Thomas M. Roberts
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American biologist
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Thomas M. Robertsbiology Degrees
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Genetics
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#788
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#239
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Molecular Biology
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#866
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#183
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Biology
Thomas M. Roberts's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Genetics Stanford University
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(Suggest an Edit or Addition)Thomas M. Roberts's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Targeting the phosphoinositide 3-kinase pathway in cancer (2009) (2371)
- CDK4/6 inhibition triggers anti-tumor immunity (2017) (836)
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK (1992) (833)
- COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation (2010) (778)
- A histone H3 lysine 27 demethylase regulates animal posterior development (2007) (758)
- Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation (1985) (699)
- MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS (2012) (686)
- The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases (2007) (661)
- Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis (2008) (646)
- Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. (1992) (614)
- KRAS and YAP1 Converge to Regulate EMT and Tumor Survival (2014) (613)
- Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene (2007) (613)
- Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. (1999) (593)
- Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A (1990) (558)
- Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity (1987) (518)
- A Genetic Screen for Candidate Tumor Suppressors Identifies REST (2005) (494)
- An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). (2013) (485)
- Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src (1987) (474)
- Cloning of the β subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family (1987) (473)
- Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. (1997) (427)
- Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor (1989) (376)
- Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. (1988) (370)
- How the λ repressor and cro work (1980) (365)
- A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. (2003) (336)
- Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency (1987) (334)
- PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer (2018) (305)
- Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. (2003) (301)
- The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells (2005) (295)
- Interaction of the protein kinase Raf-1 with 14-3-3 proteins. (1994) (294)
- Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways (1997) (278)
- Oncogenes, growth factors, and signal transduction. (1989) (257)
- The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival (2017) (230)
- Presence of an SH2 domain in the actin-binding protein tensin. (1991) (220)
- The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation (2006) (217)
- DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. (1997) (211)
- Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. (1987) (206)
- How nematode sperm crawl. (2002) (205)
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation (2014) (205)
- Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen (1997) (203)
- PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis (2011) (202)
- The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. (2005) (202)
- Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. (2002) (195)
- Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells (2004) (193)
- A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells (1997) (185)
- The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. (1993) (183)
- Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin (1980) (183)
- Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts. (1988) (180)
- The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. (1993) (172)
- An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase (1991) (168)
- Phosphatidylinositol metabolism and polyoma-mediated transformation. (1986) (168)
- Association of polyomavirus middle tumor antigen with 14-3-3 proteins. (1994) (161)
- The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development (2010) (160)
- Caenorhabditis elegans spermatozoan locomotion: amoeboid movement with almost no actin (1982) (157)
- Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. (1994) (151)
- Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish (2006) (141)
- Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells (1988) (137)
- The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers (2008) (136)
- Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. (1992) (136)
- Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. (2000) (135)
- Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. (2004) (133)
- Histone H 4 K 20 / H 3 K 9 demethylase PHF 8 regulates zebrafish brain and craniofacial development (2010) (132)
- Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding (2008) (132)
- Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells* (1999) (125)
- Schwann Cell Proliferative Responses to cAMP andNf1 Are Mediated by Cyclin D1 (2001) (123)
- A general method for maximizing the expression of a cloned gene. (1979) (119)
- Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells (1987) (118)
- The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. (2017) (117)
- A unique cytoskeleton associated with crawling in the amoeboid sperm of the nematode, Ascaris suum (1989) (117)
- Should individual PI3 kinase isoforms be targeted in cancer? (2009) (116)
- Reconstitution In Vitro of the Motile Apparatus from the Amoeboid Sperm of Ascaris Shows That Filament Assembly and Bundling Move Membranes (1996) (115)
- Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner (2007) (114)
- The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. (2012) (111)
- Determination of the nuclear DNA content of Saccharomyces cerevisiae and implications for the organization of DNA in yeast chromosomes. (1977) (110)
- Targeting PI3K signaling as a therapeutic approach for colorectal cancer. (2011) (107)
- Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase(*) (1995) (106)
- Membrane and cytoplasmic proteins are transported in the same organelle complex during nematode spermatogenesis (1986) (105)
- Acting like Actin: The Dynamics of the Nematode Major Sperm Protein (Msp) Cytoskeleton Indicate a Push-Pull Mechanism for Amoeboid Cell Motility (2000) (105)
- Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo. (1991) (103)
- Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production (1986) (103)
- PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum* (2006) (97)
- Delivery strategies and potential targets for siRNA in major cancer types. (2016) (96)
- The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function (1997) (96)
- Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. (1991) (95)
- Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. (1992) (95)
- Characterization of the DNA from the dinoflagellate crypthecodinium cohnii and implications for nuclear organization (1975) (95)
- Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. (1990) (94)
- DEF-1/ASAP1 Is a GTPase-activating Protein (GAP) for ARF1 That Enhances Cell Motility through a GAP-dependent Mechanism* (2002) (92)
- Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri (*) (1995) (90)
- A Developmentally Regulated Switch Directs Regenerative Growth of Schwann Cells through Cyclin D1 (2000) (90)
- A plasmid cloning vehicle allowing a positive selection for inserted fragments. (1980) (90)
- Expression of the human fibroblast interferon gene in Escherichia coli. (1980) (89)
- Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases (2016) (89)
- Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. (2001) (88)
- Monoclonal antibodies that recognize a polypeptide antigenic determinant shared by multiple Caenorhabditis elegans sperm-specific proteins (1986) (87)
- TMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing. (2021) (85)
- Association of Polyomavirus Middle Tumor Antigen with Phospholipase C-γ1(*) (1995) (85)
- Regulation of G 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase y Akt pathway (1999) (84)
- How the lambda repressor and cro work. (1980) (83)
- Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri (1995) (82)
- PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy (2017) (81)
- Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line (1990) (80)
- The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. (1996) (80)
- The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens (1992) (79)
- Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. (1986) (79)
- Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen (1990) (79)
- Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. (1993) (78)
- Cell biology of nematode sperm. (1995) (77)
- Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A (1995) (77)
- Polyoma virus major capsid protein, VP1. Purification after high level expression in Escherichia coli. (1985) (76)
- PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. (2016) (75)
- Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial. (2019) (75)
- Maximizing gene expression on a plasmid using recombination in vitro. (1979) (73)
- Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells (1991) (71)
- Sequence of cro gene of bacteriophage lambda (1977) (71)
- Functional genetics and experimental models of human cancer. (2004) (71)
- Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer (2016) (70)
- Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. (2016) (69)
- Characterization of pp85, a target of oncogenes and growth factor receptors (1990) (68)
- PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context (2014) (68)
- 2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum. (1996) (67)
- K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo (2012) (66)
- Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice (2000) (66)
- Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. (1990) (66)
- Centripetal flow of pseudopodial surface components could propel the amoeboid movement of Caenorhabditis elegans spermatozoa (1982) (65)
- Tangled Webs: Evidence of Cross-Talk Between c-Raf-1 and Akt (1999) (64)
- Membrane flow during nematode spermiogenesis (1982) (64)
- PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α (2017) (63)
- The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. (2004) (62)
- Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells (1992) (61)
- Localized Depolymerization of the Major Sperm Protein Cytoskeleton Correlates with the Forward Movement of the Cell Body in the Amoeboid Movement of Nematode Sperm (1999) (61)
- Retraction in Amoeboid Cell Motility Powered by Cytoskeletal Dynamics (2003) (60)
- Structure and macromolecular assembly of two isoforms of the major sperm protein (MSP) from the amoeboid sperm of the nematode, Ascaris suum. (1992) (59)
- Cellular proteins that associate with the middle and small T antigens of polyomavirus (1988) (59)
- A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice (2010) (57)
- Platelet-derived Growth Factor-induced Formation of Tensin and Phosphoinositide 3-Kinase Complexes* (1996) (56)
- Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. (1997) (54)
- Surveillance mechanism linking Bub1 loss to the p53 pathway (2007) (54)
- Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. (2009) (53)
- A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis (2008) (53)
- The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus (1988) (53)
- Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. (1992) (53)
- The blue-green alga agmenellum quadruplicatum contains covalently closed DNA circles (1976) (53)
- Regulation of the Ascaris major sperm protein (MSP) cytoskeleton by intracellular pH. (1994) (52)
- Mechanisms of transformation by polyoma virus middle T antigen. (1989) (52)
- The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila (2002) (52)
- Fine (2-5-nm) filaments: new types of cytoskeletal structures. (1987) (52)
- Cell Density Modulates Protein-tyrosine Phosphorylation* (1998) (52)
- Human tumor mutants in the p110alpha subunit of PI3K. (2006) (51)
- Abundant expression of polyomavirus middle T antigen and dihydrofolate reductase in an adenovirus recombinant (1987) (51)
- Induction of p53-Independent Apoptosis by Simian Virus 40 Small t Antigen (2001) (51)
- Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A (1999) (51)
- Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. (2003) (48)
- Centripetal flow and directed reassembly of the major sperm protein (MSP) cytoskeleton in the amoeboid sperm of the nematode, Ascaris suum. (1991) (47)
- Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. (2014) (47)
- PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target (2006) (46)
- Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. (2013) (46)
- Nematode sperm locomotion. (1995) (45)
- A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm (2003) (44)
- Signal transduction pathways involving the raf proto-oncogene (1994) (43)
- Synthesis of simian virus 40 t antigen in Escherichia coli. (1979) (43)
- Tyrosine phosphorylations in vivo associated with v-fms transformation (1988) (42)
- Bub1: Escapades in a Cellular World (2007) (41)
- Serine 257 Phosphorylation Regulates Association of Polyomavirus Middle T Antigen with 14-3-3 Proteins (1998) (41)
- Purification of biologically active simian virus 40 small tumor antigen. (1983) (41)
- How the assembly dynamics of the nematode major sperm protein generate amoeboid cell motility. (2001) (40)
- PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers (2016) (40)
- An F 876 L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV 3100 ( Enzalutamide ) (2013) (39)
- DEF-1, a Novel Src SH3 Binding Protein That Promotes Adipogenesis in Fibroblastic Cell Lines (1999) (39)
- A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis (2015) (39)
- Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells (1990) (39)
- Supramolecular assemblies of the Ascaris suum major sperm protein (MSP) associated with amoeboid cell motility. (1994) (38)
- Targeting the phosphoinositide 3-kinase ( PI 3 K ) pathway in cancer (2011) (38)
- A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity (1990) (38)
- Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. (1996) (37)
- A technique for expressing eukaryotic genes in bacteria. (1980) (37)
- Behavioral responses of Schistosoma mansoni miracidia in concentration gradients of snail-conditioned water. (1979) (36)
- Structural basis for amoeboid motility in nematode sperm (1998) (36)
- The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. (1986) (36)
- pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression (2000) (35)
- Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers (2019) (35)
- Hydrostatic Pressure Shows That Lamellipodial Motility in Ascaris Sperm Requires Membrane-associated Major Sperm Protein Filament Nucleation and Elongation (1998) (35)
- Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells (1984) (33)
- Characterization of middle T antigen expressed by using an adenovirus expression system (1987) (33)
- Tyrosine receptor kinase B is a drug target in astrocytomas (2017) (32)
- 2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. (2002) (32)
- Nematode sperm: amoeboid movement without actin. (1997) (32)
- The motile major sperm protein (MSP) from Ascaris suum is a symmetric dimer in solution. (1996) (31)
- The p110α Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation (2007) (31)
- Lck Unique Domain Influences Lck Specificity and Biological Function (*) (1995) (31)
- Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function (2011) (30)
- Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo (1986) (30)
- MSP dynamics drives nematode sperm locomotion. (2005) (29)
- CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. (2017) (29)
- Polyomavirus middle T-antigen NPTY mutants (1992) (28)
- Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. (1990) (28)
- The motile major sperm protein (MSP) of Ascaris suum forms filaments constructed from two helical subfilaments. (1994) (27)
- Membrane Insertion by Anthrax Protective Antigen in Cultured Cells (2005) (27)
- Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. (1990) (27)
- Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. (2009) (27)
- PIK3CAH1047R and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling (2015) (27)
- Characterization of a blue-green algal genome. (1977) (26)
- The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins (1989) (26)
- Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm. (2012) (26)
- Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer (2021) (26)
- Platelet-derived Growth Factor Stimulation of Monocyte Chemoattractant Protein-1 Gene Expression Is Mediated by Transient Activation of the Phosphoinositide 3-Kinase Signal Transduction Pathway* (1999) (26)
- Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase. (1992) (25)
- Immunization against the polyoma tumor‐specific transplantation antigen (TSTA) with polyoma T‐antigens (1988) (24)
- Combination of KRAS gene silencing and PI3K inhibition for ovarian cancer treatment. (2019) (24)
- Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins (2018) (24)
- A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. (2007) (24)
- Membrane-substrate contact under the spermatozoon of Caenorhabditis elegans, a crawling cell that lacks filamentous actin. (1984) (23)
- Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro (1988) (22)
- Expression of polyoma early gene products in E. coli. (1985) (22)
- Regulates Glutamine Metabolism through the eIF 4 B-Dependent Control of c-Myc Translation (2014) (22)
- Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation (2014) (22)
- Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. (2005) (22)
- Pairing of Leucochloridiomorpha constantiae (Mueller, 1935) (Trematoda) in vitro, in the chick and on the chorioallantois. (1972) (22)
- Oncogenes and protein kinases in neuronal growth-factor action. (1993) (21)
- Crawling caenorhabditis elegans spermatozoa contact the substrate only by their pseudopods and contain 2‐nm filaments (1983) (21)
- Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss (2016) (21)
- Chemical attraction between adults of Nippostrongylus brasiliensis: description of the phenomenon and effects of host immunity. (1977) (20)
- Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. (1995) (20)
- PI3 kinase alpha and delta promote hematopoietic stem cell activation. (2019) (20)
- The role of filament-packing dynamics in powering amoeboid cell motility (2008) (19)
- STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer (2022) (19)
- Homogeneous purification of human recombinant GST-Akt/PKB from Sf9 cells. (1999) (19)
- Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. (1991) (19)
- Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives. (1998) (19)
- A direct role for c-fos in AP-1-dependent gene transcription. (1990) (18)
- In Ascaris sperm pseudopods, MSP fibers move proximally at a constant rate regardless of the forward rate of cellular translocation. (1995) (17)
- Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens (2014) (16)
- The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity (2000) (16)
- The Development and Motility of Caenorhabditis elegans Spermatozoa. (1982) (16)
- Polyoma small T antigen triggers cell death via mitotic catastrophe (2014) (16)
- NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways (2016) (16)
- Construction of plasmids that produce phage P22 repressor. (1981) (16)
- Cytoskeleton dynamics powers nematode sperm motility. (2005) (16)
- Chemical attraction between adults of Nippostrongylus brasiliensis characterization of the substance which attracts females. (1977) (15)
- Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub 1 (2004) (15)
- Major sperm protein (2005) (15)
- Solution structure of the motile major sperm protein (MSP) of Ascaris suum - evidence for two manganese binding sites and the possible role of divalent cations in filament formation. (1998) (15)
- The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities (2019) (15)
- Physical Studies on DNA From “Primitive” Eucaryote (1976) (15)
- A simple quantitative technique for testing behavioral responses of Schistosoma mansoni miracidia to chemicals. (1978) (15)
- Epigenetic regulation of RTK signaling (2017) (15)
- Acting like Actin (2000) (15)
- Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. (1992) (14)
- Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP (2016) (14)
- Reconstitution of Amoeboid Motility In Vitro Identifies a Motor-Independent Mechanism for Cell Body Retraction (2011) (14)
- A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. (1986) (13)
- New crystal forms of the motile major sperm protein (MSP) of Ascaris suum. (1996) (13)
- Effector mechanism in the response of Schistosoma mansoni miracidia to snail-conditioned water. (1980) (13)
- Constitutive cellular expression of PI 3-kinase is distinct from transient expression. (2000) (13)
- Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection. (1992) (12)
- 3 – Sperm Motility in Nematodes: Crawling Movement without Actin (1989) (12)
- Pairing between adults of Nippostrongylus brasiliensis and other species of nematodes in vitro. (1977) (12)
- Caenorhabditis elegans spermatozoa assemble membrane proteins onto the surface at the tips of pseudopodial projections. (1987) (12)
- Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer. (2018) (12)
- Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck. (1991) (11)
- Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer. (2010) (11)
- Tyrosine phosphorylation in signal transduction. (1988) (11)
- Simian Virus 40 Large Tumor Antigen Modulates the Raf Signaling Pathway* (2001) (11)
- A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells (2018) (11)
- Polyomavirus Small tAntigen: Overproduction inBacteria, Purification, andUtilization forMonoclonal andPolyclonal Antibody Production (1986) (11)
- Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris. (2005) (11)
- Crystallization of the motile major sperm protein (MSP) of the nematode Ascaris suum. (1993) (11)
- Transgenic Expression of Polyomavirus Middle T Antigen in the Mouse Prostate Gives Rise to Carcinoma (2011) (10)
- A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site (2003) (10)
- Combined inhibition of PI 3 K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK 3 CA genes (2017) (10)
- PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition (2020) (9)
- Generation of a large library of point mutations in polyoma middle T antigen. (1991) (9)
- Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. (2007) (8)
- RNAi-Based Approaches for Pancreatic Cancer Therapy (2021) (8)
- Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss (2020) (8)
- Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas (2020) (8)
- Mapping of polyomavirus middle T domain that is responsible for AP-1 activation (1998) (7)
- The Phosphatidylinositol 3-Kinase (PI3K) Isoform Dependence of Tumor Formation Is Determined by the Genetic Mode of PI3K Pathway Activation Rather than by Tissue Type (2014) (7)
- Oncogenes and Phosphatidylinositol Turnover a (1986) (7)
- Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner (2020) (7)
- Oncogenes and phosphatidylinositol turnover. (1986) (7)
- Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. (1999) (6)
- Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation (2020) (6)
- Human Tumor Mutants in PI3K p110α Subunit (2006) (6)
- Combination inhibition of PI 3 K and mTORC 1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER 2-positive breast cancer brain metastases (2016) (6)
- Corrigendum: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis (2016) (6)
- KRAS and YAP 1 Converge to Regulate EMT and Tumor Survival Citation (2014) (6)
- Relationship between plasma membrane mobility and substrate attachment in the crawling movement of spermatozoa from Caenorhabditis elegans. (1988) (6)
- Large-scale production of polyoma middle T antigen by using genetically engineered tumors (1985) (5)
- Multi-targeting siRNA nanoparticles for simultaneous inhibition of PI3K and Rac1 in PTEN-deficient prostate cancer (2021) (5)
- Physical studies on DNA from "primitive" eucaryotes. (1975) (5)
- Posttranslational insertion of a membrane protein on Caenorhabditis elegans sperm occurs without De Novo protein synthesis (1989) (5)
- Expression of influenza hemagglutinin-polyoma T-antigen fusion proteins in a rat embryo fibroblast cell line. (1987) (5)
- Amoeboid motility without actin: insights into the molecular mechanism of locomotion using the major sperm protein (MSP) of nematodes. (1998) (5)
- Molecular profiling establishes genetic features predictive of the efficacy of the p110β inhibitor KIN-193. (2019) (5)
- Differentiation of myeloid cells is accompanied by increased levels of pp 6 Oc-src protein and kinase activity ( myeloid leukemia / bone marrow / tumor promoter / cellular oncogene ) (5)
- Mechanism of activation of complexed pp60c-src by the middle T antigen of polyomavirus. (1989) (4)
- Role of the autophosphorylation site on the biological function of pp56lck. (1995) (4)
- Tyrosine kinase specific motif at subdomain VIII does not confer specificity for tyrosine. (1994) (4)
- Phosphoinositide kinase activity and transformation. (1986) (3)
- Targeted Profiling of RNA Translation (2018) (3)
- Isolation and characterization of 30-nm protein particles present in pseudopods of the amoeboid sperm of Ascaris suum. (1995) (3)
- Anti‐Rh33, the second separable example, also made by a person who made anti‐D and has C+ red cells (1986) (3)
- The catalytic domain of pp56(lck), but not its regulatory domain, is sufficient for inducing IL-2 production. (1996) (3)
- Localization oftheSimian Virus 40Small tAntigen intheNucleus andCytoplasm ofMonkeyandMouseCells (1984) (3)
- Transformation Changes the Functional Expression of Calcium Channels in Fibroblasts (1989) (3)
- Polyoma Small T Antigen Interacts with YES-Associated Protein ( YAP ) to Regulate Cell 1 Survival and Differentiation 2 3 (2014) (2)
- A strategy for screening anti‐tumor drugs utilizing oncogenes encoded in retroviral vectors (1996) (2)
- A technique for expressing eukaryotic genes in bacteria. 1980. (1992) (2)
- The cytokine-activated tyrosine kinase JAK 2 activates Raf-1 in a p 21 ras-dependent manner ( signal transduction / baculovirus / mammalian cells / oncogenes ) (2005) (2)
- Erythropoietin Activates Raf 1 by an Shc-Independent Pathway in CTLL-EPOR Cells (1997) (2)
- NTRK 2 activation cooperates with PTEN de fi ciency in TALL through activation of both the PI 3 K – AKT and JAK – STAT 3 pathways (2016) (2)
- The role of the PIK3CA gene in the development and aging of the brain (2021) (2)
- PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals (2022) (2)
- Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI (2021) (2)
- The Mediator captures CDK7, an attractive transcriptional target in cancer. (2021) (2)
- Directed membrane flow on the pseudopods of Caenorhabditis elegans spermatozoa. (1982) (2)
- Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. (2022) (2)
- S02.4 Autophagy and Protein Homeostasis S02.4–1 Protein folding stress in neurodegenerative disease: an interplay between ER stress and autophagy (2012) (2)
- C. elegans major sperm protein (2002) (1)
- Dihydropyridine-Sensitive and -Insensitive Ca2+ Channels in Normal and Transformed Fibroblasts (1988) (1)
- Major Sperm Protein and Sperm Locomotion (2013) (1)
- Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB2 receptor ( trosine kinases / oncogencs / phophorylation / breast neopsims ) (1)
- A partial genomic DNA clone for the a subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1 ( oligonucleotide probes / macrophage / y interferon-stimulated premyelocyte maturatlon / mRNA / celi adhesion molecule LFA-1 ) (1)
- Phosphatidylinositol kinases and cell transformation. (1986) (1)
- Human Prostate Epithelial Cells Androgen-Induced Differentiation and Tumorigenicity of Updated (2004) (1)
- How the phage lambda repressor and cro work (1980) (0)
- The Tyrosine Kinases pp561ck and pp59fyn are Activated in Thymocytes Undergoing Positive Selection (1993) (0)
- Extracellular | Major Sperm Protein and Sperm Locomotion (2021) (0)
- Abstract IA18: The PI3K isoforms in myeloid leukemia and hematopoietic stem cells (2020) (0)
- Cryo-Electron Microscopy, Tomography, and Single-Particle Analysis of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum (2011) (0)
- Corrigendum to “Multi-targeting siRNA nanoparticles for simultaneous inhibition of PI3K and Rac1 in PTEN-deficient prostate cancer” [J. Ind. Eng. Chem. 99 (2021) 196–203] (2021) (0)
- Synthesis ofsimian virus 40tantigen inEscherichia coli (recombinant plasmid/hybrid ribosome binding site/eukaryotic geneexpression/amino acid sequence analysis) (1979) (0)
- Lessons in signal transduction from a DNA tumor virus (1995) (0)
- Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function (cid:1) (2011) (0)
- Abstract NTOC-112: GENOMIC SCARS AND CLINICAL RESPONSE TO COMBINATION THERAPY OF PARP AND ANGIOGENESIS INHIBITORS IN OVARIAN CANCER (2017) (0)
- The p110α Catalytic Isoform of PI3 Kinase Is Important for Erythropoiesis, but Has a Minimal Role in Hematopoietic Stem Cell Self-Renewal. (2009) (0)
- Purification and biochemical characterization of non-myristoylated recombinant pp 6 Oc-src kinase (2005) (0)
- Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists (2021) (0)
- Crystal structure of the nematode sperm cell motility protein MFP2B (2005) (0)
- Both p 2 lras and pp 6 Ov-src are required , but neither alone is sufficient , to activate the Raf-1 kinase ( signal transduction / baculovirus / oncogenes / protein serine / threonine kinase / phosphorylation ) (0)
- Preparation of Colloidal Gold Particle-Monoclonal Antibody ( CGP-AB Y ) Conjugates (2003) (0)
- Mechanism of MSP-based Cell Body Retraction in the Amoeboid Sperm of Nematodes (2009) (0)
- More than one route to render tumors resistant to cGAS/STING activation. (2022) (0)
- MAJOR SPERM PROTEIN, ALPHA ISOFORM (RECOMBINANT), PH 4.6 (1996) (0)
- 3N1434 Simultaneous reconstitution of MSP-based protrusion and retraction in the amoeboid sperm of Ascaris(Cell biology6,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
- The role of the PIK3CA gene in the development and aging of the brain (2021) (0)
- Patents and literature (1983) (0)
- Abstract B31: Single-cell multiplex immunofluorescence of formalin-fixed, paraffin-embedded prostate cancer tissue identifies PI3K pathway activation in two prospective cohort studies (2020) (0)
- Abnormal development c lymphocytes in Atm mut (2016) (0)
- 2PS020 1YS0945 Simultaneous reconstitution of MSP-based protrusion and retraction in the amoeboid sperm of Ascaris(The 50th Annual Meeting of the Biophysical Society of Japan,Early Research in Biophysics Award Candidate Presentations,Early Research in Biophysics Award) (2012) (0)
- Electron Tomography of MSP Filaments Derived from the Amoeboid Sperm of Ascaris Suum (2012) (0)
- The role of PI3K-p110α in breast cancer (2005) (0)
- The p110alpha and p110delta Isoforms of PI3 Kinase Are Dispensable for Hematopoietic Stem Cell Self-Renewal but Have Redundant Roles in B Cell Differentiation. (2012) (0)
- Correction for Hwang et al., Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation (2015) (0)
- Expression of SV40 and polyoma T antigens in E. coli. (1983) (0)
- Abstract B04: CDK4/6 inhibition triggers an antitumor immune response (2018) (0)
- PI 3 K alpha and delta promote hematopoietic stem cell activation (2019) (0)
- MOTILE MAJOR SPERM PROTEIN (MSP) OF ASCARIS SUUM, NMR, 20 STRUCTURES (1999) (0)
- Unglycosylated human fibroblast interferon and a method for manufacturing the same (1981) (0)
- D83R mutant of Asaris suum major sperm protein (MSP) (2006) (0)
- optimal production of polypeptides (1981) (0)
- Epigenetic regulation of RTK signaling (2017) (0)
- Revised : 8 / 8 / 04 1 MSP dynamics drives nematode sperm locomotion (2004) (0)
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What Schools Are Affiliated With Thomas M. Roberts?
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