Timothy A. Springer

Timothy A. Springer's AcademicInfluence.com Rankings

Timothy A. Springer

Biology

#663

World Rank

#1166

Historical Rank

#369

USA Rank

Immunology

World Rank

#10

Historical Rank

USA Rank

biology Degrees

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Biology

Timothy A. Springer's Degrees

Doctorate Medicine University of Chicago
PhD Biochemistry University of Chicago

Why Is Timothy A. Springer Influential?

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According to Wikipedia, Timothy "Tim" A. Springer is an immunologist and the Latham Family Professor at Harvard Medical School. He is also a professor at the Department of Biological Chemistry and Molecular Pharmacology and of the Division of Medical Sciences, and a Senior Investigator at the Research Program in Cellular and Molecular Medicine of the Boston Children's Hospital. Springer is best known for discovering the first integrins, LFA-1, and intercellular adhesion molecules , and for elucidating how these cell adhesion molecules function in the immune system. In recent years, Springer's research interest has expanded to malaria, transforming growth factor beta signaling, and von Willebrand factor.

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Timothy A. Springer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm (1994) (7502)
Adhesion receptors of the immune system (1990) (6621)
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). (1986) (2481)
Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins (1991) (2253)
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry (1996) (2106)
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1) (1987) (1749)
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. (1998) (1726)
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. (1995) (1649)
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 (1989) (1642)
Structural basis of integrin regulation and signaling. (2007) (1618)
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) (1996) (1615)
The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood (1997) (1485)
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. (1986) (1469)
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. (1986) (1438)
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. (1994) (1199)
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling (2002) (1159)
Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody (1979) (1129)
The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. (1987) (1115)
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. (1987) (1111)
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. (1997) (1006)
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells (1988) (974)
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families (1988) (968)
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. (1988) (934)
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18) (1990) (914)
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1 (1989) (894)
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins (2003) (839)
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics (2004) (829)
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses (1989) (804)
Latent TGF-β structure and activation (2011) (799)
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1 (1995) (794)
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation (1991) (794)
A human leukocyte differentiation antigen family with distinct alpha- subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule (1983) (749)
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. (1982) (742)
Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. (1996) (737)
The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. (1999) (731)
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus (1990) (718)
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them (2004) (674)
Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1) (1988) (634)
Structure and Function of Leukocyte Integrins (1990) (615)
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells (1988) (599)
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor (1982) (596)
The genome of M. acetivorans reveals extensive metabolic and physiological diversity. (2002) (573)
The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. (1983) (572)
High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. (1995) (571)
The I domain is a major recognition site on the leukocyte integrin Mac- 1 (CD11b/CD18) for four distinct adhesion ligands (1993) (566)
Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. (1991) (563)
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen (1993) (563)
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens (1978) (561)
Integrin avidity regulation: are changes in affinity and conformation underemphasized? (2003) (554)
A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. (1981) (552)
Conformational regulation of integrin structure and function. (2002) (552)
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. (1996) (547)
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1 (1991) (542)
Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. (1996) (538)
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice (1994) (519)
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation (2003) (509)
Transcellular diapedesis is initiated by invasive podosomes. (2007) (499)
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. (2008) (496)
The dynamic regulation of integrin adhesiveness (1994) (494)
The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester (1986) (486)
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. (2001) (486)
Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis (1984) (478)
Cloning of the β subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family (1987) (473)
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes (1992) (465)
Adhesion through L-selectin requires a threshold hydrodynamic shear (1996) (460)
Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface. (1987) (454)
Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones (1986) (451)
The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3 (1987) (439)
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. (2004) (438)
The leukocyte integrins. (1989) (428)
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow (1995) (422)
Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. (1987) (422)
Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies. (1982) (417)
Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain (1997) (415)
Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity (1988) (405)
Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. (1984) (403)
Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor (2009) (400)
Integrin activation and structural rearrangement (2002) (400)
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow (1995) (400)
Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. (1986) (397)
Sticky sugars for selectins (1991) (397)
The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria (1988) (375)
The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling (1997) (371)
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. (1997) (358)
Neutrophils roll on E-selectin. (1993) (348)
Integrin inside-out signaling and the immunological synapse. (2012) (343)
Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. (1996) (342)
Therapeutic antagonists and conformational regulation of integrin function (2003) (338)
Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency (1987) (334)
Association of intercellular adhesion molecule-1 (ICAM-1) with actin- containing cytoskeleton and alpha-actinin (1992) (327)
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation (2002) (327)
Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity (1988) (322)
Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules (1996) (316)
THE SMALL SUBUNIT OF HL-A ANTIGENS IS β2-MICROGLOBULIN (1973) (315)
Structure of integrin α5β1 in complex with fibronectin (2003) (305)
B Lymphocyte Chemotaxis Regulated in Association with Microanatomic Localization, Differentiation State, and B Cell Receptor Engagement (1998) (298)
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1) (1995) (296)
Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing. (1981) (296)
Integrin structures and conformational signaling. (2006) (290)
A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection (1990) (289)
IL-8 Production in Human Lung Fibroblasts and Epithelial Cells Activated by the Pseudomonas Autoinducer N-3-Oxododecanoyl Homoserine Lactone Is Transcriptionally Regulated by NF-κB and Activator Protein-21 (2001) (284)
Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. (1981) (283)
Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation. (1986) (282)
Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils. (1993) (281)
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily (1989) (277)
Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. (2006) (274)
Sequence and structure relationships within von Willebrand factor. (2012) (273)
A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure. (1981) (273)
Mapping of antigenic and functional epitopes on the alpha- and beta- subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1 (1983) (269)
Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. (2002) (267)
The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2 (2004) (264)
Chemoattractant-regulated mobilization of a novel intracellular compartment in human neutrophils. (1987) (259)
Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit. (1991) (258)
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site (1991) (258)
The chemokine receptor CXCR3 mediates rapid and shear‐resistant adhesion‐induction of effector T lymphocytes by the chemokines IP10 and Mig (1998) (252)
Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion (1987) (251)
A mechanically stabilized receptor–ligand flex-bond important in the vasculature (2010) (250)
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. (1988) (246)
T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies. (1986) (244)
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B. (1988) (244)
A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. (1994) (241)
Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family. (1989) (239)
Changes in subcellular localization and surface expression of L‐selectin, alkaline phosphatase, and Mac‐1 in human neutrophils during stimulation with inflammatory mediators (1994) (239)
Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. (1981) (238)
cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. (1987) (236)
LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation. (1984) (236)
Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1 Engagement of Leukocyte LFA-1 1 (2003) (230)
An Automatic Braking System That Stabilizes Leukocyte Rolling by an Increase in Selectin Bond Number with Shear (1999) (230)
Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. (1983) (229)
C-terminal opening mimics 'inside-out' activation of integrin α5β1 (2001) (227)
Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow (1996) (225)
The Relative Weight Index in Fisheries Management: Status and Needs (1991) (225)
Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo (2001) (224)
Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils (1987) (223)
LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function 1 (1982) (222)
Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area (1996) (220)
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair (2001) (217)
C‐C chemokines, but not the C‐X‐C chemokines interleukin‐8 and interferon‐γ inducible protein‐10, stimulate transendothelial chemotaxis of T lymphocytes (1995) (216)
Structural Biology and Evolution of the TGF-β Family. (2016) (214)
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis (1996) (214)
A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand (2004) (211)
Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2 (1991) (210)
Supergene families meet in the immune system. (1988) (209)
Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3 (2008) (208)
Evaluation of the Relative Weight (Wr ) Index, with New Applications to Walleye (1990) (208)
Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface (1987) (208)
von Willebrand factor, Jedi knight of the bloodstream. (2014) (200)
Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens. (1987) (200)
The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes (1996) (200)
Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains (2001) (199)
A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. (1998) (195)
Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation1 (2001) (194)
Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus (1992) (193)
Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model. (2001) (191)
Trans-cellular migration: cell-cell contacts get intimate. (2008) (190)
Complete integrin headpiece opening in eight steps (2013) (190)
Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. (1974) (188)
Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction (2004) (187)
Structure of an integrin with an αI domain, complement receptor type 4 (2010) (186)
Force interacts with macromolecular structure in activation of TGF-β (2017) (185)
Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. (1997) (184)
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor (2009) (184)
Deficiency of a surface membrane glycoprotein (Mo1) in man. (1984) (184)
Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State* (2001) (180)
Leukocyte adhesion deficiency: molecular basis and functional consequences. (1988) (180)
Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils. (1996) (180)
An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. (1998) (178)
Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses (1994) (178)
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor (2010) (177)
A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1) (*) (1995) (177)
Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules (1995) (175)
Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses (1998) (175)
Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells (1978) (172)
Multiple integrins share the ability to induce elevation of intracellular pH. (1991) (172)
Expression and Polarization of Intercellular Adhesion Molecule-1 on Human Intestinal Epithelia: Consequences for CD11b/CD18-Mediated Interactions with Neutrophils (1996) (170)
Residues within a conserved amino acid motif of domains 1 and 4 of VCAM- 1 are required for binding to VLA-4 (1994) (168)
The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. (1997) (167)
The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. (2004) (166)
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. (2005) (165)
Regulation of integrin affinity on cell surfaces (2011) (164)
GARP regulates the bioavailability and activation of TGFβ (2012) (163)
The sensation and regulation of interactions with the extracellular environment: the cell biology of lymphocyte adhesion receptors. (1990) (162)
Intercellular adhesion molecule‐1‐deficient mice are less susceptible to cerebral ischemia‐reperfusion lnjury (1996) (162)
Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. (1982) (161)
Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (1995) (160)
LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells (1986) (158)
Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labeling and electron microscopy. (1996) (155)
Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency. (1984) (154)
Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow (1994) (153)
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster (2003) (152)
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand (2003) (151)
Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. (1999) (151)
Tissue distribution, structural characterization, and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity. (1983) (151)
Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium. (1991) (148)
A HUMAN LEUKOCYTE DIFFERENTIATION ANTIGEN FAMILY WITH DISTINCT a-SUBUNITS AND A COMMON 3- SUBUNIT: (1983) (147)
Computational design of an integrin I domain stabilized in the open high affinity conformation (2000) (147)
Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing1 (2001) (145)
An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond (2001) (145)
Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium (1992) (144)
CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma (1996) (142)
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration (2008) (141)
Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). (1989) (141)
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. (2009) (140)
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. (2003) (139)
Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin. (1994) (137)
Importance of force linkage in mechanochemistry of adhesion receptors. (2006) (137)
Cell-Surface Differentiation in the Mouse (1980) (136)
Coordinated integrin activation by actin-dependent force during T-cell migration (2016) (135)
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics (2016) (134)
Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells (2012) (134)
Structural transitions of complement component C3 and its activation products (2006) (134)
P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. (1997) (133)
Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface (1997) (133)
Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. (1999) (131)
Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions. (1995) (131)
Modulation of Endothelial Cell Adhesion by Hevin, an Acidic Protein Associated with High Endothelial Venules (*) (1996) (130)
Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor (1987) (130)
Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM‐1 in shear flow (1995) (130)
Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein (1987) (128)
Complex between nidogen and laminin fragments reveals a paradigmatic β-propeller interface (2003) (128)
Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. (1997) (125)
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. (1988) (124)
Flow-induced elongation of von Willebrand factor precedes tension-dependent activation (2017) (123)
Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors. (1992) (123)
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. (1994) (121)
Purification and structural characterisation of human HLA-linked B-cell antigens (1977) (121)
On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules. (1990) (119)
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor (2011) (119)
p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family. (1986) (119)
Archaeal Surface Layer Proteins Contain β Propeller, PKD, and β Helix Domains and Are Related to Metazoan Cell Surface Proteins (2002) (118)
Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3) (1987) (118)
Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling (2007) (117)
The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. (1998) (116)
Specialized functional properties of the integrin alpha 4 cytoplasmic domain. (1995) (115)
Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2 (2010) (114)
A pH‐regulated dimeric bouquet in the structure of von Willebrand factor (2011) (114)
Lymphokine inducing "terminal differentiation" of the human monoblast leukemia line U937: a role for gamma interferon. (1983) (113)
Leukocyte adhesion deficiency. Aberrant splicing of a conserved integrin sequence causes a moderate deficiency phenotype. (1989) (112)
The importance of the Mac-1, LFA-1 glycoprotein family in monocyte and granulocyte adherence, chemotaxis, and migration into inflammatory sites: insights from an experiment of nature. (1986) (112)
Integrin extension enables ultrasensitive regulation by cytoskeletal force (2017) (110)
Transition From Rolling to Firm Adhesion Is Regulated by the Conformation of the I Domain of the Integrin Lymphocyte Function-associated Antigen-1* (2002) (110)
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. (2004) (109)
Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates (1990) (109)
Hybridoma Technology in the Biosciences and Medicine (2012) (109)
Remodeling of the lectin–EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force (2006) (108)
Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1 (1993) (105)
Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions (1996) (105)
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. (2010) (105)
Structural basis for dimerization of ICAM-1 on the cell surface. (2004) (105)
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System (2018) (105)
Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18) (1992) (104)
Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils. (1997) (104)
Overlapping and Selective Roles of Endothelial Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 in Lymphocyte Trafficking 1 (2003) (104)
Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. (2008) (103)
Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface. (1981) (103)
The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength. (1997) (103)
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. (2004) (102)
Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration. (1998) (101)
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. (2004) (101)
Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain. (2000) (100)
Structural determinants of integrin β-subunit specificity for latent TGF-β (2014) (99)
Structure of bone morphogenetic protein 9 procomplex (2015) (99)
Conformational equilibria and intrinsic affinities define integrin activation (2017) (98)
Relating conformation to function in integrin α5β1 (2016) (98)
Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides* (2004) (97)
The critical cytoplasmic regions of the αL/β2 integrin in Rap1-induced adhesion and migration (2003) (96)
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion (1988) (96)
The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. (1998) (96)
Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. (1997) (96)
Modelling animal movement as a persistent random walk in two dimensions: expected magnitude of net displacement (2000) (95)
Monoclonal antibodies specific for rat IgG1, IgG2a, and IgG2b subclasses, and kappa chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies. (1982) (94)
Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. (1990) (94)
Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region. (1976) (94)
Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. (1995) (93)
Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface. (1998) (91)
Unexpected fold in the circumsporozoite protein target of malaria vaccines (2012) (91)
The intracellular bacterium Rhodococcus equi requires Mac-1 to bind to mammalian cells (1993) (88)
Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1* (2000) (88)
Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules (1993) (88)
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αxβ2 (2005) (87)
Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1. (1985) (86)
Characterization of an anti-H-2 monoclonal antibody and its use in large-scale antigen purification. (1981) (85)
Identification of cell surface antigens present on murine hematopoietic stem cells. (1985) (84)
A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow. (1996) (84)
Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing (1982) (83)
Characterization of transendothelial chemotaxis of T lymphocytes. (1995) (83)
Structure and allosteric regulation of the αXβ2 integrin I domain (2003) (82)
Kinetics and Thermodynamics of Virus Binding to Receptor. (1995) (82)
Allosteric β1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain* (2004) (82)
Folding of the β-propeller domain of the integrin αL subunit is independent of the I domain and dependent on the β2 subunit (1997) (82)
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots (2007) (81)
Complement and the multifaceted functions of VWA and integrin I domains. (2006) (81)
Antigens involved in mouse cytolytic T-lymphocyte (CTL)-mediated killing: functional screening and topographic relationship. (1982) (81)
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. (2006) (80)
Sequential Regulation of ct4131 and ct5131 Integrin Avidity by CC Chemokines in Monocytes: Implications for Transendothelial Chemotaxis (1996) (80)
Structural specializations of α4β7, an integrin that mediates rolling adhesion (2012) (80)
Amino Acid Residues in the αIIb Subunit That Are Critical for Ligand Binding to Integrin αIIbβ3 Are Clustered in the β-Propeller Model* (2001) (79)
C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. (2001) (79)
Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. (1986) (79)
Does Atrazine Influence Larval Development and Sexual Differentiation in Xenopus laevis? (2008) (79)
LFA-1 Expression on Target Cells Promotes Human Immunodeficiency Virus Type 1 Infection and Transmission (2001) (78)
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds (2013) (78)
Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3 (1989) (78)
Natural killer cell and granulocyte Fc gamma receptor III (CD16) differ in membrane anchor and signal transduction. (1989) (76)
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion (2001) (76)
Interaction of West Nile virus with primary murine macrophages: role of cell activation and receptors for antibody and complement (1986) (76)
Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. (1987) (76)
Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released (1994) (75)
Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function. (1983) (75)
Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptor. (1982) (73)
Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity. (1983) (73)
Tests of the Extension and Deadbolt Models of Integrin Activation* (2007) (72)
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions (2016) (72)
Modifying the mechanical property and shear threshold of L-selectin adhesion independently of equilibrium properties (1998) (72)
Ultrastructure and Function of Dimeric, Soluble Intercellular Adhesion Molecule-1 (ICAM-1)* (2001) (72)
Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association. (1977) (72)
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration (2017) (71)
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2 (2013) (71)
Tenascin Supports Lymphocyte Rolling (1997) (71)
Structure-Guided Design of a High-Affinity Platelet Integrin αIIbβ3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS (2012) (71)
Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells. (1997) (71)
Contribution of N-Linked Glycans to the Conformation and Function of Intercellular Adhesion Molecules (ICAMs)* (2005) (71)
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2 (2005) (71)
Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds (2002) (70)
Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70). (1981) (70)
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. (2004) (70)
The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated. (1990) (70)
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. (2014) (70)
Expression and induction in vitro of macrophage differentiation antigens on murine cell lines. (1983) (70)
Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. (1996) (69)
Transendothelial chemotaxis of human αβ and γδ T lymphocytes to chemokines (1998) (69)
Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are interdependent for cell surface expression. (1997) (69)
Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin (1996) (68)
Maturation decreases responsiveness of human bone marrow B lineage cells to stromal‐derived factor 1 (SDF‐1) (1999) (68)
Shape change in the receptor for gliding motility in Plasmodium sporozoites (2012) (68)
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. (2002) (68)
Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins. (1988) (67)
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits (2001) (67)
Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins (1987) (67)
Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor* (2012) (67)
Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. (2004) (67)
Two-dimensional Kinetics Regulation of αLβ2-ICAM-1 Interaction by Conformational Changes of the αL-Inserted Domain* (2005) (66)
Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions (2004) (66)
Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules (1992) (66)
Structural basis for selectin mechanochemistry (2009) (65)
α(V)β(3) integrin crystal structures and their functional implications. (2012) (64)
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. (2002) (63)
L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules (1998) (63)
The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes. (1996) (63)
Metal ion and ligand binding of integrin α5β1 (2014) (63)
Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib* (2014) (63)
Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. (1990) (63)
Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC. (2002) (62)
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes (2006) (62)
Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1 (1985) (62)
Folding of the conserved domain but not of flanking regions in the integrin β2 subunit requires association with the α subunit (1997) (62)
Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. (2014) (62)
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. (2011) (61)
Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. (1992) (61)
The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. (1998) (61)
Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon (1985) (61)
Purified lymphocyte function‐associated antigen‐3 and T11 target structure are active in CD2‐mediated T cell stimulation (1987) (60)
Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding (2012) (60)
Partial purification of detergent-soluble HL-A antigen and its cleavage by papain. (1974) (60)
Amino Acid Residues in the PSI Domain and Cysteine-rich Repeats of the Integrin β2 Subunit That Restrain Activation of the Integrin αxβ2 * (2001) (60)
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus (2017) (60)
Intact αIIbβ3 Integrin Is Extended after Activation as Measured by Solution X-ray Scattering and Electron Microscopy* (2011) (59)
Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion* (2006) (59)
The HIV coreceptors CXCR 4 and CCR 5 are differentially expressed and regulated on human T lymphocytes (1997) (58)
The chemokine receptor CXCR 3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP 10 and Mig (1998) (58)
Properties of Relative Weight and other Condition Indices (1990) (58)
Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells. (1983) (58)
The Structure of the β-Propeller Domain and C-terminal Region of the Integrin αM Subunit (1998) (58)
Boca‐dependent maturation of β‐propeller/EGF modules in low‐density lipoprotein receptor proteins (2004) (57)
Transition from Rolling to Firm Adhesion Can Be Mimicked by Extension of Integrin αLβ2 in an Intermediate Affinity State* (2006) (57)
Characterization of murine intercellular adhesion molecule-2. (1996) (57)
The Chemokine Receptor CXCR 4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone (1999) (55)
Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1. (1985) (55)
How Natalizumab Binds and Antagonizes α4 Integrins* (2013) (55)
Internalization of a major group human rhinovirus does not require cytoplasmic or transmembrane domains of ICAM-1. (1992) (55)
Subcellular Localization and Dynamics of Mac-1 ( amfi 2 ) in Human Neutrophils (55)
Localization of the Binding Site on Intercellular Adhesion Molecule-3 (ICAM-3) for Lymphocyte Function-associated Antigen 1 (LFA-1)* (1996) (55)
Mechanisms of tumor cell capture by activated macrophages: evidence for involvement of lymphocyte function-associated (LFA)-1 antigen. (1986) (55)
Studies on antigens associated with the activation of murine mononuclear phagocytes: kinetics of and requirements for induction of lymphocyte function-associated (LFA)-1 antigen in vitro. (1985) (54)
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. (2007) (54)
Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event. (1998) (53)
Development, standardization and refinement of procedures for evaluating effects of endocrine active compounds on development and sexual differentiation of Xenopus laevis (2008) (53)
Association of Intercellular Adhesion Moleculeq (ICAM-1) with Actin-containing Cytoskeleton and -actinin (1992) (53)
Molecular basis for complement recognition by integrin αXβ2 (2012) (53)
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. (2008) (52)
Regulation of outside-in signaling and affinity by the β2 I domain of integrin αLβ2 (2006) (51)
Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway. (1988) (51)
The Relative Influence of Metal Ion Binding Sites in the I-like Domain and the Interface with the Hybrid Domain on Rolling and Firm Adhesion by Integrin α4β7* (2004) (51)
Transmission of allostery through the lectin domain in selectin-mediated cell adhesion (2009) (51)
Susceptibility of cytotoxic T lymphocyte (CTL) clones to inhibition by anti-T3 and anti-T4 (but not anti-LFA-1) monoclonal antibodies varies with the "avidity" of CTL-target interaction. (1985) (51)
The Binding Sites for Competitive Antagonistic, Allosteric Antagonistic, and Agonistic Antibodies to the I Domain of Integrin LFA-11 (2004) (50)
Cardiac graft intercellular adhesion molecule-1 (ICAM-1) and interleukin-1 expression mediate primary isograft failure and induction of ICAM-1 in organs remote from the site of transplantation. (1998) (50)
Activation-induced Conformational Changes in the I Domain Region of Lymphocyte Function-associated Antigen 1* (2002) (50)
Detergent solubilization, purification, and separation of specificities of HLA antigens from a cultured human lymphoblastoid line, RPMI 4265. (1977) (49)
The LFA-1, Mac-1 glycoprotein family and its deficiency in an inherited disease. (1985) (49)
The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface : Integrin a IIb b 3 (2009) (49)
Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13 (2015) (48)
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia (2016) (48)
Cell adhesion. Sticky sugars for selectins. (1991) (48)
Therapeutic antagonists and the conformational regulation of the beta2 integrins. (2004) (48)
Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction. (2001) (47)
Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. (2011) (47)
Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications (2012) (47)
Binding between the Integrin αXβ2 (CD11c/CD18) and Heparin* (2007) (47)
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration. (2003) (46)
Molecular Basis for Interaction between Icap1α PTB Domain and β1 Integrin* (2002) (46)
Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. (2015) (45)
Intercellular adhesion molecules (ICAM)‐1 ICAM‐2 and ICAM‐3 function as counter‐receptors for lymphocyte function‐associated molecule 1 in human immunodeficiency virus‐mediated syncytia formation (1994) (45)
Intercellular adhesion molecule‐1 (ICAM‐1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line (1988) (45)
Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation. (1998) (44)
Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy (2018) (44)
The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. (2019) (44)
Monoclonal antibodies and cell surface antigens. (1979) (44)
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. (2005) (43)
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation* (2009) (43)
The drive to ban the NOEC/LOEC in favor of ECx is misguided and misinformed (2013) (41)
The RGD finger of Del‐1 is a unique structural feature critical for integrin binding (2012) (41)
Monoclonal antibodies against rat glomerular antigens: production and specificity. (1983) (41)
Role of syngeneic Ia+ accessory cells in the generation of allospecific CTL responses. (1982) (40)
Statistical analysis of histopathological endpoints (2014) (40)
Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization (2007) (40)
CDw50 and ICAM‐3: Two names for the same molecule (1993) (39)
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. (2005) (39)
Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds. (1985) (39)
Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins. (1987) (39)
Heterogenous glycosylation of ICAM‐3 and lack of interaction with Mac‐1 and p150,95 (1995) (39)
Complement receptor type three-dependent degradation of opsonized erythrocytes by mouse macrophages. (1985) (38)
Modulation of Integrin Activation by an Entropic Spring in the β-Knee* (2010) (38)
Energy landscape differences among integrins establish the framework for understanding activation (2018) (38)
Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. (1999) (38)
Ambiguity of the thymidine index. (1976) (37)
The Top of the Inserted-like Domain of the Integrin Lymphocyte Function-associated Antigen-1 β Subunit Contacts the α Subunit β-Propeller Domain near β-Sheet 3* (2000) (37)
The connection between metal ion affinity and ligand affinity in integrin I domains. (2007) (36)
The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. (1986) (36)
Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. (2006) (36)
Stable hamster-mouse hybridomas producing IgG and IgM hamster monoclonal antibodies of defined specificity. (1983) (35)
Expression of glycophosphatidylinositol‐anchored and‐non‐anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells (1995) (35)
Biosynthesis and glycosylation of p150,95 and related leukocyte adhesion proteins. (1987) (35)
ADHESION OF T-LYMPHOBLASTS TO EPIDERMAL-KERATINOCYTES IS REGULATED BY INTERFERON-GAMMA AND MEDIATED BY LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN-1 (LFA-1) AND INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) (1988) (35)
Biochemical models of interferon-gamma-mediated macrophage activation: independent regulation of lymphocyte function associated antigen (LFA)-1 and I-A antigen on murine peritoneal macrophages. (1986) (35)
THE LYMPHOCYTE-T GLYCOPROTEIN CD2 (LFA-2/T11/E-ROSETTE RECEPTOR) BINDS THE CELL-SURFACE LIGAND LFA-3 (1987) (34)
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration (2008) (34)
Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening. (2010) (34)
Predicted and experimental structures of integrins and β-propellers (2002) (34)
Use of a monoclonal antibody specifically non-reactive with T cells to delineate lymphocyte subpopulations. (1981) (34)
The Immunoglobulin‐Like Structure of Human Histocompatibility Antigens (1974) (34)
Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor. (1987) (34)
Structure and regulation of the leukocyte adhesion receptor LFA-1 and its counterreceptors, ICAM-1 and ICAM-2. (1989) (34)
Bioaccumulation of decamethylpentacyclosiloxane (D5): A review (2015) (33)
Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases (2015) (33)
High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. (1995) (33)
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops (2016) (33)
Structures of the Toxoplasma gliding motility adhesin (2014) (33)
Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells. (1991) (32)
Distinct restriction of complement- and cell-mediated lysis. (1989) (32)
Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. (2005) (31)
Soluble intercellular adhesion molecule 1-immunoglobulin G1 immunoadhesin mediates phagocytosis of malaria-infected erythrocytes (1992) (31)
Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3 (1991) (31)
A New Interpretation of Avian and Mammalian Reproduction Toxicity Test Data in Ecological Risk Assessment (2005) (31)
A Small Molecule Agonist of an Integrin, αLβ2* (2006) (31)
Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2 (2017) (31)
A single monoclonal anti-Ia antibody inhibits antigen-specific T cell proliferation controlled by distinct Ir genes mapping in different H-2 I subregions. (1982) (31)
Purification and characterization of the lymphocyte function-associated-2 (LFA-2) molecule. (1986) (31)
Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia (1996) (30)
Differential regulation of (31 and 082 integrin avidity by chemoattractants in eosinophils (1996) (30)
Role of a , & lntegrin Avidity in Transendothelial Chemotaxis of Mononuclear Cells ‘ (2001) (29)
Neutrophil Accumulation on Activated , Surfaceadherent Surfaceadherent Surfaceadherent Platelets in Flow Is Mediated by Interaction of Mac1 Mac1 Mac1 with Fibrinogen Bound to a IIb b 3 and Stimulated by Plateletactivating Plateletactivating Plateletactivating Factor (1997) (29)
Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. (2006) (29)
Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1. (1992) (29)
Prodomain–growth factor swapping in the structure of pro-TGF-β1 (2017) (29)
Antigens associated with the activation of murine mononuclear phagocytes in vivo: differential expression of lymphocyte function-associated antigen in the several stages of development. (1985) (29)
The Domain Structure of ICAM-1 and the Kinetics of Binding to Rhinovirus (1998) (29)
LFA-1 but not Lyt-2 is associated with killing activity of cytotoxic T lymphocyte hybridomas (1982) (29)
Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. (2002) (28)
A Novel Ca2+ Binding β Hairpin Loop Better Resembles Integrin Sequence Motifs Than the EF Hand (2000) (28)
Analysis of macrophage differentiation and function with monoclonal antibodies. (1984) (28)
Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation (2018) (28)
Characterization of two new CD18 alleles causing severe leukocyte adhesion deficiency (1993) (28)
Atypical interactions of integrin αVβ8 with pro-TGF-β1 (2017) (28)
Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens. (1977) (27)
Cation-π interaction regulates ligand-binding affinity and signaling of integrin α4β7 (2010) (27)
ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. (1995) (27)
Faculty Opinions recommendation of Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. (2003) (27)
Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain* (2013) (26)
Cloning and chromosomal localization of a novel gene-encoding a human β2-integrin α subunit (1996) (26)
Assessment of an approach to estimating aquatic bioconcentration factors using reduced sampling (2008) (26)
Fusion surface structure, function, and dynamics of gamete fusogen HAP2 (2018) (26)
Effect of lengthening lymphocyte function-associated antigen 3 on adhesion to CD2. (1992) (26)
Chemical and immunological characterization of HL-A linked B-lymphocyte alloantigens. (1977) (26)
The Human Leukocyte Adhesion Glycoprotein Mac-1 ( Complement Receptor Type 3 , CDllb ) a ! Subunit (25)
Structure and allosteric regulation of the alpha X beta 2 integrin I domain. (2003) (25)
The function of LFA-1 in cell-mediated killing and adhesion: studies on heritable LFA-1, Mac-1 deficiency and on lymphoid cell self-aggregation. (1985) (25)
Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model. (2001) (25)
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions. (2004) (24)
Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. Evidence for structural homology of the sheep and human ligands of CD2. (1987) (24)
Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines. (1998) (24)
Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and Signaling* (2010) (23)
A birth certificate for CD2 (1991) (23)
Effects of 17 β‐estradiol exposure on Xenopus laevis gonadal histopathology (2010) (23)
Case Study Part 1: How to Calculate Appropriate Deterministic Long-Term Toxicity to Exposure Ratios (TERs) for Birds and Mammals (2005) (23)
A Schiff Base with Mildly Oxidized Carbohydrate Ligands Stabilizes L-selectin and not P-selectin or E-selectin Rolling Adhesions in Shear Flow (*) (1996) (23)
The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule. (1985) (23)
Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3. (2015) (23)
MTBE ambient water quality criteria development: a public/private partnership. (2002) (22)
An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2. (2013) (22)
Comparison of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) as test species in the Fish Sexual Development Test (FSDT). (2012) (22)
Statistical Analysis of Ecotoxicity Studies (2018) (22)
Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses (1998) (22)
Monoclonal xenogeneic antibodies to mouse leukocyte antigens: identification of macrophage-specific and other differentiation antigens. (1978) (22)
Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1 (2009) (22)
Blocking of CTL-mediated killing by monoclonal antibodies to LFA-1 and LYT-2,3. I. Increased susceptibility to blocking after papain treatment of target cells. (1983) (21)
β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece* (2015) (21)
Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones. (1986) (21)
Characterization of a monoclonal rat anti-mouse interleukin 2 (IL-2) receptor antibody and its use in the biochemical characterization of the murine IL-2 receptor. (1985) (20)
Case Study Part 2: Probabilistic Modelling of Long-term Effects of Pesticides on Individual Breeding Success in Birds and Mammals (2005) (20)
General structural features that regulate integrin affinity revealed by atypical αVβ8 (2019) (20)
Leukocyte complement receptors and adhesion proteins in the inflammatory response: insights from an experiment of nature. (1986) (20)
Functional studies of truncated soluble intercellular adhesion molecule 1 expressed in Escherichia coli (1993) (20)
Metal ion and ligand binding of integrin alpha 5 beta 1. (2014) (20)
Structure of HL-A A and B antigens isolated from cultured human lymphocytes. (1977) (19)
Can we reduce the number of fish in the OECD acute toxicity test? (2011) (19)
Identification and characterization of a human monoclonal antagonistic antibody AL‐57 that preferentially binds the high‐affinity form of lymphocyte function‐associated antigen‐1 (2006) (19)
The molecular basis for cytolytic T lymphocyte function: analysis with blocking monoclonal antibodies. (1982) (19)
A tiered assessment strategy for more effective evaluation of bioaccumulation of chemicals in fish. (2016) (19)
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains. (1998) (19)
Polymorphism of lymphocyte function-associated antigen-1 demonstrated by a lupus patient's alloantiserum. (1987) (18)
Human leukocyte adhesion deficiency: molecular basis for a defective immune response to infections of the skin. (1989) (18)
Structural specializations of $\alpha_4 \beta_7$, an integrin that mediates rolling adhesion (2012) (18)
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit. (1997) (18)
Signals on endothelium for lymphocyte recirculation and leukocyte emigration: the area code paradigm. (1993) (18)
The Novel S527F Mutation in the Integrin β3 Chain Induces a High Affinity αIIbβ3 Receptor by Hindering Adoption of the Bent Conformation* (2009) (18)
Update of CD antigens, 1996. (1997) (18)
Does Atrazine Affect Larval Development and Sexual Differentiation of South African Clawed Frogs? (2009) (18)
Human Cytolytic T-Lymphocyte Clones and Their Function-Associated Cell Surface Molecules (1985) (17)
The Structure of Products of the Major Histocompatibility Complex in Man (1976) (17)
The C-Terminal αI Domain Linker as a Critical Structural Element in the Conformational Activation of αI Integrins* (2011) (17)
Electrostatic Steering Enables Flow-Activated Von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging. (2019) (17)
UNIT 10.16 Immunoprecipitation (2001) (16)
A small molecule agonist of an integrin, alphaLbeta2. (2006) (16)
Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1 (2018) (16)
Cloning and expression of the chicken CD18 cDNA (1994) (16)
Monoclonal antibodies and cell surface antigens. (1979) (16)
High Affinity Ligand Binding by Integrins Does Not Involve Head Separation* (2003) (16)
Predicted and experimental structures of integrins and beta-propellers. (2002) (15)
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP (2020) (15)
Epstein-Barr VirusLatent Infection MembraneProtein Alters the HumanB-Lymphocyte Phenotype: Deletion oftheAminoTerminus Abolishes Activity (1988) (15)
César Milstein, the father of modern immunology (2002) (14)
Antibodies Specific for the Mac-1, LFA-1, p150,95 Glycoproteins or Their Family, or for Other Granulocyte Proteins, in the 2nd International Workshop on Human Leukocyte Differentiation Antigens (1986) (14)
All monocyte antigens are not expressed on renal endothelium. (2008) (13)
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen (2004) (13)
High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate (2018) (13)
Mutational analysis of MAdCAM-1/α4β7 interactions reveals significant binding determinants in both the first and second immunoglobulin domains (1999) (13)
Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit. (1997) (13)
UNIT 8.3 Immunoprecipitation (2001) (13)
A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. (1986) (13)
Engineering of Single Ig Superfamily Domain of Intercellular Adhesion Molecule 1 (ICAM-1) for Native Fold and Function* (2010) (13)
A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry. (2018) (12)
Human lymphocyte function associated antigens (1984) (12)
Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus. (2017) (12)
An avian reproduction study historical control database: A tool for data interpretation (2018) (12)
Interactions of Human ~/~3 and ~//8 T Lymphocyte Subsets in Shear Flow with E-Selectin and P-Selectin (1996) (12)
An Extracellular b-Propeller Module Predicted in Lipoprotein and Scavenger Receptors, Tyrosine Kinases, Epidermal Growth Factor Precursor, and Extracellular Matrix Components (1998) (12)
Immunological Identity of the Small Subunit of HLA Antigens and $ 2-Microglobulin and Its Turnover on the Cell Membrane ( immunoglobulins / lymphocytes / histocompatibility ) (12)
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). (2001) (11)
Leucocyte adhesion to cells. (1990) (11)
Intercellular Adhesion Molecule‐1 (ICAM‐1) Monoclonal Antibody Inhibits Cytotoxic T Lymphocyte Recognition (1988) (11)
Leukocyte Adhesion Molecules (2011) (11)
[31] Preparation and use of monoclonal antimacrophage antibodies (1984) (10)
Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines (2019) (10)
UNIT 9.8 Immunoprecipitation (2001) (10)
A general chemical principle for creating closure-stabilizing integrin inhibitors (2022) (10)
Folding of the b-propeller domain of the integrin a L subunit is independent of the I domain and dependent on the b 2 subunit (1997) (10)
Functional and Structural Interrelationships among the Mac-1, LFA-1 Family of Leukocyte Adhesion Glycoproteins, and their Deficiency in a Novel Heritable Disease (1985) (10)
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b (2021) (10)
Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia. (1998) (10)
Selective Targeting of High‐Affinity LFA‐1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model (2017) (9)
Storage of solar energy by inorganic oxide/hydroxides (1976) (9)
Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. (1996) (9)
Kinetics of Receptor and Virus Interaction and Receptor-Induced Virus Disruption: Methods for Study with Surface Plasmon Resonance (1994) (9)
Structural and Functional Studies with Antibodies to the Integrin b 2 Subunit (2000) (9)
Complement receptor 3 forms a compact high affinity complex with iC3b (2020) (8)
Preparation and use of monoclonal antimacrophage antibodies. (1984) (8)
MONOCLONAL ANTIBODIES AS TOOLS FOR THE STUDY OF MONONUCLEAR PHAGOCYTES (1981) (8)
Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. (2017) (8)
Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state (2021) (8)
Automated determination of critical oxygen concentration for routinely active fish (1988) (8)
Specific high affinity interaction of Helicobacter pylori CagL with integrin αVβ6 promotes type IV secretion of CagA into human cells (2019) (8)
A high affinity human antibody antagonist of P-selectin mediated rolling. (2006) (8)
Neutrophil Rolling , Arrest , and Transmigration Across Activated , Surface-Adherent Platelets Via Sequential Action of P-Selectin and the &-Integrin CDllb / CDl 8 (2002) (8)
Metabolism of 14C-octamethylcyclotetrasiloxane ([14C]D4) or 14C-decamethylcyclopentasiloxane ([14C]D5) orally gavaged in rainbow trout (Oncorhynchus mykiss). (2017) (8)
Production of Syrian and Armenian hamster monoclonal antibodies of defined specificity. (1986) (8)
Measurement of selectin tether bond lifetimes. (2002) (8)
A Deterministic Model of the Response of Threadfin Shad to Aquatic Macrophyte Control (1990) (7)
Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains. (1999) (7)
Ideas crystallized on immunoglobulin superfamily-integrin interactions. (1995) (7)
Quantitation of hybridoma immunoglobulins and selection of light-chain loss variants. (1983) (7)
Common Interests of the IGS and the IVS (2000) (7)
The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3. (2000) (7)
Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1. (1995) (7)
Spontaneous Rosetting of T Lymphocytes to Reed‐Sternberg Cells Is Mediated by the CD2/LFA‐3 and LFA‐1/ICAM‐1 Pathways of Antigen‐Independent Adhesion (1988) (6)
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse (2018) (6)
Domain 1 of Mucosal Addressin Cell Adhesion Molecule Has an I1-set Fold and a Flexible Integrin-binding Loop* (2013) (6)
Structure of integrin a 5 b 1 in complex with ® bronectin (6)
Immunoprecipitation (2001) (5)
More for less: Analysis of the performance of avian acute oral guideline OECD 223 from empirical data (2017) (5)
[Successful prevention of rhinovirus infections with chimeric ICAM-1 immunoglobulin in vitro]. (1993) (5)
CD11c regulates hematopoietic stem and progenitor cells under stress. (2020) (5)
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2 (2021) (5)
NATWRAL KILLER CELL AND GRANULOCYTE Fcr DIFFER IN MEMBRANE ANCHOR AND SIGNAL RECEPTOR I11 (CD16) TRANSDUCTION (1989) (5)
The next human leukocyte differentiation antigen workshop (1992) (5)
Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange (2022) (5)
Update: new CD antigens, 1996. (1997) (5)
Quantitation of light chain synthesis in myeloma x spleen cell hybrids and identification of myeloma chain loss variants using radioimmunoassay. (1980) (5)
Structural and Functional Studies with Antibodies to the Integrin β2 Subunit (2000) (4)
A Small Molecule Agonist of an Integrin, (2006) (4)
Disulfide exchange in multimerization of von Willebrand factor and gel-forming mucins (2021) (4)
Detergent-soluble products of the HLA region. (1977) (4)
Area Code Molecules of Lymphocytes (1990) (4)
beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece. (2016) (4)
Immunoprecipitation (1999) (4)
Disulfide Exchange in von Willebrand factor Dimerization in the Golgi. (2020) (4)
ASSOCIATED LFA-I, CD2, and LFA-3 MOLECULES: Cell Adhesion Receptors of the Immune System (1987) (4)
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. (2011) (4)
ANALYSIS OF THE LFA-1 AND CD2/LFA-3 PATHWAYS OF ANTIGEN-INDEPENDENT ADHESION USED BY HUMAN CYTOTOXIC T-CELL CLONES (1987) (3)
Regulation by metal ions and the ADMIDAS of integrin α5β1 conformational states and intrinsic affinities. (2022) (3)
The immunoglobulin-like structure of human histocompatibility antigens. (1976) (3)
PURIFIED LFA-3 ANTIGEN ACTIVATES HUMAN THYMOCYTES VIA THE CD2 PATHWAY (1988) (3)
The LFA-1, Mac-1 leucocyte adhesion glycoprotein family and its deficiency in a heritable human disease. (1985) (3)
The leukocyte lntegrin pl 50 , 95 ( CD 11 c / CD 18 ) as a Receptor for iC 3 b Activation by a Heterologous p Subunit and localization of a Ligand Recognition Site to the I Domain ’ (3)
Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair (2001) (3)
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. (2013) (3)
ISOLATION AND STRUCTURE OF PRODUCTS OF THE HUMAN HISTOCOMPATIBILITY GENE COMPLEX (1976) (3)
Adhesion Receptors Regulate Antigen-Specific Interactions, Localization, and Differentiation in the Immune System (1989) (3)
Cell adhesion. A birth certificate for CD2. (1991) (2)
THE CRYSTAL STRUCTURE OF ICAM-2 (1997) (2)
Fc receptors and the action of antibodies Edited by H. Metzger. Washington, DC: American Society for Microbiology. (1990). 368 pp. $65.00 (1991) (2)
STUDIES OF THE STRUCTURE OF THE HUMAN Ia-LIKE ANTIGEN (1978) (2)
Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation (2017) (2)
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide (2008) (2)
Inherited LFA-1, Mac-1 deficiency and its molecular biology (1985) (2)
Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1 (2012) (2)
Reflections on Integrins-Past, Present, and Future: The Albert Lasker Basic Medical Research Award. (2022) (2)
Structural Plasticity in IgSF Domain 4 of ICAM-1 Mediates Cell Surface Dimerization (2007) (2)
The value of avian gross pathology in identifying endocrine disrupting properties. (2020) (2)
Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association. (2021) (2)
Testing of an Energy Efficient Environmental Control System for Patrol-Type Aircraft (1992) (2)
STUDIES OF A NEW GENETIC DISEASE CHARACTERIZED BY A DEFICIENT PMN LEUKOCYTE SURFACE GLYCOPROTEIN(S) (1984) (2)
A Cluster of Antibodies (RR1/1, LB-2 and 84H10) That Inhibit LFA 1-Dependent Lymphoid and Myeloid Cell Adhesion Bind Intercellular Adhesion Molecule-1 (ICAM-1) (1989) (2)
The next cluster of differentiation (CD) workshop (1991) (2)
How three VWD mutations destabilize the A 2 domain 1 Mechanisms by which von Willebrand Disease Mutations Destabilize the A 2 Domain (2013) (2)
Automatic monitoring of short duration snowmelt events in a nova scotia headwater stream (1989) (1)
A SINGLE MONOCLONAL ANTI-la ANTIBODY INHIBITS ANTIGEN-SPECIFIC T CELL SUBREGIONS' PROLIFERATION CONTROLLED BY DISTINCT h GENES MAPPING IN DIFFERENT H-2 I (1982) (1)
Single-molecule characterization of subtype-specific β1 integrin mechanics (2022) (1)
Amino Acid Residues in the IIb Subunit That Are Critical for Ligand Binding to Integrin (2001) (1)
Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging (2022) (1)
Immunoprecipitation (1999) (1)
A partial genomic DNA clone for the a subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1 ( oligonucleotide probes / macrophage / y interferon-stimulated premyelocyte maturatlon / mRNA / celi adhesion molecule LFA-1 ) (1)
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker (2022) (1)
Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. (1983) (1)
Intercellular adhesion molecule 2 and their binding ligands. (1990) (1)
RETROSPECTIVE: César Milstein (1927-2002) (2002) (1)
Loss of LRRC33-dependent TGFβ1 activation enhances anti-tumor immunity and checkpoint blockade therapy. (2022) (1)
Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state (2022) (1)
Coordinate-Enhanced Expression of Three Adhesion Molecules (LFA-3, CD2, and LFA-1) and Three Other Molecules (4B4, UCHL1, and Pgp-1) Defines a Human T Cell Subset Containing Memory Cells and Characterized by Enhanced γ Interferon Production (1989) (1)
Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family. (2022) (1)
PURIFICATION AND CD2 BINDING FUNCTION OF LFA-3 (1987) (1)
STABLE HAMSTER-MOUSE MONOCLONAL HYBRIDOMAS PRODUCING IgG AND IgM HAMSTER ANTIBODIES OF DEFINED SPECIFICITY' (1983) (1)
Validation of the fish sexual development test as an OECD guideline to detect endocrine disrupters: Phase 1 results (2008) (1)
Crystal structure of VWF A2 domain (2009) (1)
Immunoprecipitation (2006) (1)
Congenital X‐linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6 (2021) (1)
Structural, Functional, and Dynamic Characterization of the Binding Site of RUC-1, a Novel αIIb-Specific Inhibitor of Integrin αIIbβ3. (2009) (1)
The fish sexual development test: an OECD test guideline proposal with possible relevance for environmental risk assessment. Results from the validation programme. (2010) (1)
Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-i in human neutrophils during stimulation with inflammatory mediators Niels BorregaardLars KjeldsenHenrik Sengel#{243}vMichael S. Diamond,' (1994) (1)
Partial Purification of Detergent-Soluble HLA Antigen and Its Cleavage by Papain ( 82-microglobulin / Brij 9 / histocompatibility ) (1)
Risk Assessment and Regulation of D 5 in Canada BIOACCUMULATION OF DECAMETHYLPENTACYCLOSILOXANE ( D 5 ) : A REVIEW (2015) (1)
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration (2017) (1)
Postdoc Colloquium 2 : Implications for Familial Hypercholesterolemia from Structure of the LDL Receptor YWTD-EGF Domain Pair (2002) (1)
Author response: Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP (2020) (0)
Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form (2012) (0)
Resource Measuring Integrin Confor mational Change on the Cell Surface with Super-Resolution Microscopy Graphical (2018) (0)
A Highly Specific Gold Nanoprobe for Live-Cell Single-Molecule Imaging in Confined Environments: Intracellular Tracking and Long-Term Single Integrin Tracking in Adhesion Sites (2014) (0)
Integrin alpha V beta 6 in complex with pro-TGF-beta (2017) (0)
Retrofit of U.S. Navy Aircraft Vapor Cycle Systems to Accommodate Non-CFC-Based Refrigerants (1995) (0)
THE LYMPHOCYTE ASSOCIATED LFA-1 , LFA-3 MOLECULES " Receptors FUNCTION-CD 2 , and Cell Adhesion of the Immune System (2002) (0)
THEORETICAL MODEL OF HUMAN NIDOGEN YWTD BETA-PROPELLER DOMAIN (1998) (0)
Deficiency of the Adhesive Protein Complex Lymphocyte Function Antigen 1 , Complement Receptor Type 3 , Glycoprotein p 150 , 95 in a Girl with Recurrent Bacterial Infections (2013) (0)
crystal structure of a4b7 headpiece complexed with Fab ACT-1 (2012) (0)
Crystal structure of alpha V beta 6 with peptide (2014) (0)
Crystal structure of human von Willebrand factor CTCK domain (2014) (0)
Human Umbilical Vein Endothelial Cell ( HUVEC ) , Epithelial , and Dermal Fibroblast Assays (2002) (0)
Alpha-subenhet of the Mac-1 leukocytadehesionsreceptor. (1989) (0)
Author response: Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state (2021) (0)
Isolation of Lymphocytes from Blood and Human Tonsil (1997) (0)
Crystal structure of a loop deleted mutant of human MAdCAM-1 D1D2 complexed with Fab 10G3 (2013) (0)
Crystal structure of magnesium-loaded Plasmodium vivax TRAP protein (2012) (0)
DEPENDENCE OF CD2 ON CD3/TI FOR TRANSMEMBRANE SIGNALING (1988) (0)
Crystal structure of an atypical integrin (2019) (0)
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha (2014) (0)
Crystal Structure of the Integrin αIIBβ3 Headpiece at 2.7–3.1 Å: Structure, Mechanisms of Activation and Ligand Binding, Inhibition by Eptifibatide, Tirofiban, and mAb 10E5, and Structure of the HPA-1 Alloantigen Epitope. (2004) (0)
Low affinity integrin states have faster binding kinetics than the high affinity state (2021) (0)
Crystal structure of human MAdCAM-1 D1D2 complexed with Fab PF-547659 (2013) (0)
Von Willebrand Factor, a Force-Selective Platelet Binder and Factor VIII Carrier (2018) (0)
Activator Protein-2 B and k Transcriptionally Regulated by NF--3-Oxododecanoyl Homoserine Lactone Is N Autoinducer Pseudomonas and Epithelial Cells Activated by the IL-8 Production in Human Lung Fibroblasts (2001) (0)
The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling (2010) (0)
Relationships between the composition of waters of East and Central Texas lakes and the ion exchange characteristics of their watersheds and muds (1983) (0)
Lymphocyte Delivery to HighEndothelial Venules (2016) (0)
Lateral Migration Chemotaxis of Monocytes by Facilitating VCAM-1 Supports Transendothelial Interaction of Very Late Antigen-4 with (1998) (0)
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha (2014) (0)
Shear flow has minimal role in unfolding of free von Willebrand factor (2022) (0)
THE CRYSTAL STRUCTURE OF MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) (1999) (0)
Structure of Toxoplasma gondii proMIC2 (2014) (0)
Crystal structure of Plasmodium falciparum TRAP, P4212 form (2012) (0)
Immunological Identity of the Small Subu t2-Microglobulin and Its Turnover on the (immunoglobulins/lymphocytes/histocompatibility) (2016) (0)
Subtype-specific single-molecule mechanics for integrin activation, mechanotransduction and cytoskeleton remodeling (2022) (0)
Re-refinement of Integrin AlphaIIbBeta3 Headpiece (2008) (0)
Patents and literature (1985) (0)
Theoretical Model of the beta-Propeller Domain of Integrin alphaIIb (2001) (0)
Inventory of Ponds in the Brazos and Colorado River (Texas) Drainages, from NASA Color Infrared Photography. (1986) (0)
Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV (2008) (0)
LEUKOCYTE INTEGRIN P 150 , 95 ( CDllc / CD 18 ) FUNCTIONS AS AN ADHESION ENDOTHELIUM ' MOLECULE BINDING TO A COUNTER-RECEPTOR ON STIMULATED (2001) (0)
ANTIGEN-INDEPENDENT CONJUGATE FORMATION - LIGAND ANALYSIS BY PROTEASE TREATMENT AND ROLE OF CARBOHYDRATES (1987) (0)
Partial Purification ofDetergent-Soluble HL-AAntigen andIts Cleavage byPapain (1974) (0)
Micro-mechanics of T lymphocyte-erythrocyte rosettes (1991) (0)
Crystal structure of circumsporozoite protein aTSR domain, R32 native form (2012) (0)
ArticleStructural Basis for Dimerization of ICAM-1 on the Cell (2004) (0)
THEORETICAL MODEL OF YWTD DOMAIN 7 OF THE CHICKEN LRP1 (LDLR-RELATED) SCAVENGER RECEPTOR (1999) (0)
Principles governing the rapid organization of adhesion molecules in cell-cell contact areas. (1997) (0)
1025 CONCANAVALIN A BINDING PROTEINS OF THE HUMAN POLYMORPHONUCLEAR LEUKOCYTE PLASMA MEMBRANE (1985) (0)
Lymphocyte Trafficking Molecule-1 ( ICAM-1 ) and ICAM-2 in Endothelial Intercellular Adhesion Overlapping and Selective Roles of Alf (2003) (0)
Integrin alphaIIB beta3 headpiece and RGD peptide complex (2013) (0)
Single-Molecule Activation by Flow: Force-Induced Conformational Transitions Regulate the Ligand Binding Affinity of a Large, Polymeric Mechanosensor Protein (2016) (0)
Flow-induced elongation of von Willebrand factor precedes tension-dependent activation (2017) (0)
Theoretical Model of the Integrin Beta2 I-like Domain (2001) (0)
X-Ray Diffraction data from integrin alphaVbeta6 head/pro-TGF-beta1 complex, source of 5FFO structure (2016) (0)
The Novel S527F Mutation in the Integrin 3 Chain Induces a High Affinity IIb3 Receptor by Hindering Adoption of the (2009) (0)
Structure‐function of MAdCAM‐1 revealed by single‐molecule force spectroscopy (2006) (0)
CHARACTERIZATION OF THE MOLECULAR BASIS FOR PMN DYSFUNCTION & RECURRENT INFECTION IN THE GP-138 DEFICIENCY SYNDROME (1984) (0)
Very late antigen 4 dependent adhesion of lymphocytic cell lines to cultured human endothelium (1991) (0)
Alpha receptor subunit LFA-1 adhesion to leukocyte. (1989) (0)
Expression of Activated LFA-1 in Human Renal Allografts With Rejection.: Abstract# C1527 (2014) (0)
leukocyte integrin , X 2 (2013) (0)
Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker (2022) (0)
Crystal structure of high affinity alphaL I domain in the absence of ligand or metal (2003) (0)
Unfolding, refolding and proteolysis of the von Willebrand Factor A2 domain under tensile force (2009) (0)
Single-Molecule Imaging of Von Willebrand Factor Activation by Flow (2014) (0)
BIOLOGY OF LYMPHOCYTE ADHESION RECEPTORS (1990) (0)
crystal structure of quinine-dependent Fab 314.1 (2015) (0)
Cationic charge and polyspecificity of an integrin domain regulates infectivity of malaria parasites (2018) (0)
Crystal structure of monomeric von Willebrand Factor D`D3 assembly (2019) (0)
Activation of A1 Domain Adhesiveness in von Willebrand Factor by Elongational Force (2012) (0)
Conformational activation of 2 integrins, their I domains, and regulation by small molecule antagonists (2002) (0)
Immunology. Retrospective: César Milstein (1927-2002). (2002) (0)
The crystal structure of ICAM-2, its comparison to other integrin-binding proteins (1996) (0)
Ambiguity of the Thymidine Index1 (2006) (0)
Crystal structure of Plasmodium vivax TRAP protein (2012) (0)
The Ability of NK Cell and Granulocyte Forms of CD 16 to Trigger Cytolytic Function (1990) (0)
Memory/Effector T Cells Invadosome-like Protrusions Formed by Antigen Recognition Is Facilitated by (2012) (0)
Atypical interactions of integrin α ß with pro-TGF-ß1. (2017) (0)
Vedhaeftningsmolekyler and intercellular ligands which can be bonded thereto (1990) (0)
Alpha-subunit of LFA-1 leukocyte adhesion receptor. (1989) (0)
Theoretical Structure of Icap1-alpha Bound to Integrin beta1 Cytoplasmic Domain (2002) (0)
Re-refinement of alpha V beta 3 structure (2012) (0)
Structure of headpiece of integrin aIIBb3 in open conformation (2009) (0)
Letter to the Editor (1990) (0)
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS (2012) (0)
crystal structure of quinine-dependent Fab 314.3 (2015) (0)
Structure of integrin alphaX beta2 (2010) (0)
Crystal structure of a loop deleted mutant of Human MAdCAM-1 D1D2 (2013) (0)
Crystal Structure of pro-TGF beta 1 (2011) (0)
Crystal structure of native human MAdCAM-1 D1D2 domain (2013) (0)
Integrin alphaIIbbeta3 in complex with Ro-435054 (2015) (0)
Stretching and Activation of Single Protein Molecules by Flow Reveals the Mechanism of von Willebrand Factor Adhesion (2018) (0)
crystal structure of quinine-dependent Fab 314.3 with quinine (2015) (0)
Radiolabeling of Lymphoblastoid Cell Lines and Papain Digestion.--RPMI (0)
Structural and Functional Studies with Antibodies to the Integrin b2 Subunit (2000) (0)
MOLECULAR PATHWAYS OF ADHESION BY HUMAN LYMPHOCYTES-T IN ERYTHROCYTE ROSETTING AND CONJUGATE FORMATION (1987) (0)
Crystal structure of human pro-TGF-beta1 (2017) (0)
Crystal structure of circumsporozoite protein aTSR domain, P43212 form (2012) (0)
Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein (2018) (0)
Cell Fusion-Monoclonal Antibody Immunoadsorbent Cascades 3835 (2001) (0)
De novo Design of a Highly Specific Inhibitor of Integrin Αvβ6 for Pulmonary Fibrosis (2021) (0)
Integrin alphaIIbbeta3 in complex with AGDV peptide (2015) (0)
Structure-Guided Design of A Novel High Affinity Integrin αIIbβ3 Receptor Antagonist (RUC-2) That Displaces Mg 2+ From the β3 MIDAS, (2011) (0)
PLATELETS AND THROMBOPOIESIS Structural basis for quinine-dependent antibody binding to platelet integrin a IIb b 3 (2015) (0)
Soluble functional derivative of ICAM-1, recombinant DNA molecule and method for preparing said derivative, pharmaceutical composition containing such derivative and the use of the derivative to prepare such preparation, and ... (1990) (0)
Previous studies have shown that mAbs to the lymphocyte function-associated 1 (LFA-1)I molecule inhibit the effector-target adhesion step of CTL-mediated killing (5), and a wide variety of other adhesion-dependent leukocyte functions, including antigen-specific T-B cell cooperation, antigen-specific (2003) (0)
INTERACTION BETWEEN CD2 AND LFA-3 MEDIATES ROSETTING OF ACTIVATED HUMAN LYMPHOCYTES-T WITH HUMAN-E (1987) (0)
Adherence strength of T cells to planar membranes containing LFA-3 molecules (1991) (0)
Intercellulaera adhesionsmolekyler Science deras ligander. (1990) (0)
ROLE OF SYNGENEIC la' ACCESSORY CELLS IN THE CTL RESPONSES GENERATION OF ALLOSPECIFIC (1982) (0)
Crystal structure of A4b7 headpiece complexed with Fab Natalizumab (2013) (0)
Modified, stabilized in the desired conformation polypeptides and methods for their preparation (2001) (0)
X-Ray Diffraction data from integrin alphaVbeta6 head, source of 5FFG structure (2016) (0)
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation (2014) (0)
Selective Targeting of Activated LFA-1 Using a Novel Antibody, AL-579, in Nonhuman Primate Kidney Transplantation.: Abstract# 1358 (2014) (0)
Binding site ICAM-1 to Mac-1. (1991) (0)
Faculty Opinions recommendation of Novel mutant human fibronectin FIII9-10 domain pair with increased conformational stability and biological activity. (2003) (0)
Integrin EGF-like module 3 from the beta-2 subunit (2002) (0)
Phenotyping of macrophages, dentritic cells, and NK cells (1985) (0)
Crystal structure of integrin alpha V beta 6 head (2017) (0)
THROMBOSIS AND HEMOSTASIS Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor (2014) (0)
The Crystal Structure of ICAM-1 D3-D5 fragment (2004) (0)
Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide (2019) (0)
Two-dimensional Kinetics Regulation of L2 -ICAM-1 Interaction by Conformational Changes of the (2005) (0)
Subsets in Shear F low with E-Select in and P-Select in By (2003) (0)
Modifying themechanical propertyandshear threshold of L-selectinadhesion independentlyof equilibriumproperties (1998) (0)
ROLE OF RECEPTOR MOBILITY IN CELL-ADHESION STRENGTHENING (1991) (0)
crystal structure of quinine-dependent Fab 314.1 with quinine (2015) (0)
MAC-1 binding position of ICAM-1 (1991) (0)
Anti-tail monoclonal antibodies change the conformation of ADAMTS13 into a hyperactive state (2014) (0)
Structures of Toxoplasma gondii MIC2 (2014) (0)
THEORETIC MODEL OF THE HUMAN LOW-DENSITY LIPOPROTEIN RECEPTOR YWTD BETA-PROPELLER DOMAIN (1999) (0)
Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation (2011) (0)
Pro-bone morphogenetic protein 9 (2015) (0)
crystal structure of ICAM-5 in complex with aL I domain (2008) (0)
Computational Prediction and Experimental Validation of a Novel Binding Site for Platelet Integrin AlphaIIb-Beta3 (2010) (0)
crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 (2012) (0)
Structural basis for distinctive recognition of ﬁ brinogen (cid:4) C peptide by the platelet integrin (cid:2) IIb (cid:3) 3 (2008) (0)
Cleaning of LFA-third (1988) (0)
Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact (2003) (0)
Wound Healing Decreased by IL-1 and TNF and in Dermal Expression of Stromal-Derived Factor-1 Is (2001) (0)
HUMAN MAC-1 BETA-PROPELLER, THEORETICAL MODEL (1998) (0)
its cleavage by ADAMTS13 A novel calcium-binding site of von Willebrand factor A2 domain regulates (2011) (0)
Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein (2002) (0)
Notes on Contributors (2005) (0)
headpiece with a glycan wedge increases (2016) (0)
non-latent pro-bone morphogenetic protein 9 (2015) (0)
The flexible tail of the hemostatic enzyme ADAMTS13 is able to shield the active site (2014) (0)
Crystal structure of Nidogen/Laminin Complex (2003) (0)
Immunoaffinity Chromatography (1996) (0)
Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family (2021) (0)
current as physiologic flow conditions . leukocyte tethering and rolling under Glycolipid ligands for selectins support (2001) (0)
A Small-Molecule Antagonist to Integrin LFA-1 Reveals a Crucial Inter-Domain Communication as a Novel Therapeutic Target. (2004) (0)
kiinnikemolekyylejä and their inter-cell binding ligand (1998) (0)
Common activation mechanism of beta 2 integrins (P5073) (2013) (0)
Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A (2005) (0)
Engagement of Leukocyte LFA-1 Intercellular Adhesion Molecule 1 Microvilli-Like Membrane Projections upon Endothelial Cells Proactively Form (2003) (0)
Structure of complete ectodomain of integrin aIIBb3 (2009) (0)
Integrin-Dependent Difference in Cell Adhesion and Force Exertion (2020) (0)
Crystal structure of alpha V beta 6 (2014) (0)
Crystal structure of alphaL I domain in complex with ICAM-1 (2003) (0)
Dendritic cell-expressed common cytokine receptor g-chain is essential for effective IL-15 transpresentation to CD4+T cells at the immunological synapse (2013) (0)
T-CELL ACTIVATION BY LFA-3 AND CD2 ANTIBODIES (1988) (0)
The method of ICAM-1 (intercellular kiinnikemolekyylin) a soluble, functional derivative thereof for the preparation of (1990) (0)
THE CRYSTAL STRUCTURE FOR THE N-TERMINAL TWO DOMAINS OF ICAM-1 (1998) (0)
Molecular analysis of human leukocyte adhesion deficiency (1988) (0)
On-Rate Switching under Force Increases the Binding of von Willebrand Factor A1 to GPIbα (2016) (0)
The T cell chemokine MCP-1 induces adhesion of T cells to fibronectin, but not to ICAM-1 or VCAM-1 (1995) (0)
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 (2008) (0)
Time-Lapse Video Microscopy Recording (2003) (0)
Crystal Structure of Del-1 EGF domains (2012) (0)
Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV (2008) (0)
ICAM-1 and LFA-1-Mediated Cell Aggregation Differential Requirements for LFA-1 Binding to (1998) (0)
RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion. (2004) (0)
Binding of actin by neutrophil (PMN) C3b receptor (CR1), iC3b receptor (CR3) and Fc receptor (FcR), but not by HLA class I or erythrocyte (E) CR1 (1986) (0)
Crystal structure of the alpha-X beta2 integrin I domain (2003) (0)
Method for the preparation of ICAM-2 and recombinant DNA molecule (1990) (0)
Structure of integrin alphaX beta2 ectodomain (2010) (0)
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the immunological synapse (P6286) (2013) (0)
Integrin allostery and bidirectional signal transmission across the plasma membrane (2007) (0)
RESEARCH REACTORS IN THE FEDERAL REPUBLIC OF GERMANY (1964) (0)
Study of molecular motions by neutron spectroscopy in organic solids (Review) (1972) (0)
Immunoaffinity Chromatography (1996) (0)
Immunoaffinity Chromatography (1996) (0)
Immunoaffinity Chromatography (1998) (0)
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change (2022) (0)
Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling (2022) (0)
Conformational change of the Plasmodium TRAP I domain is essential for sporozoite migration and transmission of malaria (2022) (0)
Dispositif et procede d'analyse de leucocytes sanguins roulants et d'identification d'inhibiteurs et de promoteurs (1992) (0)
Crystal Structure of the intermediate affinity aL I domain mutant (2003) (0)

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