Taiji Imoto
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Physical Chemistry
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Organic Chemistry
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Chemistry
Taiji Imoto's Degrees
- PhD Chemistry University of Tokyo
- Masters Chemistry University of Tokyo
- Bachelors Chemistry University of Tokyo
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(Suggest an Edit or Addition)Taiji Imoto's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Simple Activity Measurement of Lysozyme (1971) (661)
- Long-Range Interactions Within a Nonnative Protein (2002) (552)
- 21 Vertebrate Lysozymes (1972) (258)
- Fluorescence of lysozyme: emissions from tryptophan residues 62 and 108 and energy migration. (1972) (235)
- Protein unfolding at interfaces: Slow dynamics of α‐helix to β‐sheet transition (2004) (136)
- Amino acid sequences of lysozymes newly purified from invertebrates imply wide distribution of a novel class in the lysozyme family. (1999) (132)
- A convenient synthesis of glycolchitin, a substrate of lysozyme. (1981) (123)
- The position of the active tryptophan residue in lysozyme. (1965) (112)
- Selective modification of aspartic acid-101 in lysozyme by carbodiimide reaction. (1981) (96)
- Construction of a plasmid vector for the regulatable high level expression of eukaryotic genes in Escherichia coli: an application to overproduction of chicken lysozyme. (1987) (93)
- Multiple role of hydrophobicity of tryptophan-108 in chicken lysozyme: structural stability, saccharide binding ability, and abnormal pKa of glutamic acid-35. (1992) (81)
- Effective renaturation of reduced lysozyme by gentle removal of urea. (1995) (79)
- Internal motion of lysozyme studied by time-resolved fluorescence depolarization of tryptophan residues. (1998) (79)
- Unfolding rates of globular proteins determined by kinetics of proteolysis. (1986) (77)
- Effect of buffer species on the unfolding and the aggregation of humanized IgG. (2007) (73)
- Effect of additives on the renaturation of reduced lysozyme in the presence of 4 M urea. (1996) (69)
- Regiospecific A,B capping onto .beta.-cyclodextrin. Characteristic remote substituent effect on carbon-13 NMR chemical shift and specific Taka-amylase hydrolysis (1985) (62)
- Crystal Structure of Tapes japonica Lysozyme with Substrate Analogue (2007) (61)
- Stabilization of protein (1997) (59)
- Modulation of compactness and long-range interactions of unfolded lysozyme by single point mutations. (2004) (56)
- Insect lysozyme from house fly (Musca domestica) larvae: possible digestive function based on sequence and enzymatic properties. (1995) (56)
- Depression of T-cell Epitope Generation by Stabilizing Hen Lysozyme* (1997) (55)
- The relationship between the aggregational state of the amyloid‐β peptides and free radical generation by the peptides (2001) (55)
- THE ENZYME-SUBSTRATE COMPLEX IN A MURAMIDASE CATALYZED REACTION. I. DIFFERENCE SPECTRUM OF COMPLEX. (1963) (54)
- Stabilization of hen egg white lysozyme by a cavity‐filling mutation (2001) (48)
- 6A6B, 6A6C, and 6A6D-ditosylates of β-cyclodextrin (1985) (48)
- A Protein’s Conformational Stability Is an Immunologically Dominant Factor: Evidence That Free-Energy Barriers for Protein Unfolding Limit the Immunogenicity of Foreign Proteins (2010) (47)
- The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme. (1993) (47)
- High‐level expression of uniformly 15N‐labeled hen lysozyme in Pichia pastoris and identification of the site in hen lysozyme where phosphate ion binds using NMR measurements (1999) (46)
- The mechanism of irreversible inactivation of lysozyme at pH 4 and 100 degrees C. (1994) (45)
- Regiospecific sulfonation onto C-3 hydroxyls of .beta.-cyclodextrin. Preparation and enzyme-based structural assignment of 3A,3C and 3A3D disulfonates (1986) (44)
- Purification and Some Properties of Chitinases from Yam, Dioscorea opposita Thumb (1984) (44)
- Analysis of the relationship between enzyme activity and its internal motion using nuclear magnetic resonance: 15N relaxation studies of wild-type and mutant lysozyme. (1999) (44)
- Aggregation and chemical reaction in hen lysozyme caused by heating at pH 6 are depressed by osmolytes, sucrose and trehalose. (2001) (44)
- Synthesis of 6A,6X-di-O-(p-tosyl)-.gamma.-cyclodextrins and their structural determination through enzymic hydrolysis of 3A,6A;3X,6X-dianhydro-.gamma.-cyclodextrins (1988) (43)
- POLYMERIC INCLUSION COMPOUND DERIVED FROM β-CYCLODEXTRIN (1982) (42)
- The binding groups in ovomucin-lysozyme interaction. (1975) (42)
- Oxidation of lysozyme by iodine: identification and properties of an oxindolyl ester intermediate: evidence for participation of glutamic acid 35 in catalysis. (1973) (40)
- A small chimerically bifunctional monomeric protein: Tapes japonica lysozyme (2003) (39)
- Isolation and characterization of 101-succinimide lysozyme that possesses the cyclic imide at Asp101-Gly102. (1994) (38)
- Oxidation of lysozyme by iodine: isolation of an inactive product and its conversion to an oxindolealanine-lysozyme. (1973) (37)
- Investigation of the Structural Basis for Thermostability of DNA-binding Protein HU from Bacillus stearothermophilus * (1998) (37)
- Multiple proteolytic action of rat liver cathepsin B: specificities and pH-dependences of the endo- and exopeptidase activities. (1991) (37)
- Endo- and aminopeptidase activities of rat cathepsin H. (1992) (36)
- Improvement of the refolding yield and solubility of hen egg-white lysozyme by altering the Met residue attached to its N-terminus to Ser. (1997) (36)
- Contribution of conformational stability of hen lysozyme to induction of type 2 T‐helper immune responses (2001) (35)
- A mutation study of catalytic residue Asp 52 in hen egg lysozyme. (1996) (35)
- A method for the detection of asparagine deamidation and aspartate isomerization of proteins by MALDI/TOF-mass spectrometry using endoproteinase Asp-N. (2003) (35)
- Lysozyme requires fluctuation of the active site for the manifestation of activity. (1994) (35)
- 6A6B-, 6A6C-, and 6A6D-disulfonates of .alpha.-cyclodextrin (1984) (34)
- Stabilization of lysozyme against irreversible inactivation by suppression of chemical reactions. (1995) (34)
- Stabilization of a protein by removal of unfavorable abnormal pKa: substitution of undissociable residue for glutamic acid-35 in chicken lysozyme. (1992) (34)
- Guest-induced conformational change of β-cyclodextrin capped with an environmentally sensitive chromophore (1982) (34)
- 6-Polysubstituted α-Cyclodextrins. Application of Körner′s Absolute Method of Isomer Determination. (1986) (33)
- Fully collaborative guest binding by a double cyclodextrin host (1984) (33)
- Effect of salt concentration on the pKa of acidic residues in lysozyme. (1995) (33)
- Endopeptidase activity of cathepsin C, dipeptidyl aminopeptidase I, from bovine spleen. (1993) (32)
- An intramolecular cross-linkage of lysozyme. Formation of cross-links between lysine-1 and histidine-15 with bis(bromoacetamide) derivatives by a two-stage reaction procedure and properties of the resulting derivatives. (1985) (32)
- Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine. (2000) (30)
- Convenient preparation and effective separation of the C-2 and C-3 tosylates of α-cyclodextrin (1985) (30)
- Protein unfolding at interfaces: slow dynamics of alpha-helix to beta-sheet transition. (2004) (29)
- In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI-motif). (1999) (29)
- Tolerance of point substitution of methionine for isoleucine in hen egg white lysozyme. (2001) (29)
- A convenient protein substrate for the determination of protease specificity: reduced and S-3-(trimethylated amino)propylated lysozyme. (1985) (28)
- Effective renaturation of denatured and reduced immunoglobulin G in vitro without assistance of chaperone. (1996) (28)
- Colorimetric assay for lysozyme using Micrococcus luteus labeled with a blue dye, Remazol brilliant blue R, as a substrate. (1992) (28)
- Chemical mutations of the catalytic carboxyl groups in lysozyme to the corresponding amides. (1986) (28)
- Effects of signal sequences on the secretion of hen lysozyme by yeast: construction of four secretion cassette vectors. (1998) (27)
- A convenient S-2-aminoethylation of cysteinyl residues in reduced proteins. (1985) (27)
- Resolution and characterization of tryptophyl fluorescence of hen egg-white lysozyme by quenching- and time-resolved spectroscopy. (1999) (27)
- A particular hydrophobic cluster in the residual structure of reduced lysozyme drastically affects the amyloid fibrils formation. (2007) (27)
- Chitin Coated Cellulose as an Adsorbent of lysozyme like Enzymes Preparation and Properties (1973) (26)
- An S-alkylating reagent with positive charges as an efficient solubilizer of denatured disulfide-containing proteins. (1994) (26)
- Effect of the structure of the denatured state of lysozyme on the aggregation reaction at the early stages of folding from the reduced form. (2005) (26)
- Estimation of rate constants in lysozyme-catalyzed reaction of chitooligosaccharides. (1981) (26)
- Stabilization of lysozyme by the introduction of Gly-Pro sequence. (1993) (25)
- Synthesis of specifically modified maltooligosaccharides by enzymatic degradation of cyclodextrin derivatives. Substrate-based investigation of the active site of Taka-amylase (1987) (25)
- Point mutation of alanine (31) to valine prohibits the folding of reduced lysozyme by sulfhydryl-disulfide interchange. (1987) (24)
- Engineering of lysozyme. (1996) (24)
- Amyloid-β-protein (Aβ) (25–35)-associated free radical generation is strongly influenced by the aggregational state of the peptides (2002) (24)
- Effects of Additives on Irreversible Inactivation of Lysozyme at Neutral pH and 100° C (1995) (23)
- Chitin-coated Celite as an affinity adsorbent for high-performance liquid chromatography of lysozyme. (1985) (23)
- Regiospecific sulfonation of secondary hydroxyl groups of .alpha.-cyclodextrin. Its application to preparation of 2A2B, 2A2C-, and 2A2D-disulfonates (1985) (23)
- Stabilization of lysozyme against irreversible inactivation by alterations of the Asp-Gly sequences. (1995) (23)
- Purification, amino acid sequence, and some properties of rabbit kidney lysozyme. (1990) (23)
- Remarkable thermal stability of doubly intramolecularly cross-linked hen lysozyme. (2000) (22)
- Lysozyme-catalyzed reaction of chitooligosaccharides. (1981) (22)
- Reduced immunogenicity of monomethoxypolyethylene glycol-modified lysozyme for activation of T cells. (1996) (21)
- Modification of catalytic groups in lysozyme with ethylenimine. (1982) (21)
- Insertion of the Dibasic Motif in the Flanking Region of a Cryptic Self-Determinant Leads to Activation of the Epitope-Specific T Cells1 (2005) (21)
- Isolation and characterization of 101-beta-lysozyme that possesses the beta-aspartyl sequence at aspartic acid-101. (1985) (21)
- Characterization of enzyme-substrate complex of lysozyme. I. Two types of complex. (1968) (21)
- Specific preparation and structure determination of 3A,3C,3E-tri-O-sulfonyl-.beta.-cyclodextrin (1990) (21)
- A study of the native-denatured (N⇌D) transition in lysozyme I. Detection of the transition by product analyses of protease digests (1974) (20)
- Refolding of an unstable lysozyme by gradient removal of a solubilizer and gradient addition of a stabilizer. (2010) (20)
- The inhibitory interaction of cationic detergents with the active center of lysozyme. I. Site of interaction. (1968) (20)
- A Covalent Enzyme-Substrate Adduct in a Mutant Hen Egg White Lysozyme (D52E)* (1997) (20)
- Stabilization of lysozyme by introducing N-glycosylation signal sequence. (1996) (20)
- Left-sided substrate binding of lysozyme: evidence for the involvement of asparagine-46 in the initial binding of substrate to chicken lysozyme. (1992) (20)
- Structural study of monosubstituted β-cyclodextrins. crystal structures of phenylthio-β-cyclodextrin and phenylsulphinyl-β- cyclodextrin and spectroscopic study of related compounds in aqueous solution (1987) (20)
- Comparative study on specificities of rat cathepsin L and papain: amino acid differences at substrate-binding sites are involved in their specificities. (1990) (19)
- Iodination of lysozyme. II. Reactivity and position of tyrosine residues. (1968) (19)
- Prevention of collagen‐induced arthritis (CIA) by treatment with polyethylene glycol‐conjugated type II collagen; distinct tolerogenic property of the conjugated collagen from the native one (1997) (19)
- The molecular weight ratio of monomethoxypolyethylene glycol (mPEG) to protein determines the immunotolerogenicity of mPEG proteins. (1999) (19)
- Hydrolysis of phenyl acetates with capped .beta.-cyclodextrins: reversion from meta to para selectivity (1980) (19)
- Analysis of the internal motion of free and ligand‐bound human lysozyme by use of 15N NMR relaxation measurement: A comparison with those of hen lysozyme (2000) (18)
- The inhibitory interaction of cationic detergents with the active center of lysozyme. II. The pH dependence of the interaction. (1968) (18)
- Effect of Sucrose on Formation of the β-Amyloid Fibrils and D -Aspartic Acids in Aβ 1—42 (2002) (18)
- Intramolecular cross-linkage of lysozyme. Imidazole catalysis of the formation of the cross-link between lysine-13 (epsilon-amino) and leucine-129 (alpha-carboxyl) by carbodiimide reaction. (1983) (17)
- Solution structure and activity of mouse lysozyme M (2003) (17)
- Preparation of 3A,6A-Anhydro-β-cyclodextrin and Its Taka Amylolysis (1988) (17)
- Analysis of the early stage of the folding process of reduced lysozyme using all lysozyme variants containing a pair of cysteines. (2004) (17)
- Amyloid formation in denatured single‐mutant lysozymes where residual structures are modulated (2006) (16)
- Analysis of the stabilization of hen lysozyme by helix macrodipole and charged side chain interaction. (1997) (16)
- 1:2 host-guest binding by double γ-cyclodextrin (1985) (16)
- Determination of the secondary structure in solution of the Escherichia coli DnaA DNA-binding domain. (2002) (16)
- Situation of monomethoxypolyethylene glycol covalently attached to lysozyme. (1996) (15)
- Improving enzyme characteristics by gene shuffling; application to β-glucosidase (2001) (15)
- The role of net charge on the renaturation of reduced lysozyme by the sulfhydryl-disulfide interchange reaction. (1994) (15)
- Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity (1999) (15)
- Robustness of hen lysozyme monitored by random mutations. (2002) (15)
- A complete set of β -cyclodextrins 6A, 6X-diactivated by two different sulfonyl groups (1991) (15)
- REGIOSPECIFIC SULFONATION OF SECONDARY HYDROXYL GROUPS OF α-CYCLODEXTRIN. ITS APPLICATION TO PREPARATION OF 2A2B, 2A2C-, AND 2A2D-DISULFONATES (1985) (15)
- Effect of chemical modifications of tryptophan residues on the folding of reduced hen egg-white lysozyme. (1990) (14)
- Selectivity variation in hydrolysis of phenyl acetates by simple modifications of β-cyclodextrin. (1980) (14)
- Structure of lysozyme. X. On the structural role of tryptophan residues. (1965) (14)
- A Study of the Native-Denatured (N⇌D) Transition in LysozymeII. Kinetic Analysis of Protease Digestion (1976) (14)
- Specificity of rat liver cathepsin D. (1987) (13)
- Amino acid residues in subsites e and f responsible for the characteristic enzymatic activity of duck egg-white lysozyme. (2002) (13)
- Binding of calcium to lysozyme and its derivatives. (1981) (13)
- Colonic lysozymes of rabbit (Japanese white): recent divergence and functional conversion. (1994) (13)
- Thermodynamic and kinetic stabilities of hen-egg lysozyme and its chemically modified derivatives: analysis of the transition state of the protein unfolding. (1993) (13)
- Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides. (2002) (12)
- Enzymatic synthesis of specifically modified linear oligosaccharides from γ-cyclodextrin derivatives. Study on importance of active sites of Taka amylase A (1989) (12)
- Enzyme-based discrimination between clockwise and counterclockwise isomers of unsymmetrically disubstituted β-cyclodextrins. 6A,6B- and 6A,6G-derivatives (1985) (12)
- Elucidation of the relationship between enzyme activity and internal motion using a lysozyme stabilized by cavity-filling mutations (2005) (11)
- Identification of the peptide region that folds native conformation in the early stage of the renaturation of reduced lysozyme. (1996) (11)
- Selective recognition of alkanoates by a β-cyclodextrin flexibly capped with a chromophore (1982) (10)
- Mutant Mouse Lysozyme Carrying a Minimal T Cell Epitope of Hen Egg Lysozyme Evokes High Autoantibody Response (2000) (10)
- Optical properties of lysozyme. pH and saccharide binding difference spectra. (1975) (10)
- Kinetic measurement of the interaction between a lysozyme and its immobilized substrate analogue by means of surface plasmon resonance. (1998) (10)
- Dinitrophenylation as a probe for the determination of environments of amino groups in protein. Reactivities of individual amino groups in lysozyme. (1986) (10)
- Effect of the Conformational Stability of the CH2 Domain on the Aggregation and Peptide Cleavage of a Humanized IgG (2011) (10)
- Formation of alpha-helix 88-98 is essential in the establishment of higher-order structure from reduced lysozyme. (1994) (10)
- Expression and characterization of human rheumatoid factor single-chain Fv. (2000) (10)
- Inhibitory effect of the extract from Zizyphus jujuba leaves on sweet taste responses of the chorda tympani in the rat and hamster. (1987) (9)
- Unsymmetrically disubstituted .beta.-cyclodextrins of 6A,6X-dideoxy-6A-azido-6X-[(mesitylsulfonyl)oxy] derivatives (1985) (9)
- Identification of the region in Escherichia coli DnaA protein required for specific recognition of the DnaA box (2003) (9)
- Nature of the binding site around and reactivity of histidine-15 in lysozyme. (1984) (9)
- Functional and Structural Effects of Mutagenic Replacement of Asn37 at Subsite F on the Lysozyme-catalyzed Reaction (2004) (9)
- Construction of a yeast expression system with positive selection for gene insertion in the absence of a specific phenotype. (1998) (9)
- Synthesis of a di-oxygen [18]annulene: A new example of strongly diatropic [18]annulene with a twisted perimeter (1983) (9)
- Analysis of the Reaction between Formaldehyde and Amide (1978) (9)
- A study of the native-denatured (N in equilibrium with D) transition in lysozyme. III. Effect of alteration of net charge by acetylation. (1976) (9)
- Identification of an abnormal hemoglobin with reduced oxygen affinity by high-performance liquid chromatography. (1981) (8)
- A simple peptide fractionation by hydrophobic chromatography with a prepacked reversed-phase column. (1981) (8)
- Evidence for an initiation site for hen lysozyme folding from the reduced form using its dissected peptide fragments. (2001) (8)
- An analysis of the interaction of sodium dodecyl sulfate with lysozyme. (1979) (8)
- Characterization of enzyme-substract complex of lysozyme. II. Effects of pH and salts. (1969) (8)
- Separation of peptides by cellulose-phosphate chromatography for identification of a hemoglobin variant. (1982) (8)
- A complete set of 6A-azido-6A-deoxy-6X-0-sulfonyl-β0-cyclodextrins (1992) (8)
- Quaternary structure-dependent idiotope and antigen binding of a monoclonal antibody specific for conformational epitope on type II collagen (1997) (8)
- Preparation and properties of a lysozyme derivative in which two domains are cross-linked intramolecularly between Trp62 and Asp101. (1991) (8)
- Laser-assisted field-desorption mass spectrometry of cyclomalto-hexaose and -heptaose and some 6-alkylthio derivatives (1982) (8)
- Reaction of hen egg-white lysozyme with tetranitromethane: a new side reaction, oxidative bond cleavage at glycine 104, and sequential nitration of three tyrosine residues. (1990) (8)
- Resolution and structural determination of unsymmetrically 6A6D-disubstituted .beta.-cyclodextrin (1985) (8)
- Peptide separation by reversed-phase high-performance liquid chromatography (2004) (7)
- Complete sets of structurally determined 6A,6X-unsymmetrically disubstituted .beta.-cyclodextrins. 6A-S-phenyl-6X-O-(.beta.-naphthylsulfonyl)-6A-thio-.beta.-cyclodextrins and 6A-S-(tert-butyl)-6X-O-(.beta.-naphthylsulfonyl)-6A-thio-.beta.-cyclodextrins (1988) (7)
- Analysis of the stability of mutant lysozymes at position 15 using X-ray crystallography. (1997) (7)
- Effects of additives on irreversible inactivation of lysozyme at neutral pH and 100 degrees C. (1995) (7)
- Kinetically trapped structure in the renaturation of reduced oxindolealanine 62 lysozyme. (1995) (7)
- A single amino acid substitution in a self protein is sufficient to trigger autoantibody response. (2001) (7)
- Modifications of stability and function of lysozyme (1987) (6)
- Polymeric inclusion compound derived from .beta.-cyclodextrin (1982) (6)
- Construction of the single-chain Fv from 196-14 antibody toward ovarian cancer-associated antigen CA125. (1999) (6)
- Regiospecifically Bifunctional Cyclodextrins Having Two Amino Groups on Secondary Hydroxyl Side (1989) (6)
- Specific carbodiimide-binding mechanism for the selective modification of the aspartic acid-101 residue of lysozyme in the carbodiimide-amine reaction. (1986) (6)
- Straightforward Preparation and Stabilization of 2-trans-4,7: 10,13-Diepoxy[15]annulenone (1983) (6)
- Analysis of a catalytic pathway via a covalent adduct of D52E hen egg white mutant lysozyme by further mutation. (1999) (6)
- A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain. (1982) (6)
- Specificity of trypsin. Cleavage of aspartic acid 101 derivatives of lysozyme by trypsin. (1982) (6)
- Flavonoids in the Flowers of Gnaphalium affine D. Don (1975) (5)
- Meta/para-selectivity variation by sulfide/sulfoxide conversion of 6-substituted β-cyclodextrin. Hydrolyses of nitrophenyl acetates. ag (1984) (5)
- Identification of residue 103 in hen egg-white lysozyme. (1981) (5)
- Fluctuations in free or substrate-complexed lysozyme and a mutant of it detected on x-ray crystallography and comparison with those detected on NMR. (2002) (5)
- Enzymatic Preparation of Specifically Modified Linear Maltooligosaccharides through Taka-amylase A-catalyzed Hydrolysis of 6-O-Arenesulfonyl-γ-cyclodextrins (1988) (5)
- Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme* (2016) (5)
- Chitin Coated Cellulose as an Adsorbent of Lysozyme-like Enzymes: Some Applications (1973) (5)
- Synthesis of an [18]Annulene Dioxide: An Oxygen-Bridged [18]Annulene Possessing Equivalent Kekulé Structures (1983) (5)
- Novel rearrangement of twisted 2,4-di-alkyl 2-trans-4-trans pentadienals: An approach to cyclopentenones based on molecular mechanical consideration (1979) (5)
- Straightforward Preparation and Ground State Stabilization of 2-trans-4,7:10,13-Diepoxy[15] annulenone (1983) (5)
- Analysis of the transition state in the unfolding of hen lysozyme by introduction of Gly-Pro and Pro-Gly sequences at the same site. (1996) (5)
- Evidence for a novel racemization process of an asparaginyl residue in mouse lysozyme under physiological conditions (2004) (5)
- STRUCTURE OF MURAMIDASE (LYSOZYME). IV. EFFECTS OF ETHYLENE GLYCOL, POLYETHYLENE GLYCOL AND SUCROSE ON THE PHYSICO-CHEMICAL AND ENZYMATIC PROPERTIES OF MURAMIDASE. (1964) (5)
- On the Drift Speed of Floating Bodies In Waves (2002) (5)
- A new electrophoretic variant of hemoglobin (Munakata) in which a lysine residue is replaced by a methionine residue at position 90 of the alpha-chain. (1983) (4)
- The role of tryptophan-62 in the enzymic reaction of lysozyme. (1974) (4)
- B‐cell repertoire specific for an unfolded self‐determinant of mouse lysozyme escape tolerance and dominantly participate in the autoantibody response (2002) (4)
- Effects of Detergents or Fatty Acids on Proteolysis of Lysozymes (1980) (4)
- Analysis of internal motions of interleukin-13 variant associated with severe bronchial asthma using (15)N NMR relaxation measurements. (2007) (4)
- Rat cathepsin H-catalyzed transacylation: comparisons of the mechanism and the specificity with papain-superfamily proteases. (1991) (4)
- Regiochemical Correlation between 6-O-Sulfonylated Cyclodextrins and 3-O-Sulfonylated Cyclodextrins via 3,6-Anhydrocyclodextrins (1988) (4)
- Crystallization of the lysozyme-product complex. (1968) (4)
- Effects of stereochemistry of sugars on protein stabilities. (2002) (4)
- Synthesis and properties of a mercapto[15]annulenone: a 14π diatropic annulene triply characterised by a fast chemical exchange, tautomerisation, and cis-trans-isomerisation (1989) (3)
- Synthesis and structure determination of 3A,6X-Di-O-arenesulfonyl-∝-cyclodextrins (1989) (3)
- Mechanisms of a conversion from membrane associated lysosomal acid phosphatase to content forms. (1991) (3)
- Effect of W62G mutation of hen lysozyme on the folding in vivo. (2005) (3)
- pH dependence of individual tryptophan N-1 hydrogen exchange rates in lysozyme and its chemically modified derivatives. (1987) (3)
- Effect of sucrose on formation of the beta-amyloid fibrils and D-aspartic acids in Abeta 1-42. (2002) (3)
- Thermostability of doubly glycosylated recombinant lysozyme. (2001) (3)
- Unsymmetrically Disubstituted β-Cyclodextrins. 6A,6X-Dideoxy-6A-azido- 6X-[(mesitylsulfonyl)oxy] Derivatives. (1986) (3)
- Crystal structures of K33 mutant hen lysozymes with enhanced activities. (2008) (3)
- Favourable interaction between heavy and light chains arrests the undesirable oligomerization of heavy chains in the refolding of denatured and reduced immunoglobulin G (1997) (3)
- [Enjoying research on lysozymes for 42 years]. (2003) (3)
- THE ENZYME-SUBSTRATE COMPLEX IN A MURAMIDASE (LYSOZYME) CATALYZED REACTION. (1964) (3)
- Letter to the Editor: Assignment of 1H and 15N resonances of mouse lysozyme M (2000) (2)
- Preparation of oxygen-bridged aza[15]- and aza[17]annulene dicarboxylates by intramolecular azide cyclization (1988) (2)
- A simple methodology for aza-annulene synthesis: preparation and propreties of 2,15-diethoxycarbonyl-4,7:10,13-diepoxy-2-cis,8-cis, 14-cis-aza[15]annulene (1984) (2)
- Diepoxy[15]annulenones undergo photochemical carbonyl-O/divinyl ether-O transportation rearrangements: mechanistic probing of the rearrangement sequences facilitated by 13C/17O NMR spectroscopy (1995) (2)
- Analyses of Native Disulfide Bond Formations in the Early Stage of the Folding Process in Mutant Lysozymes Where the Long-Range Interactions in the Denatured State Were Modulated (2007) (2)
- An improved method for preparing lysozyme with chemically 13C-enriched methionine residues using 2-aminothiophenol as a reagent of thiolysis. (1997) (2)
- Interglucosyl Attack of Hydroxyl Group to Epoxy Ring of 2A,3A-Anhydro-(2AS)-α-cyclodextrin. Selective Preparation of 3A,2B-Anhydro-α-cyclodextrin (1989) (2)
- Reduction of disulfide bonds in proteins by 2-aminothiophenol under weakly acidic conditions. (1994) (2)
- Detection of a local interaction of hen lysozyme under highly denaturing conditions using chemically 13C-enriched methionine resonance. (1998) (2)
- [Foundation of the bases for protein research and its application to the pharmaceutical science field]. (2002) (2)
- 4:7,10:13-Diepoxy-1-aza[16]annulene and 3:6,9:12,15:18-triepoxy-2-chloro-1-aza-[18]annulene as the first examples of oxygen-bridged aza-[4n]- and -[4n+ 2]annulenes (1987) (2)
- Effect of protein concentration and pH on the chitinase activity of Tapes japonica lysozyme. (2010) (2)
- Highly controlled carbodiimide reaction for the modification of lysozyme. Modification of Leu129 or Asp119. (1987) (2)
- A study of the native-denatured (N in equilibrium with D) transition in lysozyme. II. Kinetic analysis of protease digestion. (1976) (2)
- A complete set of 3A,6X-di-O-sulfonylated α-cyclodextrins (1992) (2)
- Characterization of Refolded Hen Lysozyme Variant Lacking Two Outside Disulfide Bonds (2005) (2)
- Proteolysis of lysozyme-substrate complex (1969) (2)
- Correlation between the differences in the free energy change and conformational energy in the folded state of hen lysozymes with Gly-Pro and Pro-Gly sequences introduced to the same site. (1995) (2)
- 6A6B-, 6A6C-, AND 6A6D-DISULFONATES OF α-CYCLODEXTRIN (1985) (2)
- Hemoglobin J Lome: β59 (E3) Lysine → Asparagine Observed in a Japanese Family (1983) (1)
- 6-O-Trisubstituted β-Cyclodextrins Whose Substituents Are Different from One Another (1988) (1)
- 4:7,10:13-diepoxy[15]annulenones exchange their oxygen bridges on irradiation : 17O NMR spectroscopic and chemical verification of the exchanges (1991) (1)
- Crystal Structure of Tapes japonica Lysozyme (2007) (1)
- The synthesis of an oxygen-bridged hydroxy[15]annulenone: the effects of introducing one hydroxy group into the flexible segment of a 14π perimeter (1989) (1)
- Effective protein folding in simple random search. (2001) (1)
- [Establishment of fundamentals for protein research. Stabilization of protein]. (1996) (1)
- Reactivities of various amines in the modifications of acetic acid and aspartic acid-101 of lysozyme in the carbodiimide reaction. (1987) (1)
- 1H-NMR study of the intramolecular interaction of a substrate analogue covalently attached to aspartic acid-101 in lysozyme. (1991) (1)
- Formulation of a Universal First-Order Rate Constant for Enzymatic Reactions (2013) (1)
- Influence of mutations of the N-cap residue, Gly4, on stability and structure of hen lysozyme. (1997) (1)
- α/β-Selectivity in Hydrolyses of α- or β- Naphthyl Acetates in the Presence of Cycloamyloses. (1984) (1)
- Construction of a screening system for selecting lysozyme mutants unable to form a stable structure from random mutants. (1999) (1)
- Expression of human IL-13 receptor α2 extracellular domain in Pichia pastoris (2007) (1)
- Effects of Detergents on Lysis of Micrococcus lysodeikticus by Lysozyme (1983) (1)
- A metal binding in the polypeptide chain improves the folding efficiency of a denatured and reduced protein. (2002) (0)
- NOVEL REARRANGEMENT OF TWISTED 2,4-DIALKYL2-TRANS,4-TRANS-PENTADIENALS: AN APPROACH TO CYCLOPENTENONES BASED ON MOLECULAR MECHANICAL CONSIDERATION (1980) (0)
- Synthesis and Properties of a Mercapto(15)annulenone: A 14π Diatropic Annulene Triply Characterized by a Fast Chemical Exchange, Tautomerization, and cis-trans-Isomerization. (1989) (0)
- Solution structure of mouse lysozyme M (2002) (0)
- Structural Study of Monosubstituted β‐Cyclodextrins. Crystal Structures of Phenylthio‐β‐cyclodextrin and Phenylsulfinyl‐β‐cyclodextrin and Spectroscopic Study of Related Compounds in Aqueous Solution. (1987) (0)
- Hemoglobin Hofu: beta 126 (H4) valine----glutamic acid observed in a Japanese family. (1984) (0)
- Chemical Similarities of Di-oxa[15]annulenone Cycle with Bacteriorhodopsin Cycle (1985) (0)
- Global fluctutations of protein under physiological conditions. (1993) (0)
- HEN EGG WHITE LYSOZYME MUTANT WITH ALANINE SUBSTITUTED FOR GLYCINE (2000) (0)
- [Protein engineering of lysozyme]. (1994) (0)
- Preparation de proteines (2002) (0)
- Construction of an Annulene Cycle Driven by Protonation-Deprotonation Sequence: A Property of an Annulene-cycles as a Model of Proton Pump Cycle of Bacteriorhodospin (1982) (0)
- Establishment of Fundamentals for Protein Research. Stabilization of Protein (1996) (0)
- Chemical Modification of Bacteriorhodopsin: Remarkable Red Shifts of Pyrrole Polyenal Protonated Schiff Bases and Reconstruction of a Bacteriorhodopsin Analog by the Use of a Pyrrole Polyenal (1986) (0)
- A [15]Annulenone-[15]annulenyl Ion Cycle Driven by Proton Gradient (1980) (0)
- Synthesis of an Oxygen-Bridged Hydroxy(15)annulenone: The Effects of Introducing One Hydroxy Group into the Flexible Segment of a 14π Perimeter. (1989) (0)
- SYNTHESIS OF HETERO(17)ANNULENE DIOXIDES AND A (16)ANNULENE DIOXIDE USING FURAN AS A BUILDING BLOCK (1983) (0)
- Hetero[17]annulene Dioxides and [16]Annulene Dioxide Prepared by Using Furan as Building Blocks (1983) (0)
- Diepoxy(15)annulenones Undergo Photochemical Carbonyl‐O/Divinyl Ether‐ O Transportation Rearrangements: Mechanistic Probing of the Rearrangement Sequences Facilitated by 13C/17O NMR Spectroscopy. (1995) (0)
- DIRECT PREPARATION AND STABILIZATION OF 2-TRANS-4,7:10,13-DIEPOXY(15)ANNULENONE (1983) (0)
- Biological product system. For the future. Development of protein engineering. (1997) (0)
- Synthesis of Oxygen-bridged Aza[15]annulene Derivatives. Novel Cyclization Reaction Leading to Aza-annulene Frames (1984) (0)
- Enjoying Research on Lysozymes for 42 Years (2003) (0)
- Foundation of the Bases for Protein Research and Its Application to the Pharmaceutical Science Field (2002) (0)
- Synthesis of Oxygen‐Bridged Aza[15]annulene Derivatives. Novel Cyclization Reaction Leading to Aza‐Annulene Frames. (1984) (0)
- Synthesis of Hetero[17]annulene Dioxides and a [16]Annulene Dioxide Using Furan Building Blocks (1983) (0)
- Chemical Modifications of Di-oxa[15]annulenone (1985) (0)
- α/β-SELECTIVITY IN HYDROLYSES OF α- OR β-NAPHTHYL ACETATES IN THE PRESENCE OF CYCLOAMYLOSES (1984) (0)
- Crystal Structure of hen egg white lysozyme mutant N46D/D52S (2015) (0)
- Response Lysozyme Evokes High Autoantibody Minimal T Cell Epitope of Hen Egg Mutant Mouse Lysozyme Carrying a (2000) (0)
- The Photochemistry of Annulenyl-Ion/Annulenone Cycle as a Model of Bacteriorhodopsin. (1983) (0)
- Inputting information about amino acid residues in protein bioinformatics: a case study on predicting helical regions with a neural network. (2006) (0)
- Enzyme-Based Discrimination between Clockwise and Counterclockwise Isomers of Unsymmetrically Disubstituted β-Cyclodextrins. (1986) (0)
- Synthesis of Specifically Modified Maltooligosaccharides by Enzymatic Degradation of Cyclodextrin Derivatives. Substrate-Based Investigation of the Active Site of Taka-Amylase. (1987) (0)
- [Folding of protein (lysozyme)]. (2003) (0)
- IM mutant of lysozyme (2001) (0)
- A SIMPLE METHODOLOGY FOR AZAANNULENE SYNTHESIS: PREPARATION AND PROPERTIES OF 2,15-DIETHOXYCARBONYL-4,7:10,13-DIEPOXY-2-CIS,8-CIS,14-CIS-AZA(15)ANNULENE (1984) (0)
- Trinitrobenzene Sulfonic Acid (2002) (0)
- Guest-Induced Conformational Change of 6-Monosubstituted Cyclodextrin (1983) (0)
- Analysis of internal motions of RNase T1 complexed with a productive substrate involving 15N NMR relaxation measurements. (2006) (0)
- Additivity of lytic activities for mutant lysozymes (1997) (0)
- SYNTHESIS OF A DIOXYGEN BRIDGED (18)ANNULENE: A NEW EXAMPLE OF STRONGLY DIATROPIC (18)ANNULENE WITH A TWISTED PERIMETER (1983) (0)
- High Salinity Waters Found off the Kii Peninsula (1997) (0)
- Unfolding Limit the Immunogenicity of That Free-Energy Barriers for Protein Immunologically Dominant Factor : Evidence A Protein ' s Conformational Stability (2010) (0)
- Is 3-Methyl[15]annulenone-Hydroxy-3-methyl[15]annulenylium Ion Cycle Mimic to Bacteriorhodospin Cycle? (1984) (0)
- Derivation of a valid momentary first-order rate constant for kinetic and energetic analyses of enzymatic reactions. (2016) (0)
- Hemoglobin J Lome: beta 59 (E3) lysine replaced by asparagine observed in a Japanese family. (1983) (0)
- Preparation of Oxygen-Bridged Aza(15)- (VII) and Aza(17)annulene (XI) Dicarboxylates by Intramolecular Azide Cyclization. (1988) (0)
- The three dimensional structure of all-cis-diepoxy[15]annulenone and some implications from the structure (1989) (0)
- Activation of the Epitope-Specific T Cells Region of a Cryptic Self-Determinant Leads Insertion of the Dibasic Motif in the Flanking Moudgil (2005) (0)
- The Involvement of the Residual Structure Containing Long-Range Interactions on the Denatured State of a Protein in the Amyloid Fibrils Formation (2008) (0)
- Photocyclic processes of an oxygen-bridged [15]annulenyl ion, whose state-to-state changes are very similar to those of bacteriorhodopsin (1991) (0)
- Protei enginnering of lysozyme. (1989) (0)
- RESOLUTION AND STRUCTURAL DETERMINATION OF UNSYMMETRICALLY 6A6D-DISUBSTITUTED β-CYCLODEXTRIN (1985) (0)
- Chemical Transformation of 4:7,10:13-Diepoxy[15]annulenone by Carbonyl Transposition Reactions. (1986) (0)
- Chemical transformations of 4:7,10:13-diepoxy[15]annulenone by carbonyl transposition reactions (1985) (0)
- A Simple Synthesis of Aza[15]annulenes. (1985) (0)
- SYNTHESIS OF AN (18)ANNULENE DIOXIDE: AN OXYGEN-BRIDGED (18)ANNULENE WITH EQUIVALENT KEKULE STRUCTURES (1983) (0)
- Construction of a [15]Annulenone-[15]annulenyl Ion Cycle (1981) (0)
- Expression of human IL-13 receptor alpha2 extracellular domain in Pichia pastoris. (2007) (0)
- Resolution and Characterization of Hen Egg-White Lysozyme byof Tryptophyl Fluorescence Quenching-and Time-ResolvedSpectroscopy (2018) (0)
- Regiospecific sulfonation onto C-3 Hydroxyls of β-Cyclodextrin. (1986) (0)
- [Modification of lysozyme]. (1992) (0)
- Oxygen-bridged Thia[15]annulenes: Demonstration of a Strong Paramagnetic Ring Current in a 4np-Thia-annulene (n=4) (1982) (0)
- 4:7,10:13-Diepoxy-1-aza(16)annulene and 3:6,9:12,15:18-Triepoxy-2-chloro-1-aza(18)annulene as the First Examples of Oxygen-Bridged Aza-(4n)- and -(4n+2)-annulenes. (1987) (0)
- Synthesis of 6A,6X-Di-O-(p-tosyl)-γ-cyclodextrins and Their Structural Determination Through Enzymatic Hydrolysis of 3A,6A;3X,6X-Dianhydro-γcyclodextrins. (1988) (0)
- Water-soluble carrier proteins having carboxyl spacer groups. (1985) (0)
- Heterobifunctional reagents for cross-linking of sugar with protein. (1985) (0)
- ANALYSIS OF THE STABILIZATION OF HEN LYSOZYME WITH THE HELIX DIPOLE AND CHARGED SIDE CHAINS (1997) (0)
- Detection of subtle differences in the surface structure of lysozymes by use of an immobilized Fab fragment. (1993) (0)
- META/PARA-SELECTIVITY VARIATION BY SULFIDE-SULFOXIDE CONVERSION OF 6-SUBSTITUTED β-CYCLODEXTRIN. HYDROLYSES OF NITROPHENYL ACETATES (1985) (0)
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