Takashi Shimada
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Computer Science
Takashi Shimada's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Takashi Shimada's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Klotho converts canonical FGF receptor into a specific receptor for FGF23 (2006) (1711)
- FGF‐23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis (2003) (1631)
- Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. (2004) (1392)
- FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. (2004) (426)
- Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. (2002) (411)
- IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (1999) (391)
- hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA (1996) (375)
- Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. (2010) (352)
- Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. (2005) (326)
- Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. (2010) (316)
- The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. (1997) (311)
- Influence of hepatitis B virus genotypes on the intra‐ and extracellular expression of viral DNA and antigens (2006) (272)
- Novel transcription map for the B19 (human) pathogenic parvovirus (1987) (248)
- Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection (2005) (247)
- Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells (2003) (234)
- Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions. (1991) (227)
- Therapeutic Effects of Anti‐FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia (2009) (226)
- Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. (1989) (215)
- Cyanobacteriochrome CcaS is the green light receptor that induces the expression of phycobilisome linker protein (2008) (209)
- Anti‐FGF23 Neutralizing Antibodies Show the Physiological Role and Structural Features of FGF23 (2008) (188)
- The functional human dihydrofolate reductase gene. (1984) (186)
- Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. (2010) (181)
- Loss of Scribble causes cell competition in mammalian cells (2012) (143)
- Targeted ablation of Fgf 23 demonstrates an essential physiological role of FGF 23 in phosphate and vitamin D metabolism (2004) (137)
- A new strategy for large-scale preparation of high-titer recombinant adeno-associated virus vectors by using packaging cell lines and sulfonated cellulose column chromatography. (1996) (133)
- A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein. (2011) (133)
- Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice. (2004) (132)
- Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene. (1989) (131)
- A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus (1992) (125)
- Amplification, up‐regulation and over‐expression of DVL‐1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers (2003) (124)
- Filamin acts as a key regulator in epithelial defence against transformed cells (2014) (124)
- miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability. (2013) (120)
- Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. (1993) (117)
- Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. (1993) (116)
- Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. (1991) (103)
- The role of tissue-nonspecific alkaline phosphatase in the phosphate-induced activation of alkaline phosphatase and mineralization in SaOS-2 human osteoblast-like cells (2008) (101)
- Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences. (2004) (98)
- Alanine scanning mutagenesis of the switch I region in the ATPase site of Dictyostelium discoideum myosin II. (1997) (92)
- A genetically engineered cell line that produces empty capsids of B19 (human) parvovirus. (1989) (91)
- Cyanobacteriochrome SesA Is a Diguanylate Cyclase That Induces Cell Aggregation in Thermosynechococcus*♦ (2014) (90)
- Anti‐FGF‐23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice (2011) (90)
- Factors Governing the Activity In Vivo of Ribozymes Transcribed by RNA Polymerase III (1999) (89)
- Characterization of cyanobacteriochrome TePixJ from a thermophilic cyanobacterium Thermosynechococcus elongatus strain BP-1. (2006) (88)
- Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. (2007) (80)
- MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain (2017) (77)
- Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer (2002) (77)
- Novel missense and frameshift mutations in the tissue-nonspecific alkaline phosphatase gene in a Japanese patient with hypophosphatasia. (1994) (77)
- Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein. (2007) (76)
- Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study. (2005) (76)
- Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. (2004) (75)
- Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. (2011) (72)
- EPLIN is a crucial regulator for extrusion of RasV12-transformed cells (2015) (72)
- Ethnic-related differences in the frequency distribution of genetic polymorphisms in the CYP1A1 and CYP1B1 genes in Japanese and Caucasian populations (2000) (71)
- Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element. (2009) (71)
- Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein. (2011) (70)
- Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys. (2017) (69)
- Universal fluorescent labeling (UFL) method for automated microsatellite analysis. (2002) (67)
- Intronless human dihydrofolate reductase genes are derived from processed RNA molecules. (1982) (66)
- Identification of novel proteins in isolated polyphosphate vacuoles in the primitive red alga Cyanidioschyzon merolae. (2009) (65)
- Genomic organization and expression of the human MSH3 gene. (1996) (64)
- Neuronal specificity of α-synuclein toxicity and effect of Parkin co-expression in primates (2007) (63)
- Autocrinological role of basic fibroblast growth factor on tube formation of vascular endothelial cells in vitro. (1991) (63)
- Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway (2010) (63)
- Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism. (1984) (63)
- Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model (2003) (61)
- siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I. (2014) (61)
- Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells (2014) (61)
- Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture (2000) (60)
- Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors (2011) (60)
- Parkin-Mediated Protection of Dopaminergic Neurons in a Chronic MPTP-Minipump Mouse Model of Parkinson Disease (2011) (59)
- Adeno-associated virus 2-mediated intratumoral prostate cancer gene therapy: long-term maspin expression efficiently suppresses tumor growth. (2005) (58)
- Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriers (2011) (58)
- Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes. (2009) (58)
- Stable integration of human immunodeficiency virus-based retroviral vectors into the chromosomes of nondividing cells. (1998) (58)
- Prolonged Survival and Phenotypic Correction of Akp2−/− Hypophosphatasia Mice by Lentiviral Gene Therapy (2010) (57)
- Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1b. (2008) (55)
- A nonlinear model with competition between prostate tumor cells and its application to intermittent androgen suppression therapy of prostate cancer. (2008) (55)
- Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity. (2014) (55)
- Regulation of the human tissue-nonspecific alkaline phosphatase gene expression by all-trans-retinoic acid in SaOS-2 osteosarcoma cell line. (2005) (54)
- Proteomic characterization of ovarian cancers identifying annexin‐A4, phosphoserine aminotransferase, cellular retinoic acid‐binding protein 2, and serpin B5 as histology‐specific biomarkers (2012) (54)
- Hypophosphatasia: Identification of five novel missense mutations (G507A, G705A, A748G, T1155C, G1320A) in the tissue‐nonspecific alkaline phosphatase gene among Japanese patients (1998) (53)
- Vascular type of Ehlers-Danlos syndrome. (2008) (52)
- Titration of hepatitis B virus infectivity in the sera of pre‐acute and late acute phases of HBV infection: Transmission experiments to chimeric mice with human liver repopulated hepatocytes (2008) (50)
- Mutational Analysis and Functional Correlation With Phenotype in German Patients With Childhood‐Type Hypophosphatasia (2001) (50)
- Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice. (2012) (50)
- Reconstitution of blue-green reversible photoconversion of a cyanobacterial photoreceptor, PixJ1, in phycocyanobilin-producing Escherichia coli. (2006) (49)
- Generation of a Chimeric Mouse Reconstituted with Green Fluorescent Protein-Positive Bone Marrow Cells: A Useful Model for Studying the Behavior of Bone Marrow Cells in Regeneration In Vivo (2003) (48)
- Size and shape of poly(ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy. (1983) (48)
- Contribution of promoter to tissue-specific expression of the mouse immunoglobulin kappa gene. (1985) (47)
- Indiscriminate activity from the B19 parvovirus p6 promoter in nonpermissive cells. (1991) (46)
- Direct Comparison of Administration Routes for AAV8-mediated Ocular Gene Therapy (2013) (46)
- Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice. (2005) (45)
- Serotype-independent method of recombinant adeno-associated virus (AAV) vector production and purification. (2012) (45)
- Adeno-Associated Viral Vector-Mediated Expression of Endostatin Inhibits Tumor Growth and Metastasis in an Orthotropic Pancreatic Cancer Model in Hamsters (2004) (45)
- Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates. (2007) (44)
- Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model (2014) (44)
- Expression of the Mutant (1735T‐DEL) Tissue‐Nonspecific Alkaline Phosphatase Gene from Hypophosphatasia Patients (1998) (43)
- Chondrogenic and osteogenic differentiation of adipose-derived stem cells isolated from GFP transgenic mice. (2004) (43)
- Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface (1996) (43)
- Recent advances in mass spectrometry-based approaches for proteomics and biologics: Great contribution for developing therapeutic antibodies. (2017) (42)
- Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G (2007) (41)
- Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA. (2001) (41)
- Genetic aspects of the vascular type of Ehlers-Danlos syndrome (vEDS, EDSIV) in Japan. (2007) (40)
- Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis. (2014) (40)
- Adeno-associated vector (type 8)-mediated expression of soluble Flt-1 efficiently inhibits neovascularization in a murine choroidal neovascularization model. (2010) (39)
- Rescue of severe infantile hypophosphatasia mice by AAV-mediated sustained expression of soluble alkaline phosphatase. (2011) (39)
- AAV1 mediated co-expression of formylglycine-generating enzyme and arylsulfatase a efficiently corrects sulfatide storage in a mouse model of metachromatic leukodystrophy. (2007) (36)
- Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders (2003) (35)
- Cardiomyocyte Regeneration from Circulating Bone Marrow Cells in Mice (2003) (35)
- Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis (2005) (34)
- Identification of two initiator elements in the bidirectional promoter of the human dihydrofolate reductase and mismatch repair protein 1 genes. (1994) (34)
- Loss of expression of the human MSH3 gene in hematological malignancies. (1995) (34)
- Fully validated LCMS bioanalysis of Bevacizumab in human plasma using nano-surface and molecular-orientation limited (nSMOL) proteolysis. (2016) (34)
- Validated LC-MS/MS analysis of immune checkpoint inhibitor Nivolumab in human plasma using a Fab peptide-selective quantitation method: nano-surface and molecular-orientation limited (nSMOL) proteolysis. (2016) (34)
- Vitamin D receptor-independent FGF 23 actions in regulating phosphate and vitamin D metabolism (2005) (33)
- Long-term correction of biochemical and neurological abnormalities in MLD mice model by neonatal systemic injection of an AAV serotype 9 vector (2014) (33)
- Successful gene therapy in utero for lethal murine hypophosphatasia. (2012) (32)
- Importance of deletion of T at nucleotide 1559 in the tissue-nonspecific alkaline phosphatase gene in Japanese patients with hypophosphatasia (2002) (32)
- A 165-base pair sequence between the dihydrofolate reductase gene and the divergently transcribed upstream gene is sufficient for bidirectional transcriptional activity. (1989) (32)
- Overexpression of GDNF in the uninjured DRG exerts analgesic effects on neuropathic pain following segmental spinal nerve ligation in mice. (2011) (32)
- Functional Characterization of the N-terminal Region of Myosin-2* (2006) (32)
- GH enhances proliferation of human hepatocytes grafted into immunodeficient mice with damaged liver. (2007) (31)
- FIRST‐TRIMESTER PRENATAL MOLECULAR DIAGNOSIS OF INFANTILE HYPOPHOSPHATASIA IN A JAPANESE FAMILY (1996) (31)
- Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno‐associated viral vector serotype 1 (2009) (31)
- XXIV World Allergy Congress 2015 (2016) (31)
- Ehlers-Danlos syndrome type IV with few extrathoracic findings: a newly recognized point mutation in the COL3A1 gene (2002) (30)
- Effect of lysed Enterococcus faecalis FK‐23 (LFK) on allergen‐induced peritoneal accumulation of eosinophils in mice (2003) (30)
- Induction of differentiation of mouse myeloid leukemia cells by poly(ADP-ribose). (1978) (30)
- Lysed enterococcus faecalis FK-23 oral administration reveals inverse association between tuberculin responses and clinical manifestations in perennial allergic rhinitis: a pilot study. (2004) (29)
- Effects of lysed Enterococcus faecalis FK‐23 on allergen‐induced serum antibody responses and active cutaneous anaphylaxis in mice (2004) (29)
- Coexpression of formylglycine-generating enzyme is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy. (2005) (29)
- Long-term inhibition of glycosphingolipid accumulation in Fabry model mice by a single systemic injection of AAV1 vector in the neonatal period. (2009) (29)
- Ex vivo cell-mediated gene therapy for metachromatic leukodystrophy using neurospheres (2006) (29)
- Chromatin structure of the human dihydrofolate reductase gene promoter. Multiple protein-binding sites. (1986) (29)
- Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF (2014) (29)
- Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase. (1999) (29)
- Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. (2003) (28)
- Occurrence of H1o-like protein and protein A24 in the chromatin of bullfrog erythrocytes lacking histone 5. (1981) (28)
- Corrective effect on Fabry mice of yeast recombinant human α-galactosidase with N-linked sugar chains suitable for lysosomal delivery (2006) (26)
- Loss of DCC gene expression is of prognostic importance in acute myelogenous leukemia. (2002) (25)
- Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability (2000) (25)
- Near-triploidy and near-tetraploidy in hematological malignancies and mutation of the p53 gene. (2004) (25)
- Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element. (2009) (24)
- Functional assay of the mutant tissue-nonspecific alkaline phosphatase gene using U2OS osteoblast-like cells. (2008) (24)
- Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor (2021) (24)
- Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene (1997) (24)
- Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation (2016) (24)
- New strategy for in vivo transgene expression in corneal epithelial progenitor cells (2002) (23)
- Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis (2016) (23)
- Dextran sulfate and stromal cell derived factor-1 promote CXCR4 expression and improve bone marrow homing efficiency of infused hematopoietic stem cells. (2009) (23)
- Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells. (2015) (23)
- Potential implications for monitoring serum bile acid profiles in circulation with serum proteome for carbon tetrachloride-induced liver injury/regeneration model in mice. (2010) (23)
- Upstream sequences within the terminal hairpin positively regulate the P6 promoter of B19 parvovirus. (1991) (23)
- Site-specific demethylation and normal chromatin structure of the human dihydrofolate reductase gene promoter after transfection into CHO cells (1987) (23)
- Structural characterization of pyridylaminated oligosaccharides derived from neutral glycosphingolipids by high-sensitivity capillary electrophoresis-mass spectrometry. (2013) (23)
- A human dihydrofolate reductase intronless pseudogene with an Alu repetitive sequence: multiple DNA insertions at a single chromosomal site. (1984) (22)
- Adeno-associated virus-mediated antiapoptotic gene delivery: in vivo gene therapy for neurological disorders. (2002) (22)
- Leukemogenesis of b2a2-type p210 BCR/ABL in a bone marrow transplantation mouse model using a lentiviral vector. (2005) (22)
- Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice (2005) (22)
- Only the promoter region of the constitutively expressed normal and amplified human dihydrofolate reductase gene is DNase I hypersensitive and undermethylated. (1985) (22)
- Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice. (2010) (22)
- Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells. (2010) (22)
- Ehlers–Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis (2001) (22)
- Glycosyltransferase MDR1 assembles a dividing ring for mitochondrial proliferation comprising polyglucan nanofilaments (2017) (22)
- Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene (2012) (22)
- Tissue Inhibitor of Metalloproteinase-2 Suppresses Collagen Synthesis in Cultured Keloid Fibroblasts (2015) (21)
- Effects of phosphates on the expression of tissue-nonspecific alkaline phosphatase gene and phosphate-regulating genes in short-term cultures of human osteosarcoma cell lines (2006) (21)
- Role of Bone Marrow Cells in the Healing Process of Mouse Experimental Glomerulonephritis (2005) (21)
- Natural occurence of a biopolymer, poly (adenosine diphosphate ribose). (1977) (21)
- AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice. (2012) (21)
- Safety and long-term effect of the probiotic FK-23 in patients with hepatitis C virus infection (2016) (20)
- A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging. (2007) (20)
- Production of free methylarginines via the proteasome and autophagy pathways in cultured cells. (2011) (20)
- In vivo targeted gene transfer into liver cells mediated by a novel galactosyl-D-lysine/D-serine copolymer (1999) (20)
- Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9 (2018) (20)
- Effect of lysed Enterococcus faecalis FK-23 on allergen-induced immune responses and intestinal microflora in antibiotic-treated weaning mice. (2007) (20)
- Nine-bp repeat polymorphism in exon 1 of the hMSH3 gene (1995) (20)
- Antibody drug quantitation in coexistence with anti-drug antibodies on nSMOL bioanalysis. (2018) (20)
- Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector (2016) (20)
- A novel strategy of cell targeting based on tissue-specific expression of the ecotropic retrovirus receptor gene. (1998) (20)
- Site-Specific Integration of an Adeno-Associated Virus Vector Plasmid Mediated by Regulated Expression of Rep Based on Cre-loxP Recombination (2000) (20)
- Multistep pathogenesis of leukemia via the MLL-AF4 chimeric gene/Flt3 gene tyrosine kinase domain (TKD) mutation-related enhancement of S100A6 expression. (2009) (19)
- Bone formation following transplantation of genetically modified primary bone marrow stromal cells (2003) (19)
- Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus (2007) (19)
- Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24. (2007) (19)
- Transient cardiomyopathy in a patient with congenital contractural arachnodactyly (Beals syndrome). (2006) (19)
- Two-step gene transfer using an adenoviral vector carrying the CD4 gene and human immunodeficiency viral vectors. (1996) (19)
- Prenatal genetic diagnosis of severe perinatal (lethal) hypophosphatasia. (2007) (19)
- Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector. (2001) (19)
- The multiple hemoglobins of the Japanese eel, Anguilla japonica. Molecular basis for hemoglobin multiplicity and the subunit interactions. (1980) (18)
- Perinatal hypophosphatasia caused by uniparental isodisomy. (2014) (18)
- Glucocerebrosidase level in the cerebrospinal fluid during enzyme replacement therapy – unsuccessful treatment of the neurological abnormality in type 2 Gaucher disease (2003) (18)
- A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging (2007) (17)
- Beneficial effects of heat-treated Enterococcus faecalis FK-23 on high-fat diet-induced hepatic steatosis in mice (2014) (17)
- Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma (2012) (17)
- Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice (2013) (16)
- In vivo application of an RNAi strategy for the selective suppression of a mutant allele. (2011) (16)
- Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector. (2001) (16)
- The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors. (2013) (16)
- Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles. (2011) (16)
- Purified GPI-anchored CD4DAF as a receptor for HIV-mediated gene transfer. (1994) (16)
- Differential characteristics of HIV-based versus SIV-based lentiviral vector systems: Gene delivery to neurons and axonal transport of expressed gene (2007) (15)
- Enhancement of anti-allergic effects mediated by the Kampo medicine Shoseiryuto (Xiao-Qing-Long-Tang in Chinese) with lysed Enterococcus faecalis FK-23 in mice. (2010) (15)
- Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study (2015) (15)
- The development of the validated LCMS bioanalysis of trastuzumab in human plasma using a selective detection method for complementarity-determining regions of monoclonal antibodies: nano-surface and molecular-orientation limited (nSMOL) proteolysis (2015) (15)
- Validated LC/MS Bioanalysis of Rituximab CDR Peptides Using Nano-surface and Molecular-Orientation Limited (nSMOL) Proteolysis. (2016) (15)
- Essential Role of the A’α/Aβ Gap in the N-Terminal Upstream of LOV2 for the Blue Light Signaling from LOV2 to Kinase in Arabidopsis Photototropin1, a Plant Blue Light Receptor (2015) (15)
- Structural characterization of neutral glycosphingolipids using high-performance liquid chromatography-electrospray ionization mass spectrometry with a repeated high-speed polarity and MSn switching system (2013) (14)
- Transduction of retrovirus-mediated NeoR gene into CD34+ cells purified from granulocyte colony-stimulating factor (G-CSF)-mobilized infant and cord blood. (1997) (14)
- Adenoviral mediated MyoD gene transfer into fibroblasts: Myogenic disease diagnosis (2006) (14)
- LC–MS bioanalysis of Trastuzumab and released emtansine using nano‐surface and molecular‐orientation limited (nSMOL) proteolysis and liquid–liquid partition in plasma of Trastuzumab emtansine‐treated breast cancer patients (2017) (14)
- Identification of a novel frameshift mutation (383insT) in the RUNX2 (PEBP2 α/CBFA1/AML3) gene in a Japanese patient with cleidocranial dysplasia (2001) (13)
- AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice. (2007) (13)
- In situ Gene Transfer and Suicide Gene Therapy of Gastric Cancer Induced by N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Dogs (1999) (13)
- Multiplexed monitoring of therapeutic antibodies for inflammatory diseases using Fab-selective proteolysis nSMOL coupled with LC-MS. (2019) (13)
- Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1. (1996) (13)
- Purification and Characterization of Cold-Adapted Metalloprotease from Deep Sea Water Lactic Acid Bacteria Enterococcus Faecalis TN-9 (2009) (13)
- Direct Comparison of Four Adeno-Associated Virus Serotypes in Mediating the Production of Antiangiogenic Proteins in Mouse Muscle (2011) (13)
- Development of iodoacetic acid-based cysteine mass tags: detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. (2012) (13)
- Posttranscriptional modulation of the human tissue–nonspecific alkaline phosphatase gene expression by 1,25-dihydroxyvitamin D3 in MG-63 osteoblastic osteosarcoma cells (2006) (13)
- Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model. (2019) (13)
- A double‐blind, placebo‐controlled evaluation of orally administered heat‐killed Enterococcus faecalis FK‐23 preparation in atopic dogs (2019) (12)
- Suicide Gene Therapy for Chemically Induced Rat Bladder Tumor Entailing Instillation of Adenoviral Vectors (2001) (12)
- The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide‐associated complex Egd2 under stress conditions (2009) (12)
- Complete Genome Sequence of Bacteriophage BC-611 Specifically Infecting Enterococcus faecalis Strain NP-10011 (2012) (12)
- Spontaneous Colon Perforations Associated with a Vascular Type of Ehlers-Danlos Syndrome (2014) (12)
- Gene therapy improves dental manifestations in hypophosphatasia model mice (2017) (12)
- FGF23 as a novel therapeutic target. (2012) (12)
- NovelTranscription MapfortheB19(Human) Pathogenic Parvovirus (1987) (12)
- Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model (2012) (12)
- Cloning of the mitochondrial genome of Rana catesbeiana and the nucleotide sequences of the ND2 and five tRNA genes. (1988) (11)
- Linkage between the distribution of mutations in the CYP2C18 and CYP2C19 genes in the Japanese and Caucasian. (1998) (11)
- Comparison of Bevacizumab Quantification Results in Plasma of Non-small Cell Lung Cancer Patients Using Bioanalytical Techniques Between LC-MS/MS, ELISA, and Microfluidic-based Immunoassay (2019) (11)
- Application of nSMOL coupled with LC‐MS bioanalysis for monitoring the Fc‐fusion biopharmaceuticals Etanercept and Abatacept in human serum (2018) (11)
- Effects of a fermented vegetable product on fat deposition and bone metabolism in ovariectomized rats. (2004) (10)
- Application of nano-surface and molecular-orientation limited proteolysis to LC-MS bioanalysis of cetuximab. (2016) (10)
- Surgical Specimens of Colorectal Cancer Fixed with PAXgene Tissue System Preserve High-Quality RNA. (2015) (10)
- Administration of live, but not inactivated, Faecalibacterium prausnitzii has a preventive effect on dextran sodium sulfate‑induced colitis in mice. (2019) (10)
- Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice (2021) (10)
- A Novel Isolation Technique of Progenitor Cells in Human Corneal Epithelium Using Non‐Tissue Culture Dishes (2008) (10)
- Hematopoiesis in Regenerated Bone Marrow Within Hydroxyapatite Scaffold (2010) (10)
- Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors. (2007) (10)
- Effect of water-soluble fraction from lysozyme-treated Enterococcus faecalis FK-23 on mortality caused by influenza A virus in mice. (2012) (10)
- Geographic and seasonal variations of the number of B chromosomes and external morphology in Psathyropus tenuipes (Arachnida: Opiliones) (2004) (10)
- HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia (2007) (9)
- Identification of an RNA fraction from Enterococcus faecalis FK-23 cells as the antihypertensive compound (1996) (9)
- Immunomodulation effects of heat-treated Enterococcus faecalis FK-23（FK-23） in mice (2009) (9)
- Sequential Histopathological Changes in vivo after Suicide Gene Therapy of Gastric Cancer Induced by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in Rats (2001) (9)
- Effects of Enterococcus sp. isolated from deep seawater on inhibition of allergic responses in mice (2008) (9)
- A novel missense mutation and frameshift mutations in the type II receptor of transforming growth factor-beta gene in sporadic colon cancer with microsatellite instability. (1998) (9)
- Accumulation of the myosin‐II‐spectrin complex plays a positive role in apical extrusion of Src‐transformed epithelial cells (2018) (9)
- Transduction of fibroblasts and CD34+ progenitors using a selectable retroviral vector containing cDNAs encoding arylsulfatase A and CD24 (2000) (9)
- Frameshift Mutations and a Length Polymorphism in the hMSH3 Gene and the Spectrum of Microsatellite Instability in Sporadic Colon Cancer (1999) (9)
- Cyclical mechanical stretch enhances degranulation and IL‐4 secretion in RBL‐2H3 mast cells (2014) (9)
- Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes. (1987) (9)
- Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein (2015) (9)
- Ehlers‐Danlos syndrome, vascular type: A novel missense mutation in the COL3A1 gene (2012) (8)
- Evaluation of a Cytokine Combination Including Thrombopoietin for Improved Transduction of a Retroviral Gene into G‐CSF‐Mobilized CD34+ Human Blood Cells (1997) (8)
- Relation between microsatellite instability and N‐ras mutation and duration of disease free survival in patients with acute leukemia (1998) (8)
- A novel mutation screening system for Ehlers-Danlos Syndrome, vascular type by high-resolution melting curve analysis in combination with small amplicon genotyping using genomic DNA. (2011) (8)
- [Gene therapy using retroviral vectors]. (2003) (8)
- Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model (2014) (8)
- Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice (2014) (8)
- Multi epitope-targeting immunoprecipitation using F(ab') fragments with high affinity and specificity for the enhanced detection of a peptide with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. (2013) (8)
- Improved methods of HIV vector mediated gene transfer. (1998) (8)
- Adeno-associated viral vector-mediated gene transduction in mesencephalic slice culture (2011) (7)
- Genetic diagnosis of Werdnig-Hoffmann disease: a problem for application to prenatal diagnosis. (2003) (7)
- Ehlers–Danlos type IV in pregnancy with a history of myocardial infarction (2009) (7)
- Nutrition education in medical schools in Japan: results from a questionnaire survey. (2006) (7)
- Flexible antibodies with nonprotein hinges (2011) (7)
- Apoptotic Cell Death and Regeneration in the Newborn Retina After Irradiation Prior to Bone Marrow Transplantation (2007) (7)
- Hematopoiesis in regenerated bone marrow within hydroxyapatite scaffold. (2010) (7)
- Effects of neutral salts and alcohols on the activity of Streptomyces caespitosus neutral protease. (2007) (7)
- Purification and Characterization of Bullfrog Serum α1-Glycoprotein (1973) (7)
- Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection (2013) (7)
- Multiplex LCMS Bioanalysis of Brentuximab Vedotin, Rituximab and Cetuximab towards Therapeutic Drug Monitoring Application by Combined Calibration Curve Using Fab-Selective Limited Proteolysis nSMOL (2016) (7)
- Adipose‐derived stromal cells grown on a hydroxyapatite scaffold can support hematopoiesis in regenerated bone marrow in vivo (2014) (6)
- Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl (2005) (6)
- Positron emission tomography imaging of renal mitochondria is a powerful tool in the study of acute and progressive kidney disease models. (2020) (6)
- Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. (2000) (6)
- Verification between Original and Biosimilar Therapeutic Antibody Infliximab Using nSMOL Coupled LC-MS Bioanalysis in Human Serum (2018) (6)
- Acceleration of nano‐surface and molecular‐orientation limited (nSMOL) proteolysis with acidified reduction pretreatment for quantification of Tocilizumab (2019) (6)
- Fauna and biogeography of harvestmen (Arachnida: Opiliones) of the Oki Islands, Japan (2005) (6)
- Further characterization of bullfrog serum albumin. (1973) (6)
- Effects of lysed Enterococcus faecalis FK-23 on allergen-induced peritoneal accumulation of eosinophils and serum total IgE concentration in inbred mice. (2008) (6)
- Identification of the protein components of mismatch binding complexes in human cells using a gel‐shift assay (1999) (5)
- Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models (2005) (5)
- Use of an alternative signature peptide during development of a LC-MS/MS assay of plasma nivolumab levels applicable for multiple species. (2020) (5)
- Hematopoietic capacity of preterm cord blood hematopoietic stem/progenitor cells. (2009) (5)
- 618. A Novel Gene Therapy Strategy for Vascular Ehlers-Danlos Syndrome by the Combination with RNAi Mediated Inhibition of a Mutant Allele and Transcriptional Activation of a Normal Allele (2005) (5)
- Differential susceptibilities of DNA polymerases-αand -βto polyanions (1978) (5)
- A simple and efficient purification of transduced cells by using green fluorescent protein gene as a selection marker (1998) (5)
- An asymptomatic heterozygous female with fabry disease: implications for enzyme replacement therapy. (2005) (5)
- In situ screening for postsynaptic cell adhesion molecules during synapse formation (2017) (5)
- Carbonylation of Formaldehyde with Carbon Monoxide over Cation-Exchange Resin Catalysts (1999) (5)
- Purification to Homogeneity of a Neutral Metalloproteinase from Streptomyces caespitosus (2007) (5)
- Recipient non-hematopoietic bone marrow cells in the intestinal graft after fetal small intestinal transplantation (2004) (4)
- Targeted gene delivery to selected liver segments via isolated hepatic perfusion. (2010) (4)
- Chimeric mice with human hepatocytes: A new system for genotoxicity studies. (2019) (4)
- Increase in serum albumin during bullfrog metamorphosis. (1973) (4)
- Presymptomatic genetic analysis during pregnancy for vascular type Ehlers–Danlos syndrome (2014) (4)
- Trial of Antisense RNA Inhibition of HIV Replication and Gene Expression (1991) (4)
- Home treatment with enzyme replacement therapy in a 5‐year‐old girl with type 2 Gaucher disease (2003) (4)
- Targeted and stable gene delivery into muscle cells by a two-step transfer system. (2000) (4)
- Bone Marrow Regeneration Using Adipose-Derived Stem Cells (2006) (4)
- [Gene transfer into non-dividing cells by a lentiviral vector]. (1997) (3)
- Gene profiling and bioinformatics analyses reveal time course differential gene expression in surgically resected colorectal tissues (2014) (3)
- Mutations in p53 cDNA sequence introduced by retroviral vector. (2006) (3)
- Regulated LC-MS/MS bioanalysis technology for therapeutic antibodies and Fc-fusion proteins using structure-indicated approach. (2019) (3)
- Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance (2021) (3)
- Direct antigen detection from immunoprecipitated beads using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; a new method for immunobeads-mass spectrometry (iMS). (2011) (3)
- In vivo gene transfer into corneal epithelial progenitor cells by viral vectors. (2000) (3)
- A retroviral vector capable of targeted gene transfer into cells expressing HIV envelope glycoprotein. (2000) (3)
- Comparison of Stem Cells Harvested from Adipose Tissue and Bone Marrow. (2005) (3)
- Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors (2015) (3)
- Application of Enterococcus Faecalis FK-23 in Fattening of the Japanese Black Cattle (2009) (3)
- Recombinant adeno-associated virus-mediated gene delivery to the central nervous system. (2007) (3)
- Magnesium and Osteoporosis (2007) (3)
- Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A (2021) (3)
- Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan (2020) (3)
- Improved intravitreal AAV-mediated inner retinal gene transduction by surgical internal limiting membrane (ILM) peeling in cynomolgus monkeys (2017) (2)
- HIV-mediated expression of Btk in hematopoietic stem cells is not sufficient to restore B cell function in X-linked immunodeficient mice. (2005) (2)
- Physics: A tabletop neutron source (2013) (2)
- A rapid and sensitive assay system for bacterial gpt activity in transfected mammalian cells. (1987) (2)
- Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection (2021) (2)
- Current status and future prospects of human gene therapy (1996) (2)
- PRENATAL DIAGNOSIS OF STEROID 21‐HYDROXYLASE DEFICIENCY BY ANALYSIS OF POLYMERASE CHAIN REACTION–SINGLE STRAND CONFORMATION POLYMORPHISM (PCR–SSCP) PROFILES (1997) (2)
- [Anti-allergic effects of the probiotic preparations of enterococcus on experimental allergic rhinitis in mice]. (2013) (2)
- Effect of first-trimester ultrasound examination for chromosomal aberrations in women undergoing amniocentesis. (2006) (2)
- Improvement of Vaccination Effect on Ocellate Puffer and Japanese Flounder by the Feeding of Artificial Feed with Heat-killed Enterococcus faecalis FK-23 (2008) (2)
- Perinatal (Lethal) Type Of Hypophosphatasia Resulting From Paternal Isodisomy Of Chromosome 1 (2012) (2)
- Prenatal Diagnosis of Severe Perinatal (Lethal) Hypophosphatasia (2012) (2)
- Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia. (2021) (2)
- Systems-Based Approach to Drug Response (2013) (1)
- Rescue of Lethal Hypophosphatasia Mice by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells. (2012) (1)
- Orthotropic Pancreatic Cancer Model in Hamsters Endostatin Inhibits Tumor Growth and Metastasis in an Adeno-Associated Viral Vector-Mediated Expression of Updated (2004) (1)
- Possible Roles of Fibroblast Growth Factor 23 in Developing X-Linked Hypophosphatemia (2005) (1)
- [Suicide genes for gene therapy]. (1995) (1)
- G317D mutation in the tissue-nonspecific alkaline phosphatase gene associated with childhood hypophosphatasia in a German family (2002) (1)
- MLL/AF4 Positive Acute Lymphoblastic Leukemia Has Resistance to Tumor Necrosis Factor-Alpha Caused by up-Regration of S100A6 (2010) (1)
- A novel point mutation in type III collagen gene resulting in exon 24 skipping in a case of vascular type Ehlers-Danlos syndrome (2008) (1)
- Selective Transduction of HIV-1-Infected Cells by the Combination of HIV and MMLV Vectors (2001) (1)
- Neonatal Gene Therapy for Inherited Disorders (2017) (1)
- 96. Enforced HoxB4 Expressed Hematopoietic Stem Cells Transdifferentiate into Oligodendrocytes in Adult Mouse Brain (2006) (1)
- Developmental changes in non-histone chromosomal proteins of bullfrog (Rana catesbeiana). (1982) (1)
- [Present status and future prospects of human gene therapy]. (1993) (1)
- The DCC Heterozygote Reduces the Latency Period and Changes the Disease Phenotype of Myeloproliferative Disease in p230BCR/ABL-Expressing Mice. (2004) (1)
- Bone Marrow Cell Based Enzyme Replacement Prolongs Survival and Improves Disease Phenotypes In a Mouse Model Of Lethal Hypophosphatasia (2013) (1)
- [Gene transfer using adeno-associated virus (AAV) vectors]. (1997) (1)
- STUDIES ON ABNORMALITIES OF GLUCURONIDATION IN CARCINOMA HOSTS (1968) (1)
- Differential susceptibilities of DNA polymerases-alpha and -beta to polyanions. (1978) (1)
- Inhibitory Effect of Moringa Leaf on Cedar Pollen-induced Eosinophil Accumulation in Mice (2011) (1)
- EFFECTS OF PRESTORAGE LEUKOCYTE REDUCTION IN ENDOTOXIN-CONTAMINATED AUTOLOGOUS BLOOD (2004) (1)
- Development and Application of HIV Vectors Pseudotyped with HIV Envelopes (2011) (1)
- The Activated K-RAS Protein Accelerates Human Derived-MLL/AF4 Induced Leukemo-Lymphomogenicity In Transgenic Mice Model (2010) (1)
- Remedy for rosacea (1998) (0)
- 160. Successful Treatment of Neonatal Metachromatic Leukodystrophy Model Mice by Low Dose of Self-Complementary AAV Type9 Vector Expressing ASA (2016) (0)
- [Anti-HIV genes: strategies for gene therapy of AIDS]. (1993) (0)
- [Current status and prospects for the education of medical genetics]. (2010) (0)
- 242. The Use of AAV Serotype 1 Vector for Expression of |[alpha]|-Galactosidase A in Fabry Knockout Mice (2005) (0)
- Hematopoiesis in Bone Marrow Regenerated from Adipose-Derived Stromal Cells. (2007) (0)
- Neonatal Gene Therapy for Inherited Disorders Neonatal Gene Therapy for Inherited Disorders (2018) (0)
- 407. A Single Unilateral Injection of AAV1-ASA and AAV1-FGE Vectors into the Hippocampus Results in Bilateral Expression and Widespread Distribution of ASA and Prevention of Sulfatide Storage in the Whole Brain of MLD Model Mice (2006) (0)
- Regeneration of Hematopoietic Microenvironment (Bone Marrow) Using Adipose-Derived Stem Cells - The 2nd Report. (2005) (0)
- 1071. Potential Utility of Adipose-Derived Stromal Cells (ASCs) as a Carrier for Ex Vivo Gene Therapy |[ndash]| Gene Transfer Efficiency of ASCs (2005) (0)
- [Gene transfer using recombinant HIV vectors]. (1995) (0)
- [Progress in targeted gene repair]. (2001) (0)
- [Ethical problems in gene medicine]. (2001) (0)
- Regeneration of Bone Marrow from Adipose-Derived Stromal Cells - a Novel Approach for the Treatment of Fibroblastic Bone Marrow Diseases. (2004) (0)
- 469. Optimization of the Lentivirus Vector Containing the MSCV-U3 and EF1α Double Internal Promoters (2006) (0)
- [Possible role of the FGF23-Klotho axis in bone mineralization]. (2007) (0)
- 554. Efficient Scalable Purification of rAAV1 Using Ion-Exchange and Gel-Filtration Chromatography To Avoid Ultracentrifugation Procedure (2015) (0)
- 968. Co-Expression of FGE Is Essential for Gene Therapy of MLD Based on Cross-Correction of ASA Deficiency (2005) (0)
- 94 An asymptomatic heterozygous female with Fabry disease: Implications for enzyme replacement therapy (2007) (0)
- 308. Ultracentrifugation-Free Chromatography-Mediated Large-Scale Purification of Recombinant Adeno-Associated Virus Serotype 1 (rAAV1) and rAAV9 from the Serum-Free Culture Supernatant (2016) (0)
- [Development of new virus vectors for gene therapy]. (1994) (0)
- 2 Prenatal Diagnosis of Severe Perinatal ( Lethal ) Hypophosphatasia (2012) (0)
- Chondrogenic and Osteogenic Differentiation of Adipose Tissue‐Derived Stem Cells Isolated from GFP Transgenic Mice (2005) (0)
- 866. Modification of the expression vector for systemic gene therapy of MLD (2004) (0)
- HUMAN-SPECIFIC METABOLITE IN DICLOFENAC-TREATED CHIMERIC PXB MICE WITH HIGHLY HUMANIZED LIVER (2010) (0)
- Prognostic impact of platelet-derived growth factor in breast carcinoma patients with hematogenous metastasis (2000) (0)
- The 15th Annual Meeting 2009 Japan Society of Gene Therapy (2010) (0)
- MD Simulation of Ribosome Jam (2010) (0)
- Bulk ACCVD Generation of SWNTs with Narrow Chirality Distribution (2005) (0)
- Intronless humandihydrofolate reductase genesarederived from processed RNAmolecules (1982) (0)
- EFFECT OF CNTNAP2 POLYMORPHISMS ON CEREBRAL RESPONSE TO HUMAN VOICE PERCEPTION AND HANDEDNESS: AN FMRI STUDY (2015) (0)
- COMPARISON OF THE GENE TRANSFER EFFICIENCY OF MESENCHYMAL STEM CELLS HARVESTED FROM MURINE FAT AND BONE MARROW (2006) (0)
- [Human gene therapy]. (1996) (0)
- 311. Targeted Gene Delivery to Selected Liver Segments by Isolated Hepatic Perfusion with Clamping of the Portal Vein (2004) (0)
- 707. Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice By Adeno-Associated Virus-Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase (2015) (0)
- Biomarkers to predict the efficacy of Infliximab in the Patients with Inflammatory Bowel Disease (2018) (0)
- Therapeutic effects of bone marrow transplantation for metachromatic leukodystrophy using HOXB4 over-expressing cells (2008) (0)
- 48. Adeno-Associated Viral (AAV) Vector- Mediated Systemic Delivery of mda-7/IL24 Inhibits Tumor Growth by Antitumor Bystander Effect (2006) (0)
- Tyrosine-mutated AAV2 mediated BDNF gene therapy attenuates retinal ischemic injuries in rats (2014) (0)
- Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells (2013) (0)
- Advances in parkin gene therapy—A primate study (2007) (0)
- Klotho is an essential molecule responsible for tissue specific FGF23 signaling (2006) (0)
- [Highly sensitive enzyme-linked immunosorbent assay for the quantification of allergens from Dermatophagoides, DER p 1 and DER f 1]. (2010) (0)
- Glycosyloted Hb in Childhood (1980) (0)
- 1060. The MSCV_U3 Internal Promoter Strongly Activates Surrounding Cellular Promoter in Combination with Self_Inactivating (SIN)_MSCV Vector Backbone (2006) (0)
- [Updates on rickets and osteomalacia: anti-FGF23 antibody, a new therapeutic approach for hypophosphatemic rickets/osteomalacia]. (2013) (0)
- Suicide gene therapy for bladder tumors. (2001) (0)
- Risk of single low dose irradiation for developing retina and contribution of bone marrow cells to injured retinal tissue (2004) (0)
- MLL-AF4 and FLT3 Activation Synergize To Induce Multi Step Leukemogenesis. (2006) (0)
- Root-Gutteridge, H.A.J. & Chatterjee, H.J. Purification and Characterization of Cold-Adapted Metalloprotease from Deep Sea Water Lactic Acid Bacteria Enterococcus Faecalis TN-9 12 (2009) (0)
- Abstract 2962: Development of the LCMS bioanalysis for clinical pharmacokinetics of antibody drugs using Fab-selective limited proteolysis (nSMOL) (2016) (0)
- 93. Diminished Mobilization of Self-Inactivating (SIN) Lentiviral Vectors Containing Globin Regulatory Elements Compared to Those Containing a Retroviral Long Terminal Repeat (2005) (0)
- 996. Direct Comparison of Adeno-Associated Virus (AAV) Serotypes for Muscle Expression of Soluble Anti-Angiogenic Proteins (2006) (0)
- The Clinical Features and Prognostic Impact of DNMT3A Gene Mutation in Japanese Patients with De Novo AML (2011) (0)
- 13 Local and systemic gene therapy for metachromatic leukodystrophy (2007) (0)
- [Cell-mediated gene therapy using bone marrow derived cells towards regenerative medicine]. (2003) (0)
- Neuron-specific gene transfer system through retrograde transport of lentiviral vector for the study of structure and function of brain neural circuit (2011) (0)
- Gene therapy of MLD model mice by intrathecal and intravenous injection of AAV9 vector (2014) (0)
- 3. Effects of the cHS4 Insulator Elements on Transgene Expression and Biological Titer of Lentiviral Vector (2005) (0)
- SHRINKAGE OF VITREOUS BODY CAUSED BY HYDROXYL RADICAL (2008) (0)
- In vitro-expanded hepatic progenitor cells-repopulated humanized mouse model for human HBV infection (2008) (0)
- [Current status and problems in human gene therapy]. (2000) (0)
- Comprehensive proteomic studies on ovarian cancer and biomarker discovery for molecular tumor typing (2007) (0)
- Population Dynamics and Evolution of B Chromosomes (2004) (0)
- Hematopoiesis in Regenerated Bone Marrow on the Hydroxyapatite Scaffold. (2007) (0)
- Ex Vivo Gene Therapy Of Severe Infantile Hypophosphatasia Model Mice Using Lentiviral Transduced Bone Marrow Cells (2012) (0)
- Clinical Genetics Education Program in Medical School : A Trial in Nippon Medical School (2007) (0)
- Development of LCMS-Based Fully Validated Bioanalysis of CDR Peptides in Antibody Drugs by Fab-Selective Proteolysis : nSMOL Protocol (2016) (0)
- 865. An Ex Vivo Gene Therapy Approach for Metachromatic Leukodystrophy Using Neural Progenitor Cells (2004) (0)
- Binding Protein to PhyA in Etiolated Seedlings of Pea ; Binding to Endogenous PhyA (1998) (0)
- 31 Effect of cntnap2 polymorphisms on cerebral response to human voice perception and handedness: an fmri study (2017) (0)
- The Use of Hoechst Staining To Identify Hematopoietic and Other Adult Stem Cells. (2006) (0)
- Gene Therapy For Lethal Murine Hypophosphatasia (2012) (0)
- Halophilic vibrios pathogenic for humans (2002) (0)
- Influenza Fusogenic Peptide in DNA Complex Enhances Asialoglycoprotein Receptor-Mediated Gene Transfer to Hepatoma Cells (1997) (0)
- A BlockinFull-Length Transcript Maturation inCells Nonpermissive forB19Parvovirus (1992) (0)
- nSMOL-Development of novel LCMS bioanalytical approach by Fab-selective quantitation of monoclonal antibodies using nano-surface and molecular orientation limited proteolysis (2016) (0)
- Bone Marrow Cells Migrated into the Retinal Tissue of the Newborn Mice and Differentiated into Retinal Cells (2003) (0)
- [Overview: gene transfer techniques]. (1995) (0)
- Gene Delivery and Expression Series Viral Vector Mediated Gene Delivery and Expression ( 5 ) (2012) (0)
- Purification and characterization of bullfrog serum alpha 1-glycoprotein. (1973) (0)
- [Current status and future prospects of molecular medicine]. (1995) (0)
- Effects of site-directed GDNF overexpression on mechanical allodynia in a neuropathic pain model (2009) (0)
- SEARCH FOR PROTEINS ASSOCIATING WITH PHYTOCHROME. (1996) (0)
- Effect of lysed Enterococcus faecalis FK-23 (LFK) on intestinal microflora in antibiotic treated mice (2007) (0)
- Development of an In Vivo Exon Trapping Vector System To Detect Insertional Gene Activation by Lentiviral Vector. (2005) (0)
- 86. Mutation Frequency of the p53 cDNA Introduced by the Retroviral Vector (2004) (0)
- [Physical modalities for arthritis]. (1998) (0)
- THE PHOSPHORIC METABOLISM, THE CALCIUM METABOLISM, CALCIFICATION AND VITAMIN D METABOLISM CHECKED IN POLYPEPTIDES AND FOR THIS CODING DNA Molecules (2001) (0)
- 760 Trough levels of ipilimumab in serum as a potential predictive biomarker of clinical outcomes for patients with advanced melanoma after treatment with ipilimumab (2020) (0)
- Hematopoiesis in Regenerated Bone Marrow on the Hydroxyapatite Scaffold (2008) (0)
- [Clinical aspect of recent progress in phosphate metabolism. FGF23; physiological action and molecular mechanism in the regulation of phosphate and vitamin D metabolism]. (2009) (0)
- [Present status and future prospects of human gene therapy]. (1993) (0)
- Development of Muscle-Directed Systemic Cancer Gene Therapy (2013) (0)
- Establishment and Characterization of A New Leukemia Mouse Model Induced by MLL/AF4 Fusion Protein. (2009) (0)
- Binding Proteins to Phytochrome A in Etiolated Pea Seedlings (1999) (0)
- Insertion of the 1.2kb Chicken β-Globin 5′HS4 Insulator Element in the LTR Inhibits HIV-1 Vector Mediated Transduction at the Early Infection Step. (2007) (0)
- 2P360 Light-induced conformational changes in LOV2-kinase polypeptide of Arabidopsis phototropin 1, a blue light sensor(Photobiology-vision and photoreception,Poster Presentations) (2007) (0)
- Diminished Mobilization of Self-Inactivating (SIN) Lentiviral Vectors Containing Globin Regulatory Elements Compared to Those Containing a Retroviral Long Terminal Repeat. (2004) (0)
- HIV Vector Mediated Gene Transfer into CD4 Positive Cells (1998) (0)
- A Single Intramuscular Injection of AAV-8 Vector Expressing MDA7/IL-24 Efficiently Suppresses Tumor Growth Mediated by Multiple Anti-Cancer Mechanisms In Lymphoma Model Mice. (2010) (0)
- Problem and present state of gene therapy. (1997) (0)
- Antibodies to fibroblast growth factor 23 (2003) (0)
- [Importance and practice of UGT1A1 polymorphisms]. (2012) (0)
- Polypeptides that control metabolism of phosphoric acid, calcium metabolism, calcification metabolism and vitamin D and DNA molecules encoding them. (2001) (0)
- Gene Mutations in Paired Initial Presentation and Relapse Samples From Acute Myeloid Leukemia Patients (2011) (0)
- 443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response (2020) (0)
- Targeted Gene Transfer into CD4 Positive Cells by HIV-Based Retroviral Vectors (1996) (0)
- HIV Vector Mediated Expression of Angiostatin Efficiently Inhibits Neovascularization in a Murine Proliferative Retinopathy Model (2002) (0)
- Safety assessment of lysozyme-and heat-treated Enterococcus faecalis FK-23 (LFK) in healthy and mild hypertensive adult volunteers (2007) (0)
- Hematopoietic Microenvironment Regeneration Using Adipose-Derived Stem Cells. (2006) (0)
- Case Report: A Case of Moyamoya Syndrome Associated With Multiple Endocrine Neoplasia Type 2A (2021) (0)
- Identification of gene expression profiling associated with angiogenesis in human retinal endothelial cells compared with different endothelial cells. (2004) (0)
- Anti-Apoptotic Therapy for Parkinson’s Disease: Overexpression of an APAF-1-Dominant-Negative Inhibitor Can Block MPTP Toxicity (2002) (0)
- Development of the LCMS bioanalysis for antibody drug monitoring in plasma using Fab-selective limited proteolysis (nSMOL) (2015) (0)
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What Schools Are Affiliated With Takashi Shimada?
Takashi Shimada is affiliated with the following schools:
