Tim Mitchison

Q: What Schools Are Affiliated With Tim Mitchison

Tim Mitchison is affiliated with the following schools: Chiba University, University of Oxford, University of Washington, University of California, San Francisco, Hong Kong Baptist University, University of San Francisco, Harvard University

Tim Mitchison's AcademicInfluence.com Rankings

Tim Mitchison

Biology

#1230

World Rank

#2092

Historical Rank

#632

USA Rank

Biochemistry

#223

World Rank

#281

Historical Rank

#107

USA Rank

biology Degrees

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Biology

Why Is Tim Mitchison Influential?

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According to Wikipedia, Timothy John Mitchison is a cell biologist and systems biologist and Hasib Sabbagh Professor of Systems Biology at Harvard Medical School in the United States. He is known for his discovery, with Marc Kirschner, of dynamic instability in microtubules, for studies of the mechanism of cell division, and for contributions to chemical biology.

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Tim Mitchison's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Dynamic instability of microtubule growth (1984) (3061)
Microtubule polymerization dynamics. (1997) (2436)
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury (2005) (2344)
Actin-Based Cell Motility and Cell Locomotion (1996) (1592)
A chemical method for fast and sensitive detection of DNA synthesis in vivo (2008) (1569)
Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor (2003) (1352)
Beyond self-assembly: From microtubules to morphogenesis (1986) (1322)
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish (2009) (1190)
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. (1999) (1136)
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes (2011) (866)
Actin microfilament dynamics in locomoting cells (1991) (812)
Nucleation of microtubule assembly by a γ-tubulin-containing ring complex (1995) (803)
Cytoskeletal dynamics and nerve growth (1988) (793)
Microtubule assembly nucleated by isolated centrosomes (1984) (758)
A standardized kinesin nomenclature (2004) (750)
Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils (2003) (707)
Kin I Kinesins Are Microtubule-Destabilizing Enzymes (1999) (704)
Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5 (2000) (695)
Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules (1996) (661)
Mitotic spindle organization by a plus-end-directed microtubule motor (1992) (655)
Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes (1997) (616)
Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence (1989) (614)
Multidimensional Drug Profiling By Automated Microscopy (2004) (609)
Reassembly of contractile actin cortex in cell blebs (2006) (583)
Non-equilibration of hydrostatic pressure in blebbing cells (2005) (582)
XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly (1996) (543)
The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization (1992) (534)
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL (2001) (534)
Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. (1998) (534)
A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro (1994) (523)
The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly (1997) (511)
Self- and actin-templated assembly of Mammalian septins. (2002) (493)
Coupled, Circumferential Motions of the Cell Wall Synthesis Machinery and MreB Filaments in B. subtilis (2011) (489)
Animal cytokinesis: from parts list to mechanisms. (2006) (452)
Single-Molecule Speckle Analysis of Actin Filament Turnover in Lamellipodia (2002) (447)
Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro (1985) (444)
Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts (1990) (438)
Actin-Dependent Propulsion of Endosomes and Lysosomes by Recruitment of N-Wasp✪ (2000) (437)
Sites of microtubule assembly and disassembly in the mitotic spindle (1986) (424)
A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity (1998) (415)
Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction (1999) (411)
Microtubule dynamics (1986) (410)
Life and times of a cellular bleb. (2008) (404)
Polewards chromosome movement driven by microtubule depolymerization in vitro (1988) (398)
Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis (1995) (381)
Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. (1992) (367)
A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods (2004) (367)
Specificity of blebbistatin, an inhibitor of myosin II (2004) (358)
A small-molecule inhibitor of skeletal muscle myosin II (2002) (336)
Identification of Novel Graded Polarity Actin Filament Bundles in Locomoting Heart Fibroblasts: Implications for the Generation of Motile Force (1997) (332)
The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns (2013) (330)
Vertebrate Shugoshin Links Sister Centromere Cohesion and Kinetochore Microtubule Stability in Mitosis (2004) (330)
Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets (2004) (330)
Characterization of Two Related Drosophila γ-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules (1999) (326)
Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian Degeneration (2003) (325)
Integrating high-content screening and ligand-target prediction to identify mechanism of action. (2008) (323)
Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material (1983) (317)
Myosin is involved in postmitotic cell spreading (1995) (316)
A purified Drosophila septin complex forms filaments and exhibits GTPase activity (1996) (314)
Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2 (2013) (309)
Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. (1995) (309)
The Bipolar Kinesin, KLP61F, Cross-links Microtubules within Interpolar Microtubule Bundles of Drosophila Embryonic Mitotic Spindles (1999) (308)
Functional Analysis of a Human Homologue of the Drosophila Actin Binding Protein Anillin Suggests a Role in Cytokinesis (2000) (297)
The proliferation rate paradox in antimitotic chemotherapy (2012) (297)
IRF3 and Type I Interferons Fuel a Fatal Response to Myocardial Infarction (2017) (294)
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. (2009) (292)
Control of actin polymerization in live and permeabilized fibroblasts (1991) (292)
The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. (1999) (289)
Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT (2002) (288)
Mitosis: a history of division (2001) (287)
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. (2018) (287)
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. (1995) (287)
Spatial control of actin polymerization during neutrophil chemotaxis (1999) (286)
Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts (1994) (284)
Anillin binds nonmuscle myosin II and regulates the contractile ring. (2004) (281)
Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. (2002) (267)
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds (2009) (266)
Polymerization of Purified Yeast Septins: Evidence That Organized Filament Arrays May Not Be Required for Septin Function (1998) (263)
Localization of antigenic determinants in whole Drosophila embryos. (1983) (262)
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs (2014) (258)
Amyloid-like Self-Assembly of a Cellular Compartment (2016) (257)
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function (2005) (256)
Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis (1992) (252)
Force and Length in the Mitotic Spindle (2009) (246)
Actin dynamics in vivo. (1997) (246)
Influence of the centrosome on the structure of nucleated microtubules (1985) (242)
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. (2002) (242)
Properties of the kinetochore in vitro. II. Microtubule capture and ATP- dependent translocation (1985) (241)
Mitotic spindle assembly by two different pathways in vitro (1991) (240)
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. (2004) (238)
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. (2002) (236)
Structural Plasticity in Actin and Tubulin Polymer Dynamics (2009) (235)
Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. (2004) (234)
Midbody assembly and its regulation during cytokinesis (2012) (232)
Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts (1993) (231)
Determining the position of the cell division plane (2003) (228)
Poly(ADP-ribose) is required for spindle assembly and structure (2004) (226)
Xenopus Actin Depolymerizing Factor/Cofilin (XAC) Is Responsible for the Turnover of Actin Filaments in Listeria monocytogenes Tails (1997) (223)
Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. (2000) (220)
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction (2012) (213)
Two different microtubule-based motor activities with opposite polarities in kinetochores (1991) (211)
Microtubule dynamics and kinetochore function in mitosis. (1988) (206)
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. (2008) (204)
Structural insights into yeast septin organization from polarized fluorescence microscopy (2006) (204)
Evidence for an Upper Limit to Mitotic Spindle Length (2008) (202)
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. (2004) (200)
Localization of an exchangeable GTP binding site at the plus end of microtubules. (1993) (199)
The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. (1996) (199)
Behaviour of microtubules and actin filaments in living Drosophila embryos. (1988) (196)
The three faces of profilin (1993) (194)
Poleward microtubule flux mitotic spindles assembled in vitro (1991) (190)
Micron-scale coherence in interphase chromatin dynamics (2013) (185)
EB1 targets to kinetochores with attached, polymerizing microtubules. (2002) (183)
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles (2004) (181)
Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding (1985) (181)
A Model for Cleavage Plane Determination in Early Amphibian and Fish Embryos (2010) (179)
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo (2013) (175)
Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers (2008) (172)
Eg5 is static in bipolar spindles relative to tubulin (2001) (170)
Microtubule polymer assembly and transport during axonal elongation (1991) (168)
Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. (2005) (167)
Anaphase A Chromosome Movement and Poleward Spindle Microtubule Flux Occur At Similar Rates in Xenopus Extract Spindles (1998) (159)
KIF4 Regulates Midzone Length during Cytokinesis (2011) (156)
Comparison of actin and cell surface dynamics in motile fibroblasts (1992) (155)
Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. (1992) (151)
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. (2005) (150)
Polar stimulation and constrained cell migration in microfluidic channels. (2007) (149)
Slide-and-Cluster Models for Spindle Assembly (2007) (148)
Exo1: A new chemical inhibitor of the exocytic pathway (2003) (146)
XCTK2: A Kinesin-related Protein That Promotes Mitotic Spindle Assembly in Xenopus laevis Egg Extracts (1997) (146)
Towards a pharmacological genetics. (1994) (145)
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (2011) (142)
A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe (1999) (141)
Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. (2008) (139)
Rapid actin monomer–insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1 (2006) (133)
Phenotypic screening of small molecule libraries by high throughput cell imaging. (2003) (132)
Caspase-11 regulates cell migration by promoting Aip1–Cofilin-mediated actin depolymerization (2007) (132)
Molecular “Vitalism” (2000) (131)
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. (2003) (131)
A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. (2004) (129)
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. (2006) (127)
Kinesin-Related Proteins at Mitotic Spindle Poles: Function and Regulation (1996) (127)
Actin-dependent motile forces and cell motility. (1994) (126)
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles (2003) (125)
Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes (1984) (125)
Mammalian septins nomenclature. (2002) (125)
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) (125)
Poleward Microtubule Flux Is a Major Component of Spindle Dynamics and Anaphase A in Mitotic Drosophila Embryos (2002) (121)
Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. (1997) (119)
Caged fluorescent probes. (1998) (119)
Cell polarization during monopolar cytokinesis (2008) (119)
Anticancer flavonoids are mouse-selective STING agonists. (2013) (117)
Anti-Microtubule Drugs. (2016) (116)
Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells (2013) (114)
Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate (2008) (114)
XRHAMM Functions in Ran-Dependent Microtubule Nucleation and Pole Formation during Anastral Spindle Assembly (2004) (113)
Microtubule-motor activity of a yeast centromere-binding protein complex (1992) (113)
Direct observation of steady-state microtubule dynamics (1986) (113)
Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification (2003) (109)
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities (2013) (109)
Spatial organization of cytokinesis signaling reconstituted in a cell-free system (2014) (106)
Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes (1991) (106)
Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. (2011) (106)
Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. (2004) (105)
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells (2014) (102)
The Force-Velocity Relationship for the Actin-Based Motility of Listeria monocytogenes (2003) (102)
How does a millimeter-sized cell find its center? (2009) (102)
The Nuclear Proteome of a Vertebrate (2015) (102)
Actin based motility on retraction fibers in mitotic PtK2 cells. (1992) (99)
Cell cycle control of higher-order chromatin assembly around naked DNA in vitro (1991) (98)
Compression Regulates Mitotic Spindle Length by a Mechanochemical Switch at the Poles (2009) (98)
Mechanical properties of Xenopus egg cytoplasmic extracts. (2005) (97)
The first World Cell Race (2012) (95)
The SMC family: from chromosome condensation to dosage compensation. (1995) (94)
Animal cell hydraulics (2009) (94)
Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex (2004) (94)
Vimentin fibers orient traction stress (2017) (92)
Rappaport rules: cleavage furrow induction in animal cells. (1997) (91)
A Novel Action of Histone Deacetylase Inhibitors in a Protein Aggresome Disease Model (2004) (91)
A Small-Molecule Inhibitor of Mps1 Blocks the Spindle-Checkpoint Response to a Lack of Tension on Mitotic Chromosomes (2005) (89)
Deformations Within Moving Kinetochores Reveal Different Sites of Active and Passive Force Generation (2012) (89)
Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity (2009) (88)
The Microtubule-Destabilizing Kinesin XKCM1 Is Required for Chromosome Positioning during Spindle Assembly (2002) (86)
Fast Microtubule Dynamics in Meiotic Spindles Measured by Single Molecule Imaging: Evidence That the Spindle Environment Does Not Stabilize Microtubules (2010) (86)
Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis (2012) (86)
Spindle Fusion Requires Dynein-Mediated Sliding of Oppositely Oriented Microtubules (2009) (85)
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol (2006) (84)
Nonredundant Functions of Kinesin-13s during Meiotic Spindle Assembly (2007) (84)
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells (2012) (84)
Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. (2004) (83)
[26] Isolation of mammalian centrosomes (1986) (83)
Binding Partner Switching on Microtubules and Aurora-B in the Mitosis to Cytokinesis Transition* (2009) (82)
Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. (2009) (82)
Small molecule screening by imaging. (2006) (82)
Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments (2013) (81)
The Majority of the Saccharomyces cerevisiae Septin Complexes Do Not Exchange Guanine Nucleotides* (2004) (81)
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts (2013) (80)
Dynamic stabilization of actin filaments (2008) (77)
Microtubule dynamic instability (2006) (77)
Microtubule plus-end dynamics in Xenopus egg extract spindles. (2004) (75)
In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy (2015) (74)
Microtubule nucleation remote from centrosomes may explain how asters span large cells (2014) (73)
A new method reveals microtubule minus ends throughout the meiotic spindle (2006) (72)
Mitosis: basic concepts. (1989) (71)
A new role for motor proteins as couplers to depolymerizing microtubules (1995) (70)
Compare and contrast actin filaments and microtubules. (1992) (68)
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin (2014) (68)
The nucleation-release model of actin filament dynamics in cell motility. (1992) (68)
Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching (1984) (62)
The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound. (1995) (61)
Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos (2011) (61)
Stochastic Competition between Mechanistically Independent Slippage and Death Pathways Determines Cell Fate during Mitotic Arrest (2010) (60)
Modulation of microtubule stability by kinetochores in vitro (1990) (60)
Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules. (1994) (60)
Evolution of a dynamic cytoskeleton. (1995) (59)
Self-organization of polymer-motor systems in the cytoskeleton. (1992) (59)
Isolation of mammalian centrosomes. (1986) (58)
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival (2016) (57)
Noble metals strip peptides from class II MHC proteins (2006) (57)
A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly (2008) (56)
Cell biology: How cilia beat (2010) (56)
Catastrophic revelations about Op18/stathmin. (1996) (56)
Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. (2008) (55)
TTC5 mediates autoregulation of tubulin via mRNA degradation (2019) (55)
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. (2017) (54)
Allele-specific activators and inhibitors for kinesin. (1999) (54)
Mechanism and function of poleward flux in Xenopus extract meiotic spindles (2005) (53)
Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. (2004) (52)
Rapid de-localization of actin leading edge components with BDM treatment (2003) (52)
Eg5 Causes Elongation of Meiotic Spindles When Flux-Associated Microtubule Depolymerization Is Blocked (2004) (51)
Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug? (2017) (50)
High‐Content Screening and Profiling of Drug Activity in an Automated Centrosome‐Duplication Assay (2005) (47)
Directly probing the mechanical properties of the spindle and its matrix (2010) (47)
Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation (2018) (46)
Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression (2004) (46)
27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells (2017) (46)
Symmetry of septin hourglass and ring structures. (2007) (45)
Colloid osmotic parameterization and measurement of subcellular crowding (2019) (45)
Physical basis of large microtubule aster growth (2016) (45)
Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response (2016) (44)
Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers. (2012) (43)
Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues (2019) (40)
Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. (2009) (40)
Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. (2009) (40)
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. (2021) (39)
Cytoskeleton: What Does GTP Do for Septins? (2002) (39)
Tubulin flux in the mitotic spindle: where does it come from, where is it going? (1990) (38)
Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. (2015) (38)
Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis (2015) (37)
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin (2005) (36)
Selection of Genetic Agents from Random Peptide Aptamer Expression Libraries (36)
Autoregulation and repair in microtubule homeostasis. (2019) (36)
The first World Cell Race (2013) (34)
Dynamics of the mitotic spindle--potential therapeutic targets. (2003) (34)
Signal transduction: Actin, cofilin and cognition (1998) (34)
A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts. (1997) (33)
Organization of early frog embryos by chemical waves emanating from centrosomes (2014) (33)
Dynamics of microtubule assembly in vivo (1994) (33)
Xenopus egg cytoplasm with intact actin. (2014) (32)
Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol (2013) (32)
Motion pictures (2003) (32)
Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability (1987) (32)
Spatial Patterning of Metabolism by Mitochondria, Oxygen, and Energy Sinks in a Model Cytoplasm (2008) (31)
Size Scaling of Microtubule Assemblies in Early Xenopus Embryos. (2015) (31)
Purification and assay of the platelet Arp2/3 complex. (1998) (31)
Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis. (2017) (30)
[41] Purification of cytoskeletal proteins using peptide antibodies (1998) (29)
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine (2018) (29)
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation (2017) (29)
Interdisciplinary Graduate Training in Teaching Labs (2012) (28)
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells (2021) (28)
Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos. (2011) (27)
Cell biology: Powerful curves (2005) (27)
FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry (2010) (27)
A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line (2019) (27)
Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton (2012) (27)
The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos (2015) (26)
Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis (2020) (26)
Small molecules in an RNAi world. (2006) (25)
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI (2012) (24)
The balbiani body and the concept of physiological amyloids (2017) (24)
Actin-aggregating cucurbitacins from Physocarpus capitatus. (2008) (24)
Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs (2015) (23)
Tubulin and FtsZ structures: functional and therapeutic implications. (1998) (22)
Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover. (2010) (22)
Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters (2017) (22)
An Intermittent Live Cell Imaging Screen for siRNA Enhancers and Suppressors of a Kinesin-5 Inhibitor (2009) (22)
Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. (2012) (21)
Preparation and characterization of caged fluorescein tubulin. (1998) (21)
Purification of cytoskeletal proteins using peptide antibodies. (1998) (21)
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation (2021) (20)
Purification and assay of gamma tubulin ring complex. (1998) (20)
Purification and assay of a septin complex from Drosophila embryos. (1998) (20)
A decade of molecular cell biology: achievements and challenges (2011) (20)
A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts (1992) (19)
shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data (2021) (18)
Mitosis: Kinetochores pass the IQ test (1994) (18)
Microtubule assembly in meiotic extract requires glycogen (2011) (18)
Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. (2014) (17)
Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins. (2015) (17)
Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization. (2014) (17)
A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling. (2018) (17)
Mitosis: New Roles for Myosin-X and Actin at the Spindle (2008) (17)
Site occupancy calibration of taxane pharmacology in live cells and tissues (2018) (16)
Regulation of the direction of chromosome movement. (1991) (16)
The Role of Microtubule Polarity in the Movement of Kinesin and Kinetochores (1986) (16)
Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs (2019) (15)
Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density (2019) (15)
O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport (2021) (14)
Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm (2020) (13)
Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation. (2013) (13)
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor (2019) (13)
Psychosine, Cytokinesis, and Orphan Receptors (2001) (12)
Labeling Carboxyl Groups of Surface-Exposed Proteins Provides an Orthogonal Approach for Cell Surface Isolation. (2018) (12)
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs (2020) (12)
Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. (2015) (12)
Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin (2017) (12)
Cell death when the SAC is out of commission (2010) (11)
Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. (2011) (11)
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells (2020) (11)
Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts. (2016) (10)
Beyond Langmuir: surface-bound macromolecule condensates (2020) (10)
Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses (2021) (10)
Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles (2019) (10)
Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells (2014) (9)
Motoring in the spindle (1990) (9)
An efficient substitution reaction for the preparation of thyroid hormone analogues. (1998) (9)
Assembly of Spindles and Asters in Xenopus Egg Extracts. (2018) (9)
An assay for the activity of microtubule-based motors on the kinetochores of isolated Chinese hamster ovary chromosomes. (1993) (9)
Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos (2011) (9)
The Engine of Microtubule Dynamics Comes into Focus (2014) (8)
Differential Determinants of Cancer Cell Insensitivity to Antimitotic Drugs Discriminated by a One-Step Cell Imaging Assay (2013) (8)
A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs (2019) (8)
Meiotic Spindle: Sculpted by Severing (2006) (8)
Kinetochores on the move (1988) (8)
Self-Organization of Cellular Units. (2021) (8)
Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. (1999) (7)
A question of taste (2013) (7)
Photoactivation of Fluorescence as a Probe for Cytoskeletal Dynamics in Mitosis and Cell Motility (1999) (7)
The kinetochore in captivity (1990) (6)
Molecular basis of chromosome movement: Current Opinion in Structural Biology 1992, 2:275–279 (1992) (6)
Erratum: Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality (Proceedings of the National Academy of Sciences of the United States of America (August 10, 2004) 101, 32 (11821-11826)) (2004) (6)
Erratum: Corrigendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury (2005) (6)
Evidence for a role of calcium in STING signaling (2017) (6)
Erratum to ‘Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis’: [Chem. Biol. 7 (2000) 275-286] (2001) (6)
Cell Biology: a Laboratory Handbook (1994) (5)
Synthesis and Phenotypic Screening of a Guanine‐Mimetic Library (2004) (5)
Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways (2020) (5)
Blebbistatin A cell permeable inhibitor of non-muscle myosin II (2001) (5)
Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics. (2014) (5)
Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. (2016) (4)
Caged fluorescent probes for monitoring cytoskeleton dynamics (1994) (4)
Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs (2020) (4)
Probing cell division with "chemical genetics". (2002) (4)
Molecular basis of chromosome movement (1992) (3)
Microtubule dynamics in the mitotic spindle photoactivation of fluorescence reveals polewards flux during metaphase (1988) (3)
Influence of the Centrosome of Nucleated Microtubules on the Structure (1985) (3)
Pronuclear Migration: No Attachment? No Union, but a Futile Cycle! (2012) (3)
Shinya Inoué (1921–2019) (2020) (3)
4.16 Mechanical Forces in Mitosis (2012) (3)
Spatial variation of microtubule depolymerization in large asters (2021) (3)
Cell Biology: Size Scaling of Mitotic Spindles (2020) (2)
Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells (2017) (2)
Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos. (2019) (2)
Comment Psychosine , Cytokinesis , and Orphan Receptors : Unexpected Connections (2001) (2)
Mitosis. The kinetochore in captivity. (1990) (2)
Good things from slime (1987) (2)
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins (2021) (2)
Remaining Mysteries of the Cytoplasm (2010) (2)
CellCycleControlofHigher-OrderChromatin Assembly around Naked DNA InVitro (1991) (1)
Toward synthetic cells (2019) (1)
Cell biology. Motoring in the spindle. (1990) (1)
Author response: Physical basis of large microtubule aster growth (2016) (1)
ReviewForce and Length in the Mitotic Spindle (2009) (1)
Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. (2015) (1)
Psychosine, Cytokinesis, and Orphan Receptors: Unexpected Connections (2001) (1)
Spindle-to-Cortex Communication in Cleaving Frog Eggs (2017) (1)
Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin (2022) (1)
Opposite Patterns of Synchrony in Sympatric Disease Metapopulations (1999) (1)
Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline (2021) (1)
Glycogen-dependent demixing of frog egg cytoplasm at increased crowding (2021) (1)
Size scaling of microtubule asters in confinement (2016) (1)
Spring-like behavior of cytoplasm holds the mitotic spindle in place (2022) (1)
Size and Speed Go Hand in Hand in Cytokinesis (2009) (1)
O-GlcNAc modification of nuclear pore complexes accelerates bi-directional transport (2020) (1)
Advances in circuits and systems (2004) (0)
Supplementary Materials for Interdisciplinary Graduate Training in Teaching Labs (2012) (0)
ChemicalSubdomainsWithintheKinetochoreDomain ofIsolated CHO MitoticChromosomes (1991) (0)
Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion (2020) (0)
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity (2022) (0)
Mechanism and Function of Chromatin Positional Dynamics (2012) (0)
Publisher Correction: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation (2021) (0)
Crowds and power - coordinated in vitro development of a benign breast lesion (2019) (0)
CompareandContrast Actin Filaments andMicrotubules (1992) (0)
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (-)-Blebbistatin. (2005) (0)
Editorial Board (1995) (0)
Investigation oftheMechanism ofRetraction ofthe CellMarginandRearward FlowofNodules during Mitotic CellRounding (1997) (0)
A Database for Peer-Reviewed Microscopy Images and Their Unpublished Brethren (2011) (0)
Localization of C 2 CF-Tubulin to Single Microtubules (2002) (0)
Cytoskeleton: What Does GTP Do for Septins? Dispatch (2002) (0)
Separate Locations of the Active and Passive Microtubule Interfaces in Kinetochores Inferred from Direction-Dependent Structural Changes (2011) (0)
Barotaxis in a Confined Neutrophil (2014) (0)
The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos (2015) (0)
Live cell reporters reveal bidirectional acceleration of nucleocytoplasmic transport by O-GlcNAc modification of the nuclear pore complex (2020) (0)
Workshops (2001) (0)
So many ways to naturally kill a cancer cell (2021) (0)
1K1020 MICROTUBULE DYNAMICS AND MOTOR PROTEINS IN MITOSIS (2009) (0)
Extracts That Enter Mitosis after Interphase ( " Interphase-to-Mitotic Extracts " (2002) (0)
Physical basis of large microtubule aster growth this access benefits you. Your story matters (2017) (0)
Abstract 234: Mitochondrial morphology as a biomarker of cancer phenotype and drug response (2016) (0)
Aurora B Kinase Dependent Phosphorylation of Keratin 8 is required for Cytokinesis in Mammalian Cells of Epithelial Origin (2023) (0)
Article Slide-and-Cluster Models for Spindle Assembly (2007) (0)
Towards an Understanding of Yeast Septins' Organization In Vivo (2005) (0)
Decoration of Actin Filaments in Postmitotic Spreading Cells (2002) (0)
Reconstitution of aster movement and cell division plane positioning in Xenopus egg extract (2018) (0)
Electron microscopy of microtubule cytoskeleton assembly in vitro. (2014) (0)
High‐Content Screening and Profiling of Drug Activity in an Automated Centrosome‐Duplication Assay (0)
Evidence thattheMIF2GeneofSaccharomyces cerevisiae Encodes aCentromere Protein with Homology totheMammalianCentromere Protein (1995) (0)
Article KIF4 Regulates Midzone Length during Cytokinesis (2011) (0)
Abstract 35: Breast cancer cell interactions (2012) (0)
Abstract 405: Innate immunity in taxol-mediated tumor regression (2012) (0)
From the archive (2018) (0)
Annual Meeting Program. (2018) (0)
So many ways to naturally kill a cancer cell (2021) (0)
Abstract A7: Investigating the differential regulation of poly(ADP-ribose) polymerases in cancer (2012) (0)
High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response (2022) (0)
Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression (2020) (0)
Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells (2021) (0)
Editorial Board (1995) (0)
Author response: shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data (2021) (0)
A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line (2019) (0)
Author response: Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm (2020) (0)
High content screening and computational prediction reveal viral genes that suppress innate immune response (2021) (0)
Biophysical and biological characterisation of blebbing (2004) (0)
Cytoplasmic Volume Modulates Spindle Size During Embryogenesis (2013) (0)
The Nuclear Proteome of a Vertebrate Graphical (2015) (0)
Actin tracks (1991) (0)
Assembly of Large Microtubule Complexes (2017) (0)
Wingless virgin queens assume helper roles in Acromyrmex leaf-cutting ants (2012) (0)
Response of the Mitotic Spindle to Mechanical Force (2009) (0)
Integration of Image-Based Cytological Phenotypes with Computational Ligand-Target Prediction to Identify Mechanisms of Action (2008) (0)
Assembly and control of large microtubule complexes (2017) (0)
Eighth European Cell Cycle Workshop (1987) (0)
Cell division. Kinetochores on the move. (1988) (0)
Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex (2019) (0)
Abstract 1021: Investigating the mechanism of PARP7 inhibition in type I interferon signaling by arrayed CRISPR screening (2021) (0)
100 and 50 years ago (1998) (0)
Human Eg5 motor domain bound to Mg-ADP and monastrol (2005) (0)
Abstract SY28-01: Is mitosis the target of “anti-mitotic” cancer drugs. (2013) (0)
Editorial Board (1995) (0)
Chapter 2 Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos (2019) (0)
ASCB 50TH ANNIVERSARY ESSAY Remaining Mysteries of the Cytoplasm (2010) (0)
Cell motility: good things from slime. (1987) (0)
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells (2020) (0)
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine (2018) (0)
Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. (2022) (0)
Watching the Motions of the Cell Wall Synthesis Machinery and Underlying Cytoskeleton in B. Subtilis (2012) (0)
Cytoskeletal Integrity IsRequired throughout the Mitogen Stimulation PhaseoftheCellCycleand Mediates theAnchorage-dependent Expression of Cyclin DI (1996) (0)
Machine characterization of rat toxin responses identifies disease states, tolerance mechanisms and organ to whole-body communication (2018) (0)
Corrigenda (1990) (0)
XCTK1: A Xenopus C-terminal Kinesin-like Protein (2002) (0)
From Mitotic Mechanism to New Cancer Drugs (2006) (0)
Abstract A297: Microtubule targeting antimitotic drugs induce a lower mitotic arrest than clinically less effective antimitotic Eg5 inhibitors in mouse xenografts. (2013) (0)
Thyroideahormonanaloger and methods for their preparation (1999) (0)

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