Takeshi Okanoue
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Computer Science
Takeshi Okanoue's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Takeshi Okanoue's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues (2006) (1198)
- The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation (2007) (573)
- A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. (2020) (504)
- Side effects of high-dose interferon therapy for chronic hepatitis C. (1996) (436)
- Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan (2001) (424)
- A case‐control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C (2001) (395)
- Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. (2011) (366)
- Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas (2005) (323)
- Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population (2011) (288)
- Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan. (2012) (259)
- Management of Hepatocellular Carcinoma in Japan: Consensus-Based Clinical Practice Manual Proposed by the Japan Society of Hepatology (2007) (256)
- Interferon therapy lowers the rate of progression to hepatocellular carcinoma in chronic hepatitis C but not significantly in an advanced stage: a retrospective study in 1148 patients. Viral Hepatitis Therapy Study Group. (1999) (241)
- Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. (2008) (228)
- Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection (2006) (221)
- Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials. (2020) (214)
- Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease (2012) (209)
- Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. (2003) (204)
- Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B: A multicenter retrospective study of 2795 patients. (2005) (193)
- Expression of IFN-inducible protein-10 in chronic hepatitis. (1997) (188)
- A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease (2011) (185)
- Coordinated Ciliary Beating Requires Odf2-Mediated Polarization of Basal Bodies via Basal Feet (2012) (184)
- Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes. (2001) (179)
- Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease (2010) (169)
- A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. (2001) (168)
- PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats (2004) (166)
- Noninvasive Tests Accurately Identify Advanced Fibrosis due to NASH: Baseline Data From the STELLAR Trials (2019) (158)
- Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. (1999) (155)
- Simeprevir with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1 patients in Japan: CONCERTO-1, a phase III trial. (2014) (145)
- Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection. (2000) (144)
- Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy (2004) (140)
- Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease (2009) (140)
- A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update (2018) (138)
- Increase of chemokine interferon‐inducible protein‐10 (IP‐10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes (2001) (135)
- Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study (2014) (134)
- A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins. (2006) (132)
- Nonalcoholic steatohepatitis and increased risk of chronic kidney disease. (2011) (131)
- Fenofibrate, a peroxisome proliferator‐activated receptor α agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver (2006) (127)
- Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A (2009) (124)
- Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients (2014) (114)
- Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen (2004) (113)
- Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. (2008) (112)
- Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis (1993) (111)
- Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging (2001) (110)
- Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies (2014) (103)
- Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan (2010) (102)
- Platelet count for predicting fibrosis in nonalcoholic fatty liver disease (2011) (102)
- Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. (2004) (100)
- Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan (2011) (100)
- Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis (2021) (100)
- Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice (2010) (98)
- Hepatitis B virus-related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis (2005) (96)
- Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers (2018) (91)
- Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study (2009) (89)
- The role of the Ito cell in perivenular and intralobular fibrosis in alcoholic hepatitis. (1983) (85)
- Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan (2010) (85)
- PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats. (2004) (83)
- A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. (2005) (82)
- Development of gap junctional channels and intercellular communication in rat liver during ontogenesis. (2000) (80)
- SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. (2010) (79)
- Low serum level of hepatitis B core‐related antigen indicates unlikely reactivation of hepatitis after cessation of lamivudine therapy (2007) (75)
- Liver-infiltrating T lymphocytes are attracted selectively by IFN-inducible protein-10. (2000) (73)
- The combination of elbasvir and grazoprevir for the treatment of chronic HCV infection in Japanese patients: a randomized phase II/III study (2016) (72)
- ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry (2009) (72)
- Detection of YMDD mutant using a novel sensitive method in chronic liver disease type B patients before and during lamivudine treatment. (2002) (71)
- Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD (2006) (70)
- Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan. (2006) (69)
- Possible Involvement of RUNX3 Silencing in the Peritoneal Metastases of Gastric Cancers (2005) (69)
- Role of hepatic iron in non‐alcoholic steatohepatitis (2009) (66)
- High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells. (2011) (66)
- Screening of DNA copy‐number aberrations in gastric cancer cell lines by array‐based comparative genomic hybridization (2005) (66)
- Epidemiology of genotypes of hepatitis C virus in Japanese patients with type C chronic liver diseases: A multi‐institution analysis (1995) (64)
- Dynamics of Hepatitis C Viremia following Interferon-α Administration (1998) (63)
- A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH (2021) (62)
- A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan (2004) (62)
- Association of gankyrin protein expression with early clinical stages and insulin‐like growth factor‐binding protein 5 expression in human hepatocellular carcinoma (2007) (62)
- Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C (2008) (61)
- Human herpesvirus 8-negative malignant effusion lymphoma: A distinct clinical entity and successful treatment with rituximab (2005) (58)
- Rosuvastatin ameliorates high‐fat and high‐cholesterol diet‐induced nonalcoholic steatohepatitis in rats (2013) (57)
- Clinical significance of elevated serum interferon‐ inducible protein‐10 levels in hepatitis C virus carriers with persistently normal serum transaminase levels (2001) (57)
- Efficacy and safety of canagliflozin in type 2 diabetes mellitus patients with biopsy-proven nonalcoholic steatohepatitis classified as stage 1–3 fibrosis (2018) (56)
- Simeprevir (TMC435) once daily with peginterferon‐α‐2b and ribavirin in patients with genotype 1 hepatitis C virus infection: The CONCERTO‐4 study (2015) (56)
- Clinical and pathological progression of non‐alcoholic steatohepatitis to hepatocellular carcinoma (2012) (54)
- Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice. (2006) (53)
- Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection (1999) (53)
- Activation of B‐Myb by E2F1 in hepatocellular carcinoma (2008) (53)
- The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study (2018) (53)
- Role of cell‐cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C (2007) (52)
- The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin‐8 production (2002) (52)
- Reduced Patient-Reported Outcome Scores Associate with Level of Fibrosis in Patients with Nonalcoholic Steatohepatitis. (2019) (51)
- A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. (2004) (51)
- Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C (1996) (50)
- Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-Fed db/db mice (2011) (50)
- Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis. (2006) (49)
- Interferon therapy for aged patients with chronic hepatitis C: improved survival in patients exhibiting a biochemical response (2004) (49)
- Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study. (2006) (49)
- Involvement of Kupffer Cells in the Interaction Between Neutrophils and Sinusoidal Endothelial Cells in Rats (2002) (48)
- Cytokine-induced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats. (2005) (48)
- Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms (2006) (48)
- Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis (2007) (48)
- A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis (2017) (47)
- Scanning electron microscopy of the liver cell cytoskeleton (1985) (47)
- Calcium-associated cytoprotective effect of taurine on the calcium and oxygen paradoxes in isolated rat hepatocytes. (2008) (46)
- Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases. (2001) (45)
- Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis (2020) (45)
- Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats. (2006) (44)
- Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. (2003) (44)
- TNF-α IS A POTENT INDUCER FOR IFN-INDUCIBLE PROTEIN-10 IN HEPATOCYTES AND UNAFFECTED BY GM-CSF IN VIVO, IN CONTRAST TO IL-1β AND IFN-γ (2000) (44)
- Transient biochemical response in interferon therapy decreases the development of hepatocellular carcinoma for five years and improves the long-term survival of chronic hepatitis C patients. (2002) (43)
- Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease (2010) (43)
- Measurement of hepatitis B virus core‐related antigen is valuable for identifying patients who are at low risk of lamivudine resistance (2006) (43)
- Clinicopathological characteristics of esophageal squamous papillomas in Japanese patients--with comparison of findings from Western countries. (2006) (42)
- ENDOGENOUS NITRIC OXIDE PRODUCTION IS AUGMENTED AS THE SEVERITY ADVANCES IN PATIENTS WITH LIVER CIRRHOSIS (1996) (42)
- Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer (2000) (42)
- Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma (2004) (41)
- A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells. (2009) (41)
- The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels. (2010) (40)
- Influence of transfection with connexin 26 gene on malignant potential of human hepatoma cells. (2002) (39)
- Phase 3 drug pipelines in the treatment of non‐alcoholic steatohepatitis (2019) (39)
- Classification of patients with non‐alcoholic fatty liver disease using rapid immunoassay of serum type IV collagen compared with liver histology and other fibrosis markers (2017) (39)
- CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma. (2008) (39)
- Hemodynamic characterization in experimental liver cirrhosis induced by thioacetamide administration (1993) (39)
- Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter (2000) (37)
- Efficacy and tolerability of an IFN-free regimen with DCV/ASV for elderly patients infected with HCV genotype 1B. (2017) (37)
- Ciliated hepatic foregut cyst. A report of one case and a review of the literature. (2003) (37)
- In vivo expression patterns of survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma (2005) (37)
- Intercellular adhesion molecule‐1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rats (1997) (37)
- Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high‐fat diet fed mice (2015) (37)
- Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats. (2004) (36)
- Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels (2013) (35)
- Differences of Hepatocellular Carcinoma Patients with Hepatitis B Virus Genotypes of Ba, Bj or C in Japan (2005) (35)
- Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers. (1996) (35)
- Relationship between hepatocellular carcinoma and subtypes of hepatitis C virus: A nationwide analysis (1996) (35)
- Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms. (2005) (35)
- Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation (2009) (34)
- Autoimmune hepatitis in a patient with systemic lupus erythematosus (2003) (33)
- PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis. (1994) (33)
- Inverse association between Helicobacter pylori infection and allergic rhinitis in young Japanese (2010) (32)
- Relationship of Mallory bodies to intermediate filaments in hepatocytes. A scanning electron microscopy study. (1985) (32)
- Insulin resistance/β‐cell function and serum ferritin level in non‐diabetic patients with hepatitis C virus infection (2003) (32)
- PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma. (2010) (32)
- Circulating HCV-RNA, HCV genotype, and liver histology in asymptomatic individuals reactive for anti-HCV antibody and their follow-up study. (2008) (32)
- TNF-alpha is a potent inducer for IFN-inducible protein-10 in hepatocytes and unaffected by GM-CSF in vivo, in contrast to IL-1beta and IFN-gamma. (2000) (32)
- Functional heterogeneity of rat liver macrophages: interleukin-1 secretion and Ia antigen expression in contrast with phagocytic activity. (2008) (31)
- Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining (2016) (30)
- Hepatic stellate cell nomenclature. (1996) (30)
- Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma (2014) (30)
- Proton magnetic resonance assay of total and taurine-conjugated bile acids in bile. (1999) (30)
- Pathology of acute hepatitis A in humans. Comparison with acute hepatitis B. (1984) (29)
- Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro. (2004) (29)
- Influence of vitamin E on gastric mucosal injury induced by Helicobacter pylori infection (2006) (28)
- Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice (2004) (28)
- Simple tumor profile chart based on cell kinetic parameters and histologic grade is useful for estimating the natural growth rate of hepatocellular carcinoma. (2002) (28)
- Serum levels of macrophage colony stimulating factor (M-CSF) in liver disease. (1994) (28)
- Activated Kupffer cells play an important role in intra-hepatic Th1-associated necro-inflammation in Concanavalin A-induced hepatic injury in mice. (2003) (28)
- Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver. (2007) (27)
- Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus (2009) (26)
- Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts (2008) (26)
- Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis. (2005) (26)
- Role of calcitonin gene-related peptide in the vascular system on the development of the hyperdynamic circulation in conscious cirrhotic rats. (1997) (26)
- Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis (2004) (26)
- Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy. (2005) (26)
- A role of mast cells for hepatic fibrosis in primary sclerosing cholangitis. (2005) (25)
- Hyperthermia enhances tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line. (2003) (25)
- Prevention by Rebamipide of Acute Reflux Esophagitis in Rats (2005) (25)
- Influence of lifestyle‐related diseases and age on the development and progression of non‐alcoholic fatty liver disease (2015) (25)
- Time course profile and cell-type-specific production of monokine induced by interferon-gamma in Concanavalin A-induced hepatic injury in mice: comparative study with interferon-inducible protein-10. (2001) (25)
- Hepatic damage induced by transcatheter arterial chemoembolization elevates serum concentrations of macrophage-colony stimulating factor. (1999) (25)
- Current and new pharmacotherapy options for non-alcoholic steatohepatitis (2020) (25)
- Vector potential of cockroaches for Helicobacter pylori infection (2003) (24)
- Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis (2021) (24)
- Long-term (>=2 yr) efficacy of vitamin E for non-alcoholic steatohepatitis. (2013) (24)
- CV-11974, angiotensin II type I receptor antagonist, protects against ischemia-reperfusion injury of the small intestine in rats. (2006) (24)
- Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C (2008) (24)
- Chronic active hepatitis with histological features of primary biliary cirrhosis (1987) (24)
- Lower circulating levels of dehydroepiandrosterone, independent of insulin resistance, is an important determinant of severity of non‐alcoholic steatohepatitis in Japanese patients (2010) (23)
- Serum levels of soluble tumor necrosis factor receptors and effects of interferon therapy in patients with chronic hepatitis C virus infection. (1999) (23)
- Cytogenetic analyses of hepatocellular carcinoma by in situ hybridization with a chromosome‐specific DNA probe (1996) (23)
- Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B (2009) (23)
- 17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30. (2011) (23)
- Effects of Glycyrrhizin on Glucocorticoid Signaling Pathway in Hepatocytes (2002) (22)
- Fatigue and Pruritus in Patients with Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: The Impact on Patient‐Reported Outcomes (2020) (22)
- Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus (2013) (22)
- Factors associated with the overall survival of elderly patients with hepatocellular carcinoma. (2012) (22)
- Expression of Cytokeratins 7 and 20 in Serrated Adenoma and Related Diseases (2005) (22)
- Significance of pre‐S region–defective hepatitis B virus that emerged during exacerbation of chronic type B hepatitis (1993) (22)
- Effect of Ethanol and Chlorpromazine on Transhepatic Transport and Biliary Secretion of Horseradish Peroxidase (1984) (21)
- Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non‐cirrhotic patients without overt diabetes (2011) (21)
- Hepatocellular carcinoma as a leading cause of cancer-related deaths in Japanese type 2 diabetes mellitus patients (2018) (21)
- Different Changes in the Expression of Multiple Kinds of Tight-Junction Proteins during Ischemia-Reperfusion Injury of the Rat Ileum (2006) (21)
- Insulin resistance/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection. (2003) (21)
- The effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients with refractory factors in the real world: a comprehensive analysis of a prospective multicenter study (2020) (21)
- Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease (2017) (21)
- Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease (2020) (21)
- Accuracy of non‐invasive scoring systems for diagnosing non‐alcoholic steatohepatitis‐related fibrosis: Multicenter validation study (2018) (21)
- Elevated interleukin-6 and gamma-globulin during interferon therapy of hepatitis B. (1992) (21)
- Antiviral activity, dose–response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial (2009) (20)
- Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. (2014) (20)
- In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo. (2006) (20)
- Pathogenic Role of Endothelial Nitric Oxide Synthase (eNOS/NOS-III) in Cerulein-Induced Rat Acute Pancreatitis (2006) (20)
- Molecular characterization of a variant virus that caused de novo hepatitis B without elevation of hepatitis B surface antigen after chemotherapy with rituximab (2008) (20)
- Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C (2010) (20)
- Risk factors and clinical course of portal and/or splenic vein thrombosis after partial splenic embolization (2009) (20)
- Leprdb/db Mice with Senescence Marker Protein-30 Knockout (Leprdb/dbSmp30Y/−) Exhibit Increases in Small Dense-LDL and Severe Fatty Liver Despite Being Fed a Standard Diet (2013) (19)
- Comparison of Clinical Features and Patient Background in Functional Dyspepsia and Peptic Ulcer (2007) (19)
- FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction-Associated Fatty Liver Disease in the Era of the Global Metabodemic (2021) (19)
- The effects of prednisolone and interferons on serum macrophage colony stimulating factor concentrations in chronic hepatitis B. (1997) (19)
- A case of human fasciolosis: discrepancy between egg size and genotype of Fasciola sp (2006) (19)
- A case-control study of response to lamivudine therapy for 2 years in Japanese and Chinese patients chronically infected with hepatitis B virus of genotypes Bj, Ba and C. (2006) (19)
- Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. (2005) (19)
- Anoxia/reoxygenation down-regulates the expression of E-cadherin in human colon cancer cell lines. (2004) (19)
- Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021) (18)
- Serum total bile acid level as a sensitive indicator of hepatic histological improvement in chronic hepatitis C patients responding to interferon treatment (2000) (18)
- Regression of idiopathic thrombocytopenic purpura after endoscopic mucosal resection of gastric mucosa associated lymphoid tissue lymphoma (2004) (18)
- Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C (2015) (18)
- Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan (2021) (18)
- Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-Based Cohort Study. (2022) (18)
- Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2‐nitrobenzenesulfenyl chloride isotope labeling method (2010) (18)
- Dynamics of hepatitis C viremia following interferon-alpha administration. (1998) (17)
- Acute Esophageal Necrosis Followed by Upper Endoscopy and Esophageal Manometry/pH Test (2005) (17)
- Effects of bile acids and taurine on the lipid fluidity of hepatic microsomes in normal and bile duct-ligated rats--a spin label study. (1993) (17)
- Diagnostic accuracy of combined biomarker measurements and vibration-controlled transient elastography (VCTE) for predicting fibrosis stage of non-alcoholic fatty liver disease (2019) (17)
- Effect of pemafibrate on fatty acid levels and liver enzymes in non‐alcoholic fatty liver disease patients with dyslipidemia: A single‐arm, pilot study (2020) (17)
- Involvement of IQGAP3, a regulator of Ras/ERK‐related cascade, in hepatocyte proliferation in mouse liver regeneration and development (2009) (17)
- Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non‐alcoholic fatty liver disease (2020) (17)
- Cholestatic jaundice in two patients with primary amyloidosis: ultrastructural findings of the liver. (1999) (16)
- Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts the development of hepatocellular carcinoma in patients with non‐alcoholic fatty liver disease (2018) (16)
- Epidemiology, Pathogenesis, and Diagnostic Strategy of Diabetic Liver Disease in Japan (2020) (16)
- Distribution of the different subtypes of hepatitis C virus in Japan and the effects of interferon: A nationwide survey (1996) (16)
- Immunohistochemical localization of CEA, CA19‐9 and DU‐PAN‐2 in hepatitis C virus‐infected liver tissues (2002) (16)
- Ability of Cytokeratin-18 Fragments and FIB-4 Index to Diagnose Overall and Mild Fibrosis Nonalcoholic Steatohepatitis in Japanese Nonalcoholic Fatty Liver Disease Patients (2017) (16)
- Management of HBV infection in Japan (2007) (15)
- Solid pseudopapillary tumor as a possible cause of acute pancreatitis. (2004) (15)
- Severe cytomegalovirus enterocolitis after standard chemotherapy for non-Hodgkin's lymphoma (2005) (15)
- Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma (2018) (15)
- Efficacy of telaprevir‐based therapy for difficult‐to‐treat patients with genotype 2 chronic hepatitis C in Japan (2015) (14)
- Interleukin-10 plasmid DNA inhibits subcutaneous tumor growth of Colon 26 adenocarcinoma in mice. (2005) (14)
- Difference in serum complement component C4a levels between hepatitis C virus carriers with persistently normal alanine aminotransferase levels or chronic hepatitis C (2012) (14)
- Experimental Liver Injury Induced by Propionibacterium acnes and Lipopolysaccharide in Macrophage Colony Stimulating Factor-Deficient Osteopetrotic (op/op) Mice (1999) (14)
- Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression. (2004) (14)
- Semaglutide for the treatment of non-alcoholic steatohepatitis: Trial design and comparison of non-invasive biomarkers. (2020) (14)
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- Ultracytochemichal Study of Glucose-6-Phosphate Dehydrogenase Activity (1992) (0)
- Lectin Histochemical Study of Squamous Carcinoma in the Head and Neck Region (1989) (0)
- Heterogeneity of ICG uptake and bile acid excretion within the hepatic lobule. (1984) (0)
- P-393 Relationships between nitroxide radical pharmacokinetics and the changes of pO2 in a mouse liver using in vivo ESR spectroscopy (1995) (0)
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Combination with Recanalization of Portal and Superior Mesenteric Vein Thrombosis Ensured Hassab's Operation for High-Risk Esophago-Gastric Varices (2003) (0)
- IB-11 Diagnostic findings of the liver histology in acute type of autoimmune hepatitis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY) (2005) (0)
- Interferon and nucleoside analog combination therapy for hepatitis B (2010) (0)
- Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease (2023) (0)
- [Evidence based antiviral therapy for chronic hepatitis B]. (2005) (0)
- Cytoskeletal pathology in alcoholic liver damage (1987) (0)
- Transmission and scanning electron microscopy of the human liver cell cytoskeleton. (1987) (0)
- Correction to: Hepatocellular carcinoma diagnosis using a novel electrochemiluminescence immunoassay targeting serum IgM‑free AIM (2022) (0)
- [Accessory liver]. (1995) (0)
- Dynamics of serum thioredoxin levels as an indicator of oxidative stress in patients with chronic hepatitis C (2001) (0)
- Mechanism of the adhesion and migration of neutrophils on sinusoidal endothelial cells in flow system (1995) (0)
- [The past, present and future treatment for chronic hepatitis B]. (2011) (0)
- Immunoelectron microscopic study on heterogeneity of intermediate filaments of human hepatocytes. (1988) (0)
- Abstracts of selected papers presented at the 30th Annual Meeting of the Japanese Society of Gastroenterology October 20–22, 1988 — Kagoshima, Japan (1991) (0)
- 45 Analysis of hepatocarcinogenesis as studied by DNA-RNA cytofluorometry in combination with histochemistry. (1986) (0)
- Examination on the dynamic phase of blood HCV quantity during IFN alfa intravenous injection and the safety. (1998) (0)
- EGF binding activity of rat hepatocytes in liver regeneration after partial hepatectomyCell cycle analysis by cytofluorometry (1993) (0)
- Obesity and Hepatocarcinogenesis (2019) (0)
- Interferon Therapy Practice and Problems of Interferon Therapy —Advanced renal cell carcinoma— (2004) (0)
- ELECTROENDOSCOPIC STUDIES ON THE DEVELOPMENT OF EXPERIMENTAL HEPATOCARCINOGENESIS (1988) (0)
- Thioredoxin as an indicator of oxidative stress in the serum of patients with hepatitis C virus infection (1999) (0)
- [Dysmorphogenesis of intrahepatic bile duct]. (1995) (0)
- [Feulgen-DNA cytofluorometry of the liver cell carcinomas]. (1984) (0)
- Diagnostic and Therapeutic Values of Apoptosis Inhibitor of Macrophage in Nash-Associated Hepatocellular Carcinoma (2018) (0)
- [Prognostic significance of bridging hepatic necrosis in chronic active hepatitis: a follow-up study]. (1983) (0)
- 胃および脾臓へ穿破し,脾膿瘍を合併した膵管内乳頭粘液性腺癌(IPMC)の1例 (2006) (0)
- THU-438-The presence of type 2 diabetes is independently associated with impairment of patient-reported outcomes in patients with non-alcoholic steatohepatitis (2019) (0)
- Subject Index Vol. 72, Suppl. 1, 2007 (2007) (0)
- Abstract #423 Baseline Characteristics of Patients with and Without Diabetes in Trials for Advanced Fibrosis/Cirrhosis Due to Nonalcoholic Steatohepatitis (Nash) (2019) (0)
- Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon‐alpha‐2b and ribavirin combination therapy (2012) (0)
- [Evaluation of plasma PIVKA-II as a new marker for hepatocellular carcinoma]. (1989) (0)
- Cell cycle analysis of EGF binding activity of hepatocytes in liver regeneration. (1991) (0)
- Absence of differences in the recurrence rates of hepatitis C virus‑associated hepatocellular carcinoma between direct‑acting antivirals and interferon‑based treatments: A multicenter study (2021) (0)
- [Present State of Non-B Non-C Liver Disease-and Its Monitoring.] (2016) (0)
- Administration of FR167653, a New Anti-Inflammatory Compound, Inhibits Aspirin-Induced Gastric Mucosal Injury in Rats (2006) (0)
- Impact of a Novel Digital Therapeutics System on Nonalcoholic Steatohepatitis: The NASH App Clinical Trial. (2023) (0)
- [A case of minimal invasive carcinoma from intraductal papillary mucinous neoplasm with invasive ductal carcinoma of the pancreas]. (2006) (0)
- A Simple and Accurate AI System for Screening Nonalcoholic Fatty Liver Disease and Diagnosing Fibrosis Stage of Nonalcoholic Steatohepatitis (2019) (0)
- Letters to the Editor: Reply (2003) (0)
- Fibrosis non-invasive tests capture changes in patient-reported outcomes of patients with advanced non-alcoholic steatohepatitis (2020) (0)
- Electron microscopic and autoradiographic studies on the proliferating biliary epithelial cells in rats after common bile duct ligation. (1977) (0)
- Evidence-based medicine on domestic data (2004) (0)
- Garcin Syndrome Due to Meningeal Carcinomatosis from Gastric Cancer (2020) (0)
- [Antiviral treatment of chronic hepatitis B with adefovir dipivoxil]. (2004) (0)
- P-216 Evaluation of energy metabolism related to bile formation in isolated perfused rat liver using 31P-NMR spectroscopy (1995) (0)
- [A case of pancreatic intraductal papillary-mucinous carcinoma with penetration to the stomach and splenic abscess]. (2006) (0)
- Cell kinetic analysis of hyperplastic lesions appearing in early phase of hepatocarcinogenesis (1989) (0)
- Validation of the utility of Agile scores to identify advanced fibrosis and cirrhosis in Japanese patients with nonalcoholic fatty liver disease. (2023) (0)
- [Treatment of nonalcoholic steatohepatitis (NASH)]. (2004) (0)
- [Review]Psychosomatic aspects of functional gastrointestinal disorders (2003) (0)
- 44 DNA-albumin cytofluorometry applied to the analysis of liver injuries. (1986) (0)
- [A case of Castleman disease arising from lesser sac]. (2004) (0)
- Function of sinusoidal endothelial cells (1994) (0)
- Administration of FR 167653 , a New Anti-Inflammatory Compound , Inhibits Aspirin-Induced Gastric Mucosal Injury in Rats (2006) (0)
- [Indications for antiviral therapy for chronic hepatitis B]. (2007) (0)
- Obstructive jaundice with fever and eosinophilia (2007) (0)
- 2P-0486 Azelnidipine, a novel ca-antagonist, reduces endothelial inflammatory response induced by oxysterol (2003) (0)
- Diagnostic accuracy of enhanced liver fibrosis test for nonalcoholic steatohepatitis‐related fibrosis: Multicenter study (2022) (0)
- Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress (2021) (0)
- Abstracts of selected papers presented at the 34th annual meeting of the Japanese Society of Gastroenterology October 12–14, 1992, Utsunomiya, Japan (1993) (0)
- Cell kinetics of the hyperplastic nodules in rat hepatocarcinogenesis (1987) (0)
- [The impact of direct-acting antiviral therapy on the diagnosis of hepatitis-C virus-associated hepatocellular carcinoma]. (2018) (0)
- Characteristic Endoscopic Findings of Graft Versus Host Disease (2005) (0)
- Effects of glycyrrhizin on the glucocorticoid signal transduction pathway in hepatocytes (2000) (0)
- Clinicopathological and Chromosomal Analysis of Small Intestinal Malignant Lymphoma using Fluorescence in situ Hybridization on Paraffin-Embedded Tissue Sections. (2004) (0)
- T1714 ARHGAP5, a Novel Target for Gene Amplification at 14q12, Promotes Hepatocellular Carcinoma Cell Migration by Inhibiting RHOA Activity (2010) (0)
- Abstracts of selected papers presented at the 34th annual meeting of the japanese society of gastroenterology (1993) (0)
- Evaluation of a Modified Coagulation and Clipping Method To Prevent Postoperative Bleeding After Gastric Endoscopic Submucosal Dissection: A Multicenter Study (2022) (0)
- [Antiviral therapy for liver cirrhosis type B]. (2002) (0)
- DNA-albumin cytofluorometry, and its application to the analysis of liver injury (1985) (0)
- P-39 Characterization of hepatitis C virus core protein (1995) (0)
- Serum Thioredoxin Levels Reflect the Oxidative State of Nonalcoholic Steatohepatitis and Simple Steatosis (2003) (0)
- FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “ (2020) (0)
- Three cases of viral liver injury with a decrease in serum CA19-9 level after antiviral therapy (2012) (0)
- The Expression of c-myc Messenger RNA during Rat Hepatocarcinogenesis (1989) (0)
- Contents Vol. 35, 2017 (2017) (0)
- Reply to the letter by M. Yoneda et al. regarding “Ezetimibe therapy in patients with nonalcoholic steatohepatitis” (2011) (0)
- Contents Vol. 46, 2003 (2003) (0)
- 139 Responsiveness of the hyperplastic nodules and liver cell carcinomas to partial hepatectomy as studied by DNA cytofluorometry. (1986) (0)
- Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease (2023) (0)
- LAPAROSCOPIC EXAMINATION OF INTRAPERITONEAL ADHESION (1991) (0)
- SAT-273-Impact of age on routinely available non-invasive tests for the discrimination of advanced fibrosis due to NASH in the phase 3 STELLAR trials of the ASK1 inhibitor selonsertib (2019) (0)
- Immunoelectron microscopic study of intermediate filaments of hepatocytes in human liver using three kinds of cytokeratin antibodies. (1989) (0)
- Stimulated Kupffer cells attract cytotoxic T lymphocytes (CTL) and increase the adhesion of CTL to sinusoidal endothelial cells (1995) (0)
- Automated quantification of fibrosis-related parameters using dual-photon microscopy replace diagnosis of pathologists in NAFLD. (2020) (0)
- Abstracts of selected papers presented at the 79th general meeting of the Japanese Society of Gastroenterology March 29–31, 1993, Kyoto, Japan (1991) (0)
- 297 Investigation of cholestatic mechanism in hepatic amyloidosis (2004) (0)
- Technique to evaluate the ablation margin area using fusion markers during radiofrequency ablation/microwave ablation for hepatocellular carcinoma (2020) (0)
- Preface (2007) (0)
- Development of a single expandable PEIT needle and its clinical application (2011) (0)
- 2P-0481 Endothelial inflammatory response induced by oxysterol and its inhibition by alacepril, and angiotensin converting enzyme inhibitor (2003) (0)
- Serum thioredoxin as an indicator of iron-induced oxidative stress in chronic viral hepatitis (2000) (0)
- [Two cases of groove pancreatitis with atypical manifestation]. (2004) (0)
- A CASE OF MESENTERIC PANNICULITIS AFTER ENDOSCOPIC POLYPECTOMY FOR SIGMOID COLON POLYP ON A LONG STALK (2006) (0)
- TWO CASES OF RECTAL CARCINOID DETECTED BY ENDOSCOPIC POLYPECTOMY (1986) (0)
- Thirty-Fourth Annual Meeting of the Japanese Society of Gastroenterology October 12–14, 1992, Utsunomiya, Japan (2007) (0)
- 膵管内乳頭粘液性腫瘍(IPMN)の微小浸潤癌に通常型膵管癌を合併した1例 (2006) (0)
- Successful treatment of ruptured hepatocellular carcinoma associated with peritoneal dissemination: A case report (2021) (0)
- Early Detection of Lamivudine Resistant Mutant in Chronic Hepatitis B Patients Using a Novel Sensitive Method (2004) (0)
- [Pathogenesis of portal hypertension in alcoholic liver disease]. (1988) (0)
- Beneficial influence of restraint stress on caerulein-induced pancreatitis in rats: Role of endogenous glucocorticoids (2003) (0)
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What Schools Are Affiliated With Takeshi Okanoue?
Takeshi Okanoue is affiliated with the following schools: