Theo Wallimann
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Swiss biologist
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Biology
Theo Wallimann's Degrees
- Bachelors Biology University of Zurich
- Masters Molecular Biology University of Zurich
- PhD Cell Biology ETH Zurich
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Why Is Theo Wallimann Influential?
(Suggest an Edit or Addition)According to Wikipedia, Theo Wallimann is a Swiss biologist who was research group leader and Adjunct-Professor at the Institute of Cell Biology ETH Zurich and later at the Institute of Molecular Health Science at the ETH Zurich at the Biology Department, of the ETH Zurich, Switzerland.
Theo Wallimann's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. (1992) (1933)
- LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade (2003) (1654)
- Mitochondrial creatine kinase in human health and disease. (2006) (552)
- The creatine kinase system and pleiotropic effects of creatine (2011) (543)
- Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase* (2006) (473)
- Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism. (1992) (419)
- Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491* (2006) (339)
- Functions and effects of creatine in the central nervous system (2008) (318)
- New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. (2006) (317)
- Creatine kinase in non-muscle tissues and cells (1994) (312)
- Structure of mitochondrial creatine kinase (1996) (268)
- AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits (2006) (267)
- PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis (2010) (262)
- Cardiac system bioenergetics: metabolic basis of the Frank‐Starling law (2006) (244)
- The role of creatine kinase in inhibition of mitochondrial permeability transition (1997) (240)
- Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology (1998) (238)
- Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis* (2003) (232)
- Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β‐Amyloid in Rat Hippocampal Neurons (2000) (226)
- A protein that binds specifically to the M-line of skeletal muscle is identified as the muscle form of creatine kinase. (1973) (224)
- Inhibition of the Mitochondrial Permeability Transition by Creatine Kinase Substrates (2003) (211)
- Muscle-type MM creatine kinase is specifically bound to sarcoplasmic reticulum and can support Ca2+ uptake and regulate local ATP/ADP ratios. (1990) (207)
- Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation* (1998) (200)
- Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism (2008) (190)
- Function of M-line-bound creatine kinase as intramyofibrillar ATP regenerator at the receiving end of the phosphorylcreatine shuttle in muscle. (1984) (178)
- Functional aspects of creatine kinase in brain. (1993) (165)
- Direct Evidence for the Control of Mitochondrial Respiration by Mitochondrial Creatine Kinase in Oxidative Muscle Cells in Situ * (2000) (158)
- Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply. (2005) (152)
- Native mitochondrial creatine kinase forms octameric structures. I. Isolation of two interconvertible mitochondrial creatine kinase forms, dimeric and octameric mitochondrial creatine kinase: characterization, localization, and structure-function relationships. (1988) (147)
- Downregulation of the Na(+)-creatine cotransporter in failing human myocardium and in experimental heart failure. (1999) (145)
- Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle (1998) (144)
- Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. (2003) (144)
- Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore (1998) (141)
- The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition (1998) (136)
- Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. (1996) (133)
- Further characterization of contact sites from mitochondria of different tissues: topology of peripheral kinases. (1989) (132)
- Hair Bundles Are Specialized for ATP Delivery via Creatine Kinase (2007) (128)
- Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells (1998) (127)
- Localization of creatine kinase isoenzymes in myofibrils. II. Chicken heart muscle (1977) (124)
- Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT, GAMT and CT1 (2005) (122)
- Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke (2007) (122)
- Creatine supplementation reduces skeletal muscle degeneration and enhances mitochondrial function in mdx mice (2002) (121)
- Bioenergetics: Dissecting the role of creatine kinase (1994) (119)
- Octamers of Mitochondrial Creatine Kinase Isoenzymes Differ in Stability and Membrane Binding* (2000) (118)
- Electron microscopy of scallop myosin. Location of regulatory light chains. (1983) (117)
- Mitochondrial creatine kinase mediates contact formation between mitochondrial membranes. (1991) (115)
- Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart (2005) (115)
- Localization and Function of M-Line-Bound Creatine Kinase (1985) (114)
- The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes, and Focal Creatine Deposits (2006) (113)
- Creatine kinase: the reactive cysteine is required for synergism but is nonessential for catalysis. (1993) (111)
- Downregulation of the Na+-creatine cotransporter in experimental and in human heart failure (1999) (109)
- Mitochondrial Creatine Kinase in Contact Sites: Interaction with Porin and Adenine Nucleotide Translocase, Role in Permeability Transition and Sensitivity to Oxidative Damage (2001) (109)
- Functional aspects of the X-ray structure of mitochondrial creatine kinase: A molecular physiology approach (1998) (103)
- Mitochondrial Creatine Kinase and Mitochondrial Outer Membrane Porin Show a Direct Interaction That Is Modulated by Calcium* (2001) (101)
- Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. (2003) (98)
- Mitochondrial creatine kinase: a major constituent of pathological inclusions seen in mitochondrial myopathies. (1994) (97)
- In vitro complex formation between the octamer of mitochondrial creatine kinase and porin. (1994) (97)
- 'Hot spots' of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus. (1996) (96)
- Isoenzyme-Specific Interaction of Muscle-Type Creatine Kinase with the Sarcomeric M-Line Is Mediated by Nh2-Terminal Lysine Charge-Clamps (2000) (93)
- Structural Properties of AMP-activated Protein Kinase (2008) (92)
- Metabolic Compartmentation – A System Level Property of Muscle Cells (2008) (92)
- Neuroprotection of Creatine Supplementation in Neonatal Rats with Transient Cerebral Hypoxia-Ischemia (2003) (90)
- Cardiolipin clusters and membrane domain formation induced by mitochondrial proteins. (2007) (89)
- Human, rat and chicken small intestinal Na+‐Cl−‐creatine transporter: functional, molecular characterization and localization (2002) (87)
- Crystal structure of brain‐type creatine kinase at 1.41 Å resolution (2008) (86)
- Sequence homology and structure predictions of the creatine kinase isoenzymes (1994) (86)
- The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo. (2005) (85)
- The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation (2007) (84)
- Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle (1977) (84)
- Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. (2005) (83)
- Location and regulation of octameric mitochondrial creatine kinase in the contact sites. (1991) (82)
- Alterations in myocardial energy metabolism induced by the anti-cancer drug doxorubicin. (2006) (81)
- Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane. (2005) (81)
- Crystal structure of human ubiquitous mitochondrial creatine kinase (2000) (80)
- A molecular approach to the concerted action of kinases involved in energy homoeostasis. (2001) (80)
- Creatine transporters: A reappraisal (2004) (79)
- Creatine metabolism and the consequences of creatine depletion in muscle (1994) (78)
- Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes. (2007) (77)
- Localization and function of M-line-bound creatine kinase. M-band model and creatine phosphate shuttle. (1985) (77)
- Creatine kinase and creatine transporter in normal, wounded, and diseased skin. (2002) (75)
- Native mitochondrial creatine kinase forms octameric structures. II. Characterization of dimers and octamers by ultracentrifugation, direct mass measurements by scanning transmission electron microscopy, and image analysis of single mitochondrial creatine kinase octamers. (1988) (74)
- The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. (2007) (73)
- Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue (2005) (73)
- Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase (1991) (73)
- Mitochondrial creatine kinase from cardiac muscle and brain are two distinct isoenzymes but both form octameric molecules. (1988) (73)
- Multiple interference of anthracyclines with mitochondrial creatine kinases: preferential damage of the cardiac isoenzyme and its implications for drug cardiotoxicity. (2002) (72)
- Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands (2006) (71)
- High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in photoreceptor cells. (1986) (70)
- C-terminal Lysines Determine Phospholipid Interaction of Sarcomeric Mitochondrial Creatine Kinase* (2004) (69)
- Creatine transporter and mitochondrial creatine kinase protein content in myopathies (2001) (67)
- Differential Effects of Peroxynitrite on Human Mitochondrial Creatine Kinase Isoenzymes (2003) (66)
- Structural changes of creatine kinase upon substrate binding. (1998) (65)
- Light-chain movement and regulation in scallop myosin (1983) (65)
- Functional studies with the octameric and dimeric form of mitochondrial creatine kinase. Differential pH-dependent association of the two oligomeric forms with the inner mitochondrial membrane. (1990) (65)
- Crystallization of the human, mitochondrial voltage-dependent anion-selective channel in the presence of phospholipids. (1999) (64)
- III-2 CREATINE KINASE IN NON-MUSCLE TISSUES AND CELLS (1994) (64)
- Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice. (2002) (64)
- Rapid Suppression of Mitochondrial Permeability Transition by Methylglyoxal (2003) (63)
- Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. (2010) (63)
- Mitochondrial creatine kinase from chicken brain. Purification, biophysical characterization, and generation of heterodimeric and heterooctameric molecules with subunits of other creatine kinase isoenzymes. (1990) (63)
- Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. (2003) (63)
- Coupling of creatine kinase to glycolytic enzymes at the sarcomeric I-band of skeletal muscle: a biochemical study in situ (2004) (61)
- Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse (2009) (61)
- Creatine Supplementation Improves Dopaminergic Cell Survival and Protects against MPP+ Toxicity in an Organotypic Tissue Culture System (2005) (60)
- Protective effects of oral creatine supplementation on spinal cord injury in rats (2002) (59)
- Phosphocreatine Interacts with Phospholipids, Affects Membrane Properties and Exerts Membrane-Protective Effects (2012) (59)
- Monovalent antibodies against MM-creatine kinase remove the M line from myofibrils. (1978) (59)
- Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK). (1999) (59)
- Distinct tissue specific mitochondrial creatine kinases from chicken brain and striated muscle with a conserved CK framework. (1988) (58)
- In situ compartmentation of creatine kinase in intact sarcomeric muscle: The acto-myosin overlap zone as a molecular sieve (1992) (58)
- Effects of creatine treatment on survival and differentiation of GABA‐ergic neurons in cultured striatal tissue (2005) (57)
- An increase in the myocardial PCr/ATP ratio in GLUT4 null mice (2002) (57)
- Brain-type creatine kinase in photoreceptor cell outer segments: role of a phosphocreatine circuit in outer segment energy metabolism and phototransduction. (1993) (56)
- The tryptophan residues of mitochondrial creatine kinase: Roles of Trp‐223, Trp‐206, and Trp‐264 in active‐site and quaternary structure formation (1994) (56)
- Subcellular compartmentation of creatine kinase isoenzymes, regulation of CK and octameric structure of mitochondrial CK: important aspects of the phosphoryl-creatine circuit. (1989) (56)
- Octamer-dimer transitions of mitochondrial creatine kinase in heart disease. (1999) (56)
- Phosphorylation of chicken brain‐type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo (1990) (55)
- Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency (2008) (54)
- Structure of the mitochondrial creatine kinase octamer: high-resolution shadowing and image averaging of single molecules and formation of linear filaments under specific staining conditions (1991) (53)
- Creatine and creatine kinase in health and disease--a bright future ahead? (2007) (53)
- Divergent Enzyme Kinetics and Structural Properties of the Two Human Mitochondrial Creatine Kinase Isoenzymes (2000) (53)
- Functional maturation of creatine kinase in rat brain. (1993) (53)
- Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans (2003) (52)
- Equilibration and exchange of fluorescently labeled molecules in skinned skeletal muscle fibers visualized by confocal microscopy. (1995) (52)
- Multiple-state equilibrium unfolding of guanidino kinases. (1995) (51)
- Creatine kinase: An enzyme with a central role in cellular energy metabolism (1998) (51)
- A short review on creatine–creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy (2012) (51)
- Heart C-protein is transiently expressed during skeletal muscle development in the embryo, but persists in cultured myogenic cells. (1985) (50)
- Creatine transporter protein content, localization, and gene expression in rat skeletal muscle. (2001) (50)
- Stimulation of Mitochondrial Gene Expression and Proliferation of Mitochondria Following Impairment of Cellular Energy Transfer by Inhibition of the Phosphocreatine Circuit in Rat Hearts (1999) (50)
- Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: Implications for cellular function and mitochondrial structure (1998) (48)
- Differentiation in cultures derived from embryonic chicken muscle. II. Phosphorylase histochemistry and fluorescent antibody staining for creatin kinase and aldolase. (1976) (48)
- Functional Expression of Phosphagen Kinase Systems Confers Resistance to Transient Stresses in Saccharomyces cerevisiae by Buffering the ATP Pool* (2002) (48)
- Subcellular localization of creatine kinase in Torpedo electrocytes: association with acetylcholine receptor-rich membranes (1985) (47)
- Differential expression and localization of brain-type and mitochondrial creatine kinase isoenzymes during development of the chicken retina: Mi-CK as a marker for differentiation of photoreceptor cells. (1991) (47)
- Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma (2008) (46)
- Why is creatine kinase a dimer? Evidence for cooperativity between the two subunits. (2000) (45)
- Metabolic support of Na+ pump in apically permeabilized A6 kidney cell epithelia: role of creatine kinase. (1997) (45)
- Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation (2015) (45)
- Novel staining pattern of skeletal muscle M-lines upon incubation with antibodies against MM-creatine kinase (1983) (44)
- Membrane-binding and lipid vesicle cross-linking kinetics of the mitochondrial creatine kinase octamer. (1996) (44)
- The importance of the outer mitochondrial compartment in regulation of energy metabolism (1994) (44)
- Interaction of mitochondrial creatine kinase with model membranes A monolayer study (1991) (44)
- Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase (1994) (44)
- Expression of active octameric chicken cardiac mitochondrial creatine kinase in Escherichia coli. (1992) (44)
- Reduced creatine-stimulated respiration in doxorubicin challenged mitochondria: particular sensitivity of the heart. (2007) (43)
- The N-terminal heptapeptide of mitochondrial creatine kinase is important for octamerization. (1994) (42)
- An immunological approach to myosin light-chain function in thick filament linked regulation. 2. Effects of anti-scallop myosin light-chain antibodies. Possible regulatory role for the essential light chain. (1981) (42)
- New candidate targets of AMP-activated protein kinase in murine brain revealed by a novel multidimensional substrate-screen for protein kinases. (2007) (42)
- Re-evaluation of the structure and physiological function of guanidino kinases in fruitfly (Drosophila), sea urchin (Psammechinus miliaris) and man. (1995) (41)
- Novel thick filament protein of chicken pectoralis muscle: the 86 kd protein. II. Distribution and localization. (1985) (40)
- Crystalline mitochondrial inclusion bodies isolated from creatine depleted rat soleus muscle. (1997) (40)
- Creatine kinase isoenzymes in spermatozoa (1986) (40)
- Identification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa. (1996) (40)
- Molecular System Bioenergics of the Heart: Experimental Studies of Metabolic Compartmentation and Energy Fluxes versus Computer Modeling † (2011) (39)
- Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer. A fluorescence study. (1993) (39)
- Activation of sea-urchin sperm motility is accompanied by an increase in the creatine kinase exchange flux. (1997) (39)
- A Quantitative Approach to Membrane Binding of Human Ubiquitous Mitochondrial Creatine Kinase Using Surface Plasmon Resonance (2000) (39)
- In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog. (1997) (39)
- Effects of N-linked glycosylation on the creatine transporter. (2006) (39)
- Myofibrillar interaction of cytosolic creatine kinase (CK) isoenzymes: allocation of N-terminal binding epitope in MM-CK and BB-CK. (1998) (38)
- The role of contact sites between inner and outer mitochondrial membrane in energy transfer. (1990) (38)
- Novel thick filament protein of chicken pectoralis muscle: the 86 kd protein. I. Purification and characterization. (1985) (38)
- Functions of Creatine Kinase Isoenzymes in Spermatozoa (1997) (37)
- Regulatory and essential light-chain interactions in scallop myosin. II. Photochemical cross-linking of regulatory and essential light-chains by heterobifunctional reagents. (1982) (36)
- Enhancement of human sperm motility and velocity in vitro: effects of calcium and creatine phosphate**Presented in part at the Forty-First Annual Meeting of The American Fertility Society, Chicago, Illinois, September 27 to October 2, 1985. (1986) (36)
- Dual electron microscopic localization of mitochondrial creatine kinase in brain mitochondria. (1994) (36)
- Creatine and Creatine Kinase in Health and Disease: A Bright Future Ahead? (2007) (35)
- Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells (2008) (34)
- Limited proteolysis of creatine kinase. Implications for three-dimensional structure and for conformational substrates. (1993) (34)
- Metabolite Channeling: Creatine Kinase Microcompartments (2004) (34)
- A conserved negatively charged cluster in the active site of creatine kinase is critical for enzymatic activity. (2000) (33)
- An immunological approach to myosin light-chain function in thick filament linked regulation. 1. Characterization, specificity, and cross-reactivity of anti-scallop myosin heavy- and light-chain antibodies by competitive, solid-phase radioimmunoassay. (1981) (33)
- Novel Mitochondrial Creatine Transport Activity (2002) (33)
- Crystallization of mitochondrial creatine kinase. Growing of large protein crystals and electron microscopic investigation of microcrystals consisting of octamers. (1991) (33)
- Origin of leg musculature during Drosophila metamorphosis. (1972) (32)
- Functional aspects of creatine kinase isoenzymes in endothelial cells. (2001) (31)
- Properties of arginine kinase from Drosophila melanogaster. (1973) (31)
- Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation. (2002) (30)
- Creatine kinase activity in the Torpedo electrocyte and in the nonreceptor, peripheral v proteins from acetylcholine receptor-rich membranes. (1983) (29)
- Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli (2003) (28)
- Myofibrillar M-band proteins in rat skeletal muscles during development (2004) (28)
- Crystallization of mitochondrial creatine kinase on negatively charged lipid layers. (1994) (28)
- Homo-oligomerization and Activation of AMP-activated Protein Kinase Are Mediated by the Kinase Domain αG-Helix* (2009) (28)
- Creatine treatment promotes differentiation of GABA‐ergic neuronal precursors in cultured fetal rat spinal cord (2007) (27)
- 31P-NMR-measured creatine kinase reaction flux in muscle: a caveat! (1996) (27)
- New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle. (2002) (26)
- Regulatory and essential light-chain interactions in scallop myosin. I. Protection of essential light-chain thiol groups by regulatory light-chains. (1982) (26)
- Changes of creatine kinase structure upon ligand binding as seen by small-angle scattering☆ (1996) (25)
- ATP binding site of mitochondrial creatine kinase (1990) (25)
- Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins (2006) (25)
- Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology (2007) (25)
- Introduction--creatine: cheap ergogenic supplement with great potential for health and disease. (2007) (24)
- Co-expression of LKB1, MO25α and STRADα in bacteria yield the functional and active heterotrimeric complex (2007) (24)
- Hodgkin disease‐derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis (2001) (24)
- Dimer-dimer interactions in octameric mitochondrial creatine kinase. (1995) (24)
- Isoenzyme-specific localization of M-line bound creatine kinase in myogenic cells (1983) (23)
- Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients. (2017) (23)
- Further characterization of the structural and functional properties of the cross-linked complex between F-actin and myosin S-1. (1985) (23)
- The active site histidines of creatine kinase. A critical role of His 61 situated on a flexible loop (1997) (22)
- Reconstitution of active octameric mitochondrial creatine kinase from two genetically engineered fragments (1996) (22)
- Tracking and quantification of 32P-labeled phosphopeptides in liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry. (2009) (22)
- II-1 THE IMPORTANCE OF THE OUTER MITOCHONDRIAL COMPARTMENT IN REGULATION OF ENERGY METABOLISM (1994) (22)
- The in vitro kinetics of mitochondrial and cytosolic creatine kinase determined by saturation transfer 31P-NMR. (1996) (22)
- Autophosphorylation of creatine kinase: characterization and identification of a specifically phosphorylated peptide. (1995) (22)
- Functional differences between dimeric and octameric mitochondrial creatine kinase. (1995) (21)
- Melting of myosin rod as revealed by electron microscopy. II. Effects of temperature and pH on length and stability of myosin rod and its fragments. (1986) (21)
- Analysis of creatine kinase isozymes during muscle differentiation. (1983) (20)
- Two different B‐type creatine kinase subunits dimerize in a tissue‐specific manner (1990) (20)
- The subcellular compartmentation of creatine kinase isozymes as a precondition for a proposed phosphoryl-creatine circuit. (1990) (20)
- Metabolite channelling in aerobic energy metabolism. (1992) (20)
- Effects of creatine supplementation in cystic fibrosis: results of a pilot study. (2003) (19)
- Creatine: a miserable life without it (2016) (19)
- A Method for Quantitative Measurement of Mitochondrial Creatine Kinase in Human Skeletal Muscle (1992) (18)
- Isoenzyme-directed selection and characterization of anti-creatine kinase single chain Fv antibodies from a human phage display library. (2002) (18)
- Creatine promotes the GABAergic phenotype in human fetal spinal cord cultures (2007) (18)
- The interaction of skeletal myosin subfragment 1 with the polyanion, heparin. (1984) (18)
- Effect of okadaic acid on protein phosphorylation patterns of chicken myogenic cells with special reference to creatine kinase (1993) (18)
- Purification of brain-type creatine kinase (B-CK) from several tissues of the chicken: B-CK subspecies. (1989) (18)
- LOCALIZATION OF CREATINE KINASE ISOZYMES IN MUSCLE CELLS: PHYSIOLOGICAL SIGNIFICANCE (1975) (17)
- Isolation and characterization of acetylcholine receptor membrane-associated (nonreceptor v2-protein) and soluble electrocyte creatine kinases. (1985) (17)
- Mutation of conserved active-site threonine residues in creatine kinase affects autophosphorylation and enzyme kinetics. (2002) (17)
- The mitochondrial ATP/ADP carrier: interaction with detergents and purification by a novel procedure. (1994) (17)
- Selective labelling and inactivation of creatine kinase isoenzymes by the thyroid hormone derivative N-bromoacetyl-3,3',5-tri-iodo-L-thyronine. (1993) (17)
- Development and performance of an enzyme immunoassay to detect creatine kinase isoenzyme MB activity using anti-mitochondrial creatine kinase monoclonal antibodies (2009) (17)
- A versatile multidimensional protein purification system with full internet remote control based on a standard HPLC system. (2009) (15)
- Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants. (2004) (15)
- Vacuolar morphology and cell cycle distribution are modified by leucine limitation in auxotrophic Saccharomyces cerevisiae (2000) (15)
- Mitochondrial intermembrane inclusion bodies: The common denominator between human mitochondrial myopathies and creatine depletion due to impairment of cellular energetics (2004) (14)
- Brain ATP Metabolism in Hypoxia Resistant Mice Fed Guanidinopropionic Acid (1998) (14)
- Unshadowed myosin molecules: STEM mass‐maps of myosin heads. (1984) (14)
- Separation of mitochondrial creatine kinase (MiMi-CK) from cytosolic creatine kinase isoenzymes by Cibachrome-Blue affinity chromatography. (1985) (14)
- Brain-type creatine kinase BB-CK interacts with the Golgi Matrix Protein GM130 in early prophase (2007) (13)
- The extended, dynamic mitochondrial reticulum in skeletal muscle and the creatine kinase (CK)/phosphocreatine (PCr) shuttle are working hand in hand for optimal energy provision (2015) (13)
- Crystallization and preliminary X-ray analysis of two different forms of mitochondrial creatine kinase from chicken cardiac muscle. (1990) (12)
- Nucleotide binding to creatine kinase: an isothermal titration microcalorimetry study (1999) (12)
- System Analysis of Cardiac Energetics–Excitation–Contraction Coupling: Integration of Mitochondrial Respiration, Phosphotransfer Pathways, Metabolic Pacing, and Substrate Supply in the Heart (2007) (12)
- MITOCHONDRIAL CREATINE KINASE (1997) (12)
- Macroenzyme Creatine Kinase (Ck) Type 2 in HIV-Infected Patients is Significantly Associated with Tdf and Consists of Ubiquitous Mitochondrial Ck (2006) (12)
- Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures (2006) (12)
- Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis. (2020) (11)
- Mitochondrial intermembrane inclusion bodies: the common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics. (1997) (11)
- Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling (2014) (11)
- The structure of mitochondrial creatine kinase and its membrane binding properties (2004) (11)
- The isoenzyme-diagnostic regions of muscle-type creatine kinase, the M-260 and M-300 box, are not responsible for its binding to the myofibrillar M-band. (1998) (11)
- Expressing creatine kinase in transgenic tobacco – a first step towards introducing an energy buffering system in plants (2002) (10)
- Localization of reactive cysteine residues by maleidoyl undecagold in the mitochondrial creatine kinase octamer. (1995) (9)
- Signaling by AMP‐activated Protein Kinase (2007) (9)
- Co-expression of LKB1, MO25alpha and STRADalpha in bacteria yield the functional and active heterotrimeric complex. (2007) (9)
- Shadowing of elongated helical molecules (myosin, tropomyosin, collagen, and DNA) yields regular molecule-dependent heavy metal grain patterns. (1984) (9)
- Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial (2021) (8)
- Mutation of cis-proline 207 in mitochondrial creatine kinase to alanine leads to increased acid stability. (1998) (8)
- Bt Toxin: Assessing GM Strategies (2000) (7)
- Creatine kinases: a cornerstone for structural research in the phosphagen kinase family (2010) (7)
- Health assessment of creatine as a dietary supplement. (2001) (6)
- Functional Studies with the Octameric and Dimerie Form of Mitochondri ~ l Creatine Kinase (2001) (5)
- Creatine supplementation improves neural progenitor cell survival in Huntington's disease (2016) (5)
- Plasma creatine and incident type 2 diabetes in a general population‐based cohort: The PREVEND study (2020) (5)
- Visualization of freeze-dried and shadowed myosin molecules immobilized on electron microscopic films. (1983) (5)
- Creatine homeostasis and protein energy wasting in hemodialysis patients (2021) (4)
- The structure of mitochondrial creatine kinase and its membrane binding properties. (1994) (4)
- Melting of myosin rod as revealed by electron microscopy. I. Effects of glycerol and anions on length and stability of myosin rod. (1986) (4)
- The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage (2016) (4)
- Creatine synthesis and transport during rat embryogenesis : spatiotemporal expression of AGAT , GAMT and CT 1 Braissant (2009) (4)
- Myosin light chain functions. (1986) (4)
- Integrated and Organized Cellular Energetic Systems (2009) (4)
- Creatine synthesis and transport during rat embryogenesis (2005) (4)
- Myofibrillar M-band proteins represent constituents of native thick filaments, frayed filaments and bare zone assemblages (1985) (4)
- Creatine supplementation stimulates collagen type I and osteoprotegerin secretion of healthy and osoteopenic primary human osteoblast-like cells in vitro (2008) (3)
- Comment on "toxic hepatitis in a group of 20 male body-builders taking dietary supplements" by. (2013) (3)
- Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation (2021) (3)
- Downregulation of the Na 1-Creatine Cotransporter in Failing Human Myocardium and in Experimental Heart Failure (1999) (3)
- Creatine transporter gene expression and protein localization in rat skeletal muscle (2001) (3)
- CRYSTAL STRUCTURE OF CHICKEN BRAIN-TYPE CREATINE KINASE AT 1.41 ANGSTROM RESOLUTION (1999) (3)
- A short review on creatine–creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy (2011) (3)
- An automated home-built low-cost fermenter suitable for large-scale bacterial expression of proteins in Escherichia coli. (2008) (3)
- Where Have the Fluxes Gone? (2010) (2)
- Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool (2002) (2)
- Mediated by the Kinase Domain AMP-activated Protein Kinase Are Homo-oligomerization and Activation of Enzyme Catalysis and Regulation : (2009) (2)
- Saks et a. 2The creatine kinase phosphotransfer network: Thermodynamic and kinetic consideratios the impact of the mitochondrial outer membrane and modelling approachesSubcell Biochem. 2007;46:27-65. (2014) (2)
- Creatine improves the metabolic state of murine and human neural stem cells and improves expansion and neuronal induction (2010) (2)
- EFFECTS OF TIMAX™ ON GROWTH AND DIFFERENTIATION OF HUMAN OSTEOBLAST- LIKE CELLS UNDER SERUM-FREE CULTURE CONDITIONS (2005) (1)
- A Short N-Terminal Domain of Mitochondrial Creatine Kinase is Involved in Octamer Formation but not in Membrane Binding (1993) (1)
- Plasma creatine concentration is associated with incident hypertension in a cohort enriched for the presence of high urinary albumin concentration: the Prevention of Renal and Vascular Endstage Disease study (2021) (1)
- Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin (2022) (1)
- Structural dynamics of creatine kinase (1996) (1)
- Creatine: a miserable life without it (2016) (1)
- Contents Vol. 18, 1996 (2004) (1)
- Calcium in muscle activation: A comparative approach by Johann Caspar Rüegg, Springer‐Verlag, Berlin, 1986 300 pp., 97 Figs., DM 198 (1988) (1)
- Mitochondrial Creatine Kinase (Mi-CK) Forms Octameric Molecules: Structure-Function Relationship and Implications for the CP-Shuttle (1989) (1)
- FTIR ATR Studies on Immobilized Mitochondrial Creatine Kinase (1998) (0)
- 2 Tracking and quantification of 32 P-labeled phosphopeptides in liquid 3 chromatography matrix-assisted laser desorption/ionization mass spectrometry (2009) (0)
- European research needs a dash of anarchy (2008) (0)
- P66-T Efficient Identification of Phosphorylation Sites in AMPK: Autoradiographical Visualization of Microfractionated Phosphopeptides using 384-PAC MALDI Plates. (2007) (0)
- Shape Changes in Myosin Induced by the Regulatory Light Chain Subunits (1989) (0)
- cartilage cells using creatine substances for treatment of bone- and and fabrics (1998) (0)
- Critical for Enzymatic Activity the Active Site of Creatine Kinase Is A Conserved Negatively Charged Cluster in REGULATION (2014) (0)
- Soy-based diet and creatine supplementation: effects on cell signaling and doxorubicin response in the rat heart (2022) (0)
- A Protein That Binds Specifically to the 1 Identified as the Muscle Form of Creatine (2016) (0)
- Interrelationships of Energy Metabolism to Oxidative Damage and Neurodegeneration (1998) (0)
- Science and Security: A European View (2003) (0)
- Effects of Creatine Supplementation on ATP Reserves, Expansion, Migration and Differentiationn of Neural Stem Cells (2011) (0)
- Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into (2010) (0)
- Regulation | Metabolite Channeling in Energy Metabolism (2021) (0)
- Scallop Muscle Na - Ca Exchanger can be Activated by Either AMPK and PK-A Through Phosphorylation of Ser621 in CBD2 (2010) (0)
- Calcium and energy transfer (2005) (0)
- Improving Neural Transplantation for Huntington`s Disease: Potemtoaö pf Creatome Supplementation (2012) (0)
- Subject Index Vol. 18, 1996 (1996) (0)
- The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage (2016) (0)
- distinct creatine transporter isoforms in muscle New creatine transporter assay and identification of (2016) (0)
- AP article 13.02.2014 (2014) (0)
- Different expression pattern of the creatine transporter and guanidinoacetate methyltransferase between adult rat forbrain and spinal cord cholinergic neurons (2010) (0)
- Brain Poster Session: Stem Cells and Gene Therapy (2009) (0)
- Unity in diversity (1987) (0)
- Developmental history of the two M-line proteins MM-creatine kinase and myomesin during myogenesis. (1982) (0)
- Subcellular Localization of Creatine Kinase in Electrocytes: Association with Acetylcholine Receptor-rich Membranes (2003) (0)
- Creatine homeostasis and protein energy wasting in hemodialysis patients (2021) (0)
- Donor Age Affects Creatine-Mediated Induction of Differentiaton on Striatal Neural Progenitor Cells (2011) (0)
- The extended, dynamic mitochondrial reticulum in skeletal muscle and the creatine kinase (CK)/phosphocreatine (PCr) shuttle are working hand in hand for optimal energy provision (2015) (0)
- Phosphorylation of Creatine Kinase in Myogenic Cells: Effects of Okadaic Acid and other Agents Affecting Cellular Protein Phosphorylation (1993) (0)
- CHAPTER 1 INTRODUCTION – CREATINE : CHEAP ERGOGENIC SUPPLEMENT WITH GREAT POTENTIAL FOR HEALTH AND DISEASE (2007) (0)
- Subpopulations of ventral mesencephalic dopaminergic neurons express the creatine transporter and AGAT but not GAMT: Implications for therapeutic application of Creatine for Parkinson`s disease (2010) (0)
- Age-dependent Effects of Creatine Supplementation on Striatal Neural Progenitor (2010) (0)
- Use of creatine based compounds to treat cells and bone and cartilage tissues. (1998) (0)
- Effects of Creatine Supplementation on Neural Progenitor Cells of Murine und Human Origin (2012) (0)
- Cholinergic neurons of adult rat forebrain and spinal cord display different expression patterns of the creatine transporter and GAMT (2010) (0)
- Improving Neural Transplantation for Ischemic Stroke: Potential of Creatine Supplementation (2012) (0)
- Creatine improves the metabolic state of murine and human neural stem cells and promotes expansion, migration and neuronal induction (2011) (0)
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