Todd Golub

Q: What Schools Are Affiliated With Todd Golub

Todd Golub is affiliated with the following schools: Massachusetts General Hospital, Harvard University, University of Pennsylvania, Yale University, Oregon State University, Carleton College, Stanford University, Massachusetts Institute of Technology, University of Chicago

Todd Golub's AcademicInfluence.com Rankings

Todd Golub

Biology

#1748

World Rank

#2844

Historical Rank

Genetics

#176

World Rank

#217

Historical Rank

biology Degrees

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Biology

Todd Golub's Degrees

Doctorate Medicine University of Pennsylvania

Why Is Todd Golub Influential?

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According to Wikipedia, Todd R. Golub is a professor of pediatrics at the Harvard Medical School, the Charles A. Dana Investigator in Human Cancer Genetics at the Dana–Farber Cancer Institute, and the Director and a founding member of the Broad Institute of MIT and Harvard. He is a world leader in applying genomic tools to cancer research, having made important discoveries in the molecular basis of childhood leukemia.

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Todd Golub's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles (2005) (33800)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. (1999) (12024)
MicroRNA expression profiles classify human cancers (2005) (9561)
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes (2003) (6859)
The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity (2012) (6062)
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. (2010) (5816)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways (2008) (5775)
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease (2006) (4224)
The landscape of somatic copy-number alteration across human cancers (2010) (3297)
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. (1999) (3275)
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. (2005) (2933)
Mutational heterogeneity in cancer and the search for new cancer-associated genes (2013) (2852)
Mutational heterogeneity in cancer and the search for new cancer genes (2013) (2691)
Gene expression correlates of clinical prostate cancer behavior. (2002) (2549)
Discovery and saturation analysis of cancer genes across 21 tumor types (2014) (2530)
A molecular signature of metastasis in primary solid tumors (2003) (2476)
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning (2002) (2443)
Prediction of central nervous system embryonal tumour outcome based on gene expression (2002) (2421)
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma (2011) (2301)
Multiclass cancer diagnosis using tumor gene expression signatures (2001) (2107)
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals (2005) (1975)
Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data (2003) (1757)
Metagenes and molecular pattern discovery using matrix factorization (2004) (1750)
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles (2017) (1706)
Dissecting the Regulatory Circuitry of a Eukaryotic Genome (1998) (1585)
Next-generation characterization of the Cancer Cell Line Encyclopedia (2019) (1561)
Impaired microRNA processing enhances cellular transformation and tumorigenesis (2007) (1531)
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses (2001) (1518)
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion (2012) (1516)
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia (2002) (1509)
Genomic analysis of metastasis reveals an essential role for RhoC (2000) (1508)
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma (2005) (1458)
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 (2006) (1433)
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. (2001) (1413)
Initial genome sequencing and analysis of multiple myeloma (2011) (1385)
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer (2012) (1367)
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia (2006) (1325)
BRAF mutation predicts sensitivity to MEK inhibition (2006) (1323)
Defining a Cancer Dependency Map (2017) (1307)
Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation (1994) (1259)
The genomic complexity of primary human prostate cancer (2010) (1195)
Gene expression in fixed tissues and outcome in hepatocellular carcinoma. (2008) (1158)
Sequence analysis of mutations and translocations across breast cancer subtypes (2012) (1133)
Punctuated Evolution of Prostate Cancer Genomes (2013) (1105)
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. (2002) (1105)
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. (2011) (1098)
Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells (2017) (1096)
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. (2006) (1079)
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. (2010) (1068)
Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study (2008) (1063)
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma (2007) (1052)
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (974)
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (2004) (955)
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. (2003) (952)
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing (2012) (932)
Stem cell gene expression programs influence clinical outcome in human leukemia (2011) (916)
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen (2007) (902)
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. (2009) (900)
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis (2011) (887)
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. (2000) (855)
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. (2014) (842)
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. (2003) (838)
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. (2004) (822)
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine (2017) (804)
Selective killing of cancer cells with a small molecule targeting stress response to ROS (2011) (803)
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. (1995) (787)
COT/MAP3K8 drives resistance to RAF inhibition through MAP kinase pathway reactivation (2010) (778)
Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability (2002) (735)
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma (2016) (731)
Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity (2013) (700)
Melanoma genome sequencing reveals frequent PREX2 mutations (2012) (695)
Chemosensitivity prediction by transcriptional profiling (2001) (663)
Altered microRNA expression in human heart disease. (2007) (649)
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. (2000) (639)
