gamma-type phosphoinositide-specific phospholipase C (PLC-gamma 2). (1990) (39)
- Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. (2003) (39)
- Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins. (2004) (38)
- Phosphorylation of phospholipase Cgamma1 on tyrosine residue 783 by platelet-derived growth factor regulates reorganization of the cytoskeleton. (1998) (37)
- Pharbin, a novel inositol polyphosphate 5-phosphatase, induces dendritic appearances in fibroblasts. (1999) (37)
- Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain. (1988) (37)
- The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration (2012) (36)
- Protein kinase A‐dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin (2006) (35)
- Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells. (2002) (35)
- Quantitative changes in polyphosphoinositides 1,2-diacylglycerol and inositol 1,4,5-trisphosphate by platelet-derived growth factor and prostaglandin F2 alpha. (1989) (35)
- The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton. (1999) (35)
- Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels. (2006) (33)
- Involvement of Phospholipase C-Related Inactive Protein in the Mouse Reproductive System Through the Regulation of Gonadotropin Levels1 (2009) (32)
- Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation (2001) (32)
- Proteome of Acidic Phospholipid-binding Proteins (2009) (32)
- Molecular cloning of bovine actin-like protein, actin2. (1992) (32)
- Differential activation of phospholipids metabolism by formylated peptide and ionophore A23187 in guinea pig peritoneal macrophages. (1982) (32)
- Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1 (2012) (31)
- Role of enhanced inositol phospholipid metabolism in neutrophil activation. (1985) (31)
- Effect of unsaturated fatty acids and Ca2+ on phosphatidylinositol synthesis and breakdown. (1982) (31)
- srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity (2013) (30)
- Male‐specific sterility caused by the loss of CR16 (2007) (30)
- Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase. (1991) (30)
- WAVE3 functions as a negative regulator of LDOC1. (2005) (29)
- WICH, a member of WASP-interacting protein family, cross-links actin filaments. (2005) (29)
- Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site. (1991) (29)
- Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides. (2006) (29)
- Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation (2013) (28)
- HSP90 cross‐links branched actin filaments induced by N‐WASP and the Arp2/3 complex (2007) (28)
- Disappearance of diacylglycerol kinase translocation in ras-transformed cells. (1988) (28)
- Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation. (1999) (27)
- Requirement of the basic region of N-WASP/WAVE2 for actin-based motility. (2001) (27)
- Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy (2015) (27)
- Development expression of the neural adhesion molecule F3 in the rat brain (1995) (26)
- Purification and characterization of a cytosolic phosphoinositide-phospholipase C (gamma 2-type) from human platelets. (1990) (26)
- Purification and characterization of a lysophosphatidic acid-specific phosphatase. (1998) (26)
- Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha. (1994) (26)
- PtdIns(3,4)P2 instigates focal adhesions to generate podosomes (2009) (26)
- ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5 (2012) (26)
- PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA‐MB‐231 breast cancer cells (2017) (25)
- Isolation of the active form of RAC‐protein kinase (PKB/Akt) from transfected COS‐7 cells treated with heat shock stress and effects of phosphatidylinositol 3,4,5‐trisphosphate and phosphatidylinositol 4,5‐bisphosphate on its enzyme activity (1996) (24)
- Characterization of the EFC/F‐BAR domain protein, FCHO2 (2011) (24)
- Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase (2006) (24)
- Phosphatidyl inositol: myo-inositol exchange enzyme from rat liver: partial purification and characterization. (1980) (24)
- Phosphoinositide-binding interface proteins involved in shaping cell membranes (2010) (24)
- Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (1999) (23)
- Arp2/3 complex-independent actin regulatory function of WAVE. (2000) (23)
- Different interactions of Grb2/Ash molecule with the NGF and EGF receptors in rat pheochromocytoma PC12 cells. (1994) (23)
- Abnormal accumulation of phospholipase C-δ in filamentous inclusions of human neurodegenerative diseases (1993) (23)
- Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. (2005) (23)
- Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system. (1995) (22)
- Potentiation of PGE1-induced increase in cyclic AMP by chemotactic peptide and Ca2+ ionophore through calmodulin-dependent processes. (1987) (22)
- Signaling through Grb2/Ash-control of the Ras pathway and cytoskeleton. (1998) (22)
- Possible involvement of Wiskott–Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease (2003) (22)
- Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1. (2013) (22)
- Effect of calmodulin antagonists on lysosomal enzyme secretion and phospholipid metabolism in guinea-pig macrophages. (1982) (21)
- FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. (2004) (20)
- Two verprolin homology domains increase the Arp2/3 complex-mediated actin polymerization activities of N-WASP and WAVE1 C-terminal regions. (2002) (20)
- Purification of two distinct types of phosphoinositide-specific phospholipase C from rat liver. Enzymological and structural studies. (1988) (20)
- Epidermal growth factor stimulates diacylglycerol kinase in isolated plasma membrane vesicles from A431 cells. (1985) (19)
- Growth factor‐induced promoter activation of murine phospholipase C δ4 gene (2000) (19)
- Properties of phospholipase C isozymes. (1991) (19)
- Phospholipase C delta-type consists of three isozymes: bovine PLCdelta2 is a homologue of human/mouse PLCdelta4. (2004) (18)
- Actin-related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats (2007) (18)
- Characterization of the association of phospholipase C-δ with Alzheimer neurofibrillary tangles (1995) (18)
- Mutation of ARHGAP9 in patients with coronary spastic angina (2010) (18)
- Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases. (1993) (16)
- Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65. (1996) (16)
- Reorganization of membrane cholesterol during membrane fusion in myogenesis in vitro: a study using the filipin-cholesterol complex. (1984) (16)
- IRSp53 Mediates Podosome Formation via VASP in NIH-Src Cells (2013) (16)
- Kinetic properties of Ash/Grb2-interacting GDP/GTP exchange protein. (1994) (15)
- Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling (2003) (15)
- Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes[S] (2012) (15)
- Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin. (2011) (15)
- A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC. (1999) (15)
- Phospholipase C activation and diacylglycerol kinase inactivation lead to an increase in diacylglycerol content in spontaneously hypertensive rat. (1987) (15)
- Retinoic acid-binding protein in a human cell (MCF-7) from breast carcinoma. (1980) (15)
- GABAA receptor subunit alteration‐dependent diazepam insensitivity in the cerebellum of phospholipase C‐related inactive protein knockout mice (2010) (14)
- Increase in norepinephrine-induced formation of phosphatidic acid in rat vas deferens after denervation. (1983) (14)
- Altered Signal Transduction in erbB-transformed Cells (1987) (14)
- Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. (1991) (14)
- Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78. (2015) (13)
- A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts. (2003) (13)
- Cloning of the cDNA encoding neural adhesion molecule F3 from bovine brain. (1995) (13)
- Inositol phospholipids in stimulated smooth muscles. (1982) (13)
- From N-WASP to WAVE: key molecules for regulation of cortical actin organization. (2005) (12)
- Increased formation of phosphatidic acid induced with vasopressin or Ca2+ ionophore A23187 in rat hepatocytes. (1982) (12)
- Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro. (1998) (12)
- Thin layer chromatography-blotting, a novel method for the detection of phosphoinositides. (2006) (12)
- Defect in phorbol acetate‐induced translocation of diacylglycerol kinase in erbB‐transformed fibroblast cells (1989) (12)
- GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients. (2014) (11)
- Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance (2015) (11)
- Evidence for differential activation of arachidonic acid metabolism in formylpeptide- and macrophage-activation-factor-stimulated guinea-pig macrophages. (1985) (11)
- Isolation and characterization of temperature-sensitiveplc1 mutants of the yeastSaccharomyces cerevisiae (1995) (10)
- Developmental expression of neural Wiskott–Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus (2006) (10)
- Disruption of Phospholipase Cδ4 Gene Modulates the Liver Regeneration in Cooperation with Nuclear Protein Kinase C (2006) (10)
- Role of Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) 5-Phosphatase Skeletal Muscle- and Kidney-enriched Inositol Polyphosphate Phosphatase (SKIP) in Myoblast Differentiation* (2012) (10)
- An inhibitor of inositol-phospholipid-specific phospholipase C. (1993) (9)
- IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues (2015) (9)
- Phospholipase Cδ4: From genome structure to physiological function (2003) (9)
- Aberrant Phosphoinositide Metabolism in Alzheimer's Disease a (1993) (9)
- Involvement of PRIP, Phospholipase C-related, but Catalytically Inactive Protein, in Bone Formation* (2011) (9)
- Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4‐phosphate in breast cancer (2016) (8)
- Potentiation of GTP of hormone-responsive adenylate cyclase in renal cortex plasma membrane preparations. (1978) (8)
- Glucose‐regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization (2016) (8)
- Purification of recombinant SH2SH3 proteins of phospholipase C-γ1 and -γ2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-γ (1992) (8)
- Function of Phospholipids (1988) (7)
- Requirement of phosphatidylinositol 4,5-biphosphate for α-actinin function (1992) (7)
- [Acutely-induced dietary hypercholisterolemia in the rat]. (1972) (6)
- Tissue-specific effects of divalent cations and activators on soluble guanylate cyclase. (1979) (6)
- Focus on Fertilization Evidence that activation of Src family kinase is not required for fertilization-associated [Ca 2 1 ] i oscillations in mouse eggs (2004) (6)
- Growth factor-induced promoter activation of murine phospholipase C delta4 gene. (2000) (6)
- Adenovirus E1A proteins stimulate inositol phospholipid metabolism in PC12 cells (1992) (6)
- Isolation and characterization of rat 3Y1 fibroblast clones overexpressing the src homology region of phospholipase C-gamma 2. (1992) (5)
- Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C. (2006) (5)
- Phospholipase Cdelta4: from genome structure to physiological function. (2003) (5)
- Isolation and characterization of temperature-sensitive plc1 mutants of the yeast Saccharomyces cerevisiae. (1995) (4)
- Potentiation of thyrotropin releasing hormone-induced inositol phospholipid metabolism and Ca2+ mobilization by cyclic AMP-increasing agents. (1987) (4)
- Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain. (2015) (4)
- Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates (2009) (4)
- Effect of transforming growth factor‐α on inositol phospholipid metabolism in human epidermoid carcinoma cells (1988) (4)
- [Hypocholesterolemic activity of analogous compounds related to eritadenine, an active component of shiitake, Lentinus edodes Sing (author's transl)]. (1974) (3)
- Phosphoinositide metabolism and oncogenes. (1989) (3)
- Stress-associated MAP kinase fills in the map of filamin-mediated neuronal migration. (2007) (3)
- Interaction of Ash / Grb2 via its SH 3 domains with neuron-specific p 150 and p 65 (1996) (3)
- Activation of phosphatidic acid metabolism of human erythrocyte membranes by perfringolysin O. (1986) (3)
- Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans. (2007) (3)
- Regulation of hormone(PTH and PGE1)-stimulated adenylate cyclase by renal cytosolic factors (1981) (3)
- [WASP-family, a critical signal transducer linking various signals to rapid actin-polymerization]. (2000) (2)
- TRP-PLIK , a Bifunctional Protein with Kinase and Ion Channel Activities (2)
- [Studies on the multi-stage reactor of gas-liquid counter-flow type. II. Auto-oxidation of D-glucose in liquid phase in the presence of Pd-BaSO catalyst]. (1967) (2)
- Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. (2006) (2)
- [Receptor activation and inositol phospholipids]. (1985) (2)
- Neural Wiskott-Aldrich syndrome protein is required for accurate chromosome congression and segregation (2011) (2)
- Crystal structure of RCB domain of IRSp53 (2005) (1)
- [Hormone receptor and stimulated turnover of inositol phospholipids; role of PI response in the enhancement of Ca2+ influx]. (1982) (1)
- Purification of recombinant SH2/SH3 proteins of phospholipase C-gamma 1 and -gamma 2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-gamma. (1992) (1)
- Signal transductions of SH2/SH3: Ash/Grb-2 downstream signaling. (1996) (1)
- Harumi Glucose-induced Insulin Secretion Determines the Biphasic Response of Protein ( N-WASP ) and Cofilin Activities of Neuronal Wiskott-Aldrich Syndrome Actin Dynamics Regulated by the Balance Signal Transduction : (2013) (1)
- A positi v e role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts (2003) (1)
- spreading machinery development and spreading: implications for platelet biogenesis and The WAVE2/Abi1 complex differentially regulates megakaryocyte (2013) (0)
- Inhibitory Effect of Prostaglandin Ea, Forskolin, and Dibutyryl cAMP on Arachidonic Acid Release and Inositol Phospholipid Metabolism in (1986) (0)
- Phosphatidylinositol kinase and cell transformation. (1990) (0)
- Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain. (1992) (0)
- [Role of inositol phospholipids metabolism in the signal transduction of erbB gene product]. (1986) (0)
- Molecular and Cellular Pathobiology Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell – Cell Adhesion and Invasive Cell Migration in Human Breast Cancer (2014) (0)
- Gene Therapy Gene Therapy for Wiskott Aldrich Syndrome-Rescue of T-Cell Signaling and Amelioration of Colitis upon Transplantation of Retrovirally Transduced Hematopoietic Stem Cells in Mice (2002) (0)
- Kobe University Repository : Kernel タイトル Tit le Serum metabolomics as a novel diagnost ic approach for pancreat ic cancer (2018) (0)
- Platelet-derived growth factor activates protein kinase CG through redundant and independent signaling pathways involving phospholipase Cy or phosphatidylinositol 3-kinase (signal (2005) (0)
- Molecular mechanism of actin cytoskeleton rearrangement promoting lamellipodia and filopodia formation. (2000) (0)
- Differential functions of WAVE1 and 2 in cell migration and spreading. (2004) (0)
- Kobe University Repository : Kernel タイトル Tit le Mechanisms of membrane deformat ion by lipid-binding domains 著者 (2019) (0)
- Receptor activation and inositol phospholipids metabolism. (1987) (0)
- Phosphatidylinositol 4-kinase from bovine brain (1993) (0)
- Kobe University Repository : Kernel タイトル Tit le The WASP and WAVE family proteins 著者 (2018) (0)
- HYPOCHOLESTEROLEMIC ACTIVITY OF ANALOGOUS COMPOUNDS RELATED TO ERITADENINE, AN ACTIVE COMPOUND OF SHIITAKE, LENTINUS EDODES SING (1974) (0)
- Role of profilin in actin cytosketal reorganization (1998) (0)
- Role of WASp Family Proteins in Cytoskeletal Reorganization and Cell Motility (2004) (0)
- Immunological detection of phosphatidylinositol 4,5 bisphosphate (PIP2) in human red blood cells (RBC) and in rat liver (1990) (0)
- Inhibition of microtubule assembly in vitro by a synthetic antitumor drug, TN-16. (1983) (0)
- 1SP6-02 Structure, function and regulation of the EFC/F-BAR domain proteins(1SP6 Membrane transformers!! : The combine and the dissociation to change the shape of biomembrane,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
- [Phosphoinositide metabolism and signal transduction]. (1990) (0)
- 3P023 Mechanism of membrane tubulation by the EFC/F-BAR domain(Hemeproteins. Electronic states. Proteins-structure and structure-function relationship,Oral Presentations) (2007) (0)
- Coupling Membrane Dynamics to Actin Polymerization (2010) (0)
- Isolation and characterization of a y-type phosphoinositide-specific phospholipase C ( PLC-y 2 ) (2005) (0)
- [Short-term aortic lipidosis in the rat (author's transl)]. (1974) (0)
- High Ca2+-sensitivity and Ca2+ Oscillation-inducing Activity of PLC-zeta (2004) (0)
- Sigualing of cell migration (2003) (0)
- Actin filament reorganization is necessary to facilitate dynamic cellular events. Preface. (2013) (0)
- Control mechanism of arachidonic acid releasing. (1986) (0)
- [Phosphatidylinositol kinase: functional roles for PI4-kinase and PIP kinase in signal transduction]. (1999) (0)
- [Structure and regulation of PI-kinase, PIP-kinase]. (1991) (0)
- Regulation of inositol phospholipid metabolism and arachidonic acid release: inhibitory mechanism of arachidonic acid release by prostaglandin E2 and cAMP. (1985) (0)
- 高Ca2+感受性とCa2+振動誘発PLC‐ゼータの活性 (2004) (0)
- Correction for A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique, by Akikazu Fujita, Jinglei Cheng, Kumi Tauchi-Sato (2009) (0)
- Roles of WAVE isoforms promoting lamellipodia and filopodia extension at neuronal growth cones (2003) (0)
- [Regulation of actin polymerization by Rho family]. (2006) (0)
- [The challenge of disease diagnosis by metabolomics]. (2010) (0)
- [Phosphatidylinositol in signal transduction]. (2007) (0)
- Standardization of Measurement of Nitrogen Concentration in CZ Silicon Crystals (2006) (0)
- Role of Membrane Lipids in the Activation of Hormone Receptor (1981) (0)
- ANovelSerumMetabolomics-BasedDiagnosticApproachto Pancreatic Cancer (2013) (0)
- Interaction of PIP2 and histone H1 reversed the transcription repression by histone H1 (1996) (0)
- The Wiskott-Aldrich syndrome protein verprolin homologous (WAVE) 1 is essential to localize MT1-MMP at the leading edge of migrating cells (2010) (0)
- plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells (2018) (0)
- UCSD MOLECULE PAGES WAVE2 (2013) (0)
- Regulation of cytoskeleton by inositol phospholipids. (1994) (0)
- Function and Specificity of Biomembrane (1974) (0)
- Growth response mediated by increase in intracellular calcium induces the expression of PLCδ4 (1998) (0)
- Reguration of actin cytoskeleton by WASP in a manner independent of direct-binding to Cdc42 (1998) (0)
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