Takashi Tokino
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Computer Science
Takashi Tokino's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Takashi Tokino's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- WAF1, a potential mediator of p53 tumor suppression (1993) (8623)
- Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. (2000) (2112)
- p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53 (2000) (1214)
- p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. (1995) (1140)
- Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer (2004) (1075)
- AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 (2000) (968)
- Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. (1992) (741)
- Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (2008) (625)
- Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. (1995) (622)
- p53 Mutation and MDM2 amplification in human soft tissue sarcomas. (1993) (563)
- Sequence-specific transcriptional activation is essential for growth suppression by p53. (1994) (423)
- Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line* (1997) (410)
- Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage (1996) (352)
- Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. (2012) (345)
- A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis (1997) (296)
- Inherited p53 gene mutations in breast cancer. (1992) (271)
- Allelotype study of primary hepatocellular carcinoma. (1991) (249)
- Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer (2008) (236)
- Epigenetic inactivation of CHFR in human tumors (2003) (206)
- The p53 Family Member Genes Are Involved in the Notch Signal Pathway* (2002) (201)
- Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. (2010) (200)
- The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. (1987) (193)
- p53 tagged sites from human genomic DNA. (1994) (186)
- Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis. (1990) (178)
- The role of p53-target genes in human cancer. (2000) (175)
- Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. (2007) (167)
- Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein–Barr virus (2006) (166)
- Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. (2002) (163)
- Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer. (2011) (160)
- Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005) (156)
- The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (2005) (153)
- Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer (2007) (147)
- ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes (2003) (140)
- Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells (1999) (133)
- Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors (2002) (128)
- Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. (1999) (124)
- Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma (2008) (120)
- Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. (2003) (118)
- The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors (2002) (112)
- Isolation and mapping of 62 new RFLP markers on human chromosome 11. (1991) (111)
- Gene amplification and overexpression of PRDM14 in breast cancers. (2007) (108)
- Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas (1987) (107)
- CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress. (1998) (107)
- Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours (2005) (107)
- DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. (2008) (106)
- DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers (2002) (105)
- Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (1997) (105)
- Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006) (104)
- IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010) (103)
- Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells (2004) (103)
- Mutations of the β‐Catenin Gene in Endometrial Carcinomas (1999) (102)
- Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (1998) (99)
- Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 (1999) (96)
- A Single Nucleotide Polymorphism in the Matrix Metalloproteinase‐1 Promoter in Endometrial Carcinomas (2000) (96)
- Cloning of P2XM, a novel human P2X receptor gene regulated by p53. (1997) (95)
- Epigenetic Inactivation of TMS1/ASC in Ovarian Cancer (2004) (94)
- CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation* (2012) (93)
- Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer. (2013) (87)
- PRDM5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer (2007) (86)
- deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. (2003) (85)
- A Novel Correlation between LINE-1 Hypomethylation and the Malignancy of Gastrointestinal Stromal Tumors (2010) (84)
- Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. (1992) (84)
- Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer (2010) (82)
- Mutational Analysis of β‐Catenin Gene in Japanese Ovarian Carcinomas: Frequent Mutations in Endometrioid Carcinomas (1999) (81)
- Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphisms. (1992) (80)
- Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma (1991) (75)
- Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006) (72)
- Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. (2007) (72)
- Long non‐coding RNA NEAT1 is a transcriptional target of p53 and modulates p53‐induced transactivation and tumor‐suppressor function (2017) (72)
- Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. (2003) (72)
- Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype. (2012) (72)
- Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation (2017) (71)
- Upregulation of BNIP3 by 5-aza-2′-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death (2005) (69)
- Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy (2009) (69)
- Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma (2009) (67)
- Aberrant Methylation and Histone Deacetylation Associated with Silencing of SLC5A8 in Gastric Cancer (2004) (67)
- A Single Recombinant Adenovirus Expressing p53 and p21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells (2009) (65)
- Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-κB–mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis (2011) (64)
- Identification of SCN3B as a novel p53-inducible proapoptotic gene (2004) (63)
- Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma. (1988) (63)
- Adenovirus‐mediated Transfer of p53‐related Genes Induces Apoptosis of Human Cancer Cells (2000) (62)
- Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma (2006) (62)
- Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. (2006) (61)
- A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth (2009) (60)
- Identification of the Osteopontin gene as a direct target of TP53 (2002) (60)
- LINE-1 Hypomethylation Is Associated with Increased CpG Island Methylation in Helicobacter pylori–Related Enlarged-Fold Gastritis (2008) (59)
- Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer (2001) (58)
- Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes (2005) (58)
- A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. (2008) (58)
- Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines (2006) (57)
- Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. (1996) (57)
- Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. (1998) (56)
- Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness (2014) (55)
- CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion (2012) (55)
- Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-γ in haematopoietic tumour cells (2004) (54)
- AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis (2013) (52)
- DNA methyltransferase 1 is essential for initiation of the colon cancers. (2013) (52)
- High resolution ordering of DNA markers by multi-color fluorescent in situ hybridization of prophase chromosomes. (1994) (50)
- Antiangiogenic activity of BAI1 in vivo: implications for gene therapy of human glioblastomas (2006) (50)
- p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage (2007) (49)
- Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors (2005) (49)
- MicroRNA‐31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions (2014) (49)
- Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing. (2016) (48)
- Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005) (48)
- Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 (2018) (47)
- DNA methylation and cancer pathways in gastrointestinal tumors. (2008) (46)
- DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae (2010) (44)
- Characterization of the human p57KIP2 gene: Alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis (1996) (44)
- Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma (2012) (44)
- Induction of tenascin‐C by tumor‐specific EWS‐ETS fusion genes (2003) (43)
- Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer (2008) (42)
- Mutation of the SRC Gene in Endometrial Carcinoma (2000) (42)
- Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines (2007) (41)
- Histone Deacetylation, But Not Hypermethylation, Modifies Class II Transactivator and MHC Class II Gene Expression in Squamous Cell Carcinomas1 (2003) (41)
- Mapping of 262 DNA markers into 24 intervals on human chromosome 11. (1992) (40)
- Induction of Cellular Genes Is Mediated by the Bel1 Transactivator in Foamy Virus-Infected Human Cells (2000) (40)
- Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNA (1999) (38)
- Mutational Analysis of the β-Catenin Gene in Gastric Carcinomas (2000) (38)
- Upregulation of miR-196 a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors (2012) (37)
- Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1 (1999) (36)
- One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations. (2015) (36)
- A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer (2016) (36)
- Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma (2008) (35)
- Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53. (1997) (35)
- Purification and properties of the mini-F plasmid-encoded E protein needed for autonomous replication control of the plasmid. (1986) (34)
- Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma (2012) (34)
- Microdeletion associated with the integration process of hepatitis B virus DNA. (1988) (33)
- Identification of Flotillin-2, a Major Protein on Lipid Rafts, as a Novel Target of p53 Family Members (2008) (33)
- Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites. (2014) (33)
- Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors (2015) (32)
- Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors (2011) (32)
- Identification of the interleukin 4 receptor alpha gene as a direct target for p73. (2003) (32)
- Interactive web-based graphs of novel coronavirus COVID-19 cases and deaths per population by country (2020) (32)
- Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy (2015) (31)
- Chromosome deletions associated with hepatitis B virus integration. (1991) (31)
- A high-resolution cytogenetic map of 168 cosmid DNA markers for human chromosome 11. (1992) (31)
- Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Polı gene as a candidate for Par2 (2003) (30)
- Isolation and mapping of 68 RFLP markers on human chromosome 6. (1992) (30)
- Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. (1996) (29)
- Detailed analysis of an amplified region at chromosome 11q13 in malignant tumors. (1992) (29)
- Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis (2005) (29)
- Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer (2012) (29)
- Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma (2018) (28)
- Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer (2018) (28)
- A 14-Mb physical map of the region at chromosome 11q13 harboring the MEN1 locus and the tumor amplicon region. (1992) (27)
- Association between chromosome 11q13 amplification and prognosis of patients with oesophageal carcinomas. (1992) (27)
- Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing (2017) (26)
- Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress (2016) (26)
- p53 Family Members Regulate the Expression of the Apolipoprotein D Gene* (2009) (26)
- Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. (2017) (25)
- DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling (2018) (25)
- p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. (2017) (24)
- Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation (2005) (24)
- p53 negatively regulates the hepatoma growth factor HDGF. (2011) (24)
- Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma (2018) (24)
- CRKL oncogene is downregulated by p53 through miR-200s (2015) (23)
- GML sensitizes cancer cells to Taxol by induction of apoptosis (1997) (22)
- Mutational analysis of the beta-catenin gene in gastric carcinomas. (2001) (22)
- Mutational Analysis of STK11 h Gene in Ovarian Carcinomas (1999) (22)
- Overexpression of GML promotes radiation-induced cell cycle arrest and apoptosis. (1997) (22)
- Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models (2008) (22)
- A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors (2019) (21)
- Regulation of MHC class II expression in glioma cells by class II transactivator (CIITA) (2004) (21)
- Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer (2019) (19)
- Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene. (2010) (19)
- Significant increase of adenovirus infectivity in glioma cell lines by extracellular domain of hCAR. (1999) (18)
- Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer. (2015) (18)
- Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53 (2017) (17)
- Induction of apoptosis in melanoma cell lines by p53 and its related proteins. (2001) (17)
- Induction of apoptosis in T98G glioblastoma cells by transfection of GML, a p53 target gene. (1999) (17)
- Definition of the locus responsible for systemic carnitine deficiency within a 1.6-cM region of mouse chromosome 11 by detailed linkage analysis. (1996) (17)
- UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells (2019) (16)
- The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005) (16)
- Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo (2021) (16)
- Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors (2017) (16)
- Mutational analysis of the hMLH1 gene using an automated two‐dimensional DNA typing system (1997) (16)
- Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity (2009) (15)
- A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors (2015) (15)
- Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma (2022) (15)
- Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy (2018) (14)
- Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment. (2018) (14)
- Retrovirus vectors designed for efficient transduction of cytotoxic or cytostatic genes (1999) (14)
- Cloning and characterization of the murine P2XM receptor gene (1998) (14)
- Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer (2008) (14)
- The 11q23 breakpoint in acute leukemia with t(11;19)(q23;p13) is distal to those of t(4;11), t(6;11) and t(9;11) (1992) (13)
- Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy. (2020) (13)
- FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy (2019) (12)
- Physical mapping of a 950-kb region surrounding a locus (D10S102) tightly linked to the MEN2A gene. (1992) (12)
- Advances in Brief p 53 Mutation and MDM 2 Amplification in Human Soft Tissue Sarcomas 1 (2006) (12)
- Contribution of Caspase‐3 Differs by p53 Status in Apoptosis Induced by X‐Irradiation (2001) (12)
- Integrated genetic and epigenetic analysis of cancer‐related genes in non‐ampullary duodenal adenomas and intramucosal adenocarcinomas (2020) (12)
- TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells (2016) (11)
- Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes (2012) (11)
- Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing (2015) (11)
- Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis (2019) (10)
- No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. (1997) (10)
- DNA methylation changes in gastrointestinal disease (2002) (10)
- PRDM 5 Identified as a Target of Epigenetic Silencing in Colorectal and Gastric Cancer (2007) (10)
- Identification and characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a locus (D1OS102) closely linked to MEN2 (multiple endocrine neoplasia type 2) (1993) (9)
- A full genome scan for gastric cancer (2005) (9)
- Combination of KRAS and SMAD4 mutations in formalin‐fixed paraffin‐embedded tissues as a biomarker for pancreatic cancer (2020) (9)
- A novel approach to cancer treatment using structural hybrids of the p53 gene family (2012) (8)
- Regional localization of the LCA oncogene to human chromosome region 2q14----q21. (1988) (8)
- Aberrant Methylation of RASGRF 1 Is Associated with an Epigenetic Field Defect and IncreasedRisk of Gastric Cancer (2012) (8)
- In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. (2008) (8)
- Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target (2016) (8)
- Candidate Mediator of p 53-Induced Apoptosis Noxa , a BH 3-Only Member of the Bcl-2 Family (2010) (7)
- Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. (2005) (7)
- Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells (2014) (7)
- Aberrant laminin beta-3 isoforms downstream of EWS-ETS fusion genes in ewing family tumors (2005) (7)
- Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer (2021) (7)
- Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum (2020) (6)
- The effect of forced expression of mutated K‐RAS gene on gastrointestinal cancer cell lines and the IGF‐1R targeting therapy (2017) (6)
- The functional relation of vitamin D receptor and p53 in cancer cells. (2006) (6)
- Isolation and characterization of a novel TP53‐inducible gene, TP53TG5, which suppresses growth and shows cell cycle‐dependent transition of expression (2000) (5)
- Identification of 57 conventional RFLP and 6 VNTR systems with 32 DNA clones on chromosome 11p15. (1992) (5)
- Precise Localization of a Gene Responsible for Ataxia-Telangiectasia on Chromosome 11q (1993) (5)
- P53 pathway and cancer: From bench to clinic (2015) (5)
- A novel biomarker for cervical cancer (2009) (5)
- Absence of germline prohibitin mutations in early-onset breast-cancer. (1993) (5)
- Carrier detection in Japanese haemophilia A families using factor VIII gene probe (F8A) and the gene-linked ST 14-1 probe (1987) (5)
- Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma (2022) (4)
- Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors (2018) (4)
- Frequent tumor burden monitoring of esophageal squamous cell carcinoma with circulating tumor DNA using individually designed digital PCR (2020) (4)
- Isolation and Mapping of 62 New RFLP Markers on Human Chromosome I I (2006) (4)
- Low-grade mucoepidermoid carcinoma with regional lymph node metastasis: A case report and genetic review of criteria for grading (2016) (4)
- Detection of human papillomavirus DNA by PCR/microfluorometry for screening of cervical cancer. (2002) (4)
- Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-γ in haematopoietic tumour cells (2004) (4)
- Assignment of fifty-four cosmid clones to five regions of chromosome 10. (1993) (4)
- Mutation Analysis of Radioresistant Early-Stage Cervical Cancer (2021) (3)
- Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH) (2019) (3)
- Corrigendum to “Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer” (2019) (3)
- Multistep Carcinogenesis of Esophageal Carcinoma (1997) (3)
- [Tumor suppressor gene p53]. (1996) (3)
- Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs (2017) (3)
- Mapping the breakpoint of a constitutional translocation on chromosome 22 in a patient with NF2 (1993) (3)
- Fifty novel sequence-tagged sites (STSs) on human chromosome 11q13.4-->q25 identified from microclones generated by microdissection. (1995) (3)
- Dual role of p53 in DNA binding (2004) (2)
- Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients. (2019) (2)
- Thirty-one new RFLP systems detected by twenty-four DNA markers on human chromosome 10. (1992) (2)
- Replication of mini-F plasmid in vitro promoted by purified E protein (1987) (2)
- p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p53 (2019) (2)
- Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p 53 target (2016) (2)
- Genetic analyses of a secondary poroma and trichoblastoma in a HRAS‐mutated sebaceous nevus (2021) (2)
- ALK-positive atypical Spitz tumour with conspicuous rosette-like structures (2021) (2)
- Advances in Brief Inherited p 53 Gene Mutations in Breast Cancer 1 (2006) (2)
- Correction: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma (2013) (2)
- Generation of mouse hepatobiliary organoids from hepatocyte progenitors and cholangiocytes isolated from healthy adult mouse liver (2021) (1)
- Fledglings in p53 signaling network (2017) (1)
- Identification and characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a locus (D10S102) closely linked to MEN2 (multiple endocrine neoplasia type 2). (1993) (1)
- Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy (2020) (1)
- DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes (2021) (1)
- DOWNREGULATION OF MIR‐200B IS ASSOCIATED WITH CISPLATIN‐RESISTANCE IN BLADDER CANCER CELLS: MP44‐14 (2017) (1)
- Abstract 90: A comprehensive analysis to screen for epigenetically silenced miRNA genes in colorectal cancer (2011) (1)
- Abstract 3707: Semiconductor-based next-generation sequencing analysis of 409 cancer-related genes for mutations and copy-number variations in oral squamous cell carcinoma (2016) (1)
- Chromosome regional mapping for the human thyroid stimulating hormone beta subunit (TSHB) gene. (1990) (1)
- Cancer Genomics and Molecular Diagnosis—The Nineteenth International Symposium of Sapporo Cancer Seminar (1999) (1)
- Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs (2020) (1)
- Genetic analyses of mosaic neurofibromatosis type 1 with giant café‐au‐lait macule, plexiform neurofibroma and multiple melanocytic nevi (2020) (1)
- AKR 1 B 10 , a transcriptional target of p 53 , is Downregulated in Colorectal Cancers Associated with Poor Prognosis (2013) (1)
- Abstract 3649: Targeted sequencing of 409 cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencers (2016) (0)
- Clinicopathological features of gastric cancer with CpG island methylator phenotype and its association to Epstein-Barr virus (2005) (0)
- Abstract 598: Forkhead transcription factor FOXF1 is a novel p53 target gene and regulates cancer cell migration and invasion (2014) (0)
- 2E1412 Single-molecule structural analysis of tumor suppressor p53 using scanning probe microscopes(Proteins:Property II,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan) (2012) (0)
- Clinical Cancer esearch an Cancer Biology ovel Correlation between LINE-1 Hypomethylation and R Malignancy of Gastrointestinal Stromal Tumors (2010) (0)
- Genomic characterization for familial cases with urothelial carcinoma (2019) (0)
- Generation of functional liver tissue by establishing hepatobiliary connections ex vivo (2020) (0)
- Methylated CpG Island Amplification of Representational Difference Analysis for Oral Cancer (2002) (0)
- Dead or alive? Pitfall of survival analysis with TCGA datasets (2021) (0)
- Abstract LB-069: Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 family target (2015) (0)
- Abstract 4945: Epigenetic silencing of microRNA-34b/c in human gastric cancer (2010) (0)
- Molecular and Cellular Pathobiology p 53 Negatively Regulates the Hepatoma Growth Factor HDGF (2011) (0)
- Abstract 3070: CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-κB (2010) (0)
- Proteins interacting with CHFR, mitotic-checkpoint ubiquitin ligase (2006) (0)
- The histone deacetylase inhibitor FK228 increases the efficacy of adenovirus-mediated p53 family gene therapy in in Vitro and in Vivo human cancer models (2005) (0)
- Neurofibromatosis type 1 without cutaneous neurofibromas: a rare genotype-phenotype correlation? (2020) (0)
- Abstract 5405: Apoptosis induction in cancer cells by the simultaneous transduction of p53 and artificial miRNAs based on the screening of genome-wide shRNA library (2011) (0)
- Abstract 3188: Targeted semiconductor sequencing of 409 cancer-related genes for somatic mutations and copy number variations in multiple myeloma (2016) (0)
- The global identification of non coding RNA regulated by p53 (2007) (0)
- Erratum: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity (International Journal of Cancer 124 (2607-2615)) (2011) (0)
- Identification of CABIN1-beta as a novel target of epigenetic inactivation in gastric cancer (2005) (0)
- Abstract 553: p53 target BRMS1A is a metastatic suppressor (2018) (0)
- Different type of hepatitis B virus (HBV) DNA integrants that may reflect the integration process (1990) (0)
- CHFR as a Potential Anticancer Target (2008) (0)
- Abstract 4424: Molecular diagnostics of drug resistant multiple myeloma cases using targeted next generation sequencing (2015) (0)
- Abstract 1832: Integrated analysis of clinical ChIPSeq data and public databases identified candidate long non-coding RNAs critically involved in gastrointestinal cancer. (2013) (0)
- Abstract 2968: The functional relationship between CHFR and PARP-1 controls the antephase checkpoint and tumor development (2011) (0)
- Abstract 3687: p53 downregulates CRKL oncogene through miR-200 (2016) (0)
- Dysregulation of mitotic checkpoint proteins Chfr and Aurora A in HTLV-I-infected T-cells (2007) (0)
- A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors (2019) (0)
- RAPID COMMUNICATION (1992) (0)
- Abstract 5308: BRMS1L, a metastatic suppressor gene, is transcriptionally regulated by p53 (2019) (0)
- Cancer Therapy : Preclinical A Single Recombinant Adenovirus Expressing p 53 and p 21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells (2009) (0)
- Abstract 4905: Comprehensive genomic analyses of oral squamous cell carcinoma tissues by semiconductor-based next-generation sequencing (2015) (0)
- Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 (2018) (0)
- Expression in Squamous Cell Carcinomas Transactivator and MHC Class II Gene Hypermethylation, Modifies Class II Histone Deacetylation, But Not (2003) (0)
- Nucleic Acids Research (2010) (0)
- Dried Feces Spots as an Alternative DNA Source: Detection of K-ras Mutations in Colorectal Cancer Screening (2001) (0)
- Erratum to: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma (2013) (0)
- Abstract 1222: p53 downregulates CRKL proto-oncogene protein through miR-200 family (2015) (0)
- Isolation andMappingof68RFLPMarkers on Human Chromosome6 (1992) (0)
- Targeted exome sequencing of cancer-related genes for somatic mutations and copy number variations in human cancer using the semiconductor sequencer (2016) (0)
- Reply: CIITA methylation and decreased levels of HLA-DR in tumour progression (2004) (0)
- Abstract 2523: Targeted exome sequencing profiles genetic alterations in oral squamous cell carcinoma from Japanese patients (2019) (0)
- [Isolation of target genes for a transcription factor using a Saccharomyces cerevisiae based screen]. (1997) (0)
- 282 Giant café-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi in a patient with mosaic neurofibromatosis type 1 caused by biallelic NF1 microdeletions (2019) (0)
- Abstract 1938: The identification of p53 target genes and noncoding RNAs through the combined analysis of RNA-seq and ChIP-seq data (2016) (0)
- Relapse and non-relapse prediction using a sensitive circulating tumor DNA assay during colorectal cancer postoperative surveillance (2022) (0)
- Abstract 4650: Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma (2017) (0)
- Abstract 5027: Exome sequencing of cancer-related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs (2017) (0)
- Therapeutic response monitoring using digital PCR for patient-specific circulating tumor DNA identified by an esophageal squamous cell carcinoma-specific sequencing panel. (2018) (0)
- MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway (2023) (0)
- Chromatin , Gene , and RNA Regulation AKR 1 B 10 , a Transcriptional Target of p 53 , Is Downregulated in Colorectal Cancers Associated with Poor Prognosis (2013) (0)
- Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes (2012) (0)
- Methylation in Colorectal Cancer Is Associated with CpG Island Translocation Gene 4 B-Cell and MicroRNA-34 b / c Epigenetic Silencing of Updated (2008) (0)
- Abstract 387: Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing (2017) (0)
- Abstract 139: Interaction between monocytes and bone marrow microenvironment in pathogenesis of multiple myeloma (2014) (0)
- Abstract 2284: Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR (2019) (0)
- Fledglings in p53 signaling network. (2017) (0)
- Prospective observational study of monitoring gene alterations in plasma cell-free DNA using droplet digital PCR system during anti-EGFR antibody treatment in patients with RAS wild-type advanced colorectal cancer. (2023) (0)
- UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells (2019) (0)
- K-ras/Ras effector alterations in colorectal cancers (2004) (0)
- Abstract 595: Single adenovirus-mediated simultaneous expression of p53 and the artificial microRNAs targeting anti-apoptotic p53 target genes (2010) (0)
- Gastric mucosal washing DNA -A new detection system as a molecular marker for gastric cancer- (2007) (0)
- Amplicon-based whole exome sequencing in oral squamous cell carcinoma from Japanese patients (2019) (0)
- Identification of a specific target sequence for p53 family in the Jagged2 gene (2005) (0)
- Identification of the Interleukin 4 Receptor (cid:1) Gene as a Direct Target for p73 (2003) (0)
- Abstract 3474: The effect of forced expression of k-ras mutation on gastrointestinal cancer cells and IGF-IR targeting therapy (2015) (0)
- Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma (2012) (0)
- ASSIGNMENT OF 54 COSMID CLONES TO 5 REGIONS OF CHROMOSOME-10 (1993) (0)
- Correction (2007) (0)
- 2P026 Direct observation of the multiple sliding modes of a tumor suppressor p53(01B. Protein: Structure & Function,Poster) (2013) (0)
- Allelotype Study of Primary Hepatocellular Carcinoma1 (2006) (0)
- Functional analysis of checkpoint ligase CHFR under mitotic stress (2005) (0)
- Abstract 1171: Identification of p53 target genes by ChIP-Seq and transcriptome analysis combined with genome-wide p53-binding motif analysisin silico (2012) (0)
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What Schools Are Affiliated With Takashi Tokino?
Takashi Tokino is affiliated with the following schools:
