Thomas Kilduff
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American neuroscientist and sleep researcher
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Thomas Kilduffbiology Degrees
Biology
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#11845
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Neuroscience
#1959
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#2015
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Biology
Thomas Kilduff's Degrees
- PhD Neuroscience Stanford University
- Doctorate Medicine Stanford University
Why Is Thomas Kilduff Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thomas S. Kilduff is an American neuroscientist and the director of SRI International's Center for Neuroscience. He specializes in neurobiology related to sleep and wakefulness, and was involved in the discovery of hypocretin , a neuropeptide system that is highly involved in wakefulness regulation.
Thomas Kilduff's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. (1998) (3542)
- Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems (1998) (3208)
- Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system (1999) (586)
- Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin (1998) (545)
- The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders (2000) (441)
- Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response (2004) (408)
- A role for cryptochromes in sleep regulation (2002) (265)
- Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat (2001) (238)
- Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice (2011) (214)
- A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight (2013) (201)
- Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1A Receptor (2004) (195)
- Optogenetic Manipulation of Activity and Temporally Controlled Cell-Specific Ablation Reveal a Role for MCH Neurons in Sleep/Wake Regulation (2014) (174)
- Identification of a population of sleep-active cerebral cortex neurons (2008) (165)
- Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function (2014) (162)
- The Neurobiology of Sleep and Wakefulness. (2015) (148)
- Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics (2012) (138)
- Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep (2003) (137)
- Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture (2009) (130)
- Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study (2006) (128)
- Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. (2006) (124)
- Sleep Deprivation Effects on Circadian Clock Gene Expression in the Cerebral Cortex Parallel Electroencephalographic Differences among Mouse Strains (2008) (124)
- The relationship of local cerebral glucose utilization to optical density ratios (1983) (120)
- Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. (2008) (118)
- Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone (2012) (116)
- Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice (1991) (111)
- Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor (2005) (111)
- Muscarinic cholinergic receptors and the canine model of narcolepsy. (1986) (109)
- REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories (2019) (109)
- Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus. (1992) (105)
- A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity (2013) (104)
- Immune response gene expression increases in the aging murine hippocampus (2002) (103)
- GABAB receptor‐mediated modulation of hypocretin/orexin neurones in mouse hypothalamus (2006) (103)
- GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. (1995) (100)
- Molecular and Anatomical Signatures of Sleep Deprivation in the Mouse Brain (2010) (94)
- Gene Expression in the Brain across the Hibernation Cycle (1999) (94)
- Engineering Materials Technology (1985) (93)
- Transcriptional regulation of the mouse fatty acid amide hydrolase gene. (2002) (92)
- Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. (2008) (89)
- Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation? (2011) (87)
- Immediate early gene expression in brain during sleep deprivation: preliminary observations. (1993) (86)
- Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area (1999) (85)
- Mapping of the mRNAs for the hypocretin/orexin and melanin‐concentrating hormone receptors: Networks of overlapping peptide systems (2001) (82)
- Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression (2015) (81)
- Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease. (2013) (81)
- Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats (1993) (81)
- [14C]2-deoxyglucose uptake in ground squirrel brain during hibernation (1982) (76)
- Region-specific changes in immediate early gene expression in response to sleep deprivation and recovery sleep in the mouse brain (2003) (76)
- Thyrotropin-Releasing Hormone Increases Behavioral Arousal through Modulation of Hypocretin/Orexin Neurons (2009) (75)
- Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain (2002) (75)
- Cholinergically induced REM sleep triggers Fos-like immunoreactivity in dorsolateral pontine regions associated with REM sleep (1992) (69)
- Comparison of hypocretin/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain (2004) (65)
- Sequence and tissue distribution of a candidate G-coupled receptor cloned from rat hypothalamus. (1995) (62)
- Biogenic amine concentrations in the brains of normal and narcoleptic canines: current status. (1986) (60)
- Sleep and mammalian hibernation: homologous adaptations and homologous processes? (1993) (59)
- Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. (2013) (57)
- Brain dopamine receptor levels elevated in canine narcolepsy (1987) (56)
- Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline‐induced release of melatonin (2001) (53)
- GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy (2014) (53)
- Nicotine and nicotinic receptors in the circadian system (1998) (52)
- Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy. (2019) (49)
- Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus (2003) (49)
- Challenges in the development of therapeutics for narcolepsy (2017) (48)
- Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. (2013) (47)
- Melatonin influences Fos expression in the rat suprachiasmatic. (1992) (47)
- Prepro-hypocretin (prepro-orexin) expression is unaffected by short-term sleep deprivation in rats and mice. (2000) (47)
- Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. (2013) (40)
- Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep–Wake Physiology (2017) (40)
- Ontogeny of photic-induced c-fos mRNA expression in rat suprachiasmatic nuclei. (1994) (40)
- Sleep fragmentation in canine narcolepsy. (1986) (40)
- Suprachiasmatic nuclei influence hibernation rhythms of golden-mantled ground squirrels (1990) (39)
- Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics (2017) (37)
- Age-related changes in histamine receptor mRNA levels in the mouse brain (2004) (36)
- C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation (1994) (36)
- Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions. (1999) (34)
- The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats (2014) (32)
- Nicotine administration differentially affects gene expression in the maternal and fetal circadian clock. (1995) (31)
- Characterization of the Circadian System of NGFI-A and NGFI-A/NGFI-B Deficient Mice (1998) (30)
- Narcolepsy without unique MHC class II antigen association: studies in the canine model. (1989) (29)
- Further characterization of sleep-active neuronal nitric oxide synthase neurons in the mouse brain (2010) (29)
- Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease. (2016) (28)
- Engineering Materials Technology: Structures, Processing, Properties & Selection (1994) (28)
- Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species (2012) (28)
- New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology (2008) (27)
- Homeostatic Sleep Pressure is the Primary Factor for Activation of Cortical nNOS/NK1 Neurons (2015) (25)
- Evidence for excessive sleepiness in canine narcoleptics. (1986) (25)
- Mapping the Hypocretin/Orexin Neuronal System: An Unexpectedly Productive Journey (2017) (24)
- Molecular genetic advances in sleep research and their relevance to sleep medicine. (2005) (24)
- Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain (2016) (24)
- Suprachiasmatic nucleus: phase-dependent activation during the hibernation cycle. (1989) (23)
- Modulation of the promoter region of prepro-hypocretin by α-interferon (2001) (22)
- Daily variation of CNS gene expression in nocturnal vs. diurnal rodents and in the developing rat brain. (1997) (21)
- Gene expression in the rat cerebral cortex: Comparison of recovery sleep and hypnotic-induced sleep (2006) (21)
- Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition (2017) (21)
- Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder (2017) (20)
- Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy. (1986) (20)
- Regional changes in central monoamine and metabolite levels during the hibernation cycle in the golden-mantled ground squirrel (1991) (19)
- Hypocretin/orexin: maintenance of wakefulness and a multiplicity of other roles. (2005) (19)
- Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs. (1989) (19)
- Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. (2010) (18)
- Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep123 (2016) (17)
- Acute Cognitive Effects of the Hypocretin Receptor Antagonist Almorexant Relative to Zolpidem and Placebo: A Randomized Clinical Trial. (2020) (17)
- Relative 2-deoxyglucose uptake of the paratrigeminal nucleus increases during hibernation (1983) (17)
- Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy (2019) (17)
- The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems (2016) (16)
- Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep? (2011) (16)
- Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. (2021) (15)
- What Rest in Flies Can Tell Us about Sleep in Mammals (2000) (15)
- Modulation of the promoter region of prepro-hypocretin by alpha-interferon. (2001) (14)
- Animal care practices in experiments on biological rhythms and sleep: report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society. (2013) (14)
- HSP70 expression is increased during the day in a diurnal animal, the golden-mantled ground squirrelSpermophilus lateralis (1999) (13)
- Neuropeptide B induces slow wave sleep in mice. (2011) (13)
- The wake-promoting effects of hypocretin-1 are attenuated in old rats (2011) (13)
- Parallel Arousal Pathways in the Lateral Hypothalamus (2018) (12)
- The 2-deoxyglucose neuroanatomical mapping technique (1981) (12)
- Cortical nNOS/NK1 Receptor Neurons are Regulated by Cholinergic Projections From the Basal Forebrain (2018) (12)
- Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques (2019) (11)
- HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy (1987) (11)
- Modulation of activity of the striatal dopaminergic system during the hibernation cycle (1987) (10)
- The Effects of Seasonal Photoperiods on Activity of Cotton Rats and Rice Rats (1979) (10)
- Animal Models of Narcolepsy and the Hypocretin/Orexin System: Past, Present, and Future. (2020) (9)
- Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs (1990) (9)
- Gene expression in the rat brain during prostaglandin D2 and adenosinergically‐induced sleep (2008) (9)
- Sleep-active cells in the cerebral cortex and their role in slow-wave activity (2011) (9)
- Cerebrospinal fluid monoamine levels in central hypersomnolence disorders. (2021) (8)
- Focal Increases of White Matter Glucose Utilization Produced by Electrical Stimulation of Rat Motor Cortex (1983) (8)
- Recovery from Sleep Deprivation (2004) (8)
- Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine (2018) (7)
- Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy (2019) (7)
- Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis (2019) (7)
- Shallow metabolic depression and human spaceflight: A feasible first step. (2020) (7)
- Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques☆ (2018) (6)
- Restriction fragment length polymorphism in canine narcolepsy (2004) (6)
- Monoamine and metabolite levels in the cerebrospinal fluid of hibernating and euthermic marmots (1992) (6)
- Brain benzodiazepine receptor characteristics in canine narcolepsy. (1986) (5)
- Interaction between the corticotropin-releasing-factor system and hypocretins: Components mediating the stress response (2004) (5)
- Cerebrospinal fluid monoamine levels in central disorders of hypersomnolence (2021) (5)
- Plasticity-Related Gene Expression During Eszopiclone-Induced Sleep (2017) (5)
- Anatomy of the Hypocretin System (2005) (5)
- H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms (2016) (5)
- Translational Models of Sleep and Sleep Disorders (2008) (4)
- HLA-DR2 and the Narcolepsy Syndrome: The Stanford Experience (1988) (4)
- Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture (2007) (4)
- The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice. (2022) (3)
- Pharmacology of Basimglurant ( RO 4917523 , RG 7090 ) , a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression s (2015) (3)
- Progressive activation of paratrigeminal nucleus during entrance to hibernation. (1988) (2)
- Automated Sleep Stage Scoring Using k-Nearest Neighbors Classifier (2020) (2)
- INHERITANCE OF BUNT AND LOOSE SMUT REACTION AND OF CERTAIN OTHER CHARACTERS IN KOTA × RED BOBS AND GARNET CROSSES (1933) (2)
- Sleepy dogs don't lie: a genetic disorder informative about sleep. (2001) (2)
- Autoradiographic patterns of hippocampal metabolism during induced hypothermia (1982) (2)
- Orexin receptors in GtoPdb v.2021.3. (2021) (2)
- MOLECULAR AND GENETIC ASPECTS OF SLEEP (1999) (2)
- Editorial overview: Neurobiology of sleep 2017 (2017) (2)
- Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain (2014) (1)
- Metabolic activation of the brachium conjunctivum during induced hypothermia (1983) (1)
- Neural Control of Mammalian Hibernation (1985) (1)
- Chapter 41 – Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects (2017) (1)
- Fisher and Dervin and the Ordinary Citizen: How Information Grounds and Sensemaking is Spurring Library and Information Science in the Areas of Design, User Behavior, and Library Amenities (2019) (1)
- The chromosomes of a long-isolated monotypic butterfly genus: Tellervo zoilus (Nymphalidae: Ithomiinae) in Australia (2009) (1)
- Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
- Peripheral vs. core body temperature as hypocretin/orexin neurons degenerate: Exercise mitigates increased heat loss (2022) (0)
- Resource Guide to Shamanism in the Northern California and the Western U.S. (2020) (0)
- Sleep Deprivation, Stimulant Medications, and Cognition: Novel pathways for stimulant development II: the hypocretin/orexin system (2012) (0)
- 0016 QEEG AND SLEEP/WAKE PHYSIOLOGY DISRUPTED IN NEUROLIGIN-3 KNOCKOUT RAT MODEL OF ASD (2017) (0)
- Sleep and aging: molecular approaches within a systems neurobiology context (2005) (0)
- Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 11, (4459-4464) DOI: 10.1073/pnas.0811126106) (2009) (0)
- Reciprocal interaction revisited (1986) (0)
- 0014 TRACE AMINE-ASSOCIATED RECEPTOR 1 REGULATES WAKEFULNESS, BEHAVIORAL ACTIVATION AND EEG SPECTRAL COMPOSITION (2017) (0)
- Palaces for the People’s Digital Literacy Skills: How to Invest in the Education of Citizens (2019) (0)
- Isolation and Identification of Specific Transcripts by Subtractive Hybridization (1997) (0)
- Afferent Control of the Hypocretin/Orexin Neurons (2011) (0)
- Application of the [14C]deoxyglucose technique to the study of hibernation and thermoregulation☆ (1981) (0)
- 0100 LATERAL HYPOTHALAMIC HYPOCRETIN AND NON-HYPOCRETIN NEURONS ACTIVATE PARALLEL AROUSAL PATHWAYS (2017) (0)
- Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity. (2023) (0)
- Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology. (2016) (0)
- The 2-deoxyglucose neu roan atom ical m appin g technique (1981) (0)
- ALMOREXANT EFFECTS ON SLEEP AND CATAPLEXY IN NARCOLEPSY MODEL (2013) (0)
- Narcolepsy and Hypersomnia (2006) (0)
- The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice (2021) (0)
- Corrections (1967) (0)
- Immediate Early Gene Expression in Brain Across the Hibernation Cycle (2019) (0)
- Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice (2022) (0)
- 0122 HYPOCRETIN AFFECTS THE EXCITABILITY OF CORTICAL NNOS/NK1 NEURONS (2017) (0)
- Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance (2010) (0)
- Neurobiological Correlates of Sleep Homeostasis (2001) (0)
- A population study of Euptychia hermes in northern Florida (1972) (0)
- Narcolepsy: a neurodegenerative disease of the hypocretin/orexin system? (2000) (0)
- Inheritance of resistance to smut and of some plant characters in wheat (0)
- cDNA array studies of natural and pharmacologically induced sleep (2004) (0)
- INFLUENCE OF SEROTONERGIC INPUTS TO OREXIN/HYPOCRETIN NEURONS Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness (2013) (0)
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Thomas Kilduff is affiliated with the following schools:
