Teruo Hideshima
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Philosophy
Teruo Hideshima's Degrees
- PhD Medical Science University of Tokyo
- Doctorate Medicine University of Tokyo
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(Suggest an Edit or Addition)Teruo Hideshima's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A phase 2 study of bortezomib in relapsed, refractory myeloma. (2003) (2631)
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. (2001) (1584)
- Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. (2001) (909)
- Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. (2000) (902)
- Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets (2007) (885)
- NF-κB as a Therapeutic Target in Multiple Myeloma* (2002) (854)
- Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. (2010) (813)
- Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. (2002) (801)
- Molecular sequelae of proteasome inhibition in human multiple myeloma cells (2002) (769)
- The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. (2003) (730)
- Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. (2002) (670)
- A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. (2005) (661)
- Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. (2004) (652)
- Advances in biology of multiple myeloma: clinical applications. (2004) (623)
- Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. (2005) (593)
- Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. (2003) (589)
- Proteasome inhibition as a novel therapeutic target in human cancer. (2005) (570)
- Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. (2004) (570)
- Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications (2001) (544)
- Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. (2012) (521)
- A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. (2006) (511)
- Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma (2001) (505)
- Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. (2002) (493)
- Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications (2002) (491)
- A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. (2012) (466)
- NF-kappa B as a therapeutic target in multiple myeloma. (2002) (464)
- Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. (2007) (453)
- Molecular mechanisms of novel therapeutic approaches for multiple myeloma (2002) (440)
- Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. (2001) (440)
- Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. (2008) (435)
- Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. (2005) (431)
- TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. (2001) (421)
- CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. (2009) (419)
- The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: therapeutic applications (2001) (404)
- Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. (2007) (395)
- Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. (2002) (395)
- Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. (2006) (349)
- Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. (2009) (347)
- Antimyeloma activity of heat shock protein-90 inhibition. (2005) (327)
- Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans. (2013) (322)
- Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application (2005) (317)
- Molecular sequelae of histone deacetylase inhibition in human malignant B cells. (2003) (309)
- Bortezomib mediates antiangiogenesis in multiple myeloma via direct and indirect effects on endothelial cells. (2006) (291)
- Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. (2004) (279)
- Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers. (2003) (268)
- An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection. (1991) (261)
- A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. (2009) (257)
- Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. (2008) (248)
- Mechanism of Action of Proteasome Inhibitors and Deacetylase Inhibitors and the Biological Basis of Synergy in Multiple Myeloma (2011) (245)
- Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. (2003) (244)
- Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma (2015) (242)
- Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. (2009) (239)
- Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. (2003) (238)
- RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS (2014) (235)
- NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. (2003) (226)
- Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. (2006) (224)
- A novel Bcl-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma (2007) (219)
- JNK-dependent Release of Mitochondrial Protein, Smac, during Apoptosis in Multiple Myeloma (MM) Cells* (2003) (215)
- Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells* (2001) (213)
- Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease (2010) (210)
- Novel therapies targeting the myeloma cell and its bone marrow microenvironment. (2001) (209)
- Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. (2003) (203)
- SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. (2009) (203)
- Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma (2008) (202)
- Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. (2009) (202)
- Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. (2007) (201)
- The proteasome and proteasome inhibitors in multiple myeloma (2017) (192)
- SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. (2000) (191)
- Cytokines modulate telomerase activity in a human multiple myeloma cell line. (2002) (189)
- The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma (2006) (189)
- The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo (2009) (189)
- Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. (2008) (187)
- Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma. (2004) (185)
- A phase 2 trial of lenalidomide, bortezomib, and dexamethasone in patients with relapsed and relapsed/refractory myeloma. (2014) (180)
- Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo (2003) (180)
- Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein (2003) (180)
- Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. (2005) (177)
- Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma (2003) (177)
- Identification of genes regulated by Dexamethasone in multiple myeloma cells using oligonucleotide arrays (2002) (170)
- Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications. (2005) (169)
- PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. (2010) (168)
- Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. (2009) (164)
- Proteasome inhibitor therapy in multiple myeloma (2005) (163)
- Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma. (2005) (163)
- 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells (2007) (162)
- VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis. (2004) (162)
- Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. (2004) (161)
- miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/β-catenin/BCL9 pathway. (2014) (159)
- Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. (2002) (158)
- Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. (2003) (157)
- A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. (2005) (156)
- Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma (2010) (155)
- Essential Role of Caveolae in Interleukin-6- and Insulin-like Growth Factor I-triggered Akt-1-mediated Survival of Multiple Myeloma Cells* (2003) (154)
- Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM). (2004) (153)
- Identification of genes modulated in multiple myeloma using genetically identical twin samples. (2004) (151)
- Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. (2005) (145)
- The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. (2007) (144)
- JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells. (2007) (143)
- MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. (2007) (143)
- A novel proteasome inhibitor NPI-0052 as an anticancer therapy (2006) (140)
- Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells. (2003) (140)
- Multiple myeloma: biology of the disease. (2010) (140)
- Thalidomide: emerging role in cancer medicine. (2002) (140)
- Clinical, Radiographic, and Biochemical Characterization of Multiple Myeloma Patients with Osteonecrosis of the Jaw (2008) (139)
- Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. (2004) (138)
- Proteasome inhibition in multiple myeloma: therapeutic implication. (2005) (134)
- The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. (2004) (131)
- Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications. (2004) (130)
- Neutralizing B-Cell–Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model (2007) (129)
- A pivotal role for Mcl-1 in Bortezomib-induced apoptosis (2008) (128)
- The role of the bone marrow microenvironment in the pathophysiology of myeloma and its significance in the development of more effective therapies. (2007) (127)
- The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma. (2002) (127)
- Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. (2003) (126)
- 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. (2002) (125)
- A Novel Role for CCL3 (MIP-1α) in Myeloma-induced Bone Disease via Osteocalcin Downregulation and Inhibition of Osteoblast Function (2011) (125)
- Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti‐myeloma activity in vitro and in vivo (2010) (125)
- Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity. (2004) (123)
- Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. (2011) (123)
- Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma. (2005) (123)
- Bortezomib: proteasome inhibition as an effective anticancer therapy. (2006) (122)
- Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. (2012) (122)
- Histone deacetylase 3 as a novel therapeutic target in multiple myeloma (2014) (120)
- Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. (2003) (119)
- Video-assisted thoracoscopic esophagectomy for esophageal cancer (1999) (119)
- Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. (2003) (118)
- RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells (1999) (117)
- Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). (2006) (116)
- Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. (2009) (115)
- MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo (2006) (114)
- CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. (2003) (113)
- 20 KDa homologous restriction factor of complement resembles T cell activating protein. (1989) (113)
- A High-Affinity Fully Human Anti–IL-6 mAb, 1339, for the Treatment of Multiple Myeloma (2009) (112)
- Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells (2007) (112)
- Proteasome Inhibition in the Treatment of Cancer (2005) (111)
- Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis. (2007) (110)
- Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. (2003) (110)
- AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition (2010) (108)
- FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. (2005) (108)
- p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells (2004) (107)
- Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment (2004) (105)
- Gene expression analysis of B‐lymphoma cells resistant and sensitive to bortezomib * (2006) (104)
- Novel therapeutic approaches for multiple myeloma (2003) (104)
- Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma (2005) (102)
- Targeting NF-kappaB in Waldenstrom macroglobulinemia. (2008) (101)
- High-Dose Zoledronic Acid Impacts Bone Remodeling with Effects on Osteoblastic Lineage and Bone Mechanical Properties (2009) (99)
- Ascorbic acid inhibits antitumor activity of bortezomib in vivo (2009) (98)
- Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia. (2007) (96)
- Novel therapeutic strategies for multiple myeloma. (2015) (96)
- Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma (2016) (93)
- Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma. (2009) (93)
- Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma (2006) (91)
- Bortezomib in the front-line treatment of multiple myeloma (2008) (91)
- Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. (2008) (90)
- The malignant clone and the bone-marrow environment. (2007) (89)
- Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib (2004) (89)
- Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. (2016) (88)
- Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. (2003) (87)
- HDAC Inhibition by LBH589 Affects Phenotype and Function of Human Myeloid Dendritic Cells (2010) (87)
- GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. (2004) (87)
- Bortezomib as an antitumor agent. (2006) (85)
- Novel therapies for multiple myeloma (2003) (85)
- Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma. (2015) (85)
- A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells (2015) (84)
- Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells. (2003) (84)
- Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity. (2013) (83)
- The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival (2015) (83)
- Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells. (2004) (81)
- Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma (2004) (81)
- Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. (2003) (81)
- Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications. (2009) (80)
- Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity (2012) (80)
- Identification and validation of novel therapeutic targets for multiple myeloma. (2005) (80)
- Targeting the Phosphatidylinositol 3-Kinase Pathway in Multiple Myeloma (2007) (78)
- Biologic sequelae of c-Jun NH2-terminal kinase (JNK) activation in multiple myeloma cell lines (2003) (78)
- Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors (2018) (78)
- Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia. (2008) (77)
- The emerging role of novel therapies for the treatment of relapsed myeloma. (2007) (77)
- Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6. (2000) (77)
- Lenalidomide, Bortezomib, and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma: Encouraging Efficacy in High Risk Groups with Updated Results of a Phase I/II Study (2008) (77)
- New Proteasome Inhibitors in Myeloma (2012) (76)
- Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib (2009) (76)
- The use of novel agents in the treatment of relapsed and refractory multiple myeloma (2009) (75)
- MUC1-C drives MYC in multiple myeloma. (2016) (74)
- Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma. (2000) (74)
- TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes. (2004) (74)
- Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. (2003) (73)
- Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma (2011) (71)
- CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines. (2000) (71)
- Emerging Therapies for Multiple Myeloma (2006) (71)
- Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma (2012) (70)
- Proteasome inhibition (2004) (70)
- Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling. (2008) (68)
- Critical Role for Hematopoietic Cell Kinase (Hck)-mediated Phosphorylation of Gab1 and Gab2 Docking Proteins in Interleukin 6-induced Proliferation and Survival of Multiple Myeloma Cells* (2004) (68)
- CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells. (2008) (68)
- Proteasome inhibition in hematologic malignancies (2004) (68)
- Inhibition of p38α MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-XL, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo (2006) (66)
- The number of lymph node metastases influences survival in esophageal cancer (1998) (66)
- MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. (2006) (65)
- Lenalidomide Plus Bortezomib (Rev-Vel) in Relapsed and/or Refractory Multiple Myeloma (MM): Final Results of a Multicenter Phase 1 Trial. (2006) (65)
- In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. (2013) (65)
- KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival (2017) (65)
- Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib. (2009) (64)
- Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. (1999) (64)
- Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. (2014) (64)
- Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma (2009) (64)
- Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway (2005) (63)
- Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo (2009) (62)
- Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells (2003) (61)
- Phase transitions in human IgG solutions. (2013) (59)
- Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a Phase I Multiple Myeloma Research Consortium study (2012) (58)
- SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma. (2005) (58)
- Intracellular Protein Degradation and Its Therapeutic Implications (2005) (58)
- p38 mitogen‐activated protein kinase inhibitor LY2228820 enhances bortezomib‐induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications (2008) (57)
- Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage1 (2000) (57)
- Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma (2015) (57)
- Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide (2011) (57)
- Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment (2008) (56)
- HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications (2017) (56)
- Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341 (2004) (56)
- Histone deacetylase inhibitors in multiple myeloma: from bench to bedside (2016) (55)
- Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. (2007) (55)
- Functional activity of an HIV-1 neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis. (1992) (55)
- Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation (1999) (54)
- Novel biological therapies for the treatment of multiple myeloma. (2005) (54)
- Molecular Motion in Solid State Polymers (1963) (53)
- Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo. (2005) (53)
- Recombinant humanized anti‐CD40 monoclonal antibody triggers autologous antibody‐dependent cell‐mediated cytotoxicity against multiple myeloma cells (2003) (53)
- BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen‐activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth (2007) (52)
- Cytokines and signal transduction. (2005) (51)
- Targeting proteasomes as therapy in multiple myeloma. (2008) (51)
- Significant Biological Role of Sp1 Transactivation in Multiple Myeloma (2011) (50)
- A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity (2018) (50)
- Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma (2015) (50)
- Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma (2018) (50)
- Isolation and characterization of human multiple myeloma cell enriched populations. (2000) (49)
- Small Molecule Multi-Targeted Kinase Inhibitor RGB-286638 Triggers P53-Dependent and -Independent Anti-Multiple Myeloma Activity through Inhibition of Transcriptional CDKs (2013) (48)
- A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells. (2010) (48)
- Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-β inhibitors (2005) (48)
- Proteasome inhibition as a new therapeutic principle in hematological malignancies. (2006) (47)
- The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells (2015) (47)
- Lenalidomide, Bortezomib, and Dexamethasone in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM): Encouraging Response Rates and Tolerability with Correlation of Outcome and Adverse Cytogenetics in a Phase II Study. (2008) (47)
- A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications (2016) (46)
- Protein Arginine Methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in Multiple Myeloma (2017) (46)
- Liposomal carfilzomib nanoparticles effectively target multiple myeloma cells and demonstrate enhanced efficacy in vivo. (2014) (46)
- Novel therapies in the treatment of multiple myeloma. (2009) (45)
- Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma (2007) (43)
- Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling (2019) (42)
- Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. (2006) (41)
- JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications. (2020) (41)
- New insights into the treatment of multiple myeloma with histone deacetylase inhibitors. (2012) (41)
- Multi-Center Phase II Study of Perifosine (KRX-0401) Alone and in Combination with Dexamethasone (dex) for Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM): Promising Activity as Combination Therapy with Manageable Toxicity. (2007) (39)
- The treatment of relapsed and refractory multiple myeloma. (2007) (39)
- A Phase 1 Trial of Lenalidomide (REVLIMID®) with Bortezomib (VELCADE®) in Relapsed and Refractory Multiple Myeloma. (2005) (38)
- A review of lenalidomide in combination with dexamethasone for the treatment of multiple myeloma (2008) (38)
- Current therapeutic uses of lenalidomide in multiple myeloma (2006) (37)
- Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment. (2004) (37)
- Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of b1-integrin and phosphatidylinositol 3-kinase/AKT signaling beta. (2003) (36)
- Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide (2014) (35)
- Targeting proteasome inhibition in hematologic malignancies. (2003) (35)
- Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs (2005) (35)
- Functional significance of novel neurotrophin‐1/B cell‐stimulating factor‐3 (cardiotrophin‐like cytokine) for human myeloma cell growth and survival (2003) (35)
- Lenalidomide in multiple myeloma (2006) (35)
- Lenalidomide, Bortezomib, and Dexamethasone (Rev/Vel/Dex) as Front-Line Therapy for Patients with Multiple Myeloma (MM): Preliminary Results of a Phase 1/2 Study. (2007) (34)
- β-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells (2002) (33)
- 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27 (2004) (32)
- Targeting signalling pathways for the treatment of multiple myeloma (2005) (32)
- A phase 1 study of oral CC5013, an immunomodulatory thalidomide (Thal) derivative, in patients with relapsed and refractory multiple myeloma (MM). (2001) (32)
- Phase I/II Results of a Multicenter Trial of Perifosine (KRX-0401) + Bortezomib in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma Who Were Previously Relapsed from or Refractory to Bortezomib (2008) (32)
- Proteasomal Degradation of Topoisomerase I Is Preceded by c-Jun NH2-Terminal Kinase Activation, Fas Up-Regulation, and Poly(ADP-Ribose) Polymerase Cleavage in SN38-Mediated Cytotoxicity against Multiple Myeloma (2004) (32)
- p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma. (2017) (32)
- Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma. (2002) (32)
- Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways (2020) (31)
- Pathological crystallization of human immunoglobulins (2012) (31)
- Lenalidomide, Bortezomib, and Dexamethasone (Rev/Vel/Dex) in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM): Preliminary Results of a Phase II Study. (2007) (31)
- Retraction: Fatty acid synthase is a novel therapeutic target in multiple myeloma (2008) (31)
- Lenalidomide for the treatment of relapsed and refractory multiple myeloma (2012) (31)
- Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents (2012) (30)
- Phase II Trial of Lenalidomide, Bortezomib, and Dexamethasone In Patients (pts) with Relapsed and Relapsed/Refractory Multiple Myeloma (MM): Updated Efficacy and Safety Data After >2 Years of Follow-up (2010) (30)
- Medroxyprogesterone acetate treatment reduces serum interleukin‐6 levels in patients with metastatic breast carcinoma (1996) (30)
- Expression of HRF20, a regulatory molecule of complement activation, on peripheral blood mononuclear cells. (1990) (30)
- P38 MAPK Inhibition Enhances PS-341 (bortezomib)-Induced Cytotoxicity Against Multiple Myeloma Cells. (2004) (29)
- Histone deacetylase inhibitors in the treatment for multiple myeloma (2013) (29)
- In vitro anti‐myeloma activity of the Aurora kinase inhibitor VE‐465 (2009) (29)
- The power of proteasome inhibition in multiple myeloma (2018) (28)
- Apoptotic Signaling in Multiple Myeloma: Therapeutic Implications (2003) (28)
- The biological significance of histone modifiers in multiple myeloma: clinical applications (2018) (28)
- Biologic impact of proteasome inhibition in multiple myeloma cells--from the aspects of preclinical studies. (2012) (28)
- Proteasome inhibitors as therapeutics. (2005) (28)
- p53 mutations predict non-small cell lung carcinoma response to radiotherapy. (1999) (27)
- Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells. (1999) (27)
- New treatments for multiple myeloma. (2005) (27)
- Relaxation Spectroscopy of the Dielectric β-Relaxation in Poly(n-alkyl methacrylate)s by Absorption–Current Measurements. I. Dielectric Relaxation Spectra for Atactic Polymers (1982) (27)
- Thalidomide in multiple myeloma. (2002) (27)
- Phase I Results of Perifosine (KRX-0401) in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma (MM) (2008) (26)
- PI3K/p110 is a novel therapeutic target in multiple myeloma (2011) (26)
- Novel therapies in MM: from the aspect of preclinical studies (2011) (26)
- β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome–aggresome–autophagosome–lysosome pathway (2012) (26)
- Expression of steroid receptors, Ki-67, and epidermal growth factor receptor in tamoxifen-treated endometrium. (1999) (26)
- Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of β-catenin/TCF pathway (2007) (26)
- Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor, AZD8055, in Multiple Myeloma (2014) (25)
- Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma (2007) (25)
- Telomerase inhibitors as anticancer therapy. (2002) (24)
- Signaling Pathway Mediating Myeloma Cell Growth and Survival (2021) (24)
- Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation. (2020) (23)
- MUC1‐C is a target in lenalidomide resistant multiple myeloma (2017) (23)
- Managing multiple myeloma: the emerging role of novel therapies and adapting combination treatment for higher risk settings (2011) (22)
- The Cyclophilin A-CD147 complex promotes bone marrow colonization of B-cell malignancies: implications for therapy (2015) (22)
- Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status (2016) (22)
- Therapeutic use of immunomodulatory drugs in the treatment of multiple myeloma (2006) (22)
- Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. (2015) (22)
- Preclinical studies of novel targeted therapies. (2007) (22)
- Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells (2014) (21)
- Plasma Cell Tumors (2003) (21)
- Proteasome inhibitor PS-341 inhibits human multiple myeloma cell growth in a murine model. (2001) (21)
- Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells (2006) (21)
- Low Frequency Coupled Oscillator and its Application to High Polymer Study (1953) (21)
- A mouse/human-chimeric bispecific antibody reactive with human carcinoembryonic antigen-expressing cells and human T-lymphocytes. (1996) (20)
- Benign epithelial cyst of the spleen with a high production of carbohydrate antigen 19-9. (1999) (20)
- Realgar nanoparticles versus ATO arsenic compounds induce in vitro and in vivo activity against multiple myeloma (2017) (20)
- Targeting NF-B in Waldenstrom macroglobulinemia (2008) (20)
- Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma (2017) (19)
- Creep of Polymethyl Methacrylate at Low Temperature (1954) (19)
- Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy (2009) (19)
- Multiple relaxation in a- and ?-loss bands of polyethylene (1973) (19)
- HDAC Inhibition by LBH 589 Affects Phenotype and Function of Human Myeloid Dendritic Cells (2013) (19)
- Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model. (2007) (18)
- Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma (2018) (18)
- in patients with multiple myeloma Elevated soluble MUC 1 levels and decreased anti-MUC 1 antibody levels (2000) (18)
- TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity (2013) (18)
- Dynamical Study on the Secondary Anomalous Absorption Region of Polymethyl Methacrylate (1953) (18)
- Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells (2015) (18)
- Detection of chromogranin A mRNA in small cell lung carcinoma using a new, highly sensitive in Situ hybridization method with a non‐radioisotope oligonucleotide probe (1998) (18)
- AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β (2008) (18)
- Novel therapeutic avenues in myeloma: changing the treatment paradigm. (2007) (17)
- Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers. (2001) (17)
- Targeting LAG3/GAL-3 to overcome immunosuppression and enhance anti-tumor immune responses in multiple myeloma (2021) (17)
- Phase I/II Report from a Multicenter Trial of Perifosine (KRX-0401) + Bortezomib in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma Previously Treated with Bortezomib. (2007) (17)
- IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells (2014) (16)
- Proteasome inhibition as a therapeutic strategy for hematologic malignancies (2005) (16)
- In vivo and in vitro cytotoxicity of R‐etodolac with dexamethasone in glucocorticoid‐resistant multiple myeloma cells (2006) (16)
- Induction of differential apoptotic pathways in multiple myeloma cells by class-selective histone deacetylase inhibitors (2014) (15)
- Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation. (2021) (15)
- Comparative study of dielectric, mechanical, and nuclear magnetic relaxations in linear polyethylene. II. Relaxation spectroscopy of the α, β, and γ loss bands with special emphasis on fine structure (1985) (14)
- Perifosine in Combination with Bortezomib and Dexamethasone Extends Progression-Free Survival and Overall Survival in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Bortezombib: Updated Phase I/II Trial Results. (2009) (14)
- Comparative study of dielectric, mechanical, and nuclear magnetic relaxations of linear polyethylene. I. Broad‐line NMR investigation of the fine structure of the α and γ loss bands observed by dielectric and mechanical measurements (1985) (14)
- A Multicenter Phase II Study of Perifosine (KRX-0401) Alone and in Combination with Dexamethasone (Dex) for Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM). (2006) (14)
- Novel targeted agents in the treatment of multiple myeloma. (2014) (14)
- Postoperative chylothorax following partial resection of mediastinal lymphangioma: Report of a case (1995) (14)
- selective HDAC 6 inhibitor , ACY-1215 , in combination with bortezomib in Preclinical activity , pharmacodynamic and pharmacokinetic properties of a (2012) (13)
- RGB 286638, a Novel Multi-Targeted Small Molecule Inhibitor, Induces Multiple Myeloma (MM) Cell Death through Abrogation of CDKDependent and Independent Survival Mechanisms (2008) (13)
- Erratum: Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma (Leukemia (2008) vol. 22 (1925-1932) 10.1038/leu.2008.174) (2008) (13)
- A Multiple Myeloma Research Consortium (MMRC) Multicenter Phase I Trial of Perifosine (KRX-0401) in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma (MM): Updated Results. (2007) (12)
- Recent advances in the treatment of Multiple Myeloma. (2006) (12)
- An update of novel therapeutic approaches for multiple myeloma (2004) (11)
- HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer. (2017) (11)
- High Response Rates and Encouraging Time-to-Event Data with Lenalidomide, Bortezomib, and Dexamethasone in Newly Diagnosed Multiple Myeloma: Final Results of a Phase I/II Study. (2009) (11)
- Emerging drugs in multiple myeloma (2007) (11)
- The potential benefits of participating in early‐phase clinical trials in multiple myeloma: long‐term remission in a patient with relapsed multiple myeloma treated with 90 cycles of lenalidomide and bortezomib (2012) (11)
- Relaxation Spectroscopy of the Dielectric β-Relaxation in Poly(n-alkyl methacrylate)s by Absorption-Current Measurements. II. Dielectric Relaxation Spectrum for Isotactic Poly(methyl methacrylate) (1982) (10)
- PI 3 K / p 110 is a novel therapeutic target in multiple myeloma (2010) (10)
- Effect of the Distribution of Free Volume on the β Relaxation in Poly (Vinylidene Fluoride) (1985) (10)
- The mTOR Inhibitor RAD001 (everolimus) Is Active Against Multiple Myeloma Cells In Vitro and in Vivo. (2004) (10)
- Novel biologically based therapies for multiple myeloma (2002) (10)
- HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer (2017) (10)
- Combination of the mTOR inhibitor Rapamycin and Revlimid ( CC-5013 ) has synergistic activity in Multiple Myeloma (2004) (10)
- Novel biologically based therapeutic strategies in myeloma. (2002) (10)
- Dasatinib (BMS-354825): A Multi-Targeted Kinase Inhibitor with Activity Against Multiple Myeloma. (2005) (10)
- Clinical translation in multiple myeloma: from bench to bedside. (2013) (10)
- CD 40 induces human multiple myeloma cell migration via phosphatidylinositol 3 – kinase / AKT / NF-B signaling (2003) (10)
- Bortezomib in the management of multiple myeloma (2009) (9)
- IPI-504: A Novel hsp90 Inhibitor with In Vitro and In Vivo Anti-Tumor Activity. (2004) (9)
- Panobinostat Inhibits JAK2/STAT3 Pathway in Multiple Myeloma. (2009) (9)
- Selective Inhibition of HDAC6 with a New Prototype Inhibitor (ACY-1215) Overcomes Bortezomib Resistance In Multiple Myeloma (MM) (2010) (9)
- Proteasome inhibitors as therapeutics: Figure 1 (2005) (9)
- Elevated soluble MUC 1 levels and decreased anti-MUC 1 antibody levels in patients with multiple myeloma (2000) (9)
- Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of 1-Integrin and Phosphatidylinositol 3-Kinase / AKT Signaling 1 (2003) (9)
- Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity (2008) (9)
- Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma. (2021) (8)
- Deubiquitylating Enzyme USP-7, a Novel Therapeutic Target in Multiple Myeloma. (2009) (8)
- Lenalidomide and Bortezomib Inhibit Osteoclast Differentiation and Activation in Multiple Myeloma: Clinical Implications. (2006) (8)
- Final Phase I Results of Perifosine In Combination with Lenalidomide and Dexamethasone In Patients with Relapsed or Refractory Multiple Myeloma (MM) (2010) (8)
- LAQ824 is a novel histone deacetylase inhibitor with significant activity against multiple myeloma: Results of a pre-clinical evaluation in vitro and in vivo. (2002) (8)
- Resistance to Proteasome Inhibitors in Multiple Myeloma (2014) (8)
- Anti-Tumor Activity of KOS-953, a Cremophor-Based Formulation of the hsp90 Inhibitor 17-AAG. (2004) (7)
- Nifuroxazide Inhibits STAT3 Function and Shows Potent Anti-Tumor Activity Against Multiple Myeloma. (2006) (7)
- Combination of a Novel Proteasome Inhibitor NPI-0052 and Lenalidomide Trigger in Vivo Synergistic Cytotoxicity in Multiple Myeloma (2008) (7)
- Emerging trends in the clinical use of bortezomib in multiple myeloma. (2005) (7)
- Nature of the Anomalous Shape Change in Loss Permittivity versus Frequency Curve of Polymers above and near the Glass Transition Temperature (1990) (7)
- ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment (2021) (7)
- Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis (2000) (7)
- CD 40 activation mediates p 53-dependent cell cycle regulation in human multiple myeloma cell lines (2000) (7)
- HRF20, a membrane inhibitor of complement attack, does not protect cells from the cytotoxic reaction by lymphokine activated killer cells. (1990) (7)
- Novel Agent Perifosine Enhances Antitumor Activity of Bortezomib, Rituximab and Other Conventional Therapies in Waldenstrom’s Macroglobulinemia. (2006) (6)
- Bortezomib Induces Proliferation of Mesenchymal Progenitor Cells and Promotes Differentiation towards Osteoblastic Lineage. (2006) (6)
- TGF-β Receptor I Kinase Inhibitor Downregulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment. (2004) (6)
- Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma (2008) (6)
- Randomized, placebo‐controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib (2020) (6)
- The Apparent Second-Order Transition of High Polymers with Special Emphasis on its Manifestation in the Mechanical Properties (1959) (6)
- Targeting Bcl-2 as Therapy for Multiple Myeloma. (2005) (6)
- The expression of MDM2 and p53 protein breast carcinoma. (1997) (6)
- beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. (2002) (6)
- Effect of Distribution of Free Volume on Concentration Dependence of Dielectric Relaxation in Water Mixtures with Poly(Ethylene Glycol) and Glucose (1998) (5)
- The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma. (2006) (5)
- Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma. (1996) (5)
- Pharmacodynamic and Pharmacokinetic Properties of a Novel and Selective HDAC6 Inhibitor, ACY-1215, in Combination with Bortezomib in Multiple Myeloma (2011) (5)
- A Novel Orally Available Proteasome Inhibitor NPI-0052 Induces Killing in Multiple Myeloma (MM) Cells Resistant to Conventional and Bortezomib Therapies. (2004) (5)
- Dielectric Relaxations in Poly(γ-n-alkyl L-glutamate) II. Study of Relaxation due to Motion of the Side Chain and that due to Motion of the Main Chain (1986) (5)
- Dielectric Relaxations in Poly(γ-n-alkyl L-glutamate)s I. Study of the Relaxations above Room Temperature Using the Direct-Current Technique (1985) (5)
- Stress Relaxation Study of Fine Structure of γ-Loss Band of Branched Polyethylene (1982) (5)
- Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease (2008) (5)
- Relaxation spectroscopy of poly(vinylidene fluoride) (1984) (5)
- A proto-oncogene BCL 6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells (2010) (5)
- Multiple Myeloma - a New Era of Treatment Strategies (2012) (5)
- Stress Relaxation Study of γ-Loss Band Linear Polyethylene (1977) (5)
- Targeting NAD+ Salvage Pathway Induces Autophagy in Multiple Myeloma Cells (2011) (5)
- BT062, a CD138-Specific Immunoconjugate, Demonstrates Superior In Vivo Anti-Myeloma Efficacy In Combination with Lenalidomide or Bortezomib (2010) (5)
- Biomarker Correlation with Outcomes in Patients with Relapsed or Refractory Multiple Myeloma on a Phase I Study of Everolimus in Combination with Lenalidomide (2011) (4)
- A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models. (2008) (4)
- AZD6244 (ARRY-142886), a Potent and Selective MEK1/2 Inhibitor Blocks the ERK1/2 Signaling Pathway, Inhibits Osteoclast Differentiation and Activation in Multiple Myeloma: Clinical Implications. (2006) (4)
- Identification of a Novel Long Intergenic Noncoding RNA - Linc00936, with Significant Impact on Multiple Myeloma Cell Growth Via mTOR Pathway Inhibition (2015) (4)
- The CXCR4/SDF-1 Axis Regulates Migration and Adhesion in Waldenstrom Macroglobulinemia. (2006) (4)
- The Treatment of Multiple Myeloma Patients Not Eligible for Asct (2010) (4)
- Primary tumor levels of interleukin-6 in relation to tumor burden in human breast-cancer. (1994) (4)
- The Proteasome Inhibitor NPI-0052 in Combination with Bortezomib Induces Antitumor Activity in Waldenstrom Macroglobulinemia. (2006) (4)
- Distribution of Free Volume and Dielectric Relaxation due to Segmental Motion of Amorphous Chains in Chlorinated Poly(ethylene) (1986) (4)
- The PKC- Inhibitor Enzastaurin Inhibits MM Cell Growth, Survival and Migration in the Bone Marrow Microenvironment. (2005) (4)
- Role of Selective HDAC6 Inhibition On Multiple Myeloma Bone Disease (2012) (4)
- The Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor PTK 787 / ZK 222584 Inhibits Growth and Migration of Multiple Myeloma Cells in the Bone Marrow Microenvironment 1 (1998) (4)
- The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells in vitro and in vivo (2008) (4)
- Combination of Nab-Rapamycin and Perifosine Induces Synergistic Cytotoxicity and Antitumor Activity Via Autophagy and Apoptosis in Multiple Myeloma (MM) (2008) (4)
- Immunomodulatory Effects of HDACi in Combination with Checkpoint Blockade and Lenalidomide in the Immunosuppressive Multiple Myeloma Bone Marrow Microenvironment (2017) (4)
- Distinct Dynamic Profiles for NPI-0052-And Bortezomib-Induced Apoptosis in Multiple Myeloma. (2006) (4)
- Mechanical Relaxation of Poly (Vinylidene Fluoride) and Copolymer of Vinylidene Fluoride and Tetrafluoroethylene in α and β Relaxation Regions (1985) (4)
- Novel therapies for multiple myeloma. (2002) (4)
- 2-methoxyestradiol (2ME2) acts directly on tumor cells and in the bone marrow microenvironment to overcome drug resistance in multiple myeloma (MM) cells. (2001) (4)
- A347 Phase I Trial of Perifosine, Lenalidomide, and Dexamethasone in Relapsed or Refractory Myeloma (2009) (4)
- antitumor activity in multiple myeloma Small-molecule inhibition of proteasome and aggresome function induces synergistic (2005) (3)
- Viscoelastic Behavior and Glass Transition of High Polymers (1961) (3)
- Relaxation Spectroscopy of the Mechanical β-Relaxation in Poly(n-alkyl methacrylate)s in Glassy State by Stress Relaxation Measurements (1986) (3)
- Combination of a Novel HDAC 6 Inhibitor ACY-241 with Anti-PD-L1 Antibody Enhances Anti-Tumor Immunity and Cytotoxicity in Multiple Myeloma (2016) (3)
- The Antidiabetic Biguanide Metformin Induces Growth Arrest in Multiple Myeloma Cells in Vitro, overcoming the Effect of Stromal Cells (2008) (3)
- In vitro and in vivo activity of the VEGF receptor inhibitor PAZOPANIB (GW786034) in Multiple Myeloma: Therapeutic implications. (2006) (3)
- CAL-101, a Specific Inhibitor of the p110δ Isoform of Phosphatidylinositide 3-Kinase Induces Cytotoxicity in Multiple Myeloma (MM) (2008) (3)
- Inhibition of ERK1/2 Activity by the MEK1/2 Inhibitor AZD6244 (ARRY-142886) Induces Human Multiple Myeloma Cell Apoptosis in the Bone Marrow Microenvironment: A New Therapeutic Strategy for MM. (2006) (3)
- Preclinical evaluation of a novel and orally active proteasome inhibitor as a therapy in relapsed/refractory multiple myeloma (2005) (3)
- Disruption of DEPTOR/mTORC1/mTORC2 Signaling Cascade Using a Novel Selective mTOR Kinase Inhibitor AZD8055 Results In Growth Arrest and Apoptosis In Multiple Myeloma Cells (2010) (3)
- PR-924, a Selective Inhibitor of the Immunoproteasome Subunit LMP-7 Blocks Multiple Myeloma Cell Growth Both in Vitro and In Vivo. (2009) (3)
- Therapeutics , Targets , and Chemical Biology miR-30-5 p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt / b-Catenin / BCL 9 Pathway (2014) (3)
- The Selective Protein Kinase CB Inhibitor, Enzastaurin, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom’s Macroglobulinemia. (2006) (3)
- Potentiation of cytotoxicity against a CEA positive cell line by the bispecific antibody OH1 using LAK cells from cancer-bearing patients. (1998) (3)
- TAS-117, a Novel Selective Akt Inhibitor Demonstrates Significant Growth Inhibition in Multiple Myeloma Cells in Vitro and in Vivo (2012) (3)
- Selective HDAC6 Inhibition Via ACY-1215, Either Alone or in Combination with Bortezomib, Restores Osteoblast Function and Suppresses Osteoclast Differentiation in Multiple Myeloma (2011) (3)
- FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma (2006) (3)
- Cancer Therapy : Preclinical The Monoclonal Antibody nBT 062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD 138-Positive Multiple Myeloma Cells In vitro and In vivo (2009) (3)
- Potential Therapeutic Role of the Selective Adhesion Molecule (SAM) Inhibitor Natalizumab in Multiple Myeloma. (2009) (3)
- HDAC 6 inhibitor WT 161 downregulates growth factor receptors in breast cancer (2017) (3)
- Targeting IRE1α-XBP1 Pathway Is a Novel Therapeutic Strategy In Multiple Myeloma (2010) (3)
- Receptor activator of nuclear factor-kappa B (RANK) ligand expression: In human multiple myeloma cells. (2001) (3)
- B203 A New Anti-Dkk-1 Antibody Targeting Myeloma Bone Disease (2009) (2)
- Heat shock protein-27 confers drug-resistance in multiple myeloma cells. (2002) (2)
- ESR Study of Gel-Sol Transitions of Poly(L-leucine)-Benzene Solution by Spin-Labeling Technique (1987) (2)
- Perifosine Plus Bortezomib and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Bortezomib: Final Results of a Phase I/II Trial (2011) (2)
- JS-K, a GST-Activated Nitric Oxide Generator, Induces DNA-Double Strand Breaks and Inhibits Growth and Survival of Multiple Myeloma Cells In Vitro and In Vivo. (2006) (2)
- Effect of Nitric Acid-Treatment on γ-Loss Band in Linear Polyethylene (1977) (2)
- Bortezomib induces canonical nuclear factor- (cid:1) B activation in multiple myeloma cells (2009) (2)
- Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma (2021) (2)
- Anti-Myeloma Activity of the Small-Molecule Aurora Kinase Inhibitor VE465. (2006) (2)
- A224 Lenalidomide, Bortezomib, and Dexamethasone Has Notable Activity in High-Risk First-Line Myeloma (2009) (2)
- Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment (2008) (2)
- AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition. (2009) (2)
- Lenalidomide and Bortezomib: Targeting Osteoclastogenesis, Osteoclast Survival Factors, and Bone Remodeling Markers in Multiple Myeloma. (2007) (2)
- Pleiotropic activity of the novel cyclin-dependent kinase inhibitor RGB 286638 predicts therapeutic potential in multiple myeloma (2008) (2)
- Perifosine, an Oral Bioactive Novel Akt Inhibitor, Induces In Vitro and In Vivo Antitumor Activity in Waldenstrom Macroglobulinemia. (2006) (2)
- Dual BCL-2/BCL-XL Inhibitor Pelcitoclax (APG-1252) Overcomes Intrinsic and Acquired Resistance to Venetoclax in Multiple Myeloma Cells (2021) (2)
- Distribution of Free Volume and Dielectric α-Relaxation in Glass-Forming Liquid Mixtures (1995) (2)
- Critical role for Hck-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin-6-induced proliferation and survival of multiple myeloma cells. (2003) (2)
- A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth. (2022) (2)
- Cells : Clinical Implications Antibody , Induces Cytotoxicity in Human Multiple Myeloma Mechanisms by which SGN-40 , a Humanized Anti-CD 40 (2004) (2)
- A new improved technique for placement of a pursestring suture on the edge of the distal part of the rectal stump using a skin stapler for low anterior resection. (1994) (2)
- MLN-8237 (2010) (2)
- Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma (2000) (2)
- Lenalidomide and bortezomib induce osteoclast cytotoxicity and decrease BAFF secretion in osteoclasts in human multiple myeloma: Clinical implications. (2006) (2)
- Targeting NF-kB by Perifosine, Bortezomib and Rituximab in Waldenstrom Macroglobulinemia (WM). (2007) (2)
- Effects of the indazolylpyrimidine GW786034 on angiogenesis and MM cell growth: Therapeutic implications. (2004) (2)
- The Combination of Bortezomib and NPI-0052 Exerts Anti-Tumor Activity in Waldenstrom Macroglobulinemia (WM). (2007) (2)
- AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity (2010) (2)
- HDAC Inhibition by LBH589 Affects Phenotype and Function of Human Dendritic Cells. (2009) (2)
- TH17 Pathway and Associated Pro-Inflammatory Cytokines Promote Immune Dysfunction in Myeloma. (2007) (2)
- Gadolinium Containing Contrast Agent Promotes Multiple Myeloma Cell Growth: Implication for Clinical Use of MRI in Myeloma. (2009) (2)
- Novel hydroxamic acid-derived HDAC inhibitor LBH589 potently activates intrinsic and extrinsic apoptotic pathways, and induces tubulin hyperacetylation in multiple myeloma. (2005) (2)
- Emerging treatments of multiple myeloma; beyond IMIDs and bortezomib (2009) (2)
- Antimyeloma Efficacy of Plitidepsin (Aplidin®): From Bench to the Bedside. (2007) (2)
- Dielectric Relaxation Spectroscopy of Chitin and Related Substances (1992) (2)
- Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo. (2009) (2)
- B483 A Novel Small-Molecule Inhibitor RGB 286638 Induces Apoptosis and Necrosis in Multiple Myeloma (2009) (2)
- The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Potent and Selective Cytotoxicity against CD138 Positive Multiple Myeloma Cells in Vitro and in Vivo. (2008) (2)
- PKC412 Is a Multi-Targeting Kinase Inhibitor with Activity Against Multiple Myeloma In Vitro and In Vivo. (2005) (2)
- Genome-Wide CRISPR-Cas9 Screening Reveals a Role for TRAF2 in Resistance to IMiDs in Multiple Myeloma (2018) (2)
- The Critical Role of HDAC1-IRF4-Pim-2 Axis in Myeloma Cell Growth and Survival: Therapeutic Impacts of Targeting the HDAC1-IRF4-Pim-2 Axis (2018) (2)
- Function and expression of checkpoint inhibitors and immune agonists on immune cells in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM and tumor-specific T lymphocytes. (2017) (2)
- Mitochondria and caspase-independent cell-death triggered by GCS-100, a novel carbohydrate-based therapeutic in multiple myeloma (MM) cells. (2004) (2)
- Blocking HDAC3 in Bone Marrow Stromal Cells Has Direct Anti-Multiple Myeloma Effect and Modulates T Cell Function (2017) (2)
- The PI3K/Akt Pathway Is an Important Regulator of Homing and Adhesion in Waldenstrom’s Macroglobulinemia. (2006) (2)
- Targeting mitochondria to overcome conventional and Bortezomib-resistance in multiple myeloma cells. (2003) (2)
- Mechanisms, biologic sequelae and clinical benefits of bortezomib-induced immunogenic cell death in multiple myeloma (2019) (2)
- Targeting Immune Suppressive Microenvironment By Immune Checkpoint Blockade in Multiple Myeloma (2014) (2)
- Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy (2000) (1)
- Novel Combination Therapies for the Treatment of Relapsed/Refractory Multiple Myeloma: Current Phase I/II Combinations (2009) (1)
- Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma (2022) (1)
- The Small-Molecule VEGF-Receptor Inhibitor Pazopanib (GW786034B) Targets Both Tumor and Endothelial Cells in Multiple Myeloma. (2006) (1)
- Clinical, Radiographic, and Biomarker Characterization of Multiple Myeloma Patients with Bisphosphonate Associated Osteonecrosis of the Jaw. (2006) (1)
- Advances in Brief Functional Interaction between Retinoblastoma Protein and Stress-activated Protein Kinase in Multiple Myeloma Cells 1 (1999) (1)
- Gene expression analysis of tumor cells sensitive and resistant to PS-341 (Bortezomib) treatment: Clinical implications. (2003) (1)
- Nuclear Magnetic and Mechanical Relaxations in the γ-Loss Band of Linear Polyethylene Treated with Fuming Nitric Acid (1984) (1)
- A Novel SIRT1 Activator SIRT1720 Triggers In Vitro and In Vivo Cytotoxicity In Multiple Myeloma Via ATM-Dependent Mechanism (2010) (1)
- Inhibition Of H3K27-Methylome As a Novel Therapeutic Strategy In Multiple Myeloma (2013) (1)
- Nuclear Magnetic and Mechanical Relaxations in the γ-Loss Band of Linear Polyethylene Irradiation with γ-Rays (1984) (1)
- Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma (2012) (1)
- NVP-AEW541: A Selective Small Molecule IGF-1R Tyrosine Kinase Inhibitor Is Active Against Multiple Myeloma and Other Hematologic Neoplasias and Solid Tumors. (2004) (1)
- [Proteasome inhibitor bortezomib as an anticancer drug]. (2006) (1)
- Bcl6 as a Novel Therapeutic Target in Multiple Myeloma (MM). (2009) (1)
- Significant Biological Role of Sp1 Transactivation in Myeloma: Potential Therapeutic Application. (2009) (1)
- beta-Lapachone is safe and effective in Biege-Nude-Xid mouse xenograft model of human plasmacytoma. (2001) (1)
- Interactions of the Mdm2/p53 and Proteasome Pathways: Implications for Combination Strategies to Enhance the Anti-Myeloma Activity of Bortezomib (2008) (1)
- Critical role for Hck-mediated phosphorylation of Gab1 and Gab2 docking proteins in IL-6- induced proliferation and survival of MM cells (2004) (1)
- Expression and Modulation of Carbohydrate-Binding Protein Galectin-3 in Multiple Myeloma Cells by Combined Treatment with GCS-100 and Dexamethasone. (2005) (1)
- synergistic in myeloma cells hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are -tubulin α Aggresome induction by proteasome inhibitor bortezomib and (2013) (1)
- The Role of the ABL1/YAP1/P73 Axis in Prevention of DNA Damage-Mediated Apoptosis in Multiple Myeloma (2012) (1)
- Molecular Profiling of Extramedullary and Medullary Plasmacytomas. (2008) (1)
- A349 Phase I/II Trial of Perifosine + Bortezomib in Rel/Ref MM Patients Previously Treated with Bortezomib (2009) (1)
- The Oncogene MYC Triggers Replicative Stress and DNA Damage In Multiple Myeloma (2013) (1)
- 1 JSK , a GST-activated nitric oxide generator , induces DNA double strand breaks , activates DNA damage response pathways , and induces apoptosis in vitro and in vivo in human multiple myeloma cells (2007) (1)
- In vitro and in vivo proteasome activity profiles of bortezomib and a novel proteasome inhibitor NPI-0052 (2005) (1)
- CYC065, a Potent Derivative of Seliciclib Is Active In Multiple Myeloma In Preclinical Studies (2010) (1)
- B037 CAL-101: A Selective Inhibitor of PI3K p110D for the Treatment of Multiple Myeloma (2009) (1)
- The effect of selective inhibition of HDAC6 with ACY1215 on bortezomib activity in multiple myeloma (MM). (2011) (1)
- Whole-genome bisulfite sequencing identifies HDAC3-mediated DNA methylation in multiple myeloma (2019) (1)
- Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma (2010) (1)
- The Role of B Cell-Activating Factor (BAFF) in the Biology of Multiple Myeloma (MM). (2005) (1)
- Atiprimod (N-N-diethl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) Inhibits Myeloma in Vivo. (2004) (1)
- MLN 120 B , a Novel I K BKinase B Inhibitor , Blocks Multiple Myeloma Cell Growth In vitro and In vivo (2006) (1)
- inhibition myeloma cells via mTORC 1 and extracellular signal-regulated kinase salvage pathway induces autophagy in multiple + Targeting NAD (2012) (1)
- The BAFF Inhibitor AMG523 Blocks Adhesion and Survival of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment: Clinical Implication. (2006) (1)
- Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma (2019) (1)
- Change of Distribution of Free Volume in a Polymer Caused by Crystallization (1999) (1)
- Thalidomide analogue IMiD3 provides T cell co-stimulation through B7-CD28 pathway. (2002) (1)
- DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma (2011) (1)
- Targeting Cyclin D1 in the Treatment of Multiple Myeloma: Preclinical Validation of a Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00. (2006) (1)
- Inhibition Of Myeloid Derived Suppressor Cells (MDSC) In The Multiple Myeloma Bone Marrow Microenvironment (2013) (1)
- Nanoparticle Arsenic Compound Realgar Effectively Targets Myeloma Stem-Like Side Population (2013) (1)
- Pembrolizumab (anti-PD-1) Treatment Increases Anti-Tumor Activities of XBP1/CD138/CS1-Specific Cytotoxic T Lymphocytes Against Multiple Myeloma (2017) (1)
- Histone Deacetylase Inhibitors in Multiple Myeloma (2008) (1)
- Abstract 2530: Antimyeloma activity of a small molecule multi-targeted kinase inhibitor, AT9283, via potent aurora kinase and STAT3 inhibition (2010) (1)
- Endothelial Cells Induce Multiple Myeloma Cell Proliferation Protect Against Conventional and Novel Therapies. (2004) (1)
- Serine/Threonine Kinase STK4 Is a Novel Target in Myeloma (2014) (1)
- Myeloma Patient-Derived Mesenchymal Stem Cells Grown In 3-D Culture Induce Primary Myeloma Cell Proliferation and Resistance To Therapy (2013) (1)
- Effect of the specific P53 stabilizer CBS9106 on multiple myeloma (MM). (2016) (1)
- The monoclonal antibody nBT 062 conjugated to maytansinoids has potent and selective cytotoxicity against CD 138 positive multiple myeloma cells in vitro and in vivo (2008) (1)
- Low Levels of Circulating CS1, a Newly Identified Multiple Myeloma (MM) Antigen for a Novel Humanized HuLuc63 Monoclonal Antibody, Is Detected in MM Patient Sera and Correlates with Active Disease. (2007) (1)
- Serotonin Receptor Antagonists Have an In Vitro and In Vivo Anti-Myeloma Effect That Is Mainly Mediated by Caspase Dependent Apoptosis. (2006) (1)
- JAK-STAT3 Pathway Regulates CD38 Expression on Multiple Myeloma Cells (2018) (1)
- HDAC3 Maintains DNMT1 through Dual Mechanisms in Multiple Myeloma (2016) (1)
- Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma. (2021) (1)
- Abstract B100: Development of fargeted multiple myeloma cancer vaccine and antigen-specific T-cell immunotherapy using novel Immunogenic-engineered heteroclitic BCMA peptides (2019) (1)
- Phenotypic and Functional Effects of Novel Akt Inhibitor Perifosine on Immune System. (2008) (1)
- Requirement of Caspase-8 Versus Caspase-9 during Apoptosis in Multiple Myeloma Cells Induced by Bortezomib- or a Novel Proteasome Inhibitor NPI-0052. (2005) (1)
- Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity (2012) (1)
- PRMT5 inhibitors on the (myeloma) road (2018) (1)
- The In Vivo Activity of Neutralizing B Cell-Activating Factor (BAFF) Antibody in the Treatment of Multiple Myeloma (MM). (2006) (1)
- Anti-Tumor Activity of a Novel Immunosuppressant FTY720 in Multiple Myeloma. (2004) (1)
- Analysis of Chemokine and Adhesion Markers in Waldenstrom Macroglobulinemia. (2006) (1)
- Bortezomib Targets Multiple Myeloma Endothelial Cells. (2004) (1)
- Myeloid Derived Suppressor Cells (MDSCs) Regulate Tumor Growth, Immune Response and Regulatory T Cell (Treg) Development in the Multiple Myeloma Bone Marrow Microenvironment (2012) (1)
- In Vivo Anti-Tumor Activity of Atiprimod on SCID Models of Multiple Myeloma. (2005) (1)
- The Change of Viscosity of Silicone Oils by γ-Irradiation (1958) (1)
- R-Etodolac and a Novel Indole-Pyran Structural Analog, SDX-308, Induce Cytotoxicity and Overcome Drug Resistance in Multiple Myeloma. (2005) (1)
- Reversine: A Chemical Probe Providing Insight into Myeloma Biology and Potential Therapeutic Applications. (2006) (1)
- Non-steroidal anti-inflammatory drug therapy for chronic lymphocytic leukemia (2006) (1)
- JS-K, a GST-Activated Nitric Oxide Generator, Induces Apoptosis and Overcomes In Vitro Drug Resistance in Multiple Myeloma Cells. (2005) (1)
- Aberrant RHAMM Splicing in Multiple Myeloma (MM) and Its Implications for Immunotherapy (2019) (0)
- The proteasome and proteasome inhibitors in multiple myeloma (2017) (0)
- New Therapeutic Strategies in Multiple Myeloma (2012) (0)
- High dose chemotherapy supported by autologous bone marrow transplantation to small cell lung cancer (1995) (0)
- High dose of Zoledronic acid inhibits both osteoclasts and osteoblasts in an In Vivo mouse model (2008) (0)
- Anti-Myeloma Activity of Two Novel N-Substituted and Tetraflourinated Thalidomide Analogues. (2004) (0)
- B357 Targeting Myeloma Bone Disease via Activin A Inhibition (2009) (0)
- Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway. (2010) (0)
- Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma (2011) (0)
- OAB-009: Genome-wide CRISPR interference screen identifies RNA Regulator of Lipogenesis (RROL) as a leading LncRNA dependency in Multiple Myeloma (2021) (0)
- In vivo activity of Atiprimod on SCID models of multiple myeloma (2005) (0)
- Differential oxidative stress responses during 2-methoxyestradiol (2ME2) and dexamthasone (Dex)-induced apoptosis in multiple myeloma (MM) cells. (2002) (0)
- Author Correction: Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma (2022) (0)
- KDM5A reinforces MYC transcriptional program and promotes myeloma cell growth (2019) (0)
- Abstract 5352: Genome-wide CRISPR-cas9 screening identifies KDM6A as a modulator of CD38 expression in multiple myeloma: Therapeutic implications (2022) (0)
- Chapter 2 Resistance to Proteasome Inhibitors in Multiple Myeloma (2017) (0)
- Myeloma Bone Marrow Stromal Cells Detection of Kaposi's Sarcoma Herpesvirus DNA Sequences in Multiple (2013) (0)
- Role of ubiquitin-conjugating enzyme CDC34 in multiple myeloma. (2003) (0)
- against apoptosis VEGF induces MCL-1 upregulation and protects multiple myeloma cells (2013) (0)
- Preclinical Validation of a Clinical Grade Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00 for the Treatment of Multiple Myeloma. (2007) (0)
- Molecular Motions and Related Mechanical Relaxations in Linear Polyethylene Treated with Fuming Nitric Acid (1986) (0)
- [Effect of splenectomy in gastric carcinoma surgery on cell-mediated immunity; evaluation with alteration of peripheral blood lymphocyte subsets]. (1987) (0)
- Where is the “Attention Deficit” in ADHD? Perspectives from Cognitive Neuroscience and Recommendations for Future Research (2007) (0)
- The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 in Multiple Myeloma (2008) (0)
- Rectal carcinoma: Is it able to expect stage and prognosis by colonoscope? (1998) (0)
- Identification a Novel Molecular Mechanism Underlying the Anti-CD38-Based Treatment Resistance in Multiple Myeloma Patients (2022) (0)
- The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer. (1997) (0)
- Effect of Presence of Diluent on Molecular Motion of Polyethylene Single Crystals with and without Surface-Crosslinks (1976) (0)
- Novel Mechanisms Underlying IMiDs Resistance in Multiple Myeloma: Therapeutic Implications (2017) (0)
- Myeloma Resistance and is Well Tolerated in Patients with Relapse Multiple Immunomodulatory Derivative of Thalidomide CC-5013 Overcomes Drug (2013) (0)
- Effect of the Pan-PIM Kinase Inhibitor, AZD1208, Alone and in Combination with Bortezomib in Multiple Myeloma (2014) (0)
- Targeting Ribonucleotide Reductase M1 and M2 in Multiple Myeloma (2016) (0)
- Hsp90 Is Critical for the Regulation of Phenotype and Functionality of Human Dendritic Cells. (2005) (0)
- Enhanced CD138 peptide-specific cytotoxic T lymphocyte activities against breast, colon and pancreatic cancers in combination with pembrolizumab (anti-PD1). (2019) (0)
- Cancer Therapy: Preclinical A High-Affinity Fully Human Anti–IL-6 mAb, 1339, for the Treatment of Multiple Myeloma (2009) (0)
- Role of BAFF in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment. (2005) (0)
- Molecular Characterization of PS-341 (bortezomib) Resistance: Implications for Overcoming Resistance Using Lysophosphatidic Acid Acyltransferase (LPAAT)-β Inhibitors. (2004) (0)
- Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703 (2022) (0)
- CCL3 Impairs Osteoblast Function Via Downregulation of Osteocalcin. (2009) (0)
- Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma (2021) (0)
- Dysfunctions of innate and adaptive immune tumor microenvironment in Waldenström macroglobulinemia (2022) (0)
- The induction of cytotoxicity by a bispecific antibody against CEA positive cell line, in vitro (1996) (0)
- Abstract B09: Exploiting oncogene-induced DNA replicative stress as synthetic lethal approach to target myeloma. (2015) (0)
- Splenic autotransplantation following total gastrectomy with splenectomy for gastric carcinoma. (1985) (0)
- Compositions for treating cancer using the proteasome inhibitor PS-341 (2003) (0)
- Abstract 2004: Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia (2015) (0)
- Scientific section designations: Lymphoid Neoplasia Title: p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma Short title: TP53RK is a novel therapeutic target in myeloma (2016) (0)
- IMW Section B (2009) (0)
- TNF-α Confers Resistance of Myeloma Cells to IMiDs through TRAF2 Degradation (2019) (0)
- BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma (2023) (0)
- Lack of Mcl-1 Confers Resistance to Bortezomid in Multiple Myeloma. (2004) (0)
- Enhanced cytotoxicity of monoclonal antibody SGN-40 and immunomodulatory drug IMiD3 against human multiple myeloma (2004) (0)
- Development of PRPK Directed Phthalimides (2021) (0)
- Halofuginone, an Old Anticoccidosis Drug, Induces Apoptosisin Multiple Myeloma Cells, Associated with Down Regulation of MCL1. (2007) (0)
- Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM) (2011) (0)
- macroglobulinemia The Akt pathway regulates survival and homing in Waldenstrom (2008) (0)
- Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma (2021) (0)
- Molecular Profiling of Extramedullary and Medullary Plasmacytomas Compared to Multiple Myeloma (2010) (0)
- B in Waldenstrom macroglobulinemia κ Targeting NF (2013) (0)
- Targeting Replicative Stress to Treat Hematological Disorders (2015) (0)
- Isothermal Thinning of Crystal Lamella of Polyethylene Observed by NMR Measurement (1975) (0)
- Author Correction: The biological significance of histone modifiers in multiple myeloma: clinical applications (2021) (0)
- Treatment of solid tumors (2006) (0)
- B457 AT7519, a Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma via GSK3B (2009) (0)
- Mcl-1 Fragment Mcl-1(128–350) Induces Inhibition of Multiple Myeloma Cell Proliferation and Apoptosis Via Both Upregulation of C-Jun as Well as Modulation of Its Transcriptional Activity (2008) (0)
- synergistic activity in multiple myeloma Combination of the mTOR inhibitor rapamycin and CC-5013 has (2013) (0)
- Correction: Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma (2019) (0)
- Rational for a Combination of Bortezomib and Doxorubicin in the Treatment of Multiple Myeloma: A Pivotal Role for Mcl-1. (2007) (0)
- P-085: Resistance to immunogenic cell death as a novel mechanism of immune escape in high-risk multiple myeloma (2022) (0)
- In vitro and in vivo antitumor activity of the maytansinoid immunoconjugate BB-10901 (huN901-DM1) on CD56+multiple myeloma cells. (2003) (0)
- Development TACI and Bcma Dual-Antigen Targeted Immunotherapy for Multiple Myeloma (2019) (0)
- Is invasion of lymphatic vessei diagnosed before operation in gastric carcinoma (1998) (0)
- Table 136-3, Classification of Monoclonal Gammopathies (2003) (0)
- malignant B cells Molecular sequelae of histone deacetylase inhibition in human (2013) (0)
- Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma (2022) (0)
- Biology and Therapeutic Targeting of Sp1 Transactivation In Myeloma (2010) (0)
- BIRB796 Inhibits p38 MAPK/Hsp27 Pathway and Enhances Cytotoxicity Triggered by Bortezomib, Hsp90 Inhibitor, and Dexamethasone in Multiple Myeloma. (2006) (0)
- In Vitro Activity of a Novel Small Molecule Cyclin Dependent Kinase Inhibitor, CYC202 (seliciclib or R-Roscovitine), in Multiple Myeloma (MM). (2004) (0)
- The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 Targets Myeloma Cells and Their Bone Marrow Microenvironment. (2007) (0)
- B469 Unraveling the Synergism of Nab-Rapamycin and Perifosine Combination in Multiple Myeloma (2009) (0)
- Sp1 Transcription Factor as a Novel Therapeutic Target in Multiple Myeloma (MM) (2008) (0)
- Up-Regulation of c-Jun contributes to the Induction of Apoptosis by Adaphostin in Human Multiple Myeloma Cells. (2005) (0)
- Clinical statistics of gastric cancer in the second department of surgery, school of medicine, Fukuoka University over the last decade (1995-2004) (2007) (0)
- Clinical implications for optimizing the approach to topoisomerase 1 as a therapeutic target in multiple myeloma (MM). (2003) (0)
- microenvironment migration of multiple myeloma cells in the bone marrow GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and (2013) (0)
- A novel non-peptide and orally active proteasome inhibitor overcomes bortezomib-resistance in multiple myeloma (MM) cells (2005) (0)
- JNK activation and Fas up-regulation precede proteasomal degradation of topoisomerase I in SN38-mediated cytotoxicity against multiple myeloma. (2004) (0)
- Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma. (2006) (0)
- Cytokines in Multiple Myeloma (2007) (0)
- Selective Targeting of Multiple Myeloma By Bcma-Specific Central Memory CD8+ cytotoxic T Lymphocytes: A Potential Immunotherapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders (2018) (0)
- OAB-033: Loss-of-function of GABARAP drives tumor resistance to bortezomib-induced immunogenic cell death in multiple myeloma (2021) (0)
- Biological pathways and in vivo anti-tumor activity induced by atiprimod in multiple myeloma (MM). (2006) (0)
- CCL5 (RANTES) Is Suspected to Be the Key Chemokine to Understand the Bone Pathology of Multiple Myeloma (2008) (0)
- RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma (2020) (0)
- Evaluation of Immune Profile in Patients with Multiple Myeloma Using Cytof Technology (2014) (0)
- Nonspecific cross-reacting antigen 5090 is elevated in patients with gastric cancer (1995) (0)
- well tolerated in patients with relapsed multiple myeloma Immunomodulatory drug CC-5013 overcomes drug resistance and is (2013) (0)
- Purification and analysis of immunosuppressive substance derived from malignant pleural effusion of lung cancer patients (1996) (0)
- Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies (2007) (0)
- Targeting therapy for resistant multiple myeloma with a novel inhibitor of NF-KB, NPI-1387. (2005) (0)
- Heterogeneity of B cell lymphopoiesis in patients with premalignant and active myeloma (2023) (0)
- B026 CS1 Promotes Multiple Myeloma Cell Adhesion, Clonogenic Growth, and Tumorigenicity via c-Maf Mediation (2009) (0)
- synergistic cytotoxicity in multiple myeloma vivo in Combination of proteasome inhibitors bortezomib and NPI-0052 trigger (2012) (0)
- Targeting myeloma metabolisms regulated by HDAC1-IRF4 axis can be a novel therapeutic strategy (2019) (0)
- The role of membrane raft in modulating CD40 signaling, ERK activation and cytokine production in human multiple myeloma cells. (2003) (0)
- Aberrant RHAMM (receptor for hyaluronan-mediated motility) splicing in MM is associated with upregulation of PTBP1/2 (polypyrimidine tract binding protein 1/2): therapeutic implications (2019) (0)
- Targeting Proteinkinase C Alters ER-Stress and b-Catenin Signaling in Multiple Myeloma: Therapeutic Implications. (2007) (0)
- Myeloma Microenvironment Controls T Regulatory Cell Activity: Potential Target for Therapeutic Interventions. (2006) (0)
- Mimicking Myeloma Niche Ex Vivo (2014) (0)
- Role Of Sirtuin-6 In Maintenance Of Genomic Instability In Multiple Myeloma Cells (2013) (0)
- Arginine Methylation Mediated By PRMT5 Has Significant Biological and Clinical Impact in Multiple Myeloma (2016) (0)
- Altered Genomic and Epigenetic Profiling of Myeloma Bone Marrow Stromal Cells Identifies Targets for Current and Future Immunotherapeutic Approaches (2019) (0)
- Biologic impact of proteasome inhibition in MM cells - from the aspects of preclinical studies (2012) (0)
- Akt Inhibitor Perifosine-Induced Cytotoxicity Is Associated with Significant Downregulation of Survivin in Human Multiple Myeloma (MM) Cells. (2006) (0)
- Thalidomide in multiple myeloma in the elderly (2009) (0)
- Pomalidomide for the treatment of relapsed and refractory multiple myeloma (2014) (0)
- P-089: Identification of novel targets in multiple myeloma for “undruggable” RAS/CDK signaling cascade (2021) (0)
- Targeting the Ubiquitin-proteasome System in Multiple Myeloma: Examining the Roots of Success (2015) (0)
- Identification of Novel Antigens with Induced Immune Response in MGUS. (2006) (0)
- Genome-Wide CRISPR-Cas9 Screen Identifies KDM6A As a Modulator of Daratumumab Sensitivity in Multiple Myeloma (2022) (0)
- Delineation of Canonical and Non-Canonical NF-κB Pathways in Multiple Myeloma: Therapeutic Implications. (2007) (0)
- MLN3897, a Novel CCR1 Antagonist, Inhibits Osteoclastogenesis by Blocking Early ERK Activation. (2006) (0)
- Rational Combination Treatment of a Novel Selective mTOR Kinase Inhibitor AZD8055 with IGF-1R Inhibitors in Multiple Myeloma (2012) (0)
- Bcl-2, Mcl-1 and p53 Expression Confer Sensitivity to Bcl-2 Inhibitor ABT-737 in Multiple Myeloma. (2006) (0)
- ANALYSIS OF COLORECTAL CANCERS WITH LIVER METASTASIS (1991) (0)
- relapsed, refractory multiple myeloma Clinical factors predictive of outcome with bortezomib in patients with (2013) (0)
- Preclinical Activities of Bortezomib in MM, the Bone Marrow Microenvironment and Pharmacogenomics (2011) (0)
- Bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic apoptosis in multiple myeloma (MM) cells (2003) (0)
- (LY317615.HCl) novel, orally available small-molecule inhibitor enzastaurin Targeting PKC in multiple myeloma: in vitro and in vivo effects of the (2013) (0)
- Traitement de troubles lies a la degradation de proteines (2006) (0)
- myeloma interaction of tumor and bone marrow accessory cells in multiple Immunomodulatory effects of lenalidomide and pomalidomide on (2012) (0)
- A Novel Acanthoic Acid Analog NPI-1342 Blocks IκB Kinase-α and Trigger In Vitro and In Vivo cytotoxicity in Multiple Myeloma Cells (2011) (0)
- Immunohistologic study on an autotransplanted spleen in man - A case report. (1986) (0)
- B569 Targeting the Sp1 Transcription Factor in Multiple Myeloma (2009) (0)
- Proteasome inhibitors: beyond NFKB inhibition alone and the emerging role of combination therapy in the treatment of multiple myeloma (2009) (0)
- Identification Of Novel Alternative Splice Variants Of Sirtuins In Multiple Myeloma: Therapeutic Implications (2013) (0)
- Sulforaphane and PEITC Augment Activity of Conventional and Novel Anti-Myeloma Drugs (2008) (0)
- Epigenetic Modulation by Vidaza™ induces Apoptosis and Overcomes In Vitro Drug Resistance in Human Multiple Myeloma Cells. (2006) (0)
- Phenotypic and Functional Effects of Novel HDAC Inhibitor LBH589 On Human Lymphocyte Populations. (2009) (0)
- Nuclear Magnetic Resonance Study of Molecular Motions in Poly(γ-n-alkyl L-glutamate)s (1986) (0)
- The Biological Sequelae of Stromal Cell-derived Factor-1 (cid:1) in Multiple Myeloma 1 (2002) (0)
- Perifosine Affects Phenotype and Function of Human Myeloid Dendritic Cells (2010) (0)
- cells in the multiple myeloma microenvironment in humans Tumor-promoting immune-suppressive myeloid-derived suppressor (2013) (0)
- A Novel Real-Time In Vivo Homing Model of Multiple Myeloma. (2006) (0)
- The JAK inhibitor INCB20 induces antiproliferative and apoptotic effects in human myeloma cells in vitro and in vivo (2005) (0)
- A RESECTED CASE OF ADVANCED ESOPHAGEAL CARCINOMA SHOWING A PROMINENT RESPONSE TO NEOADJUVANT CHEMOTHERAPY WITH 5-FU AND LEUCOVORIN (1995) (0)
- An Investigational Novel Orally Bioavailable Proteasome Inhibitor MLN9708/MLN2238 Triggers Cytotoxicity In Multiple Myeloma Cells Via p21- and Caspase-8-Dependent Signaling Pathway (2010) (0)
- Novel Etodolac Analog SDX-308 (CEP-18082) Induces Cytotoxicity in Multiple Myeloma Cells Associated with Inhibition of Wnt/β-Catenin Pathway. (2006) (0)
- Change of Distribution of Free Volume in a Polymer Caused by Cross-Linking (2002) (0)
- Phenotypic and Functional Effects of Perifosine on Dendritic Cells. (2007) (0)
- Caveolin-1 Is Required for VEGF- Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib (Velcade®). (2004) (0)
- therapeutic applications B blockade in multiple myeloma: κ - Biologic sequelae of nuclear factor (2013) (0)
- Clonal Heterogeneity and Immune Tumor Microenvironment in Waldenström Macroglobulinemia (2019) (0)
- Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics (2023) (0)
- Abstract PR04: Exploiting oncogene-induced DNA replicative stress as synthetic lethal approach to target myeloma. (2015) (0)
- Anti-Tumor Activities of XBP1 Antigen-Specific Cytotoxic T Lymphocytes Are Enhanced By HDAC6 Inhibitor ACY241 (2016) (0)
- Optimizing Mechanisms for Induction of Immunogenic Cell Death to Improve Patient Outcome in Multiple Myeloma (2018) (0)
- stromal cells mediated interactions with bone marrow - tumorigenicity via c-maf CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and (2013) (0)
- High-dimensional Clonal Heterogeneity and Immune Landscape in Multiple Myeloma (2019) (0)
- Corrigendum to <'Novel therapeutic strategies for multiple myeloma'> <[Experimental Hematology 2015; 43: 732-741]>. (2021) (0)
- A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment. (2004) (0)
- Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma. (2009) (0)
- Pull-through esophagectomy without thoracotomy in the surgical treatment for carcinoma of the thoracic esophagus. (1985) (0)
- Targeting CCR1 for the Treatment of Osteolytic Bone Disease in Multiple Myeloma. (2007) (0)
- patients with newly diagnosed multiple myeloma Lenalidomide, bortezomib, and dexamethasone combination therapy in (2012) (0)
- MLN120B, a Novel IKBKinase B Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo (2006) (0)
- Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase (2022) (0)
- Alkylphosphocholine Perifosine Inhibits Myeloma Cell Growth While Inducing Myeloid Hyperplasia in a Murine Myeloma Model. (2005) (0)
- The Role of Heat Shock Protein 90 as a Therapeutic Target for Multiple Myeloma (2008) (0)
- The novel, orally available small- molecule PKC inhibitor enzastaurin (LY317615.HCl) in multiple myeloma: in vitro and in vivo effects and therapeutic implications (2007) (0)
- Inter and Intra-Clonal Heterogeneity in Multiple Myeloma and Waldenstrom Macroglobulinemia (2014) (0)
- The Role of Bortezomib in the Treatment of Relapsed and Refractory Multiple Myeloma (2008) (0)
- CCR1 Inhibition Targets Osteoclast-Myeloma Adhesion and Exerts in Vivo Anti-Osteoclast Activity (2008) (0)
- Correction: HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer (2021) (0)
- VEGF Upregulates Mcl-1 Expression and Protects Multiple Myeloma Cells Against Starvation Induced-Apoptosis. (2004) (0)
- Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma (2023) (0)
- B540 The Effect of Insulin-Like Growth Factor-1 in Waldenström Macroglobulinemia (2009) (0)
- inhibiting STAT3 Nifuroxazide inhibits survival of multiple myeloma cells by directly (2013) (0)
- Cancer Therapy : Preclinical Dual Inhibition of Canonical and Noncanonical NFk B Pathways Demonstrates Signi fi cant Antitumor Activities in Multiple Myeloma (2012) (0)
- Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma (2023) (0)
- Other Plasma Cell Dyscrasias (2003) (0)
- Discovery of Prolyl-tRNA Synthetase As a Novel Target in Multiple Myeloma (2021) (0)
- Antitumor Activities Of An Oral Selective HSP90α/β Inhibitor, TAS-116, In Combination With Bortezomib In Multiple Myeloma (2013) (0)
- Molecular Motions and Mechanical Relaxations of Poly(Carbonate) in the Glassy State (1989) (0)
- ROLE OF NITRIC OXIDE IN MODULATING MUCOSAL PERMEABILITY AND MITIGATING BACTERIAL TRANSLOCATION FROM THE RAT COLON (1997) (0)
- Epigenetic modulation by VidazaTM induces apoptosis and overcomes in vitro drug resistance in human multiple myeloma cells. (2007) (0)
- in vivo synergistic cytotoxicity in multiple myeloma Combination of proteasome inhibitors bortezomib and NPI-0052 trigger (2008) (0)
- CCR1 Inhibition Impairs Osteoclast Activity and Interaction with Myeloma Cells. (2006) (0)
- Immmunomodulatory Drug (Revamid) Co-stimulates T cells via The B7-CD28 pathway (2003) (0)
- Erratum (2006) (0)
- Niches Within the Multiple Myeloma Bone Marrow Microenvironment (2007) (0)
- Abstract 642: TRAF2 mediates sensitivity to immunomodulatory drugs via NF-κB and ERK signaling in myeloma cells (2020) (0)
- Expression ofHRF20,a regulatory molecule ofcomplementactivation, on peripheral bloodmononuclear cells (1990) (0)
- High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment (2019) (0)
- Abstract LB193: Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma (2021) (0)
- Hsp90 Is Critical for the Regulation of Human T Lymphocytes and NK Cell Phenotype and Function. (2005) (0)
- Dendritic cells efficiently internalize and process exogenous peptides despite proteasome inhibition. (2002) (0)
- LYMPHOID NEOPLASIA MUC1-C drives MYC in multiple myeloma (2016) (0)
- A CASE OF EARLY GASTRIC CANCER OCCURING IN THE MUCOSA ON AN ABERRANT PANCREAS OF THE STOMACH (1995) (0)
- Monoclonal Antibody–Based Therapies in Human Multiple Myeloma (2009) (0)
- proteasome inhibitor PS-341 resistance in multiple Targeting mitochondria to overcome conventional and (2004) (0)
- Activation of B-Cell Maturation Antigen (BCMA) on Human Multiple Myeloma Cells by a Proliferation-Inducing Ligand (APRIL) Promotes Myeloma Cell Function in the Bone Marrow Microenvironment. (2007) (0)
- Inhibition of Hsp90 Targets Multiple Myeloma Cell Growth, Angiogenesis, and Osteoclastogenesis in the BM Microenvironment. (2007) (0)
- Loss-of-Function of Gabarap Impairs Bortezomib-Induced Anti-Tumor Immunity in Multiple Myeloma: Clinical Application (2019) (0)
- ß-Catenin Is a Novel Marker of the Aggresome and Suggests Disruption of the Proteasome-Aggresome-Autophagasome Pathway in Multiple Myeloma In Vivo. (2006) (0)
- Small Molecule Therapeutics Delineating themTORKinasePathwayUsingaDual TORC 1 / 2 Inhibitor , AZD 8055 , in Multiple Myeloma (2014) (0)
- B454 Mcl-1 Fragment Mcl-1128-350 Induces Inhibition of Multiple Myeloma Cell Proliferation and Apoptosis (2009) (0)
- Histone Deacetylase-6 (HDAC6) Modulates Akt and STAT3 Activity Via Heat Shock Protein (Hsp) 90 in Human Multiple Myeloma (MM) Cells. (2006) (0)
- Myeloma Heterogeneity within Its Complex Immune Ecosystem (2019) (0)
- A CASE REPORT OF BOCHDALEK HERNIA ASSOCIATED WITH GASTRIC VOLVULUS IN AN ADULT (1984) (0)
- Procedes et compositions de traitement du cancer au moyen d'inhibiteurs de la proteasome (2003) (0)
- A new model of plasma cell proliferation (2004) (0)
- Induction of Apoptosis by Didox Via Down-Regulation of Bcl-2 Family Proteins in Multiple Myeloma (MM). (2004) (0)
- In Vivo Effects of Zoledronic Acid on Bone Remodeling. (2007) (0)
- BRD9 Is Essential for Ribosome Biogenesis and the Survival of Multiple Myeloma Cells (2022) (0)
- Multiple Myeloma Cell-Osteoblast Interaction Results in Impaired Bone Formation. (2007) (0)
- Targeting Autophagy to Overcome Resistance to Immunogenic Chemotherapy in High-Risk Multiple Myeloma (2022) (0)
- Dietary Supplement Vitamin C Significantly Abrogates Bortezomib-Induced Multiple Myeloma (MM) Cell Growth Inhibition (2008) (0)
- Author Correction: The biological significance of histone modifiers in multiple myeloma: clinical applications (2018) (0)
- marrow milieu Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone (2013) (0)
- Increased TCF-4 Expression Correlates with Reduced Caspase-3 Induction and Confers Resistance to Bortezomib. (2004) (0)
- The Role of the Bone Marrow Microenvironment in the Pathogenesis of Multiple Myeloma (2007) (0)
- IL-17A-Mediated Notch Signaling in Multiple Myeloma (2014) (0)
- beta-lapachone, a novel topoisomerase I inhibitor, has significant cytotoxicity against multiple myeloma (MM) cell lines and patient cells. (2001) (0)
- Molecular Sequaele of Activin A-Dependent Osteoblast Inhibition in Myeloma. (2009) (0)
- Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2 (2014) (0)
- B341 BAY 73-4506, A Novel Orally Available Multikinase Inhibitor in MM (2009) (0)
- specific cytotoxic T lymphocytes - Ex vivo induction of multiple myeloma (2013) (0)
- Inhibition of fatty acid synthase induces anti-tumor effect in multiple myeloma (2008) (0)
- apoptosis myeloma by induction of caspase-dependent and -independent Honokiol overcomes conventional drug resistance in human multiple (2010) (0)
- Identification and Validation of HLA-A24 XBP1us, XBP1sp, CD138, and CS1 Peptides to Generate Antigens Specific-Cytotoxic T Lymphocytes: Preclinical Basis for Vaccine Therapy in HLA-A24 Patients with Multiple Myeloma and Other Cancers (2016) (0)
- TRAF2 Mediates Sensitivity to Immunomodulatory Drugs in the Bone Marrow Microenvironment (2020) (0)
- antitumor activity in Waldenström macroglobulinemia Protein kinase C inhibitor enzastaurin induces in vitro and in vivo (2008) (0)
- A model for the in vitro and in vivo growth of multiple myeloma in the bone marrow microenvironment. (2001) (0)
- Targeting Src-family kinase activation and downstream molecular events to overcome MM cell growth, survival, and drug-resistance. (2005) (0)
- [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth In vitro and in vivo activity of atiprimod (N-N-diethl-8,8-dipropyl-2-azaspiro (2005) (0)
- Modulation of Signaling Cascades by Inhibitors of Histone Deacetylase and Akt (2009) (0)
- Inhibition of human plasmacytoma cell growth by a novel JAK kinase inhibitor. (2004) (0)
- Targeting IKK Inhibits Multiple Myeloma (MM) Cell Growth in the Bone Marrow Microenvironment. (2004) (0)
- Defining a Murine Model To Study Bone Disease in Multiple Myeloma (MM). (2006) (0)
- SDX-101 Is Cytotoxic and Overcomes Drug Resistance in Multiple Myeloma. (2004) (0)
- CYC202 (seliciclib or R-Roscovitine), a small molecule cyclin dependent kinase inhibitor, overcomes drug resistance via down-regulation of Mcl-1 in multiple myeloma (MM) (2005) (0)
- The unusual presentation of mucinous carcinoma in the colon making preoperative diagnosis difficult: Report of a case (2004) (0)
- Cell Type-Specific Deregulation of Polypyrimidine Tract- Binding Proteins (PTBPs) Drive Aberrant Splicing in Multiple Myeloma (MM) and Acute Myeloid Leukemia (AML) (2018) (0)
- A227 Lenalidomide, Bortezomib, and Dexamethasone Is Active in High-Risk Relapsed/Refractory Myeloma (2009) (0)
- Immunomodulatory Effects of Lenalidomide and Bortezomib on Bone Marrow Stroma Cell and CD4 T Cell Interaction in Multiple Myeloma. (2008) (0)
- 1 Targeting NF-κ B in Waldenstrom Macroglobulinemia (2008) (0)
- p38MAPK Inhibitor LSN2322600 Modulates the Bone Marrow Microenvironment and Inhibits Osteoclastogenesis in Multiple Myeloma. (2006) (0)
- Halofuginone, a Novel Antimyeloma Agent, Upregulates C-Jun, JNK and P-53 Protein in Vitro, and Inhibits Tumor Growth and Improves Survival in in Vivo Multiple Myeloma(MM) Animal Models (2008) (0)
- Antitumor activity of the maytansinoid immunoconjugate B-B4 (B-B4-DM1) against CD138+multiple myeloma cells. (2003) (0)
- A chimeric humanized anti-CD40 antibody renders human multiple myeloma (MM) cells refractory to the mitogenic and protective effects of IL-6 (2003) (0)
- against CD138+ multiple myeloma cells DM1 - Cytotoxic activity of the maytansinoid immunoconjugate B-B4 (2013) (0)
- RFP2 Modulates 20S Proteasome Activity, NF Kappa B Activation, and Tumor Cell Growth in Multiple Myeloma. (2009) (0)
- Didox Induced Apoptosis Occurs by Inhibiting DNA Synthesis and Repair Via Down-Regulation of Ribonucleotide Reductase M1 in Multiple Myeloma (MM). (2005) (0)
- Biologic Sequelae of CDC2 Inhibition in MM. (2007) (0)
- From cell biology to therapy: lenalidomide in relapsed/refractory multiple myeloma (2009) (0)
- Targeting the Protein Degradation Pathway in Multiple Myeloma with Synergistic, Selective Small Molecules. (2005) (0)
- Pathway-Catenin / BCL 9 β Therapeutic Tool by Targeting the Oncogenic Wnt / miR-30-5 p Functions as a Tumor Suppressor and Novel (2014) (0)
- The Tyrosine Kinase Inhibitor Adaphostin (NSC 680410), but Not Imatinib Mesylate, Inhibits Survival and Src Tyrosine Kinase Family- Triggered Signaling Pathways of MM Cells. (2004) (0)
- migration and homing in multiple myeloma dependent - Mechanisms of regulation of CXCR4/SDF-1 (CXCL12) (2013) (0)
- The occurrence of decay accelerating factor(DAF) on peripheral blood mononuclear cells in rheumatoid arthritis. With special reference to a possible etiologic relationship.:—with Special Reference to a Possible Etiologic Relationship— (1990) (0)
- Synthetic Lethal Approaches to Exploit Replicative Stress in Aggressive Myeloma (2014) (0)
- Formation of the Functional Niche in Vitro by Mimicking the Pathophysiological Features of the Bone Marrow Microenvironment in Multiple Myeloma (2012) (0)
- Proteasome inhibition regulates survival and homing in Waldenstrom Macroglobulinemia (WM) (2008) (0)
- B281 Ciliary Proteins and Hedgehog Pathway in Multiple Myeloma (2009) (0)
- Abstract PR13: p53-related protein kinase is a novel prognostic marker and therapeutic target in multiple myeloma (2017) (0)
- Compromised Nuclear Sirtuins Activity Sensitizes BRCA-Proficient multiple Myeloma Cells to DNA Damage Agents (2012) (0)
- Molecular Mechanisms Regulating Resistance to the Akt Inhibitor Perifosine in Waldenstrom’s Macroglobulinemia, the Role of the ERK and PKC Pathways. (2006) (0)
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What Schools Are Affiliated With Teruo Hideshima?
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