Thomas Eschenhagen
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Thomas Eschenhagen's Degrees
- PhD Biology University of Hamburg
- Doctorate Medicine University of Hamburg
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(Suggest an Edit or Addition)Thomas Eschenhagen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts (2006) (943)
- Tissue Engineering of a Differentiated Cardiac Muscle Construct (2002) (897)
- What Is the Role of &bgr;-Adrenergic Signaling in Heart Failure? (2003) (742)
- Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. (1994) (632)
- Three‐dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system (1997) (591)
- Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. (2000) (457)
- Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. (1999) (419)
- Development of a Drug Screening Platform Based on Engineered Heart Tissue (2010) (408)
- Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology (2011) (380)
- Cardiac tissue engineering: state of the art. (2014) (362)
- Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement (2000) (355)
- Cardiomyocyte Regeneration: A Consensus Statement. (2017) (354)
- Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology (2011) (326)
- MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling (2010) (315)
- Optimizing Engineered Heart Tissue for Therapeutic Applications as Surrogate Heart Muscle (2006) (303)
- Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation. (2014) (281)
- Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation (2010) (271)
- Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation (2006) (268)
- Increased expression of cardiac phosphatases in patients with end-stage heart failure. (1997) (261)
- Cardiac Grafting of Engineered Heart Tissue in Syngenic Rats (2002) (260)
- Human Engineered Heart Tissue: Analysis of Contractile Force (2016) (254)
- Engineering Myocardial Tissue (2005) (254)
- Engineered heart tissue for regeneration of diseased hearts. (2004) (252)
- Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure. (1992) (217)
- Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell–Based Myocardial Salvage After Acute Myocardial Infarction (2009) (203)
- Focal modification of electrical conduction in the heart by viral gene transfer (2000) (203)
- Capturing adenylyl cyclases as potential drug targets (2009) (200)
- CYP2D6 Genotype: Impact on Adverse Effects and Nonresponse During Treatment with Antidepressants—a Pilot Study (2004) (200)
- Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells (2016) (199)
- Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. (2016) (195)
- Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol‐associated adverse effects (2002) (188)
- Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering (2018) (187)
- Cardiac Tissue Engineering for Replacement Therapy (2003) (187)
- Heme oxygenase‐1 and its reaction product, carbon monoxide, prevent inflammation‐related apoptotic liver damage in mice (2003) (185)
- β-Adrenergic stimulation and myocardial function in the failing heart (2009) (184)
- Differentiation of cardiomyocytes and generation of human engineered heart tissue (2017) (174)
- Heart muscle engineering: an update on cardiac muscle replacement therapy. (2006) (174)
- Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants. (2005) (171)
- Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts. (1996) (171)
- High‐dose methotrexate in pediatric acute lymphoblastic leukemia: Impact of ABCC2 polymorphisms on plasma concentrations (2006) (167)
- Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial (2011) (166)
- Engineering Cardiac Muscle Tissue: A Maturating Field of Research. (2017) (164)
- Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. (2007) (158)
- S100A1: A regulator of myocardial contractility (2001) (152)
- Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart. (1995) (151)
- Human engineered heart tissue as a model system for drug testing. (2016) (147)
- SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes (2020) (146)
- Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue (2011) (142)
- Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure (2013) (140)
- CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy (2018) (140)
- Increased afterload induces pathological cardiac hypertrophy: a new in vitro model (2012) (140)
- Bovine dilated cardiomyopathy: Proteomic analysis of an animal model of human dilated cardiomyopathy (1999) (139)
- Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment. (2002) (138)
- In vitro engineering of heart muscle: artificial myocardial tissue. (2002) (136)
- Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts. (2004) (136)
- Cardiac Myosin-Binding Protein C Is Required for Complete Relaxation in Intact Myocytes (2007) (133)
- Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes (2020) (132)
- MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo (2017) (131)
- Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes (2018) (128)
- Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure. (2002) (124)
- Evidence for protein phosphatase inhibitor‐1 playing an amplifier role in β‐adrenergic signaling in cardiac myocytes (2003) (123)
- Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase (1999) (121)
- Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density (2017) (121)
- Impact of the CYP2D6 Genotype on the Clinical Effects of Metoprolol: A Prospective Longitudinal Study (2009) (119)
- Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice (2009) (118)
- Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. (2013) (116)
- Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice (2014) (115)
- Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. (1994) (114)
- Myocardial tissue engineering: in vitro models. (2014) (113)
- Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice (2012) (110)
- Thyroid Hormone Regulates Developmental Titin Isoform Transitions via the Phosphatidylinositol-3-Kinase/ AKT Pathway (2008) (110)
- Parthenogenetic stem cells for tissue-engineered heart repair. (2013) (109)
- Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization (2015) (105)
- Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. (2008) (105)
- Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy. (2012) (101)
- Augmented Expression of Cardiotrophin-1 in Failing Human Hearts Is Accompanied by Diminished Glycoprotein 130 Receptor Protein Abundance (2002) (100)
- Specific β2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the β2AR in Myocytes From Failing Human Heart (2002) (98)
- 3D engineered heart tissue for replacement therapy (2002) (96)
- Physiological aspects of cardiac tissue engineering. (2012) (93)
- Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure. (1998) (93)
- Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. (2010) (91)
- Treatments targeting inotropy. (2018) (91)
- Localization of Islet-1–Positive Cells in the Healthy and Infarcted Adult Murine Heart (2012) (91)
- Development of a Biological Ventricular Assist Device: Preliminary Data From a Small Animal Model (2007) (90)
- Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. (2010) (89)
- Complex Interactions between Human Myoblasts and the Surrounding 3D Fibrin-Based Matrix (2012) (89)
- Effects of metoprolol on myocardial β-adrenoceptors and Giα-proteins in patients with congestive heart failure (1996) (88)
- Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium (2018) (86)
- Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. (2002) (85)
- Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties. (2004) (84)
- Automated analysis of contractile force and Ca2+ transients in engineered heart tissue. (2014) (83)
- Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice (2013) (82)
- Cellular and molecular aspects of contractile dysfunction in heart failure. (1998) (82)
- Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure. (2003) (81)
- Dichloroacetate prevents restenosis in preclinical animal models of vessel injury (2014) (81)
- G proteins and the heart (1993) (80)
- Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy (2011) (79)
- The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology (2014) (79)
- The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology (2014) (79)
- The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy. (2010) (78)
- Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes. (1997) (77)
- Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase. (1999) (75)
- The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. (2008) (74)
- In vitro perfusion of engineered heart tissue through endothelialized channels. (2013) (73)
- Original Articles: Liver Biology and PathobiologyHeme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice☆ (2003) (72)
- Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes (2015) (72)
- ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure (2019) (71)
- Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice. (2013) (71)
- Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. (1993) (70)
- Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart. (1992) (69)
- Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes (2018) (69)
- Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy (2013) (64)
- Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy (2019) (64)
- Follistatin-Like 1 in Chronic Systolic Heart Failure: A Marker of Left Ventricular Remodeling (2011) (63)
- Preserved Frank-Starling mechanism in human end stage heart failure. (1998) (63)
- Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes (2017) (63)
- Cardiac arrhythmia induced by genetic silencing of “funny” (f) channels is rescued by GIRK4 inactivation (2014) (63)
- Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts (2004) (63)
- Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis (2019) (63)
- Regulation of Cardiac cAMP Synthesis and Contractility by Nucleoside Diphosphate Kinase B/G Protein &bgr;&ggr; Dimer Complexes (2007) (62)
- Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. (2006) (62)
- Atorvastatin desensitizes β‐adrenergic signaling in cardiac myocytes via reduced isoprenylation of G‐protein γ‐subunits (2006) (62)
- Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (2020) (61)
- β-adrenergic signaling in heart failure—adapt or die (2008) (61)
- Human Induced Pluripotent Stem Cell–Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers (2018) (59)
- Role of the NO‐cGMP pathway in the muscarinic regulation of the L‐type Ca2+ current in human atrial myocytes (1998) (56)
- Embryonic stem cells for cardiac muscle engineering. (2007) (55)
- Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy (2020) (55)
- Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity. (2013) (54)
- Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial (2008) (54)
- Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. (2005) (53)
- Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? (2010) (52)
- Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling (2017) (52)
- Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia (2015) (51)
- Differential regulation of mRNA specific for beta 1- and beta 2-adrenergic receptors in human failing hearts. Evaluation of the absolute cardiac mRNA levels by two independent methods. (1996) (51)
- Myomasp/LRRC39, a Heart- and Muscle-Specific Protein, Is a Novel Component of the Sarcomeric M-Band and Is Involved in Stretch Sensing (2010) (50)
- Cardiac tissue engineering. (2002) (48)
- ATP-binding cassette transporters in human heart failure (2008) (48)
- Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure. (2008) (47)
- FHL2 expression and variants in hypertrophic cardiomyopathy (2014) (46)
- Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data (2012) (46)
- Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits. (2006) (46)
- Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. (2002) (46)
- Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. (2020) (45)
- MUSCLEMOTION (2018) (45)
- Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization. (2014) (45)
- Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling. (2011) (45)
- Methylene blue is a muscarinic antagonist in cardiac myocytes. (1997) (45)
- Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology. (2015) (45)
- Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction (2020) (44)
- Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes—a systematic review (2018) (44)
- Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function. (2004) (43)
- Alternative splicing of the primary Fas transcript generating soluble Fas antagonists is suppressed in the failing human ventricular myocardium. (1997) (43)
- Physiological antagonism between ventricular β1‐adrenoceptors and α1‐adrenoceptors but no evidence for β2‐ and β3‐adrenoceptor function in murine heart (2002) (43)
- Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects. (2009) (42)
- A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy. (2009) (42)
- Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue. (2016) (42)
- Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase. (2003) (42)
- Overexpression of wild‐type Gαi‐2 suppresses β‐adrenergic signaling in cardiac myocytes (2003) (41)
- Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae (2017) (41)
- Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes (2019) (41)
- Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia. (1996) (40)
- Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice (2012) (40)
- Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner (2021) (40)
- Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension (2002) (40)
- Effect of amiodarone on the plasma levels of metoprolol. (2004) (40)
- Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits (2018) (40)
- Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle. (1998) (39)
- The effect of mesenchymal stem cell osteoblastic differentiation on the mechanical properties of engineered bone-like tissue. (2011) (39)
- Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. (2014) (39)
- S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts (2004) (39)
- Inactivation of GiαProteins Increases Arrhythmogenic Effects ofβ-Adrenergic Stimulation in the Heart (1998) (39)
- Ca2+-Currents in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Two Different Culture Conditions (2016) (39)
- Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue (2013) (38)
- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation*♦ (2013) (38)
- Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy. (2016) (37)
- Reduction of myocardial myoglobin in bovine dilated cardiomyopathy. (1997) (37)
- Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. (2007) (37)
- Transient Expression of NMDA Receptor Subunit NR2B in the Developing Rat Heart (2000) (37)
- Generation of strip-format fibrin-based engineered heart tissue (EHT). (2014) (36)
- PDE4 in the human heart – major player or little helper? (2013) (36)
- Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts. (1992) (35)
- Activation of the cardiac endothelin system in left ventricular hypertrophy before onset of heart failure in TG(mREN2)27 rats. (2002) (35)
- General practitioners' adherence to chronic heart failure guidelines regarding medication: the GP-HF study (2016) (34)
- Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue (2016) (34)
- Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture (2018) (34)
- Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism☆ (2020) (34)
- Rat atrial engineered heart tissue: a new in vitro model to study atrial biology (2018) (34)
- Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes (2014) (32)
- Norepinephrine Upregulates Vascular Endothelial Growth Factor in Rat Cardiac Myocytes by a Paracrine Mechanism (2004) (31)
- Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes (2020) (31)
- The MLCK‐mediated α1‐adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCɛ signaling (2006) (31)
- Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue (2014) (30)
- Apparent up‐regulation of stimulatory G‐protein α subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression 1 (2000) (30)
- Distinction between two populations of islet-1-positive cells in hearts of different murine strains. (2011) (30)
- Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. (2018) (30)
- Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart (2004) (29)
- Impact of the β1‐Adrenoceptor Arg389Gly Polymorphism on Heart‐Rate Responses to Bisoprolol and Carvedilol in Heart‐Failure Patients (2012) (29)
- Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue (2019) (29)
- Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium. (1996) (28)
- S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure (2016) (28)
- Long‐term β‐adrenergic stimulation leads to downregulation of protein phosphatase inhibitor‐1 in the heart (2007) (28)
- Beta-adrenoceptor stimulation-induced increase in cardiac Gi-protein expression and in carbachol sensitivity. (1991) (28)
- Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure. (1996) (28)
- Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format (2020) (27)
- A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo (2018) (27)
- Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. (2008) (27)
- The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation. (2015) (27)
- Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins (2008) (27)
- Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy. (1995) (27)
- Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load (2010) (26)
- Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency (2020) (26)
- Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. (2005) (26)
- Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction. (2006) (26)
- DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors (2015) (25)
- Electrical coupling of cardiac myocyte cell sheets to the heart. (2006) (25)
- Intracellular β-blockade: overexpression of Gαi2 depresses the β-adrenergic response in intact myocardium (2002) (24)
- Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. (2011) (24)
- Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition. (2005) (24)
- The role of alpha 1-adrenergic and muscarinic receptors in cardiac function. (1991) (24)
- Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening. (2017) (24)
- Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance. (2008) (23)
- The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling. (2006) (23)
- Spontaneous Formation of Extensive Vessel-Like Structures in Murine Engineered Heart Tissue. (2016) (23)
- Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis (2015) (23)
- Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium. (1998) (22)
- In Vivo β-Adrenergic Stimulation Leads to Biphasic Regulation of Giα-2 Gene Transcriptional Activity in Rat Heart (1994) (22)
- Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model (2019) (22)
- Formation of Molecular Complexes by N-Methyl-d-aspartate Receptor Subunit NR2B and Ryanodine Receptor 2 in Neonatal Rat Myocard* (2004) (22)
- A novel genetic variant in the transcription factor Islet‐1 exerts gain of function on myocyte enhancer factor 2C promoter activity (2013) (22)
- An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility (2020) (21)
- Phosphodiesterase inhibition and positive inotropy in failing human myocardium. (1992) (21)
- Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive? (2020) (21)
- The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes. (2010) (21)
- The 2988G>A polymorphism affects splicing of a CYP2D6 minigene (2006) (21)
- Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation (2021) (20)
- Piezo‐bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue (2018) (20)
- Three-dimensional engineered heart tissue from neonatal rat cardiac myocytesThis work is part of the doctoral thesis of W. H. Z. at the University of Hamburg. (2000) (20)
- Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation (2019) (20)
- Myocardial tissue engineering for cardiac repair. (2016) (20)
- Markers and Mediators of Oxidative Stress (2007) (19)
- Reproducibility of transthoracic echocardiography in small animals using clinical equipment (2007) (19)
- 24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer. (2003) (19)
- Dissecting hiPSC-CM pacemaker function in a cardiac organoid model. (2019) (19)
- Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. (2003) (19)
- Vectors based on Semliki Forest virus for rapid and efficient gene transfer into non-endothelial cardiovascular cells: comparison to adenovirus. (1997) (18)
- Outcomes of Patients in Long-Term Opioid Maintenance Treatment (2016) (18)
- Analysis of gene expression patterns in small amounts of human ventricular myocardium by a multiplex RNase protection assay (1998) (18)
- Towards a Tissue-Engineered Contractile Fontan-Conduit: The Fate of Cardiac Myocytes in the Subpulmonary Circulation (2016) (17)
- Diltiazem prevents stress‐induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3‐knock‐in mice (2017) (16)
- Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization. (2008) (16)
- Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading (2013) (16)
- Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium. (1992) (16)
- Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects (2013) (16)
- Differential coupling of m-cholinoceptors to Gi/Go-proteins in failing human myocardium. (2003) (16)
- Cardiac Regeneration: New Hope for an Old Dream. (2020) (16)
- Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart (1991) (16)
- Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches (2013) (15)
- In vivo grafting of large engineered heart tissue patches for cardiac repair (2020) (15)
- Cytoprotection by the NO-Donor SNAP Against Ischemia/Reoxygenation Injury in Mouse Embryonic Stem Cell-Derived Cardiomyocytes (2014) (15)
- LQT1-phenotypes in hiPSC: Are we measuring the right thing? (2015) (15)
- Tissue engineering of aortic heart valves. (2003) (14)
- Enrichment of G protein α-subunit mRNAs in the AV-conducting system of the mammalian heart (1995) (14)
- Heart regeneration. (2016) (14)
- Epigallocatechin-3-Gallate Accelerates Relaxation and Ca2+ Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice (2016) (13)
- Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. (2016) (13)
- Pharmacokinetics of the Experimental Non‐Nucleosidic DNA Methyl Transferase Inhibitor N‐Phthalyl‐l‐Tryptophan (RG 108) in Rats (2016) (13)
- Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes (1999) (13)
- Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury (2016) (13)
- Pharmacogenetic characteristics of patients with complicated phenprocoumon dosing (2009) (13)
- Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. (2002) (12)
- Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC) (2021) (12)
- Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model. (2019) (12)
- Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats (2017) (12)
- Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart. (1991) (12)
- Evidence for CCKB receptors in the guinea-pig kidney: localization and characterization by [125I]gastrin binding studies and by RT-PCR (1998) (12)
- Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart. (2002) (12)
- A magnetics-based approach for fine-tuning afterload in engineered heart tissues. (2019) (12)
- Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1 (2015) (11)
- Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue (2019) (11)
- PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem-cell-derived cardiomyocytes. (2022) (11)
- Immunobiology of Fibrin‐Based Engineered Heart Tissue (2015) (11)
- Engineered Heart Tissue (2006) (10)
- Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition. (2007) (10)
- Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted wistar rats. (2008) (10)
- Inactivation of (Gialpha) proteins increases arrhythmogenic effects of beta-adrenergic stimulation in the heart. (1998) (10)
- Intermittent optogenetic tachypacing of atrial engineered heart tissue induces only limited electrical remodelling. (2020) (9)
- The beat goes on: human heart muscle from pluripotent stem cells. (2011) (9)
- Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation? (2021) (9)
- Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration. (2005) (9)
- Translational investigation of electrophysiology in hypertrophic cardiomyopathy (2021) (9)
- Specific 2 AR Blocker ICI 118 , 551 Actively Decreases Contraction Through a Gi-Coupled Form of the 2 AR in Myocytes From Failing Human Heart (2002) (9)
- Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium. (1998) (9)
- A New Animal Model for Investigation of Mechanical Unloading in Hypertrophic and Failing Hearts: Combination of Transverse Aortic Constriction and Heterotopic Heart Transplantation (2016) (9)
- Cardiac tissue engineering: a clinical perspective. (2007) (9)
- Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation (2020) (9)
- AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro (2017) (8)
- Normalization of force to muscle cross‐sectional area: A helpful attempt to reduce data scattering in contractility studies? (2018) (8)
- Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue (2021) (8)
- Regulation of the human Giα-2 gene promotor activity in embryonic chicken cardiomyocytes (2004) (8)
- Oral antiplatelet agents in ACS: from pharmacology to clinical differences (2011) (8)
- Preserved cardiovascular homeostasis despite blunted acetylcholine‐induced dilation in mice with endothelial muscarinic M3 receptor deletion (2019) (8)
- A new concept of fibroblast dynamics in post-myocardial infarction remodeling. (2018) (8)
- Progesterone receptor variants associated with the PROGINS haplotype exhibit functional properties similar to those of wild-type progesterone receptor (2012) (8)
- Thymosin β4 Improves Differentiation and Vascularization of EHTs (2017) (8)
- Regulation of ICa,L and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes (2020) (7)
- Enrichment of G protein alpha-subunit mRNAS in the AV-conducting system of the mammalian heart. (1995) (7)
- Characterization of the PLN p.Arg14del Mutation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (2021) (7)
- Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks (2018) (7)
- Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy (2004) (7)
- Receptor-Mediated Regulation of Cardiac Contractility: lnotropic Effects of Alpha-Adrenoceptor Stimulation with Phenylephrine and Noradrenaline in Failing Human Hearts (1996) (7)
- Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure. (1996) (7)
- Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1,4‐Dihydropyridine‐Class TGFβ Inhibitors (2019) (7)
- Human Induced Pluripotent Stem Cells for Tissue Engineered Cardiac Repair (2014) (7)
- Heart Repair With Myocytes. (2019) (7)
- Isoprenaline Stimulates Gene Transcription of the Inhibitory G Protein a-Subunit G . ia-2 in Rat Heart (2005) (7)
- Effect of captopril on myocardial beta-adrenoceptor density and Gi alpha-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy. (1995) (7)
- Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca) (2020) (7)
- B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice. (2013) (6)
- Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress? (2010) (6)
- xpression of ten RGS proteins in human myocardium : functional characterization of an upregulation of RGS 4 in heart failure (2002) (6)
- Cell Banking of hiPSCs: A Practical Guide to Cryopreservation and Quality Control in Basic Research. (2020) (6)
- Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart. (2015) (5)
- The German Centre for Cardiovascular Research. (2012) (5)
- Protection by the NO-Donor SNAP and BNP against Hypoxia/Reoxygenation in Rat Engineered Heart Tissue (2015) (5)
- Paradoxical Effects on Force Generation after Efficient β1-Adrenoceptor Knockdown in Reconstituted Heart Tissue (2014) (5)
- Cardiovascular Research in Germany. (2017) (5)
- Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts. (2004) (5)
- Dissociation of the effects of forskolin and dibutyryl cAMP on force of contraction and phospholamban phosphorylation in human heart failure. (1999) (5)
- β1 Adrenoceptor antagonistic effects of the supposedly selective β2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts (2015) (5)
- Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes. (1996) (5)
- and ESC CRT R&D and European Affairs Work Shop on Personalized Medicine (2014) (5)
- No impact of sex and age on beta‐adrenoceptor‐mediated inotropy in human right atrial trabeculae (2020) (5)
- Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy (2022) (5)
- Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue (2019) (5)
- Human engineered heart tissue transplantation in a guinea pig chronic injury model. (2022) (4)
- FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo (2021) (4)
- Poster session 2 (2004) (4)
- [Personalized therapy in cardiology. Biomarkers, pharmacogenetics and therapy of monogenic diseases]. (2013) (4)
- [Vernakalant: a novel antiarrhythmic drug for the rapid conversion of atrial fibrillation to sinus rhythm]. (2010) (4)
- Prolonged action potentials in HCM-derived iPSC--biology or artefact? (2015) (4)
- Heart regeneration: from mouse to human (2020) (4)
- Comprehensive analyses of the inotropic compound omecamtiv mecarbil in rat and human cardiac preparations. (2022) (4)
- Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT). (2011) (4)
- Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study (2020) (3)
- Regulation of basal and norepinephrine-induced cAMP and ICa in hiPSC-cardiomyocytes: Effects of culture conditions and comparison to adult human atrial cardiomyocytes. (2021) (3)
- Statins Do More Than Lower Cholesterol-Depending on What You Eat? (2021) (3)
- New tissue for failing hearts (2013) (3)
- Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy. (2019) (3)
- BS27 Development and preclinical testing of a large heart muscle patch (2019) (3)
- [Overview of drug interactions. Combining drugs correctly!]. (2000) (3)
- Treatments targeting inotropy A position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology (2019) (3)
- Correction: Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load (2011) (3)
- Regulation of Cardiac cAMP Synthesis and Contractility by Nucleoside Diphosphate Kinase B/G Protein (cid:1)(cid:2) Dimer Complexes (2007) (3)
- Abstract 5292: Adrenergic Stress Unmasks Exaggerated Septal Hypertrophy and Proteasome Impairment in Heterozygous cMyBP-C Mutant Mice (2008) (3)
- A frequent gene polymorphism affecting the heart-rate response to carvedilol. (2013) (3)
- Development of a biological ventricular assist device (BioVAD) (2009) (3)
- Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance (2013) (3)
- ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes (2021) (3)
- Alterations of the ubiquitin–proteasome system in cardiomyopathic cMyBP-C mice (2007) (3)
- Abstract 3457: Derivation of Functional Cardiomyocytes from Parthenogenetic Stem Cells (2008) (3)
- Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (2021) (3)
- How to repair a broken heart with pluripotent stem cell-derived cardiomyocytes. (2021) (3)
- [Genetic polymorphisms in drug metabolizing enzymes--impact on treatment with beta-blockers]. (2004) (3)
- Position Paper of the ESC Working Group Cellular Biology of the Heart : Cell-Based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure (2016) (3)
- Human engineered heart tissue transplantation in a guinea pig chronic injury model (2021) (3)
- Brief communication Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure (2007) (2)
- Tissue Engineering of Cardiac Muscle (2008) (2)
- Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease. (2021) (2)
- Abstract 2279: Fibroblasts Are Essential for the Generation of Embryonic Stem Cell Derived Bioengineered Myocardium (2009) (2)
- Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease (2021) (2)
- Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury (2022) (2)
- Tissue-Engineered Cardiovascular Products (2014) (2)
- Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response (2014) (2)
- Abstract 9013: Myeloperoxidase is Critically Linked to the Development of Diastolic Heart Failure Following Pressure Overload (2011) (2)
- An epidemiological study exploring a possible impact of treatment with ACE inhibitors or angiotensin receptor blockers on ACE2 plasma concentrations (2020) (2)
- Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo (2017) (2)
- Brief communication Adenovirus-delivered short hairpin RNA targeting PKCα improves contractile function in reconstituted heart tissue (2007) (2)
- Abstract 918: Evidence of Alterations of the Ubiquitin-Proteasome System in Mouse Models of Familial Hypertrophic Cardiomyopathy (2006) (2)
- Poster Session 2 (2009) (2)
- Regulation of APD and Force by the Na+/Ca2+ Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue (2022) (2)
- [Changes in gene expression in terminal myocardial failure]. (1992) (2)
- Muscarinic Receptor Activation Reduces Force and Arrhythmias in Human Atria Independent of IK,ACh (2022) (2)
- Engineered heart tissue for replacement therapy (2002) (2)
- 433Metabolomics in translational medicine - A link between acylcarnitines and atrial fibrillation (2018) (2)
- Correction: Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue (2018) (2)
- Improved method for autoradiographic localization of ß-adrenoceptors using photoaffinity labelling (1993) (2)
- I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model (2015) (2)
- Exaggerated Cardiotoxicity of Sunitinib in Stressed 3-Dimensional Heart Muscles∗ (2018) (2)
- A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue (2022) (2)
- A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM (2023) (2)
- Comparison of Human Induced Pluripotent Stem Cells Cultured at Different Oxygen Concentrations by Proteomic Analysis Suggests Normoxia-induced Cellular Senescence (2022) (2)
- Development of recipient-matched engineered heart tissue using 3D printing (2014) (2)
- [Fingolimod - a new immunomodulator]. (2009) (1)
- [Emergencies in the practice. Hazards of "mix syringe"]. (2001) (1)
- ESC Working Group on Cellular Biology of the Heart Position paper for Cardiovascular Research Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure (2018) (1)
- Oral abstract presentations & Young Investigators Competition (2012) (1)
- Nonsense-mediated mRNA decay degrades cMyBP-C mutants in cardiomyopathic mice (2007) (1)
- Late-breaking Basic Science Abstracts from the American Heart Association's Scientific Sessions 2012 2012 Late-breaking Basic Science Abstracts Late-breaking Basic Science Oral Session 22925 Cardiac Myosin Binding Protein C Is an Ultra-early and Cardiac-specific Biomarker of Myocardial Necrosis Repl (2012) (1)
- Liquid-phase isoelectric focusing of cardiac proteins: differential separation of cMyBP-C phosphorylation states (2007) (1)
- ‘Corrigendum to “Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia” [Molecular Metabolism 5 (2) (2015) 67–78]’ (2020) (1)
- Fibrin-based engineered heart tissue for cardiac repair: Initial results after transplantation (2011) (1)
- G protein mRNA in left ventricular hypertrophy and heart failure (1992) (1)
- P368Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes (2014) (1)
- Enhanced Myocardial Repair with CardioChimeras (2013) (1)
- Author Correction: Differentiation of cardiomyocytes and generation of human engineered heart tissue (2019) (1)
- Transfection studies using a new cardiac 3D gel system (2000) (1)
- Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes (2022) (1)
- ESGCT XXV Anniversary Congress in Collaboration with the German Society for Gene Therapy October 17-20, 2017 Berlin, Germany. (2017) (1)
- Oxygen diffusion in fibrin-based engineered heart tissue and the effect of artificial oxygen carriers (2013) (1)
- Recapitulation of dyssynchrony-associated contractile impairment in asymmetrically paced engineered heart tissue (2021) (1)
- No effect of thymosin beta‐4 on the expression of the transcription factor Islet‐1 in the adult murine heart (2018) (1)
- Human iPS-cell-derived Engineered Heart Tissue for Cardiac Repair (2014) (1)
- Prevascularization and in vitro perfusion of engineered heart tissue (2013) (1)
- Generation of bi-allelic MYBPC3 truncating mutant and isogenic control from an iPSC line of a patient with hypertrophic cardiomyopathy. (2021) (1)
- Electrophysiological Investigations of Human iPS Cell-Derived Engineered Heart Tissue in a Guinea Pig Infarction Model (2016) (1)
- Is Stimulation of Cardiomyocyte Renewal a Facette of Reversible Catecholamine Toxicity? (2016) (1)
- Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading (2013) (1)
- Abstract 1096: Cytokine Enhancement with Hgf Or Vegf in the Infarct Border Zone is Key to Attenuating the Negative Remodelling after Myocardial Infarction (2008) (1)
- HGF or VEGF gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction (2010) (1)
- Activation of an accessory pathway of glucose metabolism to treat dilated cardiomyopathy. (2022) (1)
- Abstract 19079: Specific Skipping of Exons Using Antisense Oligoribonucleotides Results in a Novel Molecule in cMyBP-C Knock-in Mouse Myocytes (2010) (1)
- In vivo beta-adrenergic stimulation leads to biphasic regulation of Gi alpha-2 gene transcriptional activity in rat heart. (1994) (1)
- P236Evaluation of safety and feasibility of Mybpc3 gene therapy in a mouse model of hypertrophic cardiomyopathy (2014) (1)
- Resting membrane potential is less negative in trabeculae from right atrial appendages of women, but action potential duration does not shorten with age. (2023) (1)
- Molecular Determinants of Altered Ca 2 (cid:1) Handling in Human Chronic Atrial Fibrillation (2006) (0)
- Abstract 11908: Assessment of Immunobiology of Fibrin-based Engineered Heart Tissue (2012) (0)
- Functional In Vitro Myocardial Performance in Patients with Aortic Disease (2019) (0)
- CRISPR/Cas9 genome editing repairs a novel ACTN2 mutation and prevents the disease phenotype in human iPSC-derived cardiomyocytes and engineered heart tissue (2018) (0)
- Phospholamban and troponin I phosphorylation in remodeled left atria from patients with sinus rhythm and chronic atrial fibrillation (2006) (0)
- Contribution of the CYP2D6 genotype to the occurrence of side-effects and of therapeutic failure during treatment with CYP2D6-dependent antidepressants (2004) (0)
- Human-Engineered Atrial Tissue for Studying Atrial Fibrillation. (2022) (0)
- OP-EUJC220111 1..8 (2022) (0)
- Multi-Well Engineered Heart Tissue for Drug Screening and Predictive Toxicology (2012) (0)
- Abstract 766: Effect Of The Arg389Gly-Polymorphism On Exercise-Induced Tachycardia: Genotype-Effects Are Subject To A Diurnal Variation (2007) (0)
- [Beta blockers in cardiac insufficiency. When, how much and which substance]. (2004) (0)
- Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1 (2014) (0)
- The role of protein phosphatase inhibitor 1 in the initial phase after transverse aortic constriction in a murine model (2011) (0)
- Modelling aberrant microtubule De-/Tyrosination in HiPSC-derived engineered heart tissues (2022) (0)
- With several loops engineered heart muscle tissue (2006) (0)
- Evaluation of the cardioprotective potential of Buckberg vs. Bretschneider cardioplegia in neonatal pig left-ventricle cardiac muscle tissue (2005) (0)
- Cellular Ca2+ Handling in Cardiac Atrophy and Hypertrophy (2014) (0)
- Matrix body for the measurement of isometric force parameters of cell tissue, method of producing the matrix body, set for this method and the use of the matrix body for culturing cardiomyocytes (1995) (0)
- Abstract 2272: Blunted Exercise-induced Left Ventricular Hypertrophy in Heterozygous cMyBP-C Knock-in Mutant Mice (2009) (0)
- Poster Session 3 (2012) (0)
- P1587Retinoic acid-treated HIPSC-CM: a suitable model for human atrium? (2017) (0)
- 632 Clinical Aspects in Regenerative Medicine: Immunobiology of Engineered Heart Tissue (2012) (0)
- Saturday, 17 July 2010 (2010) (0)
- 405: Cytokine Enhancement with HGF or VEGF in the Infarct Border Zone Is Key to Attenuating the Negative Remodelling after Myocardial Infarction (2009) (0)
- Failing Fontan: Towards a Subpulmonary Neo-ventricle from Engineered Heart Tissue (2015) (0)
- Abstract 12435: Lack of Ca2+ Sensitization Induced by EMD 53998 in Engineered Heart Tissue Derived From Mybpc3-Knock-In and Mybpc3-Knock-Out Mice (2011) (0)
- Institute of Experimental and Clinical Pharmacology and Toxicology Clinical Pharmacology (2007) (0)
- P678S-glutathiolation of cMyBP-C reduces its phosphorylation and contributes to impairment of cardiac myocyte contractile function (2014) (0)
- Effects of Akrinor and Its Constituents on Basal and Norepinephrine Increased Tone in Human Internal Mammary Arteries (2017) (0)
- Valvular Cardiomyopathy in Aortic Valve Regurgitation Correlates with Myocardial Fibrosis (2023) (0)
- Inducible and cardiac specific inhibitor-1 overexpression enhances contractile performance in the murine heart (2008) (0)
- 10th international symposium on gastrointestinal hormones santa barbara, california, USA August 27–31, 1994 (2005) (0)
- Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice (2011) (0)
- Antagonism of NAADP mediated calcium signaling ameliorates arrythmias in the heart (2012) (0)
- Cancer therapeutic drug guide (0)
- Two-Cell type cardiac tissue engineering for screening of anti-fibrotic interventions (2020) (0)
- Valvular Cardiomyopathy in Aortic Valve Disease Correlates with Myocardial Fibrosis (2023) (0)
- Dimensional tissue for cardiac mammals, synthetically manufactured and method of manufacturing the same. (2001) (0)
- Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density (2017) (0)
- The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies. (2023) (0)
- The Influence of DNA Methyl Transferase Inhibition in a Rat Model of Pressure-Overload Cardiac Hypertrophy (2015) (0)
- 670 Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial (2008) (0)
- Engineered heart tissue and optogenetics – A powerful and versatile combination (2022) (0)
- Immature human engineered heart tissues engraft in a guinea pig chronic injury model (2022) (0)
- [Cardiac biomarkers and their clinical relevance]. (2023) (0)
- 3D Culture of Human Muscle Cells Modulates Cell-Matrix Adhesions and Actin Cytoskeleton Organization (2012) (0)
- Culture conditions effect properties of the Na+/K+-ATPase pump current in hiPSC cardiomyocytes (2021) (0)
- Poster session 3 (2001) (0)
- 7DNA methylation patterns at promoters of hypertrophy-associated genes in an engineered heart tissue model of cardiac hypertrophy (2014) (0)
- Left ventricular wall replacement with engineered heart tissue in heterotopically transplanted rat hearts (2008) (0)
- Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes—a systematic review (2018) (0)
- Advancement of a biological ventricular assist device (Bio VAD (2010) (0)
- Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats (2017) (0)
- P5385Development and preclinical testing of upscaled engineered heart tissue for use in translational studies (2019) (0)
- Front Cover: Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1,4‐Dihydropyridine‐Class TGFβ Inhibitors (ChemMedChem 8/2019) (2019) (0)
- Kardiales Tissue Engineering (2003) (0)
- Functional and electrical integration of engineered heart tissue in a native rat heart (2006) (0)
- PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation (2023) (0)
- OBSOLETE: Myocardial Repair (2018) (0)
- From basic science to high performance medicine. (2018) (0)
- Assessment of immunobiology of engineered heart tissue using bioluminescence imaging (2011) (0)
- Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes. (2021) (0)
- Generation of implantable 3D skeletal muscle tissue from human embryonic stem cells and muscular dystrophy iPS cells (2016) (0)
- A novel hypoxia-reoxygenation model to study the protective effect of hypoxia or opioid perconditioning using cardiac tissue engineering and induced pluripotemt stem cell techonology (2020) (0)
- Human cardiac myosin-binding protein C frameshift mutations result in marked decrease of protein expression (2002) (0)
- Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response (2014) (0)
- Human iPSC-derived multi-cell-type engineered heart tissues as an advanced model for pathological hypertrophy (2022) (0)
- 5923A link between acylcarnitines and atrial fibrillation (2018) (0)
- Human Ventricular Tissue for Experimental Studies: A New Source? (2020) (0)
- Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model (2019) (0)
- Regulation of APD and force by Na+/Ca2+ exchanger in hiPSC-cardiomyocytes (2022) (0)
- [Dopamine: less important in emergency medicine?]. (2007) (0)
- Reduced contractile response to α1-adrenergic stimulation in atria from mice with chronic cardiac CaMKII inhibition (2007) (0)
- The Role of the Mechanorezeptor Piezo2 in Cardiac Mechanosensation (2019) (0)
- Abstract 19161: cAMP Regulated Transcriptional Coactivator 1 - A Novel Player in Cardiac Hypertrophy (2015) (0)
- What is the immunologic impact after transplantation of a novel fibrin-based type of engineered heart tissue? (2013) (0)
- Engineering Cardiovascular Regeneration (2015) (0)
- Development of an Atrioventricular (AV) conduction block in the rat- investigation tool for effects of heart failure (2013) (0)
- Cardiac Remodeling in Cardiomyocyte-Specific PIEZO2 Knock-Out Mice (2021) (0)
- Stem cells and heart tissue engineering. (2007) (0)
- A role for NAADP in mouse cardiac myocyte calcium signalling (2007) (0)
- Blinded analysis of CiPA compounds with human engineered heart tissue (2018) (0)
- Generation of human engineered heart tissue with a chemo- and optogenetic Off-On switch (2022) (0)
- pluripotent stem cells Cardiac Tissue Engineering State of the Art (0)
- [Cardiology 2018 : From basic science to high efficiency medicine]. (2018) (0)
- Abstract P192: MicroRNA-199b Targets the Nuclear Kinase Dyrk1a in an Auto-Amplification Loop Promoting Calcineurin/NFAT Signaling (2011) (0)
- [Drug interactions in the practice. Which combinations are taboo?]. (2001) (0)
- Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation (2019) (0)
- The mutation R400Q in mitofusin 2 impairs in vitro cardiac differentiation of human induced pluripotent stem cells and induces fibrosis in engineered heart tissues (2022) (0)
- Myocytes From Failing Human Heart (2002) (0)
- Magnetic Adjustment of Afterload in Engineered Heart Tissues. (2020) (0)
- Engineering Heart Tissue for In Vitro and In Vivo Studies (2005) (0)
- Cardiomyocytological Phosphorylation Alterations in Mechanical Unloaded Hypertrophic and Failing Hearts (2017) (0)
- Regenerative cellular therapy: Positive remodeling after myocardial infarction using iv injected mesenchymal stem cells and cytokine enhancement (2009) (0)
- Melusin protects from cardiac rupture and improves functional remodelling in mice after myocardial infarction (2013) (0)
- Ventricular arrhythmias and remodeling in a mouse model of hypertrophic cardiomyopathy (2018) (0)
- Age-Dependent Increase in AF Cannot Be Explained by Shortening of Action Potential Duration (2022) (0)
- Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks (2018) (0)
- Abstract 1471: Development and Characterization of Force Generating Human Engineered Heart Tissue from Embryonic Stem Cells (2007) (0)
- Journals on the move : launch of the ESC Journals App (2012) (0)
- Non-Nucleoside DNA Methyltransferase Inhibition Attenuates Pressure Overload Induced Cardiac Hypertrophy in Rats (2017) (0)
- Implantation of Spontaneously Beating Human iPS Cell-Derived ENGINEERED HEART TISSUE Does Not Provoke Ventricular Arrhythmias in a Guinea Pig Infarction Model (2017) (0)
- Coupling of (cid:98) 2 -Adrenoceptor to G i Proteins and Its Physiological Relevance in Murine Cardiac Myocytes (1999) (0)
- β1 Adrenoceptor Antagonistic Effects of ICI 118,551 on the Positive Inotropic Effect of Adrenaline in Murine Hearts (2016) (0)
- Abstract 17175: Phoshodiesterase 2 - A New Member Of Proteins Involved In Beta-adrenergic Desensitization (2013) (0)
- Evaluation of fibrin-based engineered heart tissue (FBEHT) as potential future strategy towards cardiac regeneration (2010) (0)
- Postnatal Isl1+ progeny can be purified and cultivated from Isl1-Cre/R26-YFP mice (2008) (0)
- Fontan Circulation: Generation of a Subpulmonary Neo-Ventricle from Engineered Heart Tissue (2015) (0)
- Modelling LMNA-cardiomyopathy with patient-specific human iPSC-derived engineered heart tissue and a partial rescue by gene replacement therapy (2022) (0)
- InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility (2017) (0)
- Why Valvular Cardiomyopathy May Persist after Surgery? A Joint Basic Science—Clinical Effort (2020) (0)
- PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes (2021) (0)
- Abstract 2712: Development of a Biological Ventricular Assist Device (2006) (0)
- [Interview by Anne-Katrin Döbler]. (2013) (0)
- Engineering Cardiovascular Regeneration (2015) (0)
- The unfolded protein response in Mybpc3-targeted mice with hypertrophic cardiomyopathy (2011) (0)
- Abstract 16949: Failing Fontan: Genesis of a Subpulmonary Neo-ventricle From Engineered Heart Tissue (2015) (0)
- IK,ACh Does Not Mediate Negative Inotropy and Antiarrhythmic Action of Muscarinic Receptor Activation in Human Atrium (2021) (0)
- Evaluation of Cardiomyocyte Proliferation after Transplantation of Engineered Heart Tissue Patches. (2020) (0)
- Regional differences of G protein alpha-subunit mRNA expression in the heart and other tissues (1994) (0)
- CYP2D6-Genotyping in clinical practice: Impact of Genotyp on serum concentrations of psychiatric relevant CYP2D6-substrates (2004) (0)
- P635Proarrhythmic drugs exert hERG-independent slowing of relaxation and irregular beating in rat engineered heart tissue (2014) (0)
- Abstract 445: Phosphatase Inhibitor-1 is Critically Involved in Acute and Chronic Catecholamine Stress Responses (2006) (0)
- Abstract 1855: Transmural Myocardial Repair with Engineered Heart Tissue Grafts (2007) (0)
- 0252: Bradycardia and arrhythmia caused by cardiac-specific suppression of the “funny” (If) current are rescued by Girk (2014) (0)
- 103Properties of the sodium-calcium exchanger and the Na+/K+-ATPase in human induced pluripotent stem cell-derived cardiomyocytes (2017) (0)
- (1176) - Non-Nucleosidic DNA Methyl Transferase Inhibition Attenuates Pressure Overload Induced Cardiac Hypertrophy in Rats (2017) (0)
- Hypoxia to Stimulate Cardiomyocyte Proliferation After MI? A Word of Caution. (2023) (0)
- Studying inotropic compound effects in relatively mature human iPSC-derived cardiomyocytes using 2D and 3D models (2018) (0)
- Role of calmodulin kinase II in inotropic effect of {alpha}1-adrenergic stimulation in the heart (2008) (0)
- Tropomyosin Phosphorylation Plays a Crucial Role in Cardiac Remodeling and Re-remodeling (2016) (0)
- Impact of oxygen concentrations on engineered heart tissue development (2011) (0)
- Transplanted iPSC-derived cardiomyocytes actively contribute to left ventricular function (2022) (0)
- Abstract 5517: A Novel Tissue Engineered Skeletal Muscle Screening Platform to Assess the Myotoxic Potential of Statins (2008) (0)
- Proteomic Analysis in Valvular Cardiomyopathy: Aortic Regurgitation vs. Aortic Stenosis (2023) (0)
- Characterisation of angiogenesis in fibrin-based engineered heart tissue using a VECadherin-Cre-ERT2xRosa26R mouse model (2012) (0)
- Less Negative Resting Membrane Potential in Women's Atria: Protection against Atrial Fibrillation? (2023) (0)
- SERCA2a gain of function in patient-derived R14Del hiPSC-CMs. (2021) (0)
- GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY (2017) (0)
- Scattered endothelial cells in engineered heart tissue reassemble and form a dense capillary-like network (2010) (0)
- Abstract 14035: Autophagy is Regulated by mir-106b in the Heart (2014) (0)
- Engineered heart tissue with a pharmacological off-switch as a tool to study the influence of cardiac work on cardiomyocyte maturation (2022) (0)
- Abstract 3278: Myoscape (Muscle Specific Calcium-Channel Associated Protein) is a Novel Striated Muscle Enriched Gene Regulating Calcium Cycling and Contractile Function (2009) (0)
- Contractile force of transplanted cardiomyocytes contributes to heart function after injury (2021) (0)
- Development of a Subpulmonary Neoventricle from Engineered Heart Tissue for the Treatment of Univentricular Heart Defects (2022) (0)
- A simple and flexible platform for optogenetic pacing in cardiac tissue engineering (2022) (0)
- P1079A versatile tool for measuring contraction of adult and human pluripotent stem cell-derived cardiomyocytes in vitro and cardiac muscle in situ (2017) (0)
- Characterization of a novel interaction between four-and-a-half-LIM domains 2 and cardiomyopathy-associated protein 5 in cardiac myocytes (2020) (0)
- DNA methyl transferase 3A loss in human engineered heart tissue induces distinct alterations of contractility (2020) (0)
- Enhanced Ca2+ Influx through Cardiac L-Type Ca2+ Channels Maintains the Systolic Ca2+ Transient in Cardiac Unloading (2013) (0)
- P425Cytoprotection by the NO-donor SNAP and BNP against ischemia/reperfusion injury in rat engineered heart tissue (2014) (0)
- P5992Why aortic valve disease may persist after surgery? A joint basic science - Clinical effort (2019) (0)
- G.P.122 Heterozygous LmnadelK32 mutant mice showed alterations of the ubiquitin–proteasome system and developed dilated cardiomyopathy (2012) (0)
- Functional characterisation of a patient-derived laminopathy model in human engineered heart tissues recapitulates fibrosis and mechanical decoupling defect (2022) (0)
- 331 Adenoviral expression of human 5‐HT4 receptors in rat adult cardiac myocytes (2003) (0)
- P5839Patient-specific iPSC-derived cardiomyocytes reveal a disease-causing role of an ACTN2 mutation in HCM and an unexpected LQT phenotype (2017) (0)
- Investigation of ventricular arrhythmia mechanisms in hypertrophic cardiomyopathy in mice and men (2020) (0)
- Role of calmodulin kinase II in inotropic effect of α1‐adrenergic stimulation in the heart (2008) (0)
- Adenoviral gi-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae (2002) (0)
- The clinical atlas of cardiomyopathies: data from the prospective DZHK TORCH study (2020) (0)
- Specific &bgr;2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the &bgr;2AR in Myocytes From Failing Human Heart (2002) (0)
- Difference in cardioprotective potential of Buckberg v. Bretschneider cardioplegia in neonatal pig left-ventricle cardiac muscle tissue, by evaluation of the ex vivo isovolumetric contraction pattern (2004) (0)
- Positive Inotropic Effects of Akrinor® in Human Atrial Tissue: Relevant PDE Inhibition at Clinically Used Concentration (2016) (0)
- Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective (2023) (0)
- Chapter Eighty-Two – Tissue-Engineered Cardiovascular Products (2007) (0)
- P778Physiological and pharmacological characterization of human engineered heart tissue (2014) (0)
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What Schools Are Affiliated With Thomas Eschenhagen?
Thomas Eschenhagen is affiliated with the following schools:
