Titia de Lange | Academic Influence

Titia de Lange's AcademicInfluence.com Rankings

Titia de Lange

Biology

#791

World Rank

#1369

Historical Rank

Genetics

#250

World Rank

#300

Historical Rank

biology Degrees

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Biology

Titia de Lange's Degrees

PhD Biochemistry University of Amsterdam

Why Is Titia de Lange Influential?

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According to Wikipedia, Titia de Lange is the Director of the Anderson Center for Cancer Research, the Leon Hess professor and the head of Laboratory Cell Biology and Genetics at Rockefeller University. De Lange obtained her Masters on "Chromatin structure of the human β-globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in 1985 with Piet Borst on surface antigen genes in trypanosomes. In 1985 she joined Harold Varmus's lab at the University of California, San Francisco. Since 1990 she has had a faculty position at the Rockefeller University. In 2011, de Lange received the Vilcek Prize in Biomedical Science. In 2013 she won a Breakthrough Prize in Life Sciences, worth $3 million, for her research on telomeres.

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Titia de Lange's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mammalian Telomeres End in a Large Duplex Loop (1999) (2429)
How shelterin protects mammalian telomeres. (2008) (1751)
TRF2 Protects Human Telomeres from End-to-End Fusions (1998) (1727)
Shelterin: the protein complex that shapes and safeguards human telomeres (2005) (1727)
Shelterin: the protein complex that shapes and safeguards human telomeres. (2005) (1485)
DNA Damage Foci at Dysfunctional Telomeres (2003) (1404)
Control of telomere length by the human telomeric protein TRF1 (1997) (1218)
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (1999) (1131)
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. (1998) (1030)
Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2 (1997) (950)
Protection of mammalian telomeres (2002) (920)
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication (2009) (903)
Structure and variability of human chromosome ends (1990) (864)
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 (2007) (847)
Regulation of telomerase by telomeric proteins. (2004) (842)
Senescence Induced by Altered Telomere State, Not Telomere Loss (2002) (808)
Control of Human Telomere Length by TRF1 and TRF2 (2000) (799)
Telomerase activity in normal and malignant hematopoietic cells. (1995) (760)
POT1 as a terminal transducer of TRF1 telomere length control (2003) (729)
A Human Telomeric Protein (1995) (703)
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres (2000) (657)
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion (2005) (629)
Identification of Human Rap1 Implications for Telomere Evolution (2000) (624)
53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection (2013) (573)
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility (2008) (565)
T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang (2001) (563)
How Telomeres Solve the End-Protection Problem (2009) (558)
Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres (2004) (542)
Removal of Shelterin Reveals the Telomere End-Protection Problem (2012) (525)
Different telomere damage signaling pathways in human and mouse cells (2002) (503)
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway (2012) (492)
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. (2004) (478)
Chromothripsis and Kataegis Induced by Telomere Crisis (2015) (476)
Telomeres in cancer: tumour suppression and genome instability (2017) (445)
Tankyrase promotes telomere elongation in human cells (2000) (442)
Definition of regions in human c-myc that are involved in transformation and nuclear localization (1987) (436)
Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres (2006) (426)
Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation (2013) (411)
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. (2003) (410)
The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response (2004) (401)
DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2 (2002) (392)
The causes and consequences of polyploidy in normal development and cancer. (2011) (377)
TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres* (2004) (373)
TRF1 is a dimer and bends telomeric DNA (1997) (371)
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end (2005) (337)
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination (2006) (326)
T-loops and the origin of telomeres (2004) (325)
53BP1: pro choice in DNA repair. (2014) (312)
How Telomeres Solve the End-Protection Problem (2009) (306)
A mammalian factor that binds telomeric TTAGGG repeats in vitro (1992) (286)
Shelterin-Mediated Telomere Protection. (2018) (273)
Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST (2012) (273)
A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins (2008) (267)
Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy (2010) (264)
For better or for worse. (1991) (262)
Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal (2010) (261)
Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex (1996) (247)
t‐loops at trypanosome telomeres (2001) (246)
53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in (2018) (241)
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence (2004) (238)
Unusual chromatin in human telomeres (1994) (237)
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. (2001) (232)
An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome. (1982) (230)
Human telomeres are attached to the nuclear matrix. (1992) (227)
53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair (2015) (227)
Tel2 Regulates the Stability of PI3K-Related Protein Kinases (2007) (220)
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. (2004) (220)
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex (2004) (219)
TRF1 binds a bipartite telomeric site with extreme spatial flexibility (1999) (217)
In Vivo Stoichiometry of Shelterin Components* (2009) (216)
Telomere protection by TPP1/POT1 requires tethering to TIN2. (2011) (212)
Activation of telomerase in a human tumor. (1994) (211)
Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. (1999) (206)
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. (2012) (201)
Stringent sequence requirements for the formation of human telomeres. (1994) (198)
Shelterin-Mediated Telomere Protection (2018) (193)
Rap1 affects the length and heterogeneity of human telomeres. (2003) (191)
Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1 (2003) (190)
DNA Binding Features of Human POT1 (2004) (187)
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. (2010) (181)
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. (2010) (169)
Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S Phase (2006) (168)
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation (1996) (160)
10 Telomere Dynamics and Genome Instability in Human Cancer (1995) (160)
TRF1 promotes parallel pairing of telomeric tracts in vitro. (1998) (159)
Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. (2000) (157)
Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome (1982) (151)
Ku Binds Telomeric DNA in Vitro * (1999) (146)
Apollo contributes to G overhang maintenance and protects leading-end telomeres. (2010) (146)
Telomere protection by mammalian Pot1 requires interaction with Tpp1 (2007) (145)
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling (2014) (141)
RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. (1982) (133)
53BP1: a DSB escort (2020) (132)
Functional Dissection of Human and Mouse POT1 Proteins (2008) (130)
Mammalian Rif1 contributes to replication stress survival and homology-directed repair (2009) (129)
Telomere Protection by TPP1 Is Mediated by POT1a and POT1b (2009) (128)
Control of telomere length by the human telomeric protein TRF1 (1997) (128)
The role of double-strand break repair pathways at functional and dysfunctional telomeres. (2014) (127)
For Better or Worse? Telomerase Inhibition and Cancer (1999) (125)
Telomere-related genome instability in cancer. (2005) (124)
Human telomeres are attached to the nuclear matrix. (1992) (121)
Engineered telomere degradation models dyskeratosis congenita. (2008) (121)
Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. (2006) (119)
Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species. (1984) (116)
TRF1, a mammalian telomeric protein. (1997) (115)
A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis. (1991) (114)
Telomeres and Senescence: Ending the Debate (1998) (111)
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. (2015) (110)
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. (2008) (109)
How shelterin solves the telomere end-protection problem. (2010) (108)
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. (2006) (107)
Discontinuous synthesis of mRNA in trypanosomes. (1984) (103)
Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2 (2009) (101)
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. (2010) (99)
Tandem repetition of the 5′ mini-exon of variant surface glycoprotein genes: A multiple promoter for VSG gene transcription? (1983) (99)
Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. (1997) (96)
T-loops and the origin of telomeres (2004) (95)
p16INK4a as a Second Effector of the Telomere Damage Pathway (2005) (92)
Activation of telomerase in a human tumor. (1994) (92)
Telomere protection by mammalian Pot1 requires interaction with Tpp1. (2009) (91)
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs (2020) (90)
Telomeres and Senescence: Ending the Debate (1998) (87)
Telomere-related genome instability in cancer. (2005) (81)
Many trypanosome messenger RNAs share a common 5' terminal sequence. (1984) (78)
POT 1-interacting protein PIP 1 : a telomere length regulator that recruits POT 1 to the TIN 2 / TRF 1 complex (2004) (78)
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis (2020) (74)
Role of 53BP1 oligomerization in regulating double-strand break repair (2013) (73)
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus (2016) (73)
Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. (2016) (71)
A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. (1993) (66)
NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. (2001) (64)
TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1 (2014) (64)
Telomere conversion in trypanosomes. (1983) (62)
TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. (2014) (62)
Telomere Capping--One Strand Fits All (2001) (61)
The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the Shelterin Complex* (2007) (60)
Telomere Recognition and Assembly Mechanism of Mammalian Shelterin. (2017) (60)
TRF2 binds branched DNA to safeguard telomere integrity (2017) (58)
Unlimited Mileage from Telomerase? (1999) (57)
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice (2014) (54)
53 BP 1 : Pro Choice in DNA Repair (2014) (50)
How shelterin solves the telomere end-protection problem. (2010) (46)
A TRF1-controlled common fragile site containing interstitial telomeric sequences (2012) (45)
The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction (2017) (44)
Protection of mammalian telomeres (2002) (43)
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. (2016) (43)
No Overt Nucleosome Eviction at Deprotected Telomeres (2008) (43)
Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection* (2014) (39)
Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G 1 and Resection-Mediated Inhibition of NHEJ in G 2 † (2009) (39)
Ending up with the right partner (1998) (39)
The control of variant surface antigen synthesis in trypanosomes. (1983) (39)
Shelterin (2016) (39)
Rap1-independent telomere attachment and bouquet formation in mammalian meiosis (2011) (38)
A new connection at human telomeres: association of the Mre11 complex with TRF2. (2000) (36)
A loopy view of telomere evolution (2015) (36)
Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb (2017) (35)
Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei. (1987) (35)
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity (2020) (34)
Break-induced replication promotes fragile telomere formation (2020) (34)
Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b (2018) (29)
Telomeric structure in cells with chromosome end associations (2004) (29)
53 BP 1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair Graphical (29)
Ending up with the right partner (1998) (29)
Significant Role for p 16 INK 4 a in p 53-Independent Telomere-Directed Senescence (2004) (27)
Transcription of a transposed trypanosome surface antigen gene starts upstream of the transposed segment. (1985) (26)
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. (2006) (26)
Taking apart Rap1 (2010) (25)
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. (2006) (25)
Rapid change of the repertoire of variant surface glycoprotein genes in trypanosomes by gene duplication and deletion. (1986) (24)
Characterization of t-loop formation by TRF2 (2020) (24)
The role of ferritin in developing primary bean leaves under various light conditions (1981) (24)
Cell biology. Telomere capping--one strand fits all. (2001) (24)
Risk factors for placental abruption in a socio-economically disadvantaged region (2007) (23)
A loopy view of telomere evolution (2015) (23)
The Role of the Poly(ADP-ribose) Polymerase Tankyrase1 in Telomere Length Control by the TRF1 Component of the (2007) (20)
Telomere biology and DNA repair: enemies with benefits. (2010) (18)
TINF2 is a haploinsufficient tumor suppressor that limits telomere length (2020) (18)
53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in (2018) (17)
Energy requirement for maintenance of the transmembrane potassium gradient in Klebsiella aerogenes NCTC 418: A continuous culture study (1979) (17)
53BP1/shieldin-dependent DSB processing in BRCA1-deficient cells requires CST/Polα/primase fill-in synthesis (2021) (17)
PHF11 promotes DSB resection, ATR signaling, and HR (2017) (16)
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state (2021) (16)
APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis (2019) (16)
Chromosomal mapping of the tankyrase gene in human and mouse. (1999) (15)
Telomerase Regulation at the Telomere A Binary Switch (2004) (15)
Novel patterns of complex structural variation revealed across thousands of cancer genome graphs (2019) (14)
Telomere Protection by TPP 1 Is Mediated by POT 1 a and POT 1 b (2010) (14)
Properties and regulation of synthesis of the glycerol dehydrogenase present in Klebsiella aerogenes NCTC 418, growing in chemostat culture (1978) (13)
The evolution of metazoan shelterin (2021) (12)
Structural variant evolution after telomere crisis (2020) (10)
In search of vertebrate telomeric proteins (1996) (9)
TRF 2-Tethered TIN 2 Can Mediate Telomere Protection by TPP 1 / POT 1 (2014) (9)
Lasker Laurels for Telomerase (2006) (8)
German population data of three tetrameric short tandem repeat loci--D3S1744, D12S1090 and D18S849. (1998) (8)
TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. (2017) (7)
Shelterin is a dimeric complex with extensive structural heterogeneity (2022) (6)
Telomere biology and DNA repair: Enemies with benefits (2010) (6)
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF 2 (2008) (5)
Length control of human telomeres. (1998) (5)
A TRF1-controlled common fragile site containing interstitial telomeric sequences (2012) (4)
What I got wrong about shelterin. (2018) (4)
Human Telomerase Caught in the Act (2009) (4)
Affordability of Healthy and Sustainable Diets in Nigeria (2021) (3)
Engineered telomere degradation models dyskeratosis congenita data (2008) (3)
TPP 1 Blocks an ATR-Medi ated Resection Mechanism at Telomeres Graphical Abstract Highlights (2016) (3)
What I got wrong about shelterin (2018) (3)
mTOR and ATR complexes Tel 2 structure and function in the Hsp 90-dependent maturation of Material Supplemental (2010) (3)
TRF1 uses a noncanonical function of TFIIH to promote telomere replication (2022) (3)
Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP 1 / Lig 3-Dependent End-Joining Graphical (2)
Structure andVariability ofHumanChromosome Ends (1990) (2)
Telomere Capping--One Strand Fits All (2001) (2)
Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. (2017) (2)
The molecular biology of antigenic variation in trypanosomes: gene rearrangements and discontinuous transcription. (1986) (2)
CST/Polα/primase-mediated fill-in synthesis at DSBs (2022) (2)
Faculty Opinions recommendation of Extensive allelic variation and ultrashort telomeres in senescent human cells. (2003) (1)
How telomeres solve the chromosome end‐protection problem (2018) (1)
Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. (2021) (1)
Addendum: T-loops and the origin of telomeres (2004) (1)
remain viable and regenerate liver mass through endoreduplication Hepatocytes with extensive telomere deprotection and fusion (2006) (1)
The Dilemmas of Water Quality and Food Security Interactions in Low- and Middle-Income Countries (2021) (1)
Loose ends in cancer genome structure (2021) (1)
Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex (2008) (0)
Telomeres: Protection and Maintenance (2005) (0)
Understanding and Targeting the ALT Pathway in Human Breast Cancer (2013) (0)
Corrigendum (2019) (0)
Advisory Board and Contents (2021) (0)
Rate my Editor (2023) (0)
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis (2020) (0)
Protection by TPP 1 / POT 1 TRF 2-Tethered TIN 2 Can Mediate Telomere (2014) (0)
Nucleic Acids Research (2008) (0)
Neotelomere formation by human telomerase (2022) (0)
New editorial board members (1995) (0)
Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex (2008) (0)
Dysfunctional Telomeres The Role of Double-Strand Break Repair Pathways at Functional and (2014) (0)
Telomere repeat binding factor and diagnostic and therapeutic use thereof (1997) (0)
DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres (2023) (0)
Author Correction: Telomeres in cancer: tumour suppression and genome instability (2019) (0)
Author Correction: Telomeres in cancer: tumour suppression and genome instability (2019) (0)
ATR repression at telomeres by POT1a and POT1b: RPA exclusion and interference by CST (2018) (0)
Faculty Opinions recommendation of Closed chromatin loops at the ends of chromosomes. (2004) (0)
T-loops and the origin of telomeres (2004) (0)
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70. (2022) (0)
Telomere Crisis and Chromosome Shattering in Cancer Principal Investigator : (2015) (0)
13 Mammalian Telomeres (2006) (0)
For Better or Worse? Minireview Telomerase Inhibition and Cancer (1999) (0)
United States Patent ( 19 ) (2017) (0)
Lasker Laurels for telomerase. (2006) (0)
Faculty Opinions recommendation of Subnuclear shuttling of human telomerase induced by transformation and DNA damage. (2002) (0)
ATM and ATR Signaling Re gulate the Recruitment of Human Telomerase to Telomeres Graphical (0)
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis (2022) (0)
Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex (2008) (0)
Advisory Board and Contents (2020) (0)
Author response: TINF2 is a haploinsufficient tumor suppressor that limits telomere length (2020) (0)
Occupations on the map: Using a super learner algorithm to downscale labor statistics (2022) (0)

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