Tasuku Honjo
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Japanese professor of immunology and genomic medicine
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Tasuku Honjophilosophy Degrees
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#1048
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Philosophy
Tasuku Honjo's Degrees
- Doctorate Medicine Kyoto University
- PhD Medical Chemistry Kyoto University
Why Is Tasuku Honjo Influential?
(Suggest an Edit or Addition)According to Wikipedia, is a Japanese physician-scientist and immunologist. He won the 2018 Nobel Prize in Physiology or Medicine and is best known for his identification of programmed cell death protein 1 . He is also known for his molecular identification of cytokines: IL-4 and IL-5, as well as the discovery of activation-induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.
Tasuku Honjo's Published Works
Published Works
- Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation (2000) (4505)
- Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme (2000) (3405)
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation (2001) (2622)
- Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. (1992) (2591)
- Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade (2002) (2526)
- Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. (1999) (2422)
- Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. (2001) (1639)
- Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2) (2000) (1535)
- Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. (1996) (1412)
- Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer (2007) (1279)
- Notch signalling controls pancreatic cell differentiation (1999) (1195)
- PD-1 and PD-1 ligands: from discovery to clinical application. (2007) (1074)
- Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells* (1999) (1006)
- Generation of lymphohematopoietic cells from embryonic stem cells in culture. (1994) (945)
- Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells (2004) (943)
- Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. (2015) (854)
- Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC) (1998) (761)
- A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application (2013) (746)
- Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. (1993) (746)
- PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells (2004) (700)
- PD‐1:PD‐L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL‐2 (2002) (678)
- Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut (2004) (665)
- The PD-1-PD-L pathway in immunological tolerance. (2006) (665)
- PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine (2001) (664)
- Conservation of the Notch signalling pathway in mammalian neurogenesis. (1997) (646)
- Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. (2002) (619)
- Molecular mechanism of class switch recombination: linkage with somatic hypermutation. (2002) (611)
- Fibulin-5/DANCE is essential for elastogenesis in vivo (2002) (609)
- Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches (2009) (605)
- Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice (2003) (590)
- Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora (2002) (559)
- Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. (2001) (547)
- Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 (2005) (545)
- Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. (2004) (533)
- AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching (2001) (528)
- Intestinal IgA synthesis: regulation of front-line body defences (2003) (526)
- Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. (1995) (525)
- Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H) (1995) (514)
- Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells (2002) (509)
- Disruption of the mouse RBP-J kappa gene results in early embryonic death. (1995) (495)
- Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium (2007) (486)
- PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. (2001) (485)
- AID Is Required for c-myc/IgH Chromosome Translocations In Vivo (2004) (482)
- Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. (1998) (479)
- Molecular cloning of cDNA encoding human interleukin-2 receptor (1984) (467)
- Constitutive Expression of AID Leads to Tumorigenesis (2003) (464)
- B1b lymphocytes confer T cell-independent long-lasting immunity. (2004) (448)
- In situ class switching and differentiation to IgA-producing cells in the gut lamina propria (2001) (446)
- Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase (1999) (444)
- Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke (2009) (438)
- Cancer immunotherapies targeting the PD-1 signaling pathway (2017) (434)
- Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter (1986) (422)
- Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. (1968) (421)
- PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. (2004) (419)
- T-Independent immune response: new aspects of B cell biology. (2000) (419)
- The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus (1998) (409)
- Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 (2008) (406)
- AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts (2002) (403)
- Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. (2005) (403)
- Immunoglobulin class switching (1984) (397)
- PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver (2003) (391)
- Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate (2001) (389)
- Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II (1986) (384)
- AID is required for germinal center–derived lymphomagenesis (2008) (383)
- Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma (2010) (379)
- Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis* (1997) (370)
- B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40 (1993) (357)
- TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells). (1985) (338)
- AID mutant analyses indicate requirement for class-switch-specific cofactors (2003) (337)
- Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus (1993) (336)
- The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors (2008) (334)
- Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 (2004) (317)
- Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling (2004) (315)
- Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction (2003) (310)
- Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. (1997) (309)
- Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice (1992) (301)
- The AID enzyme induces class switch recombination in fibroblasts (2002) (288)
- Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. (2003) (280)
- Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. (2002) (278)
- Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis* (1999) (276)
- Recognition sequence of a highly conserved DNA binding protein RBP-Jx (1994) (271)
- Organization of the constant-region gene family of the mouse immunoglobulin heavy chain (1982) (266)
- IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity (2011) (265)
- Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5* (2000) (260)
- New regulatory co-receptors: inducible co-stimulator and PD-1. (2002) (252)
- Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. (1988) (251)
- Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination. (2002) (251)
- Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity (2017) (250)
- In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors (1996) (249)
- Organization of immunoglobulin heavy chain genes and allelic deletion model. (1978) (244)
- Separate domains of AID are required for somatic hypermutation and class-switch recombination (2004) (243)
- Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells (1987) (242)
- Circular DNA is excised by immunoglobulin class switch recombination (1990) (241)
- Epstein‐Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP‐J kappa, the homologue of Drosophila Suppressor of Hairless. (1994) (240)
- PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice (2011) (240)
- Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. (1996) (237)
- Structure and chromosomal localization of the human PD-1 gene (PDCD1). (1994) (232)
- Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense (2011) (225)
- The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor (1996) (221)
- A transgenic model of autoimmune hemolytic anemia (1992) (220)
- Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. (1998) (218)
- Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. (1995) (217)
- High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. (1996) (215)
- Learning and Memory Deficits in Notch Mutant Mice (2003) (212)
- Regulation of lymphocyte development by Notch signaling (2007) (211)
- Organization and evolution of variable region genes of the human immunoglobulin heavy chain. (1986) (204)
- AID: how does it aid antibody diversity? (2004) (204)
- Structure of human immunoglobulin gamma genes: implications for evolution of a gene family (1982) (198)
- LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein (1998) (195)
- PD-1 deficiency results in the development of fatal myocarditis in MRL mice. (2010) (195)
- The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. (2001) (194)
- The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor (1994) (189)
- A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs (2001) (188)
- DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries* (1999) (186)
- Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III (2000) (186)
- Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse (1994) (185)
- Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage (1998) (184)
- Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease. (1986) (179)
- Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice (2000) (177)
- Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region (2002) (176)
- Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes (1981) (174)
- Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. (1999) (173)
- A novel family of variable region genes of the human immunoglobulin heavy chain. (1987) (173)
- Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling (2007) (172)
- Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. (1987) (171)
- Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene (1979) (167)
- Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement (1985) (167)
- Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. (2004) (167)
- Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease1 (2002) (167)
- Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. (1995) (160)
- DNA Double-Strand Breaks (2002) (158)
- Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas (2005) (158)
- PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo1 (2009) (156)
- Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. (1980) (155)
- Linking class-switch recombination with somatic hypermutation (2001) (155)
- RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development (2010) (153)
- Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. (2000) (150)
- A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif (1989) (149)
- Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins (2000) (148)
- Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. (1994) (146)
- PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti–PD-1 Therapy (2018) (145)
- Role of PD-1 in Immunity and Diseases. (2017) (142)
- The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. (2006) (141)
- Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. (2008) (141)
- Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System (2000) (140)
- Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells (2003) (140)
- Role of AID in tumorigenesis. (2007) (139)
- Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis (2011) (138)
- Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model (2016) (137)
- Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. (1968) (136)
- Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo. (1992) (136)
- B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers (2010) (136)
- Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. (1971) (134)
- Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis (2003) (131)
- Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes. (1987) (131)
- Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. (1999) (130)
- The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. (2006) (129)
- Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. (2006) (129)
- RBP-L, a transcription factor related to RBP-Jkappa (1997) (129)
- Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences (1981) (129)
- Preferential transcription of Xenopus laevis ribosomal RNA in interspecies hybrids between Xenopus laevis and Xenopus mulleri. (1973) (125)
- Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. (2002) (124)
- Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts1 (2005) (122)
- Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members (2001) (120)
- Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells 1 (2003) (120)
- De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination (2003) (119)
- The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development (1992) (118)
- The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow (1993) (118)
- Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. (1997) (118)
- Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. (2007) (117)
- Elimination of Local Macrophages in Intestine Prevents Chronic Colitis in Interleukin-10-Deficient Mice (2003) (114)
- Allogeneic Offspring Produced by Male Germ Line Stem Cell Transplantation into Infertile Mouse Testis1 (2003) (114)
- Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody‐related variable segments in one haplotype. (1991) (113)
- Generation, expansion, migration and activation of mouse B1 cells (2000) (112)
- Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination (2010) (112)
- Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination (2001) (112)
- Origin of immune diversity: genetic variation and selection. (1985) (110)
- Involvement of B-1 cells in mucosal immunity and autoimmunity. (1995) (109)
- AID to overcome the limitations of genomic information (2005) (109)
- Functional conservation of mouse Notch receptor family members (1996) (109)
- Expression of lymphocyte surface IgE does not require switch recombination (1982) (107)
- Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. (1982) (107)
- Negative regulation of activation-induced cytidine deaminase in B cells. (2006) (106)
- Regulation of IgA synthesis at mucosal surfaces. (2004) (106)
- CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. (2003) (103)
- Cloning of human immunoglobulin mu gene and comparison with mouse mu gene. (1980) (102)
- Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF* (1997) (102)
- Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements (1984) (100)
- Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors. (1985) (100)
- Sponge Pax cDNA Related to Pax-2/5/8 and Ancient Gene Duplications in the Pax Family (1998) (100)
- Multiple roles of Notch signaling in cochlear development. (2007) (99)
- Fractalkine and macrophage‐derived chemokine: T cell‐attracting chemokines expressed in T cell area dendritic cells (1999) (98)
- TRIM28 prevents autoinflammatory T cell development in vivo (2012) (98)
- Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. (1967) (97)
- Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines. (1987) (96)
- Functional Assessment of Self-Renewal Activity of Male Germline Stem Cells Following Cytotoxic Damage and Serial Transplantation1 (2003) (96)
- Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch (2004) (95)
- Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice (1997) (94)
- Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjören's syndrome (1996) (93)
- High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia (1999) (92)
- Organ‐specific profiles of genetic changes in cancers caused by activation‐induced cytidine deaminase expression (2008) (92)
- Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development (2012) (92)
- Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. (2006) (90)
- Genomic structure of HTLV (human T‐cell leukemia virus): detection of defective genome and its amplification in MT‐2 cells. (1984) (90)
- Current issues and perspectives in PD-1 blockade cancer immunotherapy (2020) (89)
- Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2 (1998) (89)
- Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines. (1989) (88)
- The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence. (1982) (88)
- Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment (1999) (86)
- Administration of interleukin ‐5 or ‐10 activates peritoneal B‐1 cells and induces autoimmune hemolytic anemia in anti‐erythrocyte autoantibody‐transgenic mice (1995) (86)
- Anti-Programmed Cell Death 1 Antibody Reduces CD4+PD-1+ T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice (2010) (86)
- Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. (1991) (85)
- Rearrangements of Immunoglobulin Genes during Differentiation and Evolution (1981) (84)
- The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. (1993) (84)
- Palindromic but not G-rich sequences are targets of class switch recombination. (2001) (83)
- Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. (1983) (83)
- A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression. (2005) (81)
- Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. (2010) (81)
- PD-L 1 / B 7 H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor ( TCR ) Transgenic CD 8 T Cells (2004) (80)
- Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination (2001) (80)
- Disruption of the mouse RBP-Jκ gene results in early embryonic death (1995) (80)
- Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice (2007) (80)
- Two opposing roles of RBP-J in Notch signaling. (2010) (79)
- Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. (1998) (79)
- Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior (2017) (79)
- Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection (2003) (79)
- STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID. (1965) (79)
- Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. (1990) (79)
- Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. (1996) (78)
- Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40 (2000) (78)
- T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. (2009) (78)
- Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence. (1985) (77)
- B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity (2021) (77)
- TCGF(IL 2)-receptor inducing factor(s). II. Possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I(+) T cell lines. (1985) (76)
- Fibroblast‐dependent growth of mouse mast cells in vitro: Duplication of mast cell depletion in mutant mice of w/wv genotype (1988) (74)
- Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome. (2005) (74)
- Neural precursor cells derived from human embryonic brain retain regional specificity (2004) (74)
- Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice (2002) (74)
- Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome (1980) (74)
- Molecular cloning and structure of the human interleukin-5 gene. (1987) (73)
- Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells (2005) (73)
- AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination (2009) (72)
- Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II. (1987) (72)
- Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region. (1984) (71)
- Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. (1998) (71)
- Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jx (1994) (71)
- Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes (2012) (71)
- Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice (1994) (71)
- Ordering of mouse immunoglobulin heavy chain genes by molecular cloning (1981) (71)
- Microanatomical localization of PD-1 in human tonsils. (2002) (71)
- Quantitative Regulation of Class Switch Recombination by Switch Region Transcription (2001) (70)
- Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. (2008) (69)
- Dispersed localization of D segments in the human immunoglobulin heavy‐chain locus. (1988) (69)
- Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. (2008) (68)
- The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation* (2012) (67)
- Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene (1991) (67)
- Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. (1996) (67)
- Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. (1980) (67)
- The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination (2009) (67)
- Interleukin 4 (IgG1 induction factor): a multifunctional lymphokine acting also on T cells (1987) (67)
- Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection (1986) (66)
- Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice (1988) (66)
- Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. (1981) (65)
- Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. (1996) (65)
- Loss of alleles at loci on chromosome 13 in human primary gastric cancers. (1988) (65)
- Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. (2014) (65)
- Biochemical and immunological characterization of the DNA binding protein (RBP-J kappa) to mouse J kappa recombination signal sequence. (1992) (65)
- Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related (1989) (64)
- Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue. (1993) (63)
- Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability (2015) (63)
- Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8. (1995) (63)
- RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase (2013) (62)
- An Evolutionary View of the Mechanism for Immune and Genome Diversity (2012) (62)
- Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA (1980) (61)
- ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury* (2001) (61)
- Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. (2014) (61)
- The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence. (1991) (60)
- The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription. (2001) (60)
- A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations (2009) (59)
- Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling (2007) (58)
- Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro. (1988) (58)
- Human genetic defects in class-switch recombination (hyper-IgM syndromes). (2001) (58)
- Structure and Function of Interleukin 4 and 5 (1988) (58)
- Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells* (2003) (58)
- Unique and unprecedented recombination mechanisms in class switching. (2000) (57)
- Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5' flanking region. (1990) (57)
- Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide (1992) (57)
- Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells (2005) (57)
- Notch receptor cleavage depends on but is not directly executed by presenilins (2002) (57)
- Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences. (1993) (56)
- Frequent but biased class switch recombination in the Sμ flanking regions (1998) (56)
- Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice (2000) (55)
- Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. (1989) (54)
- Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model. (1986) (54)
- Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin Jx segment (1989) (54)
- Poly adenosine diphosphate ribose synthesis associated with chromatin. (1968) (54)
- Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase. (2003) (54)
- AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements (2007) (54)
- Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age (2011) (53)
- Regulation of B cell development by Notch/RBP-J signaling. (2003) (53)
- Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. (1996) (52)
- Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster. (1981) (52)
- Deletion of immunoglobulin heavy chain genes accompanies the class switch rearrangement. (1980) (52)
- Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice (1989) (51)
- Regulation of murine IgE production in SJA/9 and nude mice. Potentiation of IgE production by recombinant interleukin 4. (1987) (50)
- Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice (2002) (50)
- Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. (2005) (49)
- Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. (1974) (49)
- Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice. (1999) (48)
- The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer. (1981) (48)
- The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse. (1982) (48)
- Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response (2013) (48)
- Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes. (1984) (47)
- Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1 (2011) (47)
- Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA1 (2000) (47)
- Malaria: Drugs, Disease and Post-genomic Biology (2005) (47)
- Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice (2005) (47)
- Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (2011) (47)
- Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. (2019) (47)
- PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice (2008) (47)
- DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. (2005) (47)
- Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. (1990) (47)
- Transcription of Xenopus chromatin by homologous ribonucleic acid polymerase: aberrant synthesis of ribosomal and 5S ribonucleic acid. (1974) (46)
- Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. (2005) (46)
- Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains. (1982) (45)
- Nucleotide sequence divergence of mouse immunoglobulin gamma 1 and gamma 2b chain genes and the hypothesis of intervening sequence-mediated domain transfer. (1980) (45)
- Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes. (1982) (45)
- Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation (2011) (45)
- De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. (2004) (44)
- Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants (1975) (43)
- Molecular cloning and structure of the human interleukin 2 receptor gene. (1985) (43)
- Reconstitution of antigen-specific suppressor activity with translation products of mRNA (1982) (43)
- Structures of defective P transposable elements prevalent in natural Q and Q-derived M strains of Drosophila melanogaster. (1985) (42)
- Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (2009) (42)
- Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. (2010) (42)
- Rejuvenating Exhausted T Cells during Chronic Viral Infection (2006) (42)
- Nucleotide sequences of immunoglobulin-epsilon pseudogenes in man and apes and their phylogenetic relationships. (1989) (42)
- The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene. (1983) (41)
- Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination (2009) (41)
- Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination* (2007) (41)
- Induction and regulation of immunoglobulin expression in a murine pre-B cell line, 70Z/3. I. Cell cycle-associated induction of sIgM expression and kappa-chain synthesis in 70Z/3 cells by LPS stimulation. (1980) (41)
- Introduction of Human γ1 Immunoglobulin Genes into Fertilized Mouse Eggs (1984) (40)
- The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. (2007) (40)
- Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA. (1985) (40)
- Effects of the deregulated expression of human interleukin-2 in transgenic mice. (1989) (40)
- Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro (1996) (40)
- Organization of the human immunoglobulin heavy-chain locus. (1996) (39)
- Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution. (1987) (39)
- Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants (2008) (38)
- Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation (2013) (38)
- Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus (1997) (38)
- Long terminal repeat‐like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. (1982) (38)
- HTLV‐1 p27rex stabilizes human interleukin‐2 receptor alpha chain mRNA. (1990) (38)
- Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9 (1991) (38)
- The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination (2012) (38)
- Preferential Localization of Human CD5+ B Cells in the Peritoneal Cavity (1997) (37)
- Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP (2007) (37)
- Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins (2016) (36)
- Immunoglobulin heavy chain loci of mouse and human (1995) (36)
- The AID dilemma: infection, or cancer? (2012) (36)
- AID−/−μs−/− Mice Are Agammaglobulinemic and Fail to Maintain B220−CD138+ Plasma Cells1 (2007) (36)
- Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS. (2001) (36)
- Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. (1992) (36)
- Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (1998) (35)
- Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene (2000) (35)
- Loss of immunostaining of the RBP-J kappa transcription factor upon F9 cell differentiation induced by retinoic acid. (1995) (35)
- Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease. (1994) (34)
- The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints. (1993) (34)
- Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells1 (2001) (34)
- Evidence for regulation of transcription and replication of the human neurotropic virus JCV genome by the human S(mu)bp-2 protein in glial cells. (1997) (34)
- Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child (2021) (34)
- Absence of gross change in primary DNA sequence during aging process of mice (1985) (34)
- Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs. (1996) (34)
- Regulation of class switch recombination of the immunoglobulin heavy chain genes (1995) (34)
- Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus (2000) (34)
- Chromosomal mapping of the mouse IL-4 and human IL-5 genes. (1989) (33)
- 7 – Constant-Region Genes of the Immunoglobulin Heavy Chain and the Molecular Mechanism of Class Switching (1989) (33)
- A truncated immunoglobulin epsilon pseudogene is found in gorilla and man but not in chimpanzee. (1985) (33)
- Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture (1991) (33)
- Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa. (1994) (32)
- Signal sequence trap. Expression cloning method for secreted proteins and type 1 membrane proteins. (1997) (32)
- A soluble 'anchorminus' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses. (1988) (32)
- Isolation and characterization of endonuclease J: a sequence-specific endonuclease cleaving immunoglobulin genes. (1984) (32)
- A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment. (1982) (32)
- A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor (1988) (32)
- Expression of interleukin 2 receptors on interleukin 3-dependent cell lines. (1986) (32)
- Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (1983) (32)
- RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells (2003) (32)
- T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells. (1987) (32)
- SL/KH strain of mice: a model of spontaneous pre-B-lymphomas. (1993) (31)
- Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. (1968) (31)
- Expression of human immunoglobulin E ε chain cDNA in E.coli (1983) (31)
- Organization of the Human Immunoglobulin Heavy-Chain Locus (1996) (31)
- Identification of a Specific Domain Required for Dimerization of Activation-induced Cytidine Deaminase* (2006) (30)
- Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (1998) (30)
- X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells (2010) (30)
- Concerted evolution of the mouse immunoglobulin gamma chain genes. (1984) (30)
- Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences (1985) (30)
- Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome (1993) (30)
- Structure and Function of the Interleukin 2 Receptor: Affinity Conversion Model (1986) (29)
- A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain. (2003) (29)
- Involvement of Fractalkine/CX3CL1 Expression by Dendritic Cells in the Enhancement of Host Immunity against Legionella pneumophila (2005) (29)
- C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion (2014) (29)
- The organization and diversity of immunoglobulin genes. (1974) (29)
- APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination (2014) (29)
- Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity (1989) (29)
- Response to Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch" (2004) (28)
- Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. (1969) (28)
- AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model (2010) (28)
- Structure of the mutant fibrillin-1 gene in the tight skin (TSK) mouse. (1997) (27)
- Polymorphism in distribution and structure of P elements in natural populations of Drosophila melanogaste in and around Japan (1984) (27)
- The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. (1987) (27)
- Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation. (1988) (27)
- Mapping of the nu gene using congenic nude strains and in situ hybridization (1992) (27)
- Enzymatic ADP-ribosylation of proteins and regulation of cellular activity. (1973) (26)
- Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. (2004) (26)
- Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment. (1988) (26)
- Intracisternal Type A Particle-Mediated Activation of the Notch4/int3 Gene in a Mouse Mammary Tumor: Generation of Truncated Notch4/int3 mRNAs by Retroviral Splicing Events (1999) (26)
- Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. (1994) (26)
- Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. (1999) (26)
- Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy (2019) (26)
- Differential modulation of cyclin‐dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40 (1996) (26)
- Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons. (1997) (26)
- Organization and reorganization of immunoglobulin heavy-chain genes. (1981) (26)
- Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein. (1984) (25)
- Biochemical evidence for a third chain of the interleukin-2 receptor. (1991) (25)
- Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma (2019) (25)
- Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase (2015) (24)
- Induction of Germline Transcription in the Human TCRγ Locus by STAT51 (2001) (24)
- Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis (1999) (24)
- RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis. (2009) (24)
- The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. (1995) (24)
- Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor (1985) (24)
- Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice. (1998) (24)
- Molecular mechanism for generation of antibody memory (2009) (23)
- Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum (1986) (23)
- Does AID need another aid? (2002) (23)
- Synthesis and regulation of trans‐mRNA encoding the immunoglobulin ∊ heavy chain (1993) (23)
- Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination. (1979) (23)
- Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (1988) (23)
- Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes (1982) (22)
- Transgenic mouse models for B-cell dominant autoimmune diseases. (1997) (22)
- Carboxy-terminal domain of AID required for its mRNA complex formation in vivo (2009) (22)
- Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP. (1998) (21)
- Isolation of DNA clones revealing restriction fragment length polymorphisms in the human genome (1986) (21)
- In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression (2013) (21)
- Molecular mechanism of immunoglobulin class switch recombination. (1999) (21)
- Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay. (1988) (21)
- Expression and functional characterization of artificial mutants of interleukin-2 receptor (1987) (21)
- B‐1 Cells and Autoimmunity a (1995) (21)
- Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes. (1987) (21)
- An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes. (1989) (21)
- Molecular cloning and nucleotide sequencing of human immunoglobulin € chain cDNA (1983) (20)
- The signal sequence trap method. (1999) (20)
- Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase (2014) (20)
- Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice. (1991) (20)
- Mechanism of B1 cell differentiation and migration in GALT. (2000) (20)
- Durable tumor remission in patients with platinum-resistant ovarian cancer receiving nivolumab. (2015) (20)
- The molecular mechanisms of the immunoglobulin class switch. (1982) (19)
- The PD-1 / PD-L 1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors (2008) (19)
- Stoichiometric utilization of adenosine 5'-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl-1-pyrophosphate. (1966) (19)
- Interleukin 1α mRNA in virus-transformed T and B cells (1986) (19)
- Murine leukemia provirus‐mediated activation of the Notch1 gene leads to induction of HES‐1 in a mouse T lymphoma cell line, DL‐3 (1999) (19)
- LIM Protein KyoT 2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein (1997) (19)
- Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice (2020) (19)
- Regulation of B‐1 cell activation and its autoantibody production by Lyn kinase‐regulated signallings (1999) (19)
- Mutual homology of mouse immunoglobulin gamma-chain gene sequences. (1979) (19)
- Establishment of an interleukin‐5‐dependent subclone from an interleukin‐3‐dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin‐5. (1990) (19)
- Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. (1996) (18)
- Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes. (1983) (18)
- Large quantity production with extreme convenience of human SDF‐1α and SDF‐1β by a Sendai virus vector (1998) (18)
- Quantitation of constant and variable region genes for mouse immunoglobulin lambda chains. (1976) (18)
- Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin. (1991) (18)
- Common terminal repeats of the macronuclear DNA are absent from the micronuclear DNA in hypotrichous ciliate, Stylonychia pustulata (1983) (17)
- IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice. (1994) (17)
- Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment. (1989) (17)
- Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines. (1982) (17)
- Plasma cell leukaemia of non‐producer type with missing light chain gene rearrangement (1988) (16)
- Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice. (1994) (16)
- Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus. (1988) (16)
- Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. (1977) (16)
- Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene. (1988) (16)
- Development of erythroid cells from mouse embryonic stem cells in culture: potential use for erythroid transcription factor study. (1997) (16)
- Cloning of a human immunoglobulin gene fragment containing both VH‐D and D‐JH rearrangements: Implication for VH‐D as an intermediate to VH‐D‐JH formation (1993) (16)
- Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B cell precursor (1987) (16)
- Human S mu binding protein-2 binds to the drug response element and transactivates the human apoA-I promoter: role of gemfibrozil. (1998) (16)
- Molecular cloning and structure of the mouse interleukin-5 gene. (1988) (16)
- Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia. (1996) (16)
- Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. (1987) (16)
- Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice (2021) (15)
- Purification and translation of an immunoglobulin lambda chain messenger RNA from mouse myeloma. (1976) (15)
- Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination. (2014) (14)
- Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes. Evidence for recent reshuffling. (1994) (14)
- Suppressor of Hairless, the Drosophila homologue of RBP-Jκ, transactivates the neurogenic gene E(spl)m8 (1995) (14)
- A unique monoclonal antibody derived from a lupus-prone mouse with multiple bindings to autoantigens associated with rheumatic disease. (1988) (14)
- The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor alpha subunit mRNA by p27rex. (1991) (14)
- The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome (2007) (14)
- Expression of murine IL-2 receptor beta-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor alpha-chain transgenic mice. (1990) (14)
- A memoir of AID, which engraves antibody memory on DNA (2008) (14)
- Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic mu chain and constant regions of endogenous isotypes. (1991) (14)
- CHAPTER 20 – Molecular Mechanism of Class Switch Recombination (2004) (13)
- Loss of genes on the long arm of chromosome 22 in human meningiomas. (1988) (13)
- Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability. (2012) (13)
- Immunoglobulin γ1 heavy chain gene: Structural gene sequences cloned in a bacterial plasmid (1980) (13)
- Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes (2017) (12)
- A Transgenic Model of Autoimmune Hemolytic Anemia By Masaya Okamoto,* Masao Murakami,~ Akira Shimizu,S (1992) (12)
- Immunoglobulin switch region-like sequences in Drosophila melanogaster. (1982) (12)
- Differential roles of cytokine receptors in the development of epidermal gamma delta T cells. (2001) (12)
- Both B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line. (1988) (12)
- Regulation of AID function in vivo. (2007) (12)
- Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase. (1998) (12)
- ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice (2000) (12)
- Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function. (2007) (11)
- Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma. (1991) (11)
- Stepwise formation of the high-affinity complex of the interleukin 2 receptor. (1990) (11)
- Purification of immunoglobulin heavy chain messenger RNA by immunoprecipitation from the mouse myeloma tumor, MOPC-31C. (1977) (11)
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- Structure of a rearranged yl chain gene and its implication to immunoglobulin class-switch mechanism (gene cloning/nucleotide sequence determination/repetitive sequence/sister-chromatid-exchange model) (2016) (0)
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- The bcl-2 Gene Product Inhibits Clonal Deletion of Serf-reactive B Lyrnphocytes in the Periphery but Not in the Bone Marrow By Sazuku Nisitani, (2003) (0)
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- Genetic rearrangements (VDJ/CSR/SHM) (WS-080) Chairpersons: Ji-Yang Wang, Satoshi Takaki (2010) (0)
- H 3 K 4 me 3 mark regulated by the FACT complex is critical for DNA cleavage in class switch recombination (2017) (0)
- Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models( Dissertation_全文 ) (2022) (0)
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- Title AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination (2021) (0)
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- Apurinic⁄Apyrimidinic endonuclease 1 (APE1) ′s enrollment in activation induced cytidine deaminase (AID) – dependent IgH gene diversification (2017) (0)
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- A process for the preparation of a cDNA library (1994) (0)
- OJ-507 Autoantibodies against Cardiac Troponin I are the Critical Role for Autoimmune Dilated Cardiomyopathy(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese)) (2004) (0)
- Immunoglobulin Genes Move during Differentiation as well as Evolution (1983) (0)
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- Comparison of immunoglobulin .GAMMA.1 and .GAMMA.2b chain genes cloned from newborn mouse. Evolutional divergence of intervening sequences and structural basis for recognition of splicing sites.:Evolutional Divergence of Intervening Sequences and Structural Basis for Recognition of Splicing Sites (1979) (0)
- Lymphocyte Differentiation and Gene Rearrangement (1983) (0)
- 3 MOLECULAR MECHANISM OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION (1999) (0)
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- PL 03.01 Serendipities of Acquired Immunity (2017) (0)
- Cloning of mouse immunoglobulin E gene and its location within the heavy chain gene cluster ( IgE hybridoma / nucleotide sequence determination / deletion of heavy chain genes / gene walldng ) (0)
- Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers (1989) (0)
- Identification of a new class of chemokine expressed in murine dendritic cells by the signal sequence trap method (1998) (0)
- (cloning/nucleotide sequence/recombination site/S region/js-chain gene) (0)
- Nucleetide sequences of gene-segments encoding membrane domains of immunoglobulin y chains (2003) (0)
- Costimulation (WS-102) Chairpersons: Miyuki Azuma, Tania Watts (2010) (0)
- IMMUNO-ONCOLOGY SURVIVAL MODELLING AND NICE ASSESSMENT: GET AHEAD OF THE CURVE (2018) (0)
- IS-KL2 Modulation of Immune Responses by PD-1, an Immuno-inhibitory receptor(Eosinophils, other Inflammatory Cells and Molecules in Allergy Keynote Lecture 2) (2009) (0)
- Comparison o f Immunoglobulin 11 and r 2 b Chain Genes Cloned from Newborn Mouse Evolutional Divergence o f Intervening Sequences and Structural Basis for Recognition of Splicing Sites (2006) (0)
- RBP-J promotes neuronal differentiation in adult neurogenesis (2009) (0)
- SLE and other connective tissue diseases (animal models) (WS-017) Chairpersons: Takayuki Sumida, Sachiko Hirose (2010) (0)
- The Role of Programmed Death-1 (PD-1)/PD-L Pathway in Regulation of Murine Experimental Autoimmune Uveoretinitis (EAU) (2008) (0)
- The 20th IUBMB International Congress in Kyoto (2006) (0)
- 24: PD-1 is required to induce peripheral CD8 T cell tolerance in recipients of allogeneic bone marrow transplantation with anti-CD154 (2007) (0)
- Intragraft immunoregulation-differential mechanisms of tolerance between human liver transplantation and intestinal transplantation (2007) (0)
- PD-1 regulates self-tolerance to prevent tissue destruction (1998) (0)
- Abstract 5093: Chemically inducible splice-neoantigens for cancer immunotherapy (2023) (0)
- Multiple DNAfragment polymorphisms associated with immunoglobulin 1Lchainswitch-like regions inman (1983) (0)
- Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. (1980) (0)
- [Structure and expression of the antibody gene]. (1984) (0)
- Of human and mammalian stem cells derived neural überlebenspolypeptide (2002) (0)
- Title Chromatin remodeller SMARCA 4 recruits topoisomerase 1 andsuppresses transcription-associated genomic instability (2019) (0)
- [Molecular genetic basis for immune diversity]. (1985) (0)
- [Interleukin 4--special reference to the cloning of genes]. (1986) (0)
- Carnitine palmitoyltransferase I protects from apoptosis mediated by de novo synthesis of ceramide (1996) (0)
- Genetic characterization of Drosophila RBP-J κ (Suppressor of Hairless) as a neurogenic gene in adult PNS development (2004) (0)
- Nucleic Acids Research (2010) (0)
- Nucleic Acids Research found in lymphoid cells (11,12) but the purification (0)
- the Lupus-Like Nephritis of NZB/W F1 Mice T Cells and Relieves + PD-1+ Reduces CD4 Anti-Programmed Cell Death 1 Antibody (2010) (0)
- Recent Developments in Domestic Tax Laws (2007) (0)
- Screening procedures for remedy against heart disease and medicinal composition for treatment of heart disease (2004) (0)
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