Thirumala-Devi Kanneganti
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Indian immunologist
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Thirumala-Devi Kannegantibiology Degrees
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Biology
Thirumala-Devi Kanneganti's Degrees
- PhD Microbiology Osmania University
- Masters Microbiology Osmania University
- Bachelors Microbiology Osmania University
Why Is Thirumala-Devi Kanneganti Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thirumala-Devi Kanneganti is an immunologist and is the Rose Marie Thomas Endowed Chair, Vice Chair of the Department of Immunology, and Member at St. Jude Children's Research Hospital. She is also Director of the Center of Excellence in Innate Immunity and Inflammation at St. Jude Children's Research Hospital. Her research interests include investigating fundamental mechanisms of innate immunity, including inflammasomes and inflammatory cell death, PANoptosis, in infectious and inflammatory disease and cancer.
Thirumala-Devi Kanneganti's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages (2006) (1157)
- Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 (2006) (1150)
- Intracellular NOD-like receptors in host defense and disease. (2007) (996)
- Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease (2015) (940)
- Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases (2017) (891)
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. (2010) (837)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*> (2006) (698)
- Regulation of inflammasome activation (2015) (685)
- The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. (2009) (684)
- Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins (2015) (641)
- The ketone metabolite β-hydroxybutyrate blocks NLRP 3 inflammasome – mediated inflammatory disease (2015) (622)
- Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020) (609)
- Inflammasome is a central player in the induction of obesity and insulin resistance (2011) (602)
- Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens (2008) (594)
- Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. (2007) (559)
- RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs1 (2007) (491)
- The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. (2010) (488)
- Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf* (2006) (479)
- Converging roles of caspases in inflammasome activation, cell death and innate immunity (2015) (471)
- The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016) (468)
- RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 (2014) (444)
- Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia (2010) (425)
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes (2014) (411)
- Central roles of NLRs and inflammasomes in viral infection (2010) (396)
- Immunological complications of obesity (2012) (392)
- Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis (2014) (386)
- The C-terminal half of Phytophthora infestans RXLR effector AVR3a is sufficient to trigger R3a-mediated hypersensitivity and suppress INF1-induced cell death in Nicotiana benthamiana. (2006) (369)
- Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria* (2007) (354)
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. (2011) (341)
- IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation (2010) (339)
- Diverging inflammasome signals in tumorigenesis and potential targeting (2019) (339)
- NLRP6 Negatively Regulates Innate Immunity and Host Defense Against Bacterial Pathogens (2012) (335)
- Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection (2013) (306)
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes *S (2008) (289)
- Critical role for Ipaf in Pseudomonas aeruginosa‐induced caspase‐1 activation (2007) (285)
- Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis (2013) (280)
- ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways (2016) (280)
- Inflammasome activation and assembly at a glance (2017) (275)
- Mitochondria: diversity in the regulation of the NLRP3 inflammasome. (2015) (274)
- Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. (2010) (258)
- The inflammasome puts obesity in the danger zone. (2012) (251)
- Inflammasomes and Cancer (2017) (249)
- Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis. (2020) (247)
- Dietary modulation of the microbiome affects autoinflammatory disease (2014) (247)
- TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines (2021) (247)
- Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer (2015) (240)
- The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen (2006) (232)
- Recent advances in inflammasome biology. (2018) (232)
- Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens* (2012) (228)
- AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity (2016) (228)
- The Nlrp3 inflammasome: contributions to intestinal homeostasis. (2011) (228)
- Caspase-7: a protease involved in apoptosis and inflammation. (2010) (223)
- Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation (2014) (213)
- NLRP3 inflammasome in cancer and metabolic diseases (2021) (212)
- IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes (2016) (211)
- Inflammasomes and autoimmunity. (2011) (211)
- Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. (2015) (205)
- Caspase‐1 inflammasomes in infection and inflammation (2007) (204)
- The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome‐Induced Inflammation (2018) (197)
- Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes1 (2006) (191)
- DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome (2019) (186)
- The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans (2011) (185)
- Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells1 (2007) (182)
- Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation (2014) (181)
- Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection (2009) (181)
- The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection (2015) (174)
- MiR-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response (2009) (165)
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense (2020) (164)
- Innate immunity: the first line of defense against SARS-CoV-2 (2022) (157)
- Synergistic interactions of the plant cell death pathways induced by Phytophthora infestans Nepl-like protein PiNPP1.1 and INF1 elicitin. (2006) (155)
- Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense1 (2006) (152)
- RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3 (2013) (151)
- ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. (2016) (151)
- Mechanisms governing inflammasome activation, assembly and pyroptosis induction (2017) (148)
- ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019) (147)
- IL-1 family cytokines trigger sterile inflammatory disease (2012) (147)
- Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. (2010) (144)
- NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer (2016) (143)
- Function and regulation of IL‐1α in inflammatory diseases and cancer (2018) (140)
- Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) (2020) (139)
- Role of Inflammasomes in Host Defense against Citrobacter rodentium Infection* (2012) (137)
- The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis (2011) (136)
- Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes (2020) (135)
- Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome* (2009) (134)
- Novel roles for caspase-8 in IL-1β and inflammasome regulation. (2015) (133)
- Protective roles for caspase-8 and cFLIP in adult homeostasis. (2013) (129)
- TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation (2018) (129)
- The expanding role of NLRs in antiviral immunity (2013) (129)
- Deregulated inflammasome signaling in disease (2011) (128)
- Toward targeting inflammasomes: insights into their regulation and activation (2020) (127)
- TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation* (2011) (126)
- The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation1 (2007) (126)
- IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis. (2016) (125)
- Nlrp3: an immune sensor of cellular stress and infection. (2010) (124)
- MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. (2015) (124)
- The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. (2012) (122)
- Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines (2020) (120)
- Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease (2019) (119)
- Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. (2011) (118)
- Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. (2011) (118)
- The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) (2020) (117)
- NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells (2015) (116)
- Role of AIM2 inflammasome in inflammatory diseases, cancer and infection (2019) (115)
- Inflammasome control of viral infection. (2015) (115)
- Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation (2014) (114)
- IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation (2018) (113)
- The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) (2020) (113)
- ZBP1: Innate Sensor Regulating Cell Death and Inflammation. (2017) (113)
- NOD‐like receptor (NLR) signaling beyond the inflammasome (2010) (111)
- Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells (2016) (109)
- Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation (2015) (109)
- Differential roles of caspase-1 and caspase-11 in infection and inflammation (2017) (108)
- Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection (2020) (106)
- Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59 (2011) (106)
- Critical role for inflammasome-independent IL-1β production in osteomyelitis (2013) (106)
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection (2013) (105)
- Unsolved Mysteries in NLR Biology (2013) (105)
- ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death (2017) (104)
- Inflammasome-Derived IL-1β Regulates the Production of GM-CSF by CD4+ T Cells and γδ T Cells (2012) (104)
- Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes (2010) (103)
- An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. (2015) (102)
- Gasdermin D: the long-awaited executioner of pyroptosis (2015) (99)
- Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5 (2015) (98)
- SYK‐CARD9 Signaling Axis Promotes Gut Fungi‐Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer (2018) (96)
- Inflammasome-independent Role of Apoptosis-associated Speck-like Protein Containing a CARD (ASC) in T Cell Priming Is Critical for Collagen-induced Arthritis* (2010) (96)
- MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. (2015) (95)
- Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice (2018) (94)
- Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B (2016) (93)
- Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins (2017) (93)
- AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense (2021) (89)
- p38α signaling programs dendritic cells to drive TH17 cell differentiation and autoimmune inflammation (2011) (89)
- The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity (2009) (88)
- From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021) (86)
- Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. (2017) (84)
- NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis (2016) (82)
- Role of the Nlrp3 Inflammasome in Microbial Infection (2010) (82)
- Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection (2014) (82)
- Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 (2017) (82)
- The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. (2015) (81)
- Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice (2013) (80)
- Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection (2013) (79)
- DNA Sensing in the Innate Immune Response. (2020) (78)
- Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans. (2009) (77)
- Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. (2020) (75)
- Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. (2011) (75)
- Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β (2017) (73)
- Interferon‐inducible guanylate‐binding proteins at the interface of cell‐autonomous immunity and inflammasome activation (2017) (73)
- The 'cytokine storm': molecular mechanisms and therapeutic prospects. (2021) (72)
- Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9 (2017) (72)
- Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging (2019) (72)
- Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. (2010) (71)
- Inflammasomes and the fine line between defense and disease. (2019) (69)
- A functional genetic assay for nuclear trafficking in plants. (2007) (68)
- Lung &ggr;&dgr; T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity (2018) (68)
- Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation (2017) (67)
- Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation (2018) (67)
- Innate immunity against Leishmania infections (2015) (66)
- The inflammasome adaptor ASC regulates adaptive immune cell functions by controlling DOCK2-mediated Rac activation and actin polymerization (2011) (66)
- Computational and comparative analyses of 150 full-length cDNA sequences from the oomycete plant pathogen Phytophthora infestans. (2006) (65)
- Caspases in Cell Death, Inflammation, and Pyroptosis (2020) (64)
- IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection (2018) (60)
- Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. (2009) (58)
- Regulation and functions of NLRP3 inflammasome during influenza virus infection (2017) (58)
- Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection (2016) (58)
- ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. (2021) (58)
- PANoptosis in microbial infection (2020) (55)
- Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis. (2020) (55)
- Galactosaminogalactan activates the inflammasome to provide host protection (2020) (54)
- Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. (2011) (54)
- IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis (2014) (54)
- Inflammatory Bowel Disease and the NLRP3 Inflammasome (2017) (53)
- The inflammasome: firing up innate immunity (2015) (53)
- The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development (2020) (52)
- NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer (2017) (51)
- Differential role of the NLRP3 inflammasome in infection and tumorigenesis (2019) (51)
- Regulation of immune pathways by the NOD-like receptor NLRC5. (2012) (49)
- Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL‐1&agr;‐Mediated Inflammatory Disease (2017) (48)
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis) (2020) (47)
- Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulphate-induced colitis (2014) (46)
- Cutting Edge: SHARPIN Is Required for Optimal NLRP3 Inflammasome Activation (2015) (45)
- Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection (2014) (45)
- Reciprocal Regulation of Activating and Inhibitory Fcγ Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy (2010) (44)
- Asc-Dependent and Independent Mechanisms Contribute to Restriction of Legionella Pneumophila Infection in Murine Macrophages (2010) (44)
- Borrelia species induce inflammasome activation and IL‐17 production through a caspase‐1‐dependent mechanism (2011) (44)
- Autoinflammatory Skin Disorders: The Inflammasomme in Focus. (2016) (43)
- Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection (2018) (43)
- Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth (2021) (43)
- Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida (2018) (43)
- Cell death–mediated cytokine release and its therapeutic implications (2019) (42)
- Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa (2018) (41)
- Programming inflammatory cell death for therapy. (2021) (41)
- Autophagy is redundant for the host defense against systemic Candida albicans infections (2014) (38)
- NLRP3 inflammasome activation triggers gasdermin D–independent inflammation (2021) (38)
- NLRP6 in infection and inflammation. (2013) (37)
- Advances in Understanding Activation and Function of the NLRC4 Inflammasome (2021) (37)
- Gasdermin D Flashes an Exit Signal for IL-1. (2018) (36)
- NLRP12 in innate immunity and inflammation. (2020) (36)
- The role of inflammasome modulation in virulence (2012) (36)
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors (2016) (35)
- Genetic deficiency of NOD2 confers resistance to invasive aspergillosis (2018) (35)
- Membrane Damage during Listeria monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response (2012) (34)
- DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma. (2020) (34)
- Inflammasomes in the pathophysiology of autoinflammatory syndromes (2020) (33)
- Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components (2017) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Inflammatory cell death in intestinal pathologies (2017) (32)
- MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis (2012) (31)
- RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis. (2020) (31)
- Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins (2021) (31)
- ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis (2018) (31)
- TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy (2018) (29)
- Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis (2016) (29)
- DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota. (2016) (29)
- COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death. (2020) (29)
- Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection. (2018) (29)
- Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors. (2015) (27)
- Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice (2018) (27)
- Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton’s tyrosine kinase-dependent pathway (2019) (27)
- Intracellular innate immune receptors: Life inside the cell (2020) (27)
- Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease (2014) (27)
- Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3 (2012) (26)
- Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor (2017) (25)
- Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD (2020) (25)
- Autophagy Modulates Borrelia burgdorferi-induced Production of Interleukin-1β (IL-1β)* (2013) (25)
- Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses (2018) (23)
- ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection (2022) (23)
- Addendum: Defective Dock2 expression in a subset of ASC-deficient mouse lines (2012) (23)
- Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae (2019) (22)
- IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever. (2017) (22)
- Distinct role of IL-1β in instigating disease in Sharpincpdm mice (2016) (21)
- Innate immune recognition of mtDNA--an undercover signal? (2015) (21)
- Role of inflammasomes/pyroptosis and PANoptosis during fungal infection (2021) (21)
- PANoptosis components, regulation, and implications (2020) (21)
- A comprehensive guide to studying inflammasome activation and cell death (2020) (20)
- Pyroptosis in Antiviral Immunity. (2019) (20)
- In planta expression of oomycete and fungal genes. (2007) (20)
- Inflammasome-derived IL-1{beta} regulates the production of GM-CSF by CD4+ T cells and {gamma}{delta} T cells (2012) (19)
- The inflammasome: A remote control for metabolic syndrome (2012) (19)
- Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance (2017) (19)
- K⁺ drops tilt the NLRP3 inflammasome. (2013) (19)
- The innate immune system and cell death in autoinflammatory and autoimmune disease. (2020) (19)
- SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses (2014) (18)
- IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death (2020) (17)
- PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field (2021) (17)
- DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection (2016) (16)
- Inflammasomes and Intestinal Tumorigenesis. (2011) (16)
- DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response (2021) (16)
- Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile? (2017) (16)
- The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression (2017) (16)
- ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. (2018) (16)
- ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease (2020) (15)
- It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects (2022) (15)
- Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics (2017) (14)
- Zα2 domain of ZBP1 is a molecular switch regulating Influenza-induced PANoptosis and perinatal lethality during development (2020) (14)
- Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease (2022) (14)
- Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells (2019) (12)
- Stressed-out ROS take a silent death route (2018) (12)
- Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion (2020) (11)
- DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells. (2020) (10)
- Targeting NLRP6 to enhance immunity against bacterial infections. (2012) (10)
- A20 is a regulator of necroptosis (2015) (10)
- PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality (2022) (10)
- Hidden Aspects of Valency in Immune System Regulation. (2019) (9)
- Fat chance: not much against NKT cells. (2012) (9)
- RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling (2020) (9)
- Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi (2016) (9)
- Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease (2016) (9)
- A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma (2021) (8)
- Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection (2020) (8)
- Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense (2020) (8)
- Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax (2022) (8)
- Drak2 is not required for tumor surveillance and suppression. (2015) (8)
- Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection (2021) (7)
- NLRP12 in autoimmune diseases (2015) (7)
- The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis (2019) (7)
- Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles. (2020) (7)
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). (2020) (7)
- Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice (2019) (7)
- Mechanisms and Consequences of Inflammasome Activation. (2018) (7)
- The nonreceptor tyrosine kinase SYK induces autoinflammatory osteomyelitis in a mouse model of chronic recurrent multifocal osteomyelitis. (2019) (6)
- Critical role for inflammasome-independent IL-1{beta} production in osteomyelitis (P6211) (2013) (6)
- Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections (2021) (6)
- The inflammasome starts rolling (2018) (6)
- Fueling Ketone Metabolism Quenches Salt-Induced Hypertension (2019) (6)
- Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation (2020) (5)
- Immune Responses in Mesothelial Cells Chemokine and Antimicrobial Innate Nod 1 / RICK and TLR Signaling Regulate (2007) (5)
- Innate Immune Pathways in Host Defense (2012) (5)
- The signposts and winding roads to immunity and inflammation (2019) (5)
- Inflammasome signaling in colorectal cancer. (2022) (5)
- CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes (2021) (5)
- Targeting Apoptosis Inhibition to Activate Antitumor Immunity. (2019) (5)
- Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method (2022) (4)
- Fostering experimental and computational synergy to modulate hyperinflammation (2021) (4)
- Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis (2021) (4)
- Amendment history : Corrigendum ( June 2015 ) MHCII-independent CD 4 + T cells protect injured CNS neurons via IL-4 (2019) (4)
- Innate immunity, cytokine storm, and inflammatory cell death in COVID-19 (2022) (4)
- Fungal cell wall components modulate our immune system (2021) (4)
- DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome (2019) (4)
- DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease (2022) (4)
- Food for Training-Western Diet and Inflammatory Memory. (2018) (4)
- The Nlrp3 inflammasome in IBD and colorectal tumorigenesis (2011) (4)
- Sepsis take-out: Inhibiting bacterial deliveries. (2021) (3)
- HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells (2019) (3)
- Critical role for the NLRP3 inflammasome in colitis and colitis associated colorectal cancer (47.9) (2010) (3)
- Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions (2019) (3)
- Caspase-1 Activation Growth Independently of pneumophila Legionella Naip 5 / Birc 1 e Restricts The Nod-Like Receptor Family Member (2007) (3)
- Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease? (2018) (3)
- Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy (2021) (3)
- NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis (2022) (2)
- TLR and IKK Complex–Mediated Innate Immune Signaling Inhibits Stress Granule Assembly (2021) (2)
- SHORT COMMUNICATION IL-1 b and Caspase-1 Drive Autoin fl ammatory Disease Independently of IL-1 a or Caspase-8 in a Mouse Model of Familial Mediterranean Fever (2017) (2)
- Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease (2014) (2)
- Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver (2021) (2)
- Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis (2010) (2)
- Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa (2018) (2)
- Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation (2022) (1)
- Inflammasome-independent role of AIM2 in mediating protection against colorectal tumorogenesis (2016) (1)
- NOD-Like Receptors in Colon Tumorigenesis (2013) (1)
- Pathogen's dynamic standoff with the host. (2021) (1)
- NLRC5 regulates MHC-I expression and immunity during viral infection (APP3P.101) (2015) (1)
- The NLRP 12 Sensor Nega tively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells Highlights (1)
- The IFN‐inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice (2021) (1)
- Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology (2022) (1)
- MyD88 mediates the pathogenesis of dermatitis in SHARPIN-deficient mice by regulating TNF production on the skin (2019) (1)
- Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease (2021) (1)
- Alarmin HMGB 1 in Endotoxemia Inflammasome-Dependent Release of the Dixit (2010) (1)
- Novel role for inflammasome-dependent IL-18 in promoting Th2 responses during Leishmania infections (IRC7P.420) (2015) (1)
- Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression (2022) (1)
- Autophagy is redundant for the host defense against systemic Candida albicans infections (2013) (1)
- War on Viruses: LC3 Recruits GTPases. (2017) (1)
- ADAR1 and ZBP1 in innate immunity, cell death, and disease. (2023) (1)
- The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis (2022) (1)
- It’s just a phase: NLRP6 phase separations drive signaling (2021) (1)
- cGAMP: A tale of two signals (2017) (1)
- Humans pIKK-up NLRP3 to skip NEK7. (2022) (1)
- Rising to the challenge of COVID-19: Working on SARS-CoV-2 during the pandemic (2021) (1)
- The NLRC4 inflammasome requires IRF8-dependent production of NAIPs (2018) (1)
- Z-DNA binding protein 1 (ZBP1) is an innate sensor of Influenza vRNPs and activates programmed cell death and assembly of NLRP3 inflammasome (2018) (1)
- Chitin recognition in fungal infections and its impact on the immune response (2013) (1)
- Innate sensing pathways: Defining new innate immune and inflammatory cell death pathways has shaped translational applications (2023) (0)
- TLR7/8 Differentially Regulates Fcγ Receptor Expression and Function. (2009) (0)
- Caspase-1, but not ASC or NLRP3 inflammasome components, mediates IL-1beta activation and antifungal defense in disseminated candidiasis (2009) (0)
- Targeting apoptosis inhibition to activate anti-tumor immune responses (2020) (0)
- Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease. (2023) (0)
- The Role of RIP2 in Experimental Colitis: P‐253 (2012) (0)
- Integrated stress response restricts macrophage necroptosis (2021) (0)
- FADD and caspase-8 mediate priming and activation of the canonical and non-canonical Nlrp3 inflammasomes (INC5P.321) (2014) (0)
- Mechanism of Influenza Virus Induced Inflammatory Cell Death (2019) (0)
- How caspase-7 controls intracellular infection in macrophages (134.86) (2009) (0)
- Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection (2020) (0)
- Stressed-out ROS take a silent death route (2018) (0)
- On the Road to Discovering the Elusive Executioner of Pyroptosis (2019) (0)
- Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice (2018) (0)
- Inflammasome-Dependent Release of the Dixit (2010) (0)
- Evaluation of Caspase Activation to Assess Innate Immune Cell Death. (2023) (0)
- Caspase-1 and ASC but not NLRP3 mediate antifungal defense in candidiasis sepsis (2009) (0)
- Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation (2022) (0)
- Critical role of ASK signaling in promoting inflammatory disease in Ptpn6spin mice (2018) (0)
- This information is current as and AIM 2 Sensor Type I IFN Pathway − STING − cGAS / IFI 16 Canarypox Virus Vector ALVAC via the Priming and Activation of Inflammasome by Sun (2017) (0)
- This information is current as Colorectal Tumor Formation Inflammasome Confers Protection against IL-18 Production Downstream of the Nlrp 3 (2010) (0)
- Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection (2018) (0)
- Activation Extracellular Signal-regulated Kinase via Listeria monocytogenes Autophagy of TLR 2 and RIP 2 Pathways Mediate Immunology : (2011) (0)
- Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection (2020) (0)
- Guanylate-binding proteins and other interferon-inducible proteins are essential for the activation of the inflammasomes (2016) (0)
- DDX3X Cellular Valency Allows Stressed Cells to Make a Live or Die Cell Fate Decision by Regulating Stress Granules and the NLRP3 Inflammasome (2020) (0)
- Interplay between type I interferon signaling and AIM2 inflammasome in Francisella novicida infection (2018) (0)
- CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation (2023) (0)
- Diverging inflammasome signals in tumorigenesis and potential targeting (2019) (0)
- Specific role of IL-1β in instigating skin inflammation in Sharpin-deficient mice (2017) (0)
- STING protects against colitis-associated colorectal tumorigenesis by modulating intestinal inflammation (TUM7P.1018) (2015) (0)
- The Role of Inflammasomes in Viral Infection (2011) (0)
- Poly(ADP-Ribose) Polymerase 1 by the Cutting Edge: Proteolytic Inactivation of (0)
- Cancer Immunology at the Crossroads In fl ammasomes and Cancer (2017) (0)
- P-227 NLRP12 Dampens Host Defense Responses Against Bacterial Gastroenteritis (2013) (0)
- IRF8 regulated interferon beta production drives Gram-negative bacteria-mediated NLRP3 inflammasome activation (2020) (0)
- Autophagy of Listeria monocytogenes within macrophages is dependent on Nod/Rip2 pathway (157.2) (2011) (0)
- IRF1 regulates apoptotic caspases to thwart the development of colorectal cancer (2020) (0)
- Galactosaminogalactan activates the inflammasome to provide host protection (2020) (0)
- Regulators of Inflammatory Responses (2019) (0)
- The signposts and winding roads to immunity and inflammation (2019) (0)
- Opposing roles of AIM2 inflammasome and type I interferon signaling in Francisella infection (2016) (0)
- Cobalt-chrome micro-particles induce a robust MyD88-independent, Caspase1-dependent type 2 immune response (P1266) (2013) (0)
- Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice (2019) (0)
- Cobalt-chrome micro-particles induce a robust MyD88-independent type 2 immune response (IRM7P.495) (2014) (0)
- Type I Interferon Keeps IL-1β in Check. (2016) (0)
- AIM2 and NLRP3 inflammasome activation provide dual surveillance to confer protection against Aspergillus infection (MPF4P.728) (2015) (0)
- A BAF-fling connection to RIPK1 (2022) (0)
- Noncanonical Nlrp3 Inflammasomes Activation of the Canonical and FADD and Caspase-8 Mediate Priming and (0)
- Intestinal tête-à-tête: helminths blunt immunity against flaviviruses (2021) (0)
- Nod1 deficiency inhibits autophagy against Salmonella typhimurium in macrophages (136.21) (2010) (0)
- The inflammasome starts rolling (2018) (0)
- Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. (2023) (0)
- Deficiency in SHP-1 triggers a cutaneous autoinflammatory disease that is provoked by IL-1α (P4071) (2013) (0)
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors (2016) (0)
- Rip2 plays a critical role in regulating intestinal inflammation (166.8) (2011) (0)
- Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics (2017) (0)
- in Diverse Cancer Lineages Inhibits Tumor Growth Inflammatory Cell Death, PANoptosis, Mediated by Cytokines (2021) (0)
- Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation (2017) (0)
- Mechanisms Regulating IL-1β Mediated Inflammation during Secondary Bacterial Pneumonia (2018) (0)
- Inflammasome regulates host immune responses to enteric pathogen (P4237) (2013) (0)
- Genetic deficiency of NOD2 confers resistance to invasive aspergillosis (2018) (0)
- PARP-1 regulates pro-inflammatory cell death (34.13) (2010) (0)
- AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes. (2023) (0)
- Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
- Commensal gut fungi regulate susceptibility to colitis and colorectal cancer. (2018) (0)
- Toward targeting inflammasomes: insights into their regulation and activation (2020) (0)
- Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines (2022) (0)
- The Role Of The Inflammasome And The Apoptosome In The Control Of Pulmonary Pathogens (2010) (0)
- Critical Role for NLRC3 in Cell Proliferation and Cancer (2017) (0)
- NLRP12 negatively regulates autoinflammatory disease by modulating T cell responses and IL-4 production (BA6P.133) (2015) (0)
- ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence (2023) (0)
- Critical role of TRIF in modulating innate and adaptive responses during Citrobacter rodentium infection. (P4037) (2013) (0)
- Immunity to virus infection (excluding retroviruses) 2 (WS-025b) Chairpersons: Tsukasa Seya, Iain Campbell (2010) (0)
- PARP-1 regulates pro-inflammatory cell death (2010) (0)
- SHARPIN, a novel regulator of the NLRP3 inflammasome (INM6P.334) (2015) (0)
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