Theodor Otto Diener

Theodor Otto Diener's Degrees

PhD Plant Pathology University of California, Berkeley
Masters Plant Pathology University of California, Berkeley
Bachelors Plant Pathology University of California, Berkeley

Why Is Theodor Otto Diener Influential?

According to Wikipedia, Theodor Otto Diener was a Swiss-American plant pathologist. In 1971, he discovered that the causative agent of the potato spindle tuber disease is not a virus, but a novel agent, which consists solely of a short strand of single-stranded RNA without a protein capsid, eighty times smaller than the smallest viruses. He proposed to name it, and similar agents yet to be discovered, viroids. Viroids displaced viruses as the smallest known infectious agents.

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Theodor Otto Diener's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Potato spindle tuber "virus". IV. A replicating, low molecular weight RNA. (1971) (386)
Sensitive and Rapid Diagnosis of Potato Spindle Tuber Viroid Disease by Nucleic Acid Hybridization (1981) (218)
Circular RNAs: relics of precellular evolution? (1989) (162)
Viroids and Viroid Diseases (1979) (160)
Potato Spindle Tuber Virus: A Plant Virus with Properties of a Free Nucleic Acid (1967) (153)
Viroids and prions. (1982) (143)
Identification of multiple structural domains regulating viroid pathogenicity. (1992) (125)
Virus degradation and nucleic acid release in single-phase phenol systems. (1968) (118)
A proposed scheme for viroid classification and nomenclature (1998) (114)
Discovering viroids — a personal perspective (2003) (111)
Potato spindle tuber viroid. X. Visualization and size determination by electron microscopy. (1973) (105)
Phylogeny of viroids, viroidlike satellite RNAs, and the viroidlike domain of hepatitis delta virus RNA. (1991) (102)
Purified scrapie prions resist inactivation by UV irradiation (1987) (101)
Physiology of Virus-Infected Plants (1963) (100)
Potato spindle tuber virus: a plant virus with properties of a free nucleic acid. 3. Subcellular location of PSTV-RNA and the question of whether virions exist in extracts or in situ. (1971) (92)
Chrysanthemum stunt: a viroid disease. (1973) (91)
The viroid: biological oddity or evolutionary fossil? (2001) (88)
Nucleotide sequence and proposed secondary structure of Columnea latent viroid: a natural mosaic of viroid sequences. (1989) (87)
Potato spindle tuber viroid. 8. Correlation of infectivity with a UV-absorbing component and thermal denaturation properties of the RNA. (1972) (86)
Structural similarities between viroids and transposable genetic elements. (1983) (85)
Potato spindle tuber viroid. XII. An investigation of viroid RNA as a messenger for protein synthesis. (1974) (80)
Purified scrapie prions resist inactivation by procedures that hydrolyze, modify, or shear nucleic acids. (1987) (79)
Viroid processing: a model involving the central conserved region and hairpin I. (1986) (75)
Isolation and characterization of AS-1, a phycovirus infecting the blue-green algae, Anacystis nidulans and Synechococcus cedrorum. (1972) (75)
RNA intermediates in potato spindle tuber viroid replication. (1982) (73)
Are viroids escaped introns? (1981) (72)
Some physical and chemical properties of cucumber mosaic virus (strain Y) and of its isolated ribonucleic acid. (1965) (65)
Is the scrapie agent a viroid? (1972) (59)
Potato spindle tuber virus: a plant virus with properties of a free nucleic acid. II. Characterization and partial purification. (1969) (57)
Viroids: the smallest known agents of infectious disease. (1974) (55)
The two components of tobacco ringspot virus nucleic acid: origin and properties. (1966) (53)
Mechanism of viroid pathogenesis: differential activation of the interferon-induced, double-stranded RNA-activated, M(r) 68,000 protein kinase by viroid strains of varying pathogenicity. (1993) (53)
Blue-Green Algal Virus LPP-1: Purification and Partial Characterization (1964) (52)
Virus infection and other factors affecting ribonuclease activity of plant leaves. (1961) (51)
Phycovirus SM-1: a virus infecting unicellular blue-green algae. (1969) (51)
PrP and the nature of the scrapie agent (1987) (49)
Potato spindle tuber viroid. XIV. Replication in nuclei isolated from infected leaves. (1975) (48)
Origin and evolution of viroids and viroid-like satellite RNAs (2005) (48)
Indian bunchy top disease of tomato plants is caused by a distinct strain of citrus exocortis viroid. (1991) (46)
Citrus B viroid identified as a strain of hop stunt viroid (1988) (46)
Mexican papita viroid: putative ancestor of crop viroids. (1996) (46)
Phylogenetic Analysis of Viroid and Viroid-Like Satellite RNAs from Plants: A Reassessment (2001) (45)
Isolation of an infectious, ribonuclease-sensitive fraction from tobacco leaves recently inoculated with tobacco mosaic virus. (1962) (42)
The viroidlike structure and cellular location of anomalous RNA associated with the cadang-cadang disease. (1976) (42)
Potato Spindle Tuber (1987) (42)
Viroids: structure and function. (1979) (41)
Potato spindle tuber virus: a plant virus with properties of a free nucleic acid. I. Assay, extraction, and concentration. (1969) (39)
Separation and infectivity of circular and linear forms of potato spindle tuber viroid. (1977) (39)
The Viroids (1987) (39)
Measurement of viroid sequence homology by hybridization with complementary DNA prepared in vitro. (1978) (35)
Hybridization of potato spindle tuber viroid to cellular DNA of normal plants. (1976) (35)
Potato spindle tuber viroid. VI. Monodisperse distribution after electrophoresis in 20 per cent polyacrylamide gels. (1971) (35)
Viroids and the nature of viroid diseases. (1999) (33)
Potato spindle tuber viroid IX. Molecular-weight determination by gel electrophoresis of formylated RNA. (1973) (33)
Viroids: “living fossils” of primordial RNAs? (2016) (33)
Potato spindle tuber viroid. XIII. Inhibition of replication by actinomycin D. (1975) (32)
The subviral agents: Viroids (2005) (32)
Spot Hybridization for Detection of Viroids and Viruses (1984) (31)
Isolation of infectious ribonucleic acid from Southern bean mosaic virus. (1965) (29)
The role of the viroid central conserved region in cDNA infectivity. (1990) (27)
Highly infectious nucleic acid from crude and purified preparations of cucumber mosaic virus (Y strain) (1964) (26)
Potato spindle tuber viroid. XI. A comparison of the ultraviolet light sensitivities of PSTV, tobacco ringspot virus, and its satellite. (1974) (26)
Virology in Agriculture (1977) (26)
The correlation between the proportions of virus-related products and the infectious component during the synthesis of tobacco ringspot virus. (1966) (26)
Potato spindle tuber and citrus exocortis viroids undergo no major sequence changes during replication in two different hosts. (1978) (24)
Viroids and their interactions with host cells. (1982) (23)
Infectivity of chimeric viroid transcripts reveals the presence of alternative processing sites in potato spindle tuber viroid. (1989) (22)
Potato spindle tuber viroid. VII. Susceptibility of several solanaceous plant species to infection with low molecular-weight RNA. (1972) (20)
Analysis of Viroid Replication Following Agrobacterium-mediated Inoculation of Non-host Species with Potato Spindle Tuber Viroid cDNA (1988) (18)
A disease-associated host protein in viroid-infected tomato (1984) (18)
In vivo and in vitro decline of specific infectivity of tobacco ringspot virus correlated with nucleic acid degradation. (1968) (17)
Nucleotide sequence of a full-length infectious clone of the Indonesian strain of tomato apical stunt viroid (TASV). (1987) (17)
Similarities between the scrapie agent and the agent of the potato spindle tuber disease. (1973) (17)
Nuclear DNA from uninfected or potato spindle tuber viroid-infected tomato plants contains no detectable sequences complementary to cloned double-stranded viroid cDNA. (1981) (16)
Synthesis of RNA complementary to potato spindle tuber viroid using Q beta replicase. (1977) (16)
Changes in concentration of free amino acids and amides induced in tobacco plants by potato virus X and potato virus Y (1963) (16)
Construction of novel viroid chimeras containing portions of tomato apical stunt and citrus exocortis viroids. (1990) (16)
CHRYSANTHEMUM STUNT: A VIROID DISEASE (1974) (13)
Factors affecting the stability of tobacco mosaic virus. I. Ribonuclease-induced protection of virus from alkaline degradation. (1966) (13)
Reversible and irreversible inhibition of necrotic ringspot virus in cucumbers by pancreatic ribonuclease. (1959) (12)
Hybridization Analysis of Citrus Viroids with Citrus Exocortis Viroid- and Hop Stunt Viroid-specific Probes (1991) (12)
Beltsville Symposia in Agricultural Research. [I] Virology in agriculture. (1977) (11)
Potato spindle tuber viroid-specific double-stranded RNA in extracts from infected tomato leaves (1982) (11)
The viroid: big punch in a small package. (1993) (11)
A Plant Virus with Properties of a Free Ribonucleic Acid: Potato Spindle Tuber Virus (1971) (11)
In vivo synthesis of potato spindle tuber viroid: kinetic relationship between the circular and linear forms. (1978) (11)
Viroids: Abnormal Products of Plant Metabolism (1981) (11)
Detection of potato spindle tuber viroid by nucleic acid spot hybridization: Evaluation with tuber sprouts and true potato seed (1983) (10)
Autonomous and helper-dependent small pathogenic RNAs of plants: viroids and satellites. (1987) (10)
De novo synthesis of potato spindle tuber viroid as measured by incorporation of 32P. (1977) (9)
A Viroid Different from Citrus Exocortis Viroid Found in Commercial Citrus in Sicily (1988) (9)
Viroids: the smallest and simplest agents of infectious disease. How do they make plants sick? (1993) (9)
Portraits of viruses: the viroid. (1984) (8)
Potato spindle tuber viroid. V. Failure of immunological tests to disclose double-stranded RNA or RNA-DNA hybrids. (1971) (8)
Viroids as Prototypes or Degeneration Products of Viruses (1974) (7)
Viroids and viroid-like satellite RNAs: a phylogenetic analysis. (1991) (7)
Use of Snake Venom Phosphodiesterase in Place of Pancreatic Ribonuclease for the Testing of Nucleic Acid Preparations from Tobacco Mosaic Virus (1961) (6)
Chapter 1 – THE RECOGNITION OF SUBVIRAL PATHOGENS (1985) (6)
Plant-Pathogen Interactions in Plant Biotechnology (1999) (5)
Synthesis of DNA transcripts of potato spindle tuber viroid (1977) (5)
Free amino acids and amides in healthy and virus-infected Cherry and Peach leaves. (1960) (5)
Infectivity of phenol-extracted preparations from cucumber leaves infected with necrotic ringspot virus. (1959) (5)
THE VIROID: A SUBVIRAL PATHOGEN (1984) (5)
Chapter 14 – PM-ANTIGEN: A DISEASE-ASSOCIATED HOST PROTEIN IN VIROID-INFECTED TOMATO (1985) (4)
Hepatitis delta virus-like agents: an overview. (1993) (4)
The smallest known agents of infectious disease. (1974) (3)
Subviral pathogens of plants: The viroids (1989) (3)
Rabies burden in Côte d'Ivoire. (2021) (3)
CHAPTER 7 – Viroids: Persistence in Plants, Evolution, and Possible Animal and Human Disease Agents (1978) (2)
Chick "crooked-toe" syndrome induced by polar lipid in synovial fluids from some rheumatoid arthritis patients. (1982) (2)
The effect of tetrachloro-o-benzoquinone on southern bean mosaic virus and on its nucleic acid. (1971) (2)
Partial degradation of tobacco ringspot virus in a single-phase phenol system: formation of new products. (1971) (2)
Viroid discovery. (1979) (2)
The post-Loeffler era: contribution of German virologists. (2000) (2)
Mutational analysis of potato spindle tuber viroid (1987) (2)
Of Viroids and Prions (2018) (2)
Viroids: Minimal Biological Systems (1982) (2)
Understanding replication mechanisms in viroids and viroidlike RNAs. (1996) (1)
Understanding replication mechanisms in viroids and viroidlike RNAs (1996) (1)
The Demand for Marijuana, Cocaine, and Heroin (2002) (1)
Persistent pathogens and wildlife reservoirs (2021) (1)
Towards an understanding of viroid nature and replication. (1976) (1)
Patents and literature (1986) (1)
Viroids: autoinducing regulatory RNAs? (1977) (1)
Diagnosis of Viroid-Caused Plant Diseases by Nucleic Acid Hybridization (1985) (1)
Virus Terminology and the Viroid: A Rebuttal (1973) (1)
The determination of nucleic acid content and composition of fruit tree and other plant leaves. (1960) (1)
Viroids in Agriculture (1977) (0)
Plant virology. Second edition By R. E. F. Matthews. New York: Academic Press. (1981). 897 pp. $59.50 (1982) (0)
The Enigma of Viroid Pathogenesis (1986) (0)
Cucumber Pale Fruit (1987) (0)
Replication and pathology of hepatitis delta virus in tobacco plants (Nicotiana sylvestris): a negative report. (1987) (0)
Subviral Pathogens: Viroids and Prions (1984) (0)
The Subviral Agents (2005) (0)
The Discovery of the Viroid (1998) (0)
On the Existence of Animal Viroids (2016) (0)
Letter to the editor (2014) (0)
Virology in agriculture : invited papers presented at a symposium held May 10-12, 1976, at the Beltsville Agricultural Research Center (BARC), Beltsville, Maryland (1977) (0)
Viroids: “living fossils” of primordial RNAs? (2016) (0)
Twenty-five years of viroid research: facts, enigmas, and hunches (1995) (0)
Subject Index, Vol. 35, 1993 (1993) (0)
Viroids and Genetic Engineering (1983) (0)
Tomato Bunchy Top (1987) (0)
Viroids : minimal genetic systems : (RNA, plant pathogens, replication, pathogenesis) (1980) (0)
Viroids as disease agents. (1982) (0)
The Econ Department is on the Web (2008) (0)
Viroids and prions ( potato spindle tuber disease / scrapie / proteinaceous infectious particles / infectious RNA ) (0)
DETECTION OF VIROIDS IN PLANTS (1985) (0)

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