Timothy Hla

Q: What Schools Are Affiliated With Timothy Hla

Timothy Hla is affiliated with the following schools: George Washington University, Weill Cornell Medicine, University of California, San Diego, Cornell University, Chungbuk National University, University of California, San Francisco, Duke University, Stanford University, Georgetown University, Johns Hopkins University, Queen Mary University of London, University of Connecticut, Harvard University

Timothy Hla's AcademicInfluence.com Rankings

Timothy Hla

Philosophy

#4742

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#7368

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Logic

#2138

World Rank

#3063

Historical Rank

philosophy Degrees

Timothy Hla

Biology

#6259

World Rank

#8933

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biology Degrees

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Philosophy
Biology

Timothy Hla's Degrees

PhD Biochemistry University of California, San Francisco
Doctorate Medicine Harvard University

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Timothy Hla's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004) (1612)
Human cyclooxygenase-2 cDNA. (1992) (1449)
Expression of cyclooxygenase-1 and -2 in human colorectal cancer. (1995) (1220)
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. (2000) (1180)
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (1998) (1014)
Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate (1999) (996)
Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice* (2001) (846)
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. (1994) (684)
Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis (1995) (573)
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. (1989) (571)
Lysophospholipids--Receptor Revelations (2001) (535)
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M (2011) (515)
Regulation of PTEN by Rho small GTPases (2005) (496)
Structure of the human cyclo-oxygenase-2 gene. (1994) (496)
The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses1 (2000) (495)
Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival (1998) (487)
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. (1994) (483)
International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature (2002) (482)
Structural and functional characteristics of S1P receptors (2004) (481)
An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. (1990) (476)
FTY720: Sphingosine 1‐Phosphate Receptor‐1 in the Control of Lymphocyte Egress and Endothelial Barrier Function (2004) (462)
Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. (1990) (461)
Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2 * (1999) (461)
Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate (2008) (457)
Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. (1994) (429)
Physiological and pathological actions of sphingosine 1-phosphate. (2004) (407)
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. (2015) (398)
Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor* (2007) (390)
Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability* (2003) (384)
Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. (2004) (376)
An update on the biology of sphingosine 1-phosphate receptors (2014) (375)
15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats (2000) (372)
Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland (2011) (368)
Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins* (1999) (356)
In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. (1992) (353)
Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. (1990) (349)
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. (2002) (336)
Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8* (2000) (332)
Expression of cyclooxygenase‐2 in prostate carcinoma (2000) (330)
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. (2000) (323)
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature (2010) (319)
Induction of Vascular Permeability by the Sphingosine-1-Phosphate Receptor–2 (S1P2R) and its Downstream Effectors ROCK and PTEN (2007) (306)
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (2001) (305)
Extracellular Export of Sphingosine Kinase-1 Enzyme (2002) (286)
Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins* (2001) (284)
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. (2006) (284)
Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells* (2001) (279)
Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. (1997) (270)
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. (2004) (265)
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. (2012) (264)
Signaling and biological actions of sphingosine 1-phosphate. (2003) (263)
Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5* (1999) (262)
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism (2004) (255)
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation (2015) (247)
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy (2019) (244)
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. (2005) (239)
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation (2006) (236)
Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. (2007) (234)
Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. (1996) (231)
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. (2004) (226)
Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. (2006) (219)
Cyclooxygenase-1 and -2 isoenzymes. (1999) (216)
Sphingosine 1-phosphate signalling (2014) (214)
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis (2015) (214)
Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. (2005) (211)
Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice* (2007) (201)
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. (2011) (196)
Prostaglandins & other lipid mediators: a new phase, a new team. (2004) (193)
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. (1999) (189)
HDL-bound sphingosine 1-phosphate restrains lymphopoiesis and neuroinflammation (2015) (184)
Cyclooxygenase Gene Expression in Inflammation and Angiogenesis a (1993) (180)
The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. (2005) (180)
Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesis (2003) (180)
Sphingolipid signaling in metabolic disorders. (2012) (179)
The vascular S1P gradient-cellular sources and biological significance. (2008) (178)
The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2* (2003) (175)
Dual Roles of Tight Junction-associated Protein, Zonula Occludens-1, in Sphingosine 1-Phosphate-mediated Endothelial Chemotaxis and Barrier Integrity* (2006) (174)
Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration (2001) (173)
Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? (1999) (171)
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. (2005) (170)
Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. (2009) (169)
Sphingosine 1-phosphate receptors. (2001) (168)
The Inducible G Protein-coupled Receptor edg-1 Signals via the G/Mitogen-activated Protein Kinase Pathway (*) (1996) (168)
TWEAK Is an Endothelial Cell Growth and Chemotactic Factor That Also Potentiates FGF-2 and VEGF-A Mitogenic Activity (2003) (162)
Sphingosine 1-phosphate in coagulation and inflammation (2011) (158)
HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. (2005) (158)
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics (2010) (156)
Sphingosine 1-phosphate (S1P) (2011) (152)
Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. (2014) (149)
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. (2006) (145)
Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis (2011) (144)
Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. (2003) (142)
Defective sphingosine-1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation (2013) (142)
Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1 (2017) (141)
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. (2000) (135)
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. (2011) (134)
Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation (2009) (126)
Sphingosine 1-phosphate and inflammation. (2019) (124)
Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 Expression* (2003) (124)
Sphingosine‐1‐phosphate receptor 1 signalling in T cells: trafficking and beyond (2014) (123)
Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist* (1998) (121)
Overexpression of Cyclooxygenase-2 Induces Cell Cycle Arrest (1999) (120)
Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs. (1998) (115)
The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. (2005) (114)
S1P control of endothelial integrity. (2014) (113)
Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression* (1997) (108)
Constitutive expression of the S1P1 receptor in adult tissues. (2004) (106)
A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). (2007) (105)
HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. (2006) (103)
Regulation of vascular physiology and pathology by the S1P2 receptor subtype. (2008) (102)
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. (2001) (99)
Sphingosine 1-phosphate (2012) (95)
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells (2017) (95)
Impaired endothelial barrier function in apolipoprotein M‐deficient mice is dependent on sphingosine‐1‐phosphate receptor 1 (2016) (91)
Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor. (1985) (90)
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure (2015) (89)
Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. (2008) (88)
Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. (1993) (87)
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. (2001) (86)
Serum Withdrawal-induced Post-transcriptional Stabilization of Cyclooxygenase-2 mRNA in MDA-MB-231 Mammary Carcinoma Cells Requires the Activity of the p38 Stress-activated Protein Kinase* (2000) (86)
Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics* (2007) (85)
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice (2006) (85)
Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. (1991) (84)
Dissociation of basal turnover and cytokine-induced transcript stabilization of the human cyclooxygenase-2 mRNA by mutagenesis of the 3'-untranslated region. (1998) (82)
Prostaglandins and the regulation of tumor growth. (2002) (81)
An engineered S1P chaperone attenuates hypertension and ischemic injury (2017) (81)
Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. (2014) (81)
Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. (2017) (81)
Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. (1991) (80)
The mouse gene for the inducible G-protein-coupled receptor edg-1. (1997) (78)
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation (2007) (77)
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 (2015) (72)
Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning* (2012) (71)
Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-&ggr; Ligand Therapy (2002) (70)
C16:0-ceramide signals insulin resistance. (2014) (70)
Antagonistic Function of the RNA-binding Protein HuR and miR-200b in Post-transcriptional Regulation of Vascular Endothelial Growth Factor-A Expression and Angiogenesis* (2012) (70)
Lysophospholipid receptors in vertebrate development, physiology, and pathology Published, JLR Papers in Press, December 8, 2008. (2009) (70)
S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. (2017) (70)
Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells (2003) (70)
EP2 and EP4 Receptors Regulate Aromatase Expression in Human Adipocytes and Breast Cancer Cells (2008) (69)
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. (2004) (68)
Structure of the human cyclooxygenase-2 gene (2005) (68)
Induction of Antiproliferative Connective Tissue Growth Factor Expression in Wilms' Tumor Cells by Sphingosine-1-Phosphate Receptor 2 (2008) (66)
Bioactive lysolipids in cancer and angiogenesis. (2019) (66)
S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. (2009) (63)
Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. (2001) (60)
Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line (2000) (60)
Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells* (2008) (59)
The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. (2014) (58)
Sphingosine‐1‐Phosphate Signaling via the EDG‐1 Family of G‐Protein‐Coupled Receptors (2000) (58)
Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury (2018) (57)
Gene regulation by RNA binding proteins and microRNAs in angiogenesis. (2011) (56)
Sphingosine-1-phosphate signaling in endothelial activation. (2003) (55)
Sphingosine kinases are not required for inflammatory responses in macrophages. (2016) (55)
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. (2016) (54)
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis (2014) (54)
ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. (2014) (53)
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. (2005) (52)
Role of prostaglandin E 2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression (2004) (51)
CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration (2019) (51)
Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. (2001) (51)
Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells (2006) (50)
Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy (2020) (49)
S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity (2013) (48)
Isolation of the cDNA for human prostaglandin H synthase. (1986) (48)
HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. (2016) (47)
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. (2014) (47)
Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes (2019) (44)
Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. (2020) (42)
Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival (2017) (40)
Sphingosine Interaction with Acidic Leucine-rich Nuclear Phosphoprotein-32A (ANP32A) Regulates PP2A Activity and Cyclooxygenase (COX)-2 Expression in Human Endothelial Cells* (2010) (39)
Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. (2005) (38)
Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis (2014) (37)
Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript. (1996) (37)
Platelet‐derived growth factor (PDGF)‐induced chemotaxis does not require the G protein‐coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells (2003) (37)
Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model (2014) (36)
Cyclo-oxygenase-2 in vascular smooth muscle. (1999) (36)
SnapShot: Bioactive Lysophospholipids (2012) (36)
Genomic insights into mediator lipidomics. (2005) (35)
Isolation of immediate-early differentiation mRNAs by enzymatic amplification of subtracted cDNA from human endothelial cells. (1990) (34)
Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. (2004) (33)
PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. (2009) (33)
Evaluation of strategies to improve village chicken production: controlled field trials to assess effects of Newcastle disease vaccination and altered chick rearing in Myanmar [corrected]. (2009) (33)
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. (2009) (32)
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. (2019) (32)
FTY720 inhibits tumor growth and enhances the tumor‐suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway (2013) (31)
Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. (2020) (31)
Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. (2012) (30)
Role of Sphingosine 1-Phosphate in the Pathogenesis of Sjögren’s Syndrome1 (2008) (30)
S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling (2020) (30)
Bioluminescence imaging of G protein-coupled receptor activation in living mice (2017) (30)
Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions[S] (2014) (29)
Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. (1999) (29)
Mortality rates adjusted for unobserved deaths and associations with Newcastle disease virus serology among unvaccinated village chickens in Myanmar. (2008) (29)
S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. (2009) (29)
Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. (2014) (28)
COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. (2005) (28)
Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types (1991) (27)
Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. (2004) (27)
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. (2013) (26)
Husbandry and trade of indigenous chickens in Myanmar—Results of a participatory rural appraisal in the Yangon and the Mandalay divisions (2006) (24)
Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. (1995) (24)
Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice[S] (2019) (23)
Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases. (1990) (23)
Differential recovery of prostacyclin synthesis in cultured vascular endothelial vs. smooth muscle cells after inactivation of cyclooxygenase with aspirin. (1989) (23)
Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma (2015) (22)
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta (2019) (21)
S1P and the birth of platelets (2012) (21)
Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. (2014) (20)
Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction (2018) (20)
Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages* (2013) (20)
Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production (2019) (19)
Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. (2020) (19)
Sphingolipid Modulation of Angiogenic Factor Expression in Neuroblastoma (2011) (18)
Dietary Factors and Immunological Consequences (2005) (17)
Lysophospholipid Mediators in Health and Disease. (2021) (17)
Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. (2019) (15)
Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases (2022) (14)
Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S] (2017) (14)
Detection of cyclooxygenase-1 and -2 proteins and mRNA in gastric ulcer (1994) (14)
Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. (2000) (13)
Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis (2015) (13)
Fine-tuning S1P therapeutics. (2012) (13)
Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. (2014) (13)
Post‐transcriptional regulation of Nrf2‐mRNA by the mRNA‐binding proteins HuR and AUF1 (2019) (12)
Economic analysis of interventions to improve village chicken production in Myanmar. (2013) (11)
Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. (2006) (11)
The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (11)
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate (2021) (11)
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function (2021) (10)
Quality Versus Quantity: Making HDL Great Again. (2017) (10)
Regulation of a Vascular Plexus by gata4 Is Mediated in Zebrafish through the Chemokine sdf1a (2012) (10)
Lysolipids in Vascular Development, Biology, and Disease. (2020) (9)
Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells. (2019) (8)
The immediate‐early gene product MAD‐3/EDG‐3/IκBα is an endogenous modulator of fibroblast growth factor‐1 (FGF‐1) dependent human endothelial cell growth (1997) (7)
Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-Induced Pulmonary Fibrosis. (2021) (7)
The immediate-early gene product MAD-3/EDG-3/IkappaB alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth. (1997) (6)
Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. (2012) (6)
IoT-Based SCADA System Design and Generation Forecasting for Hydropower Station (2021) (6)
Recovery of prostacyclin synthesis in human vascular endothelial cells following intermittent or continuous exposure to indomethacin. (1985) (5)
Mapping Pathways Downstream of S1P1 by Differential Chemical Perturbation and Proteomics (2007) (5)
Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 (2017) (4)
Inhibition of Helper T Cell Responses Mediates g Immunoregulation: PPAR and g The Nuclear Receptor PPAR (2000) (4)
Village chicken production in Myanmar - characteristics, constraints and methods for improving the health and production of village chickens (2005) (4)
Switching Intracellular Signaling Pathways to Study Sphingosine 1‐Phosphate Receptors (2000) (4)
Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. (2020) (3)
Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 (2003) (3)
Inhibition of gene expression in vivo using multiplex siRNA. (2005) (3)
Early Response Genes in Endothelial Cells (1994) (3)
Erratum: Sphingosine kinases are not required for inflammatory responses in macrophages (The Journal of Biological Chemistry 288 (2013) 2563-32573) (2016) (3)
Outcomes and lessons from a smallholder poultry health project in Myanmar (2007) (3)
Sphingosine 1‐Phosphate (S1P) Receptors (2013) (3)
Ramping up RANTES in the acute response to arterial injury. (2010) (3)
Role of epidermal growth factor in cyclooxygenase synthesis. (1985) (3)
Controlled trials to assess effects of Newcastle disease vaccination and management changes in village chickens in Myanmar (2006) (2)
Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. (2018) (2)
A dark side to omega-3 fatty acids. (2017) (2)
Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. (2020) (2)
The ABCs of Lipophile Transport (2009) (2)
The dawn of lipidomics. (2005) (2)
Erratum to “Evaluation of strategies to improve village chicken production: Controlled field trials to assess effects of Newcastle disease vaccination and altered chick rearing in Myanmar” [Prev. Vet. Med. 90 (2009) 17–30] (2010) (2)
Sphingosine kinases protect murine embryonic stem cells from sphingosine‐induced cell cycle arrest (2020) (2)
Expression of CyclooxygenÃ¤se-1 -2 in Human Colorectal Cancer1 (1995) (2)
Erratum: HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P to limit vascular inflammation (Science Signaling) (2015) (2)
A dark side to omega-3 fatty acids (2017) (2)
Role of the Early Response Gene Cyclooxygenase (Cox)-2 in Angiogenesis (1996) (1)
Plasma components to protect the endothelial barrier after shock: A role for sphingosine 1-phosphate (2021) (1)
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function (2022) (1)
Newcastle disease and major constraints to village chicken production in Myanmar (2004) (1)
2-induced breast cancer progression -dependent angiogenic switch in cyclooxygenase 2 From the Cover: Role of prostaglandin E (2006) (1)
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis (2022) (1)
Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. (2023) (1)
Regulation of Cyclooxygenase Gene Expression in Vascular Endothelial Cells (1991) (1)
Assessing incidence rates of mortality adjusted for unobserved deaths among free-ranging village chickens (2006) (1)
Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis (2019) (1)
Endothelial sphingosine 1-phosphate receptors promote vascular normalization to influence tumor growth and metastasis (2019) (1)
150 CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AND SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR 1 AND 2 LEVELS ARE ALTERED IN WILM'S TUMOR (2012) (1)
First International Conference on Lysophospholipids and Related Bioactive Lipids in Biology and Disease Sponsored by the Federation of American Societies of Experimental Biology (2001) (1)
Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. (2009) (1)
Lysophospholipid (LPA) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
S 1 P and the birth of platelets (2012) (1)
Corrigendum to “Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells” [Prostag. Oth. Lipid. M. 76 (2005) 95–104] (2006) (1)
Regulation of Cyclooxygenase Synthesis in Vascular Smooth Muscle Cells by Epidermal Growth Factor (1985) (1)
Signal Transduction and Gene Regulation in the Endothelium. (2022) (1)
Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. (2018) (1)
Heterotypic inter-GPCR ß-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes (2018) (1)
294 Conditional Intestine-Specific HuR Deletion (HuR-IKO) Modulates Distinct Wnt-Dependent and Independent Pathways of Proliferation and Apoptosis With No Effect on Ileal ASBT Expression or Bile Acid Metabolism (2014) (0)
Antitumor activity of a novel S1P2 antagonist, AB1, in neuroblastoma (2015) (0)
Abstract 122: Ceramide Activation of Macrophage RhoA/Rho Kinase/LIM Kinase Signaling Impairs Aggregated LDL Degradation and Foam Cell Formation (2015) (0)
The Effect of Sphingosine 1-Phosphate Receptor Antagonism on VEGF-Induced Retinal Vascular Permeability (2011) (0)
Support Myanmar’s embattled scientists and students (2021) (0)
Sphingosine 1‐phosphate signaling in vascular and immune systems (96.2) (2014) (0)
Abstract 067: Endothelial S1P/S1P1 Signaling is Critical Regulator of Blood Flow and Pressure (2015) (0)
Corrigendum to "Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells" [Biochim Biophys Acta Gen Subj. volume 1863 (6) (2019) 1079-1087]. (2022) (0)
A festschrift for J. Martyn Bailey, a biochemist extraordinaire. (2007) (0)
Cells Plugging Vascular Leak by Sphingosine Kinase From Bone Marrow Progenitor (2011) (0)
Lymphatic endothelial S 1 P promotes naïve T cell mitochondrial function and survival (2017) (0)
EDG-1, an Endothelial-Derived G Protein-Coupled Receptor for Bioactive Lipids, Regulates Morphogenetic Differentiation (1999) (0)
55 NOVEL ANALOGS OF FTY720 PROMOTE PULMONARY VASCULAR BARRIER FUNCTION. (2006) (0)
Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy (2022) (0)
ConnecticutHealthCenter,Farmington,Connecticut06030,theDepartmentofMedicine,DivisionofCardiology,andDepartmentof PharmacologyandCancerBiology,DukeUniversityMedicalCenter,Durham,NorthCarolina27710,andthe**GreenebaumCancerCenter, DepartmentofBiochemistryandMolecularBiology,UniversityofMarylandSchoolof (2008) (0)
Bioluminescence imaging of G protein-coupled receptor activation in living mice (2017) (0)
Endothelial Transporter Spinster 2 (SPNS2) and Apolipoprotein M (ApoM) Regulation of Vascular Tone and Hypertension via Sphingosine‐1‐phosphate (S1P) (2021) (0)
Receptor-null Mice 2 S1P Deafness and Stria Vascularis Defects in Mechanisms of Signal Transduction: (2014) (0)
Sphingolipid chaperone proteins modulate signal transduction and pathophysiology (2017) (0)
S 1 P as a Bioactive Lipid Mediator in the Cardiovascular System (2004) (0)
The role of sphingosine-1-phosphate receptor-1 in antigen-specific CD8 T cell migration (173.14) (2012) (0)
Recovery of prostacyclin synthesis in vascular smooth muscle cells following self-inactivation and requirement for growth factors (1986) (0)
Macrophage catabolism of aggregated lipoproteins using a novel extracellular compartment regulates lipid accumulation during atherosclerosis (2017) (0)
Sphingosine‐1‐phosphate and S1P Receptors in Angiogenesis (2006) (0)
Author response: The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (0)
98: Down-regulation of sphingosine 1-phosphate receptor-1 in intestinal tumorigenesis (2006) (0)
Author response: The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (0)
Endothelial Biomedicine: Sphingolipids and the Endothelium (2007) (0)
Signal transduction in tumor angiogenesis (2015) (0)
Signal transduction and developmental expression of edg-1, an inducible g-protein coupled receptor (1996) (0)
Foxo Function in the Metabolic Syndrome (2014) (0)
A window into endothelial injury mechanisms revealed by S1PR1 GPCR reporter mice (2018) (0)
Pathogenesis of Sjögren's Syndrome Role of Sphingosine 1-Phosphate in the (2008) (0)
TARGETING SPHINGOSINE-1-PHOSPHATE RECEPTORS AS ANTI-TUMOR AND ANTI-ANGIOGENIC THERAPY IN RENAL CELL CARCINOMA (2008) (0)
Structure of apolioprotein M in complex with Sphingosine 1-Phosphate (2011) (0)
Science Signaling Podcast: 11 August 2015 (2015) (0)
776 Cyclooxygenase and non-small cell lung cancer (1997) (0)
Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis (2022) (0)
TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates (2019) (0)
1206 Sphingosine 1-phosphate (S1P) regulation of vascular and immune systems: Mechanisms and therapeutic approaches (2022) (0)
Decision letter: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis (2019) (0)
Molecular Characterisation of Field Isolates of Newcastle Disease Virus in Myanmar (2008) (0)
Sphingosine 1-phosphate in coagulation and inflammation (2011) (0)
Tu1732 Conditional Intestinal-Epithelial Specific HuR Deletion Modifies Murine Intestinal Tumorigenesis (2013) (0)
230 Conditional Intestine-Specific HuR Deletion (HuR-Iko) Modifies Epithelial Growth, Response to Injury and Tumorigenesis (2013) (0)
Sphingosine 1-Phosphate Receptor Modulation as a Therapeutic Target in Retinal Angiogenesis (2011) (0)
Abstract 649: Endothelial-derived Sphingolipids Preserve Systemic Vascular Function And Blood Pressure (2014) (0)
127 POSTER Down-regulation of Sphingosine 1-Phosphate Receptor-1 in intestinal tumorigenesis (2006) (0)
837 INDUCTION OF MONOCYTE CHEMOATTRACTANT PROTEIN 1 BY SPHINGOSINE-1-PHOSPHATE IN NEUROBLASTOMA (2012) (0)
Microsoft Word-macrophageSphkKOfinalRev2.docx (2013) (0)
Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation (2022) (0)
receptor 2 signaling induces COX-2 expression in Wilms tumor (2014) (0)
RED CELLS , IRON , AND ERYTHROPOIESIS Elavl 1 a regulates zebra fi sh erythropoiesis via posttranscriptional control of gata 1 (2014) (0)
Regulation of Expression and the Functional Role of Cyclooxygenase-2 (1996) (0)
Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. (2022) (0)
EDG-1 family of sphingosine-1-phosphate (SPP) receptors (1999) (0)
MicroRNA 33A controls SREBP-2 and LXR dependent regulation of the LDL receptor pathway (2022) (0)
Application of the RNA Interference (RNAi) Technology to Angiogenesis Research (2004) (0)
Limitations and Opportunities for Village chicken Production in Myanmar (2008) (0)
Advances in Brief Cytoplasmic HuR Expression Correlates with Poor Outcome and with Cyclooxygenase 2 Expression in Serous Ovarian Carcinoma (2003) (0)

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