Thomas Jenuwein
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German scientist
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Thomas Jenuweinbiology Degrees
Biology
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Molecular Biology
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#732
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Genetics
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#854
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Biology
Thomas Jenuwein's Degrees
- PhD Molecular Biology University of Vienna
Why Is Thomas Jenuwein Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thomas Jenuwein is a German scientist working in the fields of epigenetics, chromatin biology, gene regulation and genome function. Biography Thomas Jenuwein received his Ph.D. in molecular biology in 1987 from the EMBL, working on fos oncogenes in the laboratory of Rolf Müller and the University of Heidelberg and performed postdoctoral studies on the immunoglobulin heavy chain enhancer with Rudolf Grosschedl at the University of California San Francisco . As an independent group leader and then as a senior scientist at the Research Institute of Molecular Pathology in Vienna, he focused his research to chromatin regulation. Through this work, he and his team discovered the first histone lysine methyltransferase that was published in 2000. He is currently director at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany where he heads the Department of Epigenetics. From 2004 to 2009, he coordinated the EU-funded network of excellence 'The Epigenome' , which connected more than 80 laboratories in Europe. Jenuwein is also co-editor of the first textbook on 'Epigenetics' that was published by Cold Spring Harbor Laboratory Press in 2007 and 2015. He is an ambassador for the dissemination of Science and is actively engaged with public lectures and radio and TV documentations to inform lay audiences about 'Epigenetics'.
Thomas Jenuwein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Translating the Histone Code (2001) (9385)
- Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins (2001) (2844)
- Regulation of chromatin structure by site-specific histone H3 methyltransferases (2000) (2820)
- Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer (2005) (1822)
- Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability (2001) (1673)
- The molecular hallmarks of epigenetic control (2016) (1637)
- Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. (2005) (1350)
- Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin (2003) (1254)
- Oncogene-induced senescence as an initial barrier in lymphoma development (2005) (1182)
- Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. (2003) (1160)
- A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. (2004) (1113)
- A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing (2007) (1100)
- Rb targets histone H3 methylation and HP1 to promoters (2001) (942)
- The many faces of histone lysine methylation. (2002) (868)
- Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression (2002) (793)
- Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. (2007) (751)
- p53 is regulated by the lysine demethylase LSD1 (2007) (716)
- Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. (2006) (708)
- An epigenetic road map for histone lysine methylation (2003) (685)
- Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. (2003) (676)
- The profile of repeat‐associated histone lysine methylation states in the mouse epigenome (2005) (673)
- Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component (2002) (666)
- Central role of Drosophila SU(VAR)3–9 in histone H3‐K9 methylation and heterochromatic gene silencing (2002) (640)
- Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding (2003) (616)
- Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression (2007) (589)
- Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases (2004) (566)
- Repression of p53 activity by Smyd2-mediated methylation (2006) (566)
- The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development (2001) (533)
- Epigenetic Marking Correlates with Developmental Potential in Cloned Bovine Preimplantation Embryos (2003) (524)
- Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin (2002) (508)
- Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. (2004) (489)
- Functional mammalian homologues of the Drosophila PEV‐modifier Su(var)3‐9 encode centromere‐associated proteins which complex with the heterochromatin component M31 (1999) (465)
- A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. (2008) (421)
- Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing (2006) (419)
- Silencing by plant Polycomb‐group genes requires dispersed trimethylation of histone H3 at lysine 27 (2006) (406)
- SET domain proteins modulate chromatin domains in eu- and heterochromatin (1998) (398)
- The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development (2001) (395)
- Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. (2006) (388)
- A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation (2004) (381)
- Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3 (2004) (379)
- The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
- In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases (2012) (349)
- Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin (2005) (347)
- G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53* (2010) (341)
- Re-SET-ting heterochromatin by histone methyltransferases. (2001) (327)
- Arabidopsis REF6 is a histone H3 lysine 27 demethylase (2011) (321)
- Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana (2004) (318)
- Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development (2003) (317)
- Mammalian homologues of the Polycomb‐group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres (1997) (308)
- Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. (2004) (301)
- Isolation and Characterization ofSuv39h2, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression (2000) (297)
- Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. (2006) (294)
- Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity (2012) (284)
- Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination (2007) (259)
- Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. (2007) (256)
- Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells. (2014) (253)
- The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation (1989) (248)
- Extension of chromatin accessibility by nuclear matrix attachment regions (1997) (248)
- Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. (2007) (248)
- H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. (2009) (243)
- The epigenetic magic of histone lysine methylation (2006) (237)
- Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions. (1994) (219)
- Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis (2005) (209)
- Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression (2000) (205)
- PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation (2010) (203)
- Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. (2011) (203)
- Moving AHEAD with an international human epigenome project (2008) (202)
- Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins*S⃞ (2009) (195)
- Histone H3 Lysine 9 Methylation Occurs Rapidly at the Onset of Random X Chromosome Inactivation (2002) (181)
- The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function*♦ (2006) (171)
- A transcription factor–based mechanism for mouse heterochromatin formation (2012) (168)
- Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. (2007) (168)
- EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells* (2005) (160)
- Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. (2010) (157)
- Acetate Promotes T Cell Effector Function during Glucose Restriction. (2019) (156)
- A Crack in Histone Lysine Methylation (2004) (155)
- Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity (2016) (149)
- A silencing pathway to induce H 3K 9 and H 4K 20 trimethylation at constitutive heterochromatin (2004) (134)
- ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes (2015) (133)
- Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program (2016) (133)
- Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. (2009) (133)
- Formation of facultative heterochromatin in the absence of HP1 (2003) (130)
- H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification (2019) (122)
- Histone modification patterns associated with the human X chromosome (2006) (121)
- Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. (2000) (118)
- Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes (2004) (117)
- DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. (2007) (116)
- The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. (1993) (115)
- Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation (2017) (114)
- Generation and characterization of methyl-lysine histone antibodies. (2004) (102)
- Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin (2016) (101)
- Mammalian Su(var) genes in chromatin control. (2010) (100)
- Selective Interactions between Vertebrate Polycomb Homologs and the SUV39H1 Histone Lysine Methyltransferase Suggest that Histone H3-K9 Methylation Contributes to Chromosomal Targeting of Polycomb Group Proteins (2002) (98)
- Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome. (2004) (95)
- Overview and Concepts (2000) (93)
- Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. (1991) (92)
- Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. (2013) (91)
- Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair (2014) (88)
- The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats (2017) (81)
- PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse (2008) (80)
- An RNA-Guided Pathway for the Epigenome (2002) (71)
- Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV (1985) (71)
- Di-methyl H4 Lysine 20 Targets the Checkpoint Protein Crb2 to Sites of DNA Damage* (2008) (70)
- Structure-function analysis of fos protein: A single amino acid change activates the immortalizing potential of v-fos (1987) (67)
- Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte (2005) (65)
- Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice (2001) (65)
- MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output (2010) (64)
- The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction (2017) (64)
- Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes (2006) (59)
- Activation of the β globin locus by transcription factors and chromatin modifiers (2000) (54)
- Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3 (2020) (48)
- The indexing potential of histone lysine methylation. (2004) (46)
- H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction (2020) (43)
- The role of histone modifications in epigenetic transitions during normal and perturbed development. (2006) (43)
- Recruitment of PRC 1 function at the initiation of X inactivation independent of PRC 2 and silencing (2013) (41)
- Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8 (2006) (41)
- The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice (2017) (40)
- Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity (2019) (38)
- SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway (2018) (36)
- Tumor Stroma-Derived TGF-b Limits Myc-Driven Lymphomagenesis via Suv 39 h 1-Dependent Senescence (2009) (36)
- Isolation and structural analysis of a biologically active chicken c-fos cDNA: identification of evolutionarily conserved domains in fos protein. (1987) (33)
- Molecular biology. An RNA-guided pathway for the epigenome. (2002) (29)
- The Histone Methyltransferase Suv39h1 Increases Class Switch Recombination Specifically to IgA1 (2006) (29)
- Dual histone H 3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE (2013) (29)
- Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. (2020) (27)
- Trim 28 Haploinsufficiency Triggers Bistable Epigenetic Obesity Graphical (2016) (24)
- Complete loss of H3K9 methylation dissolves mouse heterochromatin organization (2021) (21)
- DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH 2 (2007) (18)
- The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse Chromosomes 11 and 6 (1999) (16)
- Multiple regions of v-Fos protein involved in the activation of AP1-dependent transcription: is trans-activation crucial for transformation? (1991) (13)
- m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin (2021) (12)
- Nuclear matrix attachment regions confer long-range function upon the immunoglobulin mu enhancer. (1998) (12)
- Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation. (1995) (9)
- A transcription factor–based mechanism for mouse heterochromatin formation (2013) (7)
- MDM 2 recruitment of lysine methyltransferases regulates p 53 transcriptional output (2010) (7)
- Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia (2020) (5)
- SIRT 6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv 39 h 1 regulates the NF-κB pathway (2017) (5)
- An LKB1–mitochondria axis controls TH17 effector function (2022) (5)
- Role of enhancer sequences in regulating accessibility of DNA in nuclear chromatin. (1993) (4)
- The Histone Methyltransferase Suv 39 h 1 Increases Class Switch Recombination Specifically to IgA 1 (2006) (4)
- Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis (2020) (3)
- G9a and Glp methylate lysine 373 in the tumor suppressor p53. (2010) (3)
- The fos Oncogene and Transformation (1986) (2)
- Faculty Opinions recommendation of Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. (2002) (2)
- Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3 (2011) (2)
- Faculty Opinions recommendation of New histone incorporation marks sites of UV repair in human cells. (2006) (1)
- Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis (2022) (1)
- Faculty Opinions recommendation of LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. (2005) (1)
- Faculty Opinions recommendation of RNA polymerase IV directs silencing of endogenous DNA. (2005) (0)
- Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia (2021) (0)
- Impaired Histone H3 Lysine 9 Methylation Accelerates Ras-Driven Lymphomagenesis by Disabling Cellular Senescence. (2004) (0)
- Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8 (2014) (0)
- Inactivation of the Suv39h1 Histone Methyltransferase Accelerates Myc-Driven B-Cell Lymphomagenesis and Compromises Drug-Inducible Cellular Senescence. (2005) (0)
- Genes de regulation de la chromatine (1996) (0)
- Epigenetic control by histone methylation (2007) (0)
- SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway (2018) (0)
- Regulation of p53 activity by the lysine demethylase KDM7A (2015) (0)
- Faculty Opinions recommendation of A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. (2003) (0)
- Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3 (2020) (0)
- Faculty Opinions recommendation of The role of DNA methylation in setting up chromatin structure during development. (2003) (0)
- Faculty Opinions recommendation of Dot1p modulates silencing in yeast by methylation of the nucleosome core. (2002) (0)
- ATRX Plays a Key Role in M aintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes Graphical (2018) (0)
- Faculty Opinions recommendation of An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. (2003) (0)
- Faculty Opinions recommendation of mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. (2003) (0)
- Double‐strand break repair functions of 53BP1 (2009) (0)
- Author response: Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation (2017) (0)
- ChIP Mapping of H3K27m3, H4K20m1, H3K9m2, H3K4m3, and H3K4m2 on the Xist -Expressing Chromosome 11 during Differentiation of Clone 36 ES Cells (2013) (0)
- Analysis of the Function of the fos Oncogene Product (1987) (0)
- Structure Function Analysis of fos Protein (2020) (0)
- Explorer Nuclear Architecture Organized by Rif 1 Underpins the Replication-Timing Program (2016) (0)
- Faculty Opinions recommendation of mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. (2003) (0)
- Faculty Opinions recommendation of DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. (2002) (0)
- Faculty Opinions recommendation of GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. (2005) (0)
- Faculty Opinions recommendation of Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. (2003) (0)
- Modular screening method for the stability of chromosomes dependent methyltransferase. (2001) (0)
- 500. THE MANIPULATION OF THE EPIGENETIC MARK HISTONE 3 LYSINE 9 TRIMETHYLATION IN DONOR CELLS AND ITS EFFECTS ON THE DEVELOPMENT OF CLONED MOUSE EMBRYOS (2009) (0)
- C S H L " E P I G E N E T I C S " T E X T B O O K 2 0 0 6 Overview (2005) (0)
- Genes regulating chromatin. (1996) (0)
- Comprar Epigenetics | Thomas Jenuwein | 9780879697242 | CSHL Press (2007) (0)
- Faculty Opinions recommendation of Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. (2002) (0)
- DEV115667 3431..3436 (2014) (0)
- Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis (2020) (0)
- Apoptotic Lymphoma Cells Evoke a Pro-Senescent Stromal Signal That Limits Lymphoma Development. (2009) (0)
- NUCLEAR DYNAMICS AND EPIGENETIC MARKS OF TRANSCRIPTION IN MANTLE CELL LYMPHOMA (0)
- Genetic and molecular analysis of position-effect variegation (PEV) modifier genes and their role un chromatin regulation (1997) (0)
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