Timothy J. Ley | Academic Influence

Timothy J. Ley's AcademicInfluence.com Rankings

Timothy J. Ley

Medical

#788

World Rank

#1036

Historical Rank

Hematology

#13

World Rank

#14

Historical Rank

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Medical

Timothy J. Ley's Degrees

Masters Medicine University of Chicago

Why Is Timothy J. Ley Influential?

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According to Wikipedia, Timothy J. Ley is an American hematologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the department of medicine, and is chief of the section of stem cell biology in the division of oncology at Washington University in St. Louis. He is a member of the Alvin J. Siteman Cancer Center.

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Timothy J. Ley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. (2013) (3821)
Mutational landscape and significance across 12 major cancer types (2013) (3589)
Recurring mutations found by sequencing an acute myeloid leukemia genome. (2009) (2200)
Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing (2011) (1935)
International network of cancer genome projects (2010) (1839)
Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018) (1646)
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia (2012) (1437)
The Origin and Evolution of Mutations in Acute Myeloid Leukemia (2012) (1420)
BreakDancer: An algorithm for high resolution mapping of genomic structural variation (2009) (1381)
DNA sequencing of a cytogenetically normal acute myeloid leukemia genome (2008) (1365)
Comprehensive Characterization of Cancer Driver Genes and Mutations (2018) (1360)
Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft (2010) (1171)
Age-related cancer mutations associated with clonal hematopoietic expansion (2014) (1053)
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. (2004) (1052)
Whole Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition (2012) (998)
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells (1994) (891)
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. (2007) (792)
DNMT3A mutations in acute myeloid leukemia. (2010) (782)
Clonal architecture of secondary acute myeloid leukemia. (2012) (747)
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis (1998) (701)
Lymphocyte-mediated cytotoxicity. (2003) (635)
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. (2016) (582)
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. (2004) (552)
SomaticSniper: identification of somatic point mutations in whole genome sequencing data (2012) (543)
RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES (2011) (530)
Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes (2011) (508)
Pathogenic Germline Variants in 10,389 Adult Cancers (2018) (501)
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. (1996) (499)
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. (2009) (482)
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. (1993) (479)
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients (2018) (471)
The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML (2014) (442)
How do cytotoxic lymphocytes kill their targets? (1998) (437)
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. (1982) (428)
Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. (2007) (424)
DGIdb - Mining the druggable genome (2013) (418)
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. (1999) (395)
SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution (2014) (381)
Long-range disruption of gene expression by a selectable marker cassette. (1996) (380)
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. (1997) (376)
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. (1995) (371)
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. (2014) (363)
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. (1995) (349)
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. (2014) (342)
The Pediatric Cancer Genome Project (2012) (311)
PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model (2002) (293)
Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. (2015) (285)
The physician-scientist career pipeline in 2005: build it, and they will come. (2005) (274)
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes (2013) (269)
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. (2011) (267)
Acquired copy number alterations in adult acute myeloid leukemia genomes (2009) (258)
Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide. (2001) (245)
Immune Escape of Relapsed AML Cells after Allogeneic Transplantation (2018) (235)
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. (1995) (230)
A High-Resolution Map of Segmental DNA Copy Number Variation in the Mouse Genome (2006) (229)
The Physician‐Scientist: Career Issues and Challenges at the Year 2000 (2000) (226)
Patterns and functional implications of rare germline variants across 12 cancer types (2015) (222)
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. (1997) (220)
DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. (2000) (217)
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. (2012) (215)
The Gender Gap in NIH Grant Applications (2008) (209)
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. (1992) (207)
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. (2002) (205)
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. (2008) (205)
Dipeptidyl Peptidase I Is Essential for Activation of Mast Cell Chymases, but Not Tryptases, in Mice* (2001) (203)
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. (2015) (197)
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. (2012) (195)
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context (2018) (188)
Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3 (1996) (186)
Granzyme A initiates an alternative pathway for granule-mediated apoptosis. (1999) (183)
Optimizing cancer genome sequencing and analysis. (2015) (179)
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. (2011) (169)
The orphan granzymes of humans and mice. (2003) (168)
YB-1 Is Important for Late-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence (2005) (165)
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia (1983) (158)
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression (2017) (155)
DNMT 3 A mutations in acute myeloid leukemia (2016) (151)
Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation* (1996) (150)
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. (2003) (144)
Papillon-Lefèvre Syndrome: Correlating the Molecular, Cellular, and Clinical Consequences of Cathepsin C/Dipeptidyl Peptidase I Deficiency in Humans1 (2004) (140)
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. (1996) (140)
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. (2009) (139)
Next-generation sequencing identifies the natural killer cell microRNA transcriptome. (2010) (139)
Neutrophil Elastase Cleaves PML-RARα and Is Important for the Development of Acute Promyelocytic Leukemia in Mice (2003) (136)
Genomic impact of transient low-dose decitabine treatment on primary AML cells. (2013) (135)
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential (2018) (135)
A proteomic approach for the discovery of protease substrates. (2004) (132)
Normal neutrophil function in cathepsin G-deficient mice. (1999) (132)
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production. (1986) (125)
Visualizing tumor evolution with the fishplot package for R (2016) (119)
Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. (2000) (119)
Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing (2014) (118)
A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia (1999) (117)
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK (2001) (117)
Advances in thalassemia research. (1984) (114)
Cell death induced by granzyme C. (2003) (111)
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing (2019) (111)
Inducible transcription of five globin genes in K562 human leukemia cells. (1983) (109)
Granzyme B and the Downstream Granzymes C and/or F Are Important for Cytotoxic Lymphocyte Functions1 (2005) (109)
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. (1990) (108)
Removing career obstacles for young physician-scientists -- loan-repayment programs. (2002) (106)
Genomic organization and chromosomal localization of the human cathepsin G gene. (1989) (106)
U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing (2014) (104)
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. (1993) (99)
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. (2009) (98)
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. (2008) (97)
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. (2011) (97)
RNA processing errors in patients with beta-thalassemia. (1982) (96)
An enhancer element lies 3′ to the human A gamma globin gene. (1987) (94)
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells (2015) (93)
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. (1983) (93)
Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. (2007) (92)
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML. (2016) (92)
Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (1989) (91)
Differences in human α-, β- and δ-globin gene expression in monkey kidney cells (1982) (91)
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha. (2005) (88)
Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. (2021) (86)
Developmental regulation of the human cathepsin G gene in myelomonocytic cells. (1990) (85)
fgr proto-oncogene mRNA induced in B lymphocytes by Epstein–Barr virus infection (1986) (81)
Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. (1999) (79)
Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy (2015) (78)
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. (1984) (77)
Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions during Murine Embryogenesis (2006) (76)
"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. (1983) (76)
Complete characterization of the microRNAome in a patient with acute myeloid leukemia. (2010) (75)
5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin. (1985) (75)
Granzyme B Plays a Critical Role in Cytotoxic Lymphocyte‐induced Apoptosis (1995) (73)
Clonal Architectures and Driver Mutations in Metastatic Melanomas (2014) (72)
Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. (2009) (71)
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes (2003) (70)
Latent herpesvirus infection arms NK cells. (2010) (70)
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. (2017) (69)
Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing (2015) (68)
A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. (1994) (68)
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells. (1990) (67)
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data (2012) (66)
Molecular Cloning, Chromosomal Localization, and Expression of Murine Dipeptidyl Peptidase I* (1997) (65)
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene (1989) (65)
A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus. (1990) (63)
Production of Fully Active Recombinant Murine Granzyme B in Yeast* (1998) (61)
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression (2020) (61)
Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice. (1994) (60)
Seed versus soil: the importance of the target cell for transgenic models of human leukemias. (1999) (60)
Mutation Clearance after Transplantation for Myelodysplastic Syndrome (2018) (57)
Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes* (1997) (56)
Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease (2006) (56)
The role of granzyme B cluster proteases in cell-mediated cytotoxicity. (1997) (56)
Structure and function of the murine β-globin locus control region 5′ HS-3 (1992) (52)
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. (1991) (52)
Functional properties of the beta-globin locus control region in K562 erythroleukemia cells. (1991) (52)
Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor α Activities in Early Myeloid Cells (2005) (51)
Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice. (1998) (51)
Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells. (1989) (49)
Transfusion haemosiderosis and chelation therapy. (1982) (48)
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. (1998) (47)
TP 53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes (2016) (47)
Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia (2012) (46)
Mouse models of acute promyelocytic leukemia (2001) (45)
Globin gene expression in erythroid human fetal liver cells. (1989) (45)
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation. (1992) (45)
The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. (1991) (45)
Pharmacological Manipulation of Fetal Hemoglobin Synthesis in Patients with Severe β‐Thalassemia (1985) (45)
Granzymes A and B are not expressed in human neutrophils. (2004) (44)
An Intramolecular Triplex in the Human γ-Globin 5′-Flanking Region Is Altered by Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin (*) (1995) (44)
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia (2002) (43)
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia. (2016) (42)
Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant. (2018) (42)
Commonly dysregulated genes in murine APL cells. (2007) (42)
Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region. (2000) (41)
Disseminated infection caused by Cunninghamella bertholletiae in a patient with beta-thalassemia. Case report and review of the literature. (2020) (40)
Spontaneous subarachnoid hemorrhage simulating acute transmural myocardial infarction. (1983) (39)
An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin. (1992) (39)
Co-evolution of tumor and immune cells during progression of multiple myeloma (2021) (38)
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. (2011) (38)
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. (1993) (38)
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. (1984) (37)
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro (2014) (37)
A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia. (1999) (36)
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma (2015) (35)
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. (2006) (35)
Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency (2004) (35)
wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data (2008) (33)
Differential Expression of Granzyme B and C in Murine Cytotoxic Lymphocytes1 (2009) (33)
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. (2010) (32)
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia. (2015) (32)
Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes. (1990) (32)
Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (2011) (31)
How do lymphocytes kill tumor cells? (1996) (31)
DNA methylation and globin gene expression in patients treated with 5-azacytidine. (1983) (31)
Expression Profiling of Murine Acute Promyelocytic Leukemia Cells Reveals Multiple Model-Dependent Progression Signatures (2004) (30)
Next-generation sequencing of cancer genomes: back to the future. (2009) (30)
Expression profiling of snoRNAs in normal hematopoiesis and AML. (2018) (29)
Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription. (1993) (27)
Mechanisms responsible for granzyme B-independent cytotoxicity. (1997) (27)
MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis. (2018) (27)
Notch Signaling in Acute Promyelocytic Leukemia (2013) (27)
Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia (2008) (27)
BreakTrans: uncovering the genomic architecture of gene fusions (2013) (26)
POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature (2010) (24)
The clonal evolution of metastatic colorectal cancer (2020) (24)
Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes. (1983) (23)
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. (2014) (23)
Bam-readcount - rapid generation of basepair-resolution sequence metrics (2021) (23)
Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe disease. (2020) (23)
Hop Cleavage and Function in Granzyme B-induced Apoptosis* (2006) (23)
Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells. (2003) (22)
Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription (1993) (21)
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes (1991) (21)
Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism (2019) (20)
Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing (2020) (19)
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy. (2017) (18)
1,25‐Dihydroxyvitamin D3 Induces Monocytic Differentiation of the PLB‐985 Leukemic Line and Promotes c‐fgr mRNA Expression (1991) (18)
Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: evidence for involvement of delayed transcriptional activation and enhanced mRNA stability. (1993) (17)
The 5′ Flanking Region of the Human Granzyme H Gene Directs Expression to T/Natural Killer Cell Progenitors and Lymphokine-Activated Killer Cells in Transgenic Mice (1999) (16)
Response and toxicity associated with dose escalation of arsenic trioxide in the treatment of resistant acute promyelocytic leukemia (1997) (16)
Recurrent DNMT3A Mutations In Patients with Myelodysplastic Syndrome (2010) (16)
Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. (2013) (16)
A-T-rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2. (1992) (16)
Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results from 24 Clones Derived from a Single C57BL/6 Mouse (2015) (15)
The pharmacology of hemoglobin switching: of mice and men. (1991) (15)
The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML (2013) (15)
Identification of somatic JAK 1 mutations in patients with acute myeloid leukemia (2008) (14)
Induction of hemoglobin F synthesis in patients with beta thalassemia. (1985) (14)
Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice (2012) (14)
Human globin gene expression in hybrid 2S MEL × human fibroblast cells (1984) (13)
Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence (2021) (13)
Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice. (2008) (13)
Reduced β‐Globin Gene Expression in Adult Mice Containing Deletions of Locus Control Region 5′ HS‐2 or 5′ HS‐3 a (1998) (13)
A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia. (2008) (13)
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. (2011) (13)
Use of protease proteomics to discover granzyme B substrates (2005) (12)
Differences in human alpha-, beta- and delta-globin gene expression in monkey kidney cells. (1982) (12)
AMD3100 Mobilizes Acute Promyelocytic Leukemia Cells from the Bone Marrow into the Peripheral Blood and Sensitizes Leukemia Cells to Chemotherapy. (2005) (11)
A weak upstream promoter gives rise to long human β-globin RNA molecules (1983) (11)
Mutation detection in thousands of acute myeloid leukemia cells using single cell RNA-sequencing (2018) (11)
Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms. (2005) (11)
Deletions within the mouse β-globin locus control region preferentially reduce βmin globin gene expression. (2000) (10)
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia (2022) (10)
Peptidase I Deficiency in Humans Consequences of Cathepsin C/Dipeptidyl Molecular, Cellular, and Clinical Papillon-Lefèvre Syndrome: Correlating the (2004) (9)
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome (2021) (9)
Mutational profiling in the human genome. (2003) (9)
The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. (1999) (9)
Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter. (1992) (9)
DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line (2018) (9)
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes. (2017) (9)
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells (2021) (9)
Targeted deletion of 5'HS2 of the murine fl-globin LCR reveals that it is. not essential for proper regulanon of the [ -globin locus (2007) (9)
Mcl 1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia (2010) (9)
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes (2021) (8)
Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2. (2007) (8)
Structure and function of the murine beta-globin locus control region 5' HS-3. (1992) (8)
Phase II Study of High Dose Lenalidomide as Initial Treatment for Older Acute Myeloid Leukemia Patients: Early Results Show a Significant Reduction of Bone Marrow Blasts after 14 Days of Therapy. (2007) (8)
Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy. (2018) (7)
Tumor suppressor function of Gata2 in Acute Promyelocytic Leukemia. (2021) (7)
High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin. (1988) (7)
Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia. (2009) (6)
Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia (2021) (5)
Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome (2016) (5)
Pharmacologic manipulation of fetal hemoglobin synthesis. (1985) (5)
CXCR4/SDF-1 Is a Key Regulator for Leukemia Migration and Homing to the BM: Impact of AMD3100 on In Vivo Response to Chemotherapy. (2006) (5)
DNMT3A R882H Overexpression Leads To Hematopoietic and Skin Alterations In Transgenic Mice (2013) (5)
DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults. (2021) (4)
Identification of Polymorphisms Associated with Susceptibility to Therapy-Related MDS and AML. (2007) (4)
Transcriptional Activation oftheHumanCytotoxic Serine Protease GeneCSP-BinT Lymphocytes (1990) (4)
Genomic landscapes and clonality of de novo AML. (2013) (4)
Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. (2001) (4)
Chelation therapy for transfusion-dependent adults. (1983) (4)
A weak upstream promoter gives rise to long human beta-globin RNA molecules. (1983) (3)
Recurrent transcriptional responses in AML and MDS patients treated with decitabine (2022) (3)
Dysregulation and Recurrent Mutation Of miRNA-142 In De Novo AML (2013) (3)
Recurrent Somatic Genomic Alterations in Follicular NHL (FL) Revealed By Exome and Custom-Capture Next Generation Sequencing (2015) (3)
Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia (2021) (3)
Abundance and structure of globin mRNA in K562 human leukemia cells. (1983) (3)
Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin (2014) (3)
Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression. (2000) (3)
Physician‐scientists in the United States at 2020: Trends and concerns (2022) (3)
5-AZACYTIDINE FOR BETA-THALASSAEMIA? (1983) (3)
Regulation of azurophil granule‐associated serine protease genes during myelopoiesis (1996) (3)
Decitabine in TP53-Mutated AML. (2017) (2)
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype (2021) (2)
Expression of PML-RARα by the Murine PML Locus Leads to Myeloid Self-Renewal, Clonal Expansion and Morphologic Promyelocytic Leukemia. (2008) (2)
Preliminary results of a phase II study of high dose lenalidomide as initial therapy for acute myeloid leukemia in patients ≥ 60 years old (2008) (2)
tyrosine kinase genes of patients with de novo acute myeloid leukemia Somatic mutations and germline sequence variants in the expressed (2013) (2)
Genomic DNA Copy Number Alterations Present in AML Bone Marrow Samples with Normal Cytogenetics. (2004) (2)
Subclonal Evolution Characterizes MDS Disease Progression Following Allogeneic Stem Cell Transplant (2017) (2)
Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression. (2022) (2)
Function of Transfected Globin Promoters and the Globin Locus Activator in K562 Erythroleukemia Cells a (1990) (2)
IL-12 Stimulates Interferon-Gamma Mediated Inhibition of Tumor-Induced Regulatory T Cell Proliferation and Enhances Tumor Clearance (2008) (2)
The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes. (2007) (2)
Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes (2011) (2)
Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations (2013) (2)
Induction of fgr proto-oncogene mRNA in B lymphocytes as a consequence of Epstein-Barr virus infection. (1986) (2)
Augmentation of hemoglobin synthesis by S-phase specific drugs in the K562 cell line. (1985) (2)
Immune Escape of AML Cells after Transplantation. Reply. (2019) (2)
Obesity As a Risk Factor for Acute Promyelocytic Leukemia. Results from Population and Case-Control Studies Across Western Countries and Correlation with Gene Expression in the TCGA (2016) (2)
Whole Exome Sequencing Reveals the Order of GeneticChangesduringMalignantTransformation and Metastasis in a Single Patient with NF 1-plexiform Neuro fi broma (2015) (2)
Downregulation of MHC Class II in Relapsed AML Cells after Allogeneic Transplantation (2017) (1)
Stanley Joel Korsmeyer (1950-2005) (2005) (1)
Functional Hematopoietic Cells Derived From Mouse Embryonic Stem Cells. (2012) (1)
Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing. (2009) (1)
Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells (2022) (1)
A transient assay system to study gamma globin gene expression in K562 cells. (1987) (1)
Rare Hematopoietic Subclones Harboring Leukemogenic TP53 Mutations Are Detectable Via Error-Corrected Sequencing in Healthy Elderly Individuals (2014) (1)
Post-Genomic Technologies (2007) (1)
Tumor suppressor function of WT1 in acute promyelocytic leukemia. (2021) (1)
Sequencing an Acute Myeloid Leukemia (AML) Genome with “Next Generation” Technologies. (2007) (1)
Dynamic Changes in Clonal Clearance with Decitabine Therapy in AML and MDS Patients (2015) (1)
DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice (2014) (1)
Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes (1990) (1)
The NK Cell MicroRNA Transcriptome Defined by Next-Generation Sequencing Identifies IL-15-Signaled Alterations In Mature MiR-223 Expression, and MiR-223 as a Potential Regulator of Murine Granzyme B (2010) (1)
Reviewers for the Journal, January-June 2016. (2016) (1)
Silent " nucleotide substitution in a , B-thalassemia globin gene activates splice site in coding sequence RNA ( RNA processing / mRNA / expression vector / gene cloning / mutation ) (1)
Functional Early Hematopoietic Progenitor Cells Derived From Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells (2013) (1)
Detection of Novel Mutations In MDS/AML by Whole Genome Sequencing (2010) (1)
DNMT3A-Dependent DNA Methylation May Act As a Tumor Suppressor-Not a Tumor Promoter-during AML Progression (2016) (1)
Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy (2022) (1)
The unique roles of murine granzymes (Gzm) A and B for NK-dependent tumor cell killing and regulatory T cell control of NK cells (2006) (1)
1998 ASCI Presidential Address. (2003) (1)
Association BetweenMutation Clearance After Induction Therapy andOutcomes in AcuteMyeloid Leukemia (2015) (1)
In vivo bioluminescence imaging of acute promyelocytic leukemia cell trafficking and mobilization by AMD3100 (2006) (1)
Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes (2010) (1)
MIR142 Loss-of-Function Mutations Promote Leukemogenesis through Derepression of ASH1L Resulting in Increased HOX Gene Expression (2016) (1)
"Silent" nucleotide substitution in codon 24 of a beta+ thalassemia globin gene activates splice site in coding sequence RNA. (1983) (1)
BreakTrans: uncovering the genomic architecture of gene fusions (2013) (1)
Development of a Retractable Bone Probe Using Shape Memory Alloys (1991) (1)
IL-1b expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function. (2022) (1)
Globin gene expression in somatic cell hybrids. (1983) (1)
Differential Regulation of Granzyme B and C Expression in Murine Cytotoxic T and NK Cells. (2007) (1)
Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia (2012) (1)
Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia.Â Â (2017) (1)
Characterization of snoRNA Expression in Acute Myeloid Leukemia (2015) (1)
Transcriptional regulation of human gamma globin gene expression. (1989) (1)
The Molecular Basis of Long First Remissions in Normal Karyotype AML Patients (2019) (0)
leukemia Identification of somatic JAK1 mutations in patients with acute myeloid (2013) (0)
DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line (2018) (0)
A Comprehensive Reassessment of the Direct DNA Binding Sites of PML-Rara within the Genomes of Primary Hematopoietic Progenitor Cells, and Their Effects on Chromatin Structure and Gene Expression (2022) (0)
Title: Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia Authors and Affiliations: (2021) (0)
SignaturesModel-Dependent Progression Promyelocytic Leukemia Cells Reveals Expression Profiling of Murine Acute (2014) (0)
Genomic landscape of TP53-mutated myeloid malignancies (2023) (0)
Evidence for Complete Mutation Clearance in Normal Karyotype AML Patients with Very Long (> 5 years) Remissions after Chemotherapy Alone (2018) (0)
Molecular Profiling of Decitabine Response in MDS and AML Patients (2020) (0)
Molecular defects in beta-thalassemia. (1982) (0)
Cytotoxic Lymphocyte Functions Granzymes C and/or F Are Important for Granzyme B and the Downstream (2005) (0)
Activation of Notch Signaling Is An Early Event in the Development of PML-Rara-Induced Acute Promyelocytic Leukemia (APL) (2011) (0)
Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA (2013) (0)
POU4F1 Is Associated with t(8;21) AML and Contributes Directly to Its Unique Transcriptional Signature. (2009) (0)
Multilineage Expansion of Lymphoid and Myeloid Cells in Mice Expressing PML-RARα under the Control of the Murine Cathepsin G Locus. (2006) (0)
Abstract LB-232: Tumor clonality detection using next generation sequencing data. (2013) (0)
murine promyelocytic leukemia in hCG-PML/RARA transgenic mice Quantitative trait loci associated with susceptibility to therapy-related acute (2013) (0)
arising in the setting of severe congenital neutropenia Distinct patterns of mutations occurring in de novo AML versus AML (2013) (0)
Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice (2013) (0)
Multiplexed Digital Quantification of mRNA Abundance: a Highly Reproducible, PCR–independent Assessment of BAALC , ERG , and MN1 mRNA Levels in Acute Myeloid Leukemia (AML) Bone Marrow (BM) and Peripheral Blood (PB) Samples. (2009) (0)
Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera (2022) (0)
LB1135 Altered cell populations in Dnmt3a-deficient murine epidermis (2019) (0)
High Resolution Array-Based CGH and SNP Studies of AML Genomes. (2007) (0)
Abstract 4867: Identification of an inv(16)-encodedCBFA2T3-GLIS2fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project (2012) (0)
Improved stent Konfgurationen (1998) (0)
Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance (2018) (0)
Physician-Scientist Training--Reply (2006) (0)
expandable and longitudinally flexible stent. (1999) (0)
Gata2 Expression and Function in PML-RARA-driven Preleukemia and APL (2019) (0)
DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia (2010) (0)
result in an unstable predictive model. How highly corre- lated are these variables, and what might be the impact on generalizability? (2016) (0)
expression α very low levels of PML-RAR High-penetrance mouse model of acute promyelocytic leukemia with (2013) (0)
Abstract A1-13: Ultra-deep whole-genome sequencing reveals clinically relevant low-frequency subclones in an acute myeloid leukemia (2015) (0)
Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions. (2022) (0)
Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Geno (2011) (0)
The AML Genome(s) (2014) (0)
Retrospective: Stanley Joel Korsmeyer (1950-2005). (2005) (0)
Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults (2021) (0)
1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis (2018) (0)
How Do Lymphocytes Kill Tumor Cells ? 1 (2005) (0)
Genetic Susceptibility to Therapy-Related Acute Murine Promyelocytic Leukemia. (2007) (0)
Reprogramming of Leukemic and Pre-Leukemic Cells from Primary Human De Novo Acute Myeloid Leukemia Samples into Induced Pluripotent Stem (iPS) Cells (2015) (0)
Premature Senescence Responses, and the Prevention of Development, Optimal Cellular Stress YB-1 Is Important for Late-Stage Embryonic (2014) (0)
DNMT3A R882H Can Cooperate with FLT3-ITD to Cause AML in Mice (2015) (0)
Granzyme B Is Important for Treg-Mediated Suppression of NK-Dependent Tumor Clearance In Vivo . (2006) (0)
242 Genomics of myelodysplastic syndromes (2011) (0)
DNA methylation and regulation of the human f 3-globin-like genes in mouse erythroleukemia cells containing human chromosome 11 ( 5-azacytidine / hypomethylation / gene regulation ) (0)
The Protein Interactome of DNMT3A, and Altered Interactions Caused By Missense Mutations Associated with AML and/or the DNMT3A Overgrowth Syndrome (2022) (0)
Visualizing tumor evolution with the fishplot package for R (2016) (0)
Cellular Stressors Contribute to the Expansion of Multiple Hematopoietic Clones of Varying Leukemic Potential (2017) (0)
The Effect of Rara Haploinsufficiency in a Mouse Model of Acute Promyelocytic Leukemia. (2009) (0)
IDENTIFICATION OF DEFECTIVE GLOBIN mRNA IN MEL × FIBROBLAST HYBRID CELLS (1982) (0)
Myeloproliferative Disease and Myeloid Leukemia in Dnmt3a Haploinsufficient Mice (2014) (0)
Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara (2014) (0)
Increased ROS Stress and Alterations in the Bone Marrow Microenvironment Contribute to DNA Damage in Hematopoietic Stem/Progenitors Carrying a Csf3r Truncation Mutation. (2009) (0)
Commonly dysregulated genes in murine APL cells. Commentary (2007) (0)
Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse (2012) (0)
Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia (2012) (0)
DNA Sequencing of a Murine Acute Promyelocytic Leukemia (APL) Genome Using Next Generation Technology. (2009) (0)
Comparison of Medical Device Design Alternatives Using the Mechanical Properties of NiTi Alloys (1991) (0)
Regulatory regions flanking the human fetal gamma-globin genes. (1989) (0)
Abstract PL03-02: The AML genome(s) (2016) (0)
Latent Murine Herpesvirus-4 Infection Arms NK Cells. (2009) (0)
Murine NK Cells Require Activation-Dependent Expression of Granzyme B and Perforin To Become Potent Cytotoxic Effectors. (2006) (0)
Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression (2021) (0)
Transcriptome Analysis of Murine Myeloid Development. (2005) (0)
Regulatory Regions Flanking the Human Fetal γ‐Globin Genes (1989) (0)
Gene: A Premature Termination (2017) (0)
Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Cytoreductive Chemotherapy in Adult De Novo AML Patients (2015) (0)
Abstract 3878: A model to assess clonal evolution of metastatic colorectal cancer during chemotherapy utilizing patient derived xenografts (2015) (0)
Brief Expression of a bcr-1 isoform of RAR (cid:1) -PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2 (2007) (0)
5-AZACYTIDINE FOR BETA-THALASSAEMIA? (1983) (0)
Early Myeloid Cells Activities in α PML-Retinoic Acid Receptor Neutrophil Elastase Is Important for (2014) (0)
microRNA transcriptome Next-generation sequencing identifies the natural killer cell Material (2016) (0)
Loss-of-Function Mutations of MIR142 May Contribute to Leukemogenesis By Expanding the Pool of Myeloid-Biased HSCs (2015) (0)
2. Demographics of the Physician-Scientist Workforce: Impact of Age, Gender, Degrees, and Debt (2016) (0)
Dnmt3a Inactivation Leads to Slow DNA Methylation Loss in Murine Hematopoietic Cells In Vivo (2021) (0)
Identification of PML-RARa Target Genes Using Microarray and ChIP-on-Chip Analysis. (2005) (0)
Commonly Dysregulated Genes in Murine Acute Promyelocytic Leukemia (APL) Cells. (2006) (0)
Longitudinal Flexible and expandable stent (1999) (0)
Specific Patterns of DNA Remethylation in the Bone Marrow Cells of Dnmt3a Deficient Mice after Induced Expression of Wild Type Human DNMT3A (2015) (0)
Clonal Evolution of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation (2016) (0)
Characterization of the microRNAome in a patient with acute myeloid leukemia. (2010) (0)
Resolution of a Clinical Dilemma with Whole Genome Sequencing, and Discovery of a New Mechanism for Generating PML-Rara: Insertional Fusion (2010) (0)
Whole-Genome Sequencing and Acute Promyelocytic Leukemia—Reply (2011) (0)
Inactiviation of the Histone H3K27 Demethylase UTX/KDM6A Gene Cooperates with Activated KRAAS in a Lung Carcinogenisis Model Evaluated by MicroPET-CT Imaging (2015) (0)
Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing. (2023) (0)
R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A (2013) (0)
Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia (2010) (0)
Sequencing Acute Myeloid Leukemia Genomes with “Next Generation” Technologies. (2008) (0)
DNMT 3 AR 882-associated hypomethylation patterns are maintained in primary AML xenografts , but not in the DNMT 3 AR 882 C OCI-AML 3 leukemia cell line (2019) (0)
DNMT3AR882 Alters the Epigenome of Hematopoietic Cells (2019) (0)
Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing (2022) (0)
Clonal Evolution and Relapse in Adult De Novo Acute Myeloid Leukemia (2017) (0)
Abstract 169: Metastatic colorectal cancer associated long non-coding RNAs identified by transcriptome sequencing of matched primary and metastatic patient tissues (2015) (0)
Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia. (2007) (0)
Abstract A1-44: Clinical cancer sequencing and integrated analysis of whole genomes, exomes and transcriptomes (2015) (0)
The De Novo DNA Methylation Activity of WT DNMT3A Is Inhibited by R882H DNMT3A and DNMT3B3 in Vitro (2012) (0)
The Protein Interactomes of CBFB-MYH11 and RUNX1-RUNX1T1 Suggest Different Mechanisms of Action for Initiating Acute Myeloid Leukemia (2022) (0)
Physician-scientist training. Authors' reply (2006) (0)
Erratum: The Pediatric Cancer Genome Project (2012) (0)
Re-Sensitization of Allogeneic T Cell Resistant Murine AML with Pegylated IFN-Gamma (2022) (0)
Single-cell RNA-sequencing Reveals Transcriptional Changes and Clonal Architecture associated with Post-Transplant Relapse in Acute Myeloid Leukemia (2020) (0)
Abstract LB-423: Whole genome comparisons of pre- and post- aromatase inhibitor treatment in estrogen receptor positive breast cancer (2012) (0)
Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma (2012) (0)
RNA processing errors in patients with , 8 thalassemia ( Si nuclease mapping / M 13 phage / splicing ) (0)
The Cold-Shock Domain Protein YB-1 Is Important for Cellular Proliferation and the Prevention of Premature Senescence. (2004) (0)
G-CSFSR Mutations Present in Patients with Severe Congenital Neutropenia Cooperate with PML-RARα To Induce Acute Myeloid Leukemia in Mice. (2007) (0)
Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity (2018) (0)
MYC Influences mRNA Processing and Nuclear Export to Initiate Acute Myeloid Leukemia (2022) (0)
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential (2018) (0)
Signaling Gene Mutations Are Characterized By Diverse Patterns of Expansion and Contraction during Progression from MDS to Secondary AML (2020) (0)
Orphan Granzymes Downstream from Granzyme B Are Important for Tumor Clearance In Vivo and in Vitro. (2004) (0)
Next-Generation Sequencing: A Discovery Tool for Blood Disorders (2012) (0)
Dynamic Changes in MDS Clonal Architecture Following Allogeneic Stem Cell Transplant (2016) (0)
Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples (2021) (0)
Neutrophil Elastase Is Important for Several Activities of PML-RARα in Early Myeloid Cells. (2004) (0)
Detection of Clonal Hematopoiesis in Cytopenic Patients Using Targeted Sequencing (2015) (0)
680 A common acute myeloid leukemia-associated DNMT3A mutation, when expressed ubiquitously in mice, causes reversible alopecia (2016) (0)
Abstract 4109: Clonal evolution of metastatic colorectal cancer (2015) (0)
Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML (2019) (0)
Analgesics and NSAID . Molecular genetics . Methods for evaluating psychotherapeutic drugs (1985) (0)
In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples. (2012) (0)
Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples (2020) (0)
Detection of Microdeletions and Amplifications in Primary Human Acute Myeloid Leukemia (AML) Genomes Using Ultradense Oligomer Tiling Path Arrays and Comparative Genomic Hybridization (CGH). (2005) (0)
Analysis of Mice Containing a Targeted Deletion of (cid:98) -Globin Locus Control Region 5 (cid:57) Hypersensitive Site 3 (1996) (0)

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