Thomas Scammell
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Thomas Scammell's Degrees
- Doctorate Medicine Harvard University
Why Is Thomas Scammell Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thomas E. Scammell is an American neurologist, known for his research in sleep medicine pertaining to neurobiology of sleep and sleep disorders, particularly narcolepsy and cataplexy. Scammell is a professor of neurology at Harvard Medical School, serving the department of neurology at Beth Israel Deaconess Medical Center and Boston Children's Hospital.
Thomas Scammell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation (1999) (2897)
- Hypothalamic regulation of sleep and circadian rhythms (2005) (2373)
- The sleep switch: hypothalamic control of sleep and wakefulness (2001) (1525)
- Sleep State Switching (2010) (1061)
- Fos Expression in Orexin Neurons Varies with Behavioral State (2001) (657)
- Afferents to the orexin neurons of the rat brain (2006) (559)
- Melanopsin in cells of origin of the retinohypothalamic tract (2001) (551)
- Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling (2001) (533)
- Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms (2003) (507)
- Neural Circuitry of Wakefulness and Sleep (2017) (504)
- Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness (2000) (465)
- Afferents to the Ventrolateral Preoptic Nucleus (2002) (445)
- Orexin (Hypocretin) Neurons Contain Dynorphin (2001) (400)
- Behavioral State Instability in Orexin Knock-Out Mice (2004) (368)
- Homeostatic, circadian, and emotional regulation of sleep (2005) (363)
- Distribution of fos‐like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration (1996) (343)
- Orexin receptors: pharmacology and therapeutic opportunities. (2011) (305)
- Intravenous lipopolysaccharide induces cyclooxygenase 2‐like immunoreactivity in rat brain perivascular microglia and meningeal macrophages (1997) (292)
- Concomitant loss of dynorphin, NARP, and orexin in narcolepsy (2005) (285)
- Ventromedial Preoptic Prostaglandin E2 Activates Fever-Producing Autonomic Pathways (1996) (252)
- Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment (2019) (239)
- The neurobiology, diagnosis, and treatment of narcolepsy (2003) (238)
- Sleep neurobiology from a clinical perspective. (2011) (236)
- An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons (2001) (236)
- Common scale-invariant patterns of sleep-wake transitions across mammalian species. (2004) (234)
- Sleep modulates hematopoiesis and protects against atherosclerosis (2018) (218)
- Neural circuitry engaged by prostaglandins during the sickness syndrome (2012) (208)
- Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. (2005) (198)
- Loss of hypocretin (orexin) neurons with traumatic brain injury (2009) (164)
- Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. (1998) (160)
- A consensus definition of cataplexy in mouse models of narcolepsy. (2009) (151)
- Relationship of EP1‐4 prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses (2000) (148)
- Sleep neurobiology for the clinician. (2004) (146)
- Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice (2018) (140)
- Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. (2014) (139)
- Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice (2017) (134)
- Dynamic GABAergic afferent modulation of AgRP neurons (2016) (129)
- Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice (2011) (127)
- Increase of histaminergic tuberomammillary neurons in narcolepsy (2013) (126)
- Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons (2003) (125)
- Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke (2001) (123)
- The neurobiological basis of narcolepsy (2018) (114)
- Narcolepsy: Neural Mechanisms of Sleepiness and Cataplexy (2012) (113)
- Mathematical model of network dynamics governing mouse sleep-wake behavior. (2007) (112)
- Hcrtr1 and 2 signaling differentially regulates depression-like behaviors (2011) (110)
- Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever. (1996) (109)
- Wake-related activity of tuberomammillary neurons in rats (2003) (104)
- Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling. (2003) (103)
- Abnormal sleep/wake dynamics in orexin knockout mice. (2010) (103)
- Running promotes wakefulness and increases cataplexy in orexin knockout mice. (2007) (102)
- Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. (1998) (100)
- Control of arousal by the orexin neurons (2013) (99)
- Decreased alertness due to sleep loss increases pain sensitivity in mice (2017) (95)
- Silent functional magnetic resonance imaging demonstrates focal activation in rapid eye movement sleep (1999) (95)
- Focal Deletion of the Adenosine A1 Receptor in Adult Mice Using an Adeno-Associated Viral Vector (2003) (94)
- Hyperthermia induces c-fos expression in the preoptic area (1993) (91)
- Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates (2005) (91)
- Orexin neurons are necessary for the circadian control of REM sleep. (2009) (88)
- Listening to the Patient Voice in Narcolepsy: Diagnostic Delay, Disease Burden, and Treatment Efficacy. (2017) (86)
- Activation of the basal forebrain by the orexin/hypocretin neurones (2010) (84)
- Amygdala Lesions Reduce Cataplexy in Orexin Knock-Out Mice (2013) (83)
- Optogenetic-Mediated Release of Histamine Reveals Distal and Autoregulatory Mechanisms for Controlling Arousal (2014) (82)
- Elevated body temperature during sleep in orexin knockout mice. (2006) (81)
- Role of the Medial Prefrontal Cortex in Cataplexy (2013) (80)
- Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. (2008) (74)
- Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. (2013) (68)
- Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. (2016) (64)
- Polymorphisms in hypocretin/orexin pathway genes and narcolepsy (2001) (64)
- Feeding-elicited cataplexy in orexin knockout mice (2009) (63)
- Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy (2002) (62)
- Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury (2015) (62)
- Modafinil: a drug in search of a mechanism. (2004) (61)
- Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons (2003) (61)
- Diurnal variation in CSF orexin-A in healthy male subjects. (2006) (56)
- Pharmacotherapy for cataplexy. (2004) (54)
- Histamine: neural circuits and new medications (2018) (53)
- The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy. (2006) (51)
- Reward-seeking behavior in human narcolepsy. (2011) (50)
- Effects of vagus nerve stimulation on respiration during sleep (2001) (48)
- GABAergic Neurons of the Central Amygdala Promote Cataplexy (2017) (48)
- Orexin, drugs and motivated behaviors (2005) (48)
- Complementary roles of gasotransmitters CO and H2S in sleep apnea (2017) (47)
- Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia (2005) (44)
- Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice. (2013) (44)
- Basal forebrain subcortical projections (2019) (44)
- Cataplexy and Its Mimics: Clinical Recognition and Management (2017) (41)
- Coexistence of narcolepsy and Alzheimer's disease (2012) (38)
- Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness. (2016) (38)
- SCOPRISM: A new algorithm for automatic sleep scoring in mice (2014) (38)
- Narcolepsy caused by acute disseminated encephalomyelitis. (2004) (37)
- The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy? (2010) (37)
- Orexins: looking forward to sleep, back at addiction (2007) (34)
- Cerebral deep venous thrombosis presenting as acute micrographia and hypophonia (2000) (33)
- Parkinson's disease, sleepiness and hypocretin/orexin. (2008) (32)
- Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord (2014) (32)
- Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1β: Investigating a Method for the Study of Fatigue in Laboratory Animals (2015) (31)
- Delusional confusion of dreaming and reality in narcolepsy. (2014) (31)
- Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. (2015) (31)
- Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury. (2016) (29)
- Usefulness of a Nocturnal SOREMP for Diagnosing Narcolepsy with Cataplexy in a Pediatric Population. (2015) (29)
- Do enteric neurons make hypocretin? (2008) (29)
- Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. (1998) (29)
- Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy (2018) (28)
- Late breaking abstracts (2007) (28)
- Sodium oxybate is an effective and safe treatment for narcolepsy. (2010) (28)
- Descending projections from the basal forebrain to the orexin neurons in mice (2017) (26)
- Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control (2019) (25)
- Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake (2019) (24)
- The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep (2015) (24)
- Modafinil: a novel stimulant for the treatment of narcolepsy. (1998) (23)
- Insight Into Reduction of Wakefulness by Suvorexant in Patients With Insomnia: Analysis of Wake Bouts (2018) (23)
- Orexin/Hypocretin: Wired for Wakefulness (2003) (23)
- Regulation of hippocampal dendritic spines following sleep deprivation (2020) (22)
- Behavioral state instability in orexin knockout mice (2004) (22)
- A circuit perspective on narcolepsy (2020) (21)
- Wakefulness: An eye-opening perspective on orexin neurons (2001) (20)
- Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("Limp Man Syndrome") (2004) (19)
- Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice. (2019) (19)
- Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia? (2009) (18)
- Dysregulation of Sleep Behavioral States in Narcolepsy (2017) (17)
- Dynorphin inhibits basal forebrain cholinergic neurons by pre‐ and postsynaptic mechanisms (2016) (17)
- Children with Narcolepsy type 1 have increased T‐cell responses to orexins (2019) (17)
- Overview of sleep: the neurologic processes of the sleep-wake cycle. (2015) (16)
- Emerging therapeutics in sleep (2013) (15)
- Bradysomnia in Parkinson’s disease (2016) (15)
- Severe acute disseminated encephalomyelitis with normal MRI at presentation (2000) (14)
- Inter-Hemispheric Oscillations in Human Sleep (2012) (14)
- Defining Disrupted Nighttime Sleep and Assessing its Diagnostic Utility for Pediatric Narcolepsy Type 1. (2020) (13)
- Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity (2021) (10)
- No evidence for a circadian rhythm of protein synthesis in the rat suprachiasmatic nuclei (1989) (8)
- Stability of Nocturnal Wake and Sleep Stages Defines CNS Disorders of Hypersomnolence. (2021) (8)
- Orexin neurons inhibit sleep to promote arousal (2022) (8)
- The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy (2021) (7)
- COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence. (2020) (7)
- Sleep modulates haematopoiesis and protects against atherosclerosis (2019) (6)
- REM Sleep Behavior Disorder in Narcolepsy (2006) (5)
- Input–output connections of LJA5 prodynorphin neurons (2020) (5)
- Treatment of narcolepsy with natalizumab. (2020) (4)
- Clinical considerations for the diagnosis of idiopathic hypersomnia. (2022) (4)
- Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a (2022) (3)
- Development and Validation of the Pediatric Hypersomnolence Survey (2022) (3)
- , Hypothalamic EGF Receptor Signaling Regulation of Daily Locomotor Activity and Sleep (2008) (3)
- 0134 OXYTOCIN FIBERS IN THE LATERAL HYPOTHALAMUS PROMOTE AROUSAL IN A MOUSE MODEL OF PWS (2017) (3)
- Orexin and Hypothalamic Control of Sleep and Waking (2006) (2)
- Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area. (2016) (2)
- Corrigendum: Orexin, drugs and motivated behaviors (2005) (2)
- Modafinil containing composition for the treatment of attention deficit / hyperactivity (2000) (1)
- Major advances in sleep neurology: 2002–22 (2022) (1)
- Author response for "Input‐output connections of LJA5 prodynorphin neurons" (2020) (1)
- The impact of narcolepsy on social relationships in young adults. (2022) (1)
- The role of adenosine A1 receptors in sleep and behavioral arousal; focal gene deletion using the Cre-loxP system (2002) (1)
- Critical dynamics in bursts of δ and θ-rhythms across the sleep-wake cycle (2019) (0)
- Designing a Multi-locomotion Modular Snake Robot (2021) (0)
- 498 It Makes Relationships Harder: The Role of Narcolepsy in Social and Romantic Relationships in Young Adults (2021) (0)
- Defining disrupted nighttime sleep (DNS) in pediatric narcolepsy (2019) (0)
- AntagonismMotor Nucleus Are Reversed by NMDA Excitatory Effects of Hypocretin-1 (Orexin-A) in the (2015) (0)
- Sleep stabilization patterns define pediatric CNS hypersomnia conditions (2019) (0)
- 0005 Cataplexy Triggered by Social Cues: A Role for Oxytocin in the Amygdala (2020) (0)
- 0941 Defining Disrupted Nighttime Sleep in Pediatric Narcolepsy (2020) (0)
- and Sleep: Physiology and Modeling Delayed Orexin Signaling Consolidates Wakefulness (2015) (0)
- Genetic identity of warm and cool thermosensory relay neurons in the mouse parabrachial nucleus (2015) (0)
- 0156 Activation of Glutamatergic PPT Neurons and Their Projections Promotes Arousal, and Distinct Wake Behaviors (2020) (0)
- Catching Up on REMs. (2022) (0)
- 0951 Sleep Stabilization Patterns Define Pediatric CNS Hypersomnia Conditions (2020) (0)
- Narcolepsy and Other Neurological Sleep Disorders (2006) (0)
- Distinct Innervation Patterns of the Melanin Concentrating Hormone Neurons from the Basal Forebrain Structures (I3-2.001) (2014) (0)
- The neurobiological basis of narcolepsy (2018) (0)
- The Neurobiology of Sleep (2007) (0)
- OREXIN GENE TRANSFER RESTORES WAKEFULNESS IN NARCOLEPTIC MICE (2013) (0)
- 001 Exploring the Orexin-tTA/TetO-DTA Mouse as a Model for Pediatric Narcolepsy (2021) (0)
- The somnogen PGD2 induces FOS expression within unique populations of sleep-active neurons (1998) (0)
- 0784 Defining Disrupted Nighttime Sleep in Pediatric Narcolepsy (2018) (0)
- THE NEUROBIOLOGY OF SLEEPINESS IS STILL VERY MUCH A MYSTERY. NARCOLEPSY WITH CATAPLEXY IS CAUSED BY A LOSS OF THE NEURONS PRODUCING the hypocretin/orexin neuropeptides, but for other disorders (2009) (0)
- REDUCED CENTROPARIETAL SLOW WAVE ACTIVITY DURING NON-RAPID EYE MOVEMENT SLEEP IN HYPERSOMNOLENCE DISORDER: A TRANSDIAGNOSTIC (2017) (0)
- The Serotoninergic System in Sleep and Narcolepsy (2011) (0)
- Governing Mouse Sleep Mathematical Model of Network Dynamics (2015) (0)
- Altered circadian rhythms and sleep in a new Angelman Syndrome mouse model (2021) (0)
- Hypocretin Deficiency and HLA in Narcolepsy (2003) (0)
- Seasonal Factors and the Onset of Narcolepsy (2011) (0)
- Basal forebrain subcortical projections (2019) (0)
- The Neural Basis of Sleepiness in Narcoleptic Mice (2011) (0)
- Channel Contribution to Excitability Biophysical Characterization of Rat Caudal Hypothalamic Neurons: Calcium (2008) (0)
- Compositions a base de modafinil destinees au traitement du trouble deficitaire de l'attention avec hyperactivite et de la fatigue associee a la sclerose en plaques (2000) (0)
- 0620 Effect Of Antidepressants On Sleep Architecture (2019) (0)
- M-N-128 THE AMYGDALA IS NECESSARY FOR TRIGGERING CATAPLEXY IN OREXIN KO MICE (2011) (0)
- Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice (2018) (0)
- Glutamatergic PPT neurons control wakefulness and locomotion via distinct axonal projections. (2022) (0)
- Severe cataplexy in a mouse model of childhood narcolepsy (2019) (0)
- Compositions comprenant du modafinil pour le traitement de l'hyperactivite avec deficit de l'attention (2000) (0)
- Development and Validation of the Pediatric Hypersomnia Survey (PHS) (2022) (0)
- Effects of daridorexant and zolpidem on night wakefulness in adults with insomnia: exploratory analysis from a randomized, double-blind, placebo-controlled phase 2 trial (2022) (0)
- Orexin/Hypocretin: Wired for Wakefulness Dispatch (2003) (0)
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