Thomas A. Wynn | Academic Influence

Thomas A. Wynn's AcademicInfluence.com Rankings

Thomas A. Wynn

Anthropology

#631

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#871

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anthropology Degrees

Thomas A. Wynn

Psychology

#1607

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#1929

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Cognitive Science

#63

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#64

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psychology Degrees

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Anthropology
Psychology

Thomas A. Wynn's Degrees

PhD Cognitive Science University of California, Berkeley
Masters Psychology Stanford University
Bachelors Anthropology University of California, Berkeley

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Why Is Thomas A. Wynn Influential?

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According to Wikipedia, Thomas A Wynn is an immunologist specializing in macrophage-mediated fibrosis in helminth infections. He received a PhD in the department of microbiology and immunology at the University of Wisconsin-Madison Medical School He then did post-doctoral work with Dr. Alan Sher in the laboratory of parasitic diseases at the National Institute of Allergy and Infectious Diseases. He is now a senior investigator in NIAID.

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Thomas A. Wynn's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Protective and pathogenic functions of macrophage subsets (2011) (4133)
Macrophage activation and polarization: nomenclature and experimental guidelines. (2014) (4128)
Macrophage biology in development, homeostasis and disease (2013) (3271)
Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012) (2405)
Macrophages in Tissue Repair, Regeneration, and Fibrosis. (2016) (2124)
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. (2007) (1321)
Fibrotic disease and the TH1/TH2 paradigm (2004) (1268)
Macrophages: master regulators of inflammation and fibrosis. (2010) (1119)
Integrating mechanisms of pulmonary fibrosis (2011) (1008)
IL-13 effector functions. (2003) (956)
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011) (918)
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. (1993) (873)
Fibrotic disease and the T(H)1/T(H)2 paradigm. (2004) (822)
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis (2009) (724)
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. (1999) (640)
Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection (2007) (635)
The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure (2001) (623)
Pulmonary fibrosis: pathogenesis, etiology and regulation (2009) (619)
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010) (608)
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens (2008) (594)
Inflammation and metabolism in tissue repair and regeneration (2017) (588)
Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l-Arginine Metabolism1 (2001) (579)
Type 2 immunity in tissue repair and fibrosis (2017) (539)
Type 2 cytokines: mechanisms and therapeutic strategies (2015) (494)
Host responses in tissue repair and fibrosis. (2013) (493)
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. (1993) (490)
Obstacles and opportunities for understanding macrophage polarization (2011) (489)
IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis (2000) (481)
Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1 (1997) (472)
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. (1996) (450)
IMMUNOPATHOLOGY OF SCHISTOSOMIASIS (1987) (443)
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection (1995) (436)
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. (2003) (407)
Fibrosis: from mechanisms to medicines (2020) (400)
The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells (2004) (396)
Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. (1993) (395)
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. (1994) (393)
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths (2013) (387)
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. (1993) (371)
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. (1993) (368)
Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity (2014) (367)
Mechanisms of Organ Injury and Repair by Macrophages. (2017) (360)
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma (2015) (357)
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent (2004) (356)
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. (1992) (353)
Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. (1993) (347)
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. (2006) (341)
Immunopathogenesis of schistosomiasis (2004) (318)
Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production1 (2001) (311)
Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens (2011) (302)
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology (1994) (300)
Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. (1994) (289)
Cytokine mediated tissue fibrosis. (2013) (288)
High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID) (2005) (281)
Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response (2003) (269)
Muc5ac: a critical component mediating the rejection of enteric nematodes (2011) (257)
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. (1999) (254)
Regulation of pathogenesis and immunity in helminth infections (2009) (242)
Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses (1996) (240)
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. (2011) (232)
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity (2009) (227)
NK Cell-Derived IFN-γ Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis (2006) (224)
IL-10 Is Critical for Host Resistance and Survival During Gastrointestinal Helminth Infection (2002) (220)
Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. (1994) (213)
IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. (1998) (210)
CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling (1998) (205)
An essential role for the Th2-type response in limiting tissue damage during helminth infection (2011) (203)
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity (2015) (201)
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. (2014) (193)
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. (2008) (192)
Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice (2004) (190)
Cytokine regulation of granuloma formation in schistosomiasis. (1995) (185)
Interleukin-5 (IL-5) Augments the Progression of Liver Fibrosis by Regulating IL-13 Activity (2006) (184)
Studies of murine schistosomiasis reveal interleukin‐13 blockade as a treatment for established and progressive liver fibrosis (2001) (182)
Bisalt ether electrolytes: a pathway towards lithium metal batteries with Ni-rich cathodes (2019) (179)
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids (2017) (178)
Schistosoma mansoni infection in eosinophil lineage-ablated mice. (2006) (175)
Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture (2014) (175)
Global Gene Expression Profiles During Acute Pathogen-Induced Pulmonary Inflammation Reveal Divergent Roles for Th1 and Th2 Responses in Tissue Repair1 (2003) (171)
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain (2008) (170)
The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation1 (2009) (155)
Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms. (1999) (154)
Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation (2001) (151)
Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. (1999) (151)
Macrophage activation governs schistosomiasis‐induced inflammation and fibrosis (2011) (150)
IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma. (1995) (150)
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. (1997) (149)
The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections. (1999) (149)
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. (2004) (143)
Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis (2010) (142)
Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. (1996) (140)
IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. (1995) (139)
Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase (2011) (138)
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis (2016) (137)
NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. (2000) (135)
Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. (1995) (135)
Interface-driven microstructure development and ultra high strength of bulk nanostructured Cu-Nb multilayers fabricated by severe plastic deformation (2013) (133)
Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology. (2002) (132)
IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. (1994) (130)
Faculty Opinions recommendation of Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. (2009) (130)
Cytokine production in acute versus chronic human Schistosomiasis mansoni: the cross-regulatory role of interferon-gamma and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. (1999) (128)
Immunopathology of schistosomiasis mansoni in mice and men. (2000) (128)
IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. (1996) (127)
Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases (2001) (126)
Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. (1994) (126)
Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies? (2006) (126)
Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections (2010) (125)
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. (2007) (121)
Structure of the catalytic domain of human polo-like kinase 1. (2007) (121)
Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide. (1994) (116)
Granulomas in schistosome and mycobacterial infections: a model of local immune responses. (2003) (115)
Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells1 (2008) (114)
Critical Role of IL-25 in Nematode Infection-Induced Alterations in Intestinal Function (2010) (113)
Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity (2013) (111)
TH-17: a giant step from TH1 and TH2 (2005) (109)
Inhibition of T helper 2‐type responses, IgE production and eosinophilia by synthetic lipopeptides (2003) (107)
The TNF-Family Cytokine TL1A Promotes Allergic Immunopathology through Group 2 Innate Lymphoid Cells (2013) (107)
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation (2010) (107)
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type‐1 and type‐2 cytokine‐mediated inflammatory reactions (2001) (105)
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo (2012) (103)
Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. (1994) (103)
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis (2015) (103)
T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses (2007) (102)
Opposing roles for IL‐13 and IL‐13 receptor α2 in health and disease (2004) (98)
Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to Streptococcus pneumoniae (2002) (95)
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. (2010) (94)
Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis (2014) (94)
miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Schistosome and Leishmania-associated Inflammation (2013) (91)
Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β (2017) (90)
Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. (2011) (88)
T(H)-17: a giant step from T(H)1 and T(H)2. (2005) (88)
Quantitative assessment of macrophage functions in repair and fibrosis. (2011) (86)
Transforming Growth Factor-&bgr; Signaling Promotes Pulmonary Hypertension Caused by Schistosoma Mansoni (2013) (86)
NO as an effector molecule of parasite killing: modulation of its synthesis by cytokines. (1994) (85)
Local structure adaptability through multi cations for oxygen redox accommodation in Li-Rich layered oxides (2020) (83)
IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12. (1998) (82)
Cryogenic Focused Ion Beam Characterization of Lithium Metal Anodes (2019) (81)
Egg Laying Is Delayed but Worm Fecundity Is Normal in SCID Mice Infected with Schistosoma japonicum andS. mansoni with or without Recombinant Tumor Necrosis Factor Alpha Treatment (1999) (77)
Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity (2008) (76)
Inducible Nitric Oxide Synthase-Deficient Mice Develop Enhanced Type 1 Cytokine-Associated Cellular and Humoral Immune Responses after Vaccination with AttenuatedSchistosoma mansoni Cercariae but Display Partially Reduced Resistance (1998) (76)
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation. (2016) (76)
Fc epsilonRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology. (1997) (75)
Revealing Nanoscale Solid-Solid Interfacial Phenomena for Long-Life and High-Energy All-Solid-State Batteries. (2019) (75)
IL-10 Blocks the Development of Resistance to Re-Infection with Schistosoma mansoni (2011) (73)
Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. (2016) (71)
Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation (2013) (71)
Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2? (2000) (70)
Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia (2014) (67)
IL-10 and TGF-β Control the Establishment of Persistent and Transmissible Infections Produced by Leishmania tropica in C57BL/6 Mice (2008) (63)
Interleukin-10 (IL-10) Counterregulates IL-4-Dependent Effector Mechanisms in Murine Filariasis (2004) (63)
Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. (2004) (62)
Resistance of C57BL/6 Mice to Amoebiasis Is Mediated by Nonhemopoietic Cells but Requires Hemopoietic IL-10 Production1 (2006) (62)
CpG Oligonucleotides Can Prophylactically Immunize Against Th2-Mediated Schistosome Egg-Induced Pathology by an IL-12-Independent Mechanism1 (2000) (61)
Chitinase Dependent Control of Protozoan Cyst Burden in the Brain (2012) (61)
Fibrosis under arrest (2010) (60)
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. (2011) (60)
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization. (2012) (60)
Regulation of Helminth-Induced Th2 Responses by Thymic Stromal Lymphopoietin1 (2009) (60)
Processing Parameter Influence on Texture and Microstructural Evolution in Cu-Nb Multilayer Composites Fabricated via Accumulative Roll Bonding (2014) (59)
Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2. (2011) (58)
Identification and characterization of a new gene family induced during macrophage activation. (1991) (57)
Basophils trump dendritic cells as APCs for TH2 responses (2009) (56)
Origins and Hallmarks of Macrophages: Development, Homeostasis, and Disease (2013) (56)
Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016. (2017) (54)
Functional Importance of Regional Differences in Localized Gene Expression of Receptors for IL-13 in Murine Gut1 (2006) (54)
IL-13 is a therapeutic target in radiation lung injury (2016) (53)
Correction tp Macrophage activation and polarization: Nomenclature and experimental guidelines [Immunity, 41, 2014 (14-20)] (2014) (51)
Acidic chitinase primes the protective immune response to gastrointestinal nematodes (2016) (50)
Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids (2020) (50)
Patterns of Chemokine Expression in Models of Schistosoma mansoni Inflammation and Infection Reveal Relationships between Type 1 and Type 2 Responses and Chemokines In Vivo (2001) (50)
Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions (2021) (48)
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. (2013) (48)
A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity (2013) (47)
IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation (2016) (46)
Enhanced protection from fibrosis and inflammation in the combined absence of IL‐13 and IFN‐γ (2016) (44)
Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice. (1998) (44)
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions* (2016) (44)
Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection (2018) (44)
P‐selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon γ and the IL‐13 decoy receptor (2004) (42)
Exploiting worm and allergy models to understand Th2 cytokine biology (2005) (42)
Differences in Expression, Affinity, and Function of Soluble (s)IL-4Rα and sIL-13Rα2 Suggest Opposite Effects on Allergic Responses1 (2007) (39)
IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. (2013) (39)
The p47phox−/− Mouse Model of Chronic Granulomatous Disease Has Normal Granuloma Formation and Cytokine Responses to Mycobacterium avium and Schistosoma mansoni Eggs (1999) (39)
Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. (2004) (39)
Blood Fluke Exploitation of Non-Cognate CD4+ T Cell Help to Facilitate Parasite Development (2010) (38)
Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice (1995) (38)
IL-13 Receptor α2 Regulates the Immune and Functional Response to Nippostrongylus brasiliensis Infection12 (2009) (37)
Transforming growth factor‐β1 inhibits activation of macrophage cell line RAW 264.7 for cell killing (1990) (37)
RGS16 Attenuates Pulmonary Th2/Th17 Inflammatory Responses (2012) (34)
A wedge-mounting technique for nanoscale electron backscatter diffraction (2013) (33)
The guanine protein coupled receptor rhodopsin is developmentally regulated in the free-living stages of Schistosoma mansoni. (2001) (32)
Plasminogen activator inhibitor‐2 (PAI‐2) in eosinophilic leukocytes (2004) (31)
Myeloid-cell differentiation redefined in cancer (2013) (30)
IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. (2008) (29)
Metastability and Reversibility of Anionic Redox-Based Cathode for High-Energy Rechargeable Batteries (2020) (29)
IL-25 or IL-17E Protects against High-Fat Diet–Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6 (2015) (28)
Faculty Opinions recommendation of Cutting edge: Th2 response induction by dendritic cells: a role for CD40. (2002) (28)
Schistosoma mansoni: unisexual infections sensitize mice for granuloma formation around intravenously injected eggs (1996) (27)
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. (2011) (27)
Chronic graft-versus-host disease: how can we release Prometheus? (2008) (26)
Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses. (2007) (26)
An IL‐12‐Based Vaccine Approach for Preventing Immunopathology in Schistosomiasis (1996) (26)
Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis. (2017) (25)
Amorphous Lithium Lanthanum Titanate for Solid-State Microbatteries (2017) (25)
TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction. (2014) (23)
Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells (2017) (22)
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. (2012) (21)
Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease (2019) (21)
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni. (1998) (21)
TNF-α differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines (1992) (21)
Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology. (1999) (19)
Advanced Characterization Techniques for Overcoming Challenges of Perovskite Solar Cell Materials (2020) (18)
Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice (2014) (18)
Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance (2016) (18)
Linked in vivo expression of soluble interleukin‐4 receptor and interleukin‐4 in murine schistosomiasis (1995) (18)
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. (2009) (17)
Differences in expression, affinity, and function of soluble (s)IL-4Rα and sIL-13Rα2 suggest opposite effects on allergic responses. (2008) (16)
Development of an Antipathology Vaccine for Schistosomiasis (1996) (16)
Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming (2020) (15)
Large strain deformation of bimodal layer thickness Cu/Nb nanolamellar composites (2013) (15)
Cytokines as determinants of disease and disease interactions. (1998) (14)
Fibroblast‐specific integrin‐alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis (2019) (12)
Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo (2004) (12)
IFN-γ, IL-12, and TNF-α Are Required to Maintain Reduced Liver Pathology in Mice Vaccinated with Schistosoma mansoni Eggs and IL-12 (1998) (12)
Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation (2019) (12)
Failure of P strain mice to respond to vaccination against schistosomiasis correlates with impaired production of IL‐12 and up‐regulation of Th2 cytokines that inhibit macrophage activation (1998) (12)
Studies on the production and regulation of interleukin, IL-13, IL-4 and interferon-gamma in human Schistosomiasis mansoni. (2002) (11)
(Invited) Mitigating Oxygen Release in Anionic-Redox-Active Cathode Materials By Cationic Substitution through Rational Design (2018) (11)
Interleukin‐5 does not influence differential transcription of transmembrane and soluble isoforms of IL‐5Rα in vivo (2006) (11)
IL-13 and TGF-β1: Core Mediators of Fibrosis (2015) (11)
Tailoring Spin Textures in Complex Oxide Micromagnets. (2016) (10)
The debate over the effector function of eosinophils in helminth infection: new evidence from studies on the regulation of vaccine immunity by IL-12. (1997) (10)
Faculty Opinions recommendation of Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni. (2009) (10)
In situ and operando probing of solid–solid interfaces in electrochemical devices (2018) (10)
Mapping mouse IL‐13 binding regions using structure modeling, molecular docking, and high‐density peptide microarray analysis (2011) (9)
Nanostructured complex oxides as a route towards thermal behavior in artificial spin ice systems (2017) (9)
Shedding LIGHT on severe asthma (2011) (8)
Structure and mechanical properties of swift heavy ion irradiated tungsten-bearing delta-phase oxides Y6W1O12 and Yb6W1O12 (2012) (8)
Schistosomiasis Lethal Immunopathology in Murine Cytokine Responses Induce Distinct Forms of Polarization : Excessive Type 1 and Type 2 IL-10 and the Dangers of Immune (2000) (8)
Focused Ion Beam Fabrication of LiPON-based Solid-state Lithium-ion Nanobatteries for In Situ Testing (2018) (8)
Two types of fibroblast drive arthritis (2019) (8)
Local structure of glassy lithium phosphorus oxynitride thin films: a combined experimental and ab initio approach. (2020) (8)
Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma. (2017) (7)
TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines. (1992) (6)
Depletion Regulates Nitric Oxide Production Cutting Edge: Stat6-Dependent Substrate (2001) (6)
Faculty Opinions recommendation of MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. (2009) (6)
Microcantilever bend testing and finite element simulations of HIP-ed interface-free bulk Al and Al–Al HIP bonded interfaces (2013) (5)
Enhanced Interleukin-12 and CD40 Ligand Activities but Reduced Staphylococcus aureus Cowan 1-Induced Responses Suggest a Generalized and Progressively Impaired Type 1 Cytokine Pattern for Human Schistosomiasis (2002) (5)
Slip casting of sol–gel-synthesized barium strontium zirconium titanate ceramics (2013) (4)
IL12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes. (1995) (4)
Temperature dependence of ferromagnet-antiferromagnet spin alignment and coercivity in epitaxial micromagnet bilayers (2017) (4)
Explorer Evolution of Th 2 immunity : a rapid repair response to tissue destructive pathogens (2016) (4)
Nanomechanical Behavior of U-10 Mo / Zr / Al Fuel Assemblies (2011) (3)
Regulatory and immunopathological roles of IL4 in experimental schistosomiasis. (1993) (3)
Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis (2022) (3)
Opinion on Immune Tolerance Therapeutic Development (2020) (3)
Infection Survival During Gastrointestinal Helminth IL-10 Is Critical for Host Resistance and (2002) (2)
O028 : Cross-talk between IL13 and Hedgehog pathways contributes to schistosomiasis mansoni fibrosis (2015) (2)
Global Gene Expression Profiles During Acute Pathogen-Induced Pulmonary Inflammation Reveal Divergent Roles for Th 1 and Th 2 Responses in Tissue Repair 1 (2003) (2)
Immune Down-Modulation of Chronic Disease But Is Not Required for Schistosomiasis mansoni IL-10 Regulates Liver Pathology in Acute Murine (1998) (2)
Molecular Magnetic Resonance Imaging of Liver Fibrosis and Fibrogenesis Is Not Altered by Inflammation. (2020) (2)
Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice (2014) (2)
Hsp70 Is a Positive Regulator of Airway Inflammation and Mucus Hypersecretion Through the Increase of Type 2 Cytokine Production by Activated T Cells in Allergic Asthma (2019) (2)
Experimental Models for the Analysis of IL-10 Function (2006) (2)
Understanding the deformation behavior in accumulative roll bonded Cu/Nb namolamellar multilayers via texture evolution (2011) (1)
Abstract A112: Drug discovery efforts on the RNA protein methyltransferase METTL3/METTL14 (2019) (1)
Preliminary results on the regulatory role of IFN-gamma and IL-10 human schistosomiasis mansoni. (1998) (1)
Tu1723 TNFA and IL-17 Synergize to Inhibit IL-13 Bioactivity via IL-13Ra2 Induction in Human Colonic Fibroblasts (2014) (1)
Lamination of magnesium oxide spacers to barium strontium zirconium titanate ceramics (2014) (1)
Response to Doenhoff: Granulomas: these gizmos are cool! (2003) (1)
PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS An efferocytosis-induced , IL-4 – dependent macrophage-iNKT cell circuit suppresses sterile in fl ammation and is defective in murine CGD (2013) (1)
Pathology and Pathogenesis of Parasitic Disease (2002) (1)
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor a required as a costimulatory factor for interferon v-induced activation (1)
Physiologic and Pathologic Analysis of a Murine Model of Schistosomiasis Pulmonary Vascular Remodeling. (2009) (1)
Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure. (2015) (1)
Interactions between fibroblasts , macrophages , Th 2 and Th 17 immunity regulate fibrosis 1 2 (2011) (1)
Faculty Opinions recommendation of IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. (2011) (1)
Immunity to the enteric nematode Trichuris muris is dependent on the Muc5ac mucin (2010) (1)
Infection-Induced Alterations in Intestinal Critical Role of IL-25 in Nematode (2010) (1)
Novel Role of Macrophage in the Induction of TH2 Immunity (2011) (0)
The TL1A-IL13 axis: a novel pathway for Type 2 immunity mediated by innate lymphocytes independent of helminth infection (P6264) (2013) (0)
Computationally Driven Oxygen Stabilization By Cation Substitution in Lithium-Rich Cathode Material (2017) (0)
Faculty Opinions recommendation of The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. (2004) (0)
Faculty Opinions recommendation of Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. (2007) (0)
Differential regulation of NO Synthase-2 and Arginase-1 by Type1/Type2 cytokines controls pathology in murine schistosomiasis (2002) (0)
IL-13R{alpha}2 and IL-10 coordinately suppress Th2-dependent Inflammation and Immunopathology. (2008) (0)
Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease (2019) (0)
Inflammatory Responses RGS16 Attenuates Pulmonary Th2/Th17 (0)
Faculty Opinions recommendation of Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. (2013) (0)
Dissecting “Alternative Macrophage Activation”: The role of l-arginine metabolism in chronic inflammation and fibrosis (2009) (0)
Anisotropy and micromagnetics in complex oxide thin films (2015) (0)
Graft-versus-Host Disease : The Pesky Fly in the Ointment (2007) (0)
Two types of fibroblast drive arthritis (2019) (0)
Preliminary Results on the Effects of CD 40 / CD 40 L Interactions and SAC-induction on IFN-γ Expression in Human Schistosomiasis (0)
Augmented Th2 response and liver fibrosis in mice lacking the chitinase like protein, BRP-39 (58.9) (2011) (0)
CD103-expressing CD4+Foxp3+ regulatory T cells are critical for the survival of mice infected with the helminth parasite Schistosoma mansoni. (46.17) (2007) (0)
Mycobacterium tuberculosis with Response in T Cell-Deficient Hosts Infected Regulates Innate Resistance and Neutrophil Differentially γ NK Cell-Derived IFN - (2006) (0)
Tailoring Spin Textures in Patterned Perovskite Oxide Heterostructures (2017) (0)
Inflammatory and fibrotic lung diseases (WS-085) Chairpersons: Toshihiro Nukiwa, Thomas Wynn (2010) (0)
Faculty Opinions recommendation of Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. (2002) (0)
RGS16 regulation of Th2-mediated inflammatory responses (2010) (0)
The regulation of immunopathology in schistosomiasis by type 1/type 2 cytokines (1998) (0)
Faculty Opinions recommendation of Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. (2009) (0)
Looking for a characteristic interface in accumulative roll bonded Cu/Nb multilayers (2011) (0)
Schistosomiasis-Associated Experimental Pulmonary Hypertension: Role Of IL-13 And Th-2 Signaling (2010) (0)
Expression of CD103 by Foxp3+ regulatory T cells is critical for protective immune regulation in schistosomiasis (2008) (0)
Mechanisms-Dependent Effector γ Cell-and IFN-Requires the Induction of Both B mansoni Schistosoma Optimal Vaccination Against Cheever and (1998) (0)
197 Critical Role of Epithelial Cell-Derived IL-25 in Nematode Infection-Induced Changes in Intestinal Function in Mice (2010) (0)
W1696 Type-2 Il4 Receptor(IL-4r) Plays a Pivotal Role in Regulating the Hypercontractile Smooth Muscle Response to Nematode Infection (2009) (0)
Mo1698 Genetic Deletion of the IL-13 Decoy Receptor Reduces Colonic Inflammation in a Murine Model of Inflammatory Bowel Disease (2015) (0)
SHORT COMMUNICATION - Preliminary Results on the Effects of CD40/CD40L Interactions and SAC-induction on IFN-g Expression in Human Schistosomiasis (2001) (0)
Macrophages in helminth infection: effectors, regulators, and wound healers. (2009) (0)
Eggs Schistosoma mansoni Formation and IgE Responses Induced by Cell-Mediated Pulmonary Granuloma IL-13 Is a Key Regulatory Cytokine for Th2 (1998) (0)
Necrotic liver induces pyroptosis through Caspase-1 in eosinophils (2016) (0)
Macrophage/neutrophil specific Arginase‐1 is a critical survival factor and regulator of liver fibrosis during Schistosoma mansoni infection (2008) (0)
-Dependent Effector γ Cell- and IFN- mansoni Requires the Induction of Both B Optimal Vaccination Against Schistosoma (2013) (0)
Requires Hemopoietic IL-10 Production Mediated by Nonhemopoietic Cells but Resistance of C57BL/6 Mice to Amoebiasis Is (2006) (0)
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis (2023) (0)
Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis. (2001) (0)
636 Macrophages are the IL-33-Responsive Cells Pivotal to the Induction of TH2 Immunity (2012) (0)
Innate Effector and Regulatory T Cells Controlled by Cooperating IL-10-Producing The Pathogenesis of Schistosomiasis Is (2004) (0)
Heterogeneity of human intestinal intraepithelial T cells and their abnormal distribution in Crohn’s disease revealed at high resolution (2021) (0)
Mo1767 Genetic Deletion of IL-25 Increases Susceptibility to High-Fat Diet-Induced Metabolic Dysfunction in Mice (2014) (0)
Fabrication and deformation of lamellar nanocomposites under severe rolling strains (2011) (0)
Stricturing Crohn’s disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions (2023) (0)
Correction (2001) (0)
2 Suggest Opposite Effects on Allergic α and sIL-13R α Function of Soluble (s)IL-4R Differences in Expression, Affinity, and (2013) (0)
T2053 Mechanisms Involved in the Immune Regulation of Intestinal Permeability (2010) (0)
Macrophage Plasticity: Potent Inflammatory and Immunoregulatory Activities (2015) (0)
Faculty Opinions recommendation of Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. (2010) (0)
Genetic analysis of arginase 1 in Th2-dominated lung inflammation (163.12) (2011) (0)
Distinct roles for IL-13 and IL-17 in chronic inflammation and fibrosis (134.8) (2010) (0)
Integration of deformation experiments with modeling across length scales (2011) (0)
IL-21 Receptor Signaling Partially Mediates Th2-mediated Allergic Airway Responses (2008) (0)
Receptor Tyrosine Kinase Expression and Tumor Growth by the Ron Regulation of Macrophage Arginase (2011) (0)
180 : The TNF family member TL1A: A key player in type 2 immunity in both adaptive and innate lymphocytes (2013) (0)
Pathogenesis of helminth infections. (2011) (0)
Schistosoma mansoni Immunity to Contribute Equally to Vaccine-Induced Th 2-Type Cytokine and Antibody Responses Reveal That Highly Polarized Th 1-and Studies with Double Cytokine-Deficient Mice and (1999) (0)
Materials Properties and Bond Strength Measurement in Monolithic Fuel Foils (2012) (0)
Nematode infection up-regulates IL-4 and IL-13 and induces STAT6-dependent changes in gut (2016) (0)
Accelerated fibrosis in the combined absence of Interleukin‐13 regulatory molecules: IL‐13 receptor alpha 2, IL‐10 and IL‐12 (2008) (0)
Title Cryogenic Focused Ion Beam Characterization of Lithium Metal Anodes Permalink (2019) (0)
RESEARCH NOTE - Preliminary Results on the Regulatory Role of IFN-g and IL-10 Human Schistosomiasis Mansoni (1998) (0)
MetabolismIs Shaped by the Pattern of l-Arginine Cytokines In Vivo: Granulomatous Pathology Synthase-2 and Arginase-1 by Type 1/Type 2 Differential Regulation of Nitric Oxide (2001) (0)
Infection 3 Protozoal and helminth infection (SY1-5) Chairpersons: Kenji Nakanishi, Maria Yazdanbakhsh (2010) (0)
Replacement of the murine common bile duct with a bioengineered conduit incorporating primary human cholangiocyte organoids (2017) (0)
Breaking the Mold: Partnering with the National Institutes of Health Intramural Research Program to Accelerate PhD Training. (2016) (0)
Development and Novel Characterization of All-Solid-State Thin Film Batteries (2016) (0)
Thin Film Processing of Amorphous Lithium Lanthanum Titanate Based Solid-State Microbatteries (2016) (0)
IL-12-Independent Mechanism Schistosome Egg-Induced Pathology by an Immunize Against Th2-Mediated CpG Oligonucleotides Can Prophylactically (1999) (0)
Fibrosis Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary ﬁbrosis (2017) (0)
Dependent upon IL-13 Activation of STAT6 Induced Hepatic Steatosis in Mice - Diet IL-25 or IL-17E Protects against High-Fat (2015) (0)
The influence of bi-metal interfaces on deformation mechanisms in bulk nanolaminar composites (2011) (0)
Mice deficient in IL-25 are less susceptible to dextran sulfate sodium-induced colitis (P3270) (2013) (0)
Methods for the treatment and prevention of fibrosis (2006) (0)
RGS16 regulation of Th2-mediated inflammatory responses (141.9) (2010) (0)
Treatment of fibrosis meidante antagonism of IL-3 and receptor chains yl-3. (2000) (0)
Elucidating the Redox Mechanism of Battery Cathode Materials Made from Earth-Abundant Elements (2020) (0)
Sa1838 Mechanistic Studies of Type 2 Cytokine Signaling in Chronic Colitis and Colitis-Associated Cancer (2016) (0)
and Promote Host Defense in Conventional NK Cells Can Produce IL-22 (2014) (0)

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