Theodore W. Randolph
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Theodore W. Randolphchemistry Degrees
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Chemical Engineering
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Chemistry
Theodore W. Randolph's Degrees
- PhD Chemical Engineering University of Delaware
- Bachelors Chemical Engineering University of Delaware
Why Is Theodore W. Randolph Influential?
(Suggest an Edit or Addition)Theodore W. Randolph's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation (2003) (1249)
- Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice (1997) (609)
- Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. (2009) (506)
- Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. (1999) (471)
- Water-in-Carbon Dioxide Microemulsions: An Environment for Hydrophiles Including Proteins (1996) (406)
- The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf. (2001) (347)
- Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor (2003) (310)
- Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions. (1998) (279)
- Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization. (2001) (271)
- Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation. (2005) (267)
- Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. (2009) (250)
- Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII. (1998) (230)
- Rational design of stable lyophilized protein formulations: theory and practice. (2002) (220)
- Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. (2012) (216)
- Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state. (1997) (206)
- Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis. (2003) (194)
- Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. (2010) (192)
- IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles. (2009) (190)
- Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition. (2002) (180)
- A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma. (1998) (180)
- Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing. (2008) (180)
- High pressure fosters protein refolding from aggregates at high concentrations. (1999) (170)
- Response of a concentrated monoclonal antibody formulation to high shear (2009) (169)
- Surfactant-protein interactions. (2002) (166)
- Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity. (2007) (166)
- Phase separation of excipients during lyophilization: effects on protein stability. (1997) (166)
- Immunogenicity of aggregates of recombinant human growth hormone in mouse models. (2009) (162)
- Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. (2010) (160)
- Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent (1997) (158)
- Aggregation of recombinant human interferon gamma: kinetics and structural transitions. (1998) (157)
- Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation. (1999) (154)
- Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway. (2011) (147)
- Inhibition of stress-induced aggregation of protein therapeutics. (1999) (143)
- Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies. (2009) (142)
- Effects of surfaces and leachables on the stability of biopharmaceuticals. (2011) (140)
- Mechanism Governing Microparticle Morphology during Precipitation by a Compressed Antisolvent: Atomization vs Nucleation and Growth (2000) (138)
- Enzymatic Oxidation of Cholesterol Aggregates in Supercritical Carbon Dioxide (1988) (137)
- Effects of sucrose on conformational equilibria and fluctuations within the native‐state ensemble of proteins (2003) (136)
- Protein aggregation and particle formation in prefilled glass syringes. (2014) (134)
- Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran. (2000) (132)
- Thermodynamic Modulation of Light Chain Amyloid Fibril Formation* (2000) (129)
- Water-in-carbon dioxide emulsions: Formation and stability (1999) (128)
- Permeability and Diffusion in Vitreous Humor: Implications for Drug Delivery (2004) (127)
- Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic Technique (2004) (126)
- Molten Globule Intermediate of Recombinant Human Growth Hormone: Stabilization with Surfactants (1996) (119)
- Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation* (2003) (118)
- Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition. (1998) (118)
- Enzymatic catalysis in a supercritical fluid (1985) (118)
- Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. (2005) (117)
- Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions. (2010) (116)
- Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations. (2002) (115)
- Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. (1998) (112)
- Effects of Tween 80 and Sucrose on Acute Short-Term Stability and Long-Term Storage at − 20 C of a Recombinant Hemoglobin (1998) (112)
- Manipulation of Lyophilization‐Induced Phase Separation: Implications For Pharmaceutical Proteins (1997) (108)
- Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin. (2010) (101)
- Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying. (2001) (101)
- Computer Simulation of Convective and Diffusive Transport of Controlled-Release Drugs in the Vitreous Humor (2004) (100)
- Precipitation of a monoclonal antibody by soluble tungsten. (2009) (99)
- Aggregation of a monoclonal antibody induced by adsorption to stainless steel (2010) (99)
- Effects of phase separating systems on lyophilized hemoglobin. (1996) (97)
- Enzyme‐caytalyzed oxidation of cholesterol in supercritical carbon dioxide (1988) (95)
- Production of particles of therapeutic proteins at the air–water interface during compression/dilation cycles (2012) (95)
- Mechanism of polyethylene glycol interaction with the molten globule folding intermediate of bovine carbonic anhydrase B. (1992) (91)
- High hydrostatic pressure as a tool to study protein aggregation and amyloidosis. (2002) (91)
- High Pressure Refolding of Recombinant Human Growth Hormone from Insoluble Aggregates (2001) (89)
- Counteracting Effects of Renal Solutes on Amyloid Fibril Formation by Immunoglobulin Light Chains* (2001) (85)
- Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochloride. (2000) (85)
- Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ (2001) (83)
- Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations. (2011) (82)
- Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma. (2003) (81)
- Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor. (2006) (78)
- Water Core within Perfluoropolyether-Based Microemulsions Formed in Supercritical Carbon Dioxide (1997) (77)
- Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation. (2015) (75)
- Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid. (1999) (75)
- Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. (2015) (74)
- Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges. (2016) (74)
- The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study. (2013) (73)
- Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability. (2009) (73)
- Protease autolysis in heavy-duty liquid detergent formulations: effects of thermodynamic stabilizers and protease inhibitors (2004) (72)
- High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics. (2008) (72)
- A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20. (2002) (71)
- Protein-solute interactions affect the outcome of ultrafiltration/diafiltration operations. (2004) (70)
- IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers. (2013) (70)
- Engineering challenges of protein formulations (2007) (69)
- Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins. (2011) (68)
- Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene. (2012) (67)
- Effects of drying methods and additives on the structure, function, and storage stability of subtilisin: role of protein conformation and molecular mobility (2002) (66)
- Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces. (2013) (65)
- Particles shed from syringe filters and their effects on agitation-induced protein aggregation. (2012) (64)
- Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible Polymers (1996) (64)
- Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures. (2004) (63)
- Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying. (2008) (61)
- Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure (2006) (61)
- Process Variable Implications for Residual Solvent Removal and Polymer Morphology in the Formation of Gentamycin-Loaded Poly (L-lactide) Microparticles (1998) (61)
- Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice (2015) (60)
- Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. (2018) (59)
- Electrostatic Interactions Influence Protein Adsorption (but Not Desorption) at the Silica-Aqueous Interface. (2015) (58)
- Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. (2005) (58)
- The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin. (2000) (58)
- Kinetics and Energetics of Assembly, Nucleation, and Growth of Aggregates and Fibrils for an Amyloidogenic Protein (2002) (57)
- Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution. (2004) (57)
- Adsorption of monoclonal antibodies to glass microparticles. (2011) (56)
- Freezing- and Drying-Induced Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives (1999) (55)
- Sedimentation velocity analytical ultracentrifugation and SEDFIT/c(s): limits of quantitation for a monoclonal antibody system. (2007) (55)
- The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution. (2001) (54)
- Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions. (2012) (54)
- Dense‐gas solvent‐solute clusters at near‐infinite dilution: EPR spectroscopic evidence (1993) (53)
- Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine. (2008) (52)
- Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor. (2005) (51)
- Manipulation of particle size distribution of poly(l-lactic acid) nanoparticles with a jet-swirl nozzle during precipitation with a compressed antisolvent (2003) (49)
- Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis. (1998) (49)
- High‐pressure refolding of bikunin: Efficacy and thermodynamics (2004) (49)
- Free-radical reactions in supercritical ethane : a probe of supercritical fluid structure (1992) (48)
- Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations. (2017) (48)
- High-pressure studies on protein aggregates and amyloid fibrils. (2006) (47)
- Surfactant-Stabilized Protein Formulations: A Review of Protein-Surfactant Interactions and Novel Analytical Methodologies (1997) (46)
- Role of electrostatic repulsion on colloidal stability of Bacillus halmapalus alpha-amylase. (2009) (46)
- Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor. (2000) (45)
- Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature. (2014) (45)
- In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations. (2015) (45)
- Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium. (2008) (44)
- Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics. (2007) (42)
- Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples. (2014) (42)
- Development of a highly thermostable, adjuvanted human papillomavirus vaccine. (2015) (42)
- Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. (2009) (41)
- Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist. (2006) (41)
- Refolding of proteins from inclusion bodies is favored by a diminished hydrophobic effect at elevated pressures (2009) (41)
- Common excipients impair detection of protein aggregates during sedimentation velocity analytical ultracentrifugation. (2009) (41)
- Freezing-induced perturbation of tertiary structure of a monoclonal antibody. (2014) (40)
- Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity. (2016) (40)
- Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization. (2013) (39)
- Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes. (2015) (39)
- High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. (2008) (39)
- Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing Operations (2010) (38)
- Effects of Tween 80 and sucrose on acute short-term stability and long-term storage at -20 degrees C of a recombinant hemoglobin. (1998) (37)
- Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization. (1999) (37)
- Biocatalysis in Supercritical Fluids (1991) (37)
- Conformational stability of lyophilized PEGylated proteins in a phase-separating system. (1999) (36)
- Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine. (2009) (35)
- Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes. (2015) (35)
- Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations. (2005) (34)
- Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces. (2016) (34)
- Hydrophobic ion pairing of isoniazid using a prodrug approach. (2002) (33)
- Therapeutic protein and peptide formulation and delivery (1997) (33)
- High‐Pressure Refolding of Disulfide‐Cross‐Linked Lysozyme Aggregates: Thermodynamics and Optimization (2002) (33)
- High‐pressure studies of aggregation of recombinant human interleukin‐1 receptor antagonist: Thermodynamics, kinetics, and application to accelerated formulation studies (2005) (32)
- Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry. (2008) (31)
- Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. (2010) (31)
- Effect of salts and sugars on phase separation of polyvinylpyrrolidone[ndash ]dextran solutions induced by freeze-concentration (1998) (31)
- Cholesterol aggregation and interaction with cholesterol oxidase in supercritical carbon dioxide. (1988) (30)
- Long‐Term Storage of Proteins (2002) (30)
- Quasicritical behavior of dense-gas solventsolute clusters at near-infinite dilution (1993) (29)
- Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses. (2012) (29)
- In vitro and in vivo evaluation of the effects of PLA microparticle crystallinity on cellular response. (2003) (29)
- Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice. (2015) (29)
- Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. (2014) (29)
- UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences. (2014) (28)
- Selective domain stabilization as a strategy to reduce fusion protein aggregation. (2012) (28)
- Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation. (2012) (28)
- Stability of lyophilized and spray dried vaccine formulations. (2021) (28)
- Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. (2009) (27)
- Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study. (2009) (27)
- Nucleation and growth rates of poly(L-lactic acid) microparticles during precipitation with a compressed-fluid antisolvent. (2004) (27)
- Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice. (2016) (27)
- Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation. (2014) (27)
- Dissolution and Partitioning Behavior of Hydrophobic Ion-Paired Compounds (2002) (27)
- Influence of hydrostatic pressure and cosolutes on RNA tertiary structure. (2007) (26)
- Albinterferon α2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation. (2014) (26)
- Pressure dependence of subtilisin crystallization kinetics (2000) (25)
- Contributions of local mobility and degree of retention of native secondary structure to the stability of recombinant human growth hormone (rhGH) in glassy lyophilized formulations (2013) (25)
- Storage stability of keratinocyte growth factor-2 in lyophilized formulations: effects of formulation physical properties and protein fraction at the solid-air interface. (2014) (25)
- Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist. (2005) (24)
- Surfactant‐Induced Unfolding of Cellulase: Kinetic Studies (2006) (24)
- Investigation of Protein-Surfactant Interactions by Analytical Ultracentrifugation and Electron Paramagnetic Resonance: The Use of Recombinant Human Tissue Factor as an Example (1999) (24)
- Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. (2017) (23)
- Ca2+–Surfactant Interactions Affect Enzyme Stability in Detergent Solutions (2005) (23)
- Antibody responses in mice to particles formed from adsorption of a murine monoclonal antibody onto glass microparticles. (2014) (23)
- Pressure effect on subtilisin crystallization and solubility (1999) (23)
- Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. (2015) (23)
- Thermostable Ebola virus vaccine formulations lyophilized in the presence of aluminum hydroxide (2019) (23)
- Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations. (2008) (21)
- Rotational Relaxation in Supercritical Carbon Dioxide Revisited: A Study of Solute-Induced Local Density Augmentation (1998) (21)
- Does Critical Clustering Affect Reaction Rate Constants? Molecular Dynamics Studies in Pure Supercritical Fluids (1994) (20)
- Protein–protein interactions controlling interfacial aggregation of rhIL‐1ra are not described by simple colloid models (2018) (19)
- The effect of protein PEGylation on physical stability in liquid formulation. (2014) (19)
- Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence. (2017) (19)
- Quaternary conformational stability: The effect of reversible self‐association on the fibrillation of two insulin analogs (2011) (19)
- Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics. (2011) (19)
- Molecular trajectories provide signatures of protein clustering and crowding at the oil/water interface. (2015) (17)
- The two faces of His‐tag: Immune response versus ease of protein purification (2012) (17)
- Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants. (2007) (17)
- Stability of Subtilisin and Lysozyme under High Hydrostatic Pressure (2000) (17)
- Recombinant murine growth hormone from E. coli inclusion bodies: Expression, high‐pressure solubilization and refolding, and characterization of activity and structure (2010) (17)
- Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions. (2014) (17)
- Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes. (2004) (16)
- Alveolar macrophage cell line is not activated by exposure to polymeric microspheres (1998) (16)
- Crystallization of recombinant human growth hormone at elevated pressures: Pressure effects on PEG‐induced volume exclusion interactions (2010) (16)
- Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate. (2012) (16)
- Preformulation study of highly purified inactivated polio vaccine, serotype 3. (2014) (16)
- Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions. (2016) (15)
- Machine learning and statistical analyses for extracting and characterizing “fingerprints” of antibody aggregation at container interfaces from flow microscopy images (2020) (15)
- Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose. (2016) (14)
- Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. (2016) (14)
- Toxicology of a PFPE Surfactant. (1996) (14)
- Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives (2004) (14)
- Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. (2007) (14)
- Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. (2011) (13)
- Container surfaces control initiation of cavitation and resulting particle formation in protein formulations following application of mechanical shock. (2019) (13)
- Encapsulating DNA within biodegradable polymeric microparticles. (2002) (12)
- Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses. (2018) (12)
- Mechanism of microparticle formation in the compressed antisolvent precipitation and photopolymerization (CAPP) process (2003) (12)
- Aggregation and Particle Formation During Pumping of an Antibody Formulation are Controlled by Electrostatic Interactions between Pump Surfaces and Protein Molecules. (2020) (12)
- The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin. (2015) (12)
- Steric Repulsion Forces Contributed by PEGylation of Interleukin-1 Receptor Antagonist Reduce Gelation and Aggregation at the Silicone Oil-Water Interface. (2019) (11)
- Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology (2020) (11)
- Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions. (2018) (11)
- DEHP Nanodroplets Leached from Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum. (2020) (11)
- Scale-up criteria for an injector with a confined mixing chamber during precipitation with a compressed-fluid antisolvent (2006) (10)
- Effects of tubing type, operating parameters and surfactants on particle formation during peristaltic filling pump processing of a monoclonal antibody formulation. (2020) (10)
- Compressed Antisolvent Precipitation and Photopolymerization To Form Highly Cross-Linked Polymer Particles (2002) (10)
- Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology (2020) (10)
- Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin‐1 receptor antagonist: Density differences enable pressure‐modulated refolding (2007) (10)
- Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays. (2020) (10)
- Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions. (2019) (10)
- The Effect of Container Surface Passivation on Aggregation of Intravenous Immunoglobulin Induced by Mechanical Shock (2020) (9)
- Role of Crystallinity in Retention of Polymer Particle Morphology in the Presence of Compressed Carbon Dioxide (1999) (9)
- Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant. (2021) (9)
- Lyophilization of a triply unsaturated phospholipid: effects of trace metal contaminants. (2013) (9)
- Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions. (2013) (9)
- Molecular simulation and electron paramagnetic resonance (EPR) studies of rapid bimolecular reactions in supercritical fluids (1996) (8)
- Machine learning and accelerated stress approaches to differentiate potential causes of aggregation in polyclonal antibody formulations during shipping. (2021) (8)
- Strategies for Bulk Storage and Shipment of Proteins (2010) (8)
- Effect of solute‐solute correlations on rapid reactions in supercritical fluids (1995) (7)
- Electrochemical determination of dissolution rates of lyophilized pharmaceutical formulations. (2001) (7)
- Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations. (2019) (7)
- Physical Instability of Peptides and Proteins (2012) (7)
- Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations. (2018) (6)
- Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation. (2013) (6)
- Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation. (2020) (6)
- Microemulsions, Emulsions and Latexes (2007) (6)
- Atomic-Layer Deposition Processes Applied to Phage λ and a Phage-Like Particle Platform Yield Thermostable, Single-Shot Vaccines. (2022) (5)
- Insulin Fibril Formation Caused by Mechanical Shock and Cavitation. (2021) (5)
- Sub-visible Particles in IVIg Formulations Activate Complement in Human Serum. (2020) (5)
- Ultrasonic velocity measurements in supercritical jet fuel (1997) (4)
- Corrigendum to ''Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium" (Anal. Biochem. 377 (2008) 128-133) (2008) (4)
- Do solute-solute interactions affect activation-limited reactions? A Brownian dynamics study (1996) (4)
- Thermostability of a Trivalent, Capsomere-Based Vaccine for Human Papillomavirus Infection. (2021) (3)
- Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy (2022) (3)
- Controlled release and the concentration distribution in the vitreous humor (1999) (2)
- Machine learning analysis provides insight into mechanisms of protein particle formation inside containers during mechanical agitation. (2022) (2)
- An Interlaboratory Comparison on the Characterization of a Sub-micrometer Polydisperse Particle Dispersion. (2021) (1)
- Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice (2014) (1)
- Response to Comment to the Editor. (2017) (1)
- A method of producing an immunologically active adjuvansbundet dried vaccine composition (2008) (1)
- Pressure Control of Reactions in Supercritical Fluids: Thermodynamics and Kinetics (1992) (1)
- Using Deep Convolutional Neural Networks to Circumvent Morphological Feature Specification when Classifying Subvisible Protein Aggregates from Micro-Flow Images (2017) (1)
- A Discussion of Limitations on the Use of Polymers for Stabilization of Proteins During the Freezing Portion of Lyophilization (1997) (1)
- Formulation Approaches and Strategies for Vaccines and Adjuvants (2013) (1)
- Blocatalysls In Supercrltlcal Fluids (1991) (0)
- Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy (2022) (0)
- Höjtryksrefoldning of protein aggregates and inclusion bodies (1999) (0)
- A Single Dose, Thermostable, Trivalent Human Papillomavirus Vaccine Formulated Using Atomic Layer Deposition. (2023) (0)
- Improved proteindisaggregering and refolding under pressure (2001) (0)
- Improved decay and refolding of proteins using high pressure (2001) (0)
- Dispositifs et procedes de production de particules (2002) (0)
- Aggregation of amphipathic peptides at an aqueous–organic interface using coarse-grained simulations (2017) (0)
- Machine learning approaches to root cause analysis, characterization, and monitoring of subvisible particles in monoclonal antibody formulations (2022) (0)
- Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in both Mice and Non-human Primates. (2022) (0)
- Carbonaceous Deposit Formation from Advanced Fuels Under Supercritical Conditions (1997) (0)
- Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation (2021) (0)
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What Schools Are Affiliated With Theodore W. Randolph?
Theodore W. Randolph is affiliated with the following schools:
