Tadatsugu Taniguchi | Academic Influence

Tadatsugu Taniguchi's AcademicInfluence.com Rankings

Tadatsugu Taniguchi

Biology

#569

World Rank

#1002

Historical Rank

Immunology

#119

World Rank

#126

Historical Rank

biology Degrees

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Biology

Tadatsugu Taniguchi's Degrees

PhD Immunology Kyoto University
Doctorate Medicine Kyoto University

Why Is Tadatsugu Taniguchi Influential?

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According to Wikipedia, Tadatsugu Taniguchi is a Japanese immunologist known for his pioneer research on Interferons and Interferon regulatory factors. Contribution Taniguchi's work is mostly focused on immunity and oncogenesis, in particular on the mechanisms of signal transduction and gene expression. While working at the Cancer Institute in Tokyo, he conducted breakthrough research on sequencing the cDNA, and identified two cytokine genes, interferon-beta and interleukin-2. These advances helped characterize various cytokines and discover a new family of transcription factors, interferon regulatory factors, which play essential roles in the immune system and cancer.

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Tadatsugu Taniguchi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species (2011) (3065)
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. (2002) (2255)
IRF-7 is the master regulator of type-I interferon-dependent immune responses (2005) (2236)
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota (2013) (2172)
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. (2000) (2112)
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin (1986) (2056)
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response (2007) (1643)
IRF family of transcription factors as regulators of host defense. (2001) (1589)
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors (2006) (1566)
A new protein containing an SH2 domain that inhibits JAK kinases (1997) (1497)
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction (1995) (1379)
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction (2000) (1250)
The IRF family transcription factors in immunity and oncogenesis. (2008) (1129)
Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors (2006) (1114)
Structure and expression of a cloned cDNA for human interleukin-2 (1983) (1082)
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors (2005) (1032)
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ (2000) (988)
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. (1988) (943)
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements (1988) (932)
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes (1989) (928)
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction (2005) (918)
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis (2004) (803)
The IL-2 IL-2 receptor system: A current overview (1993) (779)
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. (2000) (772)
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β (2002) (712)
Cytokine signaling through nonreceptor protein tyrosine kinases. (1995) (709)
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development (1993) (644)
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses (2009) (640)
The IL-2 receptor complex: its structure, function, and target genes. (1993) (635)
Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7 (1998) (599)
Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence (2003) (577)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA (2014) (552)
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. (2004) (548)
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection (2004) (536)
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. (2006) (529)
Nucleotide sequence heterogeneity of an RNA phage population (1978) (525)
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1 (1994) (516)
Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association (1991) (508)
A weak signal for strong responses: interferon-alpha/beta revisited (2001) (500)
Induction of interleukin 2 receptor gene expression by p40x encoded by human T‐cell leukemia virus type 1. (1986) (481)
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2 (1993) (476)
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. (2000) (465)
The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors (2002) (458)
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes (1995) (458)
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system (1993) (450)
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. (2003) (441)
Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering (1987) (430)
Negative regulation of Toll-like-receptor signaling by IRF-4. (2005) (416)
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation (1995) (402)
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. (1997) (388)
Regulation of the type I IFN induction: a current view. (2005) (379)
Requirement for IRF-1 in the microenvironment supporting development of natural killer cells (1998) (375)
Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated (1990) (364)
Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection (2003) (360)
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism* (2007) (359)
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage (1996) (352)
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules (2008) (339)
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program (2006) (324)
Integral role of Noxa in p53-mediated apoptotic response. (2003) (321)
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system (1994) (314)
Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1 (1989) (311)
Evidence for a nuclear factor(s), IRF‐1, mediating induction and silencing properties to human IFN‐beta gene regulatory elements. (1988) (309)
Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. (2000) (309)
A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization (1989) (309)
Antiviral response by natural killer cells through TRAIL gene induction by IFN–α/β (2001) (293)
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation (2005) (292)
Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene (1998) (290)
Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. (2003) (289)
Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. (1989) (276)
Regulation of immunity and oncogenesis by the IRF transcription factor family (2010) (272)
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. (2003) (254)
Human leukocyte and fibroblast interferons are structurally related (1980) (251)
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). (1995) (250)
Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies (1996) (247)
IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism1 (2004) (233)
Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes. (1992) (231)
The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. (2002) (227)
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression (2007) (224)
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc (1992) (224)
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. (2003) (223)
CD8 (+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-α/β signaling (2000) (220)
A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes (1996) (217)
Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences (1999) (216)
Regulation of cytokine gene expression. (1988) (216)
Type I Interferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors (DOI:10.1016/j.immuni.2006.08.009) (2006) (209)
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity (2008) (207)
Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes (1986) (206)
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2 (1995) (204)
Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase* (2000) (202)
Gene induction pathways mediated by distinct IRFs during viral infection. (2001) (197)
The nucleotide sequence of human fibroblast interferon cDNA. (1980) (196)
The IRF family of transcription factors (2012) (195)
The IRF family transcription factors at the interface of innate and adaptive immune responses. (2013) (191)
Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. (1991) (191)
Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity (1997) (189)
Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family. (1985) (189)
Unique structure of murine interleukin-2 as deduced from cloned cDNAs (1985) (181)
The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family. (2018) (179)
Type I interferons are essential mediators of apoptotic death in virally infected cells (1998) (176)
Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway. (1995) (173)
Qβ DNA-containing hybrid plasmids giving rise to Qβ phage formation in the bacterial host (1978) (170)
Interplay between interferon and other cytokine systems in bone metabolism (2005) (165)
Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer (1987) (161)
New human gene encoding a positive modulator of HIV Tat-mediated transactivation (1992) (159)
Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene (1985) (159)
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. (1997) (158)
Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection (2013) (156)
The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout mice. (2001) (154)
Signaling crosstalk between RANKL and interferons in osteoclast differentiation (2002) (154)
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells (2008) (148)
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses (2014) (147)
Structure of the human interleukin 2 gene. (1983) (146)
Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma. (1988) (146)
Interferon regulatory factor family of transcription factors and regulation of oncogenesis (2008) (142)
The role of interferon regulatory factors in the interferon system and cell growth control. (1998) (140)
Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses (2012) (138)
High-mobility group box family of proteins: ligand and sensor for innate immunity. (2012) (136)
Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation. (1994) (136)
IRF-1: the transcription factor linking the interferon response and oncogenesis. (1997) (134)
Reconstitution of functional receptor for human interleukin-2 in mouse cells (1985) (130)
Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. (1999) (129)
Protein tyrosine kinase Pyk2 mediates the Jak‐dependent activation of MAPK and Stat1 in IFN‐γ, but not IFN‐α, signaling (1999) (128)
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. (1997) (127)
Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes (2009) (121)
Association of p56lck with IL‐2 receptor beta chain is critical for the IL‐2‐induced activation of p56lck. (1993) (120)
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA (2009) (119)
Activation of the Transcription Factor ISGF3 by Interferon-gamma (1999) (118)
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. (1993) (114)
Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation. (2007) (112)
Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1. (1989) (112)
Structure and expression of a cloned cDNA for mouse interferon-beta. (1983) (112)
Interleukin 2 (IL2) is assigned to human chromosome 4 (1984) (110)
Cross talk of the interferon‐α/β signalling complex with gp130 for effective interleukin‐6 signalling (2001) (106)
Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression. (1996) (102)
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation (2010) (99)
Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β (1996) (98)
PGE2 induced in and released by dying cells functions as an inhibitory DAMP (2016) (98)
Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1. (1994) (96)
Differential contribution of Puma and Noxa in dual regulation of p53‐mediated apoptotic pathways (2006) (95)
Constitutive IFN-a/ Signal for Efficient IFN-a/ Gene Induction by Virus (2001) (95)
Functionally inactivating point mutation in the tumor‐suppressor IRF‐1 gene identified in human gastric cancer (1998) (95)
The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain. (1994) (94)
The enhanced production of placental interleukin-1 during labor and intrauterine infection. (1991) (94)
CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. (2000) (93)
Structure of a chromosomal gene for human interferon beta. (1981) (93)
Negative regulation of IFN-α/β signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells (2004) (90)
Expression of the human fibroblast interferon gene in Escherichia coli. (1980) (89)
Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration. (2000) (89)
Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter (1991) (88)
Cytokine gene regulation: regulatory cis-elements and DNA binding factors involved in the interferon system. (1992) (88)
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus (2010) (88)
Cell Cycle Regulation of Histone H4 Gene Transcription Requires the Oncogenic Factor IRF-2* (1998) (87)
Construction and identification of a bacterial plasmid containing the human fibroblast interferon gene sequence. (1979) (86)
The interferon regulatory factors and oncogenesis. (2000) (86)
Retroviral expression of the human IL‐2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity. (1987) (86)
Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. (1991) (84)
Site-directed mutations in the initiator region of the bacteriophage Qβ coat cistron and their effect on ribosome binding☆ (1978) (84)
Involvement of a cis-element that binds an H2TF-1/NF kappa B like factor(s) in the virus-induced interferon-beta gene expression. (1989) (82)
Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia. (1993) (79)
Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain. (1992) (79)
New aspects of IFN‐α/β signalling in immunity, oncogenesis and bone metabolism (2003) (78)
The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1. (2004) (76)
Interleukin-8 in cord sera: a sensitive and specific marker for the detection of preterm chorioamnionitis. (1992) (75)
Molecular cloning of human interferon cDNA. (1980) (72)
Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. (2016) (72)
The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment (1990) (70)
A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis (2008) (69)
Molecular Analysis of the Interleukin‐2 System (1986) (68)
Functional dissection of the cytoplasmic subregions of the IL‐2 receptor βc chain in primary lymphocyte populations (1998) (68)
Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling (1994) (68)
Wild-Type Measles Virus Infection in Human CD46/CD150-Transgenic Mice: CD11c-Positive Dendritic Cells Establish Systemic Viral Infection1 (2005) (67)
Requirement of the IFN‐α/β‐induced CXCR3 chemokine signalling for CD8+ T cell activation (2002) (67)
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view. (2009) (66)
Organization and structure of the mouse interleukin-2 gene. (1984) (64)
Localization of three subtypes of Fc gamma receptors in human placenta by immunohistochemical analysis. (1991) (63)
Sequence of a cDNA coding for human IRF-1. (1989) (62)
Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice (2018) (61)
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis (2016) (60)
Toll‐like receptor signaling and IRF transcription factors (2006) (60)
Placental interleukin-6 production is enhanced in intrauterine infection but not in labor. (1993) (59)
Inhibition of Qβ RNA 70S ribosome initiation complex formation by an oligonucleotide complementary to the 3′ terminal region of E. coli 16S ribosomal RNA (1978) (58)
1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression (2009) (57)
Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells. (1982) (57)
Critical role for constitutive type I interferon signaling in the prevention of cellular transformation (2009) (57)
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling. (2001) (56)
BH3‐only proteins: Integrated control point of apoptosis (2006) (56)
IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor a (1995) (56)
IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. (1995) (55)
Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus. (2001) (54)
Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis (2015) (54)
Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs) (2011) (54)
Transcription factors IRF‐1 and IRF‐2: Linking the immune responses and tumor suppression (1997) (54)
Possible involvement of the transcription factor ISGF3γ in virus‐induced expression of the IFN‐β gene (1995) (50)
Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis (2015) (48)
Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor β chain (1997) (47)
A Critical Role for Cyclin C in Promotion of the Hematopoietic Cell Cycle by Cooperation with c-Myc (1998) (47)
Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31. (1991) (46)
Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. (2004) (44)
DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1. (1997) (44)
Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-&ggr; by means of dna microarray1 (2002) (43)
Synthesis and secretion of biologically active mouse Interferon-β using a Bacillus subtilis α-amylase secretion vector (1985) (43)
Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene (2009) (42)
Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain. (1994) (42)
S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification (2016) (41)
New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism. (2003) (41)
Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction (2012) (41)
IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II‐induced hypertension (2011) (40)
Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene (1994) (40)
Stat1‐mediated cytoplasmic attenuation in osteoimmunology (2005) (39)
The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. (1983) (39)
Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. (1989) (39)
Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal. (1990) (36)
A potential contribution of antimicrobial peptide LL‐37 to tissue fibrosis and vasculopathy in systemic sclerosis (2016) (35)
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. (1996) (35)
Partial characterization of gamma (immune) interferon mRNA extracted from human lymphocytes. (1981) (35)
The interferon family stimulates the secretions of prolactin and interleukin-6 by the pituitary gland in vitro (1991) (34)
The interleukin-2 receptors: insights into a complex signalling mechanism. (1992) (34)
Regulation of the interferon system and cell growth by the IRF transcription factors (2005) (33)
Interleukin‐8 level in maternal serum as a marker for screening of histological chorioamnionitis at term (1997) (33)
Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene. (1989) (32)
Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in prothrombotic conditions (2016) (32)
Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis (2017) (31)
A possible contribution of lipocalin‐2 to the development of dermal fibrosis, pulmonary vascular involvement and renal dysfunction in systemic sclerosis (2015) (31)
Histological features of localized scleroderma ‘en coup de sabre’: a study of 16 cases (2014) (31)
Sequence of a cDNA coding for human IRF-2. (1989) (30)
Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth. (2011) (30)
Fetal mononuclear cells show a comparable capacity with maternal mononuclear cells to produce IL-8 in response to lipopolysaccharide in chorioamnionitis. (1993) (29)
Transcription factor IRF-1 and its family members in the regulation of host defense. (1999) (29)
Construction and identification of a hybrid plasmid containing DNA sequence complementary to phenobarbital-inducible cytochrome P-450 messenger RNA from rat liver. (1981) (29)
Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. (2008) (27)
Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells (1997) (26)
Effects of bosentan on nondigital ulcers in patients with systemic sclerosis (2012) (26)
Efficient expression in Escherichia coli of a mature and a modified human interferon-beta 1. (1984) (25)
Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment (2016) (24)
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response (2015) (23)
Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1 (2009) (23)
Human interleukin 2 (IL 2) receptor β chain allows transduction of IL 2‐induced proliferation signal(s) in a murine cell line (1989) (23)
Serum levels of ADAM12‐S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis (2013) (22)
Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. (2013) (22)
Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family. (1998) (21)
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation (2010) (21)
Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells (2009) (21)
Regulation of interferon-beta gene: structure and function of cis-elements and trans-acting factors. (1989) (20)
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells (2021) (20)
Regulation of the interferon system, immune response and oncogenesis by the transcription factor interferon regulatory factor-1. (1998) (19)
Clinical significance of serum retinol binding protein‐4 levels in patients with systemic sclerosis (2013) (19)
Secondary structure and folding topology of the DNA binding domain of interferon regulatory factor 2, as revealed by NMR spectroscopy (1995) (18)
Escherichia coli ribosomes bind to non-initiator sites of Q beta RNA in the absence of formylmethionyl-tRNA. (1979) (18)
Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor–mediated enhancement of the MKP-IRF3 axis (2013) (18)
A case of taxane‐induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis (2011) (17)
The interleukin-2 receptor complex and signal transduction: role of the β-chain (1993) (17)
Significance of chorioamnionitis. (1992) (17)
Cellular and genetic analyses of IL-2 production and IL-2 receptor expression in a patient with familial T-cell-dominant immunodeficiency. (1988) (17)
New approaches for the high-level expression of human interleukin-2 cDNA in Escherichia coli. (1987) (17)
Functional interleukin 2 receptors on B cells lacking Tac antigens (1987) (17)
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction. (1998) (17)
Critical role of the membrane‐proximal, proline‐rich motif of the interleukin‐2 receptor γc chain in the Jak3‐independent signal transduction (1999) (15)
Construction and application of a novel plasmid "ATG vector" for direct expression of foreign genes in Escherichia coli. (1983) (15)
IRF-1 and IRF-2 as regulators of the interferon system and cell growth. (1995) (15)
The role of the BH3-only protein Noxa in bone homeostasis. (2011) (15)
Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis (2019) (14)
Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis (2012) (14)
Characterization of the DNA binding domain of the mouse IRF-2 protein. (1993) (14)
Structure and function of IL-2 and IL-2 receptors. (1992) (13)
Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus (2017) (13)
Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor γ (1993) (13)
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease (2021) (13)
IL‐2‐induced gene expression of protein‐tyrosine phosphatase LC‐PTP requires acidic and serine‐rich regions within IL‐2 receptor β chain (1995) (12)
Novel pegylated interferon‐β as strong suppressor of the malignant ascites in a peritoneal metastasis model of human cancer (2017) (12)
Construction of plasmid expression vectors carrying the Escherichia coli tryptophan promoter. (1984) (12)
Nucleotide sequence of the mouse interferon-β gene (1989) (11)
Reversed genetics: a new approach to the elucidation of structure--function relationship. (1979) (11)
Unprecedented success of rituximab therapy for prednisolone- and immunosuppressant-resistant systemic sclerosis-associated interstitial lung disease (2017) (10)
Constitutive activation of c‐Abl/protein kinase C‐δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma (2012) (10)
The Use of Site-Directed Mutagenesis in Reversed Genetics (1979) (9)
[IRF family transcription factors and host defense signaling]. (2008) (9)
IRF family transcription factors in type I interferon induction (2005) (9)
A Qbeta DNA-containing hybrid plasmid giving rise to Qbeta phage formation in the bacterial host [proceedings]. (1978) (8)
Assignment of the interleukin-2 receptor β chain gene (II-2rb) to band E on mouse chromosome 15 (1992) (8)
Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene. (1995) (8)
correction: Requirement for IRF-1 in the microenvironment supporting development of natural killer cells (1998) (7)
A potential contribution of psoriasin to vascular and epithelial abnormalities and inflammation in systemic sclerosis (2018) (7)
Candidate Mediator of p 53-Induced Apoptosis Noxa , a BH 3-Only Member of the Bcl-2 Family (2010) (7)
DYSREGULATION OF GROWTH FACTOR‐RECEPTOR SYSTEM IN CELLULAR TRANSFORMATION (1988) (7)
6 – SITE-DIRECTED MUTAGENESIS AS A TOOL IN GENETICS (1978) (7)
Application of site-directed mutagenesis to RNA and DNA genomes. (1979) (6)
Novel chemical compound SINCRO with dual function in STING‐type I interferon and tumor cell death pathways (2018) (6)
EXPRESSION OF CLONED VIRAL AND CHROMOSOMAL PLASMID-LINKED DNA IN COGNATE HOST CELLS (1979) (6)
Establishment of human interleukin-4 producing chinese hamster ovary cells (1988) (6)
HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis (2020) (6)
The first case report of fatal acute pulmonary dysfunction in a systemic sclerosis patient treated with rituximab (2016) (5)
Signal‐transducing innate receptors in tumor immunity (2021) (5)
Expression of HTLV-I gag Protein in Escherichia coli (1988) (5)
Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury (2021) (5)
Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis (2021) (5)
Interleukin-2 and its receptor: structure and functional expression of the genes. (1986) (5)
Nod 2-Independent Mechanism Bacteria Is Mediated by a TLR-and Induction of Type I IFNs by Intracellular IFN Regulatory Factor 3-Dependent (2004) (4)
EXPRESSION OF THE CLONED GENES FOR HUMAN INTERFERON β 1 IN E. COLI AND IN CULTURED MOUSE CELLS (1982) (4)
Expression of human T-cell leukemia virus type I envelope protein in Saccharomyces cerevisiae. (1986) (4)
Structure and expression of a cloned cDNA for human interleukin-2. 1983. (1992) (4)
Author response: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses (2014) (4)
[Involvement of positive (IRF-1) and negative (IRF-2) transcription factors in the gene regulation of the type I interferon system]. (1992) (4)
Synthesis and secretion of biologically active mouse interferon-beta using a Bacillus subtilis alpha-amylase secretion vector. (1985) (3)
Erratum: The contribution of transcription factor IRF1 to the interferon-γ-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells (Nature Immunology (2008) vol. 9 (34-41) 10.1038/ni1538) (2008) (3)
A potential contribution of trappin‐2 to the development of vasculopathy in systemic sclerosis (2019) (3)
Assignment of the interleukin-2 receptor beta chain gene (Il-2rb) to band E on mouse chromosome 15. (1992) (3)
High Power Laser Diode Arrays for pumping Solid State Laser (1996) (3)
Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors (3)
CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX. (1999) (3)
Molecular Cloning of a Complementary DNA of Phenobarbital-Inducible Cytochrome P-450 Messenger RNA from the Rat (1980) (2)
Regulation of cytokine gene expression: gene activation in type I IFN and IL-2 systems. (1988) (2)
Fine-tuning type I IFN signaling: A new chapter in the IFN saga (2017) (2)
Type I interferon system and IRF family of transcription factors in host defense regulation (2005) (2)
Structure and Regulation of the Genes Encoding Interleukin-2 and its Receptor (1986) (2)
The interleukin-2 receptor complex and signal transduction: role of the beta-chain. (1993) (2)
Detection of mitochondrial DNA deletion in the late-term placenta. (1996) (2)
Molecular structure of interleukin 6 receptor. (1988) (2)
Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma. (1993) (2)
Leukaemic variant of cutaneous T‐cell lymphoma with CD3− CD4+ phenotype (2012) (2)
Systemic Viral Infection CD11c-Positive Dendritic Cells Establish CD46/CD150-Transgenic Mice: Wild-Type Measles Virus Infection in Human (2005) (1)
Partial characterization of y ( immune ) interferon mRNA extracted from human lymphocytes ( 12-0-tetradecanoylphorbol 13-acetate / phytohemagglutinin / Xenopus laevis oocytes / lymphokines / lymphocyte cultures ) (1)
Nucleotide sequence of the mouse interferon-beta gene. (1989) (1)
Aimez-vous Brahms? A story capriccioso from the discovery of a cytokine family and its regulators (2009) (1)
In vivo role of HMGB1 in endotoxemia and bacterial infection (IRC5P.454) (2014) (1)
Molecular cloning and coding nucleotide sequence of complementary DNA of cytochrome P-450 involved in metabolic activation of carcinogenic substances. (1982) (1)
Production of immunoreactive 2',5'-oligoadenylate synthetase in p48-deficient mice. (1998) (1)
Regulation of the interleukin-2 system and T cell neoplasm. (1988) (1)
Application of site-directed mutagenesis to ribonucleic acid and deoxyribonucleic acid genomes. (1979) (1)
25 years after the dawn of cytokine molecular biology: roles of IRF transcription factors in toll-like receptor-mediated gene-expression program. (2005) (1)
IRF-1 Functions as a Tumor Suppressor (1995) (1)
A new soybean [Glycine max] variety 'Suzuroman' (2008) (1)
Two Step Activation of the Interleukin-2 Autocrine Loop May be Involved in ATL Development (1987) (1)
Damage-associated molecular patterns and Toll-like receptors in the tumor immune microenvironment. (2021) (1)
Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Misdeeds in Oncogenesis (2015) (1)
PLACENTAL PRODUCTION OF MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR (MCAF) AND ITS ENHANCEMENT BY CHORIOAMNIONITIS (1993) (0)
Expression of HTLV-IgagProtein inEscherichia coli (1988) (0)
[Structure and expression of the cloned genes for human interferon]. (1982) (0)
INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES (1998) (0)
INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE (1998) (0)
DNA, recombinant plasmid and microorganism containing the same as well as methods for their preparation (1980) (0)
bc1-2 Gene Expression induced by IL-2 is Critical for the Cell Cycle Progression of the Hematopoietic Cell (1996) (0)
antigen peptide adult-T-cell leukemiavirus derivative of. (1985) (0)
[Round-table talk in commemoration of the 60th anniversary of the Japanese Biochemical Society. (1). Biochemistry: present, past and future]. (1986) (0)
The sequence of human interferon-3,1 gene is responsible for viral induction of transription (2003) (0)
ID: 84: Innate immune responses in the regulation of tumor development (2015) (0)
Structure andRegulation oftheHumanInterferon Regulatory Factor 1(IRF-1) andIRF-2Genes: Implications for a GeneNetworkintheInterferon System (1994) (0)
Unique Structure of the DNA Binding Domain of Interferon Regulatory Factor 2 Determined by NMR Spectroscopy. (1994) (0)
[Treatment of habitual abortion by the mixture of paternal leukocytes and OK-432]. (1990) (0)
INTERFERONS AND IRF FAMILY OF TRANSCRIPTION FACTORS IN THE REGULATION OF IMMUNITY (2005) (0)
Structure and Function of the Human Interleukin-2 Receptor (1986) (0)
The recombinant interleukin-2 receptor (1990) (0)
Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2 (1994) (0)
[Studies of human interferon (author's transl)]. (1982) (0)
Adult t-cell leukemiavirus antigen polypeptide. (1985) (0)
Transient induction of IL-2 receptor in cultured T cell lines by HTLV-1 LTR-linked tax-1 gene. (1989) (0)
KEY-2 30 Years after the dawn of cytokine molecular biology: Roles of IRF transcription factors (2008) (0)
B.C., D.C., and A.C. of an interferon gene. (1987) (0)
[Immunobiological characteristics of germfree mice (author's transl)]. (1978) (0)
Molecular Structure o f Interleukin 6 Receptort (2006) (0)
[IL-2 system in B lymphocyte growth and differentiation]. (1991) (0)
Transcriptional regulation of the immune response and oncogenesis by IRF-1 and its family members (1997) (0)
REGULATION OF THE HOST DEFENSE MECHANISMS BY THE IRF-FAMILY TRANSCRIPTION FACTORS (1996) (0)
Prognostic factors of tubal microsurgery (1991) (0)
70 Requirement of IL-12RB1 Induction by IRF1 for IL-12 Responsiveness and TH1 Differentiation (2007) (0)
IL-2-Induced Signal Transduction in an Oligodendroglioma Line (1991) (0)
Human interferon-gamma polypeptide and process for their preparation, recombinant plasmid comprising a DNA fragment coding for the peptide, and the microorganism transformed with the plasmid (1984) (0)
Antiviral Action of TNF in Human Fibroblasts Requires the Presence of Subeffective Concentrations of Classical Interferon‐β a (1989) (0)
381 Fli1 deficiency promotes CXCL13 expression from macrophages, contributing to the development of systemic sclerosis (2017) (0)
Identification and analysis of commensal bacteriophage in the intestine (2017) (0)
The impact of IRF5 deficiency on fibrosis, vasculopathy, and immune abnormality in a bleomycin-treated murine model of systemic sclerosis (2016) (0)
Regulation of the interferon system and immune responses by the IRF family transcription factors (2000) (0)
298 Fli1-deficient adipocytes promote the spontaneous development of dermal fibrosis and vasculopathy mimicking systemic sclerosis through adipocytes-to-myofibroblast transdifferentiation and defective vasculogenesis (2017) (0)
IL-12 mediated protection in IRF-1-1-mice during blood stage p. berghei infection (1998) (0)
227 Analysis of mechanism for interleukin-1 (IL-1) : induced hCG release by trophoblast (1991) (0)
20 Analysis of role of IRF-1 gene in skin tumor induced by chemical treatment (1996) (0)
287 The micro-fluidics reveals the role of vascular endothelium-specific B cells in cutaneous leukocytoclastic vasculitis (2016) (0)
A critical link between Lyn-mediated suppression of the TLR-MyD88-IRF5 pathway and the development of SLE-like disease (2016) (0)
[The thymus and lymphatic tissue in development]. (1965) (0)
FRI0266 Hemodynamic complications in systemic sclerosis patients with various stages of pulmonary arterial hypertension (2013) (0)
437 αE integrin contributes to the pathological dermal fibrosis in a bleomycin-treated murine model of systemic sclerosis via the activation of retinoic acid pathway (2016) (0)
[Cellular responses by cytokines--gene regulation in the IFN system]. (1991) (0)
OP0087 Platelet-specific fli1-knockout mice show accelerated wound closure associated with increased myofibroblast formation in the inflammatory phase (2017) (0)
897 Abnormally activated angiogenesis and impaired vasculogenesis underlie the vasculopathy in Fli1/Klf5 double-heterozygote knockout mice, a new animal model of systemic sclerosis (2017) (0)
Potential of HMGB‐inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis (2022) (0)
347 Regulation of innate immune responses by DAI (DLM-1/ ZBP1) and other DNA-sensing molecules (2008) (0)
Analogifremgangsmaade for the production of interferon gamma polypeptide, a DNA sequence coding therefor, plasmid containing DNA sequence and a microorganism containing the plasmid (1983) (0)
Innate Immunity 1 (Innate receptors) (SY1-1) Chairpersons: Shizuo Akira, Ruslan Medzhitov (2010) (0)
Abstract 242: TCTP is a target for cancer immunotherapy modulating myeloid-derived suppressor cells (2022) (0)
[Cytokine signal transduction and expression of cell cycle related genes]. (1994) (0)
Molecular Biology of Interleukin-2 and Its Receptor: The Current Status (1986) (0)
Evidence fora Critical RolefortheCytoplasmic Regionofthe Interleukin 2(IL-2) Receptor -yChaininIL-2, IL-4, andIL-7Signalling (1994) (0)
The IL-2 Receptor and its Target Genes in Hematopoietic Cell Cycle (1993) (0)
IN VIVO AND IN VITRO ANALYSIS OF MECHANISM FOR THE ENHANCED PRODUCTION OF IL-1 FROM THE TROPHOBLAST DURING INTRAUTERINE INFECTION (1991) (0)
Innate Immune Receptors in the Regulation of Tumor Immunity (2018) (0)
Unglycosylated human fibroblast interferon and a method for manufacturing the same (1981) (0)
Abstract 4056: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses (2015) (0)
Regulation of inflammation and oncogenesis by the IRF family transcription factors (2013) (0)
EXPRESSION OF THE HUMAN INTERFERON-β1 GENE IN HETEROLOGOUS HOST CELLS (1983) (0)
Dns and these containing recombinant plasmid. (1983) (0)
serine- rich region within IL-2 receptor beta c chain Interleukin-2 (IL-2) upregulates BAG-1 gene expression through (2011) (0)
Polypeptide associated with rIL-2 and DNA molecules encoding this. (1995) (0)
Identification of immunogenic RNA and its inhibitor (2017) (0)
Interferons and IRF/Stat transcription factors in the regulation of immunity, oncogenesis and bone remodeling (2003) (0)
A method for diagnosis of cancer or precancer detection by IRF-1 specific RNA (1995) (0)
[Interleukin 2 and interleukin 2 receptors]. (1991) (0)
Interferon system and IRF family transcription factors in oncogenesis and immunity. (2006) (0)
The efficacy of dantrolene sodium for muscle cramps in patients with localized scleroderma (2016) (0)

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