Timothy Hla
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Vascular Biology researcher
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Timothy Hla's Degrees
- PhD Biochemistry University of California, San Francisco
- Doctorate Medicine Harvard University
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(Suggest an Edit or Addition)Timothy Hla's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004) (1612)
- Human cyclooxygenase-2 cDNA. (1992) (1449)
- Expression of cyclooxygenase-1 and -2 in human colorectal cancer. (1995) (1220)
- Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. (2000) (1180)
- Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (1998) (1014)
- Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate (1999) (996)
- Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice* (2001) (846)
- Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. (1994) (684)
- Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis (1995) (573)
- Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. (1989) (571)
- Lysophospholipids--Receptor Revelations (2001) (535)
- Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M (2011) (515)
- Regulation of PTEN by Rho small GTPases (2005) (496)
- Structure of the human cyclo-oxygenase-2 gene. (1994) (496)
- The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses1 (2000) (495)
- Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival (1998) (487)
- Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. (1994) (483)
- International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature (2002) (482)
- Structural and functional characteristics of S1P receptors (2004) (481)
- An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. (1990) (476)
- FTY720: Sphingosine 1‐Phosphate Receptor‐1 in the Control of Lymphocyte Egress and Endothelial Barrier Function (2004) (462)
- Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. (1990) (461)
- Endothelial Cell Apoptosis Induced by the Peroxisome Proliferator-activated Receptor (PPAR) Ligand 15-Deoxy-Δ12,14-prostaglandin J2 * (1999) (461)
- Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate (2008) (457)
- Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. (1994) (429)
- Physiological and pathological actions of sphingosine 1-phosphate. (2004) (407)
- Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. (2015) (398)
- Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor* (2007) (390)
- Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability* (2003) (384)
- Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. (2004) (376)
- An update on the biology of sphingosine 1-phosphate receptors (2014) (375)
- 15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats (2000) (372)
- Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland (2011) (368)
- Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins* (1999) (356)
- In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. (1992) (353)
- Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. (1990) (349)
- Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. (2002) (336)
- Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8* (2000) (332)
- Expression of cyclooxygenase‐2 in prostate carcinoma (2000) (330)
- Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. (2000) (323)
- International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature (2010) (319)
- Induction of Vascular Permeability by the Sphingosine-1-Phosphate Receptor–2 (S1P2R) and its Downstream Effectors ROCK and PTEN (2007) (306)
- Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (2001) (305)
- Extracellular Export of Sphingosine Kinase-1 Enzyme (2002) (286)
- Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins* (2001) (284)
- Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. (2006) (284)
- Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells* (2001) (279)
- Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. (1997) (270)
- Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. (2004) (265)
- Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. (2012) (264)
- Signaling and biological actions of sphingosine 1-phosphate. (2003) (263)
- Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5* (1999) (262)
- Point-Counterpoint of Sphingosine 1-Phosphate Metabolism (2004) (255)
- HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation (2015) (247)
- Sphingosine 1-phosphate: Lipid signaling in pathology and therapy (2019) (244)
- S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. (2005) (239)
- Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation (2006) (236)
- Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. (2007) (234)
- Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. (1996) (231)
- Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. (2004) (226)
- Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. (2006) (219)
- Cyclooxygenase-1 and -2 isoenzymes. (1999) (216)
- Sphingosine 1-phosphate signalling (2014) (214)
- Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis (2015) (214)
- Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. (2005) (211)
- Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice* (2007) (201)
- Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. (2011) (196)
- Prostaglandins & other lipid mediators: a new phase, a new team. (2004) (193)
- Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. (1999) (189)
- HDL-bound sphingosine 1-phosphate restrains lymphopoiesis and neuroinflammation (2015) (184)
- Cyclooxygenase Gene Expression in Inflammation and Angiogenesis a (1993) (180)
- The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. (2005) (180)
- Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesis (2003) (180)
- Sphingolipid signaling in metabolic disorders. (2012) (179)
- The vascular S1P gradient-cellular sources and biological significance. (2008) (178)
- The RNA-binding Protein HuR Regulates the Expression of Cyclooxygenase-2* (2003) (175)
- Dual Roles of Tight Junction-associated Protein, Zonula Occludens-1, in Sphingosine 1-Phosphate-mediated Endothelial Chemotaxis and Barrier Integrity* (2006) (174)
- Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration (2001) (173)
- Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? (1999) (171)
- PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. (2005) (170)
- Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. (2009) (169)
- Sphingosine 1-phosphate receptors. (2001) (168)
- The Inducible G Protein-coupled Receptor edg-1 Signals via the G/Mitogen-activated Protein Kinase Pathway (*) (1996) (168)
- TWEAK Is an Endothelial Cell Growth and Chemotactic Factor That Also Potentiates FGF-2 and VEGF-A Mitogenic Activity (2003) (162)
- Sphingosine 1-phosphate in coagulation and inflammation (2011) (158)
- HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. (2005) (158)
- Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics (2010) (156)
- Sphingosine 1-phosphate (S1P) (2011) (152)
- Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. (2014) (149)
- Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. (2006) (145)
- Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis (2011) (144)
- Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. (2003) (142)
- Defective sphingosine-1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation (2013) (142)
- Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1 (2017) (141)
- 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. (2000) (135)
- Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. (2011) (134)
- Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation (2009) (126)
- Sphingosine 1-phosphate and inflammation. (2019) (124)
- Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 Expression* (2003) (124)
- Sphingosine‐1‐phosphate receptor 1 signalling in T cells: trafficking and beyond (2014) (123)
- Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist* (1998) (121)
- Overexpression of Cyclooxygenase-2 Induces Cell Cycle Arrest (1999) (120)
- Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs. (1998) (115)
- The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. (2005) (114)
- S1P control of endothelial integrity. (2014) (113)
- Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression* (1997) (108)
- Constitutive expression of the S1P1 receptor in adult tissues. (2004) (106)
- A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). (2007) (105)
- HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. (2006) (103)
- Regulation of vascular physiology and pathology by the S1P2 receptor subtype. (2008) (102)
- Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. (2001) (99)
- Sphingosine 1-phosphate (2012) (95)
- Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells (2017) (95)
- Impaired endothelial barrier function in apolipoprotein M‐deficient mice is dependent on sphingosine‐1‐phosphate receptor 1 (2016) (91)
- Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor. (1985) (90)
- Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure (2015) (89)
- Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. (2008) (88)
- Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. (1993) (87)
- Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. (2001) (86)
- Serum Withdrawal-induced Post-transcriptional Stabilization of Cyclooxygenase-2 mRNA in MDA-MB-231 Mammary Carcinoma Cells Requires the Activity of the p38 Stress-activated Protein Kinase* (2000) (86)
- Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical Perturbation and Proteomics* (2007) (85)
- Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice (2006) (85)
- Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. (1991) (84)
- Dissociation of basal turnover and cytokine-induced transcript stabilization of the human cyclooxygenase-2 mRNA by mutagenesis of the 3'-untranslated region. (1998) (82)
- Prostaglandins and the regulation of tumor growth. (2002) (81)
- An engineered S1P chaperone attenuates hypertension and ischemic injury (2017) (81)
- Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. (2014) (81)
- Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. (2017) (81)
- Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. (1991) (80)
- The mouse gene for the inducible G-protein-coupled receptor edg-1. (1997) (78)
- COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation (2007) (77)
- TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 (2015) (72)
- Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning* (2012) (71)
- Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-&ggr; Ligand Therapy (2002) (70)
- C16:0-ceramide signals insulin resistance. (2014) (70)
- Antagonistic Function of the RNA-binding Protein HuR and miR-200b in Post-transcriptional Regulation of Vascular Endothelial Growth Factor-A Expression and Angiogenesis* (2012) (70)
- Lysophospholipid receptors in vertebrate development, physiology, and pathology Published, JLR Papers in Press, December 8, 2008. (2009) (70)
- S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. (2017) (70)
- Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells (2003) (70)
- EP2 and EP4 Receptors Regulate Aromatase Expression in Human Adipocytes and Breast Cancer Cells (2008) (69)
- Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. (2004) (68)
- Structure of the human cyclooxygenase-2 gene (2005) (68)
- Induction of Antiproliferative Connective Tissue Growth Factor Expression in Wilms' Tumor Cells by Sphingosine-1-Phosphate Receptor 2 (2008) (66)
- Bioactive lysolipids in cancer and angiogenesis. (2019) (66)
- S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. (2009) (63)
- Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. (2001) (60)
- Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line (2000) (60)
- Up-regulating Sphingosine 1-Phosphate Receptor-2 Signaling Impairs Chemotactic, Wound-healing, and Morphogenetic Responses in Senescent Endothelial Cells* (2008) (59)
- The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. (2014) (58)
- Sphingosine‐1‐Phosphate Signaling via the EDG‐1 Family of G‐Protein‐Coupled Receptors (2000) (58)
- Sphingosine 1‐Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex–Induced Vascular Injury (2018) (57)
- Gene regulation by RNA binding proteins and microRNAs in angiogenesis. (2011) (56)
- Sphingosine-1-phosphate signaling in endothelial activation. (2003) (55)
- Sphingosine kinases are not required for inflammatory responses in macrophages. (2016) (55)
- Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. (2016) (54)
- ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis (2014) (54)
- ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. (2014) (53)
- Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. (2005) (52)
- Role of prostaglandin E 2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression (2004) (51)
- CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration (2019) (51)
- Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. (2001) (51)
- Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells (2006) (50)
- Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy (2020) (49)
- S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity (2013) (48)
- Isolation of the cDNA for human prostaglandin H synthase. (1986) (48)
- HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. (2016) (47)
- Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. (2014) (47)
- Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes (2019) (44)
- Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. (2020) (42)
- Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival (2017) (40)
- Sphingosine Interaction with Acidic Leucine-rich Nuclear Phosphoprotein-32A (ANP32A) Regulates PP2A Activity and Cyclooxygenase (COX)-2 Expression in Human Endothelial Cells* (2010) (39)
- Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. (2005) (38)
- Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis (2014) (37)
- Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript. (1996) (37)
- Platelet‐derived growth factor (PDGF)‐induced chemotaxis does not require the G protein‐coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells (2003) (37)
- Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model (2014) (36)
- Cyclo-oxygenase-2 in vascular smooth muscle. (1999) (36)
- SnapShot: Bioactive Lysophospholipids (2012) (36)
- Genomic insights into mediator lipidomics. (2005) (35)
- Isolation of immediate-early differentiation mRNAs by enzymatic amplification of subtracted cDNA from human endothelial cells. (1990) (34)
- Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. (2004) (33)
- PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. (2009) (33)
- Evaluation of strategies to improve village chicken production: controlled field trials to assess effects of Newcastle disease vaccination and altered chick rearing in Myanmar [corrected]. (2009) (33)
- Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. (2009) (32)
- TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. (2019) (32)
- FTY720 inhibits tumor growth and enhances the tumor‐suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway (2013) (31)
- Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. (2020) (31)
- Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. (2012) (30)
- Role of Sphingosine 1-Phosphate in the Pathogenesis of Sjögren’s Syndrome1 (2008) (30)
- S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling (2020) (30)
- Bioluminescence imaging of G protein-coupled receptor activation in living mice (2017) (30)
- Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions[S] (2014) (29)
- Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. (1999) (29)
- Mortality rates adjusted for unobserved deaths and associations with Newcastle disease virus serology among unvaccinated village chickens in Myanmar. (2008) (29)
- S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. (2009) (29)
- Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. (2014) (28)
- COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. (2005) (28)
- Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types (1991) (27)
- Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. (2004) (27)
- Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. (2013) (26)
- Husbandry and trade of indigenous chickens in Myanmar—Results of a participatory rural appraisal in the Yangon and the Mandalay divisions (2006) (24)
- Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. (1995) (24)
- Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice[S] (2019) (23)
- Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases. (1990) (23)
- Differential recovery of prostacyclin synthesis in cultured vascular endothelial vs. smooth muscle cells after inactivation of cyclooxygenase with aspirin. (1989) (23)
- Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma (2015) (22)
- Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta (2019) (21)
- S1P and the birth of platelets (2012) (21)
- Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. (2014) (20)
- Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction (2018) (20)
- Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages* (2013) (20)
- Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production (2019) (19)
- Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. (2020) (19)
- Sphingolipid Modulation of Angiogenic Factor Expression in Neuroblastoma (2011) (18)
- Dietary Factors and Immunological Consequences (2005) (17)
- Lysophospholipid Mediators in Health and Disease. (2021) (17)
- Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. (2019) (15)
- Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases (2022) (14)
- Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S] (2017) (14)
- Detection of cyclooxygenase-1 and -2 proteins and mRNA in gastric ulcer (1994) (14)
- Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. (2000) (13)
- Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis (2015) (13)
- Fine-tuning S1P therapeutics. (2012) (13)
- Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. (2014) (13)
- Post‐transcriptional regulation of Nrf2‐mRNA by the mRNA‐binding proteins HuR and AUF1 (2019) (12)
- Economic analysis of interventions to improve village chicken production in Myanmar. (2013) (11)
- Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. (2006) (11)
- The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (11)
- Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate (2021) (11)
- CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function (2021) (10)
- Quality Versus Quantity: Making HDL Great Again. (2017) (10)
- Regulation of a Vascular Plexus by gata4 Is Mediated in Zebrafish through the Chemokine sdf1a (2012) (10)
- Lysolipids in Vascular Development, Biology, and Disease. (2020) (9)
- Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells. (2019) (8)
- The immediate‐early gene product MAD‐3/EDG‐3/IκBα is an endogenous modulator of fibroblast growth factor‐1 (FGF‐1) dependent human endothelial cell growth (1997) (7)
- Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-Induced Pulmonary Fibrosis. (2021) (7)
- The immediate-early gene product MAD-3/EDG-3/IkappaB alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth. (1997) (6)
- Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. (2012) (6)
- IoT-Based SCADA System Design and Generation Forecasting for Hydropower Station (2021) (6)
- Recovery of prostacyclin synthesis in human vascular endothelial cells following intermittent or continuous exposure to indomethacin. (1985) (5)
- Mapping Pathways Downstream of S1P1 by Differential Chemical Perturbation and Proteomics (2007) (5)
- Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 (2017) (4)
- Inhibition of Helper T Cell Responses Mediates g Immunoregulation: PPAR and g The Nuclear Receptor PPAR (2000) (4)
- Village chicken production in Myanmar - characteristics, constraints and methods for improving the health and production of village chickens (2005) (4)
- Switching Intracellular Signaling Pathways to Study Sphingosine 1‐Phosphate Receptors (2000) (4)
- Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. (2020) (3)
- Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 (2003) (3)
- Inhibition of gene expression in vivo using multiplex siRNA. (2005) (3)
- Early Response Genes in Endothelial Cells (1994) (3)
- Erratum: Sphingosine kinases are not required for inflammatory responses in macrophages (The Journal of Biological Chemistry 288 (2013) 2563-32573) (2016) (3)
- Outcomes and lessons from a smallholder poultry health project in Myanmar (2007) (3)
- Sphingosine 1‐Phosphate (S1P) Receptors (2013) (3)
- Ramping up RANTES in the acute response to arterial injury. (2010) (3)
- Role of epidermal growth factor in cyclooxygenase synthesis. (1985) (3)
- Controlled trials to assess effects of Newcastle disease vaccination and management changes in village chickens in Myanmar (2006) (2)
- Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. (2018) (2)
- A dark side to omega-3 fatty acids. (2017) (2)
- Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. (2020) (2)
- The ABCs of Lipophile Transport (2009) (2)
- The dawn of lipidomics. (2005) (2)
- Erratum to “Evaluation of strategies to improve village chicken production: Controlled field trials to assess effects of Newcastle disease vaccination and altered chick rearing in Myanmar” [Prev. Vet. Med. 90 (2009) 17–30] (2010) (2)
- Sphingosine kinases protect murine embryonic stem cells from sphingosine‐induced cell cycle arrest (2020) (2)
- Expression of Cyclooxygenäse-1 -2 in Human Colorectal Cancer1 (1995) (2)
- Erratum: HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P to limit vascular inflammation (Science Signaling) (2015) (2)
- A dark side to omega-3 fatty acids (2017) (2)
- Role of the Early Response Gene Cyclooxygenase (Cox)-2 in Angiogenesis (1996) (1)
- Plasma components to protect the endothelial barrier after shock: A role for sphingosine 1-phosphate (2021) (1)
- DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function (2022) (1)
- Newcastle disease and major constraints to village chicken production in Myanmar (2004) (1)
- 2-induced breast cancer progression -dependent angiogenic switch in cyclooxygenase 2 From the Cover: Role of prostaglandin E (2006) (1)
- Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis (2022) (1)
- Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. (2023) (1)
- Regulation of Cyclooxygenase Gene Expression in Vascular Endothelial Cells (1991) (1)
- Assessing incidence rates of mortality adjusted for unobserved deaths among free-ranging village chickens (2006) (1)
- Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis (2019) (1)
- Endothelial sphingosine 1-phosphate receptors promote vascular normalization to influence tumor growth and metastasis (2019) (1)
- 150 CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AND SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR 1 AND 2 LEVELS ARE ALTERED IN WILM'S TUMOR (2012) (1)
- First International Conference on Lysophospholipids and Related Bioactive Lipids in Biology and Disease Sponsored by the Federation of American Societies of Experimental Biology (2001) (1)
- Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. (2009) (1)
- Lysophospholipid (LPA) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
- S 1 P and the birth of platelets (2012) (1)
- Corrigendum to “Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells” [Prostag. Oth. Lipid. M. 76 (2005) 95–104] (2006) (1)
- Regulation of Cyclooxygenase Synthesis in Vascular Smooth Muscle Cells by Epidermal Growth Factor (1985) (1)
- Signal Transduction and Gene Regulation in the Endothelium. (2022) (1)
- Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. (2018) (1)
- Heterotypic inter-GPCR ß-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes (2018) (1)
- 294 Conditional Intestine-Specific HuR Deletion (HuR-IKO) Modulates Distinct Wnt-Dependent and Independent Pathways of Proliferation and Apoptosis With No Effect on Ileal ASBT Expression or Bile Acid Metabolism (2014) (0)
- Antitumor activity of a novel S1P2 antagonist, AB1, in neuroblastoma (2015) (0)
- Abstract 122: Ceramide Activation of Macrophage RhoA/Rho Kinase/LIM Kinase Signaling Impairs Aggregated LDL Degradation and Foam Cell Formation (2015) (0)
- The Effect of Sphingosine 1-Phosphate Receptor Antagonism on VEGF-Induced Retinal Vascular Permeability (2011) (0)
- Support Myanmar’s embattled scientists and students (2021) (0)
- Sphingosine 1‐phosphate signaling in vascular and immune systems (96.2) (2014) (0)
- Abstract 067: Endothelial S1P/S1P1 Signaling is Critical Regulator of Blood Flow and Pressure (2015) (0)
- Corrigendum to "Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells" [Biochim Biophys Acta Gen Subj. volume 1863 (6) (2019) 1079-1087]. (2022) (0)
- A festschrift for J. Martyn Bailey, a biochemist extraordinaire. (2007) (0)
- Cells Plugging Vascular Leak by Sphingosine Kinase From Bone Marrow Progenitor (2011) (0)
- Lymphatic endothelial S 1 P promotes naïve T cell mitochondrial function and survival (2017) (0)
- EDG-1, an Endothelial-Derived G Protein-Coupled Receptor for Bioactive Lipids, Regulates Morphogenetic Differentiation (1999) (0)
- 55 NOVEL ANALOGS OF FTY720 PROMOTE PULMONARY VASCULAR BARRIER FUNCTION. (2006) (0)
- Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy (2022) (0)
- ConnecticutHealthCenter,Farmington,Connecticut06030,theDepartmentofMedicine,DivisionofCardiology,andDepartmentof PharmacologyandCancerBiology,DukeUniversityMedicalCenter,Durham,NorthCarolina27710,andthe**GreenebaumCancerCenter, DepartmentofBiochemistryandMolecularBiology,UniversityofMarylandSchoolof (2008) (0)
- Bioluminescence imaging of G protein-coupled receptor activation in living mice (2017) (0)
- Endothelial Transporter Spinster 2 (SPNS2) and Apolipoprotein M (ApoM) Regulation of Vascular Tone and Hypertension via Sphingosine‐1‐phosphate (S1P) (2021) (0)
- Receptor-null Mice 2 S1P Deafness and Stria Vascularis Defects in Mechanisms of Signal Transduction: (2014) (0)
- Sphingolipid chaperone proteins modulate signal transduction and pathophysiology (2017) (0)
- S 1 P as a Bioactive Lipid Mediator in the Cardiovascular System (2004) (0)
- The role of sphingosine-1-phosphate receptor-1 in antigen-specific CD8 T cell migration (173.14) (2012) (0)
- Recovery of prostacyclin synthesis in vascular smooth muscle cells following self-inactivation and requirement for growth factors (1986) (0)
- Macrophage catabolism of aggregated lipoproteins using a novel extracellular compartment regulates lipid accumulation during atherosclerosis (2017) (0)
- Sphingosine‐1‐phosphate and S1P Receptors in Angiogenesis (2006) (0)
- Author response: The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (0)
- 98: Down-regulation of sphingosine 1-phosphate receptor-1 in intestinal tumorigenesis (2006) (0)
- Author response: The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis (2017) (0)
- Endothelial Biomedicine: Sphingolipids and the Endothelium (2007) (0)
- Signal transduction in tumor angiogenesis (2015) (0)
- Signal transduction and developmental expression of edg-1, an inducible g-protein coupled receptor (1996) (0)
- Foxo Function in the Metabolic Syndrome (2014) (0)
- A window into endothelial injury mechanisms revealed by S1PR1 GPCR reporter mice (2018) (0)
- Pathogenesis of Sjögren's Syndrome Role of Sphingosine 1-Phosphate in the (2008) (0)
- TARGETING SPHINGOSINE-1-PHOSPHATE RECEPTORS AS ANTI-TUMOR AND ANTI-ANGIOGENIC THERAPY IN RENAL CELL CARCINOMA (2008) (0)
- Structure of apolioprotein M in complex with Sphingosine 1-Phosphate (2011) (0)
- Science Signaling Podcast: 11 August 2015 (2015) (0)
- 776 Cyclooxygenase and non-small cell lung cancer (1997) (0)
- Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis (2022) (0)
- TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates (2019) (0)
- 1206 Sphingosine 1-phosphate (S1P) regulation of vascular and immune systems: Mechanisms and therapeutic approaches (2022) (0)
- Decision letter: Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis (2019) (0)
- Molecular Characterisation of Field Isolates of Newcastle Disease Virus in Myanmar (2008) (0)
- Sphingosine 1-phosphate in coagulation and inflammation (2011) (0)
- Tu1732 Conditional Intestinal-Epithelial Specific HuR Deletion Modifies Murine Intestinal Tumorigenesis (2013) (0)
- 230 Conditional Intestine-Specific HuR Deletion (HuR-Iko) Modifies Epithelial Growth, Response to Injury and Tumorigenesis (2013) (0)
- Sphingosine 1-Phosphate Receptor Modulation as a Therapeutic Target in Retinal Angiogenesis (2011) (0)
- Abstract 649: Endothelial-derived Sphingolipids Preserve Systemic Vascular Function And Blood Pressure (2014) (0)
- 127 POSTER Down-regulation of Sphingosine 1-Phosphate Receptor-1 in intestinal tumorigenesis (2006) (0)
- 837 INDUCTION OF MONOCYTE CHEMOATTRACTANT PROTEIN 1 BY SPHINGOSINE-1-PHOSPHATE IN NEUROBLASTOMA (2012) (0)
- Microsoft Word-macrophageSphkKOfinalRev2.docx (2013) (0)
- Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation (2022) (0)
- receptor 2 signaling induces COX-2 expression in Wilms tumor (2014) (0)
- RED CELLS , IRON , AND ERYTHROPOIESIS Elavl 1 a regulates zebra fi sh erythropoiesis via posttranscriptional control of gata 1 (2014) (0)
- Regulation of Expression and the Functional Role of Cyclooxygenase-2 (1996) (0)
- Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. (2022) (0)
- EDG-1 family of sphingosine-1-phosphate (SPP) receptors (1999) (0)
- MicroRNA 33A controls SREBP-2 and LXR dependent regulation of the LDL receptor pathway (2022) (0)
- Application of the RNA Interference (RNAi) Technology to Angiogenesis Research (2004) (0)
- Limitations and Opportunities for Village chicken Production in Myanmar (2008) (0)
- Advances in Brief Cytoplasmic HuR Expression Correlates with Poor Outcome and with Cyclooxygenase 2 Expression in Serous Ovarian Carcinoma (2003) (0)
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What Schools Are Affiliated With Timothy Hla?
Timothy Hla is affiliated with the following schools:
- George Washington University
- Weill Cornell Medicine
- University of California, San Diego
- Cornell University
- Chungbuk National University
- University of California, San Francisco
- Duke University
- Stanford University
- Georgetown University
- Johns Hopkins University
- Queen Mary University of London
- University of Connecticut
- Harvard University