Copper induces cell death by targeting lipoylated TCA cycle proteins (2022) (638)
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq (2017) (612)
Highly parallel identification of essential genes in cancer cells (2008) (553)
The Drug Repurposing Hub: a next-generation drug library and information resource (2017) (552)
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. (2006) (549)
Genetic and transcriptional evolution alters cancer cell line drug response (2018) (536)
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. (2006) (501)
Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-κB activation by TNF-α is obligatory (2002) (489)
Whole exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer (2014) (479)
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression (2011) (471)
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors (2017) (469)
Dicer1 functions as a haploinsufficient tumor suppressor. (2009) (463)
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations (2008) (458)
A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer (2003) (444)
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. (2016) (436)
The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation (2002) (427)
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis (2005) (421)
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei (2002) (419)
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. (2003) (417)
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. (2004) (402)
Targetable genetic features of primary testicular and primary central nervous system lymphomas. (2014) (382)
The genomic landscape of pediatric Ewing sarcoma. (2014) (380)
MicroRNA-1 Negatively Regulates Expression of the Hypertrophy-Associated Calmodulin and Mef2a Genes (2009) (378)
DNA microarrays in clinical oncology. (2002) (378)
Patient-derived xenografts undergo murine-specific tumor evolution (2017) (375)
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia (2007) (371)
Subclass Mapping: Identifying Common Subtypes in Independent Disease Data Sets (2007) (369)
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq (2018) (368)
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia (1996) (366)
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer (2017) (365)
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH 1 , EGFR , and NF 1 Citation Verhaak (2010) (362)
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. (2012) (352)
Lin28 Enhances Tumorigenesis and is Associated With Advanced Human Malignancies (2009) (349)
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. (2008) (338)
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma (2014) (335)
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. (2014) (329)
MicroRNA miR-125a controls hematopoietic stem cell number (2010) (325)
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. (2006) (325)
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016) (324)
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. (1996) (324)
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. (2008) (322)
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (2014) (320)
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. (2002) (309)
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells (2016) (301)
Identifying the proteins to which small-molecule probes and drugs bind in cells (2009) (300)
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. (1998) (299)
Yolk sac angiogenic defect and intra‐embryonic apoptosis in mice lacking the Ets‐related factor TEL (1997) (297)
Modeling genomic diversity and tumor dependency in malignant melanoma. (2008) (294)
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model (2003) (292)
Molecular classification of multiple tumor types (2001) (291)
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription (1996) (291)
Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation (1991) (287)
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling (2020) (287)
Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation (2004) (282)
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. (2009) (273)
Estimating Dataset Size Requirements for Classifying DNA Microarray Data (2003) (272)
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers (2019) (271)
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. (2002) (267)
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. (2017) (267)
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. (2005) (261)
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma (2014) (259)
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. (2007) (255)
Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. (2002) (251)
Recurrent and functional regulatory mutations in breast cancer (2017) (249)
The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways (1996) (249)
Class prediction and discovery using gene expression data (2000) (248)
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State (2013) (243)
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration (2018) (241)
LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures (2014) (240)
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy (2009) (229)
Molecular sampling of prostate cancer: a dilemma for predicting disease progression (2010) (227)
c-Myc Is a Critical Target for C/EBPα in Granulopoiesis (2001) (225)
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. (2011) (223)
Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2012) (217)
Support vector ma-chine classification of microarray data (2000) (211)
A method for high-throughput gene expression signature analysis (2006) (211)
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. (2004) (209)
The Genomic Landscape of Juvenile Myelomonocytic Leukemia (2015) (204)
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. (2007) (203)
Simultaneous protection of tissue physicochemical properties using polyfunctional crosslinkers (2018) (193)
Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells (2004) (193)
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. (2010) (191)
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. (2012) (190)
Large-scale chemical dissection of mitochondrial function (2008) (190)
WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers (2018) (187)
Comprehensive assessment of cancer missense mutation clustering in protein structures (2015) (186)
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. (2006) (186)
Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. (2013) (185)
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. (2008) (185)
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells (2002) (183)
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease (2010) (181)
Integrative Genome Comparison of Primary and Metastatic Melanomas (2010) (179)
Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion (2012) (172)
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines (2016) (172)
An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome (2008) (170)
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. (2005) (166)
DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. (2017) (163)
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. (2013) (163)
Proteomic and genetic approaches identify Syk as an AML target. (2009) (162)
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (2014) (161)
Multiplex Cytological Profiling Assay to Measure Diverse Cellular States (2013) (160)
Mitochondrial metabolism promotes adaptation to proteotoxic stress (2019) (158)
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. (2012) (158)
High-throughput Phenotyping of Lung Cancer Somatic Mutations. (2016) (157)
Humanized mice with ectopic artificial liver tissues (2011) (154)
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling (2014) (151)
mRNA expression signature of Gleason grade predicts lethal prostate cancer. (2011) (150)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (148)
Abstract 1028: Patient-derived xenografts undergo mouse-specific tumor evolution (2018) (147)
Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma (2007) (143)
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (139)
Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer. (2018) (137)
Genomic evolution of cancer models: perils and opportunities (2018) (136)
A metastasis map of human cancer cell lines (2020) (136)
Genomic approaches to hematologic malignancies. (2004) (136)
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (135)
Gefitinib induces myeloid differentiation of acute myeloid leukemia. (2005) (133)
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling (2011) (133)
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map (2017) (133)
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. (2007) (132)
UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia (2002) (130)
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research (2019) (126)
Incidence of TEL/AML1 fusion in children with relapsed acute lymphoblastic leukemia. (1998) (125)
A resampling-based method for class discovery and visualization of gene expression microarray data (2003) (125)
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. (2016) (124)
Cas9 activates the p53 pathway and selects for p53-inactivating mutations (2020) (123)
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. (2011) (122)
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. (1996) (122)
LACTB is a tumour suppressor that modulates lipid metabolism and cell state (2017) (121)
Genetic interrogation of circulating multiple myeloma cells at single-cell resolution (2016) (121)
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets (2019) (120)
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity (2018) (117)
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. (2007) (116)
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease (2005) (114)
Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling. (2006) (111)
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. (1996) (110)
MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia. (2007) (109)
Epstein-Barr-Virus-Encoded LMP2A Induces Primary Epithelial Cell Migration and Invasion: Possible Role in Nasopharyngeal Carcinoma Metastasis (2005) (109)
TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. (1995) (108)
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. (2004) (106)
SF 3 B 1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia (2011) (106)
Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer. (2005) (103)
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. (2013) (102)
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. (2019) (102)
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (102)
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation (2008) (96)
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 (2017) (89)
Genome-wide views of cancer. (2001) (88)
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay (2017) (86)
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition (2021) (86)
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy (2019) (82)
microRNA Expression during Trophectoderm Specification (2009) (79)
MLL-rearranged leukemias: insights from gene expression profiling. (2003) (79)
Identification of an Evolutionarily Conserved Transcriptional Signature of CD8 Memory Differentiation That Is Shared by T and B Cells1 (2008) (78)
Fatty acid synthesis is required for breast cancer brain metastasis (2021) (78)
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability (2012) (77)
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action (2020) (76)
A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer (2004) (76)
Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies. (2006) (75)
An Analytical Method for Multiclass Molecular Cancer Classification (2003) (72)
Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer (2020) (69)
Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) (67)
Respiratory Failure Due to Differentiation Arrest and Expansion of Alveolar Cells following Lung-Specific Loss of the Transcription Factor C/EBPα in Mice (2006) (66)
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity (2014) (64)
Counterpoint: Data first (2010) (62)
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (62)
Drug and disease signature integration identifies synergistic combinations in glioblastoma (2018) (61)
In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions. (1990) (60)
An ecosystem of cancer cell line factories to support a cancer dependency map (2015) (60)
The TEL gene and human leukemia. (1996) (60)
Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers" (2007) (59)
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations (2017) (58)
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program (2011) (55)
Empirical Bayes Analysis of Quantitative Proteomics Experiments (2009) (55)
Noncanonical open reading frames encode functional proteins essential for cancer cell survival (2021) (54)
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells. (2008) (53)
The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms. (1997) (52)
Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution. (2007) (52)
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling (2017) (51)
Identification of AML1-ETO modulators by chemical genomics. (2009) (48)
Genetic modifiers of EGFR dependence in non-small cell lung cancer (2014) (48)
A First-Generation Pediatric Cancer Dependency Map (2021) (48)
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma. (2015) (47)
Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer (2018) (46)
The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis (2016) (45)
High-throughput validation of ceRNA regulatory networks (2017) (45)
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. (2008) (44)
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. (2010) (43)
Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. (2015) (39)
Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas (2008) (38)
Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms. (1996) (35)
Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma (2012) (34)
Cancer research needs a better map (2021) (34)
The human genome at ten (2010) (34)
AACR Cancer Progress Report 2012 (2012) (33)
TEL gene rearrangements in myeloid malignancy. (1997) (32)
A Functional Screen Identifies miRs That Induce Radioresistance in Glioblastomas (2014) (29)
Expression Profiling of Archival Tumors for Long-term Health Studies (2012) (29)
Non-oncology drugs are a source of previously unappreciated anti-cancer activity (2019) (27)
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 (2015) (26)
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia. (2014) (26)
Application of Oligonucleotide Microarrays to Assess the Biological Effects of Neoadjuvant Imatinib Mesylate Treatment for Localized Prostate Cancer (2006) (26)
Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2015) (26)
Genomic approaches to the pathogenesis of hematologic malignancy (2001) (25)
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. (2019) (25)
Genome-scale screens identify factors regulating tumor cell responses to natural killer cells (2021) (25)
Gene expression-based screening for inhibitors of PDGFR signaling (2008) (24)
A strategy for oligonucleotide microarray probe reduction (2002) (24)
The Six 1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A 1 (2004) (22)
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. (2015) (22)
Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics (2020) (20)
Mining the genome for combination therapies (2003) (20)
Direct evidence for a polygenic etiology in familial multiple myeloma. (2017) (18)
The Metastatic Breast Cancer Project: A national direct-to-patient initiative to accelerate genomics research. (2016) (17)
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP (2019) (16)
Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (15)
Toward a functional taxonomy of cancer. (2004) (15)
Identification of prostate cancer modifier pathways using parental strain expression mapping (2007) (14)
Incidence of TEL / AML 1 Fusion in Children With Relapsed Acute Lymphoblastic Leukemia (1998) (14)
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q (2020) (14)
The Metastatic Breast Cancer (MBC) project: Accelerating translational research through direct patient engagement. (2017) (13)
High-throughput Phenotyping of Lung Cancer Somatic Mutations. (2016) (13)
Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine. (2022) (13)
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer (2019) (12)
Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth (2022) (12)
Supplementary Notes MicroRNA Expression Profiles Classify Human Cancers (2005) (11)
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. (2021) (10)
Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer (2020) (10)
correction: Genomic analysis of metastasis reveals an essential role for RhoC (2001) (10)
Growth and characterization of epithelial cells from normal human uterine ectocervix and endocervix (1989) (9)
Comprehensive Genetic Interrogation of Circulating Multiple Myeloma Cells at Single Cell Resolution (2016) (9)
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma (2022) (9)
Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations (2020) (8)
Genomics: Global views of leukaemia (2007) (8)
Duplex-Repair enables highly accurate sequencing, despite DNA damage (2021) (7)
lymphoma sclerosing Hodgkin lymphoma and primary mediastinal large B-cell PD-1 ligand expression, and further induction via JAK2 in nodular Integrative analysis reveals selective 9p24.1 amplification, increased (2010) (7)
Syk Is a New Target for AML Differentiation. (2007) (7)
TEL and KIP 1 Define the Smallest Region of Deletions on 1 2 ~ 1 3 in Hematopoietic Malignancies (2000) (7)
DNA-based copy number analysis confirms genomic evolution of PDX models (2021) (7)
Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2018) (6)
IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas. (2007) (6)
Discovery of Inhibitors of Anti-Apoptotic Protein A1 (2011) (6)
Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint (2020) (6)
Santagata Supports the Anabolic Malignant State Tight Coordination of Protein Translation and HSF 1 Activation (2014) (5)
Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action (2019) (5)
Abstract 5455: Integrative analysis of the Cancer Cell Line Encyclopedia reveals genetic and transcriptional predictors of compound sensitivity (2011) (5)
Fusion of platelet-derived growth receptor {beta} to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation (1994) (5)
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q (2021) (4)
Expression Profiling of EWS/FLI Identifies NKX2.2 as a Critical Target Gene in Ewing's Sarcoma (DOI: 10.1016/j.ccr.2006.04.004) (2007) (4)
Corrigendum: Gene expression–based high-throughput screening (GE-HTS) and application to leukemia differentiation (2004) (4)
CXCR4 pathway associated with family history of melanoma (2013) (4)
A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia. (2005) (4)
Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress (2019) (4)
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (4)
application to hematopoietic differentiation Interpreting patterns of gene expression with self-organizing maps: Methods and (2007) (4)
Count me in: A patient-driven research initiative to accelerate cancer research. (2018) (4)
Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal (2022) (4)
The Angiosarcoma Project: Generating the genomic landscape of a rare cancer through a direct-to-patient initiative. (2017) (4)
Non-canonical open reading frames encode functional proteins essential for cancer cell survival (2020) (4)
Golub , Monitoring and Class Prediction by Gene Expression Molecular Classification of Cancer : Class Discovery (2007) (3)
Correction: Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia (2016) (3)
Reply to "Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population" and "Genetic background is an important determinant of metastatic potential" (2003) (3)
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity (2018) (3)
Gefitinib (Iressa) induces myeloid differentiation of acute myeloid leukemia (2005) (3)
The Mutational Landscape of Diffuse Large B Cell Lymphoma (2011) (3)
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity (2012) (2)
Abstract 5371: The Metastatic Breast Cancer Project: Partnering with patients to accelerate progress in cancer research (2018) (2)
Abstract B085: High mutation burden and response to immune checkpoint inhibitors in angiosarcomas of the scalp and face (2019) (2)
Abstract 999: The genomic landscape of pediatric Ewing sarcoma (2014) (2)
HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma. (2009) (2)
Oncogenomics: cancer and technology (2002) (2)
Genetic and transcriptional evolution alters cancer cell line drug response (2018) (2)
Abstract 2996: Overexpression of potential oncogenic microRNAs defines a new molecular subclass of hepatocellular carcinoma (2010) (2)
Erratum: Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-α (Diabetes (2002) 51 (3176-3188)) (2003) (2)
High Throughput Screen To Identify Small Molecules That Differentially Regulate Expression of the Globin Genes. (2005) (2)
Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers (2019) (2)
Abstract 993: Whole exome sequencing of CTCs as a window into metastatic cancer (2014) (2)
Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis (2021) (2)
Frequent Loss of Heterozygosity on Chromosomes 6q, 9p, 11q or 12p in Childhood Acute Lymphoblastic Leukemia (1998) (2)
Systematic profiling of conditional degron tag technologies for target validation studies (2022) (2)
Molecular proﬁling of diffuse large B-cell lymphoma identiﬁes robust subtypes including one characterized by host inﬂammatory response (2005) (2)
The Metastatic Prostate Cancer project (MPCproject): Translational genomics through direct patient engagement. (2018) (2)
Abstract PD4-08: A microenvironment secretome screen reveals FGF2 as a mediator of resistance to anti-estrogens and PI3K/mTOR pathway inhibitors in ER+ breast cancer (2018) (2)
Publisher Correction: A metastasis map of human cancer cell lines (2021) (2)
Characterization of Distinct Molecular Signatures in Myeloproliferative Diseases with the JAK2V617F Mutation and Wild Type JAK2. (2005) (2)
MAESTRO affords ‘breadth and depth’ for mutation testing (2021) (2)
Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1 (2011) (1)
Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry (2020) (1)
Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis (2017) (1)
Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma (2012) (1)
Corrigendum: Large-scale chemical dissection of mitochondrial function (2008) (1)
Abstract SY30-03: First impressions of the multiple myeloma genome (2010) (1)
Abstract P1-05-13: The metastatic breast cancer project: Translational genomics through direct patient engagement (2017) (1)
Corrigendum: Gene expression–based high-throughput screening (GE-HTS) and application to leukemia differentiation (2005) (1)
Malignant Melanoma Modeling Genomic Diversity and Tumor Dependency in Updated (2008) (1)
Abstract 4017: Dissecting the clonal hierarchy of cancer-driving genomic lesions. (2013) (1)
334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. (2016) (1)
Supplementary Material 10 (2014) (1)
Human Prostate Epithelial Cells Androgen-Induced Differentiation and Tumorigenicity of Updated (2004) (1)
Abstract 4837: Tumor microenvironment contributes to RAF-inhibitor resistance through HGF secretion (2012) (1)
Modulating AML1-ETO with Signature-Based Small Molecule Library Screening. (2006) (1)
716 PROGNOSTIC GENE-EXPRESSION SIGNATURE FOR HEPATITIS C-RELATED EARLY-STAGE LIVER CIRRHOSIS (2012) (1)
Abstract 105: Integrative analysis of genomic and pharmacologic data from the Cancer Cell Line Encyclopedia (2010) (1)
Genetically-Defined Diffuse Large B-Cell Lymphoma Subsets Arise By Distinct Pathogenetic Mechanisms and Predict Outcome (2017) (1)
Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines (2013) (1)
Prolonged therapy for hepatitis C with low-dose peginterferon. (2009) (1)
An Erythroid Differentiation Gene Expression Signature Predicts Response to Lenalidomide in Myelodysplasia. (2006) (1)
Mir-15a/16-1 Cluster Is Frequently Deleted In Primary Hodgkin Lymphoma and Modulates Multiple Survival Pathways Including AP-1 (2010) (1)
Abstract 2352: Defining a pediatric cancer dependency map (2018) (1)
The Somatic Cancer Genome (2014) (1)
Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (1)
Abstract 606: Targeting the immune checkpoint PTPN2 with ABBV-CLS-484 inflames the tumor microenvironment and unleashes potent CD8+ T cell immunity (2022) (1)
Hodgkin’s Lymphoma Reed Sternberg Cells over Express the T-Cell Inhibitory Carbohydrate-Binding Lectin, Galectin 1: Role of AP-1 and Likely Mechanism of Tumor Immune Escape. (2006) (1)
High-throughput validation of ceRNA regulatory networks (2017) (1)
Abstract 5384: The Angiosarcoma Project: Generating the genomic landscape of an exceedingly rare cancer through a nationwide patient-driven initiative (2018) (1)
A Molecular Signature of the Transcription Factor GATA1 in Acute Megakaryoblastic Leukemia of Childhood. (2004) (1)
Geﬁtinib induces myeloid differentiation of acute myeloid leukemia (2005) (1)
Abstract PR02: Towards a Cancer Dependency Map (2017) (1)
MetMap: a map of metastatic potential of human cancer cell lines (2020) (1)
Dithiophenes potentiate differentiation of APL cells by lowering the threshold for ligand mediated co-repressor/co-activator exchange with RAR alpha and enhancing changes in ATRA regulated gene expression. (2003) (1)
Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics (2011) (1)
Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection (2017) (1)
Transcriptional Mapping of T Cell Memory Reveals That Chronic Viral Infection Arrests Memory Differentiation. (2005) (0)
Identification of Small Molecules Selectively Targeting Leukemic Stem Cells within Their Stromal Niche (2012) (0)
Abstract 1712: Transmembrane domain required for MCL1 function. (2013) (0)
miR-126 Regulates Distinc t Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells Graphical (0)
Figure 1.5, [Constructing a genomic library. Genomic...]. (2000) (0)
Abstract PR04: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function (2015) (0)
Abstract PR007: A liposomal priming agent increases the sensitivity of liquid biopsies (2023) (0)
Abstract B26: Accelerating prediction of tumor vulnerabilities using next-generation cancer models (2016) (0)
DNA Damage and Repair A Functional Screen Identi fi es miRs That Induce Radioresistance in Glioblastomas (2014) (0)
am plification of CRKL in duces t r ansformation and ep idermal Growth Factor r e ceptor in hibitor r e sistance in hu man Non- s m all ce ll lu ng ca ncers (2011) (0)
Abstract 5114: Integrative analysis of the Cancer Cell Line Encyclopedia reveals genetic and transcriptional predictors of compound sensitivity (2012) (0)
Aberrant activation of spleen tyrosine kinase in ovarian cancer identified through a global phosphorylation profiling of protein tyrosine kinases (2012) (0)
Abstract 90: Fatty acid synthesis is required for breast cancer brain metastasis (2021) (0)
The Prostate Cancer Project (PC Project): Translational genomics through direct patient engagement. (2017) (0)
Abstract 4601: Punctuated evolution of prostate cancer genomes. (2013) (0)
Leveraging the power for genomics for immuno-oncology (2021) (0)
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research (2020) (0)
Selective Targeting of Leukemic Over Normal Stem Cells by the Serotonin Receptor Antagonist SB-216641 (2011) (0)
Abstract PO041: Landscape of molecular events regulating tumor cell responses to natural killer cells (2021) (0)
Diagnostic de tumeur cerebrale et prediction de resultat de traitement (2002) (0)
Cloning and characterization of the t(5; 12) translocation breakpoint associated with chronic myelomonocytic leukemia (CMML) (1994) (0)
Small-molecule and CRISPR screening converge to reveal RTK dependencies in pediatric rhabdoid tumors (2020) (0)
Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers with chromosome 18q or 16q deletion (2020) (0)
Next-generation characterization of the Cancer Cell Line Encyclopedia (2019) (0)
Abstract 4822: Analysis of somatic copy number alterations associated with poor prognosis and progression of multiple myeloma in African Americans (2010) (0)
A Structural Basis for p53-Deficiency, Deregulated Cell Cycle and Unfavorable Outcome in Diffuse Large B-Cell Lymphoma (2012) (0)
leukemic cells Id1 is a common downstream target of oncogenic tyrosine kinases in (2013) (0)
Abstract OT2-05-03: The metastatic breast cancer project: A national direct-to-patient research initiative to accelerate genomics research (2016) (0)
Study of genetic alterations in soft tissue sarcomas by SNP arrays, expression profiling and high-throughput sequencing (2007) (0)
MLL-Fusion Proteins Induce a Stem Cell Program in Committed Progenitors To Generate Leukemia Stem Cells. (2005) (0)
Publisher Correction: DNA-based copy number analysis confirms genomic evolution of PDX models (2022) (0)
HG-110SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HEMISPHERIC AND MIDLINE HIGH-GRADE GLIOMAS. (2016) (0)
Abstract 3931: Whole genome and whole exome sequencing of head and neck cancer (2011) (0)
RBIO-05. miRNAs THAT CONFER GLIOBLASTOMA RESISTANCE: IS THE COMBINATION MERELY A SUM OF THE PARTS? (2016) (0)
Abstract 2028: PDE3A modulation for cancer therapy (2017) (0)
Abstract B64: Analysis of somatic copy number alterations among African American patients with multiple myeloma using array CGH (2010) (0)
Supplementary Material 8 (2013) (0)
Abstract PD8-01: The metastatic breast cancer project: Generating the clinical and genomic landscape of metastatic breast cancer through patient-partnered research (2020) (0)
Specific dithiophene analogs potentiate ATRA induction of acute promyelocytic leukemia cell differentiation and gene expression in vivo. (2002) (0)
Chapter 3 – Genomic Approaches to Hematology (2018) (0)
GENT-16. REDEFINING THE CELLULAR ARCHITECTURE OF ADULT AND PEDIATRIC GLIOBLASTOMAS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES (2016) (0)
Abstract PR12: High-throughput gene expression profiling as a generalizable assay for determination of mutation impact on gene function (2015) (0)
Abstract C022: Large scale phenotypic screening using PRISM, integrated with functional genomic screening and transcriptional profiling accelerates target identification of cytotoxic small molecules (2019) (0)
NFκB Activation in Primary Mediastinal Large B-Cell Lymphoma: Nuclear Localization of c-REL and Coordinate Upregulation of NFκB Target Genes. (2004) (0)
Biomarkers for detecting pre-cachexia or cachexia and methods of treatment thereof (2014) (0)
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling (2017) (0)
Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS (2018) (0)
DDRE-07. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS (2021) (0)
TEL/ETV6 Gene Rearrangements in Human Leukemias (2002) (0)
Abstract B13: Human pancreatic cancer organoids for functional dependency profiling (2016) (0)
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration (2018) (0)
Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030 (2023) (0)
TITLE: Sensitive detection of minimal residual disease in patients treated for early- 1 stage breast cancer 2 (2020) (0)
with classical Hodgkin lymphoma from that of other diffuse large B-cell lymphomas and shares features The molecular signature of mediastinal large B-cell lymphoma differs (2013) (0)
Publisher Correction: A metastasis map of human cancer cell lines (2021) (0)
Abstract PR4: Integrative analysis of genomic and pharmacologic data from the Cancer Cell Line Encyclopedia (2010) (0)
Abstract B121: An oncogene-linked prodrug strategy in lung cancer (2019) (0)
Abstract 1271: Aberrant activation of Spleen Tyrosine Kinase in ovarian cancer identified through a global phosphorylation profiling of protein tyrosine kinases (2012) (0)
Application of OligonucleotideMicroarrays toAssess the Biological Effects of Neoadjuvant ImatinibMesylateTreatment for Localized Prostate Cancer (2005) (0)
All Memory Lymphocytes Share a Common Differentiation Program. (2006) (0)
Cas9 activates the p53 pathway and selects for p53-inactivating mutations (2020) (0)
Genomc-Wide Profiling of Gene Expression and DNA Copy Number Alterations in Multiple Myeloma. (2007) (0)
LG-001. OPTIC PATHWAY GLIOMAS; FROM CHILDHOOD TO ADULTHOOD (2014) (0)
The Drug Repurposing Hub: a next-generation drug library and information resource (2017) (0)
Abstract A41: Small molecule inhibition of PTPN2/1 inflames the tumour microenvironment and unleashes potent CD8+ T cell immunity (2022) (0)
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity. (2023) (0)
Abstract 3400: Adenosine receptor antagonists exhibit potent and selective off-target killing of FOXA1-high cancers (2020) (0)
A High-Throughput Arrayed Lentiviral RNAi Screen To Identify Novel Oncogenes in Multiple Myeloma. (2007) (0)
EXTH-37. TARGETING EPIGENETIC VULNERABILITIES IDENTIFIED FROM A CRISPR SCREEN IN H3.3K27M DIPG (2020) (0)
1314 RECURRENT MUTATIONS IN SPOP DEFINE A DISTINCT MOLECULAR CLASS OF PROSTATE CANCER (2012) (0)
Abstract PO-031: MetMap: A map of metastatic potential of human cancer cell lines (2020) (0)
Identification and Validation of Molecular Markers of Tumor Cell Resistance to Natural Killer Cells through CRISPR-Based Screens and Large-Scale Phenotypic Screens of Pooled Tumor Cell Lines (2017) (0)
Abstract A02: Expanding tumor chemical-genetic interaction map using next-generation cancer models (2017) (0)
Mediastinal Large B-Cell Lymphoma : A unique subset of diffuse large B-cell lymphoma with an expression signature resembling that of Hodgkin ’ s Reed-Sternberg Cells (2004) (0)
Generation of Programmable Cell Lines and Single-domain Antibodies to Study the Inflammasome Response (2017) (0)
Genomics and Systems Biology. (2008) (0)
FDX1 regulates cellular protein lipoylation through direct binding to LIAS (2023) (0)
DDRE-04. THE COMBINED TREATMENT OF L-ASPARAGINASE AND 6-DIAZO-5-OXO-L-NORLEUCINE INHIBIT THE PROLIFERATION OF TEMOZOLOMIDE-SENSITIVE OR RESISTANT GLIOBLASTOMA CELLS (2021) (0)
The landscape of chromosomal aberrations in mouse models of breast cancer reveals driver-specific routes to tumor development (2016) (0)
GENE-22. RE-PROGRAMING CHROMATIN WITH A BIFUNCTIONAL LSD1/HDAC INHIBITOR INDUCES THERAPEUTIC DIFFERENTIATION IN DIPG (2018) (0)
Abstract IA05: Genomic approaches to drug discovery (2018) (0)
transcription.an activator to a repressor of The t(12;21) translocation converts AML-1B (2013) (0)
Leukemic and Normal Stem Cell Transcriptional Signatures Determined by Functional Assays Are Predictive of the Overall Survival of AML Patients. (2009) (0)
334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. (2016) (0)
Abstract A2-26: Reference pharmacologic class analysis for Connectivity Map discovery (2015) (0)
Transcriptional mapping of the anti-viral T cell response shows that impaired memory differentiation causes T cell dysfunction (2006) (0)
Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations (2020) (0)
Abstract 835: Downregulation Of Cardiomyocyte-enriched Micrornas Contributes To Altered Gene Expression In Heart Failure (2007) (0)
Abstract OT-18-01: The metastatic breast cancer project: Generating the clinical and genomic landscape of metastatic breast cancer through patient-partnered research (2021) (0)
Quantum Dot Based Duplex In Situ Hybridisation for Gene Expression Profiling. (2005) (0)
Abstract 957: Towards precision functional genomics via next-generation functional mapping of cancer variants (2015) (0)
Abstract 923: Separating the wheat from the chaff: A first look at the Cancer Cell Lines Encyclopedia sequencing data (2011) (0)
Su.66. Memory T-Cells in Mice and Humans Share a Common Molecular Program of Differentiation Regardless of Phenotype, Lineage Or Species (2006) (0)
Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models (2017) (0)
Abstract 2620: The Cancer Cell Line Encyclopedia project: From integrative cancer genomics to personalized cancer therapy (2010) (0)
pathway activation in myeloproliferative neoplasm pathogenesis Integrated genomic analysis illustrates the central role of JAK-STAT (2014) (0)
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (0)
Abstract 2062: Selective gene dependencies inMYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry (2018) (0)
Abstract 5769: A novel, high-throughput approach to discovering drug-resistance genes identifies CRAF, CrkL, and TPL2/COT as drivers of resistance to BRAFV600E inhibition (2010) (0)
Abstract 1139: Complete characterization of prostate cancer genomes by massively parallel sequencing (2010) (0)
Identification of HPV 31B in human cervical cells grown on raised collagen gel rafts (1991) (0)
Abstract NG10: A metastasis map of human cancer cell lines (2021) (0)
CXCR4 pathway associated with family history of melanoma (2013) (0)
Binding affinity (K D ) of ligands to MCL1 and MBP-MCL1. (2015) (0)
TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL (2020) (0)
Clinical exposure of tumor-bearing mice to a statis magnetic field (1985) (0)
CODEC enables ‘single duplex’ sequencing (2021) (0)
Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer (2016) (0)
Altered microRNA expression in human heart disease Running Title: Altered miRNA expression in human heart disease (2007) (0)
Genomic evolution of cancer models: perils and opportunities (2018) (0)
Molecular profiling of diffuse large B-cell lymphoma reveals discrete clusters including one characterized by host inflammatory response (2004) (0)
Translocations de mll indiquant un profil d'expression genique distinct qui permet de distinguer une leucemie unique (2002) (0)
Multiple Myeloma Sequencing Reveals Subclonality and Timing of Genetic Alterations (2011) (0)
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (0)
The Multiple Myeloma Genomics Portal (2008) (0)
Abstract OT1-19-01: The metastatic breast cancer project: Generating the clinical and genomic landscape of metastatic breast cancer through patient-partnered research (2022) (0)
Drug and disease signature integration identifies synergistic combinations in glioblastoma (2018) (0)
Abstract PR07: Towards precision functional genomics via next-generation functional mapping of cancer variants (2015) (0)
MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations. (2007) (0)
Comprehensive Analyses of Genetic Features Identify Coordinate Signatures in Diffuse Large B-Cell Lymphoma (2015) (0)
Oncogenic Tyrosine Kinases Regulate Proliferative and Survival Signals through Activation of Id1. (2004) (0)
Massively-parallel enrichment of minor alleles for mutational testing via low-depth duplex sequencing (2022) (0)
PTPS-06SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HIGH-GRADE GLIOMA (2015) (0)
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP (2019) (0)
Diagnostic du cancer de la prostate et prevision des resultats d'un traitement par analyse de l'expression genetique (2002) (0)
Abstract 5559: Proteomic identification of activated, essential tyrosine kinases in human cancers (2010) (0)
Abstract P5-01-03: Ultrasensitive detection of minimal residual disease in patients treated for breast cancer (2020) (0)
Signatures of Response to the Proteasome Inhibitor Bortezomib in Diffuse Large B-Cell Lymphoma. (2005) (0)
functions as a haploinsufficient tumor suppressor Dicer 1 Material Supplemental (2009) (0)
Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (0)
Abstract 4025: Accelerating drug repurposing for cancer therapy using multiplexed viability assays (2017) (0)
Genome Maps: 11 The Human Genome (2001) (0)
The Multiple Myeloma Research Consortium Genomics Initiative. (2007) (0)
A strategy for oligonucleotide microarray probe reduction Citation (2002) (0)
Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers (2020) (0)
amplification of C RKL ind uces t ra nsformation and epi dermal Growth Factor r ec eptor inh ibitor r es istance in hum an Non- s ma ll cel l lun g can cers (2011) (0)
Abstract LB-330: Systematic understanding of tyrosine kinase activation pattern in human cancers (2011) (0)
Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease (2008) (0)
Abstract LB-257: Liquid biopsy versus tissue biopsy to assess acquired resistance and tumor heterogeneity in gastrointestinal cancers (2019) (0)
Abstract 3088: The efficient utilization of paracrine support from established cell lines for breast/ovarian cancer model generation (2022) (0)
Tight Coordination of Protein Translation and Heat Shock Factor 1 Activation Supports the Anabolic Malignant State (2013) (0)
WRN helicase is a synthetic lethal target in microsatellite unstable cancers (2019) (0)
Integrative Analysis Reveals Multiple Alterations of p53 Signaling Pathway Components In Primary Diffuse Large B-Cell Lymphomas (2010) (0)
Abnormal differentiation and hyperproliferation of alveolar cells in a mouse model of lung-specific deletion of the transcription factor C/EBPα (2005) (0)
Abstract LB-136: High concordance of whole-exome sequencing of cell-free DNA and matched biopsies enables genomic discovery in metastatic cancer (2016) (0)
Abstract 2925: Gene expression analysis to monitor erlotinib prevention of hepatocellular transformation during cirrhosis (2010) (0)
breast cell line AML Breast Colorectal Endometrium Esophagus Glioma Kidney Liver Lung ( NSCLC ) Medulloblastoma Melanoma Neuroblastoma Osteosarcoma Ovary Pancreas Soft tissue Stomach (2017) (0)
Abstract 2690: Massively parallel multiplexed methods to screen hundreds of barcoded cancer cell line models with small molecules or genetic perturbations using next-generation sequencing (2019) (0)
DNA Microarrays in Cl inica l Oncology (2002) (0)
Abstract 1883: Large scale viability screening with PRISM underscores non-inhibitory properties of small molecules (2022) (0)
Abstract 5056: A glimpse into the somatic mutation landscape of melanoma through exome sequencing of 121 tumor-normal pairs (2012) (0)
Abstract 4344: Integrative functional proteogenomics for unannotated or uncharacterized proteins in cancer (2019) (0)
Expression of Proliferation Related Genes in Myelodysplastic Syndromes (MDS) and Secondary Acute Myeloid Leukemia (AML) Patients with Resistance to Low Dose Vidaza and Thalidomide. (2006) (0)
Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers (2019) (0)
Abstract B44: Emerging targets from Cancer Dependency Map v0.1 (2017) (0)
Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing (2011) (0)
Abstract P3-03-01: A novel high-throughput secreted factor screen and bioinformatics pipeline identifies microenvironment-derived FGF2 as a mechanism of resistance to anti-estrogens, PI3K, and mTOR inhibitors in ER+ breast cancer (2017) (0)
DIPG-06. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES. (2017) (0)
Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes (2018) (0)
Abstract PD11-06: PD11-06 Circulating tumor DNA association with residual cancer burden after neoadjuvant therapy in triple negative breast cancer in TBCRC 030 (2023) (0)
tumor progression in a mouse model of lung cancer Chronic cisplatin treatment promotes enhanced damage repair and Material (2010) (0)
Abstract IA06: Genomic approaches to drug discovery (2017) (0)
SNP array based analyses of somatic genetic and the identification of MITF as a lineage survival oncogene amplified in malignant melanoma (0)
Abstract 2948: Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells (2019) (0)
An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies (2023) (0)
BIOL-03. PROTEIN TRANSLATION FROM NON-CODING GENOMIC LOCI PRODUCE BIOLOGICALLY-ACTIVE PROTEINS IMPLICATED IN CANCER CELL SURVIVAL IN PEDIATRIC BRAIN TUMORS (2021) (0)
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors (2017) (0)
Abstract PD6-02: The metastatic breast cancer project - Expanding the clinical, genomic, and transcriptomic landscape of metastatic breast cancer through patient-partnered research (2022) (0)
Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers (2022) (0)
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting (2022) (0)
as a Novel Tumor Suppressor in Lung Cancer β Factor 3 Binding Protein Targets Identifies Hepatocyte Nuclear A Transcriptional Profiling Study of CCAAT / Enhancer (2004) (0)
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting (2019) (0)
Abstract 506: ANJ810 is a highly selective novel MCL1 inhibitor with optimized in vivo clearance showing robust efficacy in preclinical solid and hematological tumor models (2023) (0)
Abstract 3371: A DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies (2023) (0)
Abstract 3624: Non-canonical proteins are cancer cell vulnerabilities in diverse malignancies (2022) (0)
Abstract 2682: Small molecule targeting the lipoic acid post-translational modification impacts proliferation of colorectal and PIK3CA-mutant cell lines (2022) (0)
Abstract B39: Genomic copy number alterations introduce a gene-independent viability bias in CRISPR-Cas9 knock-out screens of cancer cell lines (2017) (0)
A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies (2023) (0)
Abstract 214: Genetic and transcriptional instability alters cell line drug response (2018) (0)
Abstract PL07-01: Molecular profiling of breast cancer in Mexico: Identification of novel therapeutic targets through whole genome sequencing analysis. (2012) (0)
Abstract 806: RNA sequencing based prognostic indexes show a high degree of correlation with historic array based gene expression measurements in multiple myeloma. (2013) (0)
Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models (2016) (0)
Abstract LB-053:VPS4Ais a synthetic lethal target inVPS4B-deficient cancers due to co-deletion withSMAD4 (2020) (0)

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