A. Thomas Look

Q: What Schools Are Affiliated With A. Thomas Look

A. Thomas Look is affiliated with the following schools: University of Oxford, University of Michigan, University of Tennessee, Massachusetts Institute of Technology, University of Tennessee Health Science Center, Harvard University

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A. Thomas Look

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#1162

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#1475

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#24

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#32

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A. Thomas Look

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#1797

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#2242

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#56

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A. Thomas Look's Degrees

Doctorate Medicine Harvard University

Why Is A. Thomas Look Influential?

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According to Wikipedia, A. Thomas Look is Professor of Pediatrics at Harvard Medical School and Vice-Chair for Research, Pediatric Oncology, Dana–Farber Cancer Institute. He is a pioneer in the use of zebrafish in cancer research and made major contributions to the understanding of leukemia and neuroblastoma biology and pathogenesis.

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A. Thomas Look's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia (2004) (2737)
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1 (1985) (1371)
Oncogenic transcription factors in the human acute leukemias. (1997) (1281)
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish (2009) (1190)
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. (2002) (1105)
Human aminopeptidase N is a receptor for human coronavirus 229E (1992) (864)
Acute lymphoblastic leukaemia (2008) (842)
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth (2006) (840)
Activating mutations in ALK provide a therapeutic target in neuroblastoma (2008) (830)
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN (2000) (811)
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors (2007) (675)
BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma (2005) (651)
Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. (1991) (587)
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. (2005) (576)
The use of zebrafish to understand immunity. (2004) (572)
An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element (2014) (570)
Myc-Induced T Cell Leukemia in Transgenic Zebrafish (2003) (524)
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. (1998) (511)
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish (2006) (489)
Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. (1984) (489)
Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. (2005) (483)
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia (2006) (451)
Molecular genetics of acute lymphoblastic leukemia. (2005) (437)
Myelopoiesis in the zebrafish, Danio rerio. (2001) (435)
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. (2009) (433)
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia (2004) (432)
Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma (2005) (418)
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers (2007) (405)
Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy (1991) (389)
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. (1990) (387)
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. (2004) (383)
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. (1993) (381)
Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. (2005) (379)
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. (2005) (377)
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. (1992) (373)
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. (2003) (350)
Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. (1986) (350)
New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia (1984) (350)
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. (2008) (330)
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (1996) (311)
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo (2009) (311)
Chromosome 1p and 11q deletions and outcome in neuroblastoma. (2005) (299)
The requirement for cyclin D function in tumor maintenance. (2012) (292)
Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. (2012) (290)
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (1992) (277)
Bone-marrow transplantation in a patient with sickle-cell anemia. (1984) (276)
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (2012) (276)
Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. (1997) (270)
Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3 (2008) (269)
Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. (1985) (265)
A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. (1995) (260)
Activating Notch1 mutations in mouse models of T-ALL. (2005) (247)
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism (2015) (241)
Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. (2010) (239)
Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia (2005) (239)
Amplification of the gli gene in childhood sarcomas. (1989) (231)
Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors (2001) (224)
The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. (1991) (223)
Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1) (1994) (220)
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study (1990) (214)
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (213)
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. (1999) (212)
Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! (1993) (211)
Notch signaling: switching an oncogene to a tumor suppressor. (2014) (210)
Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study. (1992) (207)
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy (2009) (204)
Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation (2007) (199)
Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19). (1990) (194)
Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. (2007) (188)
Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. (2006) (182)
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. (2002) (179)
Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. (1992) (175)
Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: the pediatric oncology group experience--a pediatric oncology group study. (1998) (173)
Significance of chromosome 1p loss of heterozygosity in neuroblastoma. (1995) (172)
Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. (2004) (172)
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. (2014) (170)
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. (1997) (170)
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells (2012) (169)
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia (2012) (167)
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. (2011) (167)
Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia (2004) (165)
Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma. (1993) (160)
Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia. (1986) (158)
Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia. (1982) (157)
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. (2010) (155)
KPT‐330 inhibitor of CRM1 (XPO1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of T‐cell acute lymphoblastic leukaemia and acute myeloid leukaemia (2013) (155)
Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study. (1992) (155)
The pu.1 promoter drives myeloid gene expression in zebrafish. (2004) (154)
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. (2007) (151)
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes (1988) (150)
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. (2012) (150)
Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. (2000) (150)
Characterization of human homologs of the Drosophila seven in absentia (sina) gene. (1997) (149)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (148)
Hematopoietic gene expression profile in zebrafish kidney marrow. (2004) (144)
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. (2009) (144)
Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. (1997) (143)
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival (2005) (141)
Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. A Pediatric Oncology Group (POG) study (1999) (141)
Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. (2005) (140)
Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. (2004) (139)
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. (2007) (138)
Gene expression profiling in T-cell acute lymphoblastic leukemia. (2003) (138)
Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. (1987) (137)
MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. (2018) (134)
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. (2012) (131)
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. (1993) (131)
Oncogene amplification in pediatric brain tumors. (1990) (130)
Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor (1996) (128)
Mechanisms of transcription factor deregulation in lymphoid cell transformation (2007) (128)
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. (2014) (127)
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1 (2007) (127)
Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group Study. (1997) (125)
CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors (2009) (125)
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. (2003) (125)
Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays (2007) (125)
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. (2013) (125)
Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. (1984) (124)
Cyclin C is a haploinsufficient tumour suppressor (2014) (124)
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. (2010) (120)
Cell surface expression of v-fms-coded glycoproteins is required for transformation (1984) (119)
Nathan and Oski's hematology and oncology of infancy and childhood / (2015) (118)
Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. (2010) (117)
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma (1994) (116)
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL (2011) (116)
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. (2004) (115)
Heat‐shock induction of T‐cell lymphoma/leukaemia in conditional Cre/lox‐regulated transgenic zebrafish (2007) (115)
NOTCH and PI3K-AKT pathways intertwined. (2007) (114)
Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia. (1990) (113)
Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer. (1994) (112)
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (111)
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. (2005) (106)
Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study (2015) (105)
Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study. (1997) (105)
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia (2011) (105)
SNP array analysis in hematologic malignancies: avoiding false discoveries. (2010) (103)
Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. (2007) (101)
New recurring chromosomal translocations in childhood acute lymphoblastic leukemia. (1991) (100)
Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia. (1993) (100)
Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia. (1989) (99)
Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study. (1990) (99)
Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics* (2012) (99)
Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study. (2000) (98)
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (1999) (97)
The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line (1986) (96)
In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury1 (2008) (96)
Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish (2011) (95)
Alu elements mediate MYB gene tandem duplication in human T-ALL (2007) (94)
The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells (2018) (93)
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development (2012) (93)
Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma (1999) (92)
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. (2018) (92)
Identification and characterization of neogenin, a DCC-related gene (1997) (92)
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. (2010) (91)
Residential Pesticide Exposure and Neuroblastoma (2001) (91)
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. (1995) (91)
Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish (2004) (90)
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. (2010) (90)
Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study. (1995) (90)
Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor. (1986) (88)
NOTCH1-induced T-cell leukemia in transgenic zebrafish (2007) (88)
Accurate Detection of Uniparental Disomy and Microdeletions by SNP Array Analysis in Myelodysplastic Syndromes with Normal Cytogenetics (2009) (85)
Near-haploid acute lymphoblastic leukemia: a unique subgroup with a poor prognosis? (1981) (84)
Two Distinct Interleukin-3-Mediated Signal Pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, Regulate the Survival of Murine Pro-B Lymphocytes (1999) (83)
Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma. (1991) (83)
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification (2010) (82)
Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study. (2001) (82)
Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy. (2005) (81)
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish (2016) (80)
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. (2012) (80)
Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish. (2010) (80)
Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features (1992) (79)
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study. (1990) (78)
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells (2016) (78)
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. (2008) (77)
Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study. (1998) (76)
Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (1996) (74)
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. (2005) (74)
Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish (2008) (74)
NUP98‐HOXA9‐transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis (2011) (73)
Allogeneic bone marrow transplantation in a program of intensive sequential chemotherapy for children and young adults with acute nonlymphocytic leukemia in first remission. (1990) (73)
Transmembrane orientation of glycoproteins encoded by the v-fms oncogene (1985) (72)
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. (2010) (71)
Serum lactic dehydrogenase level has prognostic value in childhood acute lymphoblastic leukemia. (1985) (70)
High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X. (1988) (70)
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. (2017) (69)
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias (2006) (68)
Molecular Genetics of Childhood Leukemias (1998) (68)
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: A report from the CCG and COG (2009) (68)
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency (2012) (67)
Zebrafish as a model for myelopoiesis during embryogenesis. (2005) (67)
Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors (2014) (66)
Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb (2010) (66)
Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice (2016) (65)
Malignant Peripheral Nerve Sheath Tumors. (2016) (65)
Central Nervous System Leukemia in Children with Acute Nonlymphoblastic Leukemia (1985) (64)
Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. (2008) (63)
Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity. (1988) (63)
Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. (1999) (63)
The JAK 2 V 617 F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia , but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia (2005) (62)
Cytogenetic features and serum lactic dehydrogenase level predict a poor treatment outcome for children with pre-B-cell leukemia. (1986) (62)
Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: A report from the Children's Oncology Group (2013) (62)
Small genomic insertions form enhancers that misregulate oncogenes (2017) (61)
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2 (2020) (60)
Myb-Related Schizosaccharomyces pombecdc5p Is Structurally and Functionally Conserved in Eukaryotes (1998) (60)
Discovery of a selective inhibitor of Doublecortin Like Kinase 1 (2020) (59)
A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia (2006) (56)
Cytokinetically based induction chemotherapy and splenectomy for childhood acute nonlymphocytic leukemia. (1982) (55)
Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (1992) (55)
Biological variables in thoracic neuroblastoma: a Pediatric Oncology Group study. (1995) (54)
Deletion of Ip36 in childhood endodermal sinus tumors by two‐color fluorescence in situ hybridization: A pediatric oncology group study (1996) (54)
Zebrafish as a model organism for blood diseases (2003) (54)
Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells. (2014) (54)
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (53)
Zebrafish as a model for the study of human cancer. (2011) (53)
A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing (2014) (53)
Aberrant AKT activation drives well-differentiated liposarcoma (2011) (52)
A novel treatment of childhood lymphoblastic non-Hodgkin's lymphoma: early and intermittent use of teniposide plus cytarabine. (1985) (52)
Molecular Pathogenesis of MDS. (2005) (52)
Zebrafish sperm cryopreservation with N,N-dimethylacetamide. (2003) (50)
Unfavorable presenting clinical and laboratory features are associated with CALLA-negative non-T, non-B lymphoblastic leukemia in children. (1986) (50)
Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization (1997) (50)
Correlation between morphologic and other prognostic markers of neuroblastoma a study of histologic grade, DNA index, N‐myc gene copy number, and lactic dehydrogenase in patients in the pediatric oncology group (1993) (50)
p27KIP1 deletions in childhood acute lymphoblastic leukemia. (1999) (49)
Aminopeptidase N is directly sorted to the apical domain in MDCK cells (1990) (49)
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. (2004) (49)
BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals (2008) (48)
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies (2002) (47)
APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL (2017) (47)
p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis. (2011) (46)
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. (2010) (46)
Arsenic and apoptosis in the treatment of acute promyelocytic leukemia. (1998) (46)
Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X. (1991) (46)
Teniposide plus cytarabine improves outcome in childhood acute lymphoblastic leukemia presenting with a leukocyte count greater than or equal to 100 x 10(9)/L. (1987) (45)
Biological aspects of neuroblastomas identified by mass screening in Quebec. (2001) (45)
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. (2016) (45)
Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. (2011) (45)
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia (2014) (45)
BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines (2014) (45)
Identification of structural aberrations in cancer by SNP array analysis (2007) (44)
Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. (1997) (44)
Abnormalities of chromosomes 1 and 11 in Wilms' tumor. (1985) (43)
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry (2019) (43)
Parental smoking and alcohol consumption and risk of neuroblastoma. (2000) (42)
Continuous infusion high-dose cytosine arabinoside in refractory childhood leukemia. (1984) (42)
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish (2009) (42)
Two candidate downstream target genes for E2A-HLF. (1999) (41)
The E2A-HLF Oncoprotein ActivatesGroucho-Related Genes and SuppressesRunx1 (2001) (41)
Shared acquired genomic changes in zebrafish and human T-ALL (2011) (41)
A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. (2007) (41)
SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients (2008) (41)
Pharmacokinetics of teniposide (VM26) and etoposide (VP16-213) in children with cancer (2004) (40)
Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission. (1981) (40)
Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression (2009) (40)
The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. (2008) (39)
Comprar Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition | David E. Fisher | 9781416034308 | Saunders (2009) (39)
TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. (2017) (39)
Discovery of a selective irreversible BMX inhibitor for prostate cancer. (2013) (38)
Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X (2020) (38)
The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences (1986) (38)
Unexpectedly severe toxicity from intensive early treatment of childhood lymphoblastic leukemia. (1985) (37)
Quantitative variation of the common acute lymphoblastic leukemia antigen (gp100) on leukemic marrow blasts. (1984) (36)
ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression (2020) (36)
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches (2012) (36)
The AD1 and AD2 Transactivation Domains of E2A Are Essential for the Antiapoptotic Activity of the Chimeric Oncoprotein E2A-HLF (1998) (36)
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma (2018) (36)
Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio) (2002) (35)
E2A-HLF usurps control of evolutionarily conserved survival pathways (2001) (35)
HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia (2015) (34)
Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study. (1998) (34)
Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease (2015) (34)
Zebrafish B Cell Development without a Pre–B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes (2017) (34)
Age-Dependent Prognostic Effect by Mitosis-Karyorrhexis Index in Neuroblastoma: A Report from the Children's Oncology Group (2014) (34)
The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis (2016) (34)
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). (2010) (34)
Does MYCN Amplification Manifested as Homogeneously Staining Regions at Diagnosis Predict a Worse Outcome in Children with Neuroblastoma? A Children's Oncology Group Study (2006) (34)
The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells. (1998) (34)
Cell transformation mediated by homodimeric E2A-HLF transcription factors (1997) (33)
Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice (1999) (33)
Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies (2019) (32)
Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI (2009) (32)
Erratum: NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth (Proceedings of the National Academy of Sciences of the United States of America (2006) 103, 48, (18261-18266) DOI: 10.1073/pnas.0606108103) (2007) (32)
cpsf1 is required for definitive HSC survival in zebrafish. (2011) (32)
Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (1994) (31)
Development and characterization of pediatric osteosarcoma xenografts. (1990) (31)
L‐Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q‐ syndrome in a TP53‐independent way (2014) (31)
Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization. (1996) (30)
Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia (2016) (30)
Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors (2016) (30)
cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). (1996) (30)
Presenting features and treatment outcome of adolescents with acute lymphoblastic leukemia. (1990) (30)
Combined etoposide and 5-azacitidine in children and adolescents with refractory or relapsed acute nonlymphocytic leukemia: a Pediatric Oncology Group Study. (1987) (29)
Effective remission induction of refractory childhood acute nonlymphocytic leukemia by VP-16-213 plus azacitidine. (1981) (29)
Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma. (1989) (29)
Zebrafish myelopoiesis and blood cell development (2001) (28)
TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. (2005) (28)
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain (2016) (27)
Peripheral neuroblastic tumors with genotype–phenotype discordance: A report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee (2013) (27)
cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. (1999) (27)
Relation of tumor-cell ploidy to survival in children with medulloblastoma. (1993) (27)
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish fad24 (2009) (27)
Anti‐leukaemic activity of the TYK2 selective inhibitor NDI‐031301 in T‐cell acute lymphoblastic leukaemia (2017) (26)
Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. (2004) (26)
Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features. (1992) (26)
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma (2017) (26)
MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children’s oncology group (2017) (26)
The cytogenetics of childhood leukemia: clinical and biologic implications. (1988) (26)
Fishing for cancer models (2006) (26)
Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. (2009) (25)
MLL fusion genes in the 11q23 acute leukemias. (1996) (25)
Myb-Related Schizosaccharomyces pombe cdc5p Is Structurally and Functionally Conserved in Eukaryotes (1998) (25)
Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study. (1993) (25)
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study (2005) (25)
A leukemogenic twist for GATA1 (2002) (25)
Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells. (1995) (25)
The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study (2001) (24)
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy (2013) (24)
Central nervous system leukemia in children with acute nonlymphoblastic leukemia. (1985) (24)
Targeting transcription factors in acute leukemia in children. (2007) (24)
Coronavirus receptor specificity. (1993) (24)
Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. (2017) (23)
Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse (1999) (23)
Phenothiazines induce PP 2 A-mediated apoptosis in T cell acute lymphoblastic leukemia (2014) (23)
NOTCH1-Induced T-Cell Leukemia in Transgenic Zebrafish. (2006) (23)
Dominant-Interfering C/ebpα Stimulates Primitive Erythropoiesis in Zebrafish (2007) (23)
Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia (2016) (22)
Deletion of 1p36 in childhood endodermal sinus tumors by two-color fluorescence in situ hybridization: a pediatric oncology group study. (1996) (22)
Fluorescence in situ hybridization analysis of chromosome 1p36 deletions in human MYCN amplified neuroblastoma. (1998) (21)
E2A-HLF chimeric transcription factors in pro-B cell acute lymphoblastic leukemia. (1997) (21)
Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 (2012) (21)
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors (2020) (21)
HSP 90 inhibition leads to degradation of the TYK 2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia (2016) (20)
Construction and application of a zebrafish array comparative genomic hybridization platform (2009) (20)
Targeting oncogenic interleukin‐7 receptor signalling with N‐acetylcysteine in T cell acute lymphoblastic leukaemia (2015) (20)
Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia. (1986) (20)
Hemizygous deletions of chromosome band 16q24 in Wilms tumor: detection by fluorescence in situ hybridization. (1999) (20)
Knockdown of Zebrafish Fancd 2 Causes Developmental Abnormalities via p 53-Dependent Apoptosis (2003) (19)
Induction failures in childhood acute nonlymphocytic leukemia: etoposide/5-azacytidine for cases refractory to daunorubicin/cytarabine. (1986) (19)
The Chromatin Remodeling Factor CHD5 Is a Transcriptional Repressor of WEE1 (2014) (19)
DNA Microarrays in the Diagnosis and Management of Acute Lymphoblastic Leukemia (2004) (19)
State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: Summary report of workshop at the First International Symposium on childhood and adolescent non‐Hodgkin lymphoma, April 9, 2003, New York City, NY (2005) (19)
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma (2021) (19)
Comparison of Fluorescence In Situ Hybridization, Cytogenetic Analysis, and DNA Index Analysis to Detect Chromosomes 4 and 10 Aneuploidy in Pediatric Acute Lymphoblastic Leukemia: A Pediatric Oncology Group Study (1996) (18)
Cell transformation by ras and regulation of its protein product. (1993) (18)
Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines. (1999) (18)
A comparison of cytokinetically based versus intensive chemotherapy for childhood acute myelogenous leukemia. (1987) (18)
Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma (1992) (18)
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia (2018) (17)
The TAL 1 complex targets the FBXW 7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia (2013) (17)
Single-agent and combination chemotherapy with etoposide in the acute leukemias of childhood. (1982) (16)
Two Candidate Downstream Target Genes for E2A-HLF (1999) (16)
Zebrafish models of leukemia. (2017) (16)
Turning on a dimer: new insights into MLL chimeras. (2003) (16)
Computer simulation of the cellular immune response to malignant lymphoid cells: logic of approach, model design and laboratory verification. (1981) (16)
TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia (2015) (15)
Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish. (2007) (15)
Prognostic value of cellular DNA content in acute lymphoblastic leukemia of childhood. (1987) (15)
Specific induction of CD33 expression by E2A–HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor (2010) (15)
CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome (2005) (15)
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors (2012) (15)
Clinical Significance of CD 34 Expression in Childhood Acute Lymphoblastic Leukemia (14)
Changes in Cell Surface Antigen Expression During Myelocytic and Monocytic Cell Differentiation (1984) (14)
Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish (2019) (14)
Use of clinical and laboratory features to define prognostic subgroups in B-precursor acute lymphoblastic leukemia: experience of the Pediatric Oncology Group. (1993) (14)
Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells* (2009) (14)
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors (2019) (14)
TYK 2 – STAT 1 – BCL 2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia (2013) (14)
Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma (2021) (14)
Studying the peripheral sympathetic nervous system and neuroblastoma in zebrafish. (2016) (13)
Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish. (2010) (13)
Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis. (2012) (13)
Development of the peripheral sympathetic nervous system in zebrafish. (2004) (13)
Loss of function tp53 mutations do not accelerate the onset of myc‐induced T‐cell acute lymphoblastic leukaemia in the zebrafish (2014) (13)
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma (2021) (13)
Cyclophosphamide/etoposide: effective reinduction therapy for children with acute nonlymphocytic leukemia in relapse. (1985) (13)
Inverse relationship between megakaryocyte buoyant density and maturity (1986) (12)
Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children (2009) (12)
Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. (1998) (12)
Osteosarcoma, fibrous dysplasia, and a chromosomal abnormality in a 3‐year‐old child (1980) (12)
Absence of Biallelic TCR (cid:1) Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia (2010) (12)
MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation (2021) (11)
Impact of RNA extraction from limited samples on microarray results (2003) (11)
Sensitivity to macrophage-mediated cytostasis is cell cycle dependent. (1982) (11)
GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma (2021) (11)
Neuroblastoma and Its Zebrafish Model. (2016) (11)
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors (2020) (10)
From bench to patient: model systems in drug discovery (2015) (10)
Screening for neuroblastoma (NB) in North America: the Quebec Project. (1994) (10)
Acute lymphocytic leukemia: Biological markers of clinical response (1982) (9)
Limiting toxicities during intensified remission induction chemotherapy for childhood acute lymphocytic leukemia. (1987) (9)
Subiocalization of the chromosome 5 breakpoint of the 3;5 translocation in myelodysplastic syndromes and acute myeloid leukemia (1992) (9)
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma (2021) (9)
Zebrafish sperm cryopreservation. (2004) (9)
Determination of the significance of in vitro blast cell [3H]thymidine labelling indices obtained initially and serially during induction therapy of acute non-lymphocytic leukemia. (1982) (8)
The Chimeric E2A-HLF Transcription Factor Abrogates p53-Induced Apoptosis in Myeloid Leukemia Cells (1998) (8)
No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3. (2002) (8)
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types (2020) (8)
Recent results from Total Therapy Study X for standard and high risk acute lymphoblastic leukemia in children: recognition of new clinical and biologic risk features. (1985) (8)
Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL) (2021) (7)
Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors (2020) (7)
Gene expression profiling: will it complement or replace immunophenotyping? (2003) (6)
Clinical and cell kinetic studies of the effects of the epipodophyllotoxin VP16-213 during therapy of refractory acute nonlymphocytic leukemia (2004) (6)
Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia (2014) (6)
mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues (2011) (6)
Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL (2021) (6)
A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene (1993) (5)
Oncogenic role of "master" transcription factors in human leukemias and sarcomas: a developmental model. (1995) (5)
Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia (2018) (5)
Macrophage-mediated cytostatic activity blocks lymphoblast cell cycle progression independently in both G1 phase and S phase. (1983) (5)
Fusion of NUP214 to ABL1 on amplified extrachromosomal elements in T-ALL. (2004) (4)
Three molecular determinants of malignant conversion and their potential as therapeutic targets. (1999) (4)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (4)
Cancer therapy resistance: chasing epigenetics (2014) (4)
Cytogenetic abnormalities in two cases of neuroblastoma. (1994) (4)
ANALYSIS OF THE IMMUNE RESPONSE TO MALIGNANT CELLS BY COMPUTER SIMULATION. (1982) (4)
Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping. (1998) (4)
The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications. (1985) (4)
Ccdc 94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p 53 (2012) (3)
Sublocalization of the chromosome 5 breakpoint of the 3;5 translocation in myelodysplastic syndromes and acute myeloid leukemia. (1992) (3)
Both p53-Dependent and -Independent Pathways Contribute to Erythroid Dysplasia in a Zebrafish Model for Diamond Blackfan Anemia. (2009) (3)
A phase I study of decitabine (DCT) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in the treatment of relapsed or refractory solid tumors: A Children's Oncology Group Study (2005) (3)
Molecular biology of leukemia and lymphoma. (1994) (3)
The Chimeric E 2 A-HLF Transcription Factor Abrogates p 53-Induced Apoptosis in Myeloid Leukemia Cells (1998) (3)
Molecular pathways in T-cell acute lympho-blastic leukemia: ramifications for therapy. (2004) (3)
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. (2011) (3)
suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma. (2020) (3)
High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T‐cell acute lymphoblastic leukemia (2019) (3)
Small molecules thwart crash and burn (2005) (2)
Epigenetic Therapy Inhibits NUP98-HOXA9-Mediated Myeloid Disease – Decitabine and Valproic Acid Work Synergistically to Rescue Normal Hematopoiesis in Transgenic Zebrafish. (2012) (2)
Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia (2016) (2)
Epigenetic Suppression of the CTNNA1 Gene, Encoding the α-Catenin Protein, which Is Located in the 5q31 Critical Deleted Region in Malignant Myeloid Disorders with del(5q). (2004) (2)
Retraction Notice to: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2 (2022) (2)
Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice (2011) (2)
Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway? (2010) (2)
Fusion genes and their hybrid proteins in human leukemias and lymphomas. (1995) (2)
Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage. (2004) (2)
Large Regions of Uniparental Disomy (UPD) Establish Clonal Hematopoietic Stem Cell Selection in a Subset of Myelodysplastic Syndrome (MDS) Patients with Normal Bone Marrow Cell Karyotypes. (2007) (2)
Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia, (2011) (2)
Activating FLT 3 Mutations in CD 117 / KIT Positive T-Cell Acute Lymphoblastic Leukemias (2004) (2)
Apoptosis: Analysis of Cell Death in Zebrafish (2011) (1)
Abstract 2007: Transcriptional regulatory program controlled by the oncogenic transcription factor LMO1 in neuroblastoma (2016) (1)
Cleavage and Polyadenylation Specificity Factor 1 Is Required for Definitive Hematopoietic Stem Cell Survival In Zebrafish. (2010) (1)
Subject Index Vol. 52, 1989 (1989) (1)
Abstract 2352: Defining a pediatric cancer dependency map (2018) (1)
A Role for fbxo5 in Zebrafish Myelopoiesis. (2005) (1)
Selectivity and binding kinetics of mTOR inhibitors 1 Kinome-wide selectivity profiling of ATP-competitive mTOR ( mammalian target of rapamycin ) inhibitors and characterization of their binding kinetics (2011) (1)
Abstract 1287: Exploring somatic DNA structural alteration and aberrant genomic interactions in cancer through GenomePaint (2018) (1)
Frequent Deletion of Ink4a/Mts1 in Pediatric Acute Lymphoblastic-Leukemia (1994) (1)
Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss (2021) (1)
Abstract 1353: Inactivation of ribosomal protein L22 promotes transformation by induction of Lin28B (2012) (1)
Identification of TAL1/SCL Target Genes through siRNA and Microarray Expression Analysis. (2004) (1)
L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner (2012) (1)
Chromosomal Translocations and Gene Rearrangements in Acute Lymphoblastic Leukaemia (2015) (1)
Abstract 4135:c-MYCdrives a subset of high-risk pediatric neuroblastoma and is activated through mechanisms including enhancer hijacking and focal enhancer amplification (2018) (1)
Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML (2015) (1)
Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family. (2000) (1)
Constellations of genetic abnormalities predict clinical outcome in childhood malignancies. (1989) (1)
Abstract 4296: Activated ALK accelerates the onset of neuroblastoma in MYCN-transgenic zebrafish (2011) (1)
suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma. (2020) (1)
HOXB9 Is Aberrantly Expressed in Blast Cells in a Subset of Acute Myeloid Leukemia Patients and Supports Proliferation of AML Cell Lines (2004) (1)
Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN (2020) (1)
Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells (2014) (1)
Genome-Wide Transcriptional Regulatory Networks Downstream of TAL1/SCL in T-Cell Acute Lymphoblastic Leukemia. (2004) (1)
Targeting ganglioneuromas with mTOR inhibitors (2021) (1)
Abstract 3871: Modeling the chromatin and transcriptional landscape of MYC and MYCN driven neuroblastoma in zebrafish (2017) (1)
Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes (2017) (1)
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. (2022) (1)
-Catenin stabilization stalls the transition from Double Positive to Single Positive stage and predisposes thymocytes to malignant transformation. Stabilization of β -catenin induces lymphomas (2007) (1)
Abstract 2809: Pathway dependence on the tyrosine kinase TYK2 in T-cell acute lymphoblastic leukemia (2011) (1)
Clinical and Biological Implications of Chromosomal Translocations and Ploidy in Childhood Acute Lymphoblastic Leukemia (1993) (1)
Abstract 4252: Activated ALK collaborates with MYCN in neuroblastoma pathogenesis (2012) (1)
Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor (2012) (1)
Distribution and lysis of weakly and strongly immunogenic malignant lymphoid cells in normal and immune mice: effects of prior exposure to heat or X-irradiation. (1984) (1)
Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry (2020) (1)
Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia. (2010) (1)
Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy. (2010) (0)
Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model (2014) (0)
Abstract 476: Loss of chd5-mediated tumor suppression accelerates MYCN-driven neuroblastoma tumorigenesis in zebrafish (2015) (0)
E2A-HLF Fusion Transcription Factor Mediating Aberrant Expression of LMO2 in B-Precursor ALL with t(17;19). (2006) (0)
Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor (2019) (0)
Absence of T-Cell Receptor Gene Rearrangements Predicts Induction Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia. (2009) (0)
Abstract IA17: Pathway dependence and drug synergism in NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model (2018) (0)
Contents, Vol. 52, 1989 (1989) (0)
Abstract 3408: Targeting cancer cells with potent activators of the PP2A protein phosphatase tumor suppressor (2020) (0)
Abstract 5014: Drug discovery for NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model (2017) (0)
Abstract 1574: Computational approach for discovery of regulatory noncoding variants in cancer (2017) (0)
Intensified chemotherapy for childhood lymphoblastic leukemia: modifications and results of induction treatment in St. Jude Study XI. (1988) (0)
Targeting the Notch Pathway in Cancer (2007) (0)
STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma (2022) (0)
Does MYCN AmplificationManifested as Homogeneously Staining Regions at Diagnosis Predict aWorse Outcome in Childrenwith Neuroblastoma ? AChildren ’ s Oncology Group Study (2006) (0)
Gene expression arrays and the therapist's dilemma (2004) (0)
Frequent Deletion of p16*NK4a/MTSl and in Pediatric Acute Lymphoblastic Leukemia (2011) (0)
Development and Characterization of Pediatrie Osteosarcoma Xenografts1 (2006) (0)
1 Activation of the LMO 2 oncogene through a somatically acquired 1 neomorphic promoter in T-Cell Acute Lymphoblastic Leukemia 2 3 (2017) (0)
Abstract B43: Role of activated SHP2 in high-risk neuroblastoma pathogenesis (2014) (0)
Acute Injury Metalloproteinase 13 Signaling in Response to Macrophages Mediated by JNK-Matrix In Vivo Interstitial Migration of Primitive (2008) (0)
Molecular Cloning, Expression, and Chromosomal Localization of the Gene Encoding a Human Myeloid Membrane Antigen (gpl50) (2013) (0)
The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia (2010) (0)
Targeting Notch Pathways (2019) (0)
Abstract 1540: Creating faithful genetic zebrafish models of pediatric high grade gliomas and MPNSTs (2017) (0)
MEIS1 Is a Required Transcription Factor for AML Cell Proliferation. (2006) (0)
Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma (2020) (0)
Near-diploid tumor stem lines in patients with osteosarcoma (1989) (0)
Abstract 2062: Selective gene dependencies inMYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (0)
NOTCH1 Signaling Defines a Leukemia Initiating Cell Population in T-Cell Acute Lymphoblastic Leukemia (2011) (0)
A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia (2013) (0)
Is Associated With a Poor Prognosis in Childhood Acute Lymphoblastic Leukemia (2016) (0)
The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL (2022) (0)
Emi1 Maintains Genomic Integrity during Zebraﬁsh Embryogenesis and Cooperates with p53 in Tumor Suppression (cid:1) (2009) (0)
Induction of death receptors for TRAIL, a cytotoxic factor for GVL effect, by oncogenic fusion E2A-HLF derived from t(17;19)-positive acute lymphoblastic leukemia (2007) (0)
CD34+ Cell Selection Is Required to Accurately Measure HOXA9 Levels by Quantitative RT-PCR in Patients with Myelodysplastic Syndrome. (2004) (0)
Development and Characterization of Pediatrie Osteosarcoma Xenografts 1 (2006) (0)
Investigator profile. An interview with A. Thomas Look, M.D. Interview by Vicki Glaser. (2005) (0)
Abstract LB-162: The onset ofMYCNoverexpression-induced neuroblastoma is accelerated byALKmutation in zebrafish (2010) (0)
Abstract 1957: Molecular pathogenesis and drug synergism in a zebrafish model of high risk neuroblastoma (2017) (0)
Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors (2020) (0)
Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia (2010) (0)
Abstract IA19: MYC activation through enhancer hijacking or focal enhancer amplification drives a subset of high-risk pediatric neuroblastoma (2018) (0)
1 TYK 2-STAT 1-BCL 2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia (2013) (0)
acute lymphoblastic The JAK 2 V 617 F activating mutation occurs in chronic myelomonocytic (2005) (0)
Pivotal Role of Survivin in Leukemogenesis by E2A-HLF Chimeric Transcription Factor. (2005) (0)
Human Nucleophosmin (NPM1) Perturbs Myeloid Development in Zebrafish in Vivo (2008) (0)
Therapy of Childhood Leukemia: Understanding Success and Failure (1991) (0)
Title: c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification Authors: (2017) (0)
NUP98-HOXA9 Reprograms Embryonic Hematopoiesis, Suppresses Cellular Apoptosis, and Causes Malignant Tissue Infiltrates in Transgenic Zebrafish. (2009) (0)
Abstract IA8: A new class of drugs active in T-ALL is revealed in a zebrafish screen (2014) (0)
Abstract 4313: Mouse model of human T-cell acute lymphoblastic leukemia stem cells (2010) (0)
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells by XPO1 inhibitors (2022) (0)
RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia (2010) (0)
Frequent Deletion of p 16 * NK 4 a / MTSl and i Pediatric Acute Lymphoblastic Leukemia (2002) (0)
