Thomas Lengauer
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German computer scientist and mathematician
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Thomas Lengauermathematics Degrees
Mathematics
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Computer Science Mathematics
Thomas Lengauer's Degrees
- PhD Mathematics University of Passau
Why Is Thomas Lengauer Influential?
(Suggest an Edit or Addition)According to Wikipedia, Thomas Lengauer is a German computer scientist and computational biologist. Education Lengauer studied Mathematics at the Free University of Berlin, earning his Diploma in 1975 and a Dr. rer. nat. in 1976. Lengauer later gained an MSc and a PhD in computer science, both from Stanford University. He received his habilitation degree in computer science at Saarland University in 1984.
Thomas Lengauer's Published Works
Published Works
- ROCR: visualizing classifier performance in R (2005) (2754)
- A fast flexible docking method using an incremental construction algorithm. (1996) (2433)
- A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 (2007) (1868)
- Improved scoring of functional groups from gene expression data by decorrelating GO graph structure (2006) (1749)
- Computing topological parameters of biological networks (2008) (1448)
- Combinatorial algorithms for integrated circuit layout (1990) (1158)
- Permutation importance: a corrected feature importance measure (2010) (1065)
- Evaluation of the FLEXX incremental construction algorithm for protein–ligand docking (1999) (835)
- A fast algorithm for finding dominators in a flowgraph (1979) (722)
- A new measure for functional similarity of gene products based on Gene Ontology (2006) (679)
- Computational methods for biomolecular docking. (1996) (633)
- BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing (2005) (596)
- Comprehensive Analysis of DNA Methylation Data with RnBeads (2014) (546)
- Genetic variation in DLG5 is associated with inflammatory bowel disease (2004) (499)
- Engineering Support Vector Machine Kerneis That Recognize Translation Initialion Sites (2000) (477)
- Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. (2011) (467)
- FlexE: efficient molecular docking considering protein structure variations. (2001) (441)
- Sarcoidosis is associated with a truncating splice site mutation in BTNL2 (2005) (441)
- Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types (2011) (381)
- Co-clustering of biological networks and gene expression data (2002) (379)
- The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
- A DNA methylation fingerprint of 1628 human samples. (2011) (359)
- Classification with correlated features: unreliability of feature ranking and solutions (2011) (340)
- Bioinformatics prediction of HIV coreceptor usage (2007) (322)
- BLUEPRINT to decode the epigenetic signature written in blood (2012) (320)
- AltAnalyze and DomainGraph: analyzing and visualizing exon expression data (2010) (279)
- Mutations in the NB-ARC Domain of I-2 That Impair ATP Hydrolysis Cause Autoactivation1[OA] (2006) (275)
- Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype (2002) (259)
- Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes (2003) (256)
- Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005) (236)
- CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure (2006) (227)
- The implications of alternative splicing in the ENCODE protein complement (2007) (227)
- NOXclass: prediction of protein-protein interaction types (2006) (208)
- Making sense of big data in health research: Towards an EU action plan (2016) (205)
- CpG Island Mapping by Epigenome Prediction (2007) (205)
- FLEXS: a method for fast flexible ligand superposition. (1998) (204)
- From hype to reality: data science enabling personalized medicine (2018) (203)
- Multi-task learning for HIV therapy screening (2008) (202)
- Placement of medium-sized molecular fragments into active sites of proteins (1996) (200)
- The particle concept: placing discrete water molecules during protein‐ligand docking predictions (1999) (186)
- Computational epigenetics (2008) (186)
- DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation (2016) (183)
- Predicting HIV Coreceptor Usage on the Basis of Genetic and Clinical Covariates (2007) (181)
- Multiple automatic base selection: Protein–ligand docking based on incremental construction without manual intervention (1997) (179)
- Pathway analysis in metabolic databases via differetial metabolic display (DMD) (2000) (169)
