Thomas C. Südhof
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German biochemist
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Thomas C. Südhofbiology Degrees
Biology
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#109
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Neuroscience
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Biochemistry
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Biology
Thomas C. Südhof's Degrees
- Masters Medicine University of Göttingen
- PhD Neurochemistry University of Göttingen
Why Is Thomas C. Südhof Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thomas Christian Südhof , ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the school of medicine in the department of molecular and cellular physiology, and by courtesy in neurology, and in psychiatry and behavioral sciences at Stanford University.
Thomas C. Südhof's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Direct conversion of fibroblasts to functional neurons by defined factors (2010) (2789)
- The synaptic vesicle cycle: a cascade of proteinprotein interactions (1995) (1988)
- Membrane Fusion: Grappling with SNARE and SM Proteins (2009) (1855)
- Neuroligins and neurexins link synaptic function to cognitive disease (2008) (1590)
- Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse (1994) (1450)
- Membrane Fusion (2003) (1398)
- α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro (2010) (1383)
- Synaptic assembly of the brain in the absence of neurotransmitter secretion. (2000) (1299)
- The synaptic vesicle cycle (2004) (1292)
- The synaptic vesicle cycle. (2004) (1211)
- Membrane fusion and exocytosis. (1999) (1210)
- Induction of human neuronal cells by defined transcription factors (2011) (1151)
- Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25 (1993) (1145)
- A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 (2001) (1111)
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells (2013) (996)
- Synaptotagmin I functions as a calcium regulator of release probability (2001) (939)
- Synaptotagmin: a calcium sensor on the synaptic vesicle surface. (1992) (917)
- A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice (2007) (907)
- Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013) (871)
- The Presynaptic Active Zone (2012) (837)
- α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration (2005) (834)
- Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C (1990) (798)
- SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly (2002) (787)
- C2-domains, Structure and Function of a Universal Ca2+-binding Domain* (1998) (784)
- Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. (1994) (784)
- Neuroligins Determine Synapse Maturation and Function (2006) (776)
- The LDL receptor gene: a mosaic of exons shared with different proteins. (1985) (751)
- A conformational switch in syntaxin during exocytosis: role of munc18 (1999) (738)
- Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin (1993) (733)
- Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles (1999) (724)
- Binding of neuroligins to PSD-95. (1997) (719)
- Essential functions of synapsins I and II in synaptic vesicle regulation (1995) (712)
- Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion (1997) (689)
- Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold (1995) (671)
- Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. (1992) (668)
- Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. (1999) (665)
- SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice (2001) (645)
- RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone (2002) (618)
- Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins (1995) (616)
- Snares and munc18 in synaptic vesicle fusion (2002) (567)
- α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis (2003) (562)
- Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2 (2007) (550)
- A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. (2001) (549)
- Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009) (543)
- Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. (2005) (541)
- A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain (1998) (537)
- RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction (2011) (531)
- Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. (2005) (517)
- RIBEYE, a Component of Synaptic Ribbons A Protein's Journey through Evolution Provides Insight into Synaptic Ribbon Function (2000) (516)
- A Neural Circuit for Memory Specificity and Generalization (2013) (508)
- Proteins of synaptic vesicles involved in exocytosis and membrane recycling (1991) (507)
- Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (2013) (504)
- Synaptotagmins: Why So Many?* (2002) (497)
- Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor (1989) (490)
- Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein (1993) (487)
- Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling (1994) (487)
- β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs (2002) (480)
- Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. (1989) (476)
- Complexins: Cytosolic proteins that regulate SNAP receptor function (1995) (474)
- The role of Rab3A in neurotransmitter release (1994) (468)
- Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits (2017) (463)
- Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release (2001) (462)
- A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis (2006) (452)
- Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic (1996) (445)
- A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. (1993) (445)
- Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins (*) (1996) (439)
- Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons (1995) (438)
- Postsynaptic membrane fusion and long-term potentiation. (1998) (433)
- Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells (2012) (432)
- A stoichiometric complex of neurexins and dystroglycan in brain (2001) (425)
- rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. (1990) (423)
- Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. (1994) (419)
- Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release (1998) (418)
- Three-Dimensional Structure of the Complexin/SNARE Complex (2002) (417)
- Nicastrin Functions as a γ-Secretase-Substrate Receptor (2005) (413)
- The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion (1997) (413)
- Neuroligin 1: A splice site-specific ligand for β-neurexins (1995) (411)
- Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments (2009) (409)
- Munc18-1 Promotes Large Dense-Core Vesicle Docking (2001) (404)
- A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins (2005) (403)
- A small GTP-binding protein dissociates from synaptic vesicles during exocytosis (1991) (402)
- Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. (1985) (399)
- Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior (2010) (399)
- Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region (1987) (392)
- Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. (2004) (389)
- A Broken α-Helix in Folded α-Synuclein* (2003) (389)
- Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins (*) (1995) (383)
- Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. (1990) (383)
- The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? (2012) (380)
- Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain Synaptotagmin 1 as a Phospholipid Binding Machine (2001) (379)
- Neurexins: three genes and 1001 products. (1998) (371)
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation (2014) (368)
- Synaptic vesicles and exocytosis. (1994) (366)
- Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors (2014) (360)
- Synapses and Alzheimer's disease. (2012) (354)
- Calcium control of neurotransmitter release. (2012) (354)
- A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (2007) (354)
- Munc18-1 binds directly to the neuronal SNARE complex (2007) (347)
- RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone (2011) (346)
- Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion (2009) (343)
- Towards an Understanding of Synapse Formation (2018) (340)
- Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. (1986) (339)
- Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. (2011) (339)
- SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release (1999) (338)
- Cell biology of Ca2+-triggered exocytosis. (2010) (332)
- Structure of a novel InsP3 receptor. (1991) (329)
- ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion (2017) (329)
- SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse (2019) (328)
- A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis (2012) (328)
- Neuroligin 1: a splice site-specific ligand for beta-neurexins. (1995) (327)
- LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation (2009) (327)
- Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons (1992) (326)
- Domain structure of synaptotagmin (p65) (1991) (326)
- Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A (1998) (325)
- Association of Neuronal Calcium Channels with Modular Adaptor Proteins* (1999) (321)
- Short-term synaptic plasticity is altered in mice lacking synapsin I (1993) (319)
- Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation* (2004) (319)
- Membrane fusion machinery: Insights from synaptic proteins (1993) (318)
- Essential Roles in Synaptic Plasticity for Synaptogyrin I and Synaptophysin I (1999) (311)
- Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq. (2016) (310)
- The ligand binding site and transduction mechanism in the inositol‐1,4,5‐triphosphate receptor. (1990) (305)
- A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins* (1998) (304)
- Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis. (1992) (303)
- Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1 (2014) (302)
- Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons (2007) (301)
- Bipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C (1996) (299)
- Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain? (1998) (291)
- Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function (2011) (290)
- Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. (1992) (289)
- A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. (1987) (286)
- Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis (1991) (285)
- Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product (1992) (284)
- A Complete Genetic Analysis of Neuronal Rab3 Function (2004) (283)
- Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion (2008) (282)
- RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. (1998) (281)
- Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. (2002) (279)
- Synaptic vesicle exocytosis. (2011) (279)
- The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones (2014) (278)
- Phosphorylation of Munc-18/n-Sec1/rbSec1 by Protein Kinase C (1996) (274)
- Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3. (1994) (274)
- RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13 (2011) (268)
- A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? (2005) (267)
- Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities (2002) (267)
- Presenilins are Essential for Regulating Neurotransmitter Release (2009) (267)
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 (2013) (265)
- Properties of native brain α-synuclein (2013) (260)
- RIM1α is required for presynaptic long-term potentiation (2002) (259)
- Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons (1991) (258)
- Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin. (1994) (258)
- A Phospho-Switch Controls the Dynamic Association of Synapsins with Synaptic Vesicles (1999) (258)
- Synaptotagmin-1 functions as the Ca2+-sensor for spontaneous release (2009) (256)
- Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing (2014) (256)
- Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids (2006) (255)
- CASK Functions as a Mg2+-Independent Neurexin Kinase (2008) (255)
- Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. (1996) (255)
- A synaptic vesicle membrane protein is conserved from mammals to Drosophila (1989) (254)
- Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals (1993) (252)
- A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones (2002) (251)
- Cell Biology and Pathophysiology of α-Synuclein. (2018) (249)
- Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis (2015) (247)
- Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release (2013) (246)
- The Synaptic VesicleCycle Revisited (2000) (245)
- Synaptobrevin is essential for fast synaptic-vesicle endocytosis (2004) (243)
- Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis (1991) (240)
- A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. (2005) (240)
- Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons (2016) (239)
- Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling (2013) (237)
- Autonomous Function of Synaptotagmin 1 in Triggering Synchronous Release Independent of Asynchronous Release (2005) (237)
- Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α (2007) (236)
- Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking (2013) (236)
- Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses (2003) (234)
- The Synaptic Vesicle Protein CSPα Prevents Presynaptic Degeneration (2004) (233)
- Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. (1988) (233)
- Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis (2001) (232)
- Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch (1997) (229)
- Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. (1991) (228)
- The RIM/NIM Family of Neuronal C2 Domain Proteins (2000) (224)
- Binding Properties of Neuroligin 1 and Neurexin 1β Reveal Function as Heterophilic Cell Adhesion Molecules* (1997) (224)
- Nicastrin functions as a gamma-secretase-substrate receptor. (2005) (223)
- v‐SNAREs control exocytosis of vesicles from priming to fusion (2005) (220)
- Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. (2002) (219)
- Association of Rab3A with synaptic vesicles at late stages of the secretory pathway (1991) (218)
- Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? (1998) (218)
- Mints, Munc18-interacting Proteins in Synaptic Vesicle Exocytosis* (1997) (216)
- Generation of pure GABAergic neurons by transcription factor programming (2017) (215)
- CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity (2011) (213)
- Synaptic cell adhesion. (2012) (212)
- Synaptotagmin II. A novel differentially distributed form of synaptotagmin. (1991) (211)
- Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1* (2004) (211)
- Selective Capability of SynCAM and Neuroligin for Functional Synapse Assembly (2005) (208)
- SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family (1999) (206)
- Synaptotagmin-2 Is Essential for Survival and Contributes to Ca2+ Triggering of Neurotransmitter Release in Central and Neuromuscular Synapses (2006) (205)
- A Trimeric Protein Complex Functions as a Synaptic Chaperone Machine (2001) (204)
- Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I (2001) (204)
- Deletion of CASK in mice is lethal and impairs synaptic function (2007) (203)
- Functional properties of multiple synaptotagmins in brain (1994) (203)
- alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. (2001) (200)
- How Tlg2p/syntaxin 16 'snares’ Vps45 (2002) (198)
- Rab proteins in regulated exocytosis. (1994) (197)
- Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells (2008) (195)
- Increased anxiety‐like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2 (2009) (195)
- Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1β Complex Reveal Specific Protein-Protein and Protein-Ca2+ Interactions (2007) (192)
- Munc13 C2B-Domain – an Activity-Dependent Ca2+-Regulator of Synaptic Exocytosis (2010) (192)
- Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C (1994) (191)
- LTP Requires a Unique Postsynaptic SNARE Fusion Machinery (2013) (190)
- C 2-domains , Structure and Function of a Universal Ca 2 1-binding Domain * (1998) (189)
- Impaired learning in mice with abnormal short-lived plasticity (1996) (189)
- Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage (2004) (189)
- Propagation of prions causing synucleinopathies in cultured cells (2015) (188)
- Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle. (1999) (187)
- Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. (1998) (186)
- Differential expression and regulation of multiple dynamins. (1994) (186)
- The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis (2017) (186)
- A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins. (1995) (185)
- Induced neuronal cells: how to make and define a neuron. (2011) (185)
- The Appendage Domain of α-Adaptin Is a High Affinity Binding Site for Dynamin (*) (1995) (184)
- Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity -SNAP Binding Site (*) (1995) (183)
- The synaptic vesicle cycle revisited. (2000) (182)
- gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. (1990) (182)
- Mints as Adaptors (2000) (182)
- Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development (2012) (182)
- Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis (2010) (181)
- Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release (2006) (178)
- 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter (1987) (177)
- Molecular determinants of regulated exocytosis. (2002) (176)
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice (2008) (175)
- E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains (2007) (175)
- DOC2 Proteins in Rat Brain: Complementary Distribution and Proposed Function as Vesicular Adapter Proteins in Early Stages of Secretion (1997) (174)
- alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. (1998) (173)
- A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export (2009) (172)
- A molecular machine for neurotransmitter release: synaptotagmin and beyond (2013) (172)
- Multiple Roles for the Active Zone Protein RIM1α in Late Stages of Neurotransmitter Release (2004) (171)
- A Role for cAMP in Long-Term Depression at Hippocampal Mossy Fiber Synapses (1998) (171)
- RIM1alpha is required for presynaptic long-term potentiation. (2002) (170)
- Selective Interaction of Complexin with the Neuronal SNARE Complex (2000) (168)
- Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming (2009) (168)
- cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map (2007) (168)
- Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-Term Synaptic Plasticity (2006) (167)
- Rabphilin Knock-Out Mice Reveal That Rabphilin Is Not Required for Rab3 Function in Regulating Neurotransmitter Release (1999) (167)
- Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. (2015) (167)
- Localization Versus Function of Rab3 Proteins (2002) (166)
- CASK and Protein 4.1 Support F-actin Nucleation on Neurexins* (2001) (165)
- Interaction of synaptotagmin with the cytoplasmic domains of neurexins (1993) (164)
- Neuroligin-2 Deletion Selectively Decreases Inhibitory Synaptic Transmission Originating from Fast-Spiking but Not from Somatostatin-Positive Interneurons (2009) (164)
- EHSH1/Intersectin, a Protein That Contains EH and SH3 Domains and Binds to Dynamin and SNAP-25 (1999) (163)
- Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission (2012) (161)
- Comprehensive qPCR profiling of gene expression in single neuronal cells (2011) (161)
- The Making of Neurexins (1998) (161)
- A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans* (2001) (160)
- Cassette of eight exons shared by genes for LDL receptor and EGF precursor. (1985) (156)
- Neurexins Physically and Functionally Interact with GABAA Receptors (2010) (155)
- Dissection of Synapse Induction by Neuroligins (2005) (155)
- Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates (2017) (155)
- Vam3p structure reveals conserved and divergent properties of syntaxins (2001) (155)
- The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. (2004) (155)
- Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus (2007) (154)
- Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins. (1994) (154)
- High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex* (2012) (154)
- SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis (2009) (152)
- Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion (2006) (152)
- SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning (2010) (152)
- Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. (1987) (152)
- Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. (1994) (149)
- Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix (2010) (148)
- The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory (2004) (146)
- Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons (2016) (146)
- Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1. (2005) (146)
- Definition of a Molecular Pathway Mediating α-Synuclein Neurotoxicity (2015) (145)
- Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins (2013) (144)
- Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines (2007) (143)
- Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins (2017) (143)
- Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. (1996) (142)
- Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities (2012) (142)
- The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins (2011) (142)
- Understanding Synapses: Past, Present, and Future (2008) (141)
- Histogenesis and differentiation potential of central neurocytomas. (1991) (141)
- Cell biology of Ca 2+ -triggered exocytosis (2010) (139)
- Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells. (1989) (139)
- Inositol 1,4,5-Trisphosphate receptor causes formation of ER cisternal stacks in transfected fibroblasts and in cerebellar purkinje cells (1994) (138)
- The Evolutionary Pressure to Inactivate (1997) (138)
- The molecular machinery of neurotransmitter release (Nobel lecture). (2014) (138)
- CSPα knockout causes neurodegeneration by impairing SNAP‐25 function (2012) (137)
- Doc2 Supports Spontaneous Synaptic Transmission by a Ca2+-Independent Mechanism (2011) (137)
- Climate change and the integrity of science. (2010) (137)
- Isolation of mammalian calelectrins: a new class of ubiquitous Ca2+-regulated proteins. (1984) (137)
- Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation (2007) (135)
- Distinct Ca2+ and Sr2+ Binding Properties of Synaptotagmins (1995) (135)
- Transmembrane topography and evolutionary conservation of synaptophysin. (1989) (135)
- Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+ Channels (2005) (135)
- Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. (1993) (134)
- The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo (2011) (134)
- Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins (2019) (133)
- Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules (2002) (131)
- Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway. (1994) (130)
- Neuroligin‐1 performs neurexin‐dependent and neurexin‐independent functions in synapse validation (2009) (130)
- Annexin VI is required for budding of clathrin-coated pits (1992) (130)
- Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. (2006) (129)
- Sr2+ Binding to the Ca2+ Binding Site of the Synaptotagmin 1 C2B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions (2003) (129)
- Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP (2017) (128)
- An autism‐associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus (2011) (127)
- Structure/Function Analysis of Ca2+ Binding to the C2A Domain of Synaptotagmin 1 (2002) (127)
- Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. (2004) (127)
- Distinct Ca-dependent Properties of the First and Second C-domains of Synaptotagmin I (*) (1996) (126)
- Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+ (2003) (125)
- Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (2003) (125)
- Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. (1990) (125)
- Divergent Functions of Neuronal Rab11b in Ca2+-Regulated versus Constitutive Exocytosis (2003) (124)
- Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. (2004) (124)
- The C2B domain of synaptotagmin I is a Ca2+-binding module. (2001) (123)
- A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides (2008) (122)
- Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion (2012) (122)
- Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles. (2000) (122)
- Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission. (2007) (122)
- Role of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice (2003) (122)
- A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca2+-Dependent Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis (2006) (121)
- CASK Participates in Alternative Tripartite Complexes in which Mint 1 Competes for Binding with Caskin 1, a Novel CASK-Binding Protein (2002) (121)
- Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006) (121)
- Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β* (2003) (121)
- Regulation of LNS Domain Function by Alternative Splicing: The Structure of the Ligand-Binding Domain of Neurexin Iβ (1999) (120)
- Dynamic Binding Mode of a Synaptotagmin-1-SNARE Complex in Solution (2015) (120)
- Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms (2015) (119)
- Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP (2010) (119)
- Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation (2006) (118)
- Synapsin I is structurally similar to ATP‐utilizing enzymes (1998) (118)
- Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP (2012) (117)
- Mechanism of Action of rab3A in Mossy Fiber LTP (1998) (117)
- Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1* (2006) (116)
- Phosphorylation of dynamin I and synaptic-vesicle recycling (1994) (116)
- Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10 (2011) (115)
- Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. (1998) (114)
- Membrane fusion. (2003) (114)
- Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses (1999) (113)
- How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs (2016) (112)
- The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice (2001) (111)
- MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development (2012) (110)
- Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. (2004) (110)
- Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses (2015) (109)
- Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump. (1991) (109)
- Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch (2006) (108)
- Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor. (1992) (108)
- Rabphilin regulates SNARE‐dependent re‐priming of synaptic vesicles for fusion (2006) (108)
- Calmodulin Controls Synaptic Strength via Presynaptic Activation of Calmodulin Kinase II (2010) (106)
- Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release (2007) (106)
- Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release (2013) (105)
- Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms (2002) (104)
- Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins (2002) (103)
- Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family (2006) (103)
- ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses (2009) (102)
- Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release (2009) (102)
- Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas (2009) (102)
- β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling (2015) (101)
- Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal (1993) (101)
- Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ (2013) (101)
- Munc18–1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation (2005) (101)
- Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons (2011) (100)
- Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis (2008) (100)
- RIM genes differentially contribute to organizing presynaptic release sites (2012) (100)
- First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. (1987) (99)
- A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission (2003) (99)
- Synapsins I and II Are ATP-binding Proteins with Differential Ca2+ Regulation* (1998) (98)
- Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4 (2004) (98)
- Neurexophilins Form a Conserved Family of Neuropeptide-Like Glycoproteins (1998) (98)
- Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties* (2005) (98)
- A conformational switch in the Piccolo C2A domain regulated by alternative splicing (2004) (98)
- Deletion of α‐neurexins does not cause a major impairment of axonal pathfinding or synapse formation (2007) (97)
- N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1 (2004) (97)
- Synaptogyrins Regulate Ca2+-dependent Exocytosis in PC12 Cells* (1999) (95)
- Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C. (1994) (95)
- The structure of the human synapsin I gene and protein. (1990) (95)
- SCAMP1 Function in Endocytosis* (2000) (95)
- Neurexin Iα Is a Major α-Latrotoxin Receptor That Cooperates in α-Latrotoxin Action* (1998) (94)
- Structure and Evolution of Neurexophilin (1996) (93)
- The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization. (1990) (93)
- How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release (2016) (92)
- Neurexins Are Functional α-Latrotoxin Receptors (1999) (92)
- Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse (2018) (91)
- Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments (2015) (91)
- Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses (2017) (91)
- RIM1α and RIM1β Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions (2008) (89)
- Distribution of synaptic markers in the retina: Implications for synaptic vesicle traffic in ribbon synapses (1994) (89)
- Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling (2003) (88)
- Region-Specific Phosphorylation of Rabphilin in Mossy Fiber Nerve Terminals of the Hippocampus (1998) (88)
- SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles (1998) (88)
- rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence (1991) (87)
- Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. (2015) (87)
- Homo- and Heterodimerization of Synapsins* (1999) (87)
- Human endomembrane H+ pump strongly resembles the ATP-synthetase of Archaebacteria. (1989) (87)
- The Subcellular Localizations of Atypical Synaptotagmins III and VI (1999) (87)
- Synapsin III, a Novel Synapsin with an Unusual Regulation by Ca2+ * (1998) (87)
- RIM function in short- and long-term synaptic plasticity. (2005) (86)
- RIM-BPs Mediate Tight Coupling of Action Potentials to Ca2+-Triggered Neurotransmitter Release (2015) (86)
- Evolution of CASK into a Mg2+-Sensitive Kinase (2010) (86)
- Unusually rapid evolution of Neuroligin-4 in mice (2008) (86)
- Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells (2002) (85)
- Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane-Trafficking Functions (2000) (85)
- Synaptotagmin Regulation of Coated Pit Assembly* (2000) (85)
- Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes (2013) (85)
- Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses (2015) (84)
- NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin (1999) (83)
- Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. (1998) (83)
- Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse (2017) (82)
- Characterization of tissue-specific transcription by the human synapsin I gene promoter. (1991) (82)
- α‐Latrotoxin action probed with recombinant toxin: receptors recruit α‐latrotoxin but do not transduce an exocytotic signal (1998) (82)
- C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+ Triggering of Synaptic Exocytosis (2012) (81)
- RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning (2008) (81)
- Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. (2005) (80)
- Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings. (2000) (79)
- CSPα-deficiency causes massive and rapid photoreceptor degeneration (2006) (79)
- Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. (2006) (79)
- Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α (2007) (79)
- Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. (2003) (79)
- Structure of synaptogyrin (p29) defines novel synaptic vesicle protein (1995) (78)
- Neurotransmitter Release at the Thalamocortical Synapse Instructs Barrel Formation But Not Axon Patterning in the Somatosensory Cortex (2012) (77)
- cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. (1993) (76)
- Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration (2009) (76)
- Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses (2019) (75)
- The structure of cytochrome b561, a secretory vesicle‐specific electron transport protein. (1988) (75)
- The G Protein-coupled Receptor CL1 Interacts Directly with Proteins of the Shank Family* (2000) (75)
- Calcium regulation of neurotransmitter release: reliably unreliable? (1997) (75)
- Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties (2017) (75)
- Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins. (1988) (74)
- Membrane-Tethered Monomeric Neurexin LNS-Domain Triggers Synapse Formation (2013) (74)
- Push-and-pull regulation of the fusion pore by synaptotagmin-7 (2010) (74)
- Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle (1994) (73)
- Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation (2013) (73)
- Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. (2014) (73)
- Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. (2006) (73)
- Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles (2015) (73)
- Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment (2019) (72)
- Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand (2017) (71)
- Structure of the Janus-faced C2B domain of rabphilin (1999) (70)
- Phosphorylation of synaptotagmin I by casein kinase II. (1993) (70)
- Direct Interaction of Alzheimer’s Disease-related Presenilin 1 with Armadillo Protein p0071* (1999) (69)
- The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling (2018) (69)
- Long-term potentiation in mice lacking synapsins (1995) (69)
- Ca(2+)-dependent conformational change in synaptotagmin I. (1994) (69)
- Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. (1996) (68)
- Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism (2016) (67)
- The Active Zone Protein Family ELKS Supports Ca2+ Influx at Nerve Terminals of Inhibitory Hippocampal Neurons (2014) (66)
- The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing. (1999) (66)
- Common EF‐hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations (2008) (66)
- Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. (2005) (66)
- Analysis of conditional heterozygous STXBP1 mutations in human neurons. (2015) (65)
- Differential distributions of novel synaptotagmins: Comparison to synapsins (1995) (65)
- Deletion of Mint Proteins Decreases Amyloid Production in Transgenic Mouse Models of Alzheimer's Disease (2008) (64)
- Ca 2 binding to synaptotagmin : how many Ca 2 ions bind to the tip of a C 2-domain ? (2013) (64)
- Functional Analysis of Conserved Structural Elements in Yeast Syntaxin Vam3p* (2001) (64)
- Cellugyrin, a Novel Ubiquitous Form of Synaptogyrin That Is Phosphorylated by pp60c- src * (1998) (64)
- Function of Rab3 GDP–GTP Exchange (1997) (64)
- Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning (2011) (64)
- Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly (2017) (63)
- Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms (2015) (63)
- High Affinity Binding of α-Latrotoxin to Recombinant Neurexin Iα (*) (1995) (62)
- Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation (2013) (62)
- Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons (2019) (62)
- Cellular distribution of three mammalian Ca2+‐binding proteins related to Torpedo calelectrin. (1984) (62)
- Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration (2012) (62)
- CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity (2011) (62)
- Continuous and Discrete Neuron Types of the Adult Murine Striatum (2019) (61)
- Microsecond Dissection of Neurotransmitter Release: SNARE-Complex Assembly Dictates Speed and Ca2+ Sensitivity (2014) (61)
- Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters (2019) (61)
- Transdifferentiation of human adult peripheral blood T cells into neurons (2018) (61)
- The cell biology of synapse formation (2021) (60)
- The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. (1986) (60)
- Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells (2015) (59)
- Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network (2016) (59)
- Titration of Syntaxin1 in Mammalian Synapses Reveals Multiple Roles in Vesicle Docking, Priming, and Release Probability (2013) (59)
- Analysis of SCAMP1 Function in Secretory Vesicle Exocytosis by Means of Gene Targeting in Mice* (1999) (58)
- Calelectrin self‐aggregates and promotes membrane aggregation in the presence of calcium. (1982) (58)
- Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I. (1996) (58)
- Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins. (2000) (58)
- β-Neurexin Is a Ligand for the Staphylococcus aureus MSCRAMM SdrC (2010) (58)
- Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors (2016) (56)
- Pathogenic Mechanism of an Autism-Associated Neuroligin Mutation Involves Altered AMPA-Receptor Trafficking (2015) (56)
- An unusual C2‐domain in the active‐zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release (2001) (56)
- Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. (1993) (55)
- A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory (2018) (55)
- Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction (2016) (55)
- Domain structure of a mammalian myosin I beta. (1994) (55)
- Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins (2013) (55)
- Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development. (1990) (54)
- α-Latrotoxin Stimulates a Novel Pathway of Ca2+-Dependent Synaptic Exocytosis Independent of the Classical Synaptic Fusion Machinery (2009) (53)
- Munc 13 C 2 B domain is an activity-dependent Ca 2 + regulator of synaptic exocytosis (2010) (53)
- Synaptotagmin-7 Is Essential for Ca2+-Triggered Delayed Asynchronous Release But Not for Ca2+-Dependent Vesicle Priming in Retinal Ribbon Synapses (2015) (52)
- Dissection of Synapse Induction by Neuroligins EFFECT OF A NEUROLIGIN MUTATION ASSOCIATED WITH AUTISM* (2005) (52)
- Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells (2003) (52)
- Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways (2019) (52)
- The cDNA and derived amino acid sequences for rat and human synaptophysin. (1987) (51)
- CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. (2006) (50)
- Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. (1990) (49)
- Molecular Neuroscience in the 21st Century: A Personal Perspective (2017) (49)
- C-terminal domain of mammalian complexin-1 localizes to highly curved membranes (2016) (49)
- Newly Synthesized Phosphatidylinositol Phosphates Are Required for Synaptic Norepinephrine but Not Glutamate or γ-Aminobutyric Acid (GABA) Release* (1998) (49)
- Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport* (2004) (48)
- Crystal Structure of the Second LNS/LG Domain from Neurexin 1α (2006) (48)
- Synaptotagmin 13: structure and expression of a novel synaptotagmin. (2001) (47)
- Mechanics of membrane fusion (1998) (47)
- Developmentally Regulated Alternative Splicing in a Novel Synaptojanin* (1998) (45)
- Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation (2016) (45)
- Polypeptide composition of the alpha-latrotoxin receptor. High affinity binding protein consists of a family of related high molecular weight polypeptides complexed to a low molecular weight protein. (1993) (44)
- Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily. (2015) (44)
- Genetic Analysis of α-Latrotoxin Receptors Reveals Functional Interdependence of CIRL/Latrophilin 1 and Neurexin 1α* (2002) (43)
- Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2. (2014) (43)
- Role of calcium in neurotransmitter release evoked by α-latrotoxin or hypertonic sucrose (2000) (43)
- Cerebellins are differentially expressed in selective subsets of neurons throughout the brain (2017) (43)
- Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain (2018) (43)
- NECABs: a family of neuronal Ca2+-binding proteins with an unusual domain structure and a restricted expression pattern (2002) (43)
- ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones (2017) (43)
- Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction (2010) (42)
- Two distinct domains in hsc70 are essential for the interaction with the synaptic vesicle cysteine string protein. (1999) (42)
- Synaptic vesicle proteins in exocytosis: what do we know? (1993) (42)
- Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I. (2002) (41)
- Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held (2017) (41)
- Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons (2018) (41)
- Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. (2004) (41)
- Direct Visualization of Trans-Synaptic Neurexin–Neuroligin Interactions during Synapse Formation (2014) (41)
- IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning (2017) (40)
- Persistent transcriptional programmes are associated with remote memory (2020) (40)
- Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. (2004) (39)
- Neurexins cluster Ca2+ channels within the presynaptic active zone (2020) (39)
- Calelectrin, a Calcium‐Dependent Membrane‐Binding Protein Associated with Secretory Granules in Torpedo Cholinergic Electromotor Nerve Endings and Rat Adrenal Medulla (1983) (38)
- Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk (2019) (38)
- Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses (2019) (38)
- Solution structure of the Vam7p PX domain. (2002) (38)
- RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia (2010) (38)
- α‐latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane (2000) (37)
- Distinct Ca and Sr Binding Properties of Synaptotagmins DEFINITION OF CANDIDATE Ca SENSORS FOR THE FAST AND SLOW COMPONENTS OF NEUROTRANSMITTER RELEASE* (1995) (36)
- RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse. (2015) (36)
- A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release. (2020) (36)
- Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP (2013) (35)
- Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release (2017) (34)
- Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning (2019) (34)
- Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II* (2002) (34)
- Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons (2020) (34)
- Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7 (2010) (34)
- Synaptic targeting domains of synapsin I revealed by transgenic expression in photoreceptor cells. (1994) (34)
- Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk (2018) (33)
- Cysteine string protein‐α is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse (2008) (33)
- Unexpected Ca2+-binding properties of synaptotagmin 9. (2004) (33)
- C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function (2005) (33)
- Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. (2005) (33)
- Characterization of Calelectrin, a Ca2+‐Binding Protein Isolated from the Electric Organ of Torpedo marmorata (1985) (33)
- Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity (2019) (32)
- Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons* (2010) (32)
- α-Latrotoxin Receptor CIRL/Latrophilin 1 (CL1) Defines an Unusual Family of Ubiquitous G-protein-linked Receptors (1998) (32)
- Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. (1998) (32)
- Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis*♦ (2010) (31)
- Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons (2016) (31)
- Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity. (2019) (31)
- LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses (2020) (31)
- A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons (2019) (30)
- Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. (1993) (30)
- Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells (2010) (30)
- The Synaptic Vesicle Cycle in the Nerve Terminal (1999) (30)
- Synaptic function of nicastrin in hippocampal neurons (2014) (30)
- A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference (2020) (29)
- The relation of protein binding to function: what is the significance of munc18 and synaptotagmin binding to syntaxin 1, and where are the corresponding binding sites? (2000) (28)
- RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development (2021) (28)
- The Top Loops of the C2 Domains from Synaptotagmin and Phospholipase A2 Control Functional Specificity* (2001) (27)
- Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles. (1990) (27)
- Latrophilin GPCR signaling mediates synapse formation (2021) (27)
- Core structure, internal osmotic pressure and irreversible structural changes of chromaffin granules during osmometer behaviour. (1982) (27)
- Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification (2006) (27)
- SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins (2020) (26)
- Membrane fusion as a team effort (2007) (26)
- Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism (2020) (26)
- Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes (2020) (26)
- Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca 2+ -Sensor (2011) (26)
- Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses (2018) (25)
- Pharmacology of neurotransmitter release (2008) (24)
- The Neurobiology of Opioid Addiction and the Potential for Prevention Strategies. (2018) (24)
- Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1 (2001) (24)
- Postsynaptic N-methyl-D-aspartate receptor function requires-neurexins (2004) (23)
- Stimulus-dependent dynamic homo- and heteromultimerization of synaptobrevin/VAMP and synaptophysin. (2004) (23)
- Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts (2013) (23)
- Evolutionary conservation of complexins: from choanoflagellates to mice (2015) (23)
- Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex (2018) (22)
- Rat homologues of yeast sec7p. (1997) (22)
- Are neuronal SNARE proteins Ca2+ sensors? (2005) (22)
- Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes. (1990) (22)
- Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts. Coordinate signaling changes and differential suppression of cell growth and transformation. (1994) (21)
- Crystal structure of the RIM2 C2A-domain at 1.4 A resolution. (2005) (21)
- GluD1 is a signal transduction device disguised as an ionotropic receptor (2021) (21)
- Complexins Regulate a Late Step in Ca 2 1-Dependent Neurotransmitter Release cellular (2001) (20)
- Neurexins are functional alpha-latrotoxin receptors. (1999) (20)
- Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum (2020) (20)
- Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca2+ channels (2017) (20)
- Treatment of a genetic brain disease by CNS-wide microglia replacement (2022) (20)
- Reproducibility: Experimental mismatch in neural circuits (2015) (19)
- Calelectrins are a ubiquitous family of Ca2+-binding proteins purified by Ca2+-dependent hydrophobic affinity chromatography by a mechanism distinct from that of calmodulin. (1984) (19)
- Characterization of rabphilin phosphorylation using phospho-specific antibodies (2001) (19)
- Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs (2018) (19)
- Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not Spontaneous Neurotransmitter Release at Neuromuscular Synapses (2019) (19)
- Calcium-promoted resonance energy transfer between fluorescently labeled proteins during aggregation of chromaffin granule membranes. (1982) (19)
- Lipid and protein interactions in ca-promoted aggregation and fusion of chromaffin granule membranes. (1982) (18)
- FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice (2016) (18)
- Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression (2015) (18)
- Ubiquitin–Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice (2015) (18)
- Role of calcium in neurotransmitter release evoked by alpha-latrotoxin or hypertonic sucrose. (2000) (18)
- Crystal Structure of the RIM1α C2B Domain at 1.7 Å Resolution (2007) (18)
- Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion (2010) (18)
- Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism (2020) (17)
- Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron (2012) (17)
- High affinity binding of alpha-latrotoxin to recombinant neurexin I alpha. (1995) (17)
- Synaptic Vesicles: An Organelle Comes of Age (2006) (17)
- Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules (2021) (17)
- Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents (2020) (16)
- The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones (2014) (16)
- Molecular approaches to synaptic vesicle exocytosis. (1993) (16)
- Calelectrin in human blood cells. (1983) (16)
- Molecular Analysis of Inositol 1,4,5-Trisphosphate Receptors (1993) (15)
- High-level expression of the 32.5-kilodalton calelectrin in ductal epithelia as revealed by immunocytochemistry. (1986) (15)
- Truth in Science Publishing: A Personal Perspective (2016) (15)
- Implications for Intracellular Trafficking (1999) (14)
- lnsP3 receptor turnaround (1990) (13)
- Astrocytic Neurexin-1 Orchestrates Functional Synapse Assembly (2020) (13)
- Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics (2021) (13)
- Neurexins regulate presynaptic GABAB-receptors at central synapses (2021) (13)
- Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing (2019) (13)
- Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes (2011) (12)
- Mammary gland Ca2+‐binding (‐dependent) proteins: Identification as calelectrins and calpactin I/p36 (1988) (12)
- Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation (2016) (12)
- The chromaffin granule as a model for membrane fusion: implications for exocytosis. (1983) (12)
- Evolutionary conservation and structural determinants of the calelectrins (annexins). (1990) (12)
- Erratum: Synaptotagmins: C2-domain proteins that regulate membrane traffic (Neuron (1996) 17 (379-388)) (1996) (11)
- Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly (2020) (11)
- The Molecular Machinery of Neurotransmitter Release (2014) (11)
- Synaptogenic effect of APP-Swedish mutation in familial Alzheimer’s disease (2022) (11)
- The conditional KO approach: Cre/Lox technology in human neurons (2016) (11)
- Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus (2017) (10)
- Characteristics and determinants of osmotic lysis in chromaffin granules. (1983) (10)
- Assignment of the 1H, 15N and13 C resonances of the calcium-free and calcium-bound forms of the first C2-domain of synaptotagmin I (1997) (10)
- RIM‐binding proteins recruit BK‐channels to presynaptic release sites adjacent to voltage‐gated Ca2+‐channels (2018) (10)
- Region-specific deletions of RIM1 reproduce a subset of global RIM1α−/− phenotypes (2012) (10)
- A simple Ca2+-imaging approach to neural network analyses in cultured neurons (2020) (10)
- Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. (2020) (10)
- Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F. (1995) (9)
- Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses (2021) (9)
- Testing the SNARE/SM protein model of membrane fusion (2010) (9)
- The calelectrins: new and ubiquitous Ca2+-regulated proteins with a possible role in cytotic processes. (1984) (9)
- Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules (2006) (9)
- Identification, expression, and crystallization of the protease‐resistant conserved domain of synapsin I (1997) (8)
- Crystal Structure of the RIM 1 R C 2 B Domain at 1 . 7 Å Resolution (8)
- Cerebellin-2 Regulates a Serotonergic Dorsal Raphe Circuit that Controls Compulsive Behaviors (2021) (8)
- THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN (1999) (7)
- Conditional knockout of Nlgn2 in the adult medial prefrontal cortex (mPFC) induces delayed loss of inhibitory synapses (2015) (7)
- Endocytosis in the axon initial segment maintains neuronal polarity (2022) (7)
- Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. (2007) (7)
- Evidence for a divalent cation dependent catecholamine storage complex in chromaffin granules. (1983) (7)
- Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice (2022) (6)
- The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins (2021) (6)
- An interview with Randy Schekman and Thomas Südhof. (2014) (6)
- Neurexophilin Binding to α-Neurexins (1998) (6)
- [3] Purification of calelectrins (1987) (6)
- Building bridges between neuroscientific evidence and policy (2015) (6)
- Ultrastructure of Synapses in the Mammalian (2012) (6)
- Composition of Synaptic Vesicles (1999) (6)
- Discrete and Continuous Cell Identities of the Adult Murine Striatum (2019) (6)
- Rapid generation of functional and homogeneous excitatory human forebrain neurons using Neurogenin-2 (Ngn2) (2018) (5)
- Synaptic vesicles. (1989) (5)
- Molecular self-avoidance in synaptic neurexin complexes (2021) (5)
- CAPS in search of a lost function. (2005) (5)
- Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands (2022) (5)
- InsP3 receptor turnaround. (1990) (5)
- Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia (2020) (5)
- Neurexin IlIa: Extensive alternative splicing generates membrane-bound and soluble forms (2005) (5)
- Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses (2022) (4)
- Author response: Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 (2013) (4)
- RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development (2022) (4)
- Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury (2015) (4)
- Analyses of the Autism-associated Neuroligin-3 R451C Mutation in Human Neurons Reveals a Gain-of-Function Synaptic Mechanism (2021) (4)
- Functional architecture of the synaptic transducers at a central glutamatergic synapse (2020) (4)
- P1-284 Cleavage of APP and APLP's by BACE 1 (2004) (4)
- Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki) (2011) (4)
- Scientific Background Machinery Regulating Vesicle Traffic, A Major Transport System in our Cells (2013) (4)
- Building Bridges through Science (2017) (3)
- Synaptotagmin 1 C 2 B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions (2003) (3)
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly (2021) (3)
- GENERATION OF TRANSGENIC MICE FOR IN VIVO DETECTION OF INSULIN-CONTAINING GRANULE EXOCYTOSIS AND QUANTIFICATION OF INSULIN SECRETION (2009) (3)
- Synaptogenesis: When Long-Distance Relations Become Intimate (2006) (3)
- Insulin Release : Some Molecular Requisites Molecular Determinants of Regulated Exocytosis (2002) (3)
- Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus (2023) (3)
- Nanometer-Resolution Long-term Tracking of Single Cargos Reveals Dynein Motor Mechanisms (2022) (3)
- A systematic approach to studying synaptic function in vertebrates. (1995) (2)
- Temperature-induced lysis of chromaffin granules provides evidence against the two-pool hypothesis of catecholamine storage. (1983) (2)
- THE DYNAMIC INTERPLAY BETWEEN HOMEODOMAIN TRANSCRIPTION FACTORS AND CHROMATIN ENVIRONMENT REGULATES PRONEURAL FACTOR OUTCOMES (2020) (2)
- ApoE2, ApoE3 and ApoE4 Differentially Impact Multiple Signaling Pathways Regulating Synaptogenesis (2018) (2)
- Crystal Structure of the RIM2 C2A-domain at 1.4 angstrom Resolution (2005) (2)
- A toolbox of nanobodies developed and validated for diverse neuroscience research applications (2019) (2)
- Piconewton forces mediate GAIN domain dissociation of the latrophilin-3 adhesion GPCR (2023) (2)
- Postsynaptic synucleins mediate vesicular exocytosis of endocannabinoids (2021) (2)
- Dissociating encoding of memory and salience by manipulating long-term synaptic potentiation (2022) (2)
- A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop (2022) (2)
- The synapse : a subject collection from Cold Spring Harbor perspectives in biology (2012) (2)
- Transsynaptic cerebellin 4–neogenin 1 signaling mediates LTP in the mouse dentate gyrus (2022) (2)
- Induction of synapse formation by de novo neurotransmitter synthesis (2022) (2)
- Metal Binding Motifs in Cholinesterases and Neuroligins (1998) (2)
- A simple Ca2+-imaging approach to neural network analysis in cultured neurons (2020) (2)
- RIBEYE B-Domain Is Essential for RIBEYE A-Domain Stability and Assembly of Synaptic Ribbons (2022) (2)
- C2-Domains in Ca2+-Signaling (2003) (2)
- Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum (2022) (1)
- Rim1 and Rim2 Redundantly Determine Ca 2+ Channel Density and Readily-releasable Pool 2 Size at a Large Hindbrain Synapse 3 4 5 (2014) (1)
- La machinerie moléculaire de sécrétion des neurotransmetteurs (2015) (1)
- The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1 (2021) (1)
- New neurexin iso-Seq paper in Neuron WEDNESDAY, MARCH 19, 2014 Assessment of Highly Complex Alternative Splicing of Neurexins Performed with SMRT Sequencing (2014) (1)
- An interview with the Kavli prize winners. Interview by Claudia Wiedemann. (2010) (1)
- Author response: LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses (2020) (1)
- Synaptic Vesicle Membrane Traffic and the Cycle of Rab3 (1993) (1)
- Persistent transcriptional programs are associated with remote memory in diverse cells of the medial prefrontal cortex (2019) (1)
- Crystal Structure of the second LNS/LG domain from Neurexin 1 alpha (2006) (1)
- Instructions for the preparation of gene mapping reports (1995) (1)
- α-Synuclein, CSPα, SNAREs and Neuroprotection in vivo (2008) (1)
- Structure of the teneurin-latrophilin complex: Alternative splicing controls synapse specificity by a novel mechanism (2020) (1)
- [The molecular machinery of neurotransmitter secretion]. (2015) (1)
- Characteristics of Synaptic Vesicle Exocytosis (1999) (1)
- Structural and Functional Studies of Latrophilin‐Family Adhesion G‐Protein Coupled Receptors (2017) (1)
- Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner (2022) (1)
- Manu Sharma Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration (2012) (1)
- Structural Basis of Latrop hilin-FLRT-UNC 5 Interaction in Cell Adhesion Graphical (2015) (1)
- b-Neurexin Is a Ligand for the Staphylococcus aureus MSCRAMM (2009) (1)
- Explorer Presenilins are essential for regulating neurotransmitter release (2016) (0)
- Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory (2023) (0)
- Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism (2023) (0)
- Structural basis for the evolutionary inactivation of Ca[superscript 2+] binding to synaptotagmin 4 (2010) (0)
- Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes (2020) (0)
- JCB_20160608603092017C 1..1 (2017) (0)
- Synaptic vescicles and exocytosis (1994) (0)
- Proteolytic regulation of calcium channels - avoiding controversy. (2022) (0)
- Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex (2007) (0)
- As of today, 30 Nobel Laureates have endorsed the attached January 19, 2016, H.R. Network's Statement to the Government of Turkey regarding the plight of hundreds of Turkish academic colleagues. (2016) (0)
- CORRECTIONS (2007) (0)
- Vivo In Peptides in the CA1 Region of the Rat Hippocampus -Amyloid β Blockade of Long-Term Potentiation by (2015) (0)
- 1 Dynamic Synaptotagmin-1-SNARE Complex Binding Mode in Solution (2015) (0)
- The Autism Risk Factor CHD8 Is a Chromatin Activator and Functionally Dependent on the ERK-MAPK Pathway Effector ELK1 (2020) (0)
- The Molecular Logic Organizing the Functional Compartmentalization of Reciprocal Synapses (2021) (0)
- Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture (2023) (0)
- Supplemental Data Nicastrin Functions as a γ-Secretase-Substrate Receptor (2005) (0)
- VAM3P N-TERMINAL DOMAIN SOLUTION STRUCTURE (2001) (0)
- Receptor Responses in a Circuit-Dependent Manner (0)
- Molecular Mechanisms Controlling Neurotransmitter Release by the Primed SNARE-complexin-Synaptotagmin Complex (2018) (0)
- CB1 receptor activation rapidly alters synaptic vesicle numbers in mouse hippocampal synapses (2021) (0)
- Neurexins and Company: towards a molecular logic of neural circuits (2015) (0)
- Towards Understanding the Molecular Mechanism of Synchronous Neurotransmitter Release (2017) (0)
- Novel Neuron Types and Anatomical Organization of the Striatum Revealed by Single-Cell RNA-Seq. (2016) (0)
- Purification of calelectrins. (1987) (0)
- P1-183 Three-dimensional structure of an autonomously folded domain of human amyloid-β precursor protein (2004) (0)
- P-557: Synapsin as a potential new drug target for hypertension (2001) (0)
- QnAs with Thomas C. Südhof. Interview by Prashant Nair. (2010) (0)
- A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory (2018) (0)
- Interaction of recombinant soluble neuroligin-1 with neurexin-1-_ (2004) (0)
- Human Teneurin 2 extra-cellular region (2018) (0)
- Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones (2017) (0)
- Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism (2020) (0)
- A role for Rab3a in the final stages of synaptic vesicle exocytosis. (1996) (0)
- Why publish single observations? Because Science Matters. (2016) (0)
- Calelectrin, an Mr-32000 polypeptide, is associated with membranes and cytoskeleton in a calcium-dependent manner (1983) (0)
- Study on vitamin D supplementation seeks participants who are at risk for diabetes ten scholars receive Spectrum clinical research training awards (2013) (0)
- Elements regulateurs de sterol (1988) (0)
- A conversation with Thomas Südhof. Interview by Ushma S. Neill. (2013) (0)
- Machinerie moléculaire de la libération des neurotransmetteurs (2014) (0)
- Mechanism of Ca 2 +-Regulated Membrane Fusion (2011) (0)
- Postsynaptic Synucleins Mediate the Release of Endocannabinoids (2022) (0)
- Intracellular Membrane Traffic (1999) (0)
- Three-dimensional structure of the calcium-free Piccolo C2A-domain (2004) (0)
- Crystal structure of the C domain of synapsin Ia from bovine (1996) (0)
- Munc 18-1 is essential for synaptic secretion by making synaptic vesicles fusion-ready (2001) (0)
- Persistent transcriptional programmes are associated with remote memory (2020) (0)
- Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury (2015) (0)
- Calsyntenin-3, an atypical cadherin, suppresses inhibitory basket- and stellate-cell synapses but boosts excitatory parallel-fiber synapses in cerebellum (2021) (0)
- Engineered adhesion molecules drive synapse organization (2022) (0)
- Calmodulin Suppresses Synaptotagmin-2 Transcription in (2010) (0)
- Faculty Opinions recommendation of Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. (2002) (0)
- Cell Stem Cell Generation of iN Cells from Liver 2 Cell (2011) (0)
- Structures of C 1 q-like Pro teins Reveal Unique Features among the C 1 q / TNF Superfamily Graphical Abstract Highlights (2015) (0)
- Decision letter: Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus (2020) (0)
- rat synaptotagmin 4 C2B domain in the presence of calcium (2004) (0)
- Backbone Assignments of folded alpha-synuclein (2003) (0)
- RIM1andRIM1AreSynthesizedfromDistinctPromoters oftheRIM1GenetoMediateDifferentialButOverlapping SynapticFunctions (2008) (0)
- Crystal structure of the GAIN and HormR domains of CIRL 1/Latrophilin 1 (CL1) (2012) (0)
- Single piconewton forces regulate dissociation of the Latrophilin-3 gain domain. (2023) (0)
- SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I (1998) (0)
- Pathomechanismen der auditorischen Neuropathie (2005) (0)
- Cloning, Characterization, andExpression ofaNovelGDP Dissociation Inhibitor Isoform fromSkeletal Muscle (1994) (0)
- Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein (2004) (0)
- THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A (1998) (0)
- Role of Neurexins and Neuroligins in synapse development and maintenance (2016) (0)
- The RIM1alpha C2B domain (2007) (0)
- 134th Annual Meeting Works in Progress Abstracts (2009) (0)
- Modeling for neurological diseases using human ES cell-derived neurons (2008) (0)
- Characteristics and Proteins of Synaptic Vesicle Endocytosis (1999) (0)
- Crystal structure of the extracellular esterase domain of Neuroligin-1 (2007) (0)
- Postsynaptic complexin controls AMPA receptor exocytosis during long term potentiation (2012) (0)
- S1-01-04 APP intracellular domain (2004) (0)
- Author response: Latrophilin GPCR signaling mediates synapse formation (2021) (0)
- Not All Embryonic Stem Cell Lines Are Created Equal (2007) (0)
- Proteins that Function in Synaptic Vesicle Exocytosis (1999) (0)
- Table of Contents (1991) (0)
- Activity-dependent synapse validation by neurexin ligands, LRRTMs and neuroligins (2011) (0)
- Analysis of neuroligin-3 knock-in mice relevant to autism spectrum disorders (2009) (0)
- Author response: Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum (2020) (0)
- Thomas C. Südhof, MD, The University of Texas Southwestern Medical Center at Dallas, Wins Bristol-Myers Squibb Neuroscience Research Award (2004) (0)
- By sterols regulated promoter elements. (1988) (0)
- Solution structure of Rim2 Zinc Finger Domain (2005) (0)
- Crystal structure of the GAIN and HormR domains of brain angiogenesis inhibitor 3 (BAI3) (2012) (0)
- Direct induction of human neurons from fibroblasts carrying the neuropsychiatric 22q11.2 microdeletion reveals transcriptome- and epigenome-wide alterations (2021) (0)
- Identification of Endogenous/transfected Synaptic Proteins in Primary Neuronal Culture by a High-yield Immunogold Labeling (2003) (0)
- Dynamin: Potential regulator of vesicle dynamics (1994) (0)
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Other Resources About Thomas C. Südhof
What Schools Are Affiliated With Thomas C. Südhof?
Thomas C. Südhof is affiliated with the following schools:
- Stanford University
- Rockefeller University
- Baylor College of Medicine
- RWTH Aachen University
- University of California, San Francisco
- Columbia University
- Thomas Jefferson University
- University of Texas Southwestern Medical Center
- Harvard University
- Consorzio ICoN
- Yale University
- Vrije Universiteit Amsterdam
- University of Göttingen