Comprar Oncology of Infancy and Childhood - Expert Consult - Online and Print | David E. Fisher | 9781416034315 | Saunders (2008) (0)
A putative stemness biomarker gene set suggests γ-secretase inhibitor targets self-renewal and pluripotency programs in tumors (2008) (0)
Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL. (2006) (0)
FISH法を用いた神経芽腫における1番染色体短腕(1P)欠失の検索 (1998) (0)
HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase (2013) (0)
Abstract B22: Cell state and lineage specification are controlled by epigenetic landscapes regulating the core transcriptional regulatory circuitry in pediatric neuroblastoma (2020) (0)
The Role of RNA Helicase Dead Box 18 in Zebrafish Hematopoiesis and Human MDS (2008) (0)
A Tamoxifen-Dependent Conditional Model of MYC-Induced T Cell Acute Lymphoblastic Leukemia in the Zebrafish. (2007) (0)
Abstract 2004: Nucleation of transcriptional super-enhancers at tumor oncogenes by small insertions (2016) (0)
Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter (2016) (0)
Unraveling Neuroblastoma Pathogenesis with the Zebrafish (2018) (0)
LYMPHOID NEOPLASIA Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia (2017) (0)
Abstract 1011: NOTCH1 signaling is essential for leukemia initiating cell self-renewal in T-ALL (2012) (0)
Relationships of Cell Biology to Therapy in Childhood Leukemia (1987) (0)
Abstract 3583: Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia (2016) (0)
Blackfan anemia and del ( 5 q ) MDS by activating the L-leucine improves the anemia and developmental defects associated (2012) (0)
Oncogenic HOXA9 Inhibits Cellular Apoptosis Induced by Ionizing Radiation (IR) in Transgenic Zebrafish (2008) (0)
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State (2023) (0)
Deletion of the short arm of chromosome 1 in childhood endodermal sinus tumors by fluorescence in situ hybridization (1995) (0)
Induction of CD33 Expression in B-Precursor ALL by E2A-HLF Fusion Transcription Factor Derived from t(17;19). (2005) (0)
Transforming Glycoprotein in the Absence of Feline Leukemia Virus (0)
Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing Puma . (2005) (0)
Targeting Notch in cancer with gamma-secretase inhibitors (2007) (0)
Abstract 39: XPO1 inhibitor, KPT-8602, is well tolerated and highly active against AML blasts and LICs (2017) (0)
DMM023036 1171..1174 (2015) (0)
Oncogene Amplification in Pediatrie Brain Tumors' (2006) (0)
Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X (2020) (0)
Zebrafish Models of BCR-ABL-Induced Leukemogenesis (2005) (0)
Zebrafish Model of NF1 for Structure-Function Analysis, Mechanisms of Glial Tumorigenesis, and Chemical Biology (2013) (0)
Review The Use of Zebrafish to Understand Immunity (2004) (0)
Childhood Leukemias: Molecular genetics of acute lymphoblastic leukemia (2006) (0)
Slug Plays an Essential Role in the Radioprotection of Hematopoietic Progenitors In Vivo by Antagonizing p53-Mediated Apoptotic Pathways. (2004) (0)
Selectivity and binding kinetics of mTOR inhibitors 2 (2011) (0)
Abstract 2433: Loss of chd5-mediated gene repression synergizes with MYCN to accelerate neuroblastoma tumorigenesis in zebrafish (2016) (0)
CHAPTER 23 – Chromosomal Translocations in B-Cell Leukemias and Lymphomas (2004) (0)
LEF1 Is a Tumor Suppressor in T Cell Acute Lymphoblastic Leukemia (2008) (0)
Abstract 801: A zebrafish model ofNF1-mutant melanomas that lack activating mutations ofBRAForNRAS (2017) (0)
Molecular Analysis of Chromosomal Abnormalities in Childhood Acute Lymphoblastic Leukemia (1991) (0)
transgenic zebrafish Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of (2013) (0)
Supplemental Methods PCR analysis on genomic translocations Genomic (2017) (0)
Abstract 681: Using a genome-editing approach for the stepwise establishment of zebrafish models of pediatric high-grade gliomas and MPNSTs (2016) (0)
Function of Nucleophosmin in Zebrafish Hematopoiesis (2007) (0)
Oncogene activation in hematopoietic malignancies. (1987) (0)
Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia (2010) (0)
NK cells and NK receptors (PP-007) (2010) (0)
Abstract A37: Immunohistochemical detection of MYCN protein and MYC protein identifies highly aggressive neuroblastomas (2015) (0)
Emi1 Is Required for Normal Cell Cycle Progression in Zebrafish Myelopoiesis and Likely Functions as a Haploinsufficient Tumor Suppressor on Chromosome 6q in Human Leukmias. (2006) (0)
Abstract 356: Role of the LMO1 oncogene in neuroblastoma pathogenesis. (2013) (0)
Pten Inactivating Mutations Promote Loss of MYC “Oncogene Addiction” in a Conditional Zebrafish Model of T-ALL. (2009) (0)
Modifier genetics in zebrafish identify Chk1 and an associated survival pathway as targets for pharmacotherapy of MDS/AML with P53 mutations. (2006) (0)
Cloning and characterization of the sympathetic nervous system mutant, Sym3, in zebrafish (2007) (0)
Abstract 974: A selective Notch1 mAb targets leukemia progenitor cells in T-ALL (2011) (0)
STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia (2022) (0)
A New Recurrent 9q34 Duplication in Pediatric T-Cell Acute Lymphoblastic Leukemia. (2005) (0)
cpsf1 is required for deﬁnitive HSC survival in zebraﬁsh (2011) (0)
Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma (2020) (0)
Abstract 1180: The TCA cycle transferase DLST is critical for MYC-mediated leukemogenesis (2016) (0)
Abstract 2953: Selective activity of XPO1 inhibitors in TET2-mutant myeloid malignancies (2019) (0)
The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia (2012) (0)
p53 pathway inactivation drives SMARCB1-deficient p53-wildtype epithelioid sarcoma onset indicating therapeutic vulnerability through MDM2 inhibition. (2022) (0)
IL3BP1, A Transcription Factor with Dual Function (1996) (0)
Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells (2013) (0)
Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors (2022) (0)
CHROMOSOMAL REGIONS CONTAINING NEW CANDIDATE ONCOGENES AND TUMOR SUPPRESSORS IN WILMS TUMOR DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION. • 894 (1996) (0)
8 – Animal Models: Flies, Fish, and Yeast (2015) (0)
Evaluation of KPT-SINE (Selective Inhibitors of CRM1-Mediated Nuclear Export) in AML and T-ALL. (2012) (0)
Leukemias and Lymphomas: Genetics (2006) (0)
O22: A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia (2005) (0)
MYBL2 Is a Candidate Tumor Suppressor Gene In MDS (2010) (0)
Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma (2021) (0)
Abstract 80: Activated SHP2 collaborates with MYCN in neuroblastoma tumorigenesis (2014) (0)

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