- RnBeads 2.0: comprehensive analysis of DNA methylation data (2019) (164)
- Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. (2016) (159)
- Flexible docking under pharmacophore type constraints (2002) (152)
- An integrative approach to gain insights into the cellular function of human ataxin-2. (2005) (149)
- Calculating the Statistical Significance of Changes in Pathway Activity From Gene Expression Data (2004) (143)
- Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping (2008) (143)
- Managing drug resistance in cancer: lessons from HIV therapy (2012) (143)
- Learning multiple evolutionary pathways from cross-sectional data (2004) (142)
- Novel technologies for virtual screening. (2004) (137)
- An Algorithm for Finding Maximal Common Subtopologies in a Set of Protein Structures (1996) (137)
- Structural and functional analysis of ataxin-2 and ataxin-3. (2004) (135)
- Improving disease gene prioritization using the semantic similarity of Gene Ontology terms (2010) (134)
- Centralization: a new method for the normalization of gene expression data (2001) (130)
- Recco: recombination analysis using cost optimization (2006) (127)
- Analysis of Gene Expression Data with Pathway Scores (2000) (125)
- BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing (2011) (123)
- Time-space trade-offs in a pebble game (1977) (121)
- Computational methods for the design of effective therapies against drug resistant HIV strains (2005) (111)
- The pebbling problem is complete in polynomial space (1979) (107)
- Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. (2005) (106)
- Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. (2005) (103)
- Structural Descriptors of gp120 V3 Loop for the Prediction of HIV-1 Coreceptor Usage (2007) (103)
- Survey on the PABC recognition motif PAM2. (2004) (98)
- Estimating HIV evolutionary pathways and the genetic barrier to drug resistance. (2005) (94)
- Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development (2018) (91)
- Information Technologies in Biomedicine (2008) (91)
- Deep Sequencing Reveals Mutagenic Effects of Ribavirin during Monotherapy of Hepatitis C Virus Genotype 1-Infected Patients (2013) (91)
- Geno2pheno[HCV] – A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents (2016) (89)
- Mtreemix: a software package for learning and using mixture models of mutagenetic trees (2005) (89)
- Docking of hydrophobic ligands with interaction-based matching algorithms (1999) (89)
- EpiExplorer: live exploration and global analysis of large epigenomic datasets (2012) (88)
- Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction (2016) (86)
- Novel Sm‐like proteins with long C‐terminal tails and associated methyltransferases (2004) (84)
- Microarrays: how many do you need? (2002) (81)
- Ensemble Methods for Classification in Cheminformatics (2004) (81)
- Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors (2006) (81)
- Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus (2008) (80)
- Two-stage method for protein-ligand docking. (1999) (79)
- Simple consensus procedures are effective and sufficient in secondary structure prediction. (2003) (77)
- Computational analysis of human protein interaction networks (2007) (77)
- Tenofovir Resistance and Resensitization (2003) (76)
- Automatic Generation of Complementary Descriptors with Molecular Graph Networks (2005) (75)
- Local protein structure prediction using discriminative models (2006) (75)
- The HIN domain of IFI-200 proteins consists of two OB folds. (2005) (75)
- The Correlation between the Complexities of the Nonhierarchical and Hierarchical Versions of Graph Problems (1987) (74)
- A new CARD15 mutation in Blau syndrome (2005) (73)
- Selecting anti-HIV therapies based on a variety of genomic and clinical factors (2008) (73)
- Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. (2005) (71)
- Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues (2012) (71)
- Epigenetic dynamics of monocyte-to-macrophage differentiation (2016) (70)
- Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors (2007) (70)
- DynaPred: A structure and sequence based method for the prediction of MHC class I binding peptide sequences and conformations (2006) (69)
- Decision tree-based formation of consensus protein secondary structure prediction (1999) (68)
- Comparison of Classifier Fusion Methods for Predicting Response to Anti HIV-1 Therapy (2008) (65)
- Identification of PatL1, a human homolog to yeast P body component Pat1. (2007) (65)
- Estimating cancer survival and clinical outcome based on genetic tumor progression scores (2005) (64)
- A simulated annealing approach to the nesting problem in the textile manufacturing industry (1995) (63)
- Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair (2006) (62)
- Hierarchical planarity testing algorithms (1989) (61)
- Upper and Lower Bounds on the Complexity of the Min-Cut Linear Arrangement Problem on Trees (1982) (61)
- Predicting the response to combination antiretroviral therapy: retrospective validation of geno2pheno-THEO on a large clinical database. (2009) (60)
- Improved Prediction of Response to Antiretroviral Combination Therapy using the Genetic Barrier to Drug Resistance (2006) (60)
- EpiGRAPH: user-friendly software for statistical analysis and prediction of (epi)genomic data (2009) (60)
- DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets (2016) (60)
- Methods for optimizing antiviral combination therapies (2003) (59)
- Efficient Solution of Connectivity Problems on Hierarchically Defined Graphs (1988) (59)
- Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. (2005) (58)
- A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains (2018) (58)
- Innovations: Bioinformatics-assisted anti-HIV therapy (2006) (58)
- Improved cyclodextrin-based receptors for camptothecin by inverse virtual screening. (2007) (58)
- Structural localization of disease‐associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2 (2003) (57)
- Time-efficient flexible superposition of medium-sized molecules (1997) (57)
- IRECS: A new algorithm for the selection of most probable ensembles of side‐chain conformations in protein models (2007) (56)
- CASP2 experiences with docking flexible ligands using FLEXX (1997) (56)
- Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology (1998) (56)
- Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer (2007) (56)
- VLSI Theory (1991) (55)
- Moment invariants as shape recognition technique for comparing protein binding sites (2007) (53)
- Geno2pheno: Interpreting Genotypic HIV Drug Resistance Tests (2001) (53)
- Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment. (2005) (53)
- Algorithmic Aspects of One-Dimensional Layout Compaction (1987) (51)
- Bioinformatics : from genomes to therapies (2007) (50)
- Protein threading by recursive dynamic programming. (1999) (50)
- Efficient Analysis of Graph Properties on Context-free Graph Languages (Extended Abstract) (1988) (49)
- Predicting Response to Antiretroviral Treatment by Machine Learning: The EuResist Project (2012) (49)
- Arby: automatic protein structure prediction using profile-profile alignment and confidence measures (2004) (49)
- Time-Efficient Docking of Flexible Ligands into Active Sites of Proteins (1995) (49)
- Prediction of response to antiretroviral therapy by human experts and by the EuResist data‐driven expert system (the EVE study) (2010) (48)
- Functional Evaluation of Domain-Domain Interactions and Human Protein Interaction Networks (2007) (48)
- A Fully Computational Model for Predicting Percutaneous Drug Absorption (2006) (46)
- Predicting MHC class I epitopes in large datasets (2010) (46)
- Amino Acid Variations in Hepatitis C Virus P7 and Sensitivity to Antiviral Combination Therapy with Amantadine in Chronic Hepatitis C (2005) (46)
- Black-white pebbles and graph separation (1981) (45)
- Application of oncogenetic trees mixtures as a biostatistical model of the clonal cytogenetic evolution of meningiomas (2007) (43)
- The complexity of compacting hierarchically specified layouts of integrated circuits (1982) (42)
- Improved prediction of HIV‐1 coreceptor usage with sequence information from the second hypervariable loop of gp120. (2010) (41)
- Genotypic coreceptor analysis. (2007) (40)
- A Discrete Algorithm for Crystal Structure Prediction of Organic Molecules (1997) (40)
- ProML - the Protein Markup Language for specification of protein sequences, structures and families (2002) (39)
- Characterization of Novel HIV Drug Resistance Mutations Using Clustering, Multidimensional Scaling and SVM-Based Feature Ranking (2005) (39)
- The nesting problem in the leather manufacturing industry (1995) (38)
- Efficient Algorithms for Finding Minimum Spanning Forests of Hierarchically Defined Graphs (1987) (38)
- Learning Mixtures of Localized Rules by Maximizing the Area Under the ROC Curve (2004) (38)
- Structural modeling of ataxin‐3 reveals distant homology to adaptins (2002) (37)
- Structural and functional comparison of the non-structural protein 4B in flaviviridae. (2007) (37)
