Tasuku Honjo | Academic Influence

Why Is Tasuku Honjo Influential?

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According to Wikipedia, is a Japanese physician-scientist and immunologist. He won the 2018 Nobel Prize in Physiology or Medicine and is best known for his identification of programmed cell death protein 1 . He is also known for his molecular identification of cytokines: IL-4 and IL-5, as well as the discovery of activation-induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.

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Tasuku Honjo's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation (2000) (4405)
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme (2000) (3362)
PD-L2 is a second ligand for PD-1 and inhibits T cell activation (2001) (2553)
Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. (1992) (2525)
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade (2002) (2448)
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. (1999) (2376)
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. (2001) (1608)
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2) (2000) (1526)
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. (1996) (1384)
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer (2007) (1257)
Notch signalling controls pancreatic cell differentiation (1999) (1186)
PD-1 and PD-1 ligands: from discovery to clinical application. (2007) (1036)
Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells* (1999) (992)
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells (2004) (936)
Generation of lymphohematopoietic cells from embryonic stem cells in culture. (1994) (936)
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. (2015) (816)
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC) (1998) (760)
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. (1993) (744)
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application (2013) (716)
PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells (2004) (691)
PD‐1:PD‐L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL‐2 (2002) (670)
The PD-1-PD-L pathway in immunological tolerance. (2006) (659)
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut (2004) (653)
Conservation of the Notch signalling pathway in mammalian neurogenesis. (1997) (647)
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine (2001) (642)
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. (2002) (611)
Fibulin-5/DANCE is essential for elastogenesis in vivo (2002) (607)
Molecular mechanism of class switch recombination: linkage with somatic hypermutation. (2002) (602)
Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches (2009) (600)
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice (2003) (581)
Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora (2002) (549)
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. (2001) (544)
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 (2005) (540)
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching (2001) (528)
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. (2004) (527)
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. (1995) (522)
Intestinal IgA synthesis: regulation of front-line body defences (2003) (520)
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H) (1995) (511)
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells (2002) (505)
Disruption of the mouse RBP-J kappa gene results in early embryonic death. (1995) (493)
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium (2007) (480)
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. (2001) (476)
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo (2004) (476)
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. (1998) (469)
Molecular cloning of cDNA encoding human interleukin-2 receptor (1984) (466)
Constitutive Expression of AID Leads to Tumorigenesis (2003) (463)
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria (2001) (441)
B1b lymphocytes confer T cell-independent long-lasting immunity. (2004) (441)
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase (1999) (440)
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke (2009) (434)
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter (1986) (421)
Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. (1968) (419)
T-Independent immune response: new aspects of B cell biology. (2000) (417)
Cancer immunotherapies targeting the PD-1 signaling pathway (2017) (406)
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. (2004) (402)
The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus (1998) (402)
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts (2002) (401)
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 (2008) (399)
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. (2005) (397)
Immunoglobulin class switching (1984) (396)
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver (2003) (385)
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II (1986) (384)
Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate (2001) (383)
AID is required for germinal center–derived lymphomagenesis (2008) (381)
Tumor cell expression of programmed cell death‐1 ligand 1 is a prognostic factor for malignant melanoma (2010) (368)
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis* (1997) (368)
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40 (1993) (351)
AID mutant analyses indicate requirement for class-switch-specific cofactors (2003) (337)
TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells). (1985) (336)
Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus (1993) (336)
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 (2004) (315)
Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling (2004) (313)
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors (2008) (311)
Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction (2003) (307)
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. (1997) (307)
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice (1992) (300)
The AID enzyme induces class switch recombination in fibroblasts (2002) (287)
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. (2003) (277)
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis* (1999) (276)
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. (2002) (275)
A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. (2001) (273)
Recognition sequence of a highly conserved DNA binding protein RBP-Jx (1994) (271)
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain (1982) (266)
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5* (2000) (259)
IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity (2011) (257)
Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. (1988) (250)
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors (1996) (249)
New regulatory co-receptors: inducible co-stimulator and PD-1. (2002) (249)
Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination. (2002) (247)
Organization of immunoglobulin heavy chain genes and allelic deletion model. (1978) (244)
Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells (1987) (242)
Circular DNA is excised by immunoglobulin class switch recombination (1990) (241)
Epstein‐Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP‐J kappa, the homologue of Drosophila Suppressor of Hairless. (1994) (239)
Separate domains of AID are required for somatic hypermutation and class-switch recombination (2004) (239)
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. (1996) (234)
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity (2017) (231)
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice (2011) (228)
Structure and chromosomal localization of the human PD-1 gene (PDCD1). (1994) (224)
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor (1996) (220)
A transgenic model of autoimmune hemolytic anemia (1992) (219)
Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense (2011) (219)
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. (1995) (217)
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. (1998) (216)
High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells. (1996) (211)
Regulation of lymphocyte development by Notch signaling (2007) (209)
Learning and Memory Deficits in Notch Mutant Mice (2003) (209)
Organization and evolution of variable region genes of the human immunoglobulin heavy chain. (1986) (203)
AID: how does it aid antibody diversity? (2004) (203)
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family (1982) (198)
LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein (1998) (195)
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. (2001) (193)
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor (1994) (189)
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs (2001) (188)
Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III (2000) (186)
PD-1 deficiency results in the development of fatal myocarditis in MRL mice. (2010) (185)
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries* (1999) (185)
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse (1994) (184)
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage (1998) (183)
Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease. (1986) (178)
Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice (2000) (176)
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. (1999) (174)
A novel family of variable region genes of the human immunoglobulin heavy chain. (1987) (173)
Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region (2002) (173)
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes (1981) (173)
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling (2007) (172)
Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. (1987) (171)
Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy. (2005) (170)
Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement (1985) (167)
Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene (1979) (167)
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease1 (2002) (166)
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. (2004) (165)
Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. (1995) (159)
DNA Double-Strand Breaks (2002) (156)
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. (1980) (155)
Linking class-switch recombination with somatic hypermutation (2001) (155)
PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo1 (2009) (153)
Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas (2005) (152)
Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. (2005) (152)
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development (2010) (149)
A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif (1989) (149)
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. (2000) (148)
Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins (2000) (146)
Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. (1994) (142)
The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy. (2006) (141)
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. (2008) (141)
Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells (2003) (140)
Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System (2000) (139)
Role of AID in tumorigenesis. (2007) (137)
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis (2011) (137)
Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei. (1968) (136)
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo. (1992) (136)
B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers (2010) (135)
Role of PD-1 in Immunity and Diseases. (2017) (134)
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. (1971) (133)
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis (2003) (131)
PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti–PD-1 Therapy (2018) (131)
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes. (1987) (131)
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. (1999) (130)
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model (2016) (130)
Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences (1981) (129)
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. (2006) (129)
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. (2006) (128)
RBP-L, a transcription factor related to RBP-Jkappa (1997) (127)
Preferential transcription of Xenopus laevis ribosomal RNA in interspecies hybrids between Xenopus laevis and Xenopus mulleri. (1973) (124)
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. (2002) (123)
Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts1 (2005) (121)
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members (2001) (120)
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination (2003) (119)
Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells 1 (2003) (118)
Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. (1997) (118)
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development (1992) (118)
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow (1993) (118)
Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. (2007) (116)
Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody‐related variable segments in one haplotype. (1991) (113)
Allogeneic Offspring Produced by Male Germ Line Stem Cell Transplantation into Infertile Mouse Testis1 (2003) (113)
Elimination of Local Macrophages in Intestine Prevents Chronic Colitis in Interleukin-10-Deficient Mice (2003) (113)
Histone Acetylation Determines the Developmentally Regulated Accessibility for T Cell Receptor γ Gene Recombination (2001) (112)
Generation, expansion, migration and activation of mouse B1 cells (2000) (112)
AID to overcome the limitations of genomic information (2005) (109)
Origin of immune diversity: genetic variation and selection. (1985) (109)
Functional conservation of mouse Notch receptor family members (1996) (109)
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination (2010) (109)
Involvement of B-1 cells in mucosal immunity and autoimmunity. (1995) (108)
Expression of lymphocyte surface IgE does not require switch recombination (1982) (107)
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. (1982) (107)
Negative regulation of activation-induced cytidine deaminase in B cells. (2006) (106)
Regulation of IgA synthesis at mucosal surfaces. (2004) (105)
Cloning of human immunoglobulin mu gene and comparison with mouse mu gene. (1980) (102)
CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid. (2003) (101)
Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF* (1997) (101)
Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors. (1985) (100)
Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements (1984) (100)
Sponge Pax cDNA Related to Pax-2/5/8 and Ancient Gene Duplications in the Pax Family (1998) (100)
TRIM28 prevents autoinflammatory T cell development in vivo (2012) (98)
Multiple roles of Notch signaling in cochlear development. (2007) (98)
Terminal Differentiation of Osteoblasts to Osteocytes Is Accompanied by Dramatic Changes in the Distribution of Actin‐Binding Proteins (2004) (98)
Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer. (1967) (97)
Fractalkine and macrophage‐derived chemokine: T cell‐attracting chemokines expressed in T cell area dendritic cells (1999) (96)
Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines. (1987) (96)
Functional Assessment of Self-Renewal Activity of Male Germline Stem Cells Following Cytotoxic Damage and Serial Transplantation1 (2003) (96)
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch (2004) (94)
Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjören's syndrome (1996) (93)
Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice (1997) (93)
High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia (1999) (92)
Organ‐specific profiles of genetic changes in cancers caused by activation‐induced cytidine deaminase expression (2008) (92)
Genomic structure of HTLV (human T‐cell leukemia virus): detection of defective genome and its amplification in MT‐2 cells. (1984) (90)
Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development (2012) (89)
Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2 (1998) (88)
Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines. (1989) (88)
Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. (2006) (87)
The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence. (1982) (87)
Administration of interleukin ‐5 or ‐10 activates peritoneal B‐1 cells and induces autoimmune hemolytic anemia in anti‐erythrocyte autoantibody‐transgenic mice (1995) (86)
Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment (1999) (86)
Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. (1991) (85)
Anti-Programmed Cell Death 1 Antibody Reduces CD4+PD-1+ T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice (2010) (85)
The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. (1993) (83)
Rearrangements of Immunoglobulin Genes during Differentiation and Evolution (1981) (83)
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. (1983) (83)
Palindromic but not G-rich sequences are targets of class switch recombination. (2001) (82)
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression. (2005) (81)
PD-L 1 / B 7 H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor ( TCR ) Transgenic CD 8 T Cells (2004) (81)
Disruption of the mouse RBP-Jκ gene results in early embryonic death (1995) (80)
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination (2001) (80)
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. (2010) (80)
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID. (1965) (79)
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice (2007) (79)
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions. (1998) (79)
Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection (2003) (79)
Current issues and perspectives in PD-1 blockade cancer immunotherapy (2020) (78)
Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40 (2000) (78)
Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. (1990) (78)
Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence. (1985) (77)
Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. (1996) (77)
TCGF(IL 2)-receptor inducing factor(s). II. Possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I(+) T cell lines. (1985) (76)
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior (2017) (75)
Clinical assessment of orthodontic outcomes with the peer assessment rating, discrepancy index, objective grading system, and comprehensive clinical assessment. (2005) (75)
Neural precursor cells derived from human embryonic brain retain regional specificity (2004) (74)
Two opposing roles of RBP-J in Notch signaling. (2010) (74)
Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome (1980) (74)
T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions. (2009) (74)
Fibroblast‐dependent growth of mouse mast cells in vitro: Duplication of mast cell depletion in mutant mice of w/wv genotype (1988) (74)
Molecular cloning and structure of the human interleukin-5 gene. (1987) (73)
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice (2002) (73)
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II. (1987) (72)
Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells (2005) (72)
Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome. (2005) (72)
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jx (1994) (71)
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning (1981) (71)
Analysis of pain level in cases treated with Invisalign aligner: comparison with fixed edgewise appliance therapy (2014) (71)
Microanatomical localization of PD-1 in human tonsils. (2002) (71)
Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region. (1984) (71)
Fluid Shear Stress Induces Less Calcium Response in a Single Primary Osteocyte Than in a Single Osteoblast: Implication of Different Focal Adhesion Formation (2006) (70)
Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice (1994) (70)
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination (2009) (70)
Dispersed localization of D segments in the human immunoglobulin heavy‐chain locus. (1988) (69)
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes (2012) (69)
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. (1998) (69)
Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling. (2008) (68)
Quantitative Regulation of Class Switch Recombination by Switch Region Transcription (2001) (68)
Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. (1996) (67)
Interleukin 4 (IgG1 induction factor): a multifunctional lymphokine acting also on T cells (1987) (67)
Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene (1991) (67)
Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. (1980) (67)
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. (2008) (67)
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination (2009) (67)
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation* (2012) (66)
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. (1981) (66)
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection (1986) (66)
Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice (1988) (66)
Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. (1996) (65)
Loss of alleles at loci on chromosome 13 in human primary gastric cancers. (1988) (65)
Biochemical and immunological characterization of the DNA binding protein (RBP-J kappa) to mouse J kappa recombination signal sequence. (1992) (65)
Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. (2014) (65)
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related (1989) (64)
Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8. (1995) (63)
Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue. (1993) (63)
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase (2013) (61)
Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA (1980) (61)
An Evolutionary View of the Mechanism for Immune and Genome Diversity (2012) (61)
Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. (2014) (61)
ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury* (2001) (61)
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription. (2001) (60)
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability (2015) (60)
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence. (1991) (60)
Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. (2008) (59)
Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro. (1988) (58)
Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells* (2003) (58)
Structure and Function of Interleukin 4 and 5 (1988) (58)
Human genetic defects in class-switch recombination (hyper-IgM syndromes). (2001) (58)
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations (2009) (58)
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling (2007) (57)
Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide (1992) (57)
Unique and unprecedented recombination mechanisms in class switching. (2000) (57)
Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5' flanking region. (1990) (57)
Notch receptor cleavage depends on but is not directly executed by presenilins (2002) (57)
Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells (2005) (57)
Frequent but biased class switch recombination in the Sμ flanking regions (1998) (56)
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences. (1993) (56)
Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice (2000) (55)
Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase. (2003) (54)
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements (2007) (54)
Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model. (1986) (54)
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin Jx segment (1989) (54)
Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. (1989) (54)
Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age (2011) (53)
Poly adenosine diphosphate ribose synthesis associated with chromatin. (1968) (53)
Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. (1996) (52)
Regulation of B cell development by Notch/RBP-J signaling. (2003) (52)
Deletion of immunoglobulin heavy chain genes accompanies the class switch rearrangement. (1980) (52)
Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster. (1981) (52)
Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice (1989) (51)
Activation and Differentiation of Autoreactive B-1 Cells by Interleukin 10 Induce Autoimmune Hemolytic Anemia in Fas-deficient Antierythrocyte Immunoglobulin Transgenic Mice (2002) (50)
Regulation of murine IgE production in SJA/9 and nude mice. Potentiation of IgE production by recombinant interleukin 4. (1987) (50)
B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity (2021) (50)
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. (1974) (49)
Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria. (2005) (49)
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response (2013) (48)
Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice. (1999) (48)
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse. (1982) (48)
The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer. (1981) (48)
Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. (1990) (47)
Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1 (2011) (47)
Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes. (1984) (47)
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice (2008) (47)
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. (2005) (47)
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. (2005) (46)
Malaria: Drugs, Disease and Post-genomic Biology (2005) (46)
Transcription of Xenopus chromatin by homologous ribonucleic acid polymerase: aberrant synthesis of ribosomal and 5S ribonucleic acid. (1974) (46)
Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains. (1982) (45)
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice (2005) (45)
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (2011) (45)
Increased Frequency of Surface IgA-Positive Plasma Cells in the Intestinal Lamina Propria and Decreased IgA Excretion in Hyper IgA (HIGA) Mice, a Murine Model of IgA Nephropathy with Hyperserum IgA1 (2000) (45)
Nucleotide sequence divergence of mouse immunoglobulin gamma 1 and gamma 2b chain genes and the hypothesis of intervening sequence-mediated domain transfer. (1980) (45)
Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes. (1982) (45)
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. (2004) (44)
Hormonal, pH, and Calcium Regulation of Connexin 43–Mediated Dye Transfer in Osteocytes in Chick Calvaria (2007) (44)
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation (2011) (44)
Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants (1975) (43)
Molecular cloning and structure of the human interleukin 2 receptor gene. (1985) (43)
Reconstitution of antigen-specific suppressor activity with translation products of mRNA (1982) (43)
Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. (2019) (43)
Nucleotide sequences of immunoglobulin-epsilon pseudogenes in man and apes and their phylogenetic relationships. (1989) (42)
Structures of defective P transposable elements prevalent in natural Q and Q-derived M strains of Drosophila melanogaster. (1985) (42)
Rejuvenating Exhausted T Cells during Chronic Viral Infection (2006) (42)
Induction and regulation of immunoglobulin expression in a murine pre-B cell line, 70Z/3. I. Cell cycle-associated induction of sIgM expression and kappa-chain synthesis in 70Z/3 cells by LPS stimulation. (1980) (41)
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination* (2007) (41)
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination (2009) (41)
The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene. (1983) (41)
Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. (2010) (41)
Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro (1996) (40)
Introduction of Human γ1 Immunoglobulin Genes into Fertilized Mouse Eggs (1984) (40)
The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. (2007) (40)
Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA. (1985) (40)
Effects of the deregulated expression of human interleukin-2 in transgenic mice. (1989) (40)
Organization of the human immunoglobulin heavy-chain locus. (1996) (39)
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (2009) (39)
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation (2013) (38)
Long terminal repeat‐like elements flank a human immunoglobulin epsilon pseudogene that lacks introns. (1982) (38)
Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9 (1991) (38)
HTLV‐1 p27rex stabilizes human interleukin‐2 receptor alpha chain mRNA. (1990) (38)
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination (2012) (38)
Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution. (1987) (38)
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants (2008) (38)
Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus (1997) (38)
Preferential Localization of Human CD5+ B Cells in the Peritoneal Cavity (1997) (37)
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP (2007) (37)
The Three-Dimensional Morphometry and Cell–Cell Communication of the Osteocyte Network in Chick and Mouse Embryonic Calvaria (2011) (37)
The AID dilemma: infection, or cancer? (2012) (36)
Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene. (1992) (36)
AID−/−μs−/− Mice Are Agammaglobulinemic and Fail to Maintain B220−CD138+ Plasma Cells1 (2007) (36)
Immunoglobulin heavy chain loci of mouse and human (1995) (36)
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins (2016) (35)
Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (1998) (35)
Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS. (2001) (35)
Loss of immunostaining of the RBP-J kappa transcription factor upon F9 cell differentiation induced by retinoic acid. (1995) (35)
Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene (2000) (35)
Evidence for regulation of transcription and replication of the human neurotropic virus JCV genome by the human S(mu)bp-2 protein in glial cells. (1997) (34)
Regulation of class switch recombination of the immunoglobulin heavy chain genes (1995) (34)
The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints. (1993) (34)
Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus (2000) (34)
Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells1 (2001) (34)
Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease. (1994) (34)
Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs. (1996) (34)
Chromosomal mapping of the mouse IL-4 and human IL-5 genes. (1989) (33)
A truncated immunoglobulin epsilon pseudogene is found in gorilla and man but not in chimpanzee. (1985) (33)
7 – Constant-Region Genes of the Immunoglobulin Heavy Chain and the Molecular Mechanism of Class Switching (1989) (33)
Absence of gross change in primary DNA sequence during aging process of mice (1985) (33)
Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture (1991) (33)
T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells. (1987) (32)
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor (1988) (32)
Expression of interleukin 2 receptors on interleukin 3-dependent cell lines. (1986) (32)
Signal sequence trap. Expression cloning method for secreted proteins and type 1 membrane proteins. (1997) (32)
A soluble 'anchorminus' interleukin 2 receptor suppresses in vitro interleukin 2-mediated immune responses. (1988) (32)
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells (2003) (32)
A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment. (1982) (32)
Isolation and characterization of endonuclease J: a sequence-specific endonuclease cleaving immunoglobulin genes. (1984) (32)
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa. (1994) (32)
Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin. (1983) (32)
Organization of the Human Immunoglobulin Heavy-Chain Locus (1996) (31)
Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. (1968) (31)
Expression of human immunoglobulin E ε chain cDNA in E.coli (1983) (31)
SL/KH strain of mice: a model of spontaneous pre-B-lymphomas. (1993) (31)
Runx1 is involved in the fusion of the primary and the secondary palatal shelves. (2009) (31)
X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells (2010) (30)
Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences (1985) (30)
Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (1998) (30)
Identification of a Specific Domain Required for Dimerization of Activation-induced Cytidine Deaminase* (2006) (30)
Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome (1993) (30)
Concerted evolution of the mouse immunoglobulin gamma chain genes. (1984) (30)
Structure and Function of the Interleukin 2 Receptor: Affinity Conversion Model (1986) (29)
A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain. (2003) (29)
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity (1989) (29)
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion (2014) (29)
The organization and diversity of immunoglobulin genes. (1974) (29)
Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. (1969) (28)
AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model (2010) (28)
Involvement of Fractalkine/CX3CL1 Expression by Dendritic Cells in the Enhancement of Host Immunity against Legionella pneumophila (2005) (28)
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination (2014) (28)
Response to Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch" (2004) (28)
Polymorphism in distribution and structure of P elements in natural populations of Drosophila melanogaste in and around Japan (1984) (27)
Effect of human recombinant interleukin 5 and G-CSF on eosinophil colony formation. (1988) (27)
The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. (1987) (27)
Structure of the mutant fibrillin-1 gene in the tight skin (TSK) mouse. (1997) (27)
Mapping of the nu gene using congenic nude strains and in situ hybridization (1992) (27)
Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. (1994) (26)
Organization and reorganization of immunoglobulin heavy-chain genes. (1981) (26)
Differential modulation of cyclin‐dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40 (1996) (26)
Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment. (1988) (26)
Enzymatic ADP-ribosylation of proteins and regulation of cellular activity. (1973) (26)
Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system. (2004) (26)
Intracisternal Type A Particle-Mediated Activation of the Notch4/int3 Gene in a Mouse Mammary Tumor: Generation of Truncated Notch4/int3 mRNAs by Retroviral Splicing Events (1999) (26)
Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. (1999) (26)
Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons. (1997) (26)
Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein. (1984) (25)
Biochemical evidence for a third chain of the interleukin-2 receptor. (1991) (25)
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. (2021) (24)
The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. (1995) (24)
Induction of Germline Transcription in the Human TCRγ Locus by STAT51 (2001) (24)
Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor (1985) (24)
Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis (1999) (24)
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis. (2009) (24)
Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice. (1998) (24)
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase (2015) (23)
Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination. (1979) (23)
Synthesis and regulation of trans‐mRNA encoding the immunoglobulin ∊ heavy chain (1993) (23)
Molecular mechanism for generation of antibody memory (2009) (23)
Does AID need another aid? (2002) (23)
Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum (1986) (23)
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (1988) (23)
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy (2019) (23)
Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes (1982) (22)
Transgenic mouse models for B-cell dominant autoimmune diseases. (1997) (22)
Expression and functional characterization of artificial mutants of interleukin-2 receptor (1987) (21)
Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay. (1988) (21)
Isolation of DNA clones revealing restriction fragment length polymorphisms in the human genome (1986) (21)
Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes. (1987) (21)
Molecular mechanism of immunoglobulin class switch recombination. (1999) (21)
An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes. (1989) (21)
Differentiation of a human eosinophilic leukemia cell line (EoL-1) by a human T-cell leukemia cell line (HIL-3)-derived factor. (1991) (21)
B‐1 Cells and Autoimmunity a (1995) (21)
Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP. (1998) (21)
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo (2009) (21)
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma (2019) (20)
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase (2014) (20)
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice. (1991) (20)
Molecular cloning and nucleotide sequencing of human immunoglobulin € chain cDNA (1983) (20)
The signal sequence trap method. (1999) (20)
Mechanism of B1 cell differentiation and migration in GALT. (2000) (20)
Durable tumor remission in patients with platinum-resistant ovarian cancer receiving nivolumab. (2015) (20)
In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression (2013) (20)
Murine leukemia provirus‐mediated activation of the Notch1 gene leads to induction of HES‐1 in a mouse T lymphoma cell line, DL‐3 (1999) (19)
Interleukin 1α mRNA in virus-transformed T and B cells (1986) (19)
Mutual homology of mouse immunoglobulin gamma-chain gene sequences. (1979) (19)
The molecular mechanisms of the immunoglobulin class switch. (1982) (19)
Stoichiometric utilization of adenosine 5'-triphosphate in nicotinate ribonucleotide synthesis from nicotinate and 5-phosphoribosyl-1-pyrophosphate. (1966) (19)
Establishment of an interleukin‐5‐dependent subclone from an interleukin‐3‐dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin‐5. (1990) (19)
Quantitation of constant and variable region genes for mouse immunoglobulin lambda chains. (1976) (18)
Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress (2012) (18)
Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes. (1983) (18)
Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus. (1996) (18)
Regulation of B‐1 cell activation and its autoantibody production by Lyn kinase‐regulated signallings (1999) (18)
Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin. (1991) (18)
LIM Protein KyoT 2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein (1997) (18)
Large quantity production with extreme convenience of human SDF‐1α and SDF‐1β by a Sendai virus vector (1998) (18)
Common terminal repeats of the macronuclear DNA are absent from the micronuclear DNA in hypotrichous ciliate, Stylonychia pustulata (1983) (17)
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice. (1994) (17)
The PD-1 / PD-L 1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors (2008) (17)
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment. (1989) (17)
Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines. (1982) (17)
Development of erythroid cells from mouse embryonic stem cells in culture: potential use for erythroid transcription factor study. (1997) (16)
Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B cell precursor (1987) (16)
Human S mu binding protein-2 binds to the drug response element and transactivates the human apoA-I promoter: role of gemfibrozil. (1998) (16)
Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. (1977) (16)
Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus. (1988) (16)
Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene. (1988) (16)
Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice. (1994) (16)
Plasma cell leukaemia of non‐producer type with missing light chain gene rearrangement (1988) (16)
Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice (2020) (16)
Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines. (1987) (16)
Molecular cloning and structure of the mouse interleukin-5 gene. (1988) (16)
Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia. (1996) (15)
Purification and translation of an immunoglobulin lambda chain messenger RNA from mouse myeloma. (1976) (15)
Cloning of a human immunoglobulin gene fragment containing both VH‐D and D‐JH rearrangements: Implication for VH‐D as an intermediate to VH‐D‐JH formation (1993) (15)
Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes. Evidence for recent reshuffling. (1994) (14)
Interdisciplinary orthodontic treatment for a patient with generalized aggressive periodontitis: Assessment of IgG antibodies to identify type of periodontitis and correct timing of treatment. (2015) (14)
Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic mu chain and constant regions of endogenous isotypes. (1991) (14)
The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome (2007) (14)
Suppressor of Hairless, the Drosophila homologue of RBP-Jκ, transactivates the neurogenic gene E(spl)m8 (1995) (14)
The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor alpha subunit mRNA by p27rex. (1991) (14)
Expression of murine IL-2 receptor beta-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor alpha-chain transgenic mice. (1990) (14)
A unique monoclonal antibody derived from a lupus-prone mouse with multiple bindings to autoantigens associated with rheumatic disease. (1988) (14)
Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability. (2012) (13)
CHAPTER 20 – Molecular Mechanism of Class Switch Recombination (2004) (13)
A memoir of AID, which engraves antibody memory on DNA (2008) (13)
Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination. (2014) (13)
Immunoglobulin γ1 heavy chain gene: Structural gene sequences cloned in a bacterial plasmid (1980) (13)
Loss of genes on the long arm of chromosome 22 in human meningiomas. (1988) (13)
Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase. (1998) (12)
ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice (2000) (12)
Both B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line. (1988) (12)
Immunoglobulin switch region-like sequences in Drosophila melanogaster. (1982) (12)
A Transgenic Model of Autoimmune Hemolytic Anemia By Masaya Okamoto,* Masao Murakami,~ Akira Shimizu,S (1992) (12)
Differential roles of cytokine receptors in the development of epidermal gamma delta T cells. (2001) (12)
Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma. (1991) (11)
Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines. (1989) (11)
The membrane exons of the pseudo-γ-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the γ1 gene (1991) (11)
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function. (2007) (11)
Critical role of the CD44lowCD62Llow CD8+ T cell subset in restoring antitumor immunity in aged mice (2021) (11)
Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3. (1991) (11)
ENZYMIC PREPARATION OF NICOTINATE ADENINE DINUCLEOTIDE (DEAMIDO-NAD). (1964) (11)
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes (2017) (11)
Purification of immunoglobulin heavy chain messenger RNA by immunoprecipitation from the mouse myeloma tumor, MOPC-31C. (1977) (11)
Transforming growth factor-beta induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation. (1994) (11)
Anti–Red Blood Cell Immunoglobulin Transgenic Mice (1997) (11)
Stepwise formation of the high-affinity complex of the interleukin 2 receptor. (1990) (11)
Regulation of AID function in vivo. (2007) (11)
Heterogeneity and diversity of IgM and IgG lupus anticoagulants in an individual with systemic lupus erythematosus. (1994) (10)
The human immunoglobulin V(H) locus (1999) (10)
Immunogenotypes of Lymphoid Malignancies; the Rearrangement of T Cell Receptor β Chain Gene Can Occur before the γ Chain Gene Rearrangement (1988) (10)
An anonymous single copy chromosome 18 probe associated with a frequent RFLP (D18S5). (1986) (10)
Seppuku and autoimmunity. (1992) (10)
Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells. (1991) (10)
Multiple recombinational events in primate immunoglobulin epsilon and alpha genes suggest closer relationship of humans to chimpanzees than to gorillas (1988) (10)
Rat TAFII31 gene is induced upon programmed cell death in differentiated PC12 cells deprived of NGF. (1997) (10)
High frequency class switching of an lgM + B lymphoma clone CH 12 F 3 to lgA + cells (2005) (10)
Rapid methods for purification of human recombinant interleukin-5 (IL-5) using the anti-murine IL-5 antibody-coupled immunoaffinity column. (1989) (9)
Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion of beta-galactosidase. (1999) (9)
SAMHD1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination (2020) (9)
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice. (2009) (9)
Origin of adult T-cell leukemia virus. Implication for its zoonosis. (1983) (9)
Duplicated immunoglobulin gamma 2a genes in wild mice. (1984) (9)
Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases. (1968) (9)
Introduction of Mouse Cε Genes into Cos-7 Cells and Fertilized Mouse Eggs (1985) (9)
Immunoglobulin gene organization of ultraviolet-illuminated human lymphoblastoid cell lines producing both IgM and IgG. (1984) (9)
Mouse immunoglobulin allotypes: multiple differences between the nucleic acid sequences of the IgEaand IgEballeles (2004) (9)
Identification of a stimulus‐dependent DNase I hypersensitive site between the Iα and Cα exons during immunoglobulin heavy chain class switch recombination (2000) (8)
A Case Report of Multidisciplinary Treatment of an Adult Patient with Bilateral Cleft Lip and Palate (2014) (8)
Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs. (1984) (8)
Shared partners in receptors (1991) (8)
Genetic characterization of Drosophila RBP-J kappa (suppressor of hairless) as a neurogenic gene in adult PNS development. (1994) (8)
Immunobiology of Natural Killer Cell Receptors (2006) (8)
Cloning of cDNA for T-Cell Replacing Factor and Identity with B-Cell Growth Factor II (1986) (8)
Polymorphism of the human immunoglobulin variable region segment V1-4.1 (1993) (8)
Expression of the RAG-2 gene in murine central nervous system tumor cell lines. (1991) (8)
Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis. (2009) (8)
Accumulation of immunoglobulin messenger ribonucleic acid in immunized mouse spleen. (1977) (8)
Molecular mechanism for immunoglobulin double-isotype expression. (1989) (8)
THE ORGANIZATION AND DIVERSITY OF IMMUNOGLOBULIN κ AND λ GENES (1975) (7)
Gut-Associated Lymphoid Tissues (2010) (7)
Induction of germline transcription in the human TCR gamma locus by STAT5. (2001) (7)
Negative co-receptors and ligands (2011) (7)
The Histone Chaperone Spt 6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H 3 K 4 me 3 Regulation * (2012) (7)
The locus for Japanese myotonic dystrophy is also linked to D19S19 on the long arm of chromosome 19. (1990) (7)
Effect of human recombinant interleukin 4 on in vitro granulopoiesis of human bone marrow cells. (1989) (6)
Induced synthesis of immunoglobulin messenger RNA accompanies induction of immunoglobulin production in cultured mouse spleen cells. (1978) (6)
Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. (1979) (6)
Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouse. (1990) (6)
Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene. (1980) (6)
Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition (2021) (6)
Untranslated immunoglobulin kappa light chain mRNA in a lambda light chain-producing mouse myeloma, MOPC104E. (1980) (6)
Hominoid evolution based on the structures of immunoglobulin epsilon and alpha genes. (1986) (6)
Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice. (1988) (6)
Low-affinity IgM antibodies lacking somatic hypermutations are produced in the secondary response of C57BL/6 mice to (4-hydroxy-3-nitrophenyl)acetyl hapten. (2014) (6)
A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor. (1986) (6)
ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice. (2000) (6)
Why are multiple chains required for the interleukin 2 receptor? (1990) (6)
Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination (2017) (6)
RBP-L, a Transcription Factor Related to RBP-J k (1997) (5)
Nucleotide sequences of variable region segments of the immunoglobulin heavy chain of Xenopus laevis. (1987) (5)
A new vector and RNase H method for the subtractive hybridization. (1989) (5)
Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553-563. (2018) (5)
Molecular mechanism for the formation of the high-affinity complex of interleukin 2 and its receptor. (1988) (5)
EXPRESSION AND REARRANGEMENT OF THE a, /3, AND -y CHAIN GENES OF THE T CELL RECEPTOR IN CLONED MURINE LARGE GRANULAR LYMPHOCYTE LINES (1986) (5)
Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland (2015) (5)
OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst (2004) (5)
CD4+CD25+ regulatory T cells : origin, function and therapeutic potential (2005) (5)
RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase (2020) (4)
The T-cell receptor gene rearrangements in T-lineage tumors without OKT-3,4,6,8 markers. (1987) (4)
Identification of a stimulus-dependent DNase I hypersensitive site between the Ialpha and Calpha exons during immunoglobulin heavy chain class switch recombination. (2000) (4)
Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin gamma 2a genes. (1982) (4)
Interleukin 2 and tumor necrosis factor alpha are complementary for proliferation of the hematopoietic stem cell line LyD9. (1992) (4)
Breakage of B cell tolerance and autoantibody production in anti-erythrocyte transgenic mice. (1999) (4)
Large quantity production with extreme convenience of human SDF-1alpha and SDF-1beta by a Sendai virus vector. (1998) (4)
Evolution of Life (1991) (4)
IgE heavy chain constant region genes in atopic dermatitis and senile erythroderma patients (2004) (3)
Immunologic , Chromosomal , and Molecular Genetic Analysis of a Novel Cell Line Derived From Hodgkin ’ s Disease (2005) (3)
Corrigendum to “Runx1 is involved in the fusion of the primary and the secondary palatal shelves” [Dev. Biol. 326 (2009) 392–402] (2009) (3)
Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes. (1991) (3)
3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro (2022) (3)
Bone Marrow Stem Cell Clone LyD9 (1991) (3)
Apurinic/apyrimidinic endonuclease 1 (APE1) is dispensable for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation in the immunoglobulin gene. (2019) (3)
Relationship of human cord blood mononuclear cell lines, established by the HTLV-I integration, to expression of T-cell phenotypes and the T-cell receptor gene rearrangement. (1987) (3)
Introduction of mouse C epsilon genes into Cos-7 cells and fertilized mouse eggs. (1985) (3)
[Transcriptional activity of EBNA2 through RBP-J]. (1997) (3)
Genetic heterogeneity in blast crisis of chronic myelocytic leukemia. (1990) (3)
NUCLEOTIDE SEQUENCES ENCODING MEMBRANE DOMAINS ARE CONSERVED AMONG IMMUNOGLOBULIN GAMMA SUBCLASS GENES (1982) (3)
In Search of the Best Grant System (2005) (2)
Maxillary Advancement for Unilateral Crossbite in a Patient with Sleep Apnea Syndrome. (2015) (2)
Detection of activation-induced cytidine deaminase in gastric epithelial cells infected with cag pathogenicity island-positive Helicobacter pylori (2007) (2)
Diphtheria Toxin-catalyzed Adenosine Diphosphoribosylation of Aminoacyl Transferase II from Rat Liver (1972) (2)
[112th Scientific Meeting of the Japanese Society of Internal Medicine: Special Lecture: Cancer Immunotherapy by PD-1 Antibody]. (2015) (2)
The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR. (2017) (2)
Growth factors involved in lymphocyte differentiation. (1990) (2)
STAT5 interferes with PD-1 transcriptional activation and affects CD8 + T cell sensitivity to PD-1-dependent immunoregulation. (2021) (2)
Identification of a specific domain required for dimerization of activation-induced cytidine deaminase. (2008) (2)
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice (2022) (2)
Anti–PD-1 Antibody Reduces CD4PD-1 T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice (2010) (2)
Improvement in the antibody productivity of human-human hybridomas by transfection with Tac gene (1990) (2)
Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells. (2020) (2)
The membrane exons of the pseudo-gamma-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the gamma 1 gene. (1991) (2)
Purification and Cloning of a Ribosomal RNA Gene Fragment from Mouse DNA (1978) (2)
THE ORGANIZATION OF IMMUNOGLOBULIN GENES (1974) (2)
Production and characterization of the extracytoplasmic portion of the human interleukin-2 receptor. (1986) (2)
Preferential transcription of HTLV-I LTR in cell-free extracts of human T cells producing HTLV-I viral proteins. (1986) (2)
Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines. (1991) (2)
FACT and H3.3 (2013) (2)
Synergy of interleukin-5 with interleukin-2 in the generation of lymphokine-activated killer-cells. (1992) (2)
Facilitation of b Selection and Modiﬁcation of Positive Selection in the Thymus of PD-1–deﬁcient Mice (2000) (2)
The PD‐1 and IL‐10 pathways play a down‐modulatory role in LP‐BM5 retrovirus‐induced murine immunodeficiency syndrome (2008) (2)
Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L (1999) (2)
Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice. (1989) (2)
Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24. (1989) (2)
Gene patterns of immunoglobulin heavy chain in various cell lines and lymphoid malignancies. (1986) (2)
[112] Nicotinate phosphoribosyltransferase from Bakers' yeast (1971) (2)
The cytoplasmic domain of the CD8 α-chain is required for its interaction with p56lck (1990) (2)
Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events (2021) (2)
Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA. (1983) (2)
MHC-Mismatched Cardiac Allografts Acceptance of Partially versus Fully Attenuator and Programmed Death-1 on Differential Effects of B and T Lymphocyte and (2005) (2)
Structure and Function of Lymphokines and Their Receptors (1989) (2)
Oligoclonal Immunoglobulin Gene Rearrangements in Philadelphia Chromosome‐positive Common Acute Lymphoblastic Leukemia (1990) (2)
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models. (2014) (2)
Disruption of the mouse rbp-j gene alters differentiation of cell lineages derived from mesoderm (2000) (1)
HUMAN IMMUNOGLOBULIN GENES1 (1983) (1)
Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes. (1997) (1)
A monoclonal antibody which inhibits growth of T cell lines. (1993) (1)
Interleukin 1 alpha mRNA in virus-transformed T and B cells. (1986) (1)
Crystal Structure of the PD-L1 (2008) (1)
The cytoplasmic domain of the CD8 alpha-chain is required for its interaction with p56lck. (1990) (1)
Isoform Specific Expression of the SDR-1 Protein, α and β in Subregions of Adult Rodent Brain (1999) (1)
mature and immature hematopoietic progenitor and stem cells derived factor-1 induces mobilization of - Plasma elevation of stromal cell (2013) (1)
Development of Blood Cells from Mouse Embryonic Stem Cells in Culture (1996) (1)
Targeting p62ZIP in Marrow Stromal Cells Is Highly Effective at Inhibiting Myeloma Cell Growth and Osteoclast Formation. (2005) (1)
Molecular Mechanisms of AID Function (2015) (1)
Crystal Structure of the PD-1/PD-L1 Complex (2008) (1)
Differentiation of a Precursor Cell with the Germline Context of Immunoglobulin Gene into Immunoglobulin‐Producing Cells in Vitro a (1988) (1)
Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. (1980) (1)
[Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants]. (1999) (1)
An antigen-specific suppressor T cell factor controlled by two genes in the immunoglobulin heavy chain linkage group and in the I-J subregion of the H-2 complex. (1982) (1)
Genetic rearrangements (VDJ/CSR/SHM) (PP-080) (2010) (1)
Deletion of human JK segments by site-specific recombination recognizing the conserved nonamer and heptamer sequences. (1990) (1)
Genetic analysis in a high IgA strain of ddY (HIGA) mice (2002) (1)
Interleukin-2 receptor: structure, function, and expression. (1986) (1)
Introduction and expression of the interleukin 2 receptor (Tac) gene in hematopoietic stem cells with retrovirus vectors. (1988) (1)
Serendipities of Acquired Immunity (2019) (1)
Rearrangement of immunoglobulin yl-chain gene and mechanism for heavy-chain class switch (cloning/nucleotide sequence/recombination site/S region/,u-chain gene) (2016) (1)
Expression of human immunoglobulin E epsilon chain cDNA in E. coli. (1983) (1)
Erratum to: Role of PD-1 in Immunity and Diseases. (2017) (1)
Analysis of steroid 21-hydroxylase gene in five unrelated Japanese patients with 21-hydroxylase deficiency. (1987) (1)
Production of autoantibodies and autoimmune diseases in PD-1 knock-out mice (2004) (0)
[Structure and expression of the antibody gene]. (1984) (0)
produces new chemokines of hematopoietic cells and encoding DNA (1994) (0)
Comparison of Immunoglobulin γ1 and γ2b Chain Genes Cloned from Newborn Mouse (1979) (0)
Corrigendum (2017) (0)
Notch signalling in embryonic and adult hematopoietic stem cells (2004) (0)
B cell selection and autoimmune diseases (1994) (0)
Carnitine palmitoyltransferase I protects from apoptosis mediated by de novo synthesis of ceramide (1996) (0)
[Molecular genetic basis for immune diversity]. (1985) (0)
PD-1 plays a downmodulatory role in a murine immunodeficiency syndrome (2007) (0)
(cloning/nucleotide sequence/recombination site/S region/js-chain gene) (0)
Genetic characterization of Drosophila RBP-J κ (Suppressor of Hairless) as a neurogenic gene in adult PNS development (2004) (0)
Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer (2022) (0)
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c- Fcgr2b (cid:1) / (cid:1) Pdcd1 (cid:1) / (cid:1) mice (2005) (0)
Maturational stage specific immunoglobulin heavy chain gene rearrangements, determined by D and D upstream region gene structures. (1992) (0)
Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers (1989) (0)
Organization ofImmunoglobulin Genes: Reiteration Frequency oftheMouse KChainConstant RegionGene (1974) (0)
Topoisomerase 1 involvement in AID-induced S region cleavage and CSR (ML09) Chairperson: Frederic Alt (2010) (0)
DNA-Binding Protein Transcription by Association with the RBP-J LIM Protein KyoT 2 Negatively Regulates (1997) (0)
Vivo T Cell Anergy In + Production Induces CD 8 PD-1-Mediated Suppression of IL-2 Taku Okazaki and Tasuku Honjo (2009) (0)
The 20th IUBMB International Congress in Kyoto (2006) (0)
H 3 K 4 me 3 mark regulated by the FACT complex is critical for DNA cleavage in class switch recombination (2017) (0)
AID to overcome the limitations of genomic information by introducing somatic DNA alterations (2006) (0)
529 Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin S (cid:2) Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic (2002) (0)
Of human and mammalian stem cells derived neural überlebenspolypeptide (2002) (0)
Nucleic Acids Research found in lymphoid cells (11,12) but the purification (0)
Nephropathy with Hyperserum IgA ( HIGA ) Mice , a Murine Model of IgA and Decreased IgA Excretion in Hyper IgA PropriaPlasma Cells in the Intestinal Lamina Increased Frequency of Surface IgA-Positive Sasayama and Tasuku Honjo (2000) (0)
death-1 inhibits inflammatory helper T cell development through controlling the innate immune response( ) (2022) (0)
Endonuclease J: a site-specific endonuclease cleaving immunoglobulin genes. (1984) (0)
[Cytokines and receptors--their functions, structures and cloning of code genes. Interleukin-4]. (1988) (0)
Intragraft immunoregulation-differential mechanisms of tolerance between human liver transplantation and intestinal transplantation (2007) (0)
XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation (2022) (0)
Programmed Cell Death-1 inhibits inflammatory helper T cell development through controlling the innate immune response Short title: PD-1 inhibits innate inflammation and autoimmunity (2017) (0)
Unexpected Biological Effects of the Deregulated IL-2/IL-2 Receptor System on the Lymphocyte Development (1989) (0)
Genetic rearrangements (VDJ/CSR/SHM) (WS-080) Chairpersons: Ji-Yang Wang, Satoshi Takaki (2010) (0)
[Molecular cloning of cDNAs encoding B-cell growth factors]. (1987) (0)
Close linkage of MEN2A with RBP3 locus in Japanese kindreds (1989) (0)
The Role of Programmed Death-1 (PD-1)/PD-L Pathway in Regulation of Murine Experimental Autoimmune Uveoretinitis (EAU) (2008) (0)
γ the Development of Epidermal Differential Roles of Cytokine Receptors in (2013) (0)
Future of cancer immunotherapy by PD-1 blockade (2018) (0)
Organization and Reorganization of Constant Region Genes of Immunoglobulin Heavy Chains: Genetic Basis for Class Switching (1983) (0)
The role of autoantibodies against cardiac troponin I in autoimmune dilated cardiomyopathy (2004) (0)
Peripheral tolerance and lymphocyte anergy (WS-072) Chairpersons: Takeshi Tsubata, Pamela Ohashi (2010) (0)
The control of immune response against Trypanosoma cruzi by PD-1 inhibitory co-receptor (2009) (0)
The regulation of PD-1/PD-L1 pathway and autoimmune diseases (2001) (0)
TCR-Transgenic T Cells Generation of CD 4 / CD 8 Double-Negative Alters Thymic Development and Enhances Absence of Programmed Death Receptor 1 (2003) (0)
Structure and Function of Interleukins 4 and 5 (1987) (0)
Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice. (1988) (0)
Preface to second edition (1995) (0)
Title In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs (2018) (0)
A process for the preparation of a cDNA library (1994) (0)
Immunoglobulin Genes Move during Differentiation as well as Evolution (1983) (0)
TheRecombination Signal Sequence-Binding Protein RBP-2N Functions asa Transcriptional Repressor SHAOBODOU,XIAOYAZENG,PATRICIACORTES,tHEDIYEERDJUMENT-BROMAGE,i (1994) (0)
T-cells and cancer immunotherapy ( immuno-oncology ) : the 2018 (2018) (0)
Identification of a new class of chemokine expressed in murine dendritic cells by the signal sequence trap method (1998) (0)
PD-1 regulates self-tolerance to prevent tissue destruction (1998) (0)
Apurinic⁄Apyrimidinic endonuclease 1 (APE1) ′s enrollment in activation induced cytidine deaminase (AID) – dependent IgH gene diversification (2017) (0)
Molecular donlng and nudeoddc sequencing of human immunoglobulin e chain cDNA (1983) (0)
Highly sensitive time-resolved immunofluorescence assay for detecting of chemokine (2000) (0)
Structure of a rearranged yl chain gene and its implication to immunoglobulin class-switch mechanism (gene cloning/nucleotide sequence determination/repetitive sequence/sister-chromatid-exchange model) (2016) (0)
Immunopotentiating compositions comprising anti-PD-L1 (2003) (0)
Non-immunoglobulin AID target loci share unique features with immunoglobulin genes (2018) (0)
Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells. (1989) (0)
The bcl-2 Gene Product Inhibits Clonal Deletion of Serf-reactive B Lyrnphocytes in the Periphery but Not in the Bone Marrow By Sazuku Nisitani, (2003) (0)
Involvement of a Negative Coreceptor PD-1 in Autoimmunity and Tumor Surveillance (2003) (0)
Multiple DNAfragment polymorphisms associated with immunoglobulin 1Lchainswitch-like regions inman (1983) (0)
Differentiation of an interleukin 3-dependent precursor cell into myeloid cells as well as B lymphocytes (1990) (0)
RANK is the hematopoietic cell surface determinant that controls the regulation of bone mass and calcium metabolism (2017) (0)
[Mechanism of cellular differentiation--gene conversion model (author's transl)]. (1978) (0)
[Interleukin 4--special reference to the cloning of genes]. (1986) (0)
Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer (2022) (0)
Regulation of Rearrangement and Expression of Immunoglobulin Genes during Lymphocyte Differentiation (1986) (0)
United States Patent ( 19 ) Honjo et al . 54 INTERLEUKIN 2 RECEPTOR AND A (2017) (0)
Costimulation (WS-102) Chairpersons: Miyuki Azuma, Tania Watts (2010) (0)
IS-KL2 Modulation of Immune Responses by PD-1, an Immuno-inhibitory receptor(Eosinophils, other Inflammatory Cells and Molecules in Allergy Keynote Lecture 2) (2009) (0)
Screening procedures for remedy against heart disease and medicinal composition for treatment of heart disease (2004) (0)
Immune and Genome Diversity An Evolutionary View of the Mechanism for (2017) (0)
24: PD-1 is required to induce peripheral CD8 T cell tolerance in recipients of allogeneic bone marrow transplantation with anti-CD154 (2007) (0)
Pseudo-high-affinity IL-2 receptor and growth signal transduction in lymphocytes. (1993) (0)
[114] Enzymatic preparation of nicotinic acid adenine dinucleotide, nicotinic acid ribonucleotide, and nicotinic acid ribonucleoside (1971) (0)
Genetics of autoimmunity (WS-018) Chairpersons: Masato Nose, Rikard Holmdahl (2010) (0)
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models( Dissertation_全文 ) (2022) (0)
Response to 'Domain organization of activation-induced cytidine deaminase' (2003) (0)
Autoimmune Disease Ligand on B Cells Induces Lupus-Like Cutting Edge: Ectopic Expression of CD40 (2001) (0)
IMMUNO-ONCOLOGY SURVIVAL MODELLING AND NICE ASSESSMENT: GET AHEAD OF THE CURVE (2018) (0)
Comparison o f Immunoglobulin 11 and r 2 b Chain Genes Cloned from Newborn Mouse Evolutional Divergence o f Intervening Sequences and Structural Basis for Recognition of Splicing Sites (2006) (0)
Nucleic Acids Research (2010) (0)
The function of methyltransferase FBL in class switch recombination. (2017) (0)
Cancer Immunotherapy by Checkpoint Blockade (2016) (0)
RBP-J promotes neuronal differentiation in adult neurogenesis (2009) (0)
Title Chromatin remodeller SMARCA 4 recruits topoisomerase 1 andsuppresses transcription-associated genomic instability (2019) (0)
Polypeptides whose encoding peptides and method for making these peptides and dnas. (1986) (0)
OJ-507 Autoantibodies against Cardiac Troponin I are the Critical Role for Autoimmune Dilated Cardiomyopathy(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese)) (2004) (0)
Table of Contents (1991) (0)
Cancer treating agent (2017) (0)
Tbe D-JH complex is an intennediate to tbe complete immunoglobuUn heavy-chain V-region gene (1983) (0)
[II-2 receptor genes]. (1985) (0)
Gene Expression Patterns Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system (2004) (0)
Lymphocyte Differentiation and Gene Rearrangement (1983) (0)
Immunoglobulin gene diversification by activation-induced cytidine deaminase (AID) through Topoisomerase1 (Top1) (2015) (0)
Immunology of chronic liver diseases (WS-084) Chairpersons: Tetsuo Takehara, Norihiko Watanabe (2010) (0)
SLE and other connective tissue diseases (animal models) (WS-017) Chairpersons: Takayuki Sumida, Sachiko Hirose (2010) (0)
the Lupus-Like Nephritis of NZB/W F1 Mice T Cells and Relieves + PD-1+ Reduces CD4 Anti-Programmed Cell Death 1 Antibody (2010) (0)
during Infection of Primary Cells Requirements for Uracil DNA Glycosylase X4 and R5 HIV-1 Have Distinct Post-entry Microbiology: (2014) (0)
3 MOLECULAR MECHANISM OF IMMUNOGLOBULIN CLASS SWITCH RECOMBINATION (1999) (0)
Comparison of immunoglobulin .GAMMA.1 and .GAMMA.2b chain genes cloned from newborn mouse. Evolutional divergence of intervening sequences and structural basis for recognition of splicing sites.:Evolutional Divergence of Intervening Sequences and Structural Basis for Recognition of Splicing Sites (1979) (0)
Title AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination (2021) (0)
Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. (1980) (0)
FACS analysis of hCD2 and RFP expression in Aid-cre-cd2 and dME-ac-cre B cell-lineage lymphocytes. (2013) (0)
Identiﬁcation of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus (2000) (0)
New chemokine produced by hematopoietic cells and DNA encoding kemokines (1994) (0)
PL 03.01 Serendipities of Acquired Immunity (2017) (0)
Costimulation (PP-102) (2010) (0)
Cloning of mouse immunoglobulin E gene and its location within the heavy chain gene cluster ( IgE hybridoma / nucleotide sequence determination / deletion of heavy chain genes / gene walldng ) (0)
B cell tolerance and autoimmunity. (2000) (0)
Surgical orthodontic treatment to the patient who developed excess anterior open bite during adolescence (2004) (0)
Quantitative assessment of post-graduate orthodontic program in Okayama University (2007) (0)
Nucleetide sequences of gene-segments encoding membrane domains of immunoglobulin y chains (2003) (0)
Science and government. In search of the best grant system. (2005) (0)
Speaker and Affiliation Title of Seminar (2011) (0)
Patents and literature (1986) (0)
Monotherapy model using anti-PD-L1 antibody [Cell number] (2022) (0)
Genetic analysis in a high IgA strain of ddY (HIGA) mice (2002) (0)
Tax Benefit of Foreign Direct Investment (2007) (0)
Recent Developments in Domestic Tax Laws (2007) (0)
Substance specifique a pd-1 humain (2004) (0)
The regulation of cortical neuronal migration by RBP-J (2007) (0)
[Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase]. (1970) (0)

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