Takashi Sugimura

Q: What Schools Are Affiliated With Takashi Sugimura

Takashi Sugimura is affiliated with the following schools: Hokkaido University, University of Shizuoka, Osaka Metropolitan University, Niigata University, University of Tokyo, Toho University, Kyoto Women's University, Sapporo Medical University, Mie University, Japan Women's University, Yokohama National University

Takashi Sugimura's AcademicInfluence.com Rankings

Takashi Sugimura

Biology

#710

World Rank

#1235

Historical Rank

Biochemistry

#90

World Rank

#118

Historical Rank

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Biology

Takashi Sugimura's Degrees

PhD Biochemistry University of Tokyo

Why Is Takashi Sugimura Influential?

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According to Wikipedia, was a Japanese biochemist, famous for research on chemical carcinogens. He received the Japan Prize for the contribution to establishment of fundamental concept on causes of cancer. He was elected as President of the Japan Academy on October 15, 2013, serving till 2016 and was replaced with Hiroshi Shiono.

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Takashi Sugimura's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. (1990) (1202)
Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer (2002) (1064)
High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk (2006) (610)
Mutagenicities of N-nitrosamines on Salmonella. (1977) (604)
A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (1991) (575)
Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish (2004) (574)
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. (1988) (569)
Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. (1987) (530)
Food-derived mutagens and carcinogens. (1992) (448)
AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO (1986) (402)
Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. (1985) (387)
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. (1997) (385)
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. (2002) (384)
Mutagens-carcinogens in foods. (1983) (382)
Nutrition and dietary carcinogens. (2000) (375)
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. (1999) (372)
Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. (1994) (370)
Mutagenicities of smoke condensates and the charred surface of fish and meat. (1977) (362)
Tumour Production in Glandular Stomach of Rat by N-Methyl-N′-Nitro-N-Nitrosoguanidine (1967) (342)
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. (1985) (338)
Frequent association of p53 gene mutation in invasive bladder cancer. (1992) (338)
C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment (1984) (336)
A simple and rapid method for generating a deletion by PCR. (1991) (323)
Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea (1987) (310)
Overview of carcinogenic heterocyclic amines. (1997) (310)
Carcinogenicities of heterocyclic amines in cooked food. (1991) (309)
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. (1990) (306)
Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. (1989) (282)
Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. (1986) (277)
Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. (1988) (276)
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes. (1999) (275)
cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. (1987) (271)
Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products (1977) (267)
Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis‐like state in BHK21 cells. (1990) (264)
Quantification of genistein and genistin in soybeans and soybean products. (1996) (256)
Multistep carcinogenesis: a 1992 perspective. (1992) (251)
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. (1988) (251)
Environmental mutagens and carcinogens. (1978) (251)
Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis. (1991) (247)
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes. (1990) (242)
Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures. (1984) (233)
Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. (1987) (229)
Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques (1990) (229)
Frequent loss of heterozygosity at the DCC locus in gastric cancer. (1992) (226)
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters. (1981) (224)
Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. (1980) (222)
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA. (1990) (220)
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. (1983) (219)
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. (1998) (217)
Studies on environmental chemical carcinogenesis in Japan. (1986) (202)
Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. (1989) (201)
Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors. (1997) (200)
Frequent allelic losses and mutations of the p53 gene in human ovarian cancer. (1991) (199)
Mutagenicities of quinoline and its derivatives. (1977) (196)
New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1987) (193)
Enhancement of colon carcinogenesis by prostaglandin E2 administration. (2003) (193)
Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1989) (189)
Identification of silencing of nine genes in human gastric cancers. (2002) (189)
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. (1990) (185)
Carcinogenic action of 4-nitroquinoline-N-oxide. (1957) (184)
Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation. (1991) (182)
Mutagenicity of Flavone Derivatives (1977) (180)
Exposure to heterocyclic amines. (1993) (179)
Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract. (1984) (179)
Mutagenicities of 61 flavonoids and 11 related compounds. (1981) (178)
Identification of Members of the Protein Phosphatase 1 Gene Family in the Rat and Enhanced Expression of Protein Phosphatase 1α Gene in Rat Hepatocellular Carcinomas (1990) (176)
Carcinogenicity examination of quercetin and rutin in ACI rats. (1981) (176)
High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas. (1989) (174)
Human ret proto-oncogene mapped to chromosome 10q11.2. (1989) (173)
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. (2000) (173)
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. (2000) (173)
Fidelity of the methylation pattern and its variation in the genome. (2003) (171)
Lysyl Oxidase Is a Tumor Suppressor Gene Inactivated by Methylation and Loss of Heterozygosity in Human Gastric Cancers (2004) (171)
Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. (2003) (169)
Purification and properties of glycohydrolase from calf thymus splitting ribose-ribose linkages of poly(adenosine diphosphate ribose). (1974) (167)
Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin. (1984) (165)
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. (1984) (163)
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases. (1991) (160)
Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. (1997) (159)
Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. (1998) (159)
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. (1990) (159)
Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. (1995) (157)
Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane. (1997) (156)
Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract. (1984) (155)
Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods. (1987) (155)
Suppression by Flavonoids of Cyclooxygenase‐2 Promoter‐dependent Transcriptional Activity in Colon Cancer Cells: Structure‐Activity Relationship (2000) (152)
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. (2000) (152)
Potent Novel Mutagens Produced by Broiling Fish under Normal Conditions (1980) (151)
Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. (1988) (151)
Identification of 20 genes aberrantly methylated in human breast cancers (2005) (151)
Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development (2004) (150)
Mutagens in coffee and tea. (1979) (146)
Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes. (1972) (146)
Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive. (1974) (143)
Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells (2007) (142)
Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils. (2003) (141)
The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas. (1966) (141)
Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (1995) (141)
Poly(adenosine diphosphate ribose). (1973) (140)
Interactions of norharman and harman with DNA. (1977) (139)
Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers (2003) (137)
Anticarcinogenic effects of (-)-epigallocatechin gallate. (1992) (137)
Frequent loss of heterozygosity on chromosome 14q in neuroblastoma. (1989) (136)
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. (1998) (135)
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats. (1993) (135)
Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma (1990) (135)
Isolation and Structure Determination of Mutagenic Substances in L-Glutamic Acid Pyrolysate (1978) (134)
The response of Parp knockout mice against DNA damaging agents. (2000) (133)
Quantification of the co-mutagenic beta-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods. (1999) (133)
Detection of lymphocytes producing a human retrovirus associated with adult T-cell leukemia by syncytia induction assay. (1983) (133)
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. (1994) (133)
Establishment and characterization of 10 cell lines derived from patients with adult T-cell leukemia. (1983) (132)
Demonstration of Mutagenicity of Aniline and o-Toluidine by Norharman (1977) (130)
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro (1999) (129)
Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide. (1976) (129)
Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-robose) by a calf thymus extract. (1971) (128)
A possible naturally occurring tumor promoter, teleocidin B from Streptomyces. (1979) (128)
Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse Skin (1988) (128)
Structure of a potent mutagen isolated from fried beef. (1981) (128)
Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. (1991) (127)
Immunohistochemical detection of K-sam protein in stomach cancer. (1996) (127)
Preventive Effects of Cladosiphon Fucoidan Against Helicobacter pylori Infection in Mongolian gerbils (2003) (127)
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase. (1987) (126)
Identification of 27 5′ CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers (2004) (124)
Higher Methylation Levels in Gastric Mucosae Significantly Correlate with Higher Risk of Gastric Cancers (2006) (123)
Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors (1981) (123)
Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation (2004) (122)
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice. (2000) (121)
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma. (1992) (121)
Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice (1995) (120)
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. (1998) (120)
Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice (1999) (120)
Chemoprevention by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐induced Mammary Gland Carcinogenesis in Rats (2000) (120)
Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose. (1984) (119)
Test of carcinogenicity of quercetin, a widely distributed mutagen in food. (1980) (118)
Carcinogenic factors in food with relevance to colon cancer development. (1993) (117)
Quantitative nutritional studies with water-soluble, chemically defined diets. VIII. The forced feeding of diets each lacking in one essential amino acid. (1959) (115)
Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. (1984) (115)
Mutagens in coffee and other beverages. (1986) (114)
Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish. (1980) (114)
Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92. (1978) (113)
Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer. (1986) (113)
Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer. (1988) (113)
Past, present, and future of mutagens in cooked foods. (1986) (113)
Genes preferentially expressed in embryo stomach are predominantly expressed in gastric cancer. (1992) (113)
Variable mutations of the RB gene in small-cell lung carcinoma. (1990) (112)
Helicobacter pylori Infection, Serum Pepsinogen Level and Gastric Cancer: A Case‐Control Study in Japan (1995) (112)
Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. (1991) (112)
Polymerization of the adenosine 5'-diphosphate ribose moiety of NAD by rat liver nuclear enzyme. (1967) (111)
Mutagenic factors in cooked foods. (1979) (111)
Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage. (1979) (110)
Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. (2000) (110)
Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1 (2002) (110)
Polymerization of the adenosine 5'-diphosphate-ribose moiety of nicotinamide-adenine dinucleotide by nuclear enzyme. I. Enzymatic reactions. (1967) (108)
SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. (2007) (106)
Promoter methylation profiling of 30 genes in human malignant melanoma (2004) (104)
Poly(ADP‐ribose) and carcinogenesis (2003) (104)
Specific expression of the ret proto-oncogene in human neuroblastoma cell lines. (1990) (104)
Isolation and structure studies of mutagenic principles in amino acid pyrolysates. (1978) (103)
Dose‐dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPARγ ligand (2003) (103)
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line. (1990) (103)
Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, in Min Mice (1997) (103)
Inhibitory effects of antioxidants on formation of heterocyclic amines. (1998) (102)
Carcinogenicity in mice and rats of heterocyclic amines in cooked foods. (1986) (102)
Expressions of the c-Ha-ras and c-myc genes in rat liver tumors. (1984) (102)
Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine (1966) (100)
Differences in effects of norharman with various classes of chemical mutagens and amounts of S-9. (1978) (100)
Sequential morphological changes in N-methyl-N'-nitro-N-nitrosoguanidine carcinogenesis in the glandular stomach of rats. (1970) (99)
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis. (1986) (99)
Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes. (1988) (98)
Presence of human papillomavirus type‐16 and type‐18 DNA sequences and their expression in cervical cancers and cell lines from japanese patients (1986) (96)
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development. (2001) (96)
Comutagenic Action of Norharman and Harman (1977) (95)
Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. (1992) (95)
Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test. (1979) (95)
Genetic changes induced by heterocyclic amines. (1997) (94)
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. (1996) (93)
Detection of novel germ-line p53 mutations in diverse-cancer-prone families identified by selecting patients with childhood adrenocortical carcinoma. (1992) (93)
Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones. (2000) (93)
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. (2001) (93)
Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand (1993) (92)
Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo. (1992) (90)
Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene. (1997) (90)
Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells (2007) (90)
Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). (1997) (90)
Effects of a Soybean Isoflavone Mixture on Carcinogenesis in Prostate and Seminal Vesicles of F344 Rats (1999) (89)
Immunohistochemical Study on Overexpression of c‐erbB‐2 Protein in Human Breast Cancer: Its Correlation with Gene Amplification and Long‐term Survival of Patients (1990) (89)
Multiple genetic alterations in human carcinogenesis. (1992) (89)
Isolation of an Amplified DNA Sequence in Stomach Cancer (1990) (89)
Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems (2009) (88)
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. (1985) (87)
Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product (1991) (87)
Aldolase isozymes in rat tumor cells. (1968) (86)
Aberrant DNA Methylation on Chromosome 16 Is an Early Event in Hepatocarcinogenesis (1996) (86)
Identification of PP1 Catalytic Subunit Isotypes PP1γ1, Pp1δ and Pp1α in Various Rat Tissues (1993) (85)
Germline mutation of BRCA1 in Japanese breast cancer families. (1995) (85)
Amplifications of both c-Ki-ras with a point mutation and c-myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes. (1986) (85)
A novel phosphodiesterase from cultured tobacco cells. (1976) (84)
Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, a precursor of a mutagenic nitroso compound, in soy sauce. (1983) (84)
Hexokinase isozyme patterns of experimental hepatomas of rats. (1969) (84)
Mutagenicity of smoke condensates from cigarettes, cigars and pipe tobacco. (1977) (83)
Structure and chemical synthesis of Me-IQ, a potent mutagen isolated from broiled fish. (1980) (83)
Suppression of Ki‐ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki‐ras mutation but not those without Ki‐ras mutation (1997) (82)
Purification of nitric oxide synthase from bovine brain: immunological characterization and tissue distribution. (1992) (82)
Food and cancer. (2002) (82)
Mutagenicities of nitrofuran derivatives on a bacterial tester strain with an R factor plasmid. (1976) (81)
Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide (1993) (81)
Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes. (1984) (81)
Mutagenicity of methylglyoxal in coffee. (1982) (81)
Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. (1989) (81)
Factors Modulating Mutagenicity in Microbial Tests (1980) (80)
Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds. (1979) (80)
Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers. (2005) (80)
Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity. (1994) (80)
Genetic and epigenetic alterations in carcinogenesis. (2000) (80)
Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid. (1993) (80)
Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic beta-carbolines. (1997) (80)
Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease. (2005) (79)
Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. (1992) (79)
Ultimate forms of mutagenic and carcinogenic heterocyclic amines produced by pyrolysis. (1983) (79)
DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats (1989) (79)
Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. (2004) (78)
Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils. (2002) (77)
Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (1996) (77)
DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. (1996) (77)
A seven-base-pair deletion in an intron of the albumin gene of analbuminemic rats. (1983) (77)
Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines. (1994) (76)
Stimulation of prostaglandin E2 production by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters in macrophages and its inhibition by cycloheximide. (1985) (76)
Effects of docosahexaenoic acid (DHA) on intestinal polyp development in ApcΔ716 knockout mice (1995) (74)
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. (2002) (74)
Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef. (1980) (74)
Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes. (1980) (74)
The branching and linear portions of poly(adenosine diphosphate ribose) have the same alpha(1 leads to 2) ribose-ribose linkage. (1981) (74)
Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids. (1997) (74)
Food Borne Carcinogens: Heterocyclic Amines (2000) (73)
Contents in foods, beverages and tobacco. (2000) (73)
Implication of hydrogen peroxide in the mutagenicity of coffee. (1985) (72)
Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose. (1987) (72)
Appendix III – Mutagens/Carcinogens in Pyrolysates of Amino Acids and Proteins and in Cooked Foods: Heterocyclic Aromatic Amines* (1988) (72)
Modification of Mutagenic Activity (1980) (72)
The role of free oxygen radicals in tumor promotion and carcinogenesis. (1982) (71)
Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. (2011) (71)
Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosylation in its activity. (1999) (71)
Purification and characterization of pepsinogens and a unique pepsin from rat stomach. (1980) (71)
Detection of 2-amino-3-methylimidazo[4,5-f]quinoline in cigarette smoke condensate. (1986) (71)
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods. (1988) (71)
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis. (1982) (70)
c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (1993) (70)
Rat c-raf oncogene activation by a rearrangement that produces a fused protein (1987) (70)
Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats. (1985) (70)
Quantification of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC). (1985) (70)
Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development. (2004) (70)
Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan. (1981) (69)
Parp‐1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane (2003) (69)
Chemical Synthesis of 2-Amino-3-methylimidazo- [4, 5-f]quinoline (IQ), a Potent Mutagen Isolated from Broiled Fish (1980) (69)
Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutation. (1986) (69)
Cholangiocarcinomas in japanese and thai patients: Difference in etiology and incidence of point mutation of the c‐KI‐ras proto‐oncogene (1992) (69)
K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase. (1992) (69)
Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract. (1995) (68)
Isolation and chemical-structural determination of a novel aromatic amine mutagen in water from the Nishitakase River in Kyoto. (1997) (68)
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent (2005) (68)
Mutagenicities of indole and 30 derivatives after nitrite treatment. (1986) (68)
Induction of cancers in the intestine, liver and various other organs of rats by feeding mutagens from glutamic acid pyrolysate. (1984) (68)
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain. (1993) (68)
Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. (1989) (67)
Naturally-occurring antibodies to poly(ADP-ribose) in patients with systemic lupus erythematosus (1977) (66)
Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I. (1986) (66)
Retrospective study on amplification of N-myc and c-myc genes in pediatric solid tumors and its association with prognosis and tumor differentiation. (1988) (66)
Reduced Expression of GNA11 and Silencing of MCT1 in Human Breast Cancers (2003) (65)
Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite. (1984) (65)
Codon 61 Mutations in the c‐Harvey‐ras Gene in Mouse Skin Tumors Induced by 7,12‐Dimethylbenz[a]anthracene Plus Okadaic Acid Class Tumor Promoters (1989) (65)
Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents. (1997) (65)
Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II. (1984) (64)
Formation of 2-amino-3,7,8-trimethylimidazo [4,5-f]quinoxaline, a new mutagen, by heating a mixture of creatinine, glucose and glycine. (1984) (64)
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. (2005) (63)
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. (1986) (63)
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. (1991) (63)
Purification and characterization of small molecular weight myeloperoxidase from human promyelocytic leukemia HL-60 cells. (1981) (63)
Potent mutagenic activity of nitropyrenes on Chinese hamster lung cells with diphtheria toxin resistance as a selective marker. (1982) (63)
Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats (1991) (63)
Absolute configuration oOf lyngbyatoxin A (teleocidin A-1) and teleocidin A-2 (1986) (62)
Studies on poly (adenosine diphosphate-ribose). X. Properties of a partially purified poly (adenosine diphosphate-ribose) polymerase. (1971) (62)
Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells (1988) (62)
Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome. (1984) (62)
DNA Adducts Formed by 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline in Rat Liver: Dose‐Response on Chronic Administration (1990) (61)
Protein phosphatase 1γ2 is associated with nuclei of meiotic cells in rat testis (1993) (60)
A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation. (1982) (60)
Identification of receptor genes in renal cell carcinoma associated with angiogenesis by differential hybridization technique. (1999) (60)
Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid. (1991) (60)
COAMPLIFICATION OF THE hst‐1 AND int‐2 GENES IN HUMAM CANCERS (1988) (59)
Inhibition of hereditary hepatitis and liver tumor development in Long‐Evans cinnamon rats by the copper‐chelating agent trientine dihydrochloride (1996) (59)
ICPEMC publication No. 3. Cigarette smoking--does it carry a genetic risk? (1979) (59)
EIevated serum level of Thioredoxin in patients with Hepatocellular Carcinoma (1998) (59)
Human papillomavirus DNA in squamous cell carcinoma of the upper aerodigestive tract. (1990) (59)
Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine. (1999) (59)
L-arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma. (1991) (59)
Induction of sister-chromatid exchanges by mutagens from amino acid and protein pyrolysates. (1980) (59)
Superoxide dismutase acts as an enhancing factor for quercetin mutagenesis in rat-liver cytosol by preventing its decomposition. (1984) (59)
International Commission for Protection Against Environmental Mutagens and Carcinogens. (1978) (58)
Expression of the c-Ha-ras and c-myc genes in aflatoxin B1-induced hepatocellular carcinomas. (1986) (58)
Enzyme cleaving the 5′‐terminal methylated blocked structure of messenger RNA (1976) (58)
Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following γ-irradiation (1995) (58)
Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells. (1993) (58)
Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs (1997) (58)
Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1991) (58)
Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide. (1989) (58)
A rapid, new method for quantitative analysis of human amylase isozymes. (1974) (57)
Role of flavonoids in suppressing the enhancement of phospholipid metabolism by tumor promoters. (1983) (57)
Hepatic tumors in the guppy (Lebistes reticulatus) induced by aflatoxin B 1 , dimethylintrosamine, and 2-acetylaminofluorene. (1973) (57)
Metabolism of food-derived heterocyclic amines in nonhuman primates. (1997) (56)
Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method. (1997) (56)
Genetic and environmental factors in experimental and human cancer (1980) (56)
Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice. (1996) (56)
Mutagenicity of aclacinomycin A and daunomycin derivatives. (1978) (56)
Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans. (1996) (56)
Isolation and structure elucidation of teleocidin B-1, B-2, B-3, and B-4. (1984) (56)
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells. (1999) (55)
Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. (1998) (55)
Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism. (1983) (55)
Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. (1978) (55)
Comutagenic actions of norharman derivatives with 4-dimethylaminoazobenzene and related compounds (1977) (55)
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (2003) (55)
Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans. (1988) (55)
Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters (1992) (55)
Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs. (1999) (55)
Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene (1986) (55)
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis (2004) (55)
Instability of microsatellites in rat colon tumors induced by heterocyclic amines. (1994) (54)
Genetic alterations of androgen receptor gene in Japanese human prostate cancer. (1997) (54)
Activation of rat c-raf during transfection of hepatocellular carcinoma DNA. (1986) (53)
Polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with Propionibacterium acnes and lipopolysaccharide. (1992) (53)
Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity. (1999) (53)
Identification of a 2-phenylbenzotriazole (PBTA)-type mutagen, PBTA-2, in water from the Nishitakase River in Kyoto. (1998) (53)
Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice (2003) (53)
Expression of the HST1 oncogene in human germ cell tumors. (1988) (52)
Heterocyclic amines in cooked foods: candidates for causation of common cancers. (1994) (52)
Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis (2001) (52)
Protein phosphatases possibly involved in rat spermatogenesis. (1990) (52)
Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. (1996) (52)
Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct. (1988) (52)
Mutagens and carcinogens in food. (1990) (52)
Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. (1989) (51)
Identification of a mutagenic substance in a spice, sumac, as quercetin. (1978) (51)
Presence of Streptococcus DNA Sequence in Surgical Specimens of Gastric Cancer (1995) (51)
Reaction of N-methyl-N'-nitro-N-nitrosoguanidine with protein. (1968) (51)
Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker. (1983) (51)
Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino-3,4-dimethylimidazo[4,5-f]quinoline. (1986) (50)
Amplification of the c-myc oncogene in human stomach cancers. (1984) (50)
Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers. (2002) (50)
Effect of methyl substitution on mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, isolated from broiled sardine. (1981) (50)
Experimental carcinogenesis in small aquarium fishes. (1976) (50)
Mutagens and carcinogens in cooked food. (1986) (49)
Inhibitors of poly(ADP-ribose) polymerase enhance unscheduled DNA synthesis in human peripheral lymphocytes. (1981) (49)
In vivo Interaction of 4-Nitroquinoline-l-oxide and its Derivatives with DNA (1967) (49)
A potent mutagen in broiled fish. Part 1. 2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline (1981) (49)
Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid. (1997) (49)
Studies on poly adenosine diphosphate-ribose. VII. Methods of separation and identification of 2'-(5"-phosphoribosyl)-5'-adenosine monophosphate, ribosyladenosine monophosphate, and phosphoribosyladenosine. (1969) (49)
Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells. (1998) (49)
Striking similarity of the distribution patterns of the poly(ADP-ribose) polymerase and DNA polymerase beta among various mouse organs. (1990) (49)
Estimation of tumor promoting activity and structure-function relationships of aplysiatoxins. (1984) (49)
Poly(ADP-ribose) and cancer research. (1983) (48)
Induction of differentiation of human and murine myeloid leukemia cells in culture by tunicamycin. (1980) (48)
Histologic demonstration of antigens reactive with anti-p21 ras monoclonal antibody (RAP-5) in human stomach cancers. (1986) (48)
Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. (2008) (48)
hst-1 transforming protein: expression in silkworm cells and characterization as a novel heparin-binding growth factor. (1988) (48)
Size and shape of poly(ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy. (1983) (48)
Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro. (1990) (48)
Identification and analysis of the ret proto-oncogene promoter region in neuroblastoma cell lines and medullary thyroid carcinomas from MEN2A patients. (1992) (48)
Single Strand Scissions of DNA caused by a Carcinogen, 4-Hydroxylaminoquinoline I-Oxide (1968) (48)
Isolation and identification of a new 2-phenylbenzotriazole-type mutagen (PBTA-3) in the Nikko river in Aichi, Japan. (2000) (47)
Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline. (1994) (47)
Decreased fidelity in replicating CpG methylation patterns in cancer cells. (2005) (47)
Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine (1975) (47)
Identification of Glycosphingolipid Receptors for Pierisin-1, a Guanine-specific ADP-ribosylating Toxin from the Cabbage Butterfly* (2003) (47)
Differential expression of two homologous and clustered oncogenes, Hst1 and Int-2, during differentiation of F9 cells. (1988) (47)
Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase. (1988) (47)
Presence of Aberrant Transcripts of ret Proto‐oncogene in a Human Papillary Thyroid Carcinoma Cell Line (1989) (47)
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. (2002) (47)
Metabolic aspects of the comutagenic action of norharman. (1981) (46)
Mutagens formed from β-carbolines with aromatic amines (2004) (46)
The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters. (1982) (46)
Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. (2003) (46)
CARCINOGENICITY TEST OF QUERCETIN AND KAEMPFEROL IN RATS BY ORAL ADMINISTRATION (1983) (46)
Carcinogenicity of food mutagens. (1996) (46)
Studies on anti-poly(adenosine diphosphate ribose) antibody. (1974) (46)
Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the 32P‐Postlabeling Method (1994) (46)
Roasting coffee beans produces compounds that induce prophage lambda in E. coli and are mutagenic in E. coli and S. typhimurium. (1983) (46)
Mechanisms of action of okadaic acid class tumor promoters on mouse skin. (1991) (45)
Identification of a reactive metabolite of the mutagen, 2-amino-3-methylimidazolo[4,5-f]quinoline. (1981) (45)
Detection of pX proteins in human T-cell leukemia virus (HTLV)-infected cells by using antibody against peptide deduced from sequences of X-IV DNA of HTLV-I and Xc DNA of HTLV-II proviruses. (1984) (45)
Establishment of a highly sensitive and specific exon-trapping system. (1992) (45)
Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells. (1979) (45)
AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS (1988) (45)
Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium. (1991) (45)
Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. (1997) (45)
Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma. (1990) (44)
Rare frequency of activation of the ki‐ras gene in rat colon tumors induced by heterocyclic amines: Possible alternative mechanisms of human colon carcinogenesis (1993) (44)
Mutagenicity of the naturally occurring carcinogen cycasin and synthetic methylazoxymethanol conjugates in Salmonella typhimurium. (1979) (44)
Involvement of poly (ADP-ribose) metabolism in induction of differentiation of HL-60 promyelocytic leukemia cells. (1982) (44)
Inhibition of tumor promotion by flavonoids. (1986) (44)
Absence of p53 Mutations in Rat Colon Tumors Induced by 2‐Amino‐6‐methyldipyrido[1,2‐a:3′, 2′‐d]imidazole, 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline, or 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1994) (44)
Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene. (1990) (44)
Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (1995) (44)
Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA. (1981) (44)
The presence of aldolase C in rat hepatoma. (1970) (44)
New classes of environmental tumor promoters: indole alkaloids and polyacetates. (1983) (44)
Presence in Pieris rapae of Cytotoxic Activity against Human Carcinoma Cells (1996) (44)
APC gene mutations in human prostate cancer. (1996) (44)
A mutagen precursor in Chinese cabbage, indole-3-acetonitrile, which becomes mutagenic on nitrite treatment. (1985) (44)
Reduced expression of the insulin‐induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers (2002) (43)
Identification of 2-[2-(acetylamino)-4-amino-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-4) as a potent mutagen in river water in Kyoto and Aichi prefectures, Japan. (2001) (43)
Infrequent mutation of ha‐ras and p53 in rat mammary carcinomas induced by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1994) (43)
A rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing. (1996) (43)
Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials. (1985) (43)
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals. (1996) (43)
Frequent mutations of the rat β‐catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1‐hydroxyanthraquinone (1999) (43)
Induction of poly(ADP-ribose) polymerase gene expression in lectin-stimulated human T lymphocytes is dependent on protein synthesis. (1988) (43)
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody. (1998) (43)
Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food‐borne Carcinogen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (2002) (43)
Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. (1984) (43)
Loss of heterozygosity on chromosomes 1p and 11p in sporadic pheochromocytoma. (1989) (43)
Separation of human α-amylase isozymes by electro-focusing and their immunological properties (1975) (43)
LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1. (2002) (43)
Marked increase in the urinary level of N-nitrosothioproline after ingestion of cod with vegetables. (1988) (42)
Conservation of E6 and E7 regions of human papillomavirus types 16 and 18 present in cervical cancers. (1987) (42)
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor. (2000) (42)
Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells. (1988) (42)
Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells. (1994) (42)
The effect of norharman on the metabolism of benzo[alpha]pyrene by rat-liver microsomes in vitro in relation to its enhancement of the mutagenicity of benzo[alpha]pyrene. (1978) (42)
Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. (1987) (42)
Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet. (2002) (42)
In vitro Transformation of Hamster Embryo Cells with Tryptophan Pyrolysis Products (1977) (42)
Expression of ret Proto‐oncogene in Human Neuroblastomas (1990) (42)
Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. (1997) (42)
Infrequent loss of chromosomal heterozygosity in human stomach cancer. (1988) (42)
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates. (1990) (42)
History, present and future, of heterocyclic amines, cooked food mutagens. (1995) (42)
Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines. (1999) (41)
Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats. (1991) (41)
Differential proliferative response of gastric mucosa during carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI rats, resistant Buffalo rats, and their hybrid F1 cross. (1988) (41)
Phenanthroindolizidine alkaloids as cytotoxic substances in a Danaid butterfly, Ideopsis similis, against human cancer cells. (2001) (41)
Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC. (1996) (41)
Analysis of estrogenic activity of foodstuffs and cigarette smoke condensates using a yeast estrogen screening method. (2003) (40)
Etiology-specific gene expression profiles in rat mammary carcinomas. (2002) (40)
Biological actions of nitroarenes in short-term tests on Salmonella, cultured mammalian cells and cultured human tracheal tissues: possible basis for regulatory control. (1983) (40)
Aggregation of human lymphoblastoid cells by tumor-promoting phorbol esters and dihydroteleocidin B. (1980) (40)
Poly(adenosine diphosphate ribose) synthesis during the cell cycle of transformed hamster lung cells. (1973) (40)
Flat reversion by okadaic acid of raf and ret-II transformants. (1989) (40)
Activation of the EBV‐cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin a, aplysiatoxin and debromoaplysiatoxin (1983) (39)
Expression of proto-ret mRNA in embryonic and adult rat tissues. (1988) (39)
Studies on poly(adenosine diphosphate-ribose). XI. Purification of poly(adenosine diphosphate-ribose) on a hydroxylapatite column. (1971) (39)
Activated oncogenes in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline. (1985) (39)
Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin. (1990) (39)
High susceptibility to azoxymethane‐induced colorectal carcinogenesis in obese KK‐Ay mice (2011) (39)
第3類の新規しゅよう促進剤,ポリアセタート(デブロモアプリシアトキシンおよびアプリシアトキシン)のしゅよう促進効果に関与する生物効果の分化 (1982) (39)
LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo. (2004) (39)
Mutagenicities of Bangkok and Tokyo river waters. (1994) (39)
Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. (1995) (39)
Nicotinamide mononucleotide-dependent incorporation of ATP into acidinsoluble material in rat liver nuclei preparation (1967) (39)
A blue-green alga from Okinawa contains aplysiatoxins, the third class of tumor promoters. (1985) (39)
Presence of branched portion in poly(adenosine diphosphate ribose) in vivo. (1982) (38)
Enhancement of Carcinogenesis and Fatty Infiltration in the Pancreas in N-Nitrosobis(2-Oxopropyl)Amine-Treated Hamsters by High-Fat Diet (2011) (38)
Degradation of mutagens from pyrolysates of tryptophan, glutamic acid and globulin by myeloperoxidase. (1979) (38)
Cloning of the rat agouti gene and identification of the rat nonagouti mutation (2001) (38)
Appearance of direct-acting mutagenicity of various foodstuffs produced in Japan and Southeast Asia on nitrite treatment. (1985) (38)
The effect of limited administration of N-methyl-N'-nitro-N-nitrosoguanidine on the induction of stomach cancer in rats. (1970) (38)
A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity. (1995) (38)
Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. (1994) (38)
Induction of aberrant crypt foci in C57BL/6N mice by 2-amino-9H-pyrido[2,3-b]indole (A alphaC) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). (1997) (37)
Quantitative nutritional studies with water-soluble, chemically defined diets. VII. Nitrogen balance in normal and tumor-bearing rats following forced feeding. (1959) (37)
How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention. (2000) (37)
LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences. (2001) (37)
Short chain intermediate in DNA replication of Ehrlich ascites tumor cells. (1970) (37)
Mutagens Produced by Heating Foods (1983) (37)
Activated c-raf gene in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline. (1985) (37)
Sensitivity of repair-deficient mutants and similar mutants to 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives. (1972) (36)
Multiple forms of phosphofructokinase in rat tissues and rat tumors. (1972) (36)
SYNTHESES OF POTENT MUTAGENS IN TRYPTOPHAN PYROLYSATES (1977) (36)
Purification of Pierisin, an Inducer of Apoptosis in Human Gastric Carcinoma Cells, from Cabbage Butterfly, Pieris rapae (1998) (36)
Binding of ADP-ribose polymer with histone. (1969) (36)
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A (2004) (36)
Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae. (2000) (36)
The effect of dose and enzyme inducers on the metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats. (1991) (36)
p53 Gene Mutations in Human Prostate Cancers in Japan: Different Mutation Spectra between Japan and Western Countries (1994) (36)
Characteristics of major mutagenicity of instant coffee. (1985) (35)
Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells. (1981) (35)
Synthesis of 2-phenylbenzotriazole-type mutagens, PBTA-5 and PBTA-6, and their detection in river water from Japan. (2001) (35)
Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid. (1987) (35)
Induction of epstein‐barr virus by a new tumor promoter, teleocidin, compared to induction by TPA (1981) (35)
Two homologous oncogenes, HST1 and INT2, are closely located in human genome. (1988) (35)
Role of Fat and Calcium in Cancer Causation by Food Mutagens, Heterocyclic Amines (1994) (35)
Presence of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole in broiled beef. (1980) (35)
Inactivation of mutagens from pyrolysates of tryptophan and glutamic acid by nitrite in acidic solution. (1980) (35)
Chemical, enzymatic, and cytochrome assays of microsomal fraction of hepatomas with different growth rates. (1966) (35)
Potent tumor promoters other than phorbol ester and their significance. (1982) (35)
Mode of action of rat liver phosphodiesterase on a polymer of phosphoribosyl adenosine monophosphate and related compounds. (1968) (35)
Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice. (1994) (35)
Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite. (1989) (34)
Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx. (1993) (34)
Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1996) (34)
Cloned hst gene from normal human leukocyte DNA transforms NIH3T3 cells. (1988) (34)
Adenovirus-mediated transfer of the HST-1 (FGF4) gene induces increased levels of platelet count in vivo. (1994) (34)
Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). (1997) (34)
Enzymatic removal of the 5′‐terminal methylated blocked structure of tobacco mosaic virus RNA and its effects on infectivity and reconstitution with coat protein (1976) (34)
Mutagens in Japanese pickle identified as flavonoids. (1979) (34)
Sulfite suppresses the mutagenic property of coffee. (1982) (33)
Fractionation of a mutagenic principle from broiled fish by high-pressure liquid chromatography. (1979) (33)
BRCA2 germline mutations in Japanese breast cancer families (1997) (33)
Preferential expression of the third immunoglobulin-like domain of K-sam product provides keratinocyte growth factor-dependent growth in carcinoma cell lines. (1994) (33)
Perinatal changes in amylase and serum corticosterone levels in rats. (1977) (33)
Let's be scientific about the problem of mutagens in cooked food. (1978) (33)
Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin. (1983) (33)
Degradation of poly(adenosine diphosphate ribose) by homogenates of various normal tissues and tumors of rats. (1975) (33)
Presence of albumin mRNA precursors in nuclei of analbuminemic rat liver lacking cytoplasmic albumin mRNA. (1982) (33)
Isolation and structure determination of a mutagenic substance in L-lysine pyrolysate. (1978) (33)
Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells (2001) (33)
Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo. (1994) (33)
Genetic alterations in rat colon tumors induced by heterocyclic amines (1996) (33)
A 13C NMR study of poly(adenosine diphosphate ribose) and its monomers: evidence of alpha-(1'' leads to 2') ribofuranosy1 ribofuranoside risidue. (1977) (33)
Experimental Stomach Carcinogenesis (1978) (33)
New tumor promoters from marine natural products (1990) (32)
Mutagenicities of 4-hydroxy-1,4-benzoxazinones naturally occurring in maize plants and of related compounds (1979) (32)
Quantification of two aromatic amine mutagens, PBTA-1 and PBTA-2, in the yodo river system. (1999) (32)
PP1 gamma 2, a testis-specific protein-serine/threonine-phosphatase type 1 catalytic subunit, is associated with a protein having high sequence homology with the 78-kDa glucose-regulated protein, a member of the 70-kDa heat shock protein family. (1994) (32)
Carcinogenicity in rats of a mutagenic compound, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, from tryptophan pyrolysate. (1985) (32)
Skin tumors in mice painted with N-methyl-N'-nitro-N-nitrosoguanidine and N-ethyl-N'-nitro-N-nitrosoguanidine. (1971) (32)
Significance of new environmental tumor promoters (1989) (32)
Inhibition of Intestinal Polyp Formation by Pitavastatin, a HMG-CoA Reductase Inhibitor (2011) (32)
Amplification and over-expression of the c-myc gene in Morris hepatomas. (1984) (32)
DNA adduct levels of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in tissues of cynomolgus monkeys after single or multiple dosing. (1994) (32)
Helicobacter pylori May Be Transmitted through Gastrofiberscope Even after Manual Hyamine Washing (1993) (32)
A Major CYP2D6 Autoepitope in Autoimmune Hepatitis Type 2 and Chronic Hepatitis C is a Three-dimensional Structure Homologous to Other Cytochrome P450 Autoantigens (2002) (32)
Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats. (2005) (32)
A respiration-deficient mutant of Saccharomyces cerevisiae which accumulates porphyrins and lacks cytochromes. (1966) (32)
Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism. (1982) (32)
Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis. (2006) (31)
Effects of 4-week treatment with gastric carcinogens and enhancing agents on proliferation of gastric mucosa cells in rats. (1989) (31)
Detection of phosphorylated retTPC oncogene product in cytoplasm. (1992) (31)
Formation of DNA adducts by the co-mutagen norharman with aromatic amines. (1996) (31)
Germ-line p53 mutation is uncommon in patients with triple primary cancers. (1993) (31)
Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils. (1987) (31)
Heterocyclic amines produced in cooked food: unavoidable xenobiotics. (1990) (31)
Detection of a common mutation of the catalase gene in Japanese acatalasemic patients (1992) (31)
Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors. (2005) (31)
Identification and quantification of 2-amino-3,4,8-trimethylimidazo- [4,5-f]quinoxaline (4,8-DiMeIQx) in beef extract. (1985) (31)
Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450. (1979) (31)
Immunofluorescent staining of poly(ADP-ribose) in situ in HeLa cell chromosomes in the M phase. (1981) (31)
Molecular cloning of the human hepatitis C virus genome from Japanese patients with nonA , non-B hepatitis ( RNA virus / gene structure / nucleotide sequence ) (31)
RNA bound to nascent DNA in Ehrlich ascites tumor cells. (1972) (31)
Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii (2006) (31)
Turnover of serum proteins in rats with analbuminemia. (1979) (31)
Induction of differentiation of mouse myeloid leukemia cells by poly(ADP-ribose). (1978) (30)
Hst-1 (FGF-4) antisense oligonucleotides block murine limb development (1995) (30)
Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. (1994) (30)
Chemical synthesis of a novel aromatic amine mutagen isolated from water of the Nishitakase River in Kyoto and a possible route of its formation. (1998) (30)
Molecular cloning of rat phosphoprotein phosphatase 2Aβ cDNA and increased expressions of phosphatase 2Aα and 2Aβ in rat liver tumors (1988) (30)
Molecular cloning and characterization of human ret-II oncogene. (1988) (30)
International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication No. 5: An evaluation of the genetic toxicity of dichlorvos. (1980) (30)
Dose‐dependent Induction of Mammary Carcinomas in Female Sprague‐Dawley Rats with 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1996) (30)
Expression of PP2A B regulatory subunit β isotype in rat testis (1993) (30)
Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (1992) (30)
Activation of human c-raf-1 by replacing the N-terminal region with different sequences. (1987) (30)
Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats. (2004) (30)
Mutagenicity of instant coffee on cultured Chinese hamster lung cells. (1984) (29)
Norharman and Harman in Human Urine (1995) (29)
Mechanism of potent mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine on intracellular phage lambda. (1978) (29)
Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma. (2007) (29)
Mutagenicity of alcoholic beverages. (1981) (29)
Minisatellite instability in severe combined immunodeficiency mouse cells. (1997) (29)
Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. (2005) (29)
Heterocyclic amines formed in the diet : Carcinogenicity and its modulation by dietary factors (1998) (29)
Poly(ADP-ribose) Glycohydrolase deficiency sensitizes mouse ES cells to DNA damaging agents. (2009) (29)
Experimental chemical carcinogenesis in the stomach and colon. (1998) (29)
Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter. (1983) (29)
Protein serine/threonine phosphatases as binding proteins for okadaic acid. (1995) (29)
Whole‐genome analyses of loss of heterozygosity and methylation analysis of four tumor‐suppressor genes in N‐methyl‐N′‐nitro‐N‐nitrosoguanidine‐induced rat stomach carcinomas (2005) (28)
Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C), in male F344 rats. (1994) (28)
Suppression of azoxymethane‐induced colon cancer development in rats by a prostaglandin E receptor EP1‐selective antagonist (2005) (28)
Mutagenicities of gamma-carboline derivatives related to potent mutagens found in tryptophan pyrolysates. (1980) (28)
Methylglyoxal in beverages and foods: its mutagenicity and carcinogenicity. (1986) (28)
The adaptive formation of ubiquinone 30 (coenzyme Q6) in yeast. (1960) (28)
Interaction of N-methyl-N'-nitro-N-nitrosoguanidine with ascites hepatoma cells in vitro. (1969) (28)
Cloning of the 5’Upstream Region of the Rat p16 Gene and Its Role in Silencing (2002) (28)
Detection of ki-ras mutation in nonneoplastic mucosa of Japanese patients with colorectal cancers. (1994) (28)
SPECIES DIFFERENCES IN MICROSOMAL ACTIVATION OF MUTAGENS AND CARCINOGENS, WITH SPECIAL REFERENCE TO NEW POTENT MUTAGENS FROM PYROLYSATES OF AMINO ACIDS AND PROTEINS (1980) (28)
Inhibition of experimental blood-borne lung metastasis by protease inhibitors. (1980) (28)
Electrophoretic and immunological properties of liver α-amylase of well-fed and fasted rats (1975) (28)
Studies of nuclear ADP-ribosylation. (1980) (28)
Immortalization of peripheral blood lymphocytes of cats by human T‐cell leukemia virus (1984) (28)
Mutagenic heterocyclic amines in cooked food. (1981) (28)
Identification of new gene products coded from X regions of human T-cell leukemia viruses. (1985) (28)
Demonstration of high molecular weight poly (adenosine diphosphate ribose). (1978) (28)
Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis. (2006) (28)
Effects of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine on intestinal polyp development in ApcΔ716 knockout mice (1996) (27)
Effects of docosahexaenoic acid (DHA) on intestinal polyp development in Apc delta 716 knockout mice. (1995) (27)
Marked Enhancement by Fish Meal of Helicobacter pylori‐induced Gastritis in Mongolian Gerbils (2000) (27)
Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin B. (1981) (27)
Overexpression of low‐density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice (2009) (27)
Co-mutagenic effect of norharman with N-nitrosamine derivatives. (1981) (27)
Mutagenicities of phenacetin and its metabolites. (1978) (27)
Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene. (1995) (27)
Binding of 14 C-labeled 4-nitroquinoline 1-oxide to DNA in vivo. (1970) (26)
Enzymatic properties of pierisin-1 and its N-terminal domain, a guanine-specific ADP-ribosyltransferase from the cabbage butterfly. (2004) (26)
NO CORRELATION BETWEEN L‐myc RESTRICTION FRAGMENT LENGTH POLYMORPHISM AND MALIGNANCY OF HUMAN COLORECTAL CANCERS (1988) (26)
Morphological differentiation of cultured mouse glioblastoma cells induced by dibutyryl cyclic adenosine monophosphate. (1975) (26)
Mutagens in cooked food. (1982) (26)
Effects of tumor promoters on the frequency of metallothionein I gene amplification in cells exposed to cadmium. (1983) (26)
Malignant transformation in vitro by tryptophan pyrolysis products. (1978) (26)
Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2 (2005) (26)
Mutagenicity of quercetin in Chinese hamster lung cells in culture. (1986) (26)
Marked reduction of Helicobacter pylori-induced gastritis by urease inhibitors, acetohydroxamic acid and flurofamide, in Mongolian gerbils. (2001) (26)
The presence of single nucleotide instability in human breast cancer cell lines. (2001) (26)
Identification of a transforming activity suppressing sequence in the c-raf oncogene. (1988) (26)
Protein phosphatase 1 gamma 2 is associated with nuclei of meiotic cells in rat testis. (1993) (26)
Periodic analysis of urethane‐induced pulmonary tumors in living A/J mice by respiration‐gated X‐ray microcomputed tomography (2008) (26)
Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins. (2006) (26)
Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. (1992) (26)
Single nucleotide instability without microsatellite instability in rat mammary carcinomas. (2001) (26)
Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. (1985) (25)
Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2‐Amino‐3,4‐dimethylimidazo[4,5‐f]quinoline, in Different Strains of Mice (1999) (25)
Studies on mammary carcinogenesis induced by a heterocyclic amine, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine, in mice and rats (2002) (25)
Identification of transforming genes as hst in DNA samples from two human hepatocellular carcinomas. (1987) (25)
Atrophy of Salivary Glands and Pancreas of Rats fed on Diet with Amino-methyl-a-carboline (1985) (25)
Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. (2006) (25)
Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture. (1986) (25)
Effects of deoxyribonucleic acid and histone on the number and length of chains of poly(adenosine diphosphate-ribose). (1973) (25)
Depression of DNA polymerase activity in chromatin by incubation with NAD. (1972) (25)
Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. (1987) (25)
Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (1992) (25)
The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite. (1988) (25)
Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats (1992) (25)
The metabolism of 4-nitroquinoline 1-oxide. I. Conversion of 4-nitroquinoline 1-oxide to 4-aminoquinoline 1-oxide by rat liver enzymes. (1965) (25)
Insertional mutation of the Attractin gene in the black tremor hamster (2001) (25)
Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin. (1984) (25)
In vivo amplification and rearrangement of the c-Ha-ras-1 sequence in a human bladder carcinoma. (1983) (24)
Intramolecular quadruplex formation of the G-rich strand of the mouse hypervariable minisatellite Pc-1. (1999) (24)
No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. (1998) (24)
Poly(ADP-ribose): Historical perspective (1994) (24)
Detection of 2‐Amino‐1‐methyl‐6‐(4‐hydroxyphenyl)imidazo[4,5‐b]pyridine in Broiled Beef (1992) (24)
Inhibition of teleocidin-caused epidermal ornithine decarboxylase induction by phospholipase A2-, cyclooxygenase- and lipoxygenase-inhibitors. (1985) (24)
Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility. (1999) (24)
Suppression of azoxymethane‐induced colon cancer development in rats by a cyclooxygenase‐1 selective inhibitor, mofezolac (2006) (24)
Induction of Tumors in the Forestomach and Liver of Mice by Feeding 2-Amino-3, 4- dimethylimidazo [4, 5-f] quinoline (1985) (24)
Absence of albumin mRNA in the liver of analbuminemic rats. (1980) (24)
Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly. (2002) (24)
SYNTHESIS OF 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-f]QUINOXALINE (Me-IQx), A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (24)
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. (2009) (24)
Okadaic acid, a protein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridine. (1993) (24)
K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors. (1992) (24)
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. (1992) (23)
In vitro and in vivo formation of aminophenylnorharman from norharman and aniline. (2002) (23)
Presence of 2-aminodipyrido[1,2-a: 3',2'-d]imidazole in broiled cuttlefish. (1980) (23)
Hydrolysis of the polymer formed from NAD with rat liver phosphodiesterase yielding nucleoside 5'monophosphate. (1967) (23)
Myristylation of gag protein in human T-cell leukemia virus type-I and type-II. (1985) (23)
Studies on poly adenosine diphosphate-ribose. 8. A method for purification of poly adenosine diphosphate-ribose. (1970) (23)
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. (2001) (23)
Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid. (1984) (23)
Kinetics of nitrosation of thioproline, the precursor of a major nitroso compound in human urine, and its role as a nitrite scavenger. (1984) (23)
Immunoaffinity fractionation of the poly(ADP-ribosyl)ated domains of chromatin. (1983) (23)
Silencing of the thrombomodulin gene in human malignant melanoma (2005) (23)
Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers. (2001) (23)
Increased sperm abnormalities due to dietary restriction (1982) (23)
Identification of 29 Rat Genetic Markers by Arbitrarily Primed Polymerase Chain Reaction (1996) (23)
Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene. (1985) (22)
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (2004) (22)
Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentaene-12 and -14. (1989) (22)
Frequent Detection of Hepatitis C Virus US Strain in Japanese Hemophiliacs (1990) (22)
Sequential histologic changes during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI and resistant BUF rats. (1986) (22)
Evaluation of a selective prostaglandin E receptor EP1 antagonist for potential properties in colon carcinogenesis. (2001) (22)
Studies on poly (adenosine diphosphate ribose). V. Mechanism of hydrolysis of poly (adenosine diphosphate ribose) by snake venom phosphodiesterase. (1970) (22)
Bacterial mutagenicity of natural materials, pyrolysis products and additives in foodstuffs and their association with genotoxic effects in mammals. (1983) (22)
Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promoters on the adipocyte differentiation of 3T3-L1 cells. (1983) (22)
Determination of human exposure to the dietary carcinogen 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) from hemoglobin adduct: the relationship to DNA adducts. (1992) (22)
Coproporphyrinogenase in a Respiration-deficient Mutant of Yeast Lacking All Cytochromes and Accumulating Coproporphyrin (1968) (22)
Presence of N-nitroso-L-thioproline and N-nitroso-L-methylthioprolines in human urine as major N-nitroso compounds. (1983) (22)
Transfection of K-rasAsp12 cDNA markedly elevates IL-1β- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells (2003) (22)
Structural determination of a new mutagenic heterocyclic amine, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (7,9-DiMeIgQx), present in beef extract. (1994) (21)
The effect of aerobiosis and diphenylamine on the content of ubiquinone in Rhodospirillum rubrum. Biochim Biophys. (1962) (21)
Natural occurence of a biopolymer, poly (adenosine diphosphate ribose). (1977) (21)
Mutagenic activity of norharman and harman in Chinese hamster lung cells in assays with diphtheria toxin resistance as a marker. (1983) (21)
Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. (2002) (21)
Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation. (1995) (21)
Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. (2005) (21)
Heterocyclic amine-DNA adducts analyzed by 32P-postlabeling method. (1988) (21)
Reduction of enzyme activity of tyrosine hydroxylase and aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by carcinogenic heterocyclic amines. (1988) (21)
Mutagenicity of smoke condensates from joss sticks. (1980) (21)
Activation of mutagenic and carcinogenic heterocyclic amines by S-9 from the liver of a rhesus monkey. (1987) (21)
Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. (2008) (21)
Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells. (1992) (21)
Tumorigenicity and gene amplification potentials of cyclin D1-overexpressing NIH3T3 cells. (1995) (21)
Enhancing effect of phorbol esters on induction of differentiation of mouse myeloid leukemia cells by human urinary protein and lipopolysaccharide. (1979) (21)
Metabolic activation of 3-amino-5H-pyrido[4,3-b]indole, a highly mutagenic principle in tryptophan pyrolysate, by rat liver enzymes. (1979) (21)
Genomic clone of hst with transforming activity from a patient with acute leukemia. (1987) (21)
The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines. (1991) (21)
Induction of gastric carcinomas in nonhuman primates by N-ethyl-N'-nitro-N-nitrosoguanidine. (1986) (21)
Enhancement of antitumor activity of bleomycin by benzamide in vitro and in vivo. (1983) (21)
Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae. (2004) (20)
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin. (1984) (20)
Mutagenic compounds in soy sauce, Chinese cabbage, coffee and herbal teas. (1986) (20)
Improvement of hyperlipidemia by indomethacin in Min mice (2007) (20)
Comutagenic effect of norharman with aminopyridine derivatives. (1982) (20)
Marked formation of thiazolidine-4-carboxylic acid, an effective nitrite trapping agent in vivo, on boiling of dried shiitake mushroom (Lentinus edodes) (1990) (20)
Marked increases of two kinds of two-exon-skipped albumin mRNAs with aging and their further increase by treatment with 3'-methyl-4-dimethylaminoazobenzene in Nagase analbuminemic rats. (1991) (20)
Inhibitors of poly(adenosine diphosphate ribose) polymerase potentiate the antitumor activity of bleomycin against Ehrlich ascites carcinoma. (1982) (20)
New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B. (1990) (20)
Rat liver microsome-mediated binding to DNA of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a potent mutagen isolated from tryptophan pyrolysate. (1978) (20)
Cysteine-rich regions conserved in amino-terminal halves of raf gene family products and protein kinase C. (1986) (20)
Non-covalent interaction between poly(ADP-ribose) and cellular proteins: an application of a poly(ADP-ribose)-western blotting method to detect poly(ADP-ribose) binding on protein-blotted filter. (1994) (20)
[A case of incomplete Kearns-Sayre syndrome with a stroke like episode]. (1997) (20)
Involvement of the ATR- and ATM-Dependent Checkpoint Responses in Cell Cycle Arrest Evoked by Pierisin-1 (2006) (20)
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP‐induced large bowel carcinogenesis (2007) (20)
Experimental Gastric Cancers (1993) (20)
Inhibition by norharman of metabolism of benzo[a]pyrene by the microsomal mixed function oxidase of rat liver. (1980) (20)
Nitrite converts 2-amino-α-carboline, an indirect mutagen, into 2-hydroxy-α-carboline, a non-mutagen and 2-hydroxy-3-nitroso-α-carboline, a direct mutagen (1981) (20)
Identification of 4,8-DiMeIQx, a new mutagen (1985) (20)
Morusin, isolated from root bark of Moms alba L., inhibits tumour promotion of teleocidin (1989) (20)
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. (2006) (20)
An overview of cancer prevention. (1996) (20)
Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors. (1992) (20)
Myeloperoxidases in cultured human promyelocytic leukemia cell line HL-60. (1981) (19)
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas. (2000) (19)
Suppression of Gl Arrest and Enhancement of G2 Arrest by Inhibitors of Poly(ADP‐ribose) Polymerase: Possible Involvement of Poly(ADP‐ribosyl)ation in Cell Cycle Arrest Following γ‐Irradiation (1994) (19)
A potent mutagen isolated from a pyrolysate of L-ornithine. (1981) (19)
Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. (2002) (19)
HST1 and INT2 gene coamplification in a squamous cell carcinoma of the gallbladder. (1989) (19)
Resiniferonol-related Diterpene Esters from Daphne odora Thunb. and their Ornithine Decarboxylase-inducing Activity in Mouse Skin (1982) (19)
Identification of PP1 catalytic subunit isotypes PP1 gamma 1, PP1 delta and PP1 alpha in various rat tissues. (1993) (19)
Carcinogenicity of heterocyclic amines for the pancreatic duct epithelium in hamsters. (1999) (19)
Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae (2008) (19)
Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters. (1986) (19)
Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. (2004) (19)
Comparative studies on electrophoretic mobility and immunogenicity of pancreatic and parotid amylases of rat. (1975) (19)
Presence of nitrosable mutagen precursors in cooked meat and fish. (1988) (19)
Ki‐ras Activation in Pancreatic Carcinomas of Syrian Hamsters Induced by N‐Nitrosobis(2‐hydroxypropyl)amine (1991) (19)
Isolation and identification of a new mutagen, 2-amino-4-hydroxy-methyl-3,8-dimethylimidazo[4,5-f]quinoxaline (4-CH2OH-8-MeIQx), from beef extract. (1994) (19)
Synthesis and mutagenicity of 10-azabenzo[a]pyrene-4,5-oxide and other pentacyclic aza-arene oxides. (1978) (18)
Antimutagenic Effect of Elastatinal, a Protease Inhibitor from Actinomycetes (1977) (18)
Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. (1985) (18)
A factor in human saliva that induces differentiation of mouse myeloid leukemia cells. (1978) (18)
HST-1/FGF-4 stimulates proliferation of megakaryocyte progenitors synergistically and promotes megakaryocyte maturation. (1996) (18)
4-Methoxyindole derivatives as nitrosable precursors of mutagens in Chinese cabbage. (1986) (18)
Activation of c-Ki-ras gene in human pancreatic cancer. (1985) (18)
Comparative studies on antibody and antibody production to poly(ADP-ribose) in mice. (1978) (18)
Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food‐borne Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (1995) (18)
Relationship between histone H1 poly(adenosine diphosphate ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate ribose) antibody. (1983) (18)
Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaate. (1990) (18)
A novel monoclonal antibody permitting recognition of NKT cells in various mouse strains. (1998) (18)
Increment of the cyclin D1 mRNA level in TPA-treated three human myeloid leukemia cell lines: HEL, CMK and HL-60 cells. (1993) (18)
Novel germline mutation of the PTEN gene in a Japanese family with Cowden disease (2003) (18)
Cancer prevention: past, present, future. (1998) (17)
Multiple genetic alterations in small-cell lung carcinoma. (1989) (17)
Dietary modulation of the carcinogenicity of the heterocyclic amines. (1995) (17)
Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi. (2009) (17)
Presence of albumin-positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogens. (1986) (17)
Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae. (2004) (17)
Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription. (2002) (17)
Aldolase C in Brain Tumour (1969) (17)
DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity. (1998) (17)
Purification and DNA-binding properties of human papillomavirus type 16 E6 protein expressed in Escherichia coli. (1989) (17)
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. (2006) (17)
Cloning and functional expression of poly(ADP-ribose) polymerase cDNA from Sarcophaga peregrina. (1994) (17)
Expression of human poly(ADP-ribose) polymerase with DNA-dependent enzymatic activity in Escherichia coli. (1989) (17)
Genetic alterations in HCA-induced tumors. (1995) (17)
Inactivation of potent pyrolysate mutagens by chlorinated tap water. (1983) (17)
Oxidation of sulfhydryl compounds in vitro by 4-hydroxyaminoquinoline-1-oxide, a carcinogenic metabolite of 4-nitroquinoline-1-oxide. (1967) (17)
N-acetyl derivative as the major active metabolite of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole in rat bile. (1986) (17)
Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis. (2001) (17)
Comparative studies on antibodies to poly(ADP-ribose) in rabbits and patients with systemic lupus erythematosus. (1981) (17)
Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly. (2003) (17)
Intestinal metaplasia of the stomach as a precancerous stage. (1982) (17)
Teleocidin: new naturally occurring tumor promoter. (1982) (17)
Frequent Development of Murine T‐Cell Lymphomas with TcRα/β+, CD4‐/8 Phenotype after Implantation of Human Inflammatory Breast Cancer Cells in BALB/c Nude Mice (1995) (17)
Occurrence of multiforms of α-amylase, new isozymes or autodigested forms? (1975) (17)
CHEMICAL AND TOXICOLOGICAL STUDIES ON BRACKEN FERN, PTERIDIUM AQUILINUM VAR. LATIUSCULUM. IV. SURVEYS ON BRACKEN CONSTITUENTS BY MUTAGEN TEST (1978) (16)
Detection of endogenous DNA adducts, O6‐carboxymethyl‐2′‐deoxyguanosine and 3‐ethanesulfonic acid‐2′‐deoxycytidine, in the rat stomach after duodenal reflux (2008) (16)
Aldolase C in experimental brain tumor. (1970) (16)
Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice. (1988) (16)
Experimental gastric cancer. (1991) (16)
Chapter 3 – The Use of Mutagenicity to Evaluate Carcinogenic Hazards in Our Daily Lives (1982) (16)
Mutagens formed from beta-carbolines with aromatic amines. (2004) (16)
Effect of methyl substitution on mutagenicity of 2-amino-dipyrido [1,2- a :3′,2′- d ] imidazole, Glu-P-2 (1980) (16)
Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats. (2001) (16)
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates. (1995) (16)
Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. (2004) (16)
Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. (2003) (16)
Poly-ADP-ribosylation in health and disease (2005) (16)
7 – Mutagenesis: Microbial Systems (1978) (16)
Long‐term prognosis and prognostic factors of liver cirrhosis in the 1980s (1994) (16)
Tumor Promoting Activities of New Synthetic Analogues of Teleocidin (1985) (16)
Spontaneous mutations in the Helicobacter pylori rpsL gene. (2003) (15)
Mutagens and Carcinogens Formed by Cooking Meat and Fish: Heterocyclic Amines (1990) (15)
Mouse 3T3-L1 cell variants unable to respond to mitogenic stimulation of dihydroteleocidin B: genetic evidence for the synergism of tumor promoters with growth factors. (1986) (15)
Linkage Analysis of BRCA1 in Japanese Breast Cancer Families (1994) (15)
Purification of mouse pepsinogens by pepstatin‐affinity chromatography (1978) (15)
N-2 acetylation of 2'-deoxyguanosine by coffee mutagens, methylglyoxal and hydrogen peroxide. (1990) (15)
Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins (1983) (15)
Detection of Aminophenylnorharman, a Possible Endogenous Mutagenic and Carcinogenic Compound, in Human Urine Samples (2007) (15)
Enhancement of Epstein-Barr virus-induced transformation of human lymphocytes by teleocidin. (1981) (15)
cDNA Cloning of BRγ, A Novel Brain-specific Isoform of the B Regulatory Subimit of Type-2A Protein Phosphatase (1995) (15)
Metabolic aspects of pyrolysis mutagens in food. (1986) (15)
No involvement of APC gene mutations in ulcerative colitis–associated rat colon carcinogenesis induced by 1‐hydroxyanthraquinone and methylazoxymethanol acetate (1997) (15)
Purification and properties of an acid protease from human ascitic fluid. (1978) (15)
Solubilization of enzyme forming ADPR polymer from NAD. (1967) (15)
Induction of specific antibodies to poly(ADP–ribose) in rabbits by double-stranded RNA, poly(A)·poly(U) (1978) (15)
Occurrence of mutations in the epidermal growth factor receptor gene in X‐ray‐induced rat lung tumors (2008) (15)
Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline. (2002) (15)
Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells treated with tumor-promoting indole alkaloids or polyacetates. (1983) (15)
Recently identified nitrite-reactive compounds in food: occurrence and biological properties of the nitrosated products. (1987) (15)
Study of the promoting effect of sodium chloride on gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in inbred Wistar rats. (1984) (15)
Perinatal changes of alpha-fetoprotein concentration in the serum and its synthesis in the liver of analbuminemic rats. (1982) (15)
Binding studies of [3H]lyngbyatoxin A and [3H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction. (1986) (15)
Uptake of heterocyclic amines, Trp-P-1 and Trp-P-2, into clonal rat pheochromocytoma PC12h cells by dopamine uptake system (1989) (14)
3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomes (1990) (14)
Modulation of phorbol ester receptors in mouse skin by application of quercetin. (1986) (14)
Studies on polymer of adenosine diphosphate ribose. VI. Radioautographic demonstration of incorporation of NAD into nuclear macromolecule. (1969) (14)
Pendolmycin, a New Tumor Promoter of the Teleocidin A Class on Skin of CD‐1 Mice (1991) (14)
p53 Gene Mutation in Hepatocellular Carcinoma Induced by 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates (1994) (14)
Amplified DNA sequences in cancers. (1985) (14)
Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation. (1990) (14)
High frequency and low specificity of ras gene mutations in rat Zymbal's gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. (1993) (14)
Preparation of potent concentrates of toxohormone free from nucleic acid. (1955) (14)
Effect of poly(ADP-ribose)polymerase inhibitors on the frequency of sister-chromatid exchanges in Bloom syndrome cells. (1983) (14)
Structure of poly(adenosine diphosphate ribose). (1982) (14)
Amino-methyl-.ALPHA.-carboline-induced DNA modification in rat salivary glands and pancreas detected by 32P-postlabeling method. (1986) (14)
UBIQUINONE IN RESPIRATION-DEFICIENT MUTANTS OF SACCHAROMYCES CEREVISIAE. (1964) (14)
Number of Cytoplasmic Factors in Yeast Cells (1966) (14)
Y chromosome abnormality in human stomach and lung cancer. (1987) (14)
1-Nitrosoindole-3-acetonitrile, a mutagen produced by nitrite treatment of indole-3-acetonitrile. (1985) (14)
Inhibition of intercellular communication in Chinese hamster V79 cells by teleocidin. (1982) (14)
Mouse NK1.1+ cytotoxic T cells can be generated by IL-2 exposure from lymphocytes which express an intermediate level of T cell receptor. (1998) (14)
Nakahara memorial lecture. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. (1983) (14)
The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf. (1987) (13)
A new modification of the 32P-post-labeling method to recover IQ-DNA adducts as mononucleotides. (1999) (13)
Serum Antibody against Unfused Recombinant E7 Protein of Human Papillomavirus Type 16 in Cervical Cancer Patients (1995) (13)
The mechanism of liver catalase depression by 3-amino-1, 2, 4-triazole. (1956) (13)
Partial purification of adenosine 3',5'-cyclic monophosphate phosphodiesterases from rat pancreas in the presence of excess protease inhibitors. (1976) (13)
Erratum: Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody (Human Gener Therapy (20 January, 1998) 9, 2 (235-248)) (1998) (13)
Development of exocrine cells of the pancreas and parotid gland in rats. Relation between morphological and biochemical changes. (1978) (13)
Detection and Cloning of a Protein Recognized by Anti‐human Prostate‐specific Antigen (PSA) Antibody in the Rat Ventral Prostate (2001) (13)
Non-enzymatic glutathione conjugation of 2-nitroso-6-methyldipyrido [1,2-a: 3',2'-d] imidazole (NO-Glu-P-1) in vitro: N-hydroxy-sulfonamide, a new binding form of arylnitroso compounds and thiols. (1988) (13)
Prophage λ induction test (inductest) of anti-tumor antibiotics (1981) (13)
Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype. (1994) (13)
Carcinogenicity in animals and specific organs. (2000) (13)
Heterocyclic amines: new mutagens and carcinogens in cooked foods. (1991) (13)
Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline. (2004) (13)
A 29 kDa GTP-binding protein expressed in mouse brain, lung, kidney, spleen and transformed NIH3T3 cells. (1987) (13)
In vitro reaction of hydroxyamino derivatives of MeIQx, Glu-P-1 and Trp-P-1 with DNA: 32P-postlabelling analysis of DNA adducts formed in vivo by the parent amines and in vitro by their hydroxyamino derivatives. (1988) (13)
A new fluorescent microassay method for pepsin using succinyl-albumin. (1978) (13)
Properties of nascent DNA of Ehrlich ascites tumor cells obtained by nitrocellulose column chromatography. (1972) (13)
Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse (2001) (13)
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride. (1992) (13)
Detection of Frequent p 53 Gene Mutations in Primary Gastric Cancer by Cell Sorting and Polymerase Chain Reaction Single-Strand Conformation Polymorphism Analysis (2006) (13)
Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat (2003) (13)
DNA adducts formed by the comutagens harman and norharman in various tissues of mice. (1988) (13)
32P-postlabeling analysis of DNA adducts in rat stomach with 1-nitrosoindole-3-acetonitrile, a direct-acting mutagenic indole compound formed by nitrosation. (1988) (13)
Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines (1998) (13)
Neoplastic transformation and chromosomal aberrations induced by N-methyl-N'-nitro-N-nitrosoguanidine in hamster lung cells in tissue culture. (1972) (13)
Inhibition of chemically induced sister chromatid exchanges by elastatinal. (1979) (12)
Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. (1981) (12)
CHEMICAL CARCINOGENESIS IN ANALBUMINEMIC RATS (1988) (12)
Mutagenicity of 5-nitroacenaphthene in salmonella. (1975) (12)
Translesional DNA Synthesis through a C8-Guanyl Adduct of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro (2009) (12)
Biochemical studies on carcinogenesis in the glandular stomach of rats with N-methyl-N'-nitro-N-nitrosoguanidine. (1973) (12)
Highly efficient method for obtaining a subtracted genomic DNA library by the modified in-gel competitive reassociation method. (1994) (12)
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines. (2010) (12)
NMR analyses of conformation of ribosyl adenosine 5',5''-bis(phosphate) in aqueous solution. (1978) (12)
Ordering of human chromosome 3p markers by radiation hybrid mapping. (1992) (12)
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2. (1987) (12)
Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis? (2002) (12)
A case report on the development of biliary tract cancer eleven years after the injection of thorotrast. (1957) (12)
Production of Phytoene, an Oxidative Stress Protective Carotenoid, in Mammalian Cells by Introduction of Phytoene Synthase Gene crtB Isolated from a Bacterium Erwinia uredovora (1995) (12)
Identification and characterization of three isotypes of protein phosphatase inhibitor-2 and their expression profiles during testis maturation in rats. (1996) (12)
Genetic determinant and environmental carcinogens. (1998) (12)
Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine, PhIP. (1999) (12)
Combined analysis of microsatellite instability and K-ras mutation increases detection incidence of normal samples from colorectal cancer patients. (1997) (12)
Transforming activity of human melanoma DNA. (1983) (12)
Formation and characterization of antibody against 2'-(5"-phosphoribosyl)-5' AMP, the monomer form of poly(adenosine diphosphate ribose). (1978) (12)
Myeloperoxidases of human myeloid leukemia cells HL-60 grown in culture and in nude mice. (1983) (12)
Role of protein phosphatases in malignant transformation. (1989) (12)
Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea (2006) (12)
Presence of 2-aminodipyrido[1,2-a:3',2'-d]imidazole in casein pyrolysate. (1979) (12)
Expression of PP2A B regulatory subunit beta isotype in rat testis. (1993) (11)
Induction of putative new cytochrome P450 isozyme in rat liver by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (1991) (11)
The Absence of Mth1 Inactivation and DNA Polymerase k Overexpression in Rat Mammary Carcinomas with Frequent A:T to C:G Transversions (2002) (11)
Identification and characterization of fibroblast growth factor-related transforming gene hst-1. (1991) (11)
Quantitative nutritional studies with water-soluble, chemically defined diets. IX. Further studies on d-glucosaminecontaining diets. (1959) (11)
Etiology and prognosis of liver cirrhosis in elderly patients. (1995) (11)
Effect of poly(ADP-ribose) formation on DNA synthesis and DNA fragmentation in nuclei of rat liver and rat ascites hepatoma AH-130 cells. (1973) (11)
Construction of a phylogenetic tree for inbred strains of rat by arbitrarily primed polymerase chain reaction (AP-PCR) (1995) (11)
Detection of mutagenicity of diphenyl ether herbicides in Salmonella typhimurium YG1026 and YG1021. (1995) (11)
An improved method for detecting mutagens (1978) (11)
Detection and isolation of minisatellite Pc-1 binding proteins. (2001) (11)
Tumor promoter-dependent mouse leukemia cell line. (1983) (11)
Quantitative Nutritional and In Vivo Metabolic Studies with Water-Soluble, Chemically Defined Diets (1960) (11)
Induction of histidine decarboxylase activity in mouse skin after application of indole alkaloids, a new class of tumor promoter. (1982) (11)
Genetic analysis of a respiration-deficient mutant of Saccharomyces cerevisiae lacking all cytochromes and accumulating coproporphyrin. (1967) (11)
Aldolase C in cultured mouse glioblastoma cells. (1972) (11)
Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors. (1991) (11)
In vitro transformation of hamster embryo cells by betel tobacco extracts (1978) (11)
Mechanism of appearance of mutagenicity of N-nitrosodiphenylamine with norharman. (1982) (11)
Advances in Brief Role of the Prostaglandin E Receptor Subtype EP 1 in Colon Carcinogenesis 1 (1999) (11)
Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-ribose) Polymerase (1992) (11)
Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection (2004) (11)
Inhibition of deoxyribonuclease in an extract of rat liver nuclei by poly(ADP-ribose). (1974) (11)
Enhancement of the mutagenicities of N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea by glucose. (1980) (11)
Diversity in the chemical nature and mechanism of response to tumor promoters. (1989) (11)
Porphyrin metabolism in tumor-bearing animals; free porphyrin in liver, harderian gland and urine and the effect thereon on toxohormone. (1956) (11)
Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues (2002) (10)
A TaqI RFLP in the human ret proto-oncogene. (1990) (10)
Chronic Administration of the Mutagenic Heterocyclic Amine 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine Induces Cardiac Damage with Characteristic Mitochondrial Changes in Fischer Rats (1996) (10)
A new pathway of tumor promotion by the okadaic acid class compounds. (1990) (10)
[Experimental gastric cancer (author's transl)]. (1976) (10)
Detection of thioredoxin in gastric cancer: association with histological type. (2000) (10)
Presence of p53 Mutations in 3Y1‐B Clone 1‐6: A Rat Cell Line Widely Used as a Normal Immortalized Fibroblast (1994) (10)
VARIETY OF PHENOTYPICAL EXPRESSION OF INTESTINAL MARKER ENZYMES AND MUCIN IN HUMAN STOMACH INTESTINAL METAPLASIA (1980) (10)
Sampling method as a key factor in identifying K-ras oncogene mutations in preneoplastic colorectal lesions. (1995) (10)
Activation of N-ras gene in a rat hepatocellular carcinoma induced by dibutylnitrosamine and butylated hydroxytoluene. (1987) (10)
Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611). (1992) (10)
(−)Maackiain acetate specifically inhibits different forms of aryl hydrocarbon hydroxylase in rat and man (1981) (10)
Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence. (1993) (10)
Demonstration of Cytotoxicity against Wasps by Pierisin-1: A Possible Defense Factor in the Cabbage White Butterfly (2013) (10)
New environmental carcinogens in daily life. (1988) (10)
Quantification of mutagenic/carcinogenic heterocyclic amines in cooked foods (1985) (10)
Food as source of complex mixtures of mutagens and carcinogens. (1990) (10)
Detection of heterocyclic amines in human urine (1991) (10)
Production of shorter mRNA for protein phosphatase 2A beta by alternative poly(A) addition. (1990) (10)
Studies on ubiquinone (coenzyme Q) in neoplastic tissues. (1962) (10)
Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys (1999) (10)
Oxidation of the 2-hydroxyamino derivative of 2-amino-6-methyl-dipyrido[1,2-a: 3',2'-d] imidazole (Glu-P-1) to its 2-nitroso form, an ultimate form reacting with hemoglobin thiol groups. (1988) (10)
Presence of human papillomavirus type-6-related sequences in inverted nasal papillomas (2004) (9)
Elevation of serum albumin concentration in analbuminemic rats by administration of 3'-methyl-4-dimethylaminoazobenzene. (1982) (9)
Bioassay of environmental carcinogens with the guppy, Lebistes reticulatas (1975) (9)
Calcification and angioproliferation in epicardium of mouse induced by mutagenic/carcinogenic heterocyclic amine. (1987) (9)
Selective inhibition by acriflavine of cytochrome a and b synthesis in yeast undergoing aerobic adaptation. (1965) (9)
Phosphodiesterase from cultured tobacco cells. Physical and chemical properties. (1977) (9)
Analysis by in Vitro Mutagenesis of PP2Aα Okadaic Acid Responsive Sequences (1995) (9)
Improvement of the Spi‐ assay for mutations in gpt delta mice by including magnesium ions during plaque formation (2003) (9)
Induction of diphtheria toxin-resistant cells by mutagen-carcinogens. (1983) (9)
Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates. (2005) (9)
Poly(adenosine diphosphate ribose) glycohydrolase in Physarum polycephalum. (1976) (9)
Modification of cytochrome c with N-methyl-N'-nitro-N-nitrosoguanidine. (1971) (9)
Enhancement by m-Aminobenzamide of Methylazoxymethanol Acetate-Induced Hepatoma of the Small Fish “Medaka” (Oryzias latipes) (1985) (9)
Testicular toxicity in F344 rats by aminophenylnorharman, formed from norharman and aniline. (2001) (9)
Active H-ras and N-ras in rat fibrosarcomas induced by 1,6-dinitropyrene. (1987) (9)
CATALASE DEPRESSING TISSUE FACTORS (1955) (9)
The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. (1996) (9)
Studies on poly(adenosine diphosphate ribose). IX. Direction of hydrolysis of poly(adenosine diphosphate ribose) by rat liver phosphodiesterase. (1970) (9)
[46] Structure of poly(ADP-ribose) (1984) (9)
Utilization of protoporphyrin for the synthesis of cytochrome C in yeast deficient of heme biosynthesis. (1970) (9)
Increased serum soluble IL-2 receptor levels following interferon therapy in patients with chronic hepatitis C. (1999) (9)
Effect of TPA on the mutagenicity of caffeine in the soybean mutation test (1983) (9)
Effects of heterocyclic amines in food on dopamine metabolism in nigro-striatal dopaminergic neurons. (1988) (9)
Studies on in vivo degradation of rat hepatic catalase with or without modification by 3-amino-1,2,4-triazole. (1974) (9)
Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays (2003) (9)
14 – The possible involvement of mutagenic and carcinogenic heterocyclic amines in human cancer (2006) (9)
Nitrosatable precursors of mutagens in vegetables and soy sauce. (1985) (9)
Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers. (1999) (9)
Myeloperoxidase-catalyzed binding of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a tryptophan pyrolysis product, to protein. (1980) (8)
Presence of different types of procollagen messenger RNAs in human hepatoma cell lines. (1987) (8)
Polymerization of ADPR moiety of NAD by nuclear enzyme preparation. (1968) (8)
Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X‐ray micro‐computed tomography (CT) (2010) (8)
METABOLISM OF 4-NITROQUINOLINE 1-OXIDE (1966) (8)
Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis. (2002) (8)
Mono(ADP-ribosyl)ation of DNA by apoptosis-inducing protein, pierisin. (2002) (8)
Induction of glandular stomach cancers in Helicobacter pylori‐infected Mongolian gerbils by 1‐nitrosoindole‐3‐acetonitrile (2012) (8)
32P-Postlabeling analysis of a DNA adduct, an N2-acetyl derivative of guanine, formed in vitro by methylglyoxal and hydrogen peroxide in combination. (1996) (8)
Hemoproteins in microsomes in liver of tumor-bearing rats. (1965) (8)
Role of Poly-ADP-Ribosylation in Cancer Development (2006) (8)
Local antigen‐driven oligoclonal expansion of B cells in the liver portal areas of patients with primary biliary cirrhosis (2003) (8)
Existence of an optimal dose of dihydroteleocidin B for skin tumor promotion. (1982) (8)
Metabolism of 4-nitroquinoline 1-oxide. IV. Quantitative determination of in vivo conversion of 4-nitroquinoline 1-oxide in subcutaneous tissue of rat. (1968) (8)
The role of fat and calcium in the production of foci of aberrant crypts in the colon of rats fed 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine. (1994) (8)
Mutagenic properties of 2-amino-N6-hydroxyadenine in Salmonella and in Chinese hamster lung cells in culture. (1991) (8)
Poly(ADP-ribose): structure, quantification, and biological significance. (1983) (8)
Induction of respiration-deficient mutant of Saccharomyces cerevisiae by pinacyanol (1969) (8)
STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (8)
Strong Inhibition of 2‐Amino‐6‐methyldipyrido[l,2‐a:3′,2′‐d]imidazole‐induced Mutagenesis and Hepatocarcinogenesis by 1‐O‐Hexyl‐2,3,5‐trimethylhydroquinone (1993) (8)
Transforming activity of human c-Ha-ras-1 proto-oncogene generated by the binding of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole and 4-nitroquinoline N-oxide: direct evidence of cellular transformation by chemically modified DNA. (1987) (8)
Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter (2004) (8)
Restriction fragment length polymorphism of the rat albumin gene in Sprague-Dawley rats and its application in genetic study of analbuminemia. (1982) (8)
The human poly(ADP-ribose) glycohydrolase maps to chromosome 10q11.23-21.1 by fluorescence in situ hybridization. (1998) (8)
Isolation of 48 genetic markers appropriate for high throughput genotyping of inbred rat strains by B1 repetitive sequence-representational difference analysis (1998) (8)
Activated N-ras oncogene in a transformant derived from a rat small intestinal adenocarcinoma induced by 2-aminodipyrido[1,2-a:3',2'-d]imidazole. (1987) (8)
Poly(ADP-ribose) polymerase-1 gene in human tumor cell lines: Its expression and structural alteration (2004) (8)
Gallium-67 scintigraphy in the diagnosis and management of chronic sarcoid myopathy (2003) (8)
Changes in protease during differentiation of mouse myeloid leukemia cells. (1979) (7)
Anti-cancer Substance in Pieris brassicae (1997) (7)
Identification of Rat cDNA for the Catalytic Subunit of Glycogen Bound form PP-1 (1990) (7)
Serendipitous discoveries from sudden inspirations and the joy of being a scientist. (2002) (7)
Mutagenicity of soy sauce treated with a physiologically feasible concentration of nitrite. (1986) (7)
Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acids and tyramine as precursors of mutagens in soya sauce after nitrite treatment. (1984) (7)
Chapter 15 – Phosphodiesterases and Poly(ADP-ribose) Glycohydrolase (1982) (7)
COLORECTAL CANCER Downregulation of prostaglandin E receptor subtype EP 3 during colon cancer development (2004) (7)
Mutagenicity of azo-compounds — Improved method for detecting their mutagenicities by the Salmonella mutation test (1978) (7)
Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias. (1983) (7)
INTERACTION BETWEEN QUERCETIN AND Ca2+-CALMODULIN COMPLEX (1984) (7)
Structure of poly(ADP-ribose). (1984) (7)
Rare Activation of the Human c‐Ha‐ras Transgene of Mice in Hemangioendothelial Sarcomas and Liver Tumors Induced by Glu‐P‐1 (1996) (7)
Molecular biology of the hst-1 gene. (1990) (7)
Mutagenicity of optically pure (--)trans-7,8-dihydroxy-dihydrobenzo[a]pyrene. (1978) (7)
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats. (1996) (7)
Phenotype of a Temperature-Sensitive, Respiration-Deficient (cyt) Mutant of Yeast (1972) (7)
Studies on the mechanism of catalase depression by toxohormone, with the aid of allylisopropylacetamide, allylisopropylacetylcarbamide, and 3-amino-1,2,4-triazole. (1962) (7)
Mutagen—carcinogens in amino acid and protein pyrolysates and in cooked food (1981) (7)
Crystallization of rat liver aldolase. (1968) (6)
Inhibition of chemically induced sister chromatid exchanges by protease inhibitors from Streptomyces. (1980) (6)
Glycolytic inhibition of carcinostatic quinone and quinoline derivatives. (1957) (6)
Portal‐systemic shunting in a patient with normal portal vein pressures and histological evidence of idiopathic portal hypertension (1996) (6)
Interaction of N-methyl-N'-nitro-N-nitrosoguanidine with DNA and histone in rat tissues in vivo. (1973) (6)
Chapter 3 – Structure and Properties of Poly(ADP-ribose) (1982) (6)
Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance. (2003) (6)
Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus. (2007) (6)
Binding of orally given 2-amino-6-methyldipyrido (1,2-a:3',2'-d) imidazole, a carcinogen, to rat hemoglobin. (1986) (6)
Hereditary hepatitis in LEC rats: accumulation of abnormally high ploid nuclei. (1989) (6)
Carcinogenicity of dinitropyrenes in rats and hamsters. (1986) (6)
Effects of heterocyclic amines with mammary gland carcinogenic potential on estrogenic response of uterus in ovariectomized rats. (2001) (6)
[45] Overview of poly(ADP-ribosyl)ation (1984) (6)
Early Gastric Cancer Induced by N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in a Cynomolgus Monkey Six Years after Initial Diagnosis of the Lesion (1990) (6)
Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly. (2005) (6)
Isolation and structural determination of a mutagenic substance in creatine pyrolysate. (1991) (6)
A high phosphorylation state and increased activity of the TRE motif in the NIH3T3 cell transformant induced by retTPC. (1991) (6)
Separation of human alpha-amylase isozymes by electro-focusing and their immunological properties. (1975) (6)
Food and cancer prevention. (1997) (6)
Effect of Tumor Promoters in Relation to the Cell Membrane (1983) (6)
Effects of various hormones and adrenalectomy on the levels of amylase in rat pancreas and parotid gland (1977) (6)
Biological significance of the hst-1 gene. (1989) (6)
Chromosomal localization of putative tumor-suppressor genes in several human cancers. (1991) (6)
Effective prevention of thrombocytopenia using adenovirus-mediated transfer of HST-11FGF-4 gene: in vivo and in vitro studies. (1997) (5)
Proceedings: Anti-poly(ADP-ribose) antibody and its specificity. (1975) (5)
Structural analysis of a mature hst-1 protein with transforming growth factor activity. (1991) (5)
Properties of Poly(Adenosine Diphosphate Ribose) Polymerase, Poly(Adenosine Diphosphate Ribose) Glycohydrolase and Poly(Adenosine Diphosphate Ribose) (1973) (5)
Marked increase in urinary excretion of nitrate and N-nitrosothioproline in the osteogenic disordered syndrome rats, lacking ascorbic acid biosynthesis, by administration of lipopolysaccharide and thioproline. (1995) (5)
Studies on Poly Adenosine Diphosphate-Ribose (2003) (5)
Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae (2011) (5)
On the bacteriostatic action of some basic protein fractions obtained from neoplastic tissues. (1957) (5)
Construction of a high-throughput rat genetic mapping system with 466 arbitrarily primed-representational difference analysis markers (2000) (5)
Metabolism of 4-nitroquinoline 1-oxide. II. In vivo conversion of subcutaneously injected 4-nitroquinoline 1-oxide to 4-aminoquinoline 1-oxide and 4-hydroxyquinoline 1-oxide in rats. (1966) (5)
SUPEROXIDE RESPONSE INDUCED BY INDOLE ALKALOID TUMOR PROMOTERS * (1983) (5)
Two‐dimensional Electrophoretic Analysis of Hepatitis‐associated Polypeptides in Liver of LEC Rats Developing Spontaneous Hepatitis (1990) (5)
Abrogation of G1 arrest after DNA damage is associated with constitutive overexpression of Mdm2, Cdk4, and Irf1 mRNAs in the BALB/c 3T3 A31 variant 1-1 clone. (1997) (5)
Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly. (2007) (5)
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen , 2-amino-1-methyl-6-phenylimidazo [ 4 , 5b ] pyridine (2004) (5)
[129] Polymerization of the adenosine 5′-diphosphate-ribose moiety of NAD (1971) (5)
A new type of N-nitrosamino acid, N-nitroso-L-thioproline and N-nitroso-L-methylthioprolines, found in human urine as major N-nitroso compounds. (1984) (5)
Isolation and Identification of 5-Hydroxymaltol, a Mutagenic Substance in Glucose Pyrolysate (1983) (5)
Molecular aspects of growth control. An extended report on the first joint meeting of the AACR and the Japanese Cancer Association. (1989) (5)
Nucleotide sequence analysis of human T-cell leukemia virus type II. (1984) (5)
Report of the Thirteenth International Symposium of the Foundation for Promotion of Cancer Research: cancer screening-past, present and future. (2000) (5)
Structure of the pX protein deduced from the nucleotide sequence of a cDNA clone of pX mRNA in cells infected with human T-cell leukemia virus type I. (1985) (5)
Effect of cigarette smoking and dietary factors on the amount of N-nitrosothiazolidine 4-carboxylic acid and N-nitroso-2-methyl-thiazolidine 4-carboxylic acid in human urine. (1987) (5)
Complex factors pertinent to human hazard risk. (2000) (5)
Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17. (2005) (5)
The reduction of ubiquinone (coenzyme Q) in chromatophores of Rhodospirillum rubrum by succinate. (1962) (5)
Historical background of studies on environmental chemical carcinogenesis in Japan and recent progress in toxicology of carcinogens. (1986) (5)
Quantification of in vivo levels of poly(ADP-ribose): tritium labeling method and radioimmunoassay. (1984) (5)
Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient. (1987) (5)
Cancer prevention: underlying principles and practical proposals. (1990) (5)
Recent Studies on the ret Proto-oncogene (1989) (5)
Analysis of mutant K-ras in multiple sites of normal appearing mucosa of colorectal cancer patients. (1996) (5)
[The purification of toxohormone]. (1956) (5)
Multiple steps in carcinogenesis, multiple carcinogenic factors, and multiple primary tumors: can we develop an appropriate response for cancer prevention? (1998) (4)
In the beginning when the Japanese Environmental Mutagen Society was established (2016) (4)
Frequent and Multiple Mutations at Minisatellite Loci in Sporadic Human Colorectal and Gastric Cancers—Possible Mechanistic Differences from Microsatellite Instability in Cancer Cells (2002) (4)
Detection of mutant diphtheria toxin-resistant Chinese hamster lung cells in situ by autoradiography. (1986) (4)
Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin. (1984) (4)
Appearance of albumin-producing cells in the liver of analbuminemic rats on aging and administration of mutagens. (1985) (4)
Effect of growth in vivo and in vitro on phenotype of hexokinase isozymes in hepatoma cells. (1972) (4)
Integration of v-rasH does not necessarily transform an immortalized murine cell line. (1984) (4)
Persistence of pierisin-1 activities in the adult cabbage white butterfly, Pieris rapae, during storage after killing (2007) (4)
Reduced Brca1 protein expression in 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine–induced rat mammary carcinomas (2002) (4)
Distribution of radioactive iron injected into tumor-bearing animals. (1957) (4)
Monoclonal antibodies against poly(ADP-ribose) recognize different structures of poly(ADP-ribose). (1983) (4)
Erythrocyte porphyrin in blood of tumor bearing animals. (1956) (4)
Amounts of heterocyclic amines in basic fraction of cigarette smoke condensates (1986) (4)
Successful treatment of pure red cell aplasia and autoimmune cytopenia with cyclosporine and prednisolone in a patient with SjÖgren’s syndrome (2003) (4)
Effects of Chronic Administration of Low Doses of 2‐Ammo‐3,8‐dimethylimidazo‐[4,5‐f]qumoxaline on Glutathione S‐Transferase Placental Form‐positive Foci Development in the Livers of Rats Fed a Choline‐deficient Diet (1993) (4)
Crystallization and properties of aldolase from a transplantable rat sarcoma. (1969) (4)
Anti-cancer action of 6-carboxy-4-nitroquinoline 1-oxide. (1957) (4)
Food-derived Mutagens and Carcinogens1 (2006) (4)
Activation of chemicals to proximal carcinogens. (1980) (4)
Inhibitory Effect of 2‐0‐Octadecylascorbic Acid in Agglutination Assay with Concanavalin A; Short‐term Examination of Rat Urinary Bladder Carcinogenesis (1991) (4)
What is new about ADP-ribosylation? (2006) (4)
Genetic polymorphisms and susceptibility to cancer development. (1995) (4)
Impairment in S-phase entry of splenocytes of Parp-1 knockout mice (2004) (4)
Difference in sensitivity of Salmonella typhimurium strains to alkylating agents (1978) (4)
Multistage carcinogenesis: the Twenty-Second International Symposium of the Princess Takamatsu Cancer Research Fund. (1992) (4)
Strong diuretic effect of pepstatin, an acid protease inhibitor. (1978) (4)
Lack of altered frequency of sister-chromatid exchanges in poly(ADP-ribose) glycohydrolase-deficient mouse ES cells treated with methylmethanesulfonate (2003) (4)
Mutagens formed by nitrite treatment of Chinese cabbage (1986) (3)
Purification of toxohormone. (1957) (3)
Characterization of the PP2Aa gene mutation in okadaic acid-resistant variants of CHO-K1 cells (3)
Partial purification and properties of cathepsin G-like proteinase of mouse myeloid leukemia M1 cells. (1990) (3)
Past victories, uncertainty, and reflections on the present and progress in the future (1998) (3)
ADDITIVE ACTION OF FIVE HETEROCYCLIC AMINES IN TERMS OF INDUCTION OF GTS-P POSITIVE SINGLE CELLS AND FOCI IN RAT LIVER-CORRELATION WITH DNA ADDUCT FORMATION (1994) (3)
[Helicobacter pylori infection in gastric cancer]. (1993) (3)
Promoter-induced cellular responses closely correlated with the enhancement of cell transformation. (1983) (3)
Overview of poly(ADP-ribosyl)ation. (1984) (3)
Induction of multinucleated cells and apoptosis in the PC‐3 prostate cancer cell line by low concentrations of polyethylene glycol 1000 (2008) (3)
Rapid isolation of cell-type-specific protein tyrosine kinases by degenerate polymerase chain reaction combined with differential hybridization technique. (1995) (3)
cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase. (1995) (3)
Digestive Tract Tumors (1986) (3)
Correlation between the carcinogenicities of nitrofuran derivatives and their destructive actions on sebaceous glands of mouse skin. (1975) (3)
Generation of polymorphic markers tightly linked to the thymus enlargement loci by phenotype-directed representational difference analysis (1998) (3)
in mouse two-stage skin carcinogenesis (2005) (3)
A novel transforming gene, hst, from human stomach cancers and a non-cancerous portion of stomach mucosa. (1986) (3)
Cytotoxic phenanthroindolizidine alkaloids in Tylophora tanakae against human gastric carcinoma cells (2000) (3)
A Hen Enzyme ADP-ribosylates Normal Human and Mutated c-Ha-ras Oncogene Products Synthesized in Escherichia coli (1986) (3)
Effects of albumin and other proteins during assay of amylase activity. (1977) (3)
MUTAGENIC OR DNA-MODIFYING ACTIVITIES OF N -ALKYL- N '-NITRO- N -NITROSOGUANIDINE (1975) (3)
Transfection of Kras Asp 12 cDNA markedly elevates IL-1 band lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells (2003) (3)
Definition of a novel CYP2D6 epitope in autoimmune hepatitis type 2 and in chronic hepatitis C (1998) (3)
Molecular Cloning of cDNA for Human Placental Poly(ADP-Ribose) Polymerase and Decreased Expression of its Gene during Retinoic Acid-Induced Granulocytic Differentiation of HL-60 Cells (1989) (3)
On mutagens in foods, especially on compounds from pyrolysis of protein (1978) (3)
Non-protein and protein sulfhydryl groups in neoplastic tissues. (1957) (3)
Modification by dietary fat of mammary gland carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in female SD x F344 F1 hybrid rats (1997) (3)
Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (1996) (3)
cDNA cloning of the rat APC gene and assignment to Chromosome 18 (1995) (3)
Linkage mapping of the rat Tp53 gene on Chromosome 10 (1996) (3)
Immunoreactivities of alpha-amylase of humans and rats. (1977) (3)
Report of the meeting on fundamental and clinical research in multiple primary cancer. (1990) (3)
Symposium on fundamental and clinical research in liver cancer. (1990) (3)
Catalase depressing tissue factors: toxohormone and kochsaft factor. (1955) (3)
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene (2004) (2)
Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives (2004) (2)
[Biosynthesis of ADP ribose polymer from NAD with nuclear enzymes]. (1967) (2)
PrecancerousChanges in the Stomach (1976) (2)
Further studies on the reduction of triphenyltetrazolium chloride by the succinic dehydrogenase complex. (1957) (2)
Analysis of an RNA adduct formed from aminophenylnorharman. (2009) (2)
Mutagenicities of new non-alternant isomers of benzo[a]pyrene. (1980) (2)
Presence of fast moving type IV hexokinase isozyme in Morris hepatoma. (1973) (2)
Indole alkaloids : Dihydroteleocidin B , teleocidin , and lyngbyatoxin (2)
Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. (2009) (2)
Proceedings: Enzymes degrading poly(ADP-ribose) from Physarum polycephalum and Nicotiana tabacum. (1975) (2)
Recollection: Dr. Frederick J. de Serres and the environmental mutagenesis and carcinogenesis panel established under the auspices of the US-Japan Cooperative Medical Science Program. (1999) (2)
Detection of harman and norharman in human urine (1991) (2)
Relation between carcinogenicity and metabolic reduction of 4-nitroquinoline 1-oxide derivatives (1970) (2)
Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase (2000) (2)
Characterization of DNA adducts formed by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in vitro and in vivo (1995) (2)
Regulation of DNA polymerase ß by poly(ADP-ribose) polymerase (1992) (2)
Poly(ADP-ribose) Preparation Using Anion-Exchange Column Chromatography (2009) (2)
Extensive Purification of Nuclear Poly(ADP-ribose) Glycohydrolase (1992) (2)
Review of submammalian systems for detecting mutagens and carcinogens (1978) (2)
Phenantroindolizidine Alkaloids as Cytotoxic Substances in a Danaid Butterfly, Ideopsis similis, Against Human Cancer Cells. (2001) (2)
EFFECT OF IRON ADMINISTRATION ON THE FREE PROTOPORPHYRIN LEVELS IN ERYTHROCYTE AND LIVER OF TUMOR-BEARING RATS (1959) (2)
Identification of Three New Mutagenic Heterocyclic Amines and Human Exposure to Known Heterocyclic Amines (2005) (2)
A seven base pair deletion in an intron blocks albumin mRNA processing. (1982) (2)
Mutagen Formation after Heating of Mixtures of Guanidino Compounds, Amino Acids and Glucose (1994) (2)
Pseudotype viruses bearing envelope antigens of Japanese isolates of human T-cell leukemia viruses type I. (1984) (2)
[Pierisin, an apoptosis-inducing protein from cabbage butterfly]. (2001) (2)
Induction of delta-aminolevulinic acid synthetase in cultured friend leukemia cells by dimethyl sulfoxide and human placental extract. (1974) (2)
Activation of rat and human c-raf(-1) by rearrangement. (1986) (2)
DIRECT-ACTING MUTAGENS FORMED FROM AMINOIMIDAZOQUINOLINES BY PHOTO-IRRADIATION (1988) (2)
Defective secretion of albumin encoded by exon-skipped mRNA found in aged analbuminemic rat liver. (1993) (2)
Interactions with cellular macromolecules. (2000) (2)
Identification of N-2- -2-amino-3,8-dimethylimidazo quinoxaline 3,5-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx (1993) (2)
Analysis of the Major RNA Adduct Derived from Aminophenylnorharman, a Novel Endogenous Mutagen and Carcinogen (2007) (2)
ABNORMAL DIFFERENTIATION OF HUMAN GASTRIC EPITHELIUM (1975) (2)
Formation of MeIQx and another mutagen by heating a mixture of creatinine, glucose and glycine (1984) (2)
Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice (2002) (2)
Report of the fifteenth international symposium of the foundation for promotion of cancer research: new horizons in the diagnosis and treatment of hematological malignancies based on molecular genetic features. (2002) (2)
Report of the 16th International Symposium of the Foundation for Promotion of Cancer Research: Recent advances in pancreatic cancer. (2003) (2)
Establishment of the concept that cancer is a disease of DNA: Serendipitous discoveries in my research career concerning the science of carcinogenesis (2004) (2)
Linkage mapping of the rat poly(ADP-ribose) glycohydrolase (Parg) gene to chromosome 16. (1999) (1)
Surface membrane of a non-transplantable variant of mouse mammary carcinoma cells in culture examined by field-emission scanning electron microscopy. (1974) (1)
Early Stage Colon Carcinogenesis Up-regulated in Human Colon Cancers and Implicated in SND 1 , a Component of RNA-Induced Silencing Complex (2007) (1)
cDNA cloning of serine/threonine phosphatase catalytic subunits and reversion of the malignant phenotype to the normal phenotype by okadaic acid, a protein phosphatase inhibitor. (1993) (1)
Oncogenes of stomach cancers. (1990) (1)
Marked formation of thioproline, an effective nitrite trapping agent in vivo, in boiled djenkol beans (Indonesian edible beans) (1991) (1)
[Formation of poly ADP-ribose from NAD by nuclear enzyme preparations]. (1968) (1)
Cancers Methylation and Loss of Heterozygosity in Human Gastric Is a Tumor Suppressor Gene Inactivated by Lysyl Oxidase (2004) (1)
Experimental tumors in digestive organs (2007) (1)
Immunochemical studies on liver catalase depression by toxohormone. (1967) (1)
[TUMOR TOXOHORMONE UNRELATED TO BACTERIAL CONTAMINATION]. (1964) (1)
Cloning of rat Brca2 and linkage mapping to Chromosome 12 (2009) (1)
New thoughts on carcinogenic risk assessment of environmental chemicals. (1994) (1)
Structure of HTLV and its biological function in leukemogenesis of adult T-cell leukemia. (1986) (1)
Modulation of mutagenicity and carcinogenicity. (2000) (1)
Purification andCharacterization ofHumanPapillomavirus Type16E7Protein withPreferential Binding Capacity tothe Underphosphorylated (1991) (1)
Panel Discussion: Nutrition and Cancer Conference (1992) (1)
Analysis by in vitro mutagenesis of PP2A alpha okadaic acid responsive sequences. (1995) (1)
Significant enhancement of Helicobacter pyloriinduced gastritis by fish meal in mongolian gerbils (2000) (1)
Dietary Genotoxins and Cancer (2007) (1)
Report of the Fourteenth International Symposium of the Foundation for Promotion of Cancer Research: Pain Control, Palliative Medicine and Psycho-oncology. (2001) (1)
Formation and removal of DNA adducts in the liver of rats treated with MeIQx (1991) (1)
Isolation and structural determination of a mutagenic substance in creatine pyrolysate (1991) (1)
Quantification of heterocyclic amines in cooked foods (1986) (1)
Absence ofalbumin mRNA intheliver ofanalbuminemic rats (1980) (1)
Meeting on carcinogen testing is open (1979) (1)
Role of prostanoid receptors in colon carcinogenesis (1999) (1)
ICPEMC News No. 2 (1980) (1)
Susceptibility and resistance genes to MNNG-induced stomach carcinogenesis (1999) (1)
Relation between the structures of ingenol esters and their ornithine decarboxylase-inducing activities in mouse skin. (1982) (1)
[Progress in studies of experimental stomach cancer induced by nitrosoguanidine]. (1970) (1)
Tyramine as a major precursor of mutagen which becomes mutagenic in soy sauce after nitrite treatment (1984) (1)
Toward targeted killing of tumor-specific antigen-producing cancer cells by retrovirus displaying a single chain variable fragment antibody. (1998) (1)
Purification and characterization of poly(ADP-ribose) polymerase from Sarcophaga peregrina (2002) (1)
Helicobacter pylori Extracts Exhibit Nicotinamide Adenine Dinucleotide‐derived Adenylation but Not Mono(adenosine 5‐diphosphate‐ribosyOation of DNA Ligase (1997) (1)
Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3. (2001) (1)
Linkage Mapping of the Bra, Brb and Brg Genes for Rat Protein Phosphatase 2A 55 kDa B‐Regulatory Subunit Isotypes (1998) (1)
[Induction of respiration-deficient mutants of Candida utilis]. (1970) (1)
Metabolism of mutagenic amino-gamma-carbolines in tryptophan pyrolysates. (1981) (1)
Kinetic studies on the liver catalase depression in vivo using 3,5-dicarbethoxy-1,4-dihydrocollidine. (1965) (1)
[The principles of cancer treatment--changes in chemotherapy]. (2002) (1)
Nucleotide sequences homologous to human T-cell leukemia virus are present in pig and wild boar cells. (1984) (1)
Identification by a random linker insertion method of a region which suppresses the transforming activity of the raf oncogene. (1988) (1)
CHEMICAL CONFIRMATION OF THE STRUCTURE OF A MUTAGENIC AMINOPHENYLNORHARMAN, 9-(4'-AMINOPHENYL)-9H-PYRIDO[3,4-b]INDOLE: AN AUTHENTIC SYNTHESIS OF 9-(4'-NITROPHENYL)-9H- PYRIDO[3,4-b]INDOLE AS ITS RELAY COMPOUND (2010) (1)
Mutagenicity of okadaic acid on cultured Chinese hamster cells (1991) (1)
Linkage mapping of the rat Msh2 DNA mismatch repair gene on chromosome 6. (1999) (1)
Oncogenes activated in tumors induced by environmental mutagens (1986) (1)
Distinct responses of 3T3-L1 cells to dihydroteleocidin B and the phorbol ester tumor promoters: relation to adipocyte differentiation, DNA synthesis and cell division. (1983) (1)
A 13C NMR study of poly(adenosine diphosphate ribose) and its monomers: evidence of cl-(1"-^ 2') ribofuranosyl ribofuranoside residue (1)
Linkage mapping of rat Rb1 gene on Chromosome 15 (1997) (1)
THE METABOLLSM OF 4-NITROQUINOLINE 1-OXIDE (1965) (1)
QUANTITATIVE STUDIES ON THE FRACTIONATION OF CARCINOSTATIC LIVER FACTOR. (1963) (1)
What is the role of environmental mutagens for human cancer development? (1986) (1)
Chapter 31 – Systemic Lupus Erythematosus (1982) (1)
Genetic alterations in rat colon tumors induced by heterocyclic amines (1)
Increase in frequency of appearance of cadmium-resistant cells induced by various tumor promoters; evidence for the induction of gene amplification. (1983) (1)
Antipromoter activity of CV-3611, a scavenger of active oxygen, in bladder carcinogenesis (1991) (0)
The presence ofmRNAs for vascular endothelial growth factor (VEGF) and a VEGF-related protein, placenta growth factor (PIGF) was examined in 29 cases of renal cell carcinoma tissues and adjacent normal kidney (2006) (0)
Mutagenicities of river water in Bangkok, Tokyo and Kyoto (1995) (0)
Glycolysis of spleen of mice infected with friend virus. (1961) (0)
ADP-Ribosylation of Human c-Ha-ras Protein by Hen Liver ADP-Ribosyl Transferase (1989) (0)
Highly Sensitive Method for Immunohistochemical Detection of Poly(ADP-Ribose) in Various Animal Species (1989) (0)
Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II ( retrovirus / DNA sequence / transcription ) (0)
The presence of cytotoxic proteins in females of subfamily Arctiinae moths (2001) (0)
Advances in Brief Messenger RNA Levels of Five Genes Located at Chromosome l lq13 in B-Cell Tumors with Chromosome Translocation t(ll;14)(q13;q32) 1 (2007) (0)
P XIII.43 Isolation of mutagens in water from the Nishitakase river in Kyoto (1997) (0)
P XVII B.6 Formation of a coupled mutagenic compound from the co-mutagen, norharman with aniline (1997) (0)
SYNTHESES OF POTENT MUTAGENS IN TRYPTOPHAN PYROLYZATES (1978) (0)
[Decarcinogenesis and carcinostasis]. (1970) (0)
New Biological Significance of Indole-Containing Compounds as Initiators or Tumor Promoters in Chemical Carcinogenesis (1984) (0)
Editorial: What Is the Role of Environmental Health Science in Cancer Prevention? (1994) (0)
Reversion of transformed NIH 3T3 cells to flat cells by inhibitors of poly(ADP-ribose) polymerase. (1990) (0)
Corrections - Separation of Oligio(adenosine diphosphate ribose) Fractions with Various Chain Lengths and Terminal Structures (1977) (0)
A POTENT MUTAGEN IN BROILED FISH. PART 1. 2-AMINO-3-METHYL-3H-IMIDAZO(4,5-F)QUINOLINE (1981) (0)
Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors. (1988) (0)
Aberrant DNA methylation on chromosome 16 is an early event in hepatocarinogenesis (1997) (0)
Environmental mutagen society of Japan selected abstracts of the 23rd annual meeting (1996) (0)
[Rheumatism and poly(ADP-ribose)]. (2003) (0)
Requirement of cofactor for triphenyltetrazolium chloride reduction by succinic dehydrogenase. (1956) (0)
Isolation and identification of mutagen present in water of the Waka River (1999) (0)
[Cancer research avenues paved from oblivion]. (2000) (0)
Isolation of a potent mutagen from cooked beef (1980) (0)
Specifi ' c 5 '-GGGA-3 '-* 5 '-GGA-3 ' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo [ 4 , 5b ] pyridine ( colorectal neoplasms / heterocyclic amines / fingerprinting ) (2005) (0)
Inhibition of human brain monoamine oxidase by heterocyclic amines (1989) (0)
Phylo genie distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)- (2006) (0)
Oncogene of sarcomas induced by 1,8-dinitropyrene in rats (1985) (0)
Two-DimensionaL Electrophoretic Analysis of Cellular Polypeptides from Livers of LEC Rats (1991) (0)
Reaction of N-hydroxy derivatives of heterocyclic amines with DNA (1988) (0)
Ferritin content of the liver of tumor-bearing animals. (1957) (0)
Binding of Ricinus communis agglutinin on non-tumorigenic variants of mouse mammary carcinoma cells in culture. (1973) (0)
[Oncogenes and anti-oncogenes in carcinogenesis]. (1990) (0)
Deoxyaldolase activity in neoplastic tissue. (1957) (0)
SYNTHESIS OF 2-AMINO-3,8-DIMETHYLIMIDAZO(4,5-F)QUINOXALINE (ME-IQX), A POTENT MUTAGEN ISOLATED FROM FRIED BEEF (1981) (0)
P XVI A.6 Analysis of carcinogenic heterocyclic amine-DNA adducts in human tissues (1997) (0)
Risk Assessment of Naturally Occurring Carcinogens (1991) (0)
Congratulatory dedication to Professor Osamu Hayaishi: From Bethesda to Ueno Park (Japan Academy) (2006) (0)
[The relationship between oncogenes and chromosome abnormalities in the pathogenesis and progression of lung cancer]. (1989) (0)
Nucleotide sequence analysis of th( T-cell leukemia virus type II (retrovirus/DNA sequence/transcription) (2016) (0)
Analysis of a new mutagen (PBTA-4) in river water samples in Fukui and Kyoto prefectures (1999) (0)
Mutagenicities of base analogues, 2-amino-N6-hydroxyadenine and N4-aminocytidine, in Chinese hamster lung cells with diphtheria toxin resistance as a selective marker (1991) (0)
32P-postlabeling analysis of DNA adduct, N2-acetyl derivative of guanine, formed in vitro by the combination of methylglyoxal and hydrogen peroxide (1992) (0)
Issue Information (2020) (0)
[Biochemical studies on the phenotype of cancer cells]. (1966) (0)
[MICROSOMES OF HEPATOMA CELL LINES]. (1965) (0)
Mutagen formed by heating of mixtures of guanidino compounds, amino acids and glucose (1996) (0)
Shichiro Ishikawa, M.D. (1910-1986). (1986) (0)
INACTIVATION OF FRIEND VIRUS BY SNAKE VENOM. (1964) (0)
[Biogenetic deviation and reversion of cancer cells]. (1970) (0)
Poly(ADP-nbose). Historical perspective (1994) (0)
Human exposure level of heterocyclic amines and their risk assessment (1991) (0)
[MECHANISM OF THE DEVELOPMENT OF CANCER]. (1964) (0)
Contents Vol. 64, 2003 (2003) (0)
Takashi Tsuruo (2009) (0)
stance, and nitrite-related materials, polycyclic aromatic hydrocarbons and oxidative agents. Emphasis has been increasing in advanced nations. Furthermore, the mutation (2000) (0)
Presence of nitrosable mutagen precursors in heated foods (1987) (0)
DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form (2017) (0)
Agencies supporting cancer research in Japan. (1992) (0)
Ferritin Content in Liver of Tumor-bearing Animal (1956) (0)
Some aspects of the mode of action of the carcinostatic liver factor active in vitro. (1965) (0)
In memoriam: Dr. Waro Nakahara. (1976) (0)
Author reply (0)
Coenzyme Q10 Suppression of AOM-induced Rat Colonic Premalignant Lesions (0)
[Natural carcinogens: hepatic cancer in the rainbow trout, with special reference to aldolase activities]. (1972) (0)
[Studies on thymic involution in tumor bearing animals]. (1957) (0)
LRP130: A possible effector of the mTOR-mediated mRNA translation (2005) (0)
Presence of albumin mRNA precul rat liver lacking cytoplasmic albun (analbuminemia/RNA'cDNA hybridization kinetics/SI nuclease map (2016) (0)
Obituary. Dr. Waro Nakahara (1976) (0)
Isolation and identification of two new mutagens in beef extract (1995) (0)
Perspectives in Food Mutagen Research (2018) (0)
[Adult T-cell leukemia with vertebral bone tumor and acute transverse myelopathy]. (1989) (0)
In vitro Transformation o f Hamster Embryo Cells with Try ptophan Pyrolysis Products (2006) (0)
Electrophoretic and immunological properties of liver alpha-amylase of well-fed and fasted rats. (1975) (0)
Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant (1999) (0)
Dr. Waro Nakahara (1976) (0)
Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells (2004) (0)
Successful IFN therapy for reactivation of hepatitis B virus infection induced by steroid therapy in a patient with polymyositis. (1992) (0)
The alkylating agent MNNG is both a potent mutagen and a carcinogen. In the Salmonella test system, 0.02 mole of MNNG (2006) (0)
Suppressed Tumorigenicity-transduced Pancreatic Cancer Cells with ras Antisense K-Identification of Genes Showing Differential Expression in Updated (1999) (0)
Studies on the Biosynthesis of the Ubiquinone (Coenzyme Q) Series in Animals and Micro‐Organisms (2008) (0)
Mutagen, carcinogen and tumor promoter in daily life. (1989) (0)
DECREASE OF CARCINOSTATIC LIVER FACTOR IN TUMOR-BEARING ANIMALS. (1964) (0)
X-RAY DIAGNOSIS OF CANCER IN THE GLANDULAR STOMACH OF RATS*1 (2008) (0)
Metabolic Aspects of Pyrolysis Mutagens in (2016) (0)
Inactivation of Pyrolysate Mutagens by Nitrite and by Chlorinated Tap Water (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology) (1982) (0)
Regression and prevention of autochthonous tumors induced by 3-methylcholanthrene after injection of a T-cell receptor alpha /beta positive and CD4/CD8 double negative T-cells. (1999) (0)
DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ (2017) (0)
Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism (2007) (0)
Markedincreases oftwokindsoftwo-exon-skipped albumin mRNAs withagingandtheir further increase bytreatment with (1991) (0)
[CANCER AND NUCLEIC ACIDS]. (1963) (0)
[Aging and cancer]. (1995) (0)
Single-Strand Conformation Polymorphism Analysis Cancer by Cell Sorting and Polymerase Chain Reaction Gene Mutations in Primary Gastric p 53 Detection of Frequent Updated (2006) (0)
Electrophoresis in cancer research (2000) (0)
Bond Alternation and Mutagenicity of Azulenoquinolines and Diazulenopyridines (1984) (0)
Modification of the ³²P-postlabeling method to detect a single adduct species as a single spot. (2014) (0)
[Recent studies on poly(ADP-Ribose)]. (1976) (0)
Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microsarays (2004) (0)
No Mutation of the Catalase Gene in Cancer Patients (1991) (0)
21WA-03-4 Effects of nonylphenol and atrazine on female reproductive organs of rats in 28-day repeated toxicity study. (1999) (0)
Toxicogenomic approach to the prediction of carcinogenic potentials of heterocyclic amines in rat colon(Analysis of Toxicological Mechanisms : A Toxicogenomics Approach, Proceedings of the 32nd Annual Meeting) (2005) (0)
MeIQ in vivo mutagenesis: Mutational spectra in organs with or without cancer development (1996) (0)
A case of severe acute liver damage due to thinner sniffing. (1990) (0)
Chemopreventive properties of nimesulide, a selective cyclooxygenase-2 inhibitor, against phip-induced mammary carcinogenesis in rats (1999) (0)
MutantofYeast Lacking AllCytochromes andAccumulating Coproporphyrin (2003) (0)
Reply to Letter from Dr. Tokudome (1989) (0)
Her Imperial Highness Princess Takamatsu (1911–2004) (2005) (0)
[Comments on cancer research in Japan (author's transl)]. (1978) (0)
[Aldolase and hexokinase in liver cancer cells]. (1966) (0)
P-075 Analysis of protein adducts derived from N-nitroso bile acid conjugates(Environmental mutagens,Poster Session) (2009) (0)
Prophage lambda induction test (inductest) of anti-tumor antibiotics. (1981) (0)
Lack of Carcinogenic Potential of 9-( 4-Aminophenyl )-9 H-pyrido [ 3 , 4-b ] indole ( aminophenylnorharman ) for the Pancreatic Duct Epithelium in Hamsters (2002) (0)
Photoreactivation of heme-protein lacking yeast. (1967) (0)
Possible Lack of Carcinogenic Potential of 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters (2002) (0)
BASIC—ALIMENTARY TRACT Loss of Adiponectin Promotes Intestinal Carcinogenesis in Min and Wild-type Mice (2011) (0)
Erratum: (Journal of Clinical Investigation (August 1995) 96:2 (1126)) (1995) (0)
Development of the arbitrarily pi analysis method and chromosoma throughput rat genetic markers (2016) (0)
Tumorpromoters blocktyrosine-specifi c phosphorylation ofthe epidermal growth factor receptor (phorbol esters/indole alkaloids/polyacetates/protein (1984) (0)
A novel transforming gene, hst. (1988) (0)
Tumor Promoter-dependent Mouse Leukemia Cell Line 1 (2006) (0)
Regression and prevention of autochthonous tumors induced by 3-methylcholanthrene after injection of a T-cell receptor α/β positive and CD4/CD8 double negative T-cells (1999) (0)
INDUCTION OF δ-AMINOLEVULINIC ACID SYNTHETASE IN CULTURED FRIEND LEUKEMIA CELLS BY DIMETHYL SULFOXIDE AND HUMAN PLACEN- TAL EXTRACT*1 (2008) (0)
Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentaenes (1988) (0)
Ras gene mutations in heterocyclic-amine-induced liver tumours (1991) (0)
[Biochemical variety of mutant yeasts induced by 4-nitroquinoline N-oxide. 2. Change in coenzyme Q6 content]. (1968) (0)
Molecular Aspects of Growth Control (1989) (0)
Molecular cloning and the total nucleotide sequence of the human cHaras-1 gene activated in a melanoma from a Japanese patient ( DNA transfection / human melanoma oncogene / Alu repetitive sequences / point mutation / 61 st codon ) (1999) (0)
Presence of tumor promoters in Jatropha oil of Thailand (1987) (0)
A novel method for detecting intestinal metaplasia of the stomach with Tes-tape(Communication) (1971) (0)
Characterization of an inactivating factor in rat liver cytosol for the mutagenicity of coffee (1984) (0)
DNA targeting ADP-ribosyltransferase Pierisin-1 (2017) (0)
Abstract 2478: Early and enhanced development of N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic adenocarcinomas by high-fat diet (2010) (0)
What is the role of environmental health science in cancer prevention? (1994) (0)
Effect of glucose on the mutagenic sensitivity of Salmonella typhimurium tester strains (1978) (0)
PolyADP-Ribosylation Is Required for Pronuclear Fusion and Nuclear Reprogramming in the Oocytes. (2008) (0)
P VIII.12 Minisatellite rearrangement induced by a tumor promoter, okadaic acid (1997) (0)
Guanidino Compounds, Amino Acids and Glucose (2006) (0)
Rotational temperatures of oxyacetylene converging detonations. II Measurement with OH ultraviolet emissions (1976) (0)
Frequent Alleile Losses and Mutations of the p53 Gene in Human Ovarian Cancer1 (2006) (0)
[Acquisition of toxohormone-like activity by serum constituents following certain chemical treatment]. (1957) (0)
Perinatal Changes of a-Fetoprotein Concentration in the Serum and its Synthesis in the Liver of Analbuminemic Rats1 (2006) (0)
Obituary (2009) (0)
Altered Oncogene Expression in Hepatocellular Carcinomas Developing Spontaneously in LEC Rats (1991) (0)
COLORIMETRIC ASSAY OF EOSIN UPTAKE BY EHRLICH ASCITES CELLS. (1963) (0)
Pioneers of cancer research in Japan. (1991) (0)
Formation of in vivo DNA adduct by administration of 7-OHIQ (1996) (0)
Purification and properties of alpha,alpha-trehalase from the mucosa of rat small intestine. (1975) (0)
Mutagens in foods, and their production by cooking (1978) (0)
Molecular species of aldolase in the liver of tumor-bearing rats. (1969) (0)
Recovery and analysis of MeIQx-DNA adduct by the 32P-postlabeling method (1991) (0)
Characterization ofthePP2Aagenemutation inokadaic acid-resistant variants ofCHO-K1cells (1994) (0)
Proceedings: Effect of poly(ADP-ribose) on DNases of the nuclei of rat liver and ascites hepatoma cells. (1975) (0)
The mechanisms of the loss of tumor-promoting activity due to debromination of aplysiatoxin. Abstr. (1983) (0)
Modification of the 32P-postlabeling method to detect a single adduct species as a single spot. (2005) (0)
ISDN communication : its workstation technology and application system (1991) (0)
Messenger RNA Levels of Five Genes Located at Chromosome l lq 13 in B-Cell Tumors with Chromosome Translocation t ( ll ; 14 ) ( q 13 ; q 32 ) 1 (2007) (0)
RAPID COMMUNICATION (1997) (0)
Nitrite converts 2-amino-alpha-carboline, an indirect mutagen, into 2-hydroxy-alpha-carboline, a non-mutagen, and 2-hydroxy-3-nitroso-alpha-carboline, a direct mutagen. (1981) (0)
Occurrence of multiforms of alpha-amylase, new isozymes or autodigested forms. (1975) (0)
Improvement of the Spi assay for gpt delta mice by including magnesium ions during plaque formation (2002) (0)
History of the Discovery of Poly (ADP-ribose) (2015) (0)
Formation of DNA adduct by MeIQx: relation between administration dose and adduct level (1991) (0)
SYNTHESIS AND MUTAGENICITY OF 10-AZABENZO(α)PYRENE 4,5-OXIDE AND OTHER PENTACYCLIC AZA-ARENE OXIDES (1978) (0)
Subject Index Vol. 64, 2003 (2003) (0)
Mammary Cancer (2021) (0)
Proceedings of the International Symposia of the Princess Takamatsu Cancer Research Fund, Volume 13 ADP-Ribosylation, DNA Repair and Cancer : Proceedings of the International Symposia of the Princess Takamatsu Cancer Research Fund, Volume 13 (2020) (0)
[Topics in recent cancer research (author's transl)]. (1978) (0)
Inhibition of Protein SerinelThreonine Phosphatases by Fumonisin 8 1 , a Mycotoxin (2007) (0)
Effect of methyl substitution on mutagenicity of 2-aminodipyrido. (1980) (0)
P-071 Genotoxicity of nanoparticles in in vivo assay systems(Poster Session) (2008) (0)
[Experimental gastrointestinal neoplasms]. (1976) (0)

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