- The efficient solution of integer programs for hierarchical global routing (1991) (36)
- Processing of Hierarchically Defined Graphs and Graph Families (1992) (36)
- Sensitive Detection of Viral Transcripts in Human Tumor Transcriptomes (2013) (35)
- Alignment of Non-Covalent Interactions at Protein-Protein Interfaces (2008) (35)
- Multiple-ligand-based virtual screening: methods and applications of the MTree approach. (2005) (34)
- Docking and scoring with alternative side‐chain conformations (2009) (34)
- The Space Complexity of Pebble Games on Trees (1980) (33)
- A robust framework for hierarchical floorplanning with integrated global wiring (1990) (33)
- RigFit: A new approach to superimposing ligand molecules (1998) (32)
- Improving HIV coreceptor usage prediction in the clinic using hints from next-generation sequencing data (2012) (32)
- Analysis of Physicochemical and Structural Properties Determining HIV-1 Coreceptor Usage (2013) (32)
- Confirmation of human protein interaction data by human expression data (2005) (31)
- Upper and lower bounds on time-space tradeoffs (1979) (31)
- Bioinformatics ‐ From Genomes to Drugs (2001) (31)
- The HILL system : a design environment for the hierarchical specification, compaction, and simulation of integrated circuit layouts (1983) (31)
- Exploiting Hierarchy in VLSI Design (1986) (30)
- Quantitative comparison of within-sample heterogeneity scores for DNA methylation data (2020) (30)
- Pyranose Oxidase Identified as A Member of the GMC Oxidoreductase Family (2003) (30)
- Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART. (2006) (30)
- Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients (2011) (30)
- geno2pheno[ngs-freq]: a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data (2018) (30)
- Unstructured Path Problems and the Making of Semirings (Preliminary Version) (1991) (29)
- Epidemiology of Transmitted Drug Resistance in Chronically HIV-Infected Patients in Germany: The RESINA Study 2001–2009 (2012) (29)
- On the Applicability of Elastic Network Normal Modes in Small-Molecule Docking (2012) (29)
- On the Solution of Inequality Systems Relevant to IC-Layout (1984) (28)
- GOTax: investigating biological processes and biochemical activities along the taxonomic tree (2007) (28)
- Confidence measures for protein fold recognition (2002) (28)
- Clinical significance of in vitro replication-enhancing mutations of the hepatitis C virus (HCV) replicon in patients with chronic HCV infection. (2005) (28)
- MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays (2009) (27)
- Decomposing protein networks into domain-domain interactions (2005) (26)
- Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis (2011) (26)
- Failure of Dolutegravir First-Line ART with Selection of Virus Carrying R263K and G118R. (2019) (26)
- Fully Automated Flexible Docking of Ligands into Flexible Synthetic Receptors Using Forward and Inverse Docking Strategies (2006) (26)
- Computing closely matching upper and lower bounds on textile nesting problems (1998) (26)
- Modelling binding between CCR5 and CXCR4 receptors and their ligands suggests the surface electrostatic potential of the co-receptor to be a key player in the HIV-1 tropism (2013) (26)
- Enthalpy-Entropy Compensation upon Molecular Conformational Changes. (2015) (25)
- Full genome ultra‐deep pyrosequencing associates G‐to‐A hypermutation of the hepatitis B virus genome with the natural progression of hepatitis B (2013) (25)
- Linear algorithms for optimizing the layout of dynamic CMOS cells (1988) (25)
- Mutations in Gp41 are Correlated with Coreceptor Tropism but Do Not Improve Prediction Methods Substantially (2011) (25)
- MicroRNA Transcription Start Site Prediction with Multi-objective Feature Selection (2012) (25)
- Unique and assay specific features of NOMe-, ATAC- and DNase I-seq data (2019) (25)
- Preserving Charge and Oxidation State of Au(III) Ions in an Agent-Functionalized Nanocrystal Model System (2011) (24)
- Algorithms—ESA '93 (1993) (24)
- Algorithmic research problems in molecular bioinformatics (1993) (24)
- Genotyping hepatitis B virus dual infections using population-based sequence data. (2012) (24)
- BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives (2014) (23)
- Proceedings of the Fifth Annual International Conference on Computational Biology, RECOMB 2001, Montréal, Québec, Canada, April 22-25, 2001 (2001) (23)
- Protein Structure Prediction Methods for Drug Design (2000) (23)
- On the Complexity of VLSI Computations (1981) (23)
- Data and text mining ROCR : visualizing classifier performance in R (2005) (22)
- A simple iterative approach to parameter optimization (2000) (22)
- Proviral DNA as a Target for HIV-1 Resistance Analysis (2015) (22)
- Personalized HIV therapy to control drug resistance. (2014) (22)
- Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence (2003) (21)
- Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV (2006) (20)
- Detection of Distant Structural Similarities in a Set of Proteins Using a Fast Graph-Based Method (1997) (20)
- Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination (2007) (20)
- Geno2pheno[454]: A Web Server for the Prediction of HIV-1 Coreceptor Usage from Next-Generation Sequencing Data (2012) (20)
- Efficient Algorithms for the Constraint Generation for Integrated Circuit Layout Compaction (1983) (20)
- A recursive algorithm for efficient combinatorial library docking (2000) (20)
- Selective Pressures of HLA Genotypes and Antiviral Therapy on Human Immunodeficiency Virus Type 1 Sequence Mutation at a Population Level (2007) (19)
- Dealing with sparse data in predicting outcomes of HIV combination therapies (2010) (19)
- An integrative approach for predicting interactions of protein regions (2008) (19)
- Efficient Algorithms for Path Problems with Gernal Cost Citeria (1991) (19)
- DASMI: exchanging, annotating and assessing molecular interaction data (2009) (19)
- Prediction of HIV-1 coreceptor usage (tropism) by sequence analysis using a genotypic approach. (2011) (18)
- Peptidomimetic escape mechanisms arise via genetic diversity in the ligand-binding site of the hepatitis C virus NS3/4A serine protease. (2012) (18)
- Improving the quality of protein structure models by selecting from alignment alternatives (2006) (18)
- Efficient decision procedures for graph properties on context-free graph languages (1993) (18)
- Fast and numerically stable parametric alignment of biosequences (1997) (18)
- Positive selection of HIV host factors and the evolution of lentivirus genes (2010) (17)
- Correlation of amino acid variations within nonstructural 4B protein with initial viral kinetics during interferon‐alpha‐based therapy in HCV‐1b‐infected patients (2007) (17)
- Local Function Conservation in Sequence and Structure Space (2008) (17)
- Operations Research and Statistics (1990) (17)
- Using drug exposure for predicting drug resistance – A data-driven genotypic interpretation tool (2017) (17)
- Modeling amorphousSi3B3N7: Structure and elastic properties (2004) (16)
- Improving fold recognition of protein threading by experimental distance constraints (2001) (16)
- Advantages of predicted phenotypes and statistical learning models in inferring virological response to antiretroviral therapy from HIV genotype (2008) (16)
- Robust and accurate hierarchical floorplanning with integrated global wiring (1993) (16)
- Learning from Past Treatments and Their Outcome Improves Prediction of In Vivo Response to Anti-HIV Therapy (2011) (16)
- Placement, Assignment, and Floorplanning (1990) (16)
- Metabolic screening of Saccharomyces cerevisiae single knockout strains reveals unexpected mobilization of metabolic potential (2006) (16)
- Rtreemix: an R package for estimating evolutionary pathways and genetic progression scores (2008) (16)
- Structural and functional analysis of a novel mutation of CYP21B in a heterozygote carrier of 21-hydroxylase deficiency (2005) (16)
- V3 Loop Sequence Space Analysis Suggests Different Evolutionary Patterns of CCR5- and CXCR4-Tropic HIV (2009) (15)
- Inferring Viral Tropism from Genotype with Massively Parallel Sequencing: Qualitative and Quantitative Analysis (2008) (15)
- Automated clustering of ensembles of alternative models in protein structure databases. (2004) (15)
- Association of HCV-related mixed cryoglobulinemia with specific mutational pattern of the HCV E2 protein and CD81 expression on peripheral B lymphocytes. (2004) (15)
- POEM: Parameter Optimization Using Ensemble Methods: Application to Target Specific Scoring Functions (2005) (15)
- HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection. (2010) (15)
- An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data (2012) (15)
- Dimerization of the hepatitis C virus nonstructural protein 4B depends on the integrity of an aminoterminal basic leucine zipper (2010) (15)
- Dynamics of NRTI resistance mutations during therapy interruption. (2009) (14)
- Supplemental Information Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS 5 A Is Essential for Integrity of the Membranous Replication Compartment (2010) (14)
- Sequence and Structure Analysis of Distantly-Related Viruses Reveals Extensive Gene Transfer between Viruses and Hosts and among Viruses (2015) (14)
- Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz (2020) (14)
- Model Selection for Mixtures of Mutagenetic Trees (2006) (14)
- Prediction of crystal structures of organic molecules (1999) (14)
- Web-based analysis of (Epi-) genome data using EpiGRAPH and Galaxy. (2010) (14)
- HIV prevalence and route of transmission in Turkish immigrants living in North-Rhine Westphalia, Germany (2011) (14)
- HIV-1 mutational pathways under multidrug therapy (2011) (14)
- Coronavirus-Pandemie – Die Krise nachhaltig überwinden (2020) (14)
- Association Between HIV-1 Coreceptor Usage and Resistance to Broadly Neutralizing Antibodies (2014) (13)
- Recursive Dynamic Programming for Adaptive Sequence and Structure Alignment (1995) (13)
- Linear Algorithms For Two CMOS Layout Problems (1986) (13)
- Identification of mammalian orthologs associates PYPAF5 with distinct functional roles (2003) (13)
- A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support (2016) (13)
- Visualizing the Performance of Scoring Classifiers [R package ROCR version 1.0-11] (2020) (13)
- Stability analysis of mixtures of mutagenetic trees (2008) (12)
- Strategiekonzept "Molekulare Bioinformatik" (2008) (12)
- Erratum to: Making sense of big data in health research: towards an EU action plan (2016) (12)
- Efficient automatic part nesting on irregular and inhomogeneous surfaces (1993) (12)
- Flexible Docking of Ligands into Synthetic Receptors Using a Two-Sided Incremental Construction Algorithm (2006) (11)
- ISCB’s initial reaction to New England Journal of Medicine editorial on data sharing (2016) (11)
- A method for finding consensus breakpoints in the cancer genome from copy number data (2013) (11)
- Upper and lower bounds on time-space tradeoffs in a pebble game (1979) (11)
- The Helmholtz Network for Bioinformatics: an integrative web portal for bioinformatics resources (2004) (11)
- Integer Program formulations of Global Routing and Placement Problems (1993) (11)
- Relative Principal Components Analysis: Application to Analyzing Biomolecular Conformational Changes (2018) (10)
- Computational Biology at the Beginning of the Post-genomic Era (2001) (10)
- Efficient computation of root mean square deviations under rigid transformations (2014) (10)
- HERO: Hierarchical EMC-constrained routing (1992) (10)
- DNA Methylation Patterns Facilitate the Identification of MicroRNA Transcription Start Sites: A Brain-Specific Study (2013) (10)
- APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1 (2011) (10)
- The Role of Conformational Changes in Molecular Recognition. (2016) (10)
- ISCB’s Initial Reaction to The New England Journal of Medicine Editorial on Data Sharing (2016) (10)
- Integrating expression data with domain interaction networks (2008) (10)
- Parameters Influencing Baseline HIV-1 Genotypic Tropism Testing Related to Clinical Outcome in Patients on Maraviroc (2015) (10)
- Soluble immune markers in the different phases of chronic hepatitis B virus infection (2019) (10)
- Derivation of a scoring function for crystal structure prediction. (2001) (10)
- Rhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2 (2021) (9)
- Protein function from sequence and structure data. (2003) (9)
- Performance of Genotypic Coreceptor Measurement Using Geno2pheno[coreceptor] in B- and non-B HIV Subtypes in a Large Cohort of Therapy-experienced Patients in Germany (2009) (9)
- History-alignment models for bias-aware prediction of virological response to HIV combination therapy (2012) (9)
- CpG island methylation in human lymphocytes is highly correlated with DNA sequence patterns, repeat frequencies and predicted DNA structure (2005) (9)
- Geno2pheno is predictive of short-term virological response (2002) (9)
- Computing Upper and Lower Bounds on Textile Nesting Problems (1996) (9)
- Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C. (2009) (9)
- Automated Layout Generation and Wiring Area Estimation for 3D Electronic Modules (2001) (9)
- Hierarchical Bayes Model for Predicting Effectiveness of HIV Combination Therapies (2012) (9)
- Inferring Short-Range Linkage Information from Sequencing Chromatograms (2013) (9)
- Bioinformatical Assistance of Selecting Anti-HIV Therapies: Where Do We Stand? (2012) (9)
- Conformational analysis of alternative protein structures (2007) (9)
- A general concept for consistent documentation of computational analyses (2015) (9)
- Computational recognition of potassium channel sequences (2006) (9)
- Risk Factors Associated with Older Age in Treatment-Naive HIV-Positive Patients (2012) (9)
- Multiple molecular superpositioning as an effective tool for virtual database screening (2000) (8)
- Predicting protein structure classes from function predictions (2004) (8)
- Centralization: A biologically sensible method for the normalization of gene expression data (2001) (8)
- Hierarchical Planary Testing Algorithms (1986) (8)
- Robust methods for EMC-driven routing (1994) (8)
- Crystal Structure Prediction based on Statistical Potentials (1998) (8)
- Parallel 'Go with the winners' algorithms in the LogP model (1997) (8)
- Software tool for automated processing of 13C labeling data from mass spectrometric spectra. (2003) (8)
- Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey (2019) (8)
- Geno2pheno[coreceptor]: a Tool for Predicting Coreceptor Usage from Genotype and for Monitoring Coreceptor-associated Sequence Alterations (2005) (7)
- Four results on the complexity of VLSI computations (1983) (7)
- geno 2 pheno [ ngs-freq ] : a genotypic interpretation system for identifying viral drug resistance using next-generation sequencing data (2018) (7)
- Corrigendum: Sarcoidosis is associated with a truncating splice site mutation in the gene BTNL2 (2005) (7)
- Protein-protein interactions: analysis and prediction (2009) (7)
- DeepBlueR: large-scale epigenomic analysis in R (2017) (7)
- Fifteen years of Env C2V3C3 evolution in six individuals infected clonally with human immunodeficiency virus type 1 (2007) (7)
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- Stellenwert der Bioinformatik für die personalisierte Medizin (2013) (0)
- Hierarchische Darstellung geometrischer Objekte und ihre algorithmische Bedeutung (1986) (0)
- Proceedings of the 5th Annual Conference on Research in Computational Molecular Biology (RECOMB2001) (2001) (0)
- Erratum to: Making sense of big data in health research: towards an EU action plan (2016) (0)
- Data Curation of the GISAID EpiFlu Influenza Database (2012) (0)
- Molecular Bioinformatics (Dagstuhl Seminar 9528) (1995) (0)
- EDITORIAL: Informatik in den Biowissenschaften (1996) (0)
- 348 HOMODIMERIZATION OF THE HEPATITIS C VIRUS NON-STRUCTURAL 4B PROTEIN REQUIRES AN INTACT BASIC LEUCINE ZIPPER (2009) (0)
- Structure and network analysis of non-covalent residue interactions for T54 (2011) (0)
- An Exhaustive Methode for CpG Island Annotation (2009) (0)
- Bioinformatikmethoden für die Optimierung antiviraler Kombinationstherapien (2003) (0)
- Computational Biology - Algorithms and More (2000) (0)
- Geno2pheno: Genotypic HIV Drug Resistance Tests (2001) (0)
- Eleventh International Congress on Drug Therapy in HIV Infection (2012) (0)
- Eleventh International Congress on Drug Therapy in HIV Infection (2012) (0)
- Ancestral Germline Methylation Reconstruction of Young Repeats (2010) (0)
- Corrigendum to: Family-joining: A fast distance-based method for constructing generally labeled trees (2020) (0)
- 971 MOLECULAR MECHANISMS OF CROSS-RESISTANCE IN PEPTIDOMIMETIC PROTEASE INHIBITORS FOR STAT-C (2009) (0)
- Optimisation of baseline genotypic testing for safe and efficient maraviroc administration (2012) (0)
- Analysis of structural conservation in protein-protein binding sites and functional implications (2007) (0)
- Long-term results of peripheral nerve repair: A comparison of nerve anastomosis with ethyl-cyanoacrylate and epineural sutures (2010) (0)
- BIOINFORMATICS Improving HIV coreceptor usage prediction in the clinic using hints from next-generation sequencing data (2012) (0)
- 616 EFFECT OF RIBAVIRIN ON THE FREQUENCY OF RNASE L CLEAVAGE SITES WITHIN THE HEPATITIS C VIRAL GENOME (2009) (0)
- FlexR - Predicting the structure of host-guest complexes (2004) (0)
- Special RECOMB 2002 Issue (2004) (0)
- NS3-4A protease domain of PDB structure with co-crystallized ligand CPX (yellow) 32 and a second ligand, SCH 446211 (light blue), taken from the superimposed PDB structure 30 (2011) (0)
- Improved HIV-1 Drug-exposure Reconstruction with Linear Support Vector Machines (2014) (0)
- A probabilistic algorithm for matching protein structures - and its application to detecting functionally relevant patterns (2010) (0)
- Dissecting DNA Methylation in Human Aging (2016) (0)
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