Thomas Helleday
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Biology
Thomas Helleday's Degrees
- Masters Biotechnology Uppsala University
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(Suggest an Edit or Addition)Thomas Helleday's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase (2005) (3742)
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints (2006) (1882)
- DNA repair pathways as targets for cancer therapy (2008) (1550)
- Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair (2010) (752)
- Replication stress links structural and numerical cancer chromosomal instability (2013) (697)
- Mechanisms underlying mutational signatures in human cancers (2014) (675)
- DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007) (671)
- The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings (2011) (671)
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase (2007) (659)
- The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (2005) (640)
- PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination (2009) (559)
- Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage (2005) (546)
- miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. (2011) (429)
- DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. (2001) (419)
- Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 (2005) (408)
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (2014) (405)
- Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells (2014) (374)
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks (2005) (363)
- Pathways of mammalian replication fork restart (2010) (354)
- SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability (2014) (353)
- Pathways for mitotic homologous recombination in mammalian cells. (2003) (329)
- Spontaneous Homologous Recombination Is Induced by Collapsed Replication Forks That Are Caused by Endogenous DNA Single-Strand Breaks (2005) (329)
- Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy (2014) (323)
- Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2 (2010) (323)
- Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. (2003) (302)
- Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity (2018) (296)
- Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. (2004) (286)
- Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. (2012) (284)
- PCNA on the crossroad of cancer. (2009) (278)
- Chk1 promotes replication fork progression by controlling replication initiation (2010) (273)
- Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate (2010) (271)
- Homologous recombination in cancer development, treatment and development of drug resistance. (2010) (265)
- Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells (2002) (260)
- The histone methyltransferase SET8 is required for S-phase progression (2007) (225)
- Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress (2013) (222)
- Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. (2010) (212)
- Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. (2010) (209)
- Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair (2006) (195)
- Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy (2005) (184)
- The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells (2007) (173)
- Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase (2010) (163)
- PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA* (2010) (155)
- Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer (2017) (144)
- Managing COVID-19 in the oncology clinic and avoiding the distraction effect (2020) (143)
- Brominated flame retardants induce intragenic recombination in mammalian cells. (1999) (141)
- Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control (2008) (138)
- PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy (2011) (134)
- Claspin promotes normal replication fork rates in human cells. (2008) (123)
- Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer (2018) (121)
- Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation (2018) (120)
- UV stalled replication forks restart by re-priming in human fibroblasts (2011) (120)
- RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. (2003) (117)
- PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription. (2015) (115)
- The DNA Damaging Revolution: PARP Inhibitors and Beyond. (2019) (115)
- A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. (2010) (113)
- 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. (2010) (109)
- Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments (2018) (107)
- Targeting homologous recombination repair defects in cancer. (2010) (107)
- Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients (2010) (105)
- The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links (2009) (104)
- Validation and development of MTH1 inhibitors for treatment of cancer. (2016) (103)
- The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer (2003) (101)
- Rational design and validation of a Tip60 histone acetyltransferase inhibitor (2014) (101)
- Processing of protein ADP-ribosylation by Nudix hydrolases. (2015) (99)
- Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies (2016) (99)
- Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. (2005) (98)
- Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells (2007) (98)
- Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. (2009) (96)
- Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies (2017) (96)
- Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival (2012) (92)
- Identification of the MMS22L-TONSL complex that promotes homologous recombination. (2010) (90)
- ATM is required for the cellular response to thymidine induced replication fork stress. (2004) (89)
- Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. (2015) (86)
- Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma (2017) (85)
- RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair (2007) (85)
- A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family (2017) (85)
- Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 (2015) (85)
- WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. (2008) (83)
- Crystal structure of human MTH1 and the 8‐oxo‐dGMP product complex (2011) (82)
- NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine. (2016) (82)
- Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. (2010) (78)
- Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (2015) (78)
- Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination. (2009) (77)
- The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells. (1999) (76)
- Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. (2002) (75)
- XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. (2010) (73)
- RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells. (2007) (73)
- The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions (2014) (72)
- Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair (2015) (69)
- DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair. (2016) (69)
- Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity (2013) (69)
- Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation (2012) (64)
- Drugging DNA repair (2016) (64)
- Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells (2000) (63)
- Zinc binding catalytic domain of human tankyrase 1. (2008) (61)
- 5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair (2013) (60)
- Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination (2018) (60)
- Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox. (2015) (60)
- Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (2016) (60)
- Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer (2013) (60)
- Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells. (2000) (59)
- ATM‐mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double‐strand break repair (2011) (59)
- p53 protects from replication-associated DNA double-strand breaks in mammalian cells (2004) (59)
- SAMHD1 protects cancer cells from various nucleoside-based antimetabolites (2017) (53)
- Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents. (2004) (52)
- A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination. (1998) (51)
- Pathways controlling dNTP pools to maintain genome stability. (2016) (51)
- Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. (2017) (50)
- Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells. (2006) (46)
- Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. (2003) (45)
- Global survey of the immunomodulatory potential of common drugs (2017) (45)
- The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair (2014) (44)
- U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden (2017) (43)
- The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing (2016) (42)
- Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks (2014) (42)
- FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ (2011) (42)
- PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites (2016) (41)
- Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11 (2008) (40)
- Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility. (2006) (40)
- Targeting BER enzymes in cancer therapy. (2018) (38)
- PARP inhibitor receives FDA breakthrough therapy designation in castration resistant prostate cancer: beyond germline BRCA mutations. (2016) (38)
- With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. (2017) (38)
- CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. (2011) (37)
- Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells. (1998) (37)
- SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways (2013) (36)
- Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (2018) (36)
- PathwAX: a web server for network crosstalk based pathway annotation (2016) (36)
- Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks (2010) (36)
- Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition. (2016) (36)
- DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer. (2003) (36)
- Early replication fragile sites: where replication–transcription collisions cause genetic instability (2013) (35)
- A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma (2018) (35)
- RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis (2007) (34)
- ATM/Wip1 activities at chromatin control Plk1 re‐activation to determine G2 checkpoint duration (2017) (34)
- N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells (2012) (34)
- A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation (2016) (33)
- BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells (2009) (33)
- Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy. (2008) (33)
- Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. (2016) (33)
- The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity (2019) (32)
- Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair. (2013) (32)
- Spatially resolved clonal copy number alterations in benign and malignant tissue (2022) (32)
- An orthotopic glioblastoma animal model suitable for high-throughput screenings (2018) (31)
- Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction (2011) (31)
- Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry. (2015) (31)
- Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. (2011) (31)
- Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells (2011) (29)
- Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics (2018) (28)
- A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives (2013) (28)
- Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) Regulates γ-Histone 2AX (γ-H2AX) Levels upon Ionizing Radiation* (2012) (28)
- Castration therapy of prostate cancer results in downregulation of HIF-1α levels. (2012) (28)
- Mre 11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA 2 and PARP 1 (2012) (28)
- dUTPase inhibition augments replication defects of 5-Fluorouracil (2017) (28)
- Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy. (2013) (27)
- ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination. (2001) (27)
- A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair (2015) (27)
- Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space. (2017) (26)
- The Relationship Between Homologous Recombination Repair and the Sensitivity of Human Epidermis to the Size of Daily Doses Over a 5-Week Course of Breast Radiotherapy (2012) (25)
- Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion (2016) (25)
- RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors. (2001) (24)
- Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment. (2012) (24)
- Chemical strategies for development of ATR inhibitors (2014) (23)
- Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs (2019) (23)
- Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy (2020) (22)
- Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice (2013) (22)
- CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation (2012) (22)
- Karonudib is a promising anticancer therapy in hepatocellular carcinoma (2019) (22)
- Targeting OGG1 arrests cancer cell proliferation by inducing replication stress (2020) (21)
- PrimPol breaks replication barriers (2013) (20)
- Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress (2014) (20)
- Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks (2016) (20)
- Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells (2004) (20)
- MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells (2019) (19)
- DNA repair as treatment target. (2011) (19)
- A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. (2003) (19)
- hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia (2016) (19)
- Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminants. (2004) (19)
- Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival. (2014) (19)
- Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles. (2015) (19)
- Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy (2012) (18)
- Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair (2008) (18)
- E2F-7 couples DNA damage-dependent transcription with the DNA repair process (2013) (18)
- Human RECQL5 overcomes thymidine-induced replication stress. (2010) (18)
- Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia–Related Head and Neck Cancer (2020) (18)
- Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines. (2006) (18)
- TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model (2020) (17)
- Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. (2017) (17)
- Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 (2017) (17)
- Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (17)
- In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization (2019) (16)
- Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics* (2020) (16)
- Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects (2020) (16)
- AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma (2020) (16)
- Identification of novel small molecules that inhibit STAT3-dependent transcription and function (2017) (15)
- DNA damage response in peritumoral regions of oesophageal cancer microenvironment. (2013) (15)
- Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level (2017) (15)
- Making immunotherapy 'cold' tumours 'hot' by chemotherapy-induced mutations-a misconception. (2019) (15)
- A Convenient Microwave‐Assisted Propylphosphonic Anhydride (T3P®) Mediated One‐Pot Pyrazolone Synthesis (2013) (15)
- Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses (2020) (14)
- Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination. (2017) (14)
- Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids (2020) (14)
- Further consideration of the incidence of childhood Leukaemia around nuclear power plants in Great Britain. (COMARE Fourteenth report) (2011) (13)
- Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. (2017) (13)
- OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions (2020) (13)
- MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP (2018) (13)
- Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function (2022) (13)
- Computational and Experimental Druggability Assessment of Human DNA Glycosylases (2019) (12)
- Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. (2015) (12)
- MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG (2020) (12)
- NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis (2021) (12)
- Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds (2020) (12)
- A facile and efficient synthesis of tetrahydro-β-carbolines (2013) (12)
- Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells (2012) (11)
- Poisoning Cancer Cells with Oxidized Nucleosides. (2015) (11)
- Further consideration of the incidence of cancers around the nuclear installations at Sellafield and Dounreay (2016) (11)
- Development of a chemical probe against NUDT15 (2020) (11)
- STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions (2018) (10)
- Chemotherapy-induced toxicity-a secondary effect caused by released DNA? (2017) (10)
- Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta. (2012) (10)
- Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress (2022) (10)
- Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. (2018) (9)
- Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis (2018) (9)
- Transcription Inhibition by DRB Potentiates Recombinational Repair of UV Lesions in Mammalian Cells (2011) (9)
- Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. (2018) (8)
- NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487 (2021) (8)
- Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination. (2009) (8)
- Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements. (2016) (8)
- Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target (2020) (8)
- MTH1 inhibitors for the treatment of psoriasis. (2021) (8)
- Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response (2015) (8)
- Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma (2021) (8)
- The XPD subunit of TFIIH is required for transcription-associated but not DNA double-strand break-induced recombination in mammalian cells. (2010) (8)
- Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival (2011) (7)
- DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy. (2007) (7)
- The results of conservative (fertility-sparing) treatment in borderline ovarian tumors vary depending on age and histological type (2014) (7)
- The spatial landscape of clonal somatic mutations in benign and malignant tissue (2021) (7)
- MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool (2020) (6)
- Bacteriophage P2 integrase: another possible tool for site‐specific recombination in eukaryotic cells (2008) (6)
- A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate (2018) (6)
- Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma (2020) (6)
- NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. (2021) (6)
- Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation (2018) (6)
- CHK 1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation (2012) (6)
- Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion (2021) (5)
- Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells. (2011) (5)
- Restriction of AID activity and somatic hypermutation by PARP-1 (2019) (5)
- Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model (2021) (5)
- Targeting the DNA damage response and repair in cancer through nucleotide metabolism (2022) (5)
- MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia (2021) (5)
- The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions (2018) (4)
- Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana. (2019) (4)
- Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase) (2016) (4)
- Minor structural modifications to alchemix influence mechanism of action and pharmacological activity. (2012) (4)
- Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival. (2014) (4)
- Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity (2021) (4)
- Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks (2012) (3)
- Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma (2020) (3)
- NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. (2022) (3)
- 1180 Effects of MTH1 inhibitor TH1579 on cutaneous melanoma (2018) (3)
- OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells (2022) (3)
- PCNA (proliferating cell nuclear antigen) (2012) (3)
- Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities Report of an NCI Workshop held September 1–3, 2010 (2011) (3)
- Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems. (2017) (3)
- Pharmacological OGG1 inhibition decreases murine allergic airway inflammation (2022) (3)
- The DRAG Test: An Assay for Detection of Genotoxic Damage (2001) (3)
- DNA repair pathways as target for cancer therapy (2012) (3)
- The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (2022) (3)
- Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma (2017) (2)
- Polθ inhibitors unchained (2021) (2)
- Double-Strand Break Repair via Double Holliday Junctions (Szostak Model) (2007) (2)
- Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles. (2020) (2)
- Inhibition of oxidized nucleotide sanitation by TH1579 and conventional chemotherapy cooperatively enhance oxidative DNA-damage and survival in AML. (2022) (2)
- Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines. (2017) (2)
- MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells (2021) (2)
- P047 Castration promotes radiosensitivity by direct regulation of DNA repair in prostate cancer (2014) (2)
- Mutagenesis: Mutating a Gene While Reading It (2010) (2)
- An ATM/Wip1-dependent timer controls the minimal duration of a DNA-damage mediated cell cycle arrest (2016) (2)
- Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction. (2017) (2)
- Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ (2011) (2)
- Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (2019) (2)
- 332 POLQ (DNA polyermase theta) as a novel therapeutic target: preclinical and clinical data (2010) (2)
- MetaCNV - a consensus approach to infer accurate copy numbers from low coverage data (2019) (2)
- New Translational Possibilities for Microenvironmental Modulation of Radiosensitivity (2011) (2)
- MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells (2021) (2)
- High content drug screening for Fanconi anemia therapeutics (2020) (2)
- Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells. (2002) (1)
- A New Concise Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives. (2014) (1)
- A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P®) Mediated One-Pot Pyrazolone Synthesis. (2014) (1)
- Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm. (2017) (1)
- Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics. (2020) (1)
- Caffeine delays replication fork progression and enhances UV induced homologous recombination induced in Chinese hamster cell lines. (2006) (1)
- The first structure of an active mammalian dCTPase and its complexes with substrate analogues and products. (2020) (1)
- Ex vivo culture of circulating tumour cell derived explants to facilitate rapid therapy testing in small cell lung cancer (2016) (1)
- An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation (2022) (1)
- Abstract #1708: Voreloxin is active in breast cancer biopsies and potency is enhanced in a BRCA2 mutant background (2009) (1)
- Session 1: signal transduction. (1998) (1)
- Clinical Strategies for PARP Inhibitors beyondHomologous Recombination Deficiency (2018) (1)
- Structure of NUDT15 in complex with 6-thio-GMP (2016) (1)
- Abstract ES12-2: Targeted DNA repair in cancer and new NUDT5 inhibitors to block hormone signalling to target breast cancer (2020) (1)
- Radiation Resistance in Cancer Therapy: Meeting (2011) (1)
- Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir (2022) (1)
- Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B) (2008) (1)
- Co-expression of MTH1 and PMS2 is associated with advanced disease and disease progression after therapy in melanoma. (2021) (1)
- Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones (2022) (1)
- P XVII B.13 Interaction of fatty acids in mutagenicity (1997) (0)
- CHK1 activity is required for replication fork elongation but not stabilisation after UV irradiation (2011) (0)
- Timeless interacts with Parp1 to promote DNA DSB repair (2016) (0)
- Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma (2019) (0)
- Targeting DNA Repair in Anti-Cancer Treatments (2018) (0)
- Crystal structure of mouse MTH1 with 8-oxo-dGTP (2018) (0)
- Abstract CN05-04: Novel DNA repair targets for anticancer treatments. (2013) (0)
- Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines. (2017) (0)
- Inhibitors of DNA Repair and Response to Ionising Radiation (2011) (0)
- Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy (2023) (0)
- Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer (2022) (0)
- PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. (2012) (0)
- Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel (2023) (0)
- Effect of chloride ion on solubility and dissolution of a basic drug and salt form for oral delivery (2018) (0)
- Alkylating DNA Lesions Associated with Replication are Repaired by Homologous Recombination in Mammalian Cells (2004) (0)
- Structure of NUDT15 in complex with Ganciclovir triphosphate (2021) (0)
- Development of small molecule NUDT22 inhibitors for uses in cancer. (2021) (0)
- Spatio-temporal analysis of prostate tumors in situ suggests the pre-existence of ADT-resistance (2020) (0)
- Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell (2016) (0)
- UNIVERSITY OF TARTU FACULTY OF SCIENCE AND TECHNOLOGY INSTITUTE OF MOLECULAR AND CELL BIOLOGY (2016) (0)
- Replication progression is retarded only at very high doses of ionizing radiation independently of check-point signalling (2006) (0)
- MEASUREMENT OF DNA REPAIR PROTEINS IN RELATION TO DISEASE BIOMARKERS AND DRUG DEVELOPMENT | NIST (2015) (0)
- Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity (2018) (0)
- 240 The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells (2014) (0)
- CHAPTER 12 – Inhibition of DNA repair as a therapeutic target (2008) (0)
- Editor's Note: Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer (2021) (0)
- Radiotherapy fraction size sensitivity is modulated by DNA repair systems (2010) (0)
- Corrigendum: Replication stress links structural and numerical cancer chromosomal instability (2013) (0)
- Crystal structure of human MTH1 in complex with inhibitor 6-[(2-phenylethyl)sulfanyl]-7H-purin-2-amine (2017) (0)
- RAD51C(Rad51L2) is involved in maintaining homologous recombination and centrosome number in mitosis (2005) (0)
- Treatment for cancer. (2007) (0)
- Abstract 1057: Targeting MTHFD2 using first-in-class inhibitors kills haematological and solid cancer through thymineless-induced replication stress (2020) (0)
- Structure of human MTH1 in complex with TH287 (2014) (0)
- 156 Exploiting cancer defects in targeted therapy (2009) (0)
- Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM (2022) (0)
- OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice (2022) (0)
- The role of Topoisomerase II in replication in mammalian cells (2011) (0)
- Gefitinib andAfatinib ShowPotential Efficacy for Fanconi Anemia–Related Head and Neck Cancer (2020) (0)
- Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675 (2018) (0)
- Abstract 4799: OGG1 depleted cancer cells are sensitive to anti-malarial drug proguanil: Repurposing for cancer treatment (2020) (0)
- The three methyls: the function and therapeutic potential of histone H3K36 trimethylation (2014) (0)
- Crystal structure of zebrafish MTH1 in complex with TH588 (2016) (0)
- Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588 (2018) (0)
- Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium (2020) (0)
- Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer (2016) (0)
- Acute MUS 81 depletion leads to replication fork slowing and a constitutive DNA damage response (2015) (0)
- Mitotic defect in XRCC3 variant T241M in relation to cancer susceptibility (2005) (0)
- Introducing a new method for absolute quantification of DNA repair proteins in relation to drug development: LC–MS/MS with isotope dilution (2016) (0)
- Front Cover: Optimization of N ‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023) (2023) (0)
- Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 (2020) (0)
- HUMAN PFKFB3 IN COMPLEX WITH KAN0438241 (2018) (0)
- Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma (2020) (0)
- Environmental Contaminants, Recombination and Cancer : Investigations on the molecular mechanisms of spontaneous and induced recombination in the hprt gene of Chinese hamster cells (1999) (0)
- Polymerase η proficiency sensitises cells to 6-thioguanine (2011) (0)
- Anti-proliferative effects of taurine conjugated fatty acids (2009) (0)
- Precision oncology using ex vivo technology: a step towards individualised cancer care? (2022) (0)
- NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir (2021) (0)
- Human SHMT2 in complex with pemetrexed (2019) (0)
- Human octameric PAICS in complex with CAIR and SAICAR (2020) (0)
- Abstract 5204: Targeting OGG1 arrest cancer cell proliferationby mitochondrial dysfunction and replication stress (2020) (0)
- Native Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 (2018) (0)
- Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. (2011) (0)
- A Facile and Efficient Synthesis of Tetrahydro‐β‐carbolines. (2013) (0)
- CK2 phosphorylation of XRCC1 facilitate single-strand break formation during base excision repair (2011) (0)
- Use of agents that inhibit homologous recombination for the treatment of cancer (2008) (0)
- P-128 Regulation of RAD51 levels in response to etoposide (VP16) induced DNA strand breaks in small cell lung cancer cells (2003) (0)
- The use of inhibitory RNA in PARP activity in the manufacture of a medicament for the treatment of cancer (2004) (0)
- Methods in Molecular Biology, Vol. 262: Genetic Recombination Reviews and Protocols. Edited by Alan S. Waldman. (2004) (0)
- Functional and inhibition studies on 2-oxoglutarate-dependent oxygenases (2012) (0)
- P VIII.8 Recombinogenic effects may diverge depending on different recombination mechanisms (1997) (0)
- PARP and DNA-PK Recruit XRCC1 to Stalled Replication Forks to Mediate Repair (2016) (0)
- 247 INVITED PARP Inhibitors Sensitivity and Resistance (2011) (0)
- Cancer Genomics in the Clinic: Methods and Lessons (2013) (0)
- Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer (2017) (0)
- Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming (2023) (0)
- Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies (2022) (0)
- Abstract CT182: OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer (2023) (0)
- The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity (2019) (0)
- Towards targeting SAMHD 1 to improve cytarabine therapy for hematological malignancies (2018) (0)
- The role of DNA polymerase eta in determining cellular responses to chemo-radiation treatment (2013) (0)
- Cytotoxicity of novel alkylating anthraquinones in cells with DNA nucleotide excision repair and DNA mismatch repair defects (2007) (0)
- Crystal structure of human MTH1 in complex with 8-oxo-dGMP (2011) (0)
- Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525 (2019) (0)
- A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family (2017) (0)
- Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination (2018) (0)
- RNAi2010: Gene Regulation by Small RNAs : Selected Abstracts (2010) (0)
- Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. (2017) (0)
- Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1 (2023) (0)
- NUDT22 promotes cancer growth through pyrimidine salvage (2023) (0)
- The role of LATS1 in DNA damage signalling (2012) (0)
- MP45-14 THE SPATIAL LANDSCAPE OF CLONAL SOMATIC MUTATIONS IN BENIGN AND MALIGNANT PROSTATE EPITHELIA (2022) (0)
- Ionizing radiation induces replication-associated secondary DNA double-strand breaks that are substrates for homologous recombination repair (2011) (0)
- Crystal structure of human MTH1 in complex with inhibitor 7-(furan-2-yl)-5-methyl-1,3-benzoxazol-2-amine (2017) (0)
- Structure of human MTH1 in complex with TH588 (2014) (0)
- Therapeutic Discovery Targeted Mutations in the ATR Pathway De fi ne Agent-Speci fi c Requirements for Cancer Cell Growth and Survival (2011) (0)
- MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression (2019) (0)
- Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma (2020) (0)
- UV-induced replication fork collapse in DNA polymerase η deficient cells is independent of the MUS81 endonuclease (2011) (0)
- A. thaliana NUDT1 in complex with 8-oxo-dGTP (2019) (0)
- Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (2021) (0)
- Human SHMT2 in complex with lometrexol (2019) (0)
- UVC–stalled replication forks readily collapse into DNA double-strand breaksin the absence of DNA polymerase η and independently of Mus81 in humancells (2011) (0)
- P635: TARGETING THE ONE-CARBON METABOLISM AS NOVEL THERAPEUTIC STRATEGY IN CHRONIC LYMPHOCYTIC LEUKEMIA (2022) (0)
- 6: Targeting MTH1 prevents sanitation of oxidised dNTP pools and causes cancer-selective DNA damage and cell death (2014) (0)
- Crystal structure of human MTH1 in complex with fragment inhibitor 8-(methylsulfanyl)-7H-purin-6-amine (2017) (0)
- Crystal structure of human Nudt15 (MTH2) (2015) (0)
- Crystal structure of mouse MTH1 in complex with TH588 (2018) (0)
- O6.5MTH1 inhibitors in cancer treatment (2015) (0)
- Spatio-temporal analysis of prostate tumours suggests the pre-existence of ADT-resistant expression clones (2020) (0)
- SMG-1 regulates senescence and suppresses epithelial-mesenchymal transition (2013) (0)
- Crystal structure of human MTH1 in complex with N6-methyl-dAMP (2020) (0)
- MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells (2021) (0)
- Cell-based phenotypic screens to identify modulators of sensitivity to N-methyl-N'-nitro-N-nitrosoguanidine (2011) (0)
- Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells (2023) (0)
- The spatial landscape of clonal somatic mutations in benign and malignant prostate epithelia (2022) (0)
- Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. (2023) (0)
- Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (2018) (0)
- PF230 THE RNA HELICASE DDX17 PROTECTS ACUTE MYELOID LEUKEMIA CELLS AGAINST DNA DAMAGE (2019) (0)
- A Transcriptome Atlas of a Cross Section of a Multifocal Prostate Cancer (2020) (0)
- Crystal structure of zebrafish MTH1 in complex with O6-methyl-dGMP (2018) (0)
- Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor KU0058948 (2008) (0)
- Crystal structure of human MTH1 in complex with O6-methyl-dGMP (2018) (0)
- Crystal structure of human MTH1 (2011) (0)
- EACR Young Cancer Researcher Award (2008) (0)
- Abstract 3932: Loss of PTEN sensitizes cells to DNA damaging agents in a RAD51-independent manner (2010) (0)
- Therapeutics , Targets , and Chemical Biology Cancer Research 6-Thioguanine Selectively Kills BRCA 2-Defective Tumors and Overcomes PARP Inhibitor Resistance (2010) (0)
- Caffeine delays replication fork progression and enhances homologous recombination induced in Chinese hamster cell lines by UV-irradiation (2005) (0)
- CHD1: a new treatment biomarker for recombination deficiency in castration resistant prostate cancer? (2017) (0)
- 365: The interplay between the redox environment, MTH1 and cancer (2014) (0)
- Structure of NUDT15 in complex with inhibitor TH1760 (2020) (0)
- Extreme Expressions of DNA Repair Proteins APE1 and MTH1, in Human Breast Cancer as Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry (2015) (0)
- Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors (2016) (0)
- Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101 (2023) (0)
- 835: Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool (2014) (0)
- 119 EACR award DNA replication repair: molecular insights towards new approaches to targeted anti-cancer therapy (2007) (0)
- Abstract A115: Contextual synthetic lethality: Repair‐deficient hypoxic tumor cells are sensitized to poly(ADP‐ribose) polymerase (PARP) inhibition (2009) (0)
- Structure of NUDT15 in complex with inhibitor TH8321 (2021) (0)
- A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma (2018) (0)
- Abstract IA12: Poisoning cancer with oxidized nucleotides by targeting MTH1 (2017) (0)
- Front Cover: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (ChemMedChem 18/2022) (2022) (0)
- NEIL3-mediated mitotic base excision repair of oxidative lesions at telomeres prevents senescence in hepatocellular carcinoma (2021) (0)
- Using the PARP inhibitory activity of RNAi for the manufacture of a medicament for the treatment of cancer. (2004) (0)
- Overexpression of the scaffoldWD40 proteinWRAP53β enhances the repair of and cell survival from DNA double-strand breaks (2020) (0)
- MetaCNV - a consensus approach to infer accurate copy numbers from low coverage data (2020) (0)
- Transcription-associated UV-induced DNA damage triggers futile homologous recombination repair in mammalian cells (2010) (0)
- Crystal structure of dog MTH1 protein (2018) (0)
- Two recombination pathways involved in repair of alkylated lesions (2005) (0)
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