Takeru Higuchi

Takeru Higuchi's AcademicInfluence.com Rankings

Takeru Higuchi

Chemistry

#805

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Organic Chemistry

#66

Historical Rank

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Chemistry

Why Is Takeru Higuchi Influential?

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According to Wikipedia, Takeru Higuchi was an American chemist who was widely known as "the father of physical pharmacy". He invented the time-release medication capsule, which would release medicine slowly into the bloodstream.

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Takeru Higuchi's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. (1963) (4569)
Phase solubility techniques (1965) (2641)
Rate of release of medicaments from ointment bases containing drugs in suspension. (1961) (1740)
DISSOLUTION BEHAVIOR OF CRYSTALLINE SOLVATED AND NONSOLVATED FORMS OF SOME PHARMACEUTICALS. (1963) (356)
Naphthalene-2,3-dicarboxyaldehyde/cyanide ion: a rationally designed fluorogenic reagent for primary amines (1987) (309)
Solubility behavior of organic compounds (1990) (212)
Enhancement of percutaneous absorption by the use of volatile: nonvolatile systems as vehicles. (1969) (156)
Theoretical analysis of diffusional movement through heterogeneous barriers (1960) (142)
Pro-drugs as Novel Drug Delivery Systems (1975) (134)
N-substituted 1-cyanobenz[f]isoindole: evaluation of fluorescence efficiencies of a new fluorogenic label for primary amines and amino acids. (1987) (121)
Binding specificity between small organic solutes in aqueous solution: classification of some solutes into two groups according to binding tendencies. (1970) (118)
RATES OF HYDROLYSIS OF CARBAMATE AND CARBONATE ESTERS IN ALKALINE SOLUTION. (1963) (110)
Polymorphism and drug availability. Solubility relationships in the methylprednisolone system. (1963) (108)
Multiple intermediates generate fluorophore-derived light in the oxalate/peroxide chemiluminescence system (1986) (96)
The physics of tablet compression. IV. Relationship of ejection, and upper and lower punch forces during compressional process: application of measurements to comparison of tablet lubricants. (1954) (90)
Thermodynamic group contributions from ion pair extraction equilibriums for use in the prediction of partition coefficients. Correlation of surface area with group contributions (1973) (86)
Quantitative analytical method for determination of drugs dispersed in polymers using differential scanning calorimetry. (1974) (84)
Enhancement of solubility of drug salts by hydrophilic counterions: properties of organic salts of an antimalarial drug. (1976) (80)
Enhanced rectal absorption of insulin and heparin in rats in the presence of non‐surfactant adjuvants (1981) (78)
The physics of tablet compression. II. The influence of degree of compression on properties of tablets. (1953) (78)
Effect of particle size and food on gastric residence time of non‐disintegrating solids in beagle dogs (1986) (74)
Enhancement of rectal absorption of insulin using salicylates in dogs (1983) (74)
The physics of tablet compression. IX. Fundamental aspects of tablet lubrication. (1956) (74)
Thermodynamic analysis of structure-activity relationships of drugs. Prediction of optimal structure. (1970) (71)
PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE. (1964) (67)
Improved delivery through biological membranes. 4. Prodrugs of L-dopa. (1977) (67)
Micellar acceleration of organophosphate hydrolysis by hydroximinomethylpyridinium type surfactants (1978) (66)
Clinical analysis of tamoxifen, an anti-neoplastic agent, in plasma. (1978) (66)
The physics of tablet compression. V. Studies on aspirin, lactose, lactose-aspirin, and sulfadiazine tablets. (1954) (66)
Delivery of a quaternary pyridinium salt across the blood-brain barrier by its dihydropyridine derivative (1975) (64)
Enhanced Intestinal Absorption of Insulin in Rats in the Presence of Sodium 5-Methoxysalicylate (1981) (63)
Solubility determination of barely aqueous-soluble organic solids. (1979) (63)
Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule. (1978) (59)
Plastic electrodes specific for organic ions (1970) (58)
Ion pair extraction of pharmaceutical amines. Role of dipolar solvating agents in extraction of dextromethorphan. (1967) (58)
Drug delivery from catalysed erodible polymeric matrices of poly(ortho ester)s. (1984) (54)
Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride. (1976) (53)
Calculation of stability constants of hydrogen-bonded complexes from proton magnetic resonance data. Interactions of phenol with dimethylacetamide and various ketones. Solvent effect (1967) (51)
Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form. (1976) (49)
Reversible association of caffeine and of some caffeine homologs in aqueous solution. (1957) (49)
The physics of tablet compression. VII. Determination of energy expenditure in the tablet compression process. (1955) (48)
Thermodynamic group contributions for hydroxyl, amino, and methylene groups. (1978) (46)
Investigation of drug release from solids. II. Theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids. (1958) (46)
Prodrugs of 6-thiopurines: enhanced delivery through the skin. (1983) (45)
Study of possible complex formation between macromolecules and certain pharmaceuticals. I. Polyvinylpyrrolidone with sulfathiazole, procaine hydrochloride, sodium salicylate, benzyl penicillin, chloramphenicol, mandelic acid, caffeine, theophylline, and cortisone. (1954) (44)
Effects of salicylate on rectal absorption of theophylline. (1981) (43)
Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants. (1982) (43)
N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems. (1976) (41)
Suggested thermodynamic standard state for comparing drug molecules in structure-activity studies. (1972) (40)
Investigation of some complexes formed in solution by caffeine. II. Benzoic acid and benzoate ion. (1953) (39)
Kinetics of thiamine hydrolysis. (1962) (39)
Determination of dopamine, norepinephrine, and related trace amines by prechromatographic derivatization with naphthalene-2,3-dicarboxaldehyde. (1989) (39)
Chromatographic Separation and Determination of Dicarboxylic Acids C4 to C10 (1952) (38)
Solubility of polar organic solutes in nonaqueous systems: role of specific interactions. (1980) (38)
RATE OF ANAEROBIC DEGRADATION OF ASCORBIC ACID IN AQUEOUS SOLUTION. (1963) (38)
Gas Chromatographic Separation of Some Permanent Gases on Silica Gel at Reduced Temperatures (1957) (38)
Effect of salicylate on the rectal absorption of lidocaine, levodopa, and cefmetazole in rats. (1982) (38)
Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits. (1983) (38)
Enhanced rectal absorption of cefmetazole and cefoxitin in the presence of epinephrine metabolites in rats and a high-performance liquid chromatographic assay for cephamycin antibiotics. (1984) (37)
Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter. (1982) (36)
Rational development of a soluble prodrug of a cytotoxic nucleoside: preparation and properties of arabinosyladenine 5'-formate. (1975) (36)
Enhancement of rectal absorption of drugs by adjuvants. (1980) (35)
The physics of tablet compression. XI. Determination of porosity of tablet granulations. (1956) (35)
Kinetics and Mechanism of Formation of Sulfonate from Epinephrine and Bisulfite (1960) (35)
Study of possible complex formation between macromolecules and certain pharmaceuticals. II. Polyvinylpyrrolidone with p-aminobenzoic acid, aminopyrine, benzoic acid, salicylic acid, p-hydroxybenzoic acid, m-hydroxybenzoic acid, citric acid, and phenobarbital. (1954) (35)
Unsaturated cyclic ureas as new non-toxic biodegradable transdermal penetration enhancers. II. Evaluation study (1989) (34)
Possible complex formation between macromolecules and certain pharmaceuticals. X. The interaction of some phenolic compounds with polyethylene glycols, polypropylene glycols, and polyvinylpyrrolidone. (1956) (34)
Investigation of drug release from solids. I. Some factors influencing the dissolution rate. (1955) (33)
Comparison of the effects of sodium salicylate, disodium ethylenediaminetetraacetic acid and polyoxyethylene−23−lauryl ether as adjuvants for the rectal absorption of sodium cefoxitin (1985) (33)
N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2-oxazolidinones. (1976) (33)
Direct potentiometric and titrimetric determination of methadone in urine with plastic electrodes selectiive for hydrophobic cations. (1978) (33)
A Thermometric Method for Thermodynamics Studies and Molecular Weight Determinations in Solutions (1959) (32)
Oxidation of Thioethers by Iodine to Sulfoxides. Catalytic Role of Certain Inorganic Nucleophiles1 (1966) (32)
Study of possible complex formation between macromolecules and certain pharmaceuticals. III. Interaction of polyethylene glycols with several organic acids. (1954) (32)
Caffeine complexes with low water solubility: synthesis and dissolution rates of 1:1 and 1:2 caffeine-gentisic acid complexes. (1973) (31)
Vapor pressure studies of the self-association of alcohols in isooctane. 2. The effect of chain branching (1978) (31)
Vapor pressure studies of self-association of alcohols in isooctane. I. the effect of chain length (1978) (30)
Improved delivery of methoxsalen. (1979) (30)
N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives. (1976) (30)
Facilitated Reversible Formation of Amides from Carboxylic Acids in Aqueous Solutions. Intermediate Production of Acid Anhydride (1963) (30)
The physics of tablet compression. X. Mechanism of action and evaluation of tablet lubricants. (1960) (29)
Lymphatic uptake of water‐soluble drugs after rectal administration (1982) (29)
Calorimetric study of the self-association of primary alcohols in isooctane (1975) (29)
Long-acting contraceptive agents: Design of the who chemical synthesis programme (1983) (29)
Photometric Determination of Indicator End Points (1956) (29)
Molecular interactions and solubility of polar nonelectrolytes in nonpolar solvents. (1971) (29)
The physics of tablet compression. I. A preliminary report. (1952) (29)
Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride. (1976) (29)
Enhanced bioavailability of insulin after rectal administration with enamine as adjuvant in depancreatized dogs (1985) (29)
Solid state stability of some crystalline vitamin A compounds. (1962) (28)
Mechanism of chlorination of cresol by chloramine-T. Mediation by dichloramine-T (1967) (28)
A general method for the chromatographic analysis of mono-, di-, and triglycerides and the mono- and diesters of ethylene glycol and polyethylene glycol (1960) (28)
Mechanism and thermodynamics of chlorine transfer among organochlorinating agents. Part II. Reversible disproportionation of chloramine-T (1967) (28)
The intramolecular facilitated hydrolytic rates of methyl-substituted succinanilic acids. (1966) (27)
Unsaturated cyclic ureas as new nontoxic biodegradable transdermal penetration enhancers I: Synthesis. (1988) (27)
Esters of hydantoic acids as prodrugs of hydantoins. (1973) (26)
Kinetic investigation of reversible reaction between methionine and iodine. Improved iodometric determination of methionine. (1967) (26)
Electrometric Titration of Alcohols Using Lithium Aluminum Hydride (1950) (26)
Effect of enamine derivatives on the rectal absorption of insulin in dogs and rabbits (1983) (26)
Complexation of organic substances in aqueous solution by hydroxyaromatic acids and their salts. Relative contributions of several factors to the overall effect. (1961) (25)
The solubility and complexing properties of oxytetracycline and tetracycline. III. Interactions in aqueous solution with model compounds, biochemicals, metals, chelates, and hexametaphosphate. (1959) (25)
Investigation of some complexes formed in solution by caffeine. III. Interactions between caffeine and aspirin, p-hydroxybenzoic acid, m-hydroxybenzoic acid, salicylic acid, salicylate ion, and butyl paraben. (1953) (25)
A study of permeability to water vapor of fats, waxes, and other enteric coating materials. (1959) (25)
Phase Solubility Analysis (1970) (25)
Rapidly Dissolving Forms of Digoxin: Hydroquinone Complex (1974) (24)
Solvency and hydrogen bonding interactions in nonaqueous systems. (1969) (24)
IMPROVED DELIVERY THROUGH BIOLOGICAL MEMBRANES. 4. PRODRUGS OF L-DOPA (1978) (23)
High-performance liquid chromatographic analysis of dianhydrogalactitol in plasma by derivatization with sodium diethyldithiocarbamate. (1977) (23)
Enhanced small intestinal absorption of cefmetazole and cefoxitin in rats in the presence of non‐surfactant adjuvants (1983) (23)
Some equilibrium and kinetic aspects of water sorption in poly(ortho ester) s (1985) (23)
Acid anhydride-free acid equilibria in water in some substituted succinic acid systems and their interaction with aniline (1967) (23)
Solubilization and stabilization of the cytotoxic agent coralyne. (1975) (23)
The kinetics of the hydrolysis of procaine. (1950) (23)
Kinetics of degradation in solution of epinephrine by molecular oxygen. (1962) (23)
Kinetics of the acid-catalyzed closure of hydantoic acids. Effect of 2-aryl and 2-alkyl substituents (1973) (22)
Oxidation of thioethers to sulfoxides by iodine. II. Catalytic role of some carboxylic acid anions (1968) (22)
GLC determination of whole blood antimalarial concentrations. (1979) (22)
Ion-Pair Extraction of Pharmaceutical Amines II: Extraction Profile of Chlorpheniramine (1966) (22)
Influence of self-association on the solubility of phenol in isooctane and cyclohexane (1979) (22)
Specificity of esterases and structure of prodrug esters: reactivity of various acylated acetaminophen compounds and acetylaminobenzoated compounds. (1988) (22)
N-Halo derivatives IV: Synthesis of low chlorine potential soft N-chloramine systems. (1976) (21)
Inhibition of hydrolysis of esters in solution by formation of complexes. I. Stabilization of benzocaine with caffeine. (1955) (21)
COMPLEXATION OF ORGANIC SUBSTANCES IN AQUEOUS SOLUTION BY HYDROXYAROMATIC ACIDS AND THEIR SALTS. II. INFLUENCE OF HALOGEN, NITRO, AND OTHER SUBSTITUENTS AND CORRELATION OF BINDING TENDENCIES TOWARD PREDNISOLONE, THEOPHYLLINE, AND PHENACETIN. (1961) (21)
Investigation and Development of Protective Ointments IV.: The influence of active fillers on the permeability of semisolids (1960) (21)
Conductometric Titration of Sulfuric and Hydrochloric Acids and Their Mixtures in Anhydrous Acetic Acid (1955) (21)
Amino Acid Esters of Phenols as Prodrugs: Synthesis and Stability of Glycine, β-Aspartic acid, and α-Aspartic Acid Esters of p-Acetamidophenol (1981) (21)
Circulation Apparatus for Photometric Titrations (1959) (20)
Solubilizing action of caffeine on benzoic acid. (1952) (19)
Behavior of Acid-Base Indicators in Acetic Acid System (1956) (19)
N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs II: possible prodrugs of allopurinol, glutethimide, and phenobarbital. (1981) (19)
Chemical equilibria in solutions of bisulfite salts. (1974) (19)
Investigation of some complexes formed in solution by caffeine. V. Interactions between caffeine and p-aminobenzoic acid, m-hydroxybenzoic acid, picric acid, o-phthalic acid, suberic acid, and valeric acid. (1953) (19)
Titration of Very Weak Acids with Lithium Aluminum Amides (1952) (18)
Role of solvating agents in promoting ion pair extraction (1971) (18)
Effect of aprotinin on the rectal delivery of insulin (1983) (18)
FACILITATED REVERSIBLE FORMATION OF AMIDES FROM CARBOXYLIC ACIDS IN AQUEOUS SOLUTIONS. III. REACTION OF CITRIC ACID WITH AROMATIC AMINES. (1964) (18)
Investigation of complexes formed in solution by caffeine. VI. Comparison of complexing behaviors of methylated xanthines with p-aminobenzoic acid, salicylic acid, acetylsalicylic acid, and p-hydroxybenzoic acid. (1954) (18)
Letter: Amino acid esters of phenolic drugs as potentially useful prodrugs. (1975) (17)
Complexation in formulation of parenteral solutions: solubilization of the cytotoxic agent hexamethylmelamine by complexation with gentisic acid species. (1975) (17)
Photometric Indicator Titration of Weak Bases in Acetic Acid. Modified Type II Plot (1960) (17)
The kinetics of degradation of chloramphenicol in solution. II. Over-all disappearance rate from buffered solutions. (1954) (17)
Effects of solute-solvent complexation reactions on dissolution kinetics: testing of a model by using a concentration jump technique. (1972) (17)
Mechanism and thermodynamics of chlorine transfer among organohalogenating agents. Part IV. Chlorine potentials and rates of exchange (1969) (17)
Behavior of some inorganic anions as bases in glacial acetic acid. (1951) (17)
Prediction of chlorine potentials of N-chlorinated organic molecules (1969) (16)
Influence of electrolytes, pH, and alcohol concentration on the solubilities of acidic drugs. (1953) (16)
Interaction of di- and tricarboxylic acids with glutaric anhydride in aqueous solution. (1966) (16)
Electrical charge conduction mechanism of a polymer membrane electrode selective for hydrophobic cations (1982) (16)
Acylation through a Sulfonium Ion Intermediate. Coupled Conversion of a Carboxylic Acid to an Acid Anhydride during Oxidation of a Thioether to a Sulfoxide1 (1966) (16)
Inhibition of hydrolysis of esters in solution by formation of complexes. II. Stabilization of procaine with caffeine. (1956) (16)
Effect of solvent composition on association between small organic species. (1970) (16)
Hydroxylammonium Acetate as Carbonyl Reagent (1956) (16)
RATE STUDIES ON THE ANAEROBIC DEGRADATION OF ASCORBIC ACID. 3. RATE OF FORMATION OF FURFURAL. (1965) (16)
Evaluation of Amides and Other Very Weak Bases in Acetic Acid. (1962) (16)
Degradation of epinephrine induced by bisulfite. (1958) (16)
REVERSIBLE FORMATION OF AMIDES FROM FREE CARBOXYLIC ACID AND AMINE IN AQUEOUS SOLUTION. A CASE OF NEIGHBORING GROUP FACILITATION1 (1961) (15)
Quantitative analysis of microgram quantities of pilocarpine in aqueous solution. (1971) (15)
Extrapolation Plot for Photometric Titration of Weak Bases in Aqueous and Nonaqueous Systems (1957) (15)
Controlled delivery of theophylline: chemistry of 7-acyl- and 7,7'-acylditheophylline derivates. (1978) (15)
Rearrangement of chloramphenicol-3-monosuccinate. (1970) (15)
Enhancement of rectal absorption of water-soluble antibiotics in dogs (1984) (15)
Mechanism and kinetics of ion pair extraction. Rate of extraction of dextromethorphanium ion (1968) (15)
The kinetics of degradation of chloramphenicol in solution. III. The nature, specific hydrogen ion catalysis, and temperature dependencies of the degradative reactions. (1954) (15)
Synthesis, isolation, and some chemistry of citric acid anhydride. (1969) (15)
Aminolysis of acid anhydrides in water. I. Rate acceleration of hydrophobic bonding in reactions between small molecules (1972) (14)
Chromatographic analysis of mixtures of mono-, di-, and tristearin containing mineral oil (1957) (14)
Potentiometric determination of oxygen using the dropping mercury electrode. (1948) (14)
Determination of thermodynamics of the methylene group in solutions of drug molecules. (1972) (14)
Design of chemical structure for optimal dermal delivery. (1978) (14)
The synergistic effects of concurrent administration to rats of EDTA and sodium salicylate on the rectal absorption of sodium cefoxitin and the effects of inhibitors (1987) (14)
Effect of rectal suppository formulation on the release of insulin and on the glucose plasma levels in dogs (1985) (14)
An automated method for continuously monitoring diffusion cells in skin penetration studies (1989) (13)
Spectropolarimetric and circular dichroism methods for determining the activity of penicillin. (1971) (13)
Rate studies on the hydrolysis of niacinamide. (1962) (13)
Kinetics and mechanism of hydrolysis of labile quaternary ammonium derivatives of tertiary amines. (1982) (13)
Analysis of hydrophobic amine antimalarials in biological fluids with the plastic ion-selective electrode. (1979) (13)
Behaviors of Several Compounds as Indicators in Lithium Aluminum Hydride Titration of Functional Groups1 (1951) (13)
An Improved Synthesis of 1-Alkyl-4-imidazolin-2-ones (1987) (13)
Determination of molecular binding in aqueous solution from optical activity measurements. Interaction of tryptophan with alkylxanthines. (1968) (12)
Titration of Functional Groups with Lithium Aluminum Hydride (1950) (12)
Esterase activity in snake skin (1988) (12)
Binding of bile acids to cholestyramine at gastric pH conditions. (1975) (12)
Determination of fluorescent cyanobenz[f]isoindole derivatives of dopamine and norepinephrine using high performance liquid chromatography with chemiluminescence detection. (1990) (12)
Reactivity of bisulfite with a number of pharmaceuticals. (1959) (12)
Enhanced rectal absorption of sodium ampicillin by N-acyl derivatives of collagen peptide in rabbits and rats. (1985) (12)
Deuterium isotope effects on degradation of hydrocortisone in aqueous solution. (1972) (12)
The kinetics of degradation of chloramphenicol in solution. I. A study of the rate of formation of chloride ion in aqueous media. (1953) (12)
Determination of aspartic acid, phenylalanine, and aspartylphenylalanine in aspartame-containing samples using a precolumn derivatization HPLC method (1990) (11)
N-chlorosaccharin as a possible chlorinating reagent: structure, chlorine potential, and stability in water and organic solvents. (1970) (11)
Investigation and development of protective ointments. I. Development of a method for measuring permeation of mechanical barriers. (1957) (11)
Hydrolysis of some poly(ortho-ester)s in homogeneous solutions. (1984) (11)
Ion-pair extraction of pharmaceutical amines. IV. Influence of anion on enthalpic, entropic, and free energy changes resulting from phase transfer. (1969) (11)
Rates of hydrolysis of N-chlorinated molecules. (1972) (10)
Potentiometric Studies on Sodium Acetate–Sodium Perchlorate Systems in Acetic Acid (1954) (10)
The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole. (1984) (10)
Kinetics of nitrous acid induced reserpine fluorescence. (1966) (10)
Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs. (1984) (10)
Rate Studies on the Anaerobic Degradation of Ascorbic Acid IV: Catalytic Effect of Metal Ions (1966) (10)
Interaction studies of cationic drugs with anionic polyelectrolytes. I. Sodium carboxymethylcellulose. (1956) (10)
Asymmetric Oxidation of Thioethers to Sulfoxides. Configurational Specificity Induced by Optically Active Organic Catalysts1 (1966) (10)
Gas-chromatographic analysis for 1,2:5,6-dianhydrogalactitol, an anti-neoplastic agent, in plasma. (1976) (10)
PERCHLORATE FORMATION CONSTANTS FOR SOME WEAK BASES IN ACETIC ACID (1960) (9)
Effect of suppository shape on the systemic availability of rectally administered insulin and sodium salicylate (1986) (9)
Hydrolytic behavior of N-acyl phthalimides. (1973) (9)
Unexpectedly rapid esterification of nitrite applied to the determination of nitrite in water. (1978) (9)
A kinetic study of acid-catalyzed racemization of epinephrine. (1958) (9)
Sabadilla alkaloids. III. Chromatographic separation of the water-soluble fraction; isolation of a new crystalline alkaloid, sabatine. (1951) (9)
Loss of hydrophobic amine from solution by adsorption onto container surfaces. (1979) (9)
Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine. (1977) (9)
Possible utilization of polyelectrolytes in enhancing drug absorption. (1954) (9)
Mechanism and thermodynamics of chlorine transfer among organochlorinating agents. Part III. Autocatalytic pathway between N-chloro-succinimide and chloramine-T (1968) (9)
Aminolysis of acid anhydrides in water. II. Nonlinear structure-reactivity relations in the aminolyses of phthalic and succinic anhydrides (1972) (9)
Reversible formation and hydrolysis of phthaloyl and succinyl monophosphates in aqueous solution. (1967) (9)
Intramolecular bifunctional facilitation in complex molecules. Combined nucleophilic and general acid participation in hydrolysis of hexchlorophene monosuccinate (1971) (8)
The physics of tablet compression. VI. Compressional behavior of phenacetin and methacetin granulations. (1954) (8)
Determination of stability constants from optical rotatory dispersion measurements. Camphor-phenol system in carbon tetrachloride. (1965) (8)
Programmed diffusional release rate from encapsulated cosolvent system. (1976) (8)
IMPROVED DELIVERY THROUGH BIOLOGICAL MEMBRANES. 1. SYNTHESIS AND PROPERTIES OF 1-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME, A PRO-DRUG OF N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE (1976) (8)
Formation of molecular complexes by some water-soluble amides. I. Interaction of several amides with p-hydroxybenzoic acid, salicylic acid, chloramphenicol, and phenol. (1956) (8)
Partial vapor pressures and solubilities of cyclic polar compounds iniso-octane solutions (1984) (8)
Acylation of ascorbic acid in water. (1975) (7)
Specific solvation effects on acylation of amines in solvents with low dielectric constants (1975) (7)
Study of Possible Complex Formation BetweenMacromolecules and Certain Pharmaceuticals IX: Formation of Iodine-Iodide Complexes with Polyethylene Glycol: Formation of Iodine-Iodi de Complexes with Polyethylene Glycol (1955) (7)
Formation of molecular complexes by diketobenzodiazines and their methylated derivatives with phenol and dihydroxybenzenes in aqueous solutions. (1961) (7)
Determination of epinephrine in the presence of degradation products. (1959) (7)
A preliminary Pharmacokinetic study of dianhydrogalactitol (NSC-132313) disposition in the dog. (1977) (7)
Intestinal absorption of sodium cefoxitin in rats: effect of formulation (1986) (7)
Solvolytic reactions of cyclic anhydrides in anhydrous acetic acid. (1975) (7)
Arabic acid and its salts. I. The preparation of arabic acid and sodium arabate powder. (1951) (6)
Graphical analysis of photometric indicator titration data (1961) (6)
Investigation of human skin lipids. II. (1958) (6)
Diffusion of phenol in the presence of a complexing agent, tetrahydrofuran. (1983) (6)
Complexes formed in solution by homologs of caffeine; interactions between p-hydroxybenzoic acid and ethyl, propyl, and butyl derivatives of theobromine, and theophylline. (1957) (6)
A note on the preparation of 1-(3,4-dihydroxyphenyl)-2-methylamino-ethane sulfonic acid from epinephrine. (1960) (6)
Hydrolysis and dissolution behavior of a prolonged-release prodrug of theophylline: 7,7'-succinylditheophylline. (1979) (6)
The Chemistry of a Novel 5,5-Diphenylhydantoin Pro-drug (1975) (6)
Erosion of poly(ortho ester) matrices in buffered aqueous solutions (1986) (6)
Hydrolytic behavior of some alkyl-substituted succinanils. (1966) (6)
Characterization of Racemic α-Hydroxy- and β-Hydroxysuccinanilic Acids (1968) (6)
Effect of molecular conformation on interaction of organic species in water. Benzamides and anisamides with theophylline and riboflavin. (1968) (6)
Application of lithium aluminum hydride titrimetric method to pharmaceutical compounds. (1950) (6)
Lymphatic transport of sodium cefoxitin in the presence of sodium 5‐methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein (1985) (6)
Interaction of acetic anhydride with di- and tri-carboxylic acids in aqueous solution. (1966) (6)
ArticlesInvestigation of Human Skin Lipids I (1958) (6)
Rate Studies On the Anaerobic Degradation of Ascorbic Acid III (1965) (5)
Complexes formed in aqueous solutions by sarcosine anhydride; interactions with organic acids, phenols, and aromatic alcohols. (1959) (5)
Inhibition of hydrolysis of esters in solution by formation of complexes. IV. Stabilization of benzocaine with 1-ethyltheobromine. (1957) (5)
Scientific EditionInhibition of Hydrolysis of Esters in Solution Formation of Complexes III.*: Stabilization of Tetracaine with Caffeine (1957) (5)
RATE OF ANHYDRIDE FORMATION IN TARTRATE BUFFER SYSTEM. NATURE OF REACTION PRODUCT WITH ANILINE. (1965) (5)
Effect of self-association of phenol on its transport across polyethylene film. (1980) (5)
Synthesis and isolation of citric acid anhydride. (1969) (5)
Catalysis of anhydride formation in aqueous solutions of dicarboxylic acids. (1966) (5)
Interaction studies of cationic drugs with anionic polyelectrolytes. II. Polyacrylic and styrene polymers. (1957) (4)
The Metabolic Disposition of a Novel 5,5-Diphenylhydantoin Pro-drug (1975) (4)
NMR evidence for self-association of teophylline in aqueous solution: a response. (1971) (4)
Effect of various compounds on the rate of thiamine hydrolysis. (1963) (4)
Investigation and development of protective ointments. II. Influence of partition coefficient and thickness. (1957) (4)
Formation of molecular complexes by some water-soluble amides. II. Effect of decreasing water solubility on degree of complex formation. (1956) (4)
Collisionally induced dissociation in the study of A-ring hydroxylated vitamin D type compounds. (1992) (4)
Determination of Tensile Strength of Natural Rubber and GR-S. Effect of Specimen Size (1949) (4)
Carbonation of aqueous solutions with acid anhydrides. Slow acidification in homogeneous systems. (1965) (4)
Pharmacy, pharmaceutics and modern drug delivery. (1976) (4)
Interaction of acetic anhydride with di- and tricarboxylic acids in aqueous solution. II. Acetic anhydride in malic, tartaric, and succinic acid buffers. (1968) (4)
The Preparation and Vapor Pressure of Bromopentachloroethane; the Vapor Pressures of Heptachloropropane and Dibromotetrachloroethane (1949) (3)
Importance of the Debye interaction in organic solutions: Henry's law constants for polar liquids in nonpolar solvents and vice versa (1986) (3)
Changes in Intestinal Mucosal Permeability Caused by Nonprotein Thiol Loss in Rats (1986) (3)
Kinetics of the degradation of isoamyl nitrite in ampuls. I. Nature of reaction products and influence of temperature, oxygen, alcohol, water, and acid on the overall rate. (1958) (3)
The lipid osmotic pump (1986) (3)
Pro-drugs as novel drug delivery systems : a symposium (1975) (3)
Study of possible complex formation between macromolecules and certain pharmaceuticals. IX. Formation of iodine-iodide complexes with polyethylene glycol. (1955) (3)
Preparation of some steroids in microcrystalline form by rapid freeze-sublimation technique. (1954) (3)
Melting and freezing behavior of methyl stearate. (1962) (3)
Separation and Analvsis of APC Combination bv d Partition Chromatography (1952) (3)
A pharmaceutical study of Jelene ointment base. (1951) (3)
Scientific EditionThe solubility and complexing properties of oxytetracycline and tetracycline II*: Interactions in nonaqueous solution (1957) (3)
A note on the water solubility of some N,N,-dialkylamides. (1957) (3)
Phase solubility of solid species formed by magnesium aluminate from aqueous solutions containing sulfate ions. (1963) (3)
Comparison of a microbiological and a chromatographic assay method for chloramphenicol. (1954) (3)
Preparation of Hydroxybenzylsulfonic Acids (1961) (3)
Rectal absorption and lymphatic uptake of Ara-C in rats (1986) (2)
Electrometric titration of volatile oils and volatile oil isolates using lithium aluminum hydride. (1950) (2)
N-HALO DERIVATIVES. III- STABILIZATION OF NITROGEN-CHLORINE BOND IN N-CHLOROAMINO ACID DERIVATIVES (1976) (2)
Simultaneous self-association and diffusion of phenol in isooctane. (1982) (2)
Investigation of human skin lipids. I. (1958) (2)
Arabic acid and its salts. II. The effect of cations on the viscosity of arabic acid solutions. (1951) (2)
Covalent addition of N-chlorosaccharin to cyclohexene. (1970) (2)
Sabadilla alkaloids; alkaloidal components of the petroleum ether extract. (1949) (2)
Spray-drying of insoluble weakly acidic pharmaceuticals through their ammonium salts. (1952) (2)
Chromatographic separation and determination of mixtures of p-hydroxybenzoate esters. (1952) (2)
Kinetics of reaction between molecular oxygen and 2, 3-dimercapto-1-propanol in aqueous solution. (1962) (2)
Inhibition of hydrolysis of esters in solution by formation of complexes. III. Stabilization of tetracaine with caffeine. (1957) (2)
Bisulfite reduction of p-nitrobenzyl alcohol. (1962) (2)
Amino acid esters of phenols as prodrugs: synthesis and stability of glycine, beta-aspartic acid, and alpha-aspartic acid esters of p-acetamidophenol. (1981) (2)
MUTUAL INDEPENDENCE OF RELEASE RATES OF STEROIDS FROM A TOPICAL VEHICLE. IMPLICATIONS FOR POTENTIALLY OPTIMAL FORMULATIONS. (1965) (1)
The solubility and complexing properties of oxytetracycline. I. Interaction in aqueous solution. (1957) (1)
ESTERS OF HYDANTOIC ACIDS AS PRODRUGS OF HYDANTOINS (1973) (1)
CONTROLLED DELIVERY OF THEOPHYLLINE: CHEMISTRY OF 7-ACYL- AND 7,7′-ACYLDITHEOPHYLLINE DERIVATIVES (1979) (1)
PRODRUGS, SAFER AND MORE EFFECTIVE (1975) (1)
A dilatometric study of melting behaviors of some fats, waxes, and related substances of pharmaceutical importance. I. Polyethylene glycols, spermaceti, cetyl alcohol, petrolatum, white wax, and theobroma oil. (1957) (1)
an Anti-NeoplasticAgent,in Plasma (1976) (1)
Equilibria and thermodynamics (1991) (1)
Formation of complexes by N,N'-dimethyl-diketobenzodiazines in nonaqueous solutions. (1959) (1)
Effects of temperature and pressure on short term storage of platelets (1975) (1)
Heat sterilization of thermally labile solutions. (1950) (1)
The complexing tendencies of cyanocobalamin with inorganic compounds. Heteromolyhdates and heavy metal chlorides. (1960) (1)
Physical chemical properties and ultraviolet spectral characteristics of amyl nitrite. (1956) (1)
Acylation of phenol by cyclic and acyclic anhydrides in anhydrous acetic acid. (1975) (1)
Carboxylate-facilitated acetylation of hydroxy acids in aqueous solution (1969) (1)
The liquid-liquid counter current separation of a menthol-menthyl acetate mixture. (1953) (1)
PRODRUGS OF 6-THIOPURINES: ENHANCED DELIVERY THROUGH THE SKIN (1983) (1)
Investigation and Development of Protective Ointments III*: Adsorption characteristics of sarin from solutions (1960) (1)
Drug stability and kinetics (1991) (1)
Kinetics of copper catalyzed oxidation of 2, 3-dimercapto-1-propanol by molecular oxygen. (1962) (1)
Osmotic pump for lipids. (1986) (0)
Drug-releasing system using waermehaertender gels. (1984) (0)
Separation and analysis of APC combination by partition chromatography. (1952) (0)
N-Halo Derivatives. Part 6. Microbiological and Chemical Evaluations of 3-Chloro-2-oxazolidinones. (1977) (0)
Letter: Rapidly dissolving forms of digoxin: hydroquinone complex. (1974) (0)
Laegemiddelformuleringer on the basis of polyoxaminer (1984) (0)
HYDROLYTIC BEHAVIOR OF N-ACYL PHTHALIMIDES (1973) (0)
Dilatometric determination of relatively pure systems. (1961) (0)
REACTIONS OF IODOCARBENOID WITH ZINC. III. RING-EXPANSION OF BENZENE WITH IODOFORM AND DIALKYLZINCS OR ALKYLZINC IODIDES (1976) (0)
サリチル酸ナトリウム,エチレンジアミン四酢酸ニナトリウム,及びポリオキシエチレン(23)ラウリルエーテルのセフォキシチンナトリウム直腸吸収促進効果の比較(発表論文抄録(1985年)) (1986) (0)
Specificity of Esterases and Effect of Structure of Prodrug Esters of Acylated Acetaminophen on Hydrolytic Reactivity (1984) (0)
N-HALO DERIVATIVES IV. SYNTHESIS OF LOW CHLORINE POTENTIAL SOFT N-CHLORAMINE SYSTEMS (1977) (0)
Container for osmotic delivery of a substance or a composition (1983) (0)
Dynamic friction of some film coatings on rat stomach mucosa in vitro — effect of pH (1986) (0)
Kinetics of Degradation of Amyl Nitrite Ampule II. Stabilization. | Article Information | J-GLOBAL (1958) (0)
エピネフリン代謝物によるセフメタゾール,セホキシチンのラット直腸吸収促進及びセファマイシン系抗生物質の高速液体クロマトグラフィーによる血中濃度の測定(発表論文抄録(1984年),福山大学開学10周年記念号) (1985) (0)
A process for preparing a rectally administrable suppository containing an adjuvant (1980) (0)
Letter to the editorNew electrode system sensitive to very small gaseous samples (1960) (0)
Dispositif osmotique pour libérer une substance active (1983) (0)
Kinetics of degradation of amyl nitrite ampuls. II. Stabilization. (1958) (0)
MOLECULAR CATALYSIS AND INTERACTIONS IN AQUEOUS SOLUTIONS (1964) (0)
Unsaturated Cyclic Ureas as New Nontoxic Biodegradable Transdermal Penetration Enhancers. Part 1. Synthesis. (1989) (0)
Biodegradable eyes use for administration of a medicinal (1972) (0)
Theophylline derivatives, process for their preparation and drug (1975) (0)
STUDY OF REACTIONS BETWEEN ORGANIC HALOGENATING AGENTS AND TERTIARY AMINES. (1961) (0)
Multiple Intermediates Generate Fluorophore-Derived Light in the Oxalate/Peroxide Chemiluminescence System. (1987) (0)
Particle size: Measurement, interpretation, and application: By Riyad R. Ivani and Clayton F. Callis. Wiley, New York, 1963. viii + 165 pp. $7.50 (1964) (0)
ocular device for the administration of a (1973) (0)
The Work of Takeru Higuchi : a memorial tribute (1992) (0)
REACTIONS BETWEEN TERTIARY AMINES AND ORGANOHALOGENATING AGENTS. (1966) (0)
An Improved Synthesis of 1-Alkyl-4-imidazolin-2-ones. (1988) (0)
STUDY OF REACTIONS BETWEEN TERTIARY AMINES AND ORGANOHALOGENATING AGENTS. (1962) (0)
OF ACYLATED ACETAMINOPHEN ON HYDROLYTIC REACTIVITY (1984) (0)
Kinetics of Degradation of Amy1 Nitrite Ampuls II.**School of Phamacy, University of Wisconsin, Madison. This study was supported in part by a contract with the Armed Service Medical Procurement Agency, Brooklyn. N. Y. (1958) (0)
A container for osmotic delivery of a substance or substance mixture (1983) (0)
A method for determining primaeraminen using aromatic dialdehydes. (1986) (0)
Characterization of racemic alpha-hydroxy- and beta-hydroxysuccinanilic acids. (1968) (0)
Osmotic device of distribution (1973) (0)
REACTIONS BETWEEN SECONDARY AMINES AND ORGANO-HALOGENATING AGENTS. (1964) (0)
Preparation of hydroxybenzyl-sulfonic acids. (1961) (0)

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Takeru Higuchi is affiliated with the following schools:

University of Akron
University of Kansas