Takashi Kadowaki

Q: What Schools Are Affiliated With Takashi Kadowaki

Takashi Kadowaki is affiliated with the following schools: Hokkaido University, Teikyo University, University of Tokyo, Showa University, Shiga University of Medical Science, Osaka University, University of the Witwatersrand, Kyoto University

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Takashi Kadowaki

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Takashi Kadowaki

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Philosophy
Biology
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Takashi Kadowaki's Degrees

PhD Biochemistry University of Tokyo
Doctorate Medicine University of Tokyo

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Takashi Kadowaki's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity (2001) (4863)
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase (2002) (4166)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003) (3033)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. (2006) (2634)
Adiponectin and adiponectin receptors. (2005) (2563)
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity (2009) (1980)
Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus (2010) (1938)
Diabetes in Asia: epidemiology, risk factors, and pathophysiology. (2009) (1869)
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation* (2002) (1382)
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance (1999) (1243)
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007) (1239)
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 (1994) (1071)
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes (2003) (994)
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. (1998) (985)
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. (2001) (962)
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006) (946)
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis* (2003) (945)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance* (2006) (867)
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. (2004) (834)
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 (2010) (821)
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. (2007) (776)
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus (2008) (739)
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations (2008) (717)
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (2002) (714)
Cardiovascular Disease and Risk Factors in Asia: A Selected Review (2008) (627)
PI3K-mediated negative feedback regulation of IL-12 production in DCs (2002) (609)
The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance* (2001) (593)
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians (2011) (581)
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. (2002) (566)
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. (1994) (560)
A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen (2002) (539)
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity (2013) (539)
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. (1999) (536)
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. (2000) (532)
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. (2002) (511)
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. (1999) (510)
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. (2008) (473)
A liver-derived secretory protein, selenoprotein P, causes insulin resistance. (2010) (468)
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. (1999) (456)
Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels (2007) (453)
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. (2012) (445)
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. (2005) (431)
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase (1999) (428)
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling (2002) (395)
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. (2011) (386)
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity* (2004) (384)
Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis* (1998) (380)
Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPARα, PPARγ, and Their Combination (2005) (369)
Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis* (2005) (336)
Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. (2013) (331)
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. (2007) (329)
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways* (2006) (322)
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases (2008) (319)
Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. (2005) (318)
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes. (1993) (313)
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone (1997) (307)
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins. (1986) (306)
Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways (2006) (295)
Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. (1988) (289)
Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade (2003) (287)
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice (1996) (286)
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. (2001) (284)
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. (2001) (282)
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS (2008) (277)
Adiponectin receptors: a review of their structure, function and how they work. (2014) (275)
Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44 and p42(*) (1995) (266)
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. (1998) (264)
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. (2000) (264)
The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes (2000) (264)
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B (2010) (261)
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients (2008) (261)
Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet (2002) (260)
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. (2008) (259)
Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. (1994) (255)
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. (2011) (255)
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. (2001) (253)
Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial (2019) (251)
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. (2002) (249)
Insights into insulin resistance and type 2 diabetes from knockout mouse models. (2000) (249)
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes (2002) (242)
Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo (2002) (241)
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. (2004) (240)
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. (1998) (238)
Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study. (2008) (231)
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. (2005) (229)
A cross-population atlas of genetic associations for 220 human phenotypes (2021) (229)
Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling (2007) (225)
Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. (1984) (224)
Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients (1990) (222)
Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. (2007) (222)
A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site. (2013) (220)
Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury (2001) (218)
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. (2008) (216)
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population (2007) (213)
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice (2002) (210)
Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease (2009) (207)
Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice. (2003) (205)
Association Between Plasma Triglycerides and High-Density Lipoprotein Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes Mellitus: A Global Case–Control Study in 13 Countries (2013) (203)
Molecular Mechanism of Insulin Resistance and Obesity (2003) (202)
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. (2005) (200)
Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation (2001) (198)
Angiopoietin-related growth factor antagonizes obesity and insulin resistance (2005) (198)
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation. (2013) (196)
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases (2020) (191)
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. (2003) (189)
Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase* (1998) (189)
Identification of type 2 diabetes loci in 433,540 East Asian individuals (2019) (188)
Cigarette Smoking as a Risk Factor for Stroke Death in Japan NIPPON DATA80 (2004) (188)
Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial. (2017) (186)
Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice. (2006) (184)
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease (2017) (179)
Cognitive impairment as a strong predictor of incident disability in specific ADL-IADL tasks among community-dwelling elders: the Azuchi Study. (2005) (179)
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. (1990) (178)
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition (2008) (178)
Peroxisome Proliferator-Activated Receptor Gamma Agonist Ligands Stimulate a Th2 Cytokine Response and Prevent Acute Colitis (2002) (176)
Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. (1999) (173)
Risk factors for worsening to diabetes in subjects with impaired glucose tolerance (2004) (172)
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India (2013) (168)
Involvement of p85 in p53-dependent apoptotic response to oxidative stress (1998) (167)
IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs (2015) (167)
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. (2009) (166)
Crystal structures of the human adiponectin receptors (2015) (165)
Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy* (1999) (162)
The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort. (2007) (160)
A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. (2006) (160)
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. (1992) (158)
Alcohol consumption and other risk factors for self‐reported diabetes among middle‐aged Japanese: a population‐based prospective study in the JPHC study cohort I (2005) (158)
DialBetics: A Novel Smartphone-based Self-management Support System for Type 2 Diabetes Patients. (2014) (158)
Residual macrovascular risk in 2013: what have we learned? (2014) (157)
Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. (2003) (156)
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction (2003) (155)
Expression of adiponectin receptors and its possible implication in the human endometrium. (2006) (155)
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population (2007) (153)
Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. (1987) (152)
Trial of Insulinlike Growth Factor I Therapy for Patients With Extreme Insulin Resistance Syndromes (1993) (152)
Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells. (1999) (152)
Selective purification and characterization of adiponectin multimer species from human plasma. (2007) (151)
Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. (2004) (150)
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice (2002) (149)
Genome-wide association study identifies three novel loci for type 2 diabetes. (2014) (149)
Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. (1999) (149)
Peroxisome Proliferator-activated Receptor γ-mediated Regulation of Neural Stem Cell Proliferation and Differentiation* (2006) (146)
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity (2011) (146)
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. (2003) (145)
Less subclinical atherosclerosis in Japanese men in Japan than in White men in the United States in the post-World War II birth cohort. (2007) (145)
Usefulness of measuring both body mass index and waist circumference for the estimation of visceral adiposity and related cardiometabolic risk profile (from the INSPIRE ME IAA study). (2015) (144)
Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor gamma 2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men. (1998) (140)
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. (1997) (140)
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts (2002) (139)
A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction. (1990) (139)
Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver* (2001) (138)
Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. (2002) (137)
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes (2012) (137)
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes (2016) (136)
What cause of mortality can we predict by cholesterol screening in the Japanese general population? (2003) (136)
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2 (2007) (136)
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity (2005) (135)
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. (2002) (134)
Cell Type–Specific Angiotensin II–Evoked Signal Transduction Pathways (1998) (134)
Annexin II Is a Novel Player in Insulin Signal Transduction (1996) (132)
Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration (2008) (130)
Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis. (2001) (129)
Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes. (1996) (126)
Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor γ* (2001) (126)
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ (2008) (125)
Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. (2010) (124)
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population (2019) (124)
Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit* (2010) (124)
Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes. (1997) (124)
p53 Involvement in the Pathogenesis of Fatty Liver Disease* (2004) (124)
Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells (2015) (123)
Adiponectin Regulates Cutaneous Wound Healing by Promoting Keratinocyte Proliferation and Migration via the ERK Signaling Pathway (2012) (122)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. (2006) (121)
PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. (2002) (121)
Psychological factors, coffee and risk of diabetes mellitus among middle-aged Japanese: a population-based prospective study in the JPHC study cohort. (2009) (119)
A mutation of the b3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride (1997) (118)
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. (1989) (118)
Global Mapping of Cell Type–Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation (2011) (118)
Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. (2004) (116)
Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians (2014) (116)
The inverse relationship between serum high-density lipoprotein cholesterol level and all-cause mortality in a 9.6-year follow-up study in the Japanese general population. (2006) (115)
Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice. (2016) (115)
Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors. (1986) (114)
Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials (2016) (113)
Maternally inherited diabetes and deafness: a new diabetes subtype (1996) (113)
Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study (2012) (113)
Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population. (2004) (112)
Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. (2005) (112)
Constitutive Tyrosine Phosphorylation of ErbB-2 via Jak2 by Autocrine Secretion of Prolactin in Human Breast Cancer* (2000) (111)
SREBP-1-independent regulation of lipogenic gene expression in adipocytes Published, JLR Papers in Press, April 24, 2007. (2007) (109)
Imbalanced Insulin Actions in Obesity and Type 2 Diabetes: Key Mouse Models of Insulin Signaling Pathway. (2017) (107)
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. (1989) (106)
Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors. (1994) (104)
Ethidium Bromide-induced Inhibition of Mitochondrial Gene Transcription Suppresses Glucose-stimulated Insulin Release in the Mouse Pancreatic β-Cell Line βHC9* (1998) (104)
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. (2000) (104)
Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages* (2008) (104)
Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. (2001) (104)
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. (2009) (104)
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (2012) (103)
Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. (2005) (103)
Upstream Mechanisms of Glycogen Synthase Activation by Insulin and Insulin-like Growth Factor-I (1995) (101)
Role of Insulin Receptor Substrate-1 and pp60 in the Regulation of Insulin-induced Glucose Transport and GLUT4 Translocation in Primary Adipocytes* (1997) (100)
Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p (2002) (100)
Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double‐blind trial (2010) (99)
Daytime Napping and the Risk of Cardiovascular Disease and All-Cause Mortality: A Prospective Study and Dose-Response Meta-Analysis. (2015) (98)
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4 (2013) (97)
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. (2010) (97)
Lack of Insulin Receptor Substrate‐2 Causes Progressive Neointima Formation in Response to Vessel Injury (2003) (96)
Variations of plantar thermographic patterns in normal controls and non-ulcer diabetic patients: novel classification using angiosome concept. (2011) (96)
Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80). (2004) (96)
Multiple Exocytotic Pathways in Pancreatic β Cells (1997) (96)
Association between fish consumption and all-cause and cause-specific mortality in Japan: NIPPON DATA80, 1980-99. (2005) (96)
Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet. (2004) (94)
Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects (2006) (93)
Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis (2009) (93)
The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis (2018) (92)
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects (2008) (92)
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. (2003) (92)
Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. (1999) (91)
Lower Levels of Serum Albumin and Total Cholesterol Associated with Decline in Activities of Daily Living and Excess Mortality in a 12‐Year Cohort Study of Elderly Japanese (2008) (89)
Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin. (2005) (89)
Effects of once‐daily teneligliptin on 24‐h blood glucose control and safety in Japanese patients with type 2 diabetes mellitus: a 4‐week, randomized, double‐blind, placebo‐controlled trial (2012) (88)
Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals (2012) (88)
Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan: NIPPON DATA90. (2006) (88)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation (2020) (88)
Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study (2006) (88)
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. (1994) (88)
Phosphatidylinositol 3-Kinase and NF-κB/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways (2000) (87)
Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites. (1990) (87)
Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A-G) mutation in Japanese: maternal inheritance and mitochondria-related complications. (2003) (87)
Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1 (*) (1995) (87)
Age-specific effects of systolic and diastolic blood pressures on mortality due to cardiovascular diseases among Japanese men (NIPPON DATA80*) (2006) (87)
Empagliflozin in Patients with Chronic Kidney Disease (2022) (86)
Mechanical Stretch Induces Hypertrophic Responses in Cardiac Myocytes of Angiotensin II Type 1a Receptor Knockout Mice* (1998) (86)
Nitration of PPARγ inhibits ligand‐dependent translocation into the nucleus in a macrophage‐like cell line, RAW 264 (2002) (86)
Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes. (1999) (85)
Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. (1993) (85)
The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages (2010) (85)
Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice. (2005) (85)
Distinct effects of PPARγ insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells (2005) (85)
NAD+ supplementation rejuvenates aged gut adult stem cells (2019) (85)
Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c. (2004) (85)
Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. (1987) (84)
Prediction of pregnancy rate by blastocyst morphological score and age, based on 1,488 single frozen-thawed blastocyst transfer cycles. (2011) (82)
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. (2012) (82)
Efficacy, safety and dose–response relationship of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, in Japanese patients with type 2 diabetes mellitus (2013) (81)
Phosphorylation of tubulin and microtubule-associated proteins by the purified insulin receptor kinase. (1985) (81)
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. (2004) (81)
Ghrelin improves renal function in mice with ischemic acute renal failure. (2005) (80)
Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study (2020) (80)
Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice. (1998) (80)
Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro. (1986) (80)
TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass (2014) (79)
Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription. (2002) (79)
Ethnic differences in insulin sensitivity, β-cell function, and hepatic extraction between Japanese and Caucasians: a minimal model analysis. (2014) (78)
The Gln27Glu beta2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. (1999) (77)
Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization (2013) (77)
Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice. (2005) (77)
KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. (2016) (77)
Signal transduction mechanism of insulin and insulin-like growth factor-1. (1996) (76)
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association (2009) (76)
Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice (2012) (76)
Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans (2005) (76)
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. (2005) (76)
Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue (2011) (75)
Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. (2002) (74)
Combined cardiovascular risk factors and outcome: NIPPON DATA80, 1980-1994. (2006) (74)
Expression of M-CSF receptor encoded by c-fms on smooth muscle cells derived from arteriosclerotic lesion. (1992) (73)
Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding. (1990) (73)
Mitochondrial gene mutation and insulin-deficient type of diabetes mellitus (1993) (73)
ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity (2014) (73)
A Prospective Study of Passive Smoking and Risk of Diabetes in a Cohort of Workers (2008) (72)
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. (2004) (72)
Erectile Dysfunction and Cardiovascular Events in Diabetic Men: A Meta-analysis of Observational Studies (2012) (72)
Alcohol consumption and risk of type 2 diabetes mellitus in Japanese: a systematic review. (2008) (71)
Empagliflozin Monotherapy in Japanese Patients with Type 2 Diabetes Mellitus: a Randomized, 12-Week, Double-Blind, Placebo-Controlled, Phase II Trial (2014) (71)
Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid. (2007) (71)
Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. (2011) (71)
Dietary restriction: standing up for sirtuins. (2010) (70)
Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol (2006) (70)
Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese (2011) (69)
Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain. (2011) (69)
A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. (1991) (67)
Impairment of Bone Healing by Insulin Receptor Substrate-1 Deficiency* (2004) (67)
Citrin/Mitochondrial Glycerol-3-phosphate Dehydrogenase Double Knock-out Mice Recapitulate Features of Human Citrin Deficiency* (2007) (66)
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca2+] elevation signals (2002) (66)
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease (2019) (65)
Aryl hydrocarbon receptor‐mediated effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin on glucose‐stimulated insulin secretion in mice (2009) (65)
Mechanism of amelioration of insulin resistance by beta3-adrenoceptor agonist AJ-9677 in the KK-Ay/Ta diabetic obese mouse model. (2001) (65)
Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic model. (2006) (65)
Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression. (1998) (64)
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. (2005) (63)
Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. (1991) (63)
Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States. (2009) (63)
Hypoxia and hypoxia/reoxygenation activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes. (1996) (63)
NADH Shuttle System Regulates KATPChannel-dependent Pathway and Steps Distal to Cytosolic Ca2+ Concentration Elevation in Glucose-induced Insulin Secretion* (1999) (63)
Adiponectin/adiponectin receptor in disease and aging (2015) (62)
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. (1998) (62)
A novel and selective sodium‐glucose cotransporter‐2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus (2015) (62)
SH2-containing Inositol Phosphatase 2 Predominantly Regulates Akt2, and Not Akt1, Phosphorylation at the Plasma Membrane in Response to Insulin in 3T3-L1 Adipocytes* (2004) (62)
BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells (2003) (62)
Fournier's gangrene caused by Candida species as the primary organism. (2000) (62)
Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation. (2006) (61)
Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice. (2008) (61)
Adiponectin receptor signaling: a new layer to the current model. (2011) (60)
Efficacy and safety of teneligliptin added to glimepiride in Japanese patients with type 2 diabetes mellitus: a randomized, double‐blind, placebo‐controlled study with an open‐label, long‐term extension (2014) (60)
Both Insulin Signaling Defects in the Liver and Obesity Contribute to Insulin Resistance and Cause Diabetes in Irs2–/– Mice* (2004) (60)
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy. (2000) (60)
Chewing Betel Quid and the Risk of Metabolic Disease, Cardiovascular Disease, and All-Cause Mortality: A Meta-Analysis (2013) (60)
A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism (1997) (60)
Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding. (1992) (60)
Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins (1996) (60)
Male pattern baldness and its association with coronary heart disease: a meta-analysis (2013) (59)
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection. (1992) (59)
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity (2016) (59)
The role of PPAR? in high-fat diet-induced obesity and insulin resistance (2002) (58)
Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion. (2002) (58)
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program (2017) (58)
Scavenger Receptor Expressed by Endothelial Cells I (SREC-I) Mediates the Uptake of Acetylated Low Density Lipoproteins by Macrophages Stimulated with Lipopolysaccharide* (2004) (58)
Association of Adenovirus 36 Infection with Obesity and Metabolic Markers in Humans: A Meta-Analysis of Observational Studies (2012) (57)
Ultrasonographic and thermographic screening for latent inflammation in diabetic foot callus. (2009) (57)
Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes. (2000) (57)
Expression of DGAT2 in White Adipose Tissue Is Regulated by Central Leptin Action* (2005) (57)
Sodium‐glucose co‐transporter‐2 inhibitors as add‐on therapy to insulin for type 1 diabetes mellitus: Systematic review and meta‐analysis of randomized controlled trials (2018) (56)
Substrates for Insulin-Receptor Kinase (1990) (56)
Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families? (2003) (56)
Vascular endothelial growth factor (VEGF) activates Raf‐1, mitogen‐activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes (1998) (56)
l-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2 (2015) (56)
Role of Insulin Resistance in MAFLD (2021) (56)
Adiponectin and adiponectin receptors in obesity-linked insulin resistance. (2007) (55)
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target (2017) (55)
Critical Role of Peroxisome Proliferator-Activated Receptor γ on Anoikis and Invasion of Squamous Cell Carcinoma (2005) (55)
Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells (2013) (54)
IRS‐2 branch of IGF‐1 receptor signaling is essential for appropriate timing of myelination (2008) (54)
Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study (2013) (54)
Exenatide exhibits dose-dependent effects on glycemic control over 12 weeks in Japanese patients with suboptimally controlled type 2 diabetes. (2009) (54)
Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARγ-dependent nongenomic signaling. (2011) (54)
Much lower prevalence of coronary calcium detected by electron-beam computed tomography among men aged 40-49 in Japan than in the US, despite a less favorable profile of major risk factors. (2004) (54)
Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes. (2015) (54)
Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80. (2014) (54)
Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians (2014) (54)
Rimonabant Ameliorates Insulin Resistance via both Adiponectin-dependent and Adiponectin-independent Pathways* (2009) (53)
Chlorpropamide-induced Hyponatremia: Incidence and Risk Factors (1983) (53)
Free supernumerary kidney: a case report and review. (1981) (52)
Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity (2015) (52)
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (2010) (52)
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese (2014) (52)
Changes in Weight, cardiovascular risk factors and estimated risk of coronary heart disease following smoking cessation in Japanese male workers: HIPOP-OHP study. (2010) (52)
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice. (2010) (51)
Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney (2017) (51)
Efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus (2013) (51)
Teneligliptin for the treatment of type 2 diabetes. (2013) (51)
RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA (2004) (51)
Coronary artery calcification in Japanese men in Japan and Hawaii. (2007) (51)
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes (2001) (51)
A “natural experiment” in cardiovascular epidemiology in the early 21st century (2003) (51)
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity (2018) (51)
Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass. (2009) (50)
Hypoxia induces activation and subcellular translocation of focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. (1999) (50)
Combating diabetes and obesity in Japan (2006) (50)
Improved glycemic control and reduced bodyweight with exenatide: A double‐blind, randomized, phase 3 study in Japanese patients with suboptimally controlled type 2 diabetes over 24 weeks (2010) (50)
Tyrosine phosphorylation by the epidermal growth factor receptor kinase induces functional alterations in microtubule-associated protein 2. (1987) (50)
Empagliflozin and kidney outcomes in Asian patients with type 2 diabetes and established cardiovascular disease: Results from the EMPA‐REG OUTCOME® trial (2019) (49)
A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. (2006) (49)
The Proportion of Individuals with Alcohol-Induced Hypertension among Total Hypertensives in a General Japanese Population: NIPPON DATA90 (2007) (49)
Sex differences in the pharmacokinetics of pioglitazone in rats. (2003) (49)
Genetic basis of endocrine disease. 1. Molecular genetics of insulin resistant diabetes mellitus. (1991) (49)
IL-1[alpha] induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs (2015) (49)
Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol-3-phosphate dehydrogenase gene. (2003) (49)
γ-Glutamyltransferase predicts cardiovascular death among Japanese women (2007) (48)
Prevalence of diabetes estimated by plasma glucose criteria combined with standardized measurement of HbA1c among health checkup participants on Miyako Island, Japan. (2000) (48)
Development of a hand-held personal digital assistant-based food diary with food photographs for Japanese subjects. (2009) (47)
[Molecular mechanism of insulin resistance]. (2005) (47)
A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (2000) (47)
5‐Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue (2008) (47)
A qualitative study on the impact of internalized stigma on type 2 diabetes self-management. (2016) (47)
Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice. (2020) (47)
Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. (2004) (47)
Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise. (2009) (47)
A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice* (2015) (47)
The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian. (1990) (46)
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals. (2002) (46)
Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance (2014) (46)
Substitution at Pro385 of GLUT1 perturbs the glucose transport function by reducing conformational flexibility. (1994) (46)
Adrenomedullin augments collateral development in response to acute ischemia. (2003) (46)
Two Patients With Insulin Resistance Due to Decreased Levels of Insulin-Receptor mRNA (1991) (46)
Polymorphism of the angiotensin converting enzyme gene and blood pressure in a Japanese general population (the Shigaraki Study). (2002) (46)
New glycemic targets for patients with diabetes from the Japan Diabetes Society (2016) (45)
Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic β-cells (2003) (45)
Hepatic safety profile and glycemic control of pioglitazone in more than 20,000 patients with type 2 diabetes mellitus: postmarketing surveillance study in Japan. (2007) (45)
The High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study: study design and cardiovascular risk factors at the baseline survey (2004) (45)
Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80 (2008) (45)
Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP study. (2010) (45)
Efficacy and Safety of Empagliflozin Monotherapy for 52 Weeks in Japanese Patients with Type 2 Diabetes: A Randomized, Double-Blind, Parallel-Group Study (2015) (45)
Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet. (2011) (45)
Addition of sitagliptin to ongoing glimepiride therapy in Japanese patients with type 2 diabetes over 52 weeks leads to improved glycemic control (2011) (44)
Effectiveness of a Low‐Intensity Intra‐Worksite Intervention on Smoking Cessation in Japanese Employees: A Three‐Year Intervention Trial (2006) (44)
Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides. (2004) (44)
Morphological Pattern Classification System for Plantar Thermography of Patients with Diabetes (2013) (44)
Two-photon excitation imaging of pancreatic islets with various fluorescent probes. (2002) (44)
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice (1998) (44)
Preparation and culture of bone marrow-derived macrophages from mice for functional analysis (2020) (44)
J-curve relation between daytime nap duration and type 2 diabetes or metabolic syndrome: A dose-response meta-analysis (2016) (43)
Safety and efficacy of teneligliptin in Japanese patients with type 2 diabetes mellitus: a pooled analysis of two Phase III clinical studies (2015) (43)
Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study. (2016) (43)
Crucial role of insulin receptor substrate‐2 in compensatory β‐cell hyperplasia in response to high fat diet–induced insulin resistance (2008) (43)
Efficacy and safety of canagliflozin as add‐on therapy to teneligliptin in Japanese patients with type 2 diabetes mellitus: Results of a 24‐week, randomized, double‐blind, placebo‐controlled trial (2017) (43)
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance (2011) (43)
Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding (2016) (43)
Associations of obesity measures with metabolic risk factors in a community-based population in Japan. (2007) (43)
Hemoglobin A1c (HbA1c) predicts future drug treatment for diabetes mellitus: a follow-up study using routine clinical data in a Japanese university hospital. (2007) (43)
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes (2005) (43)
Relation of Adult Height With Stroke Mortality in Japan NIPPON DATA80 (2007) (43)
Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus. (1994) (43)
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes. (2000) (42)
DialBetics With a Multimedia Food Recording Tool, FoodLog (2015) (42)
Substitution of arginine for histidine at position 209 in the alpha-subunit of the human insulin receptor. A mutation that impairs receptor dimerization and transport of receptors to the cell surface. (1991) (42)
Genetic architecture of type 2 diabetes. (2014) (42)
SnapShot: Insulin Signaling Pathways (2012) (42)
Insulin and platelet-derived growth factor stimulate phosphorylation of the c-raf product at serine and threonine residues in intact cells. (1991) (42)
The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family. (1999) (42)
Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. (2009) (41)
Effectiveness of lifestyle counseling by certified expert nurse of Japan for non-insulin-treated diabetic outpatients: a 1-year randomized controlled trial. (2007) (41)
A subtype of diabetes mellitus associated with a mutation in the mitochondrial gene (1995) (41)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism (2019) (41)
Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance (2012) (41)
Structural and functional analysis of the insulin receptor promoter. (1990) (41)
Differential Association of Docosahexaenoic and Eicosapentaenoic Acids With Carotid Intima-Media Thickness (2011) (41)
Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus. (1992) (40)
Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-beta. (1988) (40)
Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain. (1992) (40)
Adiponectin and its receptors: implications for obesity-associated diseases and longevity. (2014) (40)
A Japanese diet and 19-year mortality: National Integrated Project for Prospective Observation of Non-Communicable Diseases and its Trends in the Aged, 1980 (2008) (40)
Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study (2014) (40)
High hemoglobin A1c levels within the non‐diabetic range are associated with the risk of all cancers (2015) (39)
Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion (2014) (39)
Non-invasive measurement of brachial-ankle pulse wave velocity is associated with serum C-reactive protein but not with alpha-tocopherol in Japanese middle-aged male workers. (2004) (39)
The Oscillatory Behavior of Pancreatic Islets from Mice with Mitochondrial Glycerol-3-phosphate Dehydrogenase Knockout* (2000) (39)
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver Published, JLR Papers in Press, June 1, 2006. (2006) (39)
Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion. (1999) (39)
Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population. (2016) (38)
Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension (2010) (38)
Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists. (2001) (38)
Life Expectancy among Japanese of Different Smoking Status in Japan: NIPPON DATA80 (2007) (38)
World Health Organization-defined metabolic syndrome is a better predictor of coronary calcium than the adult treatment panel III criteria in American men aged 40-49 years. (2004) (38)
Sequence Variations of the Glucokinase Gene in Japanese Subjects With NIDDM (1993) (38)
Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population (2006) (37)
Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial. (2022) (37)
Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study - suggestion for the threshold for impaired fasting glucose among Japanese. (2010) (37)
Visceral and Subcutaneous Adiposity and Adiponectin in Middle‐aged Japanese Men: The ERA JUMP Study (2009) (37)
Coffee consumption and risk of type 2 diabetes mellitus. Authors' reply (2003) (37)
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes (2007) (37)
The role of the NPXY motif in the insulin receptor in tyrosine phosphorylation of insulin receptor substrate-1 and Shc. (1995) (37)
Association between self-stigma and self-care behaviors in patients with type 2 diabetes: a cross-sectional study (2016) (37)
Class IA phosphatidylinositol 3‐kinase regulates osteoclastic bone resorption through protein kinase B–mediated vesicle transport (2012) (37)
Cross-sectional comparison of coronary artery calcium scores between Caucasian men in the United States and Japanese men in Japan: the multi-ethnic study of atherosclerosis and the Shiga epidemiological study of subclinical atherosclerosis. (2014) (37)
Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation. (2016) (36)
Reduced adiponectin level is associated with severity of coronary artery disease. (2007) (36)
Dysadipocytokinemia in werner syndrome and its recovery by treatment with pioglitazone. (2004) (36)
A combination of serum low albumin and above-average cholesterol level was associated with excess mortality. (2004) (36)
Effectiveness of smoking-cessation intervention in all of the smokers at a worksite in Japan. (2000) (36)
Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2013) (36)
PI3K is a negative regulator of IgE production. (2008) (35)
Fast‐acting insulin aspart versus insulin aspart in the setting of insulin degludec‐treated type 1 diabetes: Efficacy and safety from a randomized double‐blind trial (2018) (35)
Insulin Resistance and Growth Retardation in Mice Lacking Insulin Receptor Substrate‐1 and Identification of Insulin Receptor Substrate‐2 (1996) (35)
Deficiency of Insulin Receptor Substrate‐1 Impairs Skeletal Growth Through Early Closure of Epiphyseal Cartilage (2003) (35)
Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases (2008) (35)
Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study. (2008) (35)
Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia (2014) (35)
Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence[S] (2010) (35)
Peroxisome Proliferator-activated Receptor γ Agonist Rosiglitazone Increases Expression of Very Low Density Lipoprotein Receptor Gene in Adipocytes*♦ (2009) (34)
Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609* (2011) (34)
Psychological and behavioural patterns of stigma among patients with type 2 diabetes: a cross-sectional study (2017) (34)
What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population? (2005) (34)
Relationship Between BMI and All‐cause Mortality in Japan: NIPPON DATA80 (2008) (34)
Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms (1992) (33)
Germ-line contribution of embryonic stem cells in chimeric mice: influence of karyotype and in vitro differentiation ability. (1997) (33)
Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions (2012) (33)
Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis. (2011) (33)
Plant sterols increased IL-6 and TNF-α secretion from macrophages, but to a lesser extent than cholesterol. (2011) (33)
Multifactorial intervention has a significant effect on diabetic kidney disease in patients with type 2 diabetes. (2020) (33)
Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies (2003) (33)
Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men (2016) (33)
Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin. (1993) (33)
Higher levels of adiponectin in American than in Japanese men despite obesity. (2006) (33)
Adiponectin/AdipoR Research and Its Implications for Lifestyle-Related Diseases (2019) (32)
Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction. (1990) (32)
Electrocardiogram Screening for Left High R-Wave Predicts Cardiovascular Death in a Japanese Community-Based Population: NIPPON DATA90 (2006) (32)
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding. (2005) (32)
Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b–mediated microtubule stabilization (2013) (32)
Validity and applicability of a simple questionnaire for the estimation of total and domain-specific physical activity (2011) (32)
gamma-Glutamyltransferase predicts cardiovascular death among Japanese women. (2007) (32)
Adiponectin Enhances Quiescence Exit of Murine Hematopoietic Stem Cells and Hematopoietic Recovery Through mTORC1 Potentiation (2017) (32)
Pdx1 Expression in Irs2-deficient Mouse β-Cells Is Regulated in a Strain-dependent Manner* (2003) (32)
Joint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up (2007) (32)
Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus (2014) (31)
Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. (1993) (31)
The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals (2011) (31)
Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity (2013) (31)
The role of PPARgamma in high-fat diet-induced obesity and insulin resistance. (2002) (31)
Lower cardiorenal risk with sodium‐glucose cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes without cardiovascular and renal diseases: A large multinational observational study (2020) (31)
Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance (the J-PREDICT study): rationale, study design, and clinical characteristics of 1269 patients (2011) (31)
The role of endothelial insulin signaling in the regulation of glucose metabolism (2013) (31)
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. (1994) (30)
Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals (2009) (30)
Phosphorylation state and biological function of a mutant human insulin receptor Val996. (1990) (30)
Colestilan monotherapy significantly improves glycaemic control and LDL cholesterol levels in patients with type 2 diabetes: a randomized double‐blind placebo‐controlled study (2010) (30)
Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency. (2011) (30)
Factors associated with presence and severity of toenail onychomycosis in patients with diabetes: a cross-sectional study. (2011) (29)
Expression Levels of Adiponectin Receptors are Decreased in Human Endometrial Adenocarcinoma Tissues (2012) (29)
Impact of Genetic Background and Ablation of Insulin Receptor Substrate (IRS)-3 on IRS-2 Knock-out Mice* (2003) (29)
Mutations of the Gs a-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis (29)
Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells (2012) (29)
The Epigenome and Its Role in Diabetes (2012) (29)
Elevated plantar pressure in diabetic patients and its relationship with their gait features. (2014) (29)
Testing the Feasibility and Usability of a Novel Smartphone-Based Self-Management Support System for Dialysis Patients: A Pilot Study (2017) (29)
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts. (1997) (28)
Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance. (1997) (28)
A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10. (1995) (28)
Diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu)(UUR) mutation: insulin secretion and sensitivity. (1997) (28)
Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population (2005) (28)
Adiponectin receptors are downregulated in human gastric cancer (2010) (28)
Alcohol consumption and coronary artery calcium in middle-aged Japanese men. (2006) (28)
Insulin edema in diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu(UUR)) mutation; case reports. (1995) (28)
A Mr = 190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the c-erbB-2 gene. (1987) (28)
Usage Patterns of GlucoNote, a Self-Management Smartphone App, Based on ResearchKit for Patients With Type 2 Diabetes and Prediabetes (2019) (28)
Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner (2017) (28)
Insulin resistance due to mutations of the insulin receptor gene: An overview (1992) (28)
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer (2020) (27)
The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample. (2007) (27)
Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice (2012) (27)
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes (2018) (27)
The role of PPARγ as a thrifty gene both in mice and humans (2000) (27)
Efficacy and safety of teneligliptin added to canagliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: A multicentre, randomized, double‐blind, placebo‐controlled, parallel‐group comparative study (2017) (27)
Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial (2022) (27)
Hemoglobin A1c Levels and the Risk of Cardiovascular Disease in People Without Known Diabetes (2015) (26)
Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases. (1992) (26)
Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages (2013) (26)
Role of insulin receptor substrates in the progression of hepatocellular carcinoma (2017) (26)
Rapid stimulation of fluid-phase endocytosis and exocytosis by insulin, insulin-like growth factor-I, and epidermal growth factor in KB cells. (1988) (26)
Factors Associated With Callus in Patients with Diabetes, Focused on Plantar Shear Stress During Gait (2016) (26)
Dosing of insulin glargine to achieve the treatment target in Japanese type 2 diabetes on a basal supported oral therapy regimen in real life: ALOHA study subanalysis. (2012) (26)
Stimulation of endometrium embryo transfer (SEET): injection of embryo culture supernatant into the uterine cavity before blastocyst transfer can improve implantation and pregnancy rates. (2007) (26)
Insulin receptor substrate 1 (IRS‐1) plays a unique role in normal epidermal physiology (2007) (25)
Efficacy and safety of sitagliptin add-on therapy in Japanese patients with type 2 diabetes on insulin monotherapy (2013) (25)
Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector (2019) (25)
Comparisons between anthropometric indices for predicting the metabolic syndrome in Japanese. (2008) (25)
Efficacy and safety of teneligliptin add-on to insulin monotherapy in Japanese patients with type 2 diabetes mellitus: a 16-week, randomized, double-blind, placebo-controlled trial with an open-label period (2017) (25)
Addition of sitagliptin to ongoing metformin monotherapy improves glycemic control in Japanese patients with type 2 diabetes over 52 weeks (2012) (25)
Sitagliptin added to treatment with ongoing pioglitazone for up to 52 weeks improves glycemic control in Japanese patients with type 2 diabetes (2011) (25)
Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients (2020) (25)
Efficacy and safety of insulin glulisine in Japanese patients with type 1 diabetes mellitus (2009) (24)
Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID study. (2010) (24)
Predicting Operational Tolerance in Pediatric Living-Donor Liver Transplantation by Absence of HLA Antibodies (2013) (24)
Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample: The Shigaraki Study (2006) (24)
How self-stigma affects patient activation in persons with type 2 diabetes: a cross-sectional study (2020) (24)
Fish consumption and early atherosclerosis in middle-aged men. (2007) (24)
[Insulin-sensitizing agents]. (1999) (24)
Differential expression of peroxisome proliferator-activated receptor in histologically different human gastric cancer tissues. (2006) (24)
Pancreatic β-Cell-specific Targeted Disruption of Glucokinase Gene (1995) (24)
Effect of combined cardiovascular risk factors on individual and population medical expenditures: a 10-year cohort study of national health insurance in a Japanese population. (2007) (24)
Mutations in the insulin receptor gene in genetic forms of insulin resistance. (1990) (24)
Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. (2017) (24)
Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the β-Catenin / T Cell Factor (TCF) Pathway (2008) (23)
The p85α Regulatory Subunit of Class IA Phosphoinositide 3-Kinase Regulates β-Selection in Thymocyte Development1 (2007) (23)
Stimulation of endometrium embryo transfer can improve implantation and pregnancy rates for patients undergoing assisted reproductive technology for the first time with a high-grade blastocyst. (2009) (23)
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms (2016) (23)
Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study. (2015) (23)
Sitagliptin added to voglibose monotherapy improves glycemic control in patients with type 2 diabetes (2013) (23)
A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites. (2013) (23)
Design of and rationale for the Japan Diabetes Optimal Integrated Treatment study for 3 major risk factors of cardiovascular diseases (J-DOIT3): a multicenter, open-label, randomized, parallel-group trial (2016) (23)
Long-Term Pancreas Allograft Survival in Simultaneous Pancreas-Kidney Transplantation by Era (2010) (23)
Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men. (2010) (23)
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (23)
Influence of cigarette smoking on coronary artery and aortic calcium among random samples from populations of middle-aged Japanese and Korean men (2012) (23)
Different effects of blood pressure on mortality from stroke subtypes depending on BMI levels: a 19-year cohort study in the Japanese general population—NIPPON DATA80 (2005) (23)
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice. (2001) (22)
Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial (2015) (22)
AUDIT study. Evidence of global undertreatment of dyslipidaemia in patients with type 2 diabetes mellitus (2006) (22)
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism. (2006) (22)
Analysis of the Pancreatic β Cell in the Mouse with Targeted Disruption of the Pancreatic β Cell-Specific Glucokinase Gene (1996) (22)
Impact of increased PPARgamma activity in adipocytes in vivo on adiposity, insulin sensitivity and the effects of rosiglitazone treatment. (2008) (22)
Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study. (2008) (22)
Analysis of the structural features of the C-terminus of GLUT1 that are required for transport catalytic activity. (1995) (22)
Glucokinase gene mutation and impaired glucose uptake by liver (1993) (22)
Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans. (1992) (21)
Biosimilar vs originator insulins: Systematic review and meta‐analysis (2018) (21)
Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men. (2015) (21)
Living-donor liver transplantation at the University of Tokyo, 1996-2011: the impact of HLA matching and a positive crossmatch on long-term survival and tolerance. (2011) (21)
Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men. (2009) (21)
Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice. (2012) (21)
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase. (2004) (21)
Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men. (2010) (21)
Critical role of class IA PI3K for c-Rel expression in B lymphocytes. (2009) (21)
Continuation of Smoking Cessation and Following Weight Change after Intervention in a Healthy Population with High Smoking Prevalence (2006) (21)
Primary Heterologous Carcinosarcoma of the Ureter with Necrotic Malignant Polyps (2003) (21)
Association between tear and blood glucose concentrations: Random intercept model adjusted with confounders in tear samples negative for occult blood (2020) (20)
Design of and rationale for the Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System (J-DREAMS) (2017) (20)
Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second‐generation antipsychotics: A cross‐sectional study using baseline data (2011) (20)
Protein kinase cascade activated by mechanical stress in cardiocytes: possible involvement of angiotensin II. (1995) (20)
Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet. (2012) (20)
Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis (2012) (20)
Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus. (1994) (20)
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate. (2005) (20)
Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in Japanese subjects with impaired glucose tolerance (2015) (20)
Two aberrant splicings caused by mutations in the insulin receptor gene in cultured lymphocytes from a patient with Rabson-Mendenhall's syndrome. (1998) (20)
Mutant of Insulin Receptor Substrate-1 Incapable of Activating Phosphatidylinositol 3-Kinase Did Not Mediate Insulin-stimulated Maturation of Xenopus laevis Oocytes* (1996) (20)
Antibody-mediated insulin resistance treated by cessation of insulin administration. (2000) (20)
DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients (2012) (19)
Difference in carotid intima-media thickness between Korean and Japanese men. (2008) (19)
Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. (2020) (19)
Variation in process quality measures of diabetes care by region and institution in Japan during 2015-2016: an observational study of nationwide claims data. (2019) (19)
Dipeptidyl peptidase-4 inhibitor anagliptin ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet. (2013) (19)
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. (2012) (19)
Unusual forms of insulin resistance. (1991) (19)
Hepatic IRS1 and ß-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients (2018) (19)
ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling. (2003) (19)
Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2 (2015) (18)
Association of Lipoprotein-associated Phospholipase A2 with Coronary Calcification among American and Japanese Men (2007) (18)
LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men. (2013) (18)
Retrospective nationwide study on the trends in first‐line antidiabetic medication for patients with type 2 diabetes in Japan (2021) (18)
Structural Basis and Genotype–Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance (2017) (18)
Cigarette smoking in middle age and a long-term risk of impaired activities of daily living: NIPPON DATA80. (2010) (18)
Population Attributable Fraction of Smoking and Metabolic Syndrome on Cardiovascular Disease Mortality in Japan: a 15-Year Follow Up of NIPPON DATA90 (2010) (18)
An analysis of long-term survival from the OPTN/UNOS Pancreas Transplant Registry. (2007) (18)
Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases. (2009) (17)
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. (2007) (17)
Characteristics of human erythrocyte insulin-like growth factor I receptors. (1986) (17)
Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene. (2010) (17)
A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. (2014) (17)
Successful desensitization by glargine administration in a patient with insulin allergy: a case report. (2009) (17)
The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development. (2007) (17)
The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking. (2013) (17)
Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. (2014) (17)
Willingness of patients with diabetes to use an ICT-based self-management tool: a cross-sectional study (2017) (16)
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits (2012) (16)
Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population (2012) (16)
Impact of Hypertension on Medical Economics: A 10-Year Follow-Up Study of National Health Insurance in Shiga, Japan (2005) (16)
The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90 (2007) (16)
Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus (2017) (16)
Insights into molecular pathogenesis of type 2 diabetes from knockout mouse models. (2002) (15)
Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance. (1991) (15)
Combined Analysis of Polymorphisms in Angiotensinogen and Adducin Genes and Their Effects on Hypertension in a Japanese Sample: The Shigaraki Study (2005) (15)
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3‐kinase signalling (2003) (15)
Incidence and predictors of hypoglycemia in Japanese patients with type 2 diabetes treated by insulin glargine and oral antidiabetic drugs in real-life: ALOHA post-marketing surveillance study sub-analysis (2014) (15)
Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells. (2003) (15)
Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self‐management: A cross‐sectional study (2017) (15)
NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation (2020) (15)
Detection of mutations in the human insulin gene by single strand conformation polymorphisms. (1992) (15)
Role of protein kinase system in the signal transduction of stretch-mediated protooncogene expression and hypertrophy of cardiac myocytes (1993) (15)
Validating the use of photos to measure dietary intake: the method used by DialBetics, a smartphone-based self-management system for diabetes patients (2016) (15)
Insulin-induced cell cycle progression is impaired in chinese hamster ovary cells overexpressing insulin receptor substrate-3. (2004) (15)
Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity (2021) (15)
A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes (2017) (15)
Association between type 1 diabetes mellitus and remitting seronegative symmetrical synovitis with pitting edema: a case report. (2011) (15)
The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. (2018) (14)
Persistence of oral antidiabetic treatment for type 2 diabetes characterized by drug class, patient characteristics and severity of renal impairment: A Japanese database analysis (2018) (14)
Alcohol intake and 19-year mortality in diabetic men: NIPPON DATA80. (2009) (14)
Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones (2006) (14)
Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values. (2002) (14)
Long‐term safety and efficacy of canagliflozin as add‐on therapy to teneligliptin in Japanese patients with type 2 diabetes (2017) (14)
Risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japan. (1994) (14)
The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype. (2009) (14)
Efficacy and safety of once‐daily insulin degludec dosed flexibly at convenient times vs fixed dosing at the same time each day in a Japanese cohort with type 2 diabetes: A randomized, 26‐week, treat‐to‐target trial (2016) (14)
Phosphorylation of fodrin (nonerythroid spectrin) by the purified insulin receptor kinase. (1985) (14)
Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus (2017) (14)
Prognostic value of q wave for cardiovascular death in a 19-year prospective study of the Japanese general population. (2009) (14)
The evaluation of materials to provide health-related information as a population strategy in the worksite: The high-risk and population strategy for occupational health promotion (HIPOP-OHP) study (2004) (14)
Relation of Gamma-glutamyltransferase and alcohol drinking with incident diabetes: the HIPOP-OHP study. (2010) (14)
Effectiveness of two-step (consecutive) embryo transfer in patients who have two embryos on day 2: comparison with cleavage-stage embryo transfer. (2005) (14)
Bundle branch block and other cardiovascular disease risk factors: US-Japan comparison. (2010) (14)
Detecting occult coronary artery disease followed by early coronary artery bypass surgery in patients with diabetic retinopathy: report from a diabetic retinocoronary clinic. (2010) (14)
Long-Term, Real-World Safety and Efficacy of Teneligliptin: A Post-Marketing Surveillance of More Than 10,000 Patients with Type 2 Diabetes in Japan (2019) (14)
Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis (2013) (14)
Genes associated with diabetes: potential for novel therapeutic targets? (2016) (13)
Safety and Efficacy of Teneligliptin in Patients with Type 2 Diabetes Mellitus and Impaired Renal Function: Interim Report from Post-marketing Surveillance (2018) (13)
The association between health literacy levels and patient-reported outcomes in Japanese type 2 diabetic patients (2019) (13)
[Regulation of differentiation and hypertrophy of adipocytes and adipokine network by PPARgamma]. (2010) (13)
Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine. (2008) (13)
Decreased insulin secretion and accumulation of triglyceride in beta cells overexpressing a dominant-negative form of AMP-activated protein kinase. (2010) (13)
Coronary calcification is more predictive of carotid intimal medial thickness in black compared to white middle aged men. (2008) (13)
Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial. (2022) (13)
[The mechanisms by which PPARgamma and adiponectin regulate glucose and lipid metabolism]. (2003) (13)
Establishment of a method of anonymization of DNA samples in genetic research (2003) (13)
- Cell Glucokinase Deficiency and Hyperglycemia Are Associated With Reduced Islet Amyloid Deposition in a Mouse Model of Type 2 Diabetes (2000) (13)
Effect of linagliptin, a dipeptidyl peptidase-4 inhibitor, compared with the sulfonylurea glimepiride on cardiovascular outcomes in Asians with type 2 diabetes: subgroup analysis of the randomized CAROLINA® trial (2020) (12)
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement. (2011) (12)
Identification of type 2 diabetes loci in 433,540 East Asian individuals (2020) (12)
Mutation in the mitochondrial tRNAleu at position 3243 and spontaneous abortions in Japanese women attending a clinic for diabetic pregnancies (1995) (12)
Outcome of Liver Transplantation for Recipients With Hepatitis B and Hepatitis C Virus Coinfection: Analysis of the UNOS Data (2011) (12)
Safety and efficacy of long-term treatment with teneligliptin: Interim analysis of a post-marketing surveillance of more than 10,000 Japanese patients with type 2 diabetes mellitus (2018) (12)
Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells. (2011) (12)
Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway. (2008) (12)
Long-term safety, tolerability, and efficacy of the dipeptidyl peptidase-4 inhibitor sitagliptin in Japanese patients with type 2 diabetes (2011) (12)
corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2004) (12)
[The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance]. (2001) (12)
Shear Stress-Normal Stress (Pressure) Ratio Decides Forming Callus in Patients with Diabetic Neuropathy (2016) (12)
Smoking scenes in popular Japanese serial television dramas: descriptive analysis during the same 3-month period in two consecutive years. (2006) (12)
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1 (2001) (12)
Marital Status and Cardiovascular Risk Factors among Middle‐aged Japanese Male Workers: The High‐risk and Population Strategy for Occupational Health Promotion (HIPOP‐OHP) Study (2008) (12)
Factors associated with deep foot fissures in diabetic patients: a cross-sectional observational study. (2012) (12)
Activation of MAP kinase and enhanced phosphorylation of the 350-kDa protein by mitogenic stimuli in quiescent Balb/c 3T3 cells. (1991) (12)
Formation of distinct signalling complexes involving phosphatidylinositol 3‐kinase activity with stimulation of epidermal growth factor or insulin‐like growth factor‐I in human skin fibroblasts (1999) (11)
Cardiovascular outcomes and safety with linagliptin, a dipeptidyl peptidase‐4 inhibitor, compared with the sulphonylurea glimepiride in older people with type 2 diabetes: A subgroup analysis of the randomized CAROLINA trial (2020) (11)
Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release (2014) (11)
Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462 (1995) (11)
International Comparison of Abdominal Fat Distribution Among Four Populations: The ERA-JUMP Study. (2018) (11)
Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population (2012) (11)
Erratum: The HIPOP-OHP Research Group: A prospective study of passive smoking and risk of diabetes in a cohort of workers: The High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study (Diabetes Care (2008) 31 (732-734)) (2008) (11)
Inhibition of Peroxisome Proliferator-Activated Receptor γ Promotes Tumorigenesis Through Activation of the β-Catenin/T Cell Factor (TCF) Pathway in the Mouse Intestine (2008) (11)
The Death Effector Domain-containing DEDD Supports S6K1 Activity via Preventing Cdk1-dependent Inhibitory Phosphorylation* (2009) (11)
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men (2021) (11)
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. (2009) (11)
Protective role of imatinib in atherosclerosis. (2004) (11)
Relationships between family histories of stroke and of hypertension and stroke mortality: Nippon Data80, 1980–1999 (2008) (11)
Cardiovascular and kidney outcomes of linagliptin treatment in older people with type 2 diabetes and established cardiovascular disease and/or kidney disease: A prespecified subgroup analysis of the randomized, placebo‐controlled CARMELINA® trial (2020) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Anagliptin increases insulin-induced skeletal muscle glucose uptake via an NO-dependent mechanism in mice (2016) (11)
Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity. (2018) (10)
The determinants of plasma plasminogen activator inhibitor-1 levels differ for American and Japanese men aged 40-49. (2006) (10)
Descriptive epidemiology of diabetes prevalence and HbA1c distributions based on a self-reported questionnaire and a health checkup in the JPHC diabetes study. (2014) (10)
Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2. (2006) (10)
SnapShot: Physiology of Insulin Signaling (2012) (10)
[SGLT2 inhibitor]. (2020) (10)
Measuring Platelet Aggregation in Dialysis Patients With a Whole Blood Aggregometer by the Screen Filtration Pressure Method (2011) (10)
High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding* (2005) (10)
Insulin receptor disorders in Japan. (1994) (10)
Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice. (2002) (10)
Serum ghrelin levels are higher in Caucasian men than Japanese men aged 40–49 years (2007) (10)
Lower heart failure and chronic kidney disease risks associated with sodium‐glucose cotransporter‐2 inhibitor use in Japanese type 2 diabetes patients without established cardiovascular and renal diseases (2021) (10)
Effectiveness and safety of basal supported oral therapy with insulin glargine, in Japanese insulin-naive, type 2 diabetes patients, with or without microvascular complications: subanalysis of the observational, non-interventional, 24-week follow-up Add-on Lantus® to Oral Hypoglycemic Agents (ALOHA) (2015) (10)
Reconsideration of insulin signals induced by improved laboratory animal diets, Japanese and American diets, in IRS-2 deficient mice. (2009) (10)
Human adiponectin receptor AdipoR1 assumes closed and open structures (2020) (10)
Oral aversion to dietary sugar, ethanol and glycerol correlates with alterations in specific hepatic metabolites in a mouse model of human citrin deficiency. (2017) (10)
[PPAR gamma agonist and antagonist]. (2001) (10)
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The role of PPARgamma as a thrifty gene both in mice and humans. (2000) (10)
Purified tyrosine kinases, the EGF receptor kinase and the src kinase, can catalyze the phosphorylation of the band 3 protein from human erythrocytes. (1986) (10)
KLF6 in nonalcoholic fatty liver disease: role of fibrogenesis and carcinogenesis. (2008) (10)
Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese. (2016) (10)
Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency. (2015) (9)
Successfully achieving target weight loss influences subsequent maintenance of lower weight and dropout from treatment (2015) (9)
Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus (2020) (9)
AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice (2021) (9)
CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway (2017) (9)
Methodological issues for a large-scale intervention trial of lifestyle modification: Interim assessment of the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study (2004) (9)
New glycemic targets for patients with diabetes from the Japan Diabetes Society (2016) (9)
A 3-basepair in-frame deletion (delta Leu999) in exon 17 of the insulin receptor gene in a family with insulin resistance. (1994) (9)
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Generation of Transgenic Mice on an NOD/SCID Background Using the Conventional Microinjection Technique1 (2011) (9)
Effects of insulin glulisine as mono‐ or add‐on therapy in patients with type 2 diabetes mellitus (2009) (9)
Mutations of the human insulin receptor gene (1990) (9)
Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization (2013) (9)
Efficacy and Safety of Teneligliptin 40 mg in Type 2 Diabetes: A Pooled Analysis of Two Phase III Clinical Studies (2018) (9)
Peroxisome proliferator-activated receptors and insulin secretion. (2005) (9)
The role of PPARg in high-fat diet-induced obesity and insulin resistance (2002) (9)
Effect of short‐term treatment with sitagliptin or glibenclamide on daily glucose fluctuation in drug‐naïve Japanese patients with type 2 diabetes mellitus (2018) (8)
Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week open-label extension (2017) (8)
Randomized controlled trial of single‐agent glimepiride and pioglitazone in Japanese patients with type 2 diabetes: A comparative study (2011) (8)
Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population. (2008) (8)
Hexamminecobalt(III) Chloride Inhibits Glucose-induced Insulin Secretion at the Exocytotic Process* (2001) (8)
The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract. (2005) (8)
DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections. (2016) (8)
A closer inspection of diabetes-related stigma: why more research is needed (2019) (8)
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model (2019) (8)
IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. (2011) (8)
Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies. (2011) (8)
Overexpression of MCP-1 in adipose tissues causes macrophage recruitment and insulin resistance (2006) (8)
Is weak association between cigarette smoking and cardiovascular disease mortality observed in Japan explained by low total cholesterol? NIPPON DATA80. (2007) (8)
Insulin Resistance Syndrome in Mice Deficient in Insulin Receptor Substrate‐1 (1997) (8)
[PPAR and diabetes]. (2005) (8)
Adrenal myelolipoma: Report of a case with CT and angiographic evaluation (1983) (8)
Overexpression of the glycogen targeting (G(M)) subunit of protein phosphatase-1. (2000) (8)
Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1 (2011) (7)
Maturity-onset Diabetes of the Young Resulting from a Novel Mutation in the HNF-4α Gene (2002) (7)
Development of a food frequency and quantity method for assessing dietary habits of Japanese individuals--comparison with results from 24hr recall dietary survey. (2008) (7)
LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia (2020) (7)
Islet cell antibody in mitochondrial diabetes. (1997) (7)
Relationship between elevated plantar pressure of toes and forefoot and gait features in diabetic patients (2013) (7)
γ-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA90 (2010) (7)
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice. (2009) (7)
Low-risk profile for cardiovascular disease and mortality in Japanese. (2008) (7)
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Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase ( p 125 FAK ) in Cultured Rat Cardiac Myocytes (1999) (7)
Evaluation of organ-specific glucose metabolism by 18F-FDG in insulin receptor substrate-1 (IRS-1) knockout mice as a model of insulin resistance (2011) (7)
Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. (1996) (7)
Effectiveness of annual interventions for smoking cessation in an occupational setting in Japan (2004) (7)
Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans (2011) (7)
Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering (2017) (7)
Ethnic difference in liver fat content: a cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States. (2013) (7)
[Pathogenesis of metabolic syndrome]. (2006) (7)
A case of insulin allergy successfully managed using multihexamer‐forming insulin degludec combined with liraglutide (2016) (7)
Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases (2019) (7)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) (2006) (7)
Switch to Anaerobic Glucose Metabolism with NADH Accumulation in the β-Cell Model of Mitochondrial Diabetes (2002) (7)
Impact of COVID-19 pandemic on healthcare service use for non-COVID-19 patients in Japan: retrospective cohort study (2022) (7)
Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan (2011) (7)
Stimulation of the phosphorylation of cytoskeletal 350-kDa and 300-kDa proteins by insulin-like growth factor-I, platelet-derived growth factor and phorbol ester in rat 3Y1 cells. (1988) (7)
Predictors for achieving target glycemic control in Japanese patients with type 2 diabetes after initiation of basal supported oral therapy using insulin glargine: sub-analysis of the ALOHA2 study, drug use surveillance in Japan (2016) (6)
Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency (2019) (6)
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Are comprehensive environmental changes as effective as health education for smoking cessation? (2006) (6)
Safety of Empagliflozin in Patients With Type 2 Diabetes and Chronic Kidney Disease: Pooled Analysis of Placebo-Controlled Clinical Trials (2022) (6)
A Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene. (2001) (6)
Improved Treatment Satisfaction and Self-reported Health Status after Introduction of Basal-Supported Oral Therapy Using Insulin Glargine in Patients with Type 2 Diabetes: Sub-Analysis of ALOHA2 Study (2015) (6)
Study of the Correlation between Tear Glucose Concentrations and Blood Glucose Concentrations (2018) (6)
Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society (2020) (6)
What unfavorable factors are associated with low serum total cholesterol in a Japanese population? (2002) (6)
Real-world Observational Study on Patient Outcomes in Diabetes (RESPOND): study design and baseline characteristics of patients with type 2 diabetes newly initiating oral antidiabetic drug monotherapy in Japan (2020) (6)
Diabetes and COVID-19: IDF perspective in the Western Pacific region (2020) (6)
Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis. (2003) (6)
Causes of graft failure in simultaneous pancreas-kidney transplantation by various time periods. (2013) (6)
The Japanese Medical Science Federation COVID-19 Expert Opinion English Version (2021) (6)
Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men (2010) (6)
Differential effects of apolipoprotein E isoforms on lipolysis of very low-density lipoprotein triglycerides. (2006) (6)
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Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity (2019) (6)
Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator‐activated receptor γ (+/−) mice independent of adipocyte size (2003) (6)
Incidence of foot ulcers in patients with diabetes at a university hospital in Tokyo over a 5-year period (2015) (6)
Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease (2021) (6)
Weekly Versus Daily Dipeptidyl Peptidase 4 Inhibitor Therapy for Type 2 Diabetes: Systematic Review and Meta-analysis (2018) (6)
Retraction Note: Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade (2014) (6)
[Electron-beam computed tomography for identification of high-risk persons in primary prevention of coronary heart disease in the United States and its implication for Japan]. (2003) (6)
Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes. (2021) (6)
Thermographic findings in a case of type 2 diabetes with foot ulcer due to callus deterioration (2017) (6)
Diabetes Care Providers’ Manual for Disaster Diabetes Care (2019) (5)
The other sweet face of XBP-1 (2011) (5)
Long-term safety and efficacy of alogliptin, a DPP-4 inhibitor, in patients with type 2 diabetes: a 3-year prospective, controlled, observational study (J-BRAND Registry) (2021) (5)
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Does self-reported history of hypertension predict cardiovascular death? Comparison with blood pressure measurement in a 19-year prospective study (2007) (5)
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men (2022) (5)
Effects of anti-diabetes medications on cardiovascular and kidney outcomes in Asian patients with type 2 diabetes: a rapid evidence assessment and narrative synthesis (2021) (5)
Factors associated with long-term care certification in older adults: a cross-sectional study based on a nationally representative survey in Japan (2021) (5)
[PPAR family (PPAR alpha, PPAR delta, PPAR gamma)]. (2002) (5)
Association between Washing Residue on the Feet and Tinea Pedis in Diabetic Patients (2015) (5)
Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2019) (5)
Loss of insulin receptor substrate-1 signaling induces the cardiovascular and proteo(fibrino)lytic system derangements typical of insulin resistance (2005) (5)
[Weight-control intervention in overweight subjects at high risk of cardiovascular disease: a trial of a public health practical training program in a medical school]. (2004) (5)
Single‐nucleotide polymorphisms in the 17β‐hydroxysteroid dehydrogenase genes might predict the risk of side‐effects of estramustine phosphate sodium in prostate cancer patients (2005) (5)
Safety and efficacy of addition of sitagliptin to rapid-acting insulin secretagogues for glycemic control, including post-prandial hyperglycemia, among Japanese with type 2 diabetes mellitus (2016) (5)
Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways (2016) (5)
PI 3 K and Btk differentially regulate B cell antigen receptor-mediated signal transduction (2003) (5)
Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice (2008) (4)
ENPP2 contributes to adipose tissue expansion in diet-induced obesity (2014) (4)
An analysis of the OPTN/UNOS Liver Transplant Registry. (2009) (4)
Effects of Prophylactic Antibiotics on Length of Stay and Total Costs for Pediatric Acute Pancreatitis: A Nationwide Database Study in Japan. (2020) (4)
Outcomes of lactulose plus branched‐chain amino acid infusion and lactulose alone for hepatic encephalopathy: A retrospective cohort study using a national inpatient database (2020) (4)
Assessment of cardiometabolic risk and prevalence of meeting treatment guidelines among patients with type 2 diabetes stratified according to their use of insulin and/or other diabetic medications: results from INSPIRE ME IAA (2013) (4)
Metabolic Syndrome and Adipokines (2005) (4)
Using mHealth to Provide Mobile App Users With Visualization of Health Checkup Data and Educational Videos on Lifestyle-Related Diseases: Methodological Framework for Content Development (2020) (4)
Importance of standardization of hemoglobin A1c in the analysis of factors that predict hemoglobin A1c levels in non-diabetic residents of three distinct areas of Japan. (2001) (4)
Risk factor effects and total mortality in older Japanese men in Japan and Hawaii. (2008) (4)
Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene. (2013) (4)
28‐week, randomized, multicenter, open‐label, parallel‐group phase III trial to investigate the efficacy and safety of biphasic insulin aspart 70 thrice‐daily injections vs twice‐daily injections of biphasic insulin aspart 30 in patients with type 2 diabetes (2010) (4)
Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men (2020) (4)
Comparison of Gait Features Between Feet With Callus or Corns and Normal Feet Using Motion Sensors in People With Diabetes and People Without Diabetes (2016) (4)
Protocol for a large-scale prospective observational study with alogliptin in patients with type 2 diabetes: J-BRAND Registry (2014) (4)
Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable. (2007) (4)
Adenovirus-mediated gene transfer and lipoprotein-mediated protein delivery of plasma PAF-AH ameliorates proteinuria in rat model of glomerulosclerosis. (2006) (4)
Effectiveness of a smoking-cessation intervention and comprehensive environmental changes: A new but classical experience from Japan (2011) (4)
Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A post hoc subgroup analysis of the PIONEER 1, 3, 4 and 8 trials (2021) (4)
Cost of healthcare utilization associated with incident cardiovascular and renal disease in individuals with type 2 diabetes: A multinational, observational study across 12 countries (2022) (4)
Time Spent Walking and Risk of Diabetes in Japanese Adults: The Japan Public Health Center-Based Prospective Diabetes Study. (2016) (4)
The Association between Tinea Pedis and Feet-Washing Behavior in Patients with Diabetes: A Cross-sectional Study (2017) (4)
Novel and Simple Ultrasonographic Methods for Estimating the Abdominal Visceral Fat Area (2017) (4)
Lipoprotein-associated phospholipase A2 regulates macrophage apoptosis via the Akt and caspase-7 pathways. (2014) (4)
Education and management of diabetes at The University of Tokyo Hospital (2011) (4)
Survival Pathways Are at the Divergence of CD 40-Mediated B / Rel κ Phosphatidylinositol 3-Kinase and NF (2000) (4)
Relationship of Eating Patterns and Metabolic Parameters, and Teneligliptin Treatment: Interim Results from Post-marketing Surveillance in Japanese Type 2 Diabetes Patients (2018) (4)
Cross-sectional association of bone mineral density with coronary artery calcification in an international multi-ethnic population-based cohort of men aged 40–49: ERA JUMP study (2020) (4)
Differences Between Patient-Reported Versus Clinician-Observed Nonulcerative Signs and Symptoms of the Foot in Patients With Diabetes Mellitus (2019) (4)
[Intraperitoneal spontaneous rupture of the bladder subsequent to irradiation of the uterus: a case report]. (1988) (4)
Long-Term Safety and Efficacy of Teneligliptin in Elderly Patients with Type 2 Diabetes: Subgroup Analysis of a 3-Year Post-Marketing Surveillance in Japan (2020) (4)
Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: design and baseline characteristics of the AYAME study (2022) (4)
Silent myocardial ischaemia in patients with diabetic retinopathy (2014) (4)
[Persistent müllerian duct syndrome with seminoma: report of a case]. (1992) (3)
Willingness of Patients Prescribed Medications for Lifestyle-Related Diseases to Use Personal Health Records: Questionnaire Study (2020) (3)
Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study (2020) (3)
History of Having a Macrosomic Infant and the Risk of Diabetes: The Japan Public Health Center-Based Prospective Diabetes Study (2013) (3)
Manifestation of Heart Failure and Chronic Kidney Disease are Associated with Increased Mortality Risk in Early Stages of Type 2 Diabetes Mellitus: Analysis of a Japanese Real-World Hospital Claims Database (2022) (3)
[The role of PPARgamma in the onset of type 2 diabetes]. (2003) (3)
A randomized, placebo‐controlled study to evaluate the efficacy and safety of adding omarigliptin to insulin therapy in Japanese patients with type 2 diabetes and inadequate glycaemic control (2021) (3)
Coffee consumption and risk of type 2 diabetes mellitus (2003) (3)
[Obesity: Progress in diagnosis and treatment; Topics, III. Obesity and its complications; 1. Obesity and diabetes]. (2011) (3)
[Genetic susceptibility of type 2 diabetes]. (2003) (3)
Efficacy and Safety of Faster Aspart Compared with Insulin Aspart Both with Insulin Degludec in Adults with T1D (2018) (3)
Development of an Automatic Puncturing and Sampling System for a Self-Monitoring Blood Glucose Device. (2017) (3)
Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies (2021) (3)
Incidence of gastrointestinal toxicity during estramustine phosphate therapy for prostate cancer is associated with the single-nucleotide polymorphisms in the cytochrome P450 1A1 (CYP1A1) gene (2005) (3)
Adipocyte-Derived Adiponectin Positively Regulates Exit from Quiescence of Hematopoietic Stem Cells By Potentiating mTORC1 Activation after Myelotoxic Injury (2015) (3)
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity (2018) (3)
206-LB: Cardiorenal Disease Is the Most Common First CV Manifestation in Type 2 Diabetes and Associated with Increased Mortality: A Large Multinational Observational Study (2019) (3)
Association Between Plasma Triglycerides and HDL-Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes: A Global Case-Control Study in 13 Countries (2013) (3)
Author response for "Lower Cardiorenal Risk with Sodium-Glucose Cotransporter-2 Inhibitors versus Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Patients without Cardiovascular and Renal Diseases: A large multinational observational study" (2020) (3)
Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan (2022) (3)
Frequency of diabetic retinopathy and related factors in patients with diabetes having coronary artery disease. (2016) (3)
Substitution of Arginine for Histidine at Position 209 in the a-Subunit of the Human Insulin Receptor (2001) (3)
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects (2001) (3)
Efficacy and safety assessment of basal supported oral therapy (BOT) with insulin glargine in a real-life clinical setting, stratified by concomitant orally administered antidiabetic agent (OAD) regimens including dipeptidyl peptidase-4 inhibitor (DPP-4i): subanalysis of the ALOHA2 study, drug-use s (2016) (3)
An Efficient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background. (2008) (3)
Ornithine decarboxylase induction during liver regeneration in IRS-1-deficient mice. (1995) (3)
Prevalence of vitreous hemorrhage following coronary revascularization in patients with diabetic retinopathy. (2011) (3)
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Diabetes care providers’ manual for disaster diabetes care (2019) (3)
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Peroxisome Proliferator-activated Receptor -mediated Regulation of Neural Stem Cell Proliferation (2006) (3)
Unpleasant Alcohol Effect in Diabetes Associated With 3243 bp Mitochondrial tRNALeu(UUR) Mutation (1995) (3)
[Achieving better control of blood sugar--understanding of oral hypoglycemic agents according to their characteristics in pharmacological action mechanism (discussion)]. (2004) (3)
Fast and Accurate Ultrasonography for Visceral Fat Measurement (2010) (3)
35th Annual Meeting of the European Association for the Study of Diabetes (2016) (3)
Glimepiride-Induced Bronchial Asthma (2008) (3)
[The mechanisms by which PPAR gamma regulates fat storage and insulin sensitivity]. (2001) (3)
Nodular Glomerulosclerosis (Kimmelstiel-Wilson) After Total Pancreatectomy (1987) (2)
Understanding the experiences of long-term maintenance of self-worth in persons with type 2 diabetes in Japan: a qualitative study (2020) (2)
Association between nutritional guidance or ophthalmological examination and discontinuation of physician visits in patients with newly diagnosed diabetes: A retrospective cohort study using a nationwide database (2021) (2)
Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance. (2020) (2)
Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study (2018) (2)
Factors Associated with Callus Formation in the Plantar Region through Gait Measurement in Patients with Diabetic Neuropathy: An Observational Case-Control Study (2020) (2)
Automatic distance measurement of abdominal aorta for ultrasonography-based visceral fat estimation (2013) (2)
High-resolution CCD linear image sensors for the advanced visible and near-infrared radiometer (AVNIR) (1995) (2)
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Erratum: Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population: NIPPON DATA90 (Hypertension Research (2006) vol. 29 (353-360)) (2006) (2)
[Estimated relative and absolute risk for cardiovascular disease according to alcohol consumption increase in Japanese general population]. (2001) (2)
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Plasma glucose monitoring and the subsequent HbA1c control in patients with type 2 diabetes on a basal supported oral therapy regimen in real life: subanalysis of the ALOHA study: a 24-week, prospective, open-label, multicenter, observational study (2015) (2)
First Report of Detection of Lysophosphatidic Acids (LPAs) and Analysis of LPA Quantity in a Human Embryo-Conditioned Medium (2015) (2)
Simultaneous pancreas-kidney transplantation in the United States: an analysis of the UNOS registry. (2010) (2)
Correction to: Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity (2021) (2)
[Treatment of diabetes mellitus with oral hypoglycemic agents]. (2011) (2)
Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population (2018) (2)
The PREDICTIVETM Study: a multinational, prospective observational study to evaluate the safety and efficacy of insulin detemir treatment in patients with type 1 and 2 diabetes—data from the Japan cohort (2012) (2)
What expectations do young Japanese epidemiologists have for the future of epidemiology? A questionnaire survey of members of the young epidemiologists society for discussing the future of epidemiology. (2004) (2)
Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients. (2005) (2)
Lung abscess without sepsis in a patient with diabetes with refractory episodes of spontaneous hypoglycemia: a case report and review of the literature (2014) (2)
[Genomics of type 2 diabetes]. (2002) (2)
Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes and inadequate glycaemic control on sitagliptin (2021) (2)
Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice (2015) (2)
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Blood Glucose Control Strategy for Type 2 Diabetes Patients With COVID-19 (2020) (2)
Alcohol Drinking and Brain Morphometry in Apparently Healthy Community-Dwelling Japanese Men. (2020) (2)
Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus (2021) (2)
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Preceding psychological factors and calorie intake in patients with type 2 diabetes: investigation by ecological momentary assessment (2019) (2)
Efficacy and Safety of Fast-Acting Insulin Aspart in People with Type 1 Diabetes Using Carbohydrate Counting: A Post Hoc Analysis of Two Randomised Controlled Trials (2019) (2)
Screening of Foot Inflammation in Diabetic Patients by Non-Invasive Imaging Modalities (2011) (2)
Issue Information (2018) (2)
Diabetes mellitus defined by hemoglobin A1c value: Risk characterization for incidence among Japanese subjects in the JPHC Diabetes Study (2011) (2)
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[Diabetes and osteoporosis]. (2004) (2)
[PPARgamma antagonist as a potential drug for the treatment of obesity and diabetes]. (2010) (2)
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Effects of beraprost sodium, an oral prostacyclin analog, on insulin resistance in patients with type 2 diabetes (2015) (2)
Metabolic syndrome : carcinogenesis and prevention : Extended abstracts for the 39th International Symposium of the Princess Takamatsu Cancer Research Fund : November 11-13, 2008 Tokyo, Japan (2009) (2)
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A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice (2021) (2)
Correction to: Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity (2021) (1)
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice (2022) (1)
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Molecular Pathogenesis of Type 2 Diabetes Mellitus and Obesity in Knockout Mice Models (2000) (1)
1876-P: Gut Microbial Fermentation of Polysaccharides Impacts Insulin Resistance in Humans (2020) (1)
Potassium concentration in initial fluid therapy and in-hospital mortality of patients with diabetic ketoacidosis. (2021) (1)
Major complications after percutaneous biopsy of native or transplanted liver in pediatric patients: a nationwide inpatient database study in Japan (2022) (1)
Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125) in Cultured Rat Cardiac Myocytes (1999) (1)
Akt1 in Osteoblasts and Osteoclasts Controls Bone (2007) (1)
[Adiponectin receptor-targeted therapy for lifestyle-related diseases]. (2016) (1)
Abstract LB-174: Genome-wide association meta-analysis identifies novelGP2gene risk variants for pancreatic cancer in the Japanese population (2019) (1)
Pseudo‐hyperglucagonemia was observed in pancreatectomized patients when measured by glucagon sandwich enzyme‐linked immunosorbent assay (2020) (1)
Long-Term Pancreas Allograft Survival in Simultaneous Pancreas-Kidney Transplantation by Era. (2015) (1)
Efficacy of the Self-management Support System DialBetesPlus for Diabetic Kidney Disease: Protocol for a Randomized Controlled Trial (2021) (1)
The sodium‐glucose co‐transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE‐deficient mice with streptozotocin‐induced diabetes (2022) (1)
Lactic acidosis due to attempted suicide with metformin overdose: A case report. (2016) (1)
Clinical care and other categories posters: Incretin therapies (2019) (1)
Pathogen-induced systemic plant signal triggers DNA rearrangements (2003) (1)
[Epigenetics and Life-style diseases]. (2016) (1)
[New diagnostic criteria of diabetes mellitus in Japan, 2010]. (2010) (1)
[New drug targets for the metabolic syndrome and obesity]. (2012) (1)
A Machine Learning-Based Predictive Model to Identify Patients Who Failed to Attend a Follow-up Visit for Diabetes Care After Recommendations From a National Screening Program. (2022) (1)
[New diabetes mellitus models: gene targeting]. (1998) (1)
[The Update of Obesity Syndrome: Molecular Mechanism, Pathophysiology and Therapies. Topics: II. Recent Topics on Care and Treatment of the Obesity Syndrome; 3. Pharmacotherapy of obesity]. (2015) (1)
[Smoking scenes in Japanese television dramas]. (2003) (1)
Societal Marketing in the Treatment of Type 2 Diabetes Mellitus: A Longitudinal Questionnaire Survey for Michelin-Starred Restaurants in Japan (2019) (1)
Voices: Insulin and beyond. (2021) (1)
Betel Chewing and Risk of Metabolic Disease, Cardiovascular Disease, and All-Cause Mortality: A Meta-Analysis. (2014) (1)
Body Composition is Main Determinant for the Difference in Type 2 Diabetes Pathophysiology between Japanese and Caucasians Short running title: Type 2 Diabetes in Japanese and Caucasians (2013) (1)
887-P: Development of the Noninvasive Diabetes Monitoring Method (2020) (1)
[108th Scientific Meeting of the Japanese Society of Internal Medicine: invited lecture: 4. Molecular mechanism and treatment strategy of type 2 diabetes]. (2011) (1)
Sweat gland atrophy of the heel in diabetic patients with angiopathy. (2013) (1)
Corrigendum to "Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population." [Atherosclerosis 246 (March 2016) 141-147]. (2018) (1)
[Endothelial function and insulin resistance]. (2008) (1)
53 Involvement in the Pathogenesis of Fatty Liver Disease * (2004) (1)
Comprehensive IDF-WPR diabetes and disasters manual, 2nd edition available. (2022) (1)
Safety and efficacy of switching thrice-daily treatment with NovoRapid®70Mix (BIAsp70) to BIAsp70 before breakfast and lunch and NovoRapid®30Mix (BIAsp30) before dinner in patients with type 2 diabetes: subgroup analysis of a phase III trial (2011) (1)
[Recent advances in PPARs research--basic and clinical aspects]. (2005) (1)
Vascular Endothelial Growth Factor Induces Activation and Subcellular Translocation of Focal Adhesion Kinase (p125 FAK ) in Cultured Rat Cardiac Myocytes (1999) (1)
ASSOCIATION OF DONOR-SPECIFIC HLA ANTIBODY WITH ACUTE REJECTION IN LIVING-DONOR LIVER TRANSPLANTATION: A POSSIBLE EVIDENCE OF HUMORAL SENSITIZATION: 3230 (2010) (1)
[Gene targeting approaches for diabetes research]. (2005) (1)
[Insulin resistance in central nerve system]. (2006) (1)
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease (2019) (1)
[Glucokinase knockout mice]. (1998) (1)
O-46: Insulin signalling and insulin actions in the muscle, adipose tissue and liver of insulin resistant IRS-1 deficient mice (2009) (1)
[Diagnostic standard for fasting and postprandial hyperglycemia]. (2009) (1)
Impairment of M2a-Subtype Macrophage Activation by Il-4-Irs2 Pathway in Obesity (2018) (1)
Comment on: Lin et al. Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection. Diabetes Care 2013;36:701–707 (2013) (1)
Reply: Injection of embryo culture supernatant prior to blastocyst transfer—cofactor? (2008) (1)
[Role of NADH shuttle system in glucose-stimulated insulin secretion]. (2002) (1)
Effects of Liraglutide on (cid:1) -Cell-Specific Glucokinase-Deficient Neonatal Mice (2012) (1)
ADDITION-Europe: the first decade and beyond. (2019) (1)
Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study (2021) (1)
Feasibility, acceptability, and effects of a self-stigma reduction pilot program for Japanese individuals with type 2 diabetes (2023) (1)
[Developing Exercise-mimicking Drugs toward Realization of Preemptive Medicine for Lifestyle-related Diseases.] (2018) (1)
[IRS-1 knockout mouse]. (1998) (1)
RNA Interference Technology: Generation of highly specific vector-based shRNAi libraries directed against the entire human genome (2005) (1)
[Mutations in the insulin receptor gene in patients with genetic forms of insulin resistance]. (1991) (1)
Association Between Plasma Triglycerides and HDL-Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes : A Global Case-Control Study in 13 Countries Running title : (2013) (1)
Corrigendum: Combating diabetes and obesity in Japan (2006) (1)
[The role of phosphorylation cascade in insulin action]. (1994) (1)
Synthetic gene circuits: Insulin self-regulation (2017) (1)
NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes (2022) (1)
Insulin, bombyxin and their hybrids: Synthesis and activity (1993) (1)
Sodium-Glucose Cotransporter 2 Inhibitors for Type 1 Diabetes Mellitus—Systematic Review and Meta-analysis (2018) (1)
Adiponectin and its receptors in insulin resistance, diabetes, and metabolic syndrome, and obesity (2008) (1)
Issue Information (2018) (0)
4. Molecular Mechanism and Treatment Strategy of Type 2 Diabetes. (2011) (0)
OE-318 Maintenance of Cardiac and Adipose PAI-1 Expression Despite the Lack of IRS-1 : a Knockout Mouse Study(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English)) (2004) (0)
Subacute adrenal hemorrhage by blunt abdominal contusion during snowboarding (Case report) (2008) (0)
Insulin-like Growth Factor I (IGF-I) Therapy in a Patient with Severe Insulin Resistance Syndrome (1994) (0)
A Case of Diabetic Amyotrophy Mitochondria ) tRNA ( leu ; UUR ) Therapy with Coenzyme Q 10 Associated with 3243 Mutation and Successful (2006) (0)
[Neurofibrosarcoma of the perineum associated with von Recklinghausen's disease: a case report and review of the literature]. (1983) (0)
Structural basis of ethnic-specific variants of PAX 4 associated with type 2 1 diabetes 2 3 (2020) (0)
COVID‐19 in a neurofibromatosis 1 patient accompanied by brain tumor hemorrhage (2022) (0)
Session 1 S 1-1 AMP-activated protein kinase in CRH neurons in the PVH controls food selection behavior (2014) (0)
[Classification of mutations in the insulin receptor gene]. (1994) (0)
Comparison of bleeding complications after pediatric kidney biopsy between intravenous sedation and general anesthesia: a nationwide cohort study (2023) (0)
SUBACUTE ADRENAL HEMORRHAGE BY BLUNT ABDOMINAL CONTUSION DURING SNOWBOARDING SUBACUTE ADRENAL HEMORRHAGE BY BLUNT ABDOMINAL CONTUSION (2008) (0)
Patient referral flow between physician and ophthalmologist visits for diabetic retinopathy screening among Japanese patients with diabetes: A retrospective cross-sectional cohort study using the National Database. (2023) (0)
[A case of vesicosigmoidal fistula]. (1988) (0)
Abstract P321: Influence of Cigarette Smoking on Coronary and Aortic Calcification Among Community-based Middle-aged Japanese and Korean Men (2012) (0)
Obesity and diseases. 3. Molecular mechanisms of obesity and insulin resistance. (1998) (0)
Development of a high-performance liquid chromatographic glycated albumin assay using finger-prick blood samples. (2023) (0)
Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector (2019) (0)
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target (2017) (0)
Human adiponectin receptor AdipoR1 assumes closed and open structures (2020) (0)
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications (2023) (0)
A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice (2021) (0)
Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men (2023) (0)
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model (2019) (0)
Role of insulin receptor substrates in the progression of hepatocellular carcinoma (2017) (0)
Communications antenna for CS-2 (1982) (0)
Mo-P1:45 Prediction of cardiovascular death by self-reported past history of hypertension in a 19-year cohort study in Japan (2006) (0)
Mo-P1:63 Association between family history of stroke and mortality from ischemic stroke among Japanese (2006) (0)
1086-P: A Retrospective Nationwide Surveillance on the First-Line Antidiabetic Medication for the Patients with Type 2 Diabetes in Japan (2021) (0)
Abstract 4942: Identification of Insulin Receptor Substrate Family Proteins Mediating PAI-1 Production in Cardiac and Adipose Tissues From IRS-1 Null Mice (2006) (0)
Signaling Pathway Proliferation and Migration via the ERK Healing by Promoting Keratinocyte Adiponectin Regulates Cutaneous Wound (2012) (0)
[Perspective for development of insulin sensitizers]. (2002) (0)
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis. (2021) (0)
[Hypoglycemic agents to improve insulin resistance]. (2000) (0)
Running title : Cell interactions in adipogenesis (2007) (0)
1A2-O08 Simultaneous measurement system of plantar pressure and shear forces to identify factors associated with callus in diabetic patients(Nursing and Mechatronics) (2012) (0)
Peroxisome Proliferator-Activated Receptor &ggr; Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo (2002) (0)
Abstract 2837: Adiponectin knockout enhances intestinal carcinogenesis in Min and wild-type mice (2011) (0)
Effect of Branched-Chain Amino Acid Infusion on In-Hospital Mortality of Patients With Hepatic Encephalopathy and End-Stage Kidney Disease: A Retrospective Cohort Study Using a National Inpatient Database. (2021) (0)
Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy‐associated progeroid syndrome due to an LMNA variant: A case report (2022) (0)
[Disease concept of type 2 diabetes]. (2012) (0)
Abstract 13031: Universal Screening for Familial Hypercholesterolemia in Young Adults: The Young FH Study (2020) (0)
Role of mitochondrial NADH shuttle system in acute amylase secretion by acetylcholine from mouse pancreatic acinar cells. (2002) (0)
Abstract 394: Posttranslational Modification Of Klf5 Mediates Metabolic Dysfunction And Vascular Disease In Metabolic Syndrome (2007) (0)
Role of Structural Biology for Target Molecules of Diseases in Drug Development (2012) (0)
Abstract 3643: Consciousness of Reduced Salt Diet and Actual Achievement of Salt Reduction Estimated from 24hr Urinary Na Excretions in General Populations in Japan, PRC, UK and US: The INTERMAP Study (2007) (0)
Treatment patterns and satisfaction in patients with type 2 diabetes newly initiating oral monotherapy with antidiabetic drugs in Japan: results from the prospective Real-world Observational Study on Patient Outcomes in Diabetes (RESPOND) (2022) (0)
Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes (2023) (0)
Erratum: Psychological Factors, Coffee and Risk of Diabetes Mellitus among Middle-Aged Japanese: a Population-Based Prospective Study in the JPHC Study Cohort [Endocrine Journal Vol. 56 (3): 459-468, 2009] (2011) (0)
Issue Information (2017) (0)
Alcohol consumption and subclinical and clinical coronary heart disease: A Mendelian randomization analysis. (2022) (0)
Role of the liver in glucose homeostasis in PI 3-kinase p85 (cid:1) -deﬁcient mice (2009) (0)
Evi1 Is a Stem Cell-Specific Regulator of Self-Renewal Capacity In the Definitive Hematopoietic System (2010) (0)
Abstract 11292: Modulation of Lipoprotein and Glucose Metabolism with the Over-expression of Niemann-pick C1 Like 1 Protein (NPC1L1) In Mice Liver (2010) (0)
Issue Information (2019) (0)
Real-World Evidence of Treatment with Teneligliptin/Canagliflozin Combination Tablets for Type 2 Diabetes Mellitus: A Post-Marketing Surveillance in Japan (2022) (0)
[Impaired glucose tolerance (IGT): current understanding and future research directions]. (2005) (0)
Elucidating exercise-induced skeletal muscle signaling pathways and applying relevant findings to preemptive therapy for lifestyle-related diseases. (2021) (0)
Analysis ofthestructural features oftheC-terminus ofGLUT1that are required fortransport catalytic activity (1995) (0)
Serum n 2 6 fatty acids and lipoprotein subclasses in middle-aged men : the population-based cross-sectional ERA-JUMP Study 1 – 3 (2010) (0)
[Protein kinase C activation and diabetic complications]. (2005) (0)
Abstract P084: Influence Of Amount And Rapidity Of Weight Loss On The Risk Of Subsequently Regaining Weight And Drop-out From Treatment Among Patients With Severe Obesity Dieting In Hospital Without Bariatric Surgery (2014) (0)
Issue information (2019) (0)
AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice (2021) (0)
Comprehensive evaluation of type 2 diabetes susceptibility loci in the Japanese population by using 1000 Genomes Project data (2012) (0)
[Defects in insulin's signalling process and diabetes mellitus]. (1997) (0)
Characteristics of subjects with type 2 diabetes enrolled in randomized controlled trials and non‐randomized controlled trials in Japan: A systematic review (2022) (0)
Polymorphism of the Angiotensinogen Gene and Hypertension in a Japanese General Population (the Shigaraki Study) (2003) (0)
RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNOEA, OTHER CARDIOVASCULAR RISK FACTORS AND CARDIOVASCULAR DISEASE (2018) (0)
Abstract P363: Cross-Sectional Comparison of Coronary Artery Calcium Prevalence between Japan and the US: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013) (0)
O-45: Annexin II — a novel element in insulin signal transduction: role of annexin-II phosphorylation in insulin receptor internalization (2009) (0)
Abstract 5466: In Vivo Molecular Imaging Revealed Chronic Inflammation and Increased Adhesion Molecules in Obese Adipose Tissue in Mice (2008) (0)
Influence of Recipient Age On Long-Term Simultaneous Pancreas Kidney Transplants: An Analysis of UNOS Data.: Abstract# B1276 (2014) (0)
Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin (2015) (0)
Abstract 1614: Neutral Cholesterol Ester Hydrolase is Essential for Cholesterol Removal in Human Macrophages and Atherosclerosis (2009) (0)
YI-838 KLF5 PLAYS A PIVOTAL ROLE IN METABOLIC REGULATION AND ATHEROSCLEROSIS (2007) (0)
Corrigendum to ‘Gamma-Glutamyltransferase and mortality risk from heart disease and stroke in Japanese men and women: NIPPON DATA 90’ (2011) (0)
[Practice guidelines review: Diabetes mellitus]. (2002) (0)
Agents ameliorant la resistance a l'insuline (2002) (0)
Abstract 2770: Difference in Serum Levels of Docosahexaenoic Acid (DHA) May Explain the Difference in Carotid Intima-Media Thickness Between US White and Japanese Men Aged 40 49 (2006) (0)
Evaluation of glycated albumin levels in tears and saliva as a marker in patients with diabetes mellitus. (2023) (0)
Cholesteryl Ester Transfer Protein, Coronary Calcium and Intima-media Thickness of the Carotid Artery in Middle-Aged Japanese Men (2010) (0)
Hyponatremia and Sulfonylureas: A Reply (1984) (0)
BRACHIAL-ANKLE PULSE WAVE VELOCITY IS ASSOCIATED WITH CORONARY CALCIFICATION AMONG 1,131 HEALTHY MIDDLE-AGED MEN (2015) (0)
Correction: Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis (2014) (0)
Abstract 2319: Genetic Variations Of Mrf-2/Arid5b Confer Risk Of Coronary Artery Disease And Diabetes Mellitus In The Japanese Population (2007) (0)
Abstract P069: The Relationship of Serum Marine-Derived N-3 Fatty Acids and Carotid Intima-Media Thickness among General Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013) (0)
Naoto Cardiac Hypertrophy In Vitro and In Vivo Plays a Critical Role in Inhibition of γ Peroxisome Proliferator-Activated Receptor (2002) (0)
Crystal structure of the human adiponectin receptor 1 D208A mutant (2020) (0)
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism (2019) (0)
PJ-296 Heterozygous PPAR γ Deficient Mice Showed Increased Neointima Formation with Vascular Smooth Muscle Cell Proliferation in Response to Cuff Injury(Atherosclerosis, Basic 3 (IHD) : PJ50)(Poster Session (Japanese)) (2004) (0)
A transgenic mutant mouse line accompanied by the complete deletion of interleukin-33 showed insulin and leptin resistances (2018) (0)
[Molecular pathogenesis of type 2 diabetes mellitus]. (1999) (0)
patients The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic (2011) (0)
Vascular Intima Formation in Insulin Receptor Substrate-2 Deficient Mice (2002) (0)
[Knockout mouse models for type 2 diabetes. Mice with impaired insulin secretion]. (2002) (0)
[Adipocytes and bone metabolism]. (2011) (0)
Issue Information (2015) (0)
Smartphone-Based Self Management System for Type-2 Diabetes Patients (2012) (0)
Anti-Obese Hormone Adiponectin Regulates Emergency Hematopoiesis and Antibacterial Response Through Downregulation Of Socs3 In Hematopoietic Progenitor Cells (2013) (0)
OriginatArticle SP ' e " : ciii-[ i = ii ialIssuec , The Evaluation ofMaterials to Provide Health-Related Information as a Population Strategy in the Worksite : The High-Risk and Population Strategy for Occupational Health Promotion ( HIPOP-OHP ) Study (2017) (0)
Signiﬁcant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1 (2012) (0)
Issue Information (2016) (0)
A Novel Xanthene Derivative, DS20060511, Attenuates Glucose Intolerance by Inducing Skeletal Muscle-specific GLUT4 Translocation in Diabetic Mice (2020) (0)
[Knockout mouse models for type 2 diabetes. Mice with insulin resistance]. (2002) (0)
Differential roles of insulin and IGF-1 in murine keratinocyte differentiation (2000) (0)
Mo-P1:48 Long-term outcome after stroke among the participants of the national survey on circulatory disordeers in Japan (Nippon Data80, 1980–1994) (2006) (0)
Physiological roles of adiponectin and adiponectin receptors (2006) (0)
[113th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Insight into the Mechanism of Diseases on New Perspective Arising in Internal Medicine: From Epigenetics to Organ Associations: Novel Insight into Physiological and Pathophysiological Roles of Adipocytes -Elucidation (2016) (0)
Additions and Corrections (2006) (0)
[Pathophysiological roles of adipocytokines in the development of insulin resistance]. (2012) (0)
Adiponectin receptors AdipoR (2011) (0)
Abstract 14137: A Newly Identified Case of Apolipoprotein C-II Deficiency Associated with Reduced Transcriptional Activity (2010) (0)
Genetic Factor and Molecular Pathogenesis of Diabetes (2002) (0)
Takashi Kadowaki and Naoto Kubota Protective Role of Imatinib in Atherosclerosis (2004) (0)
2P-0348 EBT (electron-beam CT) and risk factor assessment among Japanese and US men in the post World War II birth cohort: ERA-JUMP (2003) (0)
Prediction of pregnancy and delivery rates by blastocyst morphological score and age, based on 1488 single frozen-thawed blastocyst transfer cycles (2010) (0)
Diminished Left Ventricular Function and Coronary Perivascular Fibrosis Associated with Insulin Resistance do not Require Insulin Receptor Substarte-1 Mediated Signaling (2002) (0)
[Aging and homeostasis. Development of novel AdipoR-targeted drugs with exercise-mimicking and anti-aging properties.] (2017) (0)
Issue Information (2018) (0)
Role of the insulin receptor kinase activity in insulin action. (1988) (0)
Ensuring Success for J-NIH (2013) (0)
Influence of Insulin Receptor Substrate–2–Knockout on the Activity of Experimental Choroidal Neovascular in Mice Model (2006) (0)
PL01 MOLECULAR BIOLOGY OF TYPE II DIABETES (2006) (0)
Association of Anti-HLA Antibody with Operational Tolerance in Pediatric Living-Donor Liver Transplantation: A Possible Evidence of Humoral Sensitization: 1531 (2012) (0)
A method of selectively testing of adiponectinmultimeren (2004) (0)
Efficacy of the Self-management Support System DialBetesPlus for Diabetic Kidney Disease: Protocol for a Randomized Controlled Trial (Preprint) (2021) (0)
Crystal structure of the human adiponectin receptor 1 (2015) (0)
Lack of Brain Insulin Receptor Substrate-1 (IRS1) Causes Growth Retardation via Growth Hormone Releasing Hormone (2018) (0)
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population (2019) (0)
Class IA PI3K is involved in the pre-B cell antigen receptor-mediated signaling (86.6) (2007) (0)
2) Treatment Strategies for Preventing Atherosclerosis in Patients with Diabetes Mellitus. (2010) (0)
4. Recent Topics of the Mechanism and Treatment of Diabetes Mellitus (2009) (0)
[Current status of analysis of type 2 diabetes genes]. (2002) (0)
2P-0323 What cause of mortality can we predict by high density lipoprotein cholesterol (HDLC) in the Japanese general population? NIPPONDATA90 (2003) (0)
Tu-P7:53 KLF5 is involved in both metabolic regulation and atherosclerotic lesion formation (2006) (0)
Issue Information (2017) (0)
Mo-P1:58 The relationship between alcohol intake and traditional or non-traditional risk factors for cardiovascular disease in the middle-aged Japanese men (2006) (0)
Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner (2017) (0)
Brief Genetics Report A Polymorphism in the AMPK (cid:1) 2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population (2006) (0)
Chair’s Summary (2011) (0)
Abstract 5475: A Novel Lipase, Neutral Cholesteryl Ester Hydrolase, is a Major Regulator of Neutral Cholesteryl Ester Hydrolysis in Murine Macrophages. (2008) (0)
Prediction of the efficacy and safety of pioglitazone in patients with type 2 diabetes mellitus (2005) (0)
Adiponectin is a potent inhibitor of gastric cancer. (2006) (0)
Co-localization of NFIA and PPARγ controls the brown fat gene program (2016) (0)
P-241 Associations of CRP and Fibrinogen with Subclinical Atherosclerosis in Whites in US, Japanese-American in Hawaii and Japanese in Japan (2009) (0)
Abstract 17671: The Critical Role of Sterol Regulatory Element-binding Protein-1c in Hypertriglyceridemia Caused by Apolipoprotein A5 Deficiency (2016) (0)
, R receptor substrate 1-deficient mice . muscles and livers of insulin-resistant , insulin Insulin signalling and insulin actions in the (1996) (0)
Using mHealth to Provide Mobile App Users With Visualization of Health Checkup Data and Educational Videos on Lifestyle-Related Diseases: Methodological Framework for Content Development (Preprint) (2020) (0)
Preface (1992) (0)
Ka-band communications antenna for Superbird (1990) (0)
Human Brown Adipose Tissue Density Assessed by Near-Infrared Time-Resolved Spectroscopy Inversely Correlates with the Body Mass Index in Patients with Type 2 Diabetes (2018) (0)
Cognitive impairment and task-specific incident disability: Japanese cohort study (2006) (0)
Issue Information (2017) (0)
Mo-P1:31 Influence of cigarette smoking on coronary and aortic calcification among community-based Japanese young men (2006) (0)
The Prevalence of Gastrointestinal Symptoms Depends on Disease Duration and Gastrointestinal Tract Region in Patients with Type 2 Diabetes (2018) (0)
Impact of body mass index on in-hospital mortality in older patients hospitalized for bacterial pneumonia with non-dialysis-dependent chronic kidney disease (2022) (0)
NFIA Controls Brown-Fat Gene Program by Differential Chromatin Remodeling of Cell Type-Specific Enhancers (2015) (0)
Safety and efficacy of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in monotherapy and in combination therapy with antihyperglycemic agents in patients with type 2 diabetes mellitus - An interim analysis of post-marketing surveillance, RUBY- (2018) (0)
3P-0712 Heterozygous PPAR γ deficient mice showed impaired endothelium-dependent vascular relaxation and increased neointima formation in response to cuff injury (2003) (0)
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases (2020) (0)
Tu-P9:344 The metabolic syndrome and preclinical atherosclerosis in middle-aged Japanese men (2006) (0)
KLF5 is important for both metabolic regulation and atherosclerotic lesion formation (2006) (0)
Selective Ablation of IRS-1 Decreases Cardiac Contractility without Attenuating PAI-1 Expression or Perivascular Fibrosis (2003) (0)
Adipose Tissue Remodeling, Chronic Inflammation and T-cell-macrophage Interactions in Obesity Visualized by in vivo Molecular Imaging Method (2009) (0)
Association of serum n 2 6 and n 2 3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men 1 – 3 (2009) (0)
Tofogliflozin Suppresses the Progression of Atherosclerosis and Reduces Inflammation in Macrophages of STZ-Diabetic ApoE KO Mice due to Improvement of Glucose Tolerance (2018) (0)
PE-537 Identification of the Novel MEF2-Kruppel-like Factor 5 (KLF5) Network That Associates with Cardiovascular Disease(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society) (2007) (0)
Evaluation of Pancreatic Graft Function Using 11C-Methionine Positron Emission Tomography in Pancreas Transplantation. K. Otsuki,1 (2017) (0)
[A trend of insulin sensitizer which is under development]. (2001) (0)
Abstract P305: Incidence of Coronary Artery Calcification and Its Association With Eicosapentaenoic Acids From The ERA JUMP Study (2012) (0)
[Obesity and diseases. 3. Obesity and molecular structure of insulin resistance]. (1998) (0)
Mo-P1:137 Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population; Nippon data90 (2006) (0)
DOES CHRONIC INTERMITTENT HYPOXIA ALWAYS INCREASE BLOOD GLUCOSE LEVELS IN MICE? (2018) (0)
[Trends in therapy for diabetes mellitus]. (2002) (0)
[Perspective for personalized medicine for diabetes]. (2002) (0)
Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Prediabetes (2020) (0)
[Diabetic treatment strategies to control the onset and development of diabetic macrovascular disease]. (2010) (0)
[Diabetes and the metabolic syndrome]. (2006) (0)
Authors' Response to a Letter to the Editor Re: Differences Between Patient-Reported Versus Clinician-Observed Nonulcerative Signs and Symptoms of the Foot in Patients With Diabetes Mellitus. J Wound Ostomy Continence Nurs. 2019;46(2): Differences Between Patient-Reported Versus Clinician-Observed N (2019) (0)
Regulation of Chronic Myelogenous Leukemia Stem Cells by Leukemia Oncogene Evi1 (2011) (0)
5. Patients with Diabetes Difficult to Manage and Their Countermeasures (2018) (0)
Selective ablation of insulin receptor substrate-1 decreases cardiac contractility in vivo without attenuating PAI-1 expression or perivascular fibrosis (2003) (0)
[Importance of animal models by gene targeting in diabetes research]. (2002) (0)
[Functional food component--osmotin]. (2012) (0)
[Mitochondria gene mutation and diabetes]. (1996) (0)
Tu-W22:1 Role of adipokines in obesity-linked insulin resistance, metabolic syndrome and atherosclerosis (2006) (0)
NFIA Colocalizes with PPARgamma and Activates the Cell-Type–Specific Enhancers to Control the Brown Fat Gene Program (2018) (0)
ABBREVIATIONS MODY : maturation onset diabetes mellitus of the young MODY 2 : maturation onset diabetes mellitus of the young (2004) (0)
Effect modification of diabetes as a comorbidity on temperature variability and hospitalization for cardiovascular disease (2022) (0)
PPAR participates in both vasculogenesis and angiogenesis. (2004) (0)
Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes (2021) (0)
Long-term pancreas allograft survival in simultaneous pancreas-kidney transplantation by era. (2010) (0)
PE-411 KLF5 Controls Metabolic Stress Response in Metabolic Syndrome and Cardiovascular Disease(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society) (2007) (0)
Issue Information (2016) (0)
Issue Information (2018) (0)
[Recent advances in PPARgamma research]. (2010) (0)
characterized by an impaired response to GP VI stimulation null platelets α Functional phenotype of phosphoinositide 3-kinase p85 (2003) (0)
The mechanism by which adipocytes regulate insulin sensitivity (2004) (0)
JCB_201410052 1..14 (2015) (0)
[Assessment of insulin resistance by minimal model analysis]. (1997) (0)
Genotype–Phenotype Correlations and Structural Basis of INSR and IGF1R Mutations Causing Severe Insulin/IGF-1 Resistance (2018) (0)
[Action plan 2010 of Japan Diabetes Society (DREAMS)]. (2012) (0)
Crystal structure of the human adiponectin receptor 2 (2015) (0)
0863 ANALYSIS OF FOCAL ADHESION RELATED TYROSINE KINASE IN CARDIAC MYOCYTE STIMULATED BY VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) (1997) (0)
HYPERTENTION IN THE ELDERLY: ANALYSES ON NIPPON DATA80, 1980-94 (2004) (0)
926-P: Cardiovascular (CV) and Hypoglycemia Outcomes across Age Groups in People with Type 2 Diabetes (T2D) in the CAROLINA Trial (2020) (0)
A method for sample pretreatment and immunological assay method using thereof (2004) (0)
Organizing Committee and International Advisory Board (2012) (0)
OE-316 Kruppel-like family of transcription factor 5 is required for adipocyte differentiation(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English)) (2004) (0)
' s response to reviews Title : Population Attributable Fraction of Smoking and Metabolic Syndrome on Cardiovascular Disease Mortality in Japan : a 15-Year Follow Up of NIPPON DATA 90 (2010) (0)
Issue Information (2016) (0)
The Insulin Receptor Protein Kinase (1986) (0)
[Signaling molecules as the therapeutic targets for the metabolic syndrome]. (2006) (0)
Molecular Pathogenesis of Type 2 Diabetes in Knockout Mice Models (2000) (0)
For peer review only Impact of Male Pattern Baldness on Coronary Heart Disease: A meta-analysis (2012) (0)
C-terminal globulardomäne of adiponectin for treatment of atherosclerosis (2003) (0)
Molecular analysis of Cardiac Hypertrophy by Mechanical Stress:Involvement of Stretch-Induced Protein Kinase Cascade (1993) (0)
[Genetic factors and life styles related to diabetes mellitus--with special reference to multiple factor inheritance]. (2000) (0)
Abstract 5276: Sumoylation Of Klf5 Is A Molecular Switch Regulating Ppar-{delta}-containing Transcriptional Programs Of Lipid Metabolism (2008) (0)
CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway (2017) (0)
[Questionnaire survey of the POCT device antsense ROSE for blood glucose analysis on healthcare professionals--evaluation focused on preventive measures against cross-infections]. (2011) (0)
Issue Information (2016) (0)
Pathogenesis of NIDDM with a particular emphasis on molecular defects (1996) (0)
1741-P: Immune Regulation of Postprandial Glycemia and Whole-Body Insulin Sensitivity through Myeloid Production of IL-10 (2020) (0)
Lack of Insulin Receptor Substrate-2 Is a Link between Insulin Resistance and an Increased Intima of the Vessel in Mice (2003) (0)
Our sympathies to the people affected by the Great East Japan Earthquake, and the activities of the Japan Diabetes Society (2011) (0)
55-OR: Oral Semaglutide vs. Liraglutide and Placebo in T2D: PIONEER 4 (2019) (0)
[The roles of adipokines in the regulation of insulin sensitivity]. (2006) (0)
[MODY (maturity-on-set diabetes of the young)]. (1998) (0)
Issue Information (2016) (0)
Abstract 3901: Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia (2014) (0)
PDB7 Treatment of Type 2 Diabetes in JAPAN: An Evidence GAP Analysis Based on Systematic and Target Literature Review of Clinical Studies (2020) (0)
[Glucokinase gene and its dual promoter regions]. (1997) (0)
[113th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Elucidation of Pathogenesis and Development of Therapeutic Strategy of Type 2 Diabetes -Progress in the Thirty Years]. (2016) (0)
Issue Information (2016) (0)
Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants (2021) (0)
Signal Insulin Transduction-Like Growth Mechanism Factor-1 of Insulin and (2006) (0)
Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of 1 (2014) (0)
We-P11:12 Relationship of coronary heart disease mortality to casual blood glucose level and self-reported past history of diabetes mellitus (2006) (0)
Abstract P377: Prevalence of Carotid Plaque and Cardiovascular Risk Factors Among 40-49 Year Old White, Japanese American, Japanese in Japan and Korean Men from the ERA JUMP Study (2013) (0)
Faculty Opinions recommendation of Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. (2002) (0)
Anti-IRS-1 monoclonal antibody, 6G5, cross-reacts to IRS-2. (1996) (0)
[Molecular genetics of NIDDM]. (1997) (0)
[The 43rd Scientific Meeting: Perspectives of Internal Medicine; Genetic predisposition and related life-style underlying metabolic disorders 1. Preface]. (2016) (0)
Association Between Plasma Triglycerides and HDL-Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes: A Global Case-Control Study in 13 Countries Running title: Sacks et al.; Plasma lipids in diabetic microvascular disease (2013) (0)
[Control of lipid metabolism by insulin]. (2001) (0)
AdipoRon: An anti-diabetes and anti-aging drug (2018) (0)
BASIC—ALIMENTARY TRACT Loss of Adiponectin Promotes Intestinal Carcinogenesis in Min and Wild-type Mice (2011) (0)
Preface (2010) (0)
Tu-W22:3 Adiponectin modulates transcription factor activation by angiotensin II in smooth muscle cells (2006) (0)
ESICON 2018 Abstracts (2018) (0)
Long-term safety and effectiveness of linagliptin by baseline body mass index in Japanese patients with type 2 diabetes: a 3-year post-marketing surveillance study (2022) (0)
Issue Information (2019) (0)
Abstract 3850: The Ratio of Polyunsaturated to Saturated Fatty Acids in the Serum is a Strong Determinant of the Presence of Coronary Calcification Among US White and Japanese Men Aged 40 49 (2006) (0)
In vivo molecular imaging revealed obese adipose tissue remodeling and malfunction in metabolic syndrome (2008) (0)
Three-dimensional structure and receptor-recognition sites of bombyxin-II, an insulin-like brain-secretory peptide of the silkmoth (1999) (0)
Diabetes mellitus : Advances of research and medical care. VI. Recent topics. 1. Mitochondrial gene abnormalities and diabetes mellitus. (1996) (0)
1697-P: NFIA Differentially Regulates Adipogenesis and Myogenesis through Distinct Molecular Pathways to Ensure Adipocyte Differentiation (2020) (0)
Macrophages React to Postprandial Signals and Regulate the Response to Feeding through Akt-mTOR–Dependent Production of IL-10 (2018) (0)
Dose-Response Relationship Between Severe Hypercholesterolemia and Body Mass Index in Healthy Young Adults. (2017) (0)
[Hyponatremia induced by chlorpropamide]. (1983) (0)
The adiponectin receptor: Physiology and pharmacology (2018) (0)
KRÜPPEL-LIKE FACTOR 5 IS A KEY TRANSCRIPTION FACTOR OF ADIPOCYTE DIFFERENTIATION (2004) (0)
Issue Information (2017) (0)
28 SNPs OF ADIPONECTIN RECEPTOR GENES IN PEDIATRIC DIABETES AND OBESTY (2003) (0)
[Incretin related drugs]. (2010) (0)
2P-0328 Effect of egg intake on serum cholesterol, coronary and all cause mortality: NIPPON DATA80, 1980–1994 (2003) (0)
Mo-P1:14 Influence of smoking habit on residual lifetime risk of cardiovascular diseases in Japanese representative population (2006) (0)
[Glucose metabolism in adipose tissue]. (2002) (0)
Glucagon-like peptide (GLP)-1 analogues as an add-on to insulin for adults with type 1 diabetes mellitus (2018) (0)
Prevention of Worsening Diabetes through Behavioral Changes by an IoT-based Self-Monitoring System in Japan (PRISM-J): Study design and rationale for a multicenter, open-label, randomized parallel-group trial (2021) (0)
Selection in Thymocyte Development β Phosphoinositide 3-Kinase Regulates Regulatory Subunit of Class IA α The p 85 Suzuki and (2007) (0)
Controversies about the importance of increased waist circumference (0)
Age‐Dependent Association Between Modifiable Risk Factors and Incident Cardiovascular Disease (2023) (0)
Approach to the Pathogenesis of Non-Insulin-Dependent Diabetes Mellitus by Gene Targeting. (1997) (0)
Obese adipose tissue remodeling, malfunctioning, and chronic inflammation visualized by in vivo molecular imaging (2009) (0)
A randomized, placebo‐controlled trial to assess the efficacy and safety of sitagliptin in Japanese patients with type 2 diabetes and inadequate glycaemic control on ipragliflozin (2021) (0)
[Intensive glucose control and cardiovascular outcomes in diabetes and impaired glucose tolerance]. (2011) (0)
Abstract 19406: Amelioration of Streptozotocin-Induced Diabetic Hypertriglyceridemia in the Absence of Hormone-Sensitive Lipase (2016) (0)
Abstract 18320: A Novel Tandem Duplication Containing a Noncoding Exon of the APOC2 Gene Causes Chylomicronemia With Markedly Reduced Levels of Plasma Apolipoprotein C-II (2016) (0)
[Molecular structure related to the expression of insulin resistance and its evaluation]. (2004) (0)
Transgenic Approach to Insulin Signaling (2002) (0)
Osmotin is a Homolog of Human Adiponectin and Controls Apoptosis in Yeast Through a Homolog of Human Adiponectin Receptor (2004) (0)
2-B2-205 Developmental and functional impairment of B lymphocytes in mice lacking the p85a regulatory subunit of phosphatidylinositol-3 kinase (2008) (0)
[HAIR-AN syndrome]. (1994) (0)
[Anti-metabolic syndrome effects of candesartan]. (2009) (0)
Willingness of Patients Prescribed Medications for Lifestyle-Related Diseases to Use Personal Health Records: Questionnaire Study (Preprint) (2019) (0)
[Alcohol drinking habit and mortality]. (1997) (0)
Cross-sectional associations between the types/amounts of beverages consumed and the glycemia status: The Japan Public Health Center-based Prospective Diabetes study (2022) (0)
Daytime napping, daytime sleepiness and the risk of metabolic diseases: dose-response meta-analysis (2016) (0)
Effect of once-weekly subcutaneous semaglutide 2.4 mg on weight- and health-related quality of life in an East Asian population: Patient-reported outcomes from the STEP 6 trial. (2023) (0)
[Positioning of PROactive and its clinical application in Japan--a new direction in diabetes care discussed by diabetology and circulatory disease specialists: discussion]. (2006) (0)
Issue Information (2017) (0)
[Diabetes caused by glucokinase mutation]. (1998) (0)
[Lipid disorder and atherosclerosis caused by smoking]. (2001) (0)
Adiponectin and its receptors: A major role in type 2 diabetes and obesity-linked diseases (2016) (0)
[Current trend in the care of diabetic patients: discussion]. (2000) (0)
Issue Information (2017) (0)
Efficacy and safety of fast-acting insulin aspart compared with insulin aspart in combination with insulin degludec in Japanese adults with type 1 diabetes: a subgroup analysis of the randomized onset 8 trial. (2020) (0)
607-P: Glycemic Metrics in Japanese Flash Glucose Monitoring Users by Diabetes Type and Therapy (2021) (0)
Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging (2007) (0)
Failure of compensatory beta-cell hyperplasia in response to insulin resistance plays a crucial role in the development of type 2 diabetes (2000) (0)
[The use of new agents enhancing incretin effects for patients with diabetes in Japan]. (2011) (0